Life Science / Cell biology  / stem cells

Asahikawa Medical College   Department of Medicine, Cardiology   Assistant Professor

2007.4 - 2008.5

Asahikawa Medical College   Pharmacology   Assistant Professor

2005.4 - 2007.3

University of Medicine and Dentistry of New Jersey   Cardiology   Assistant Professor

2000.2 - 2003.3

Pennsylvania State University   Medical School   Assistant Professor

2000.2 - 2000.7

Asahikawa Medical College   Department of Medicine Cardiologist

1997.4 - 2000.1

Harvard medical school   Brigham and Women's Hospital   instructor

1995.2 - 1997.3

Columbia University   College of physicians and surgeon, Pharmacology   senior research associate

1994.7 - 1995.1

Columbia University   College of physicians and surgeon   post doctoral fellow

1991.9 - 1994.6

Electrostatic interactions between single arginine and phospholipids modulate physiological properties of sarcoplasmic reticulum Ca2+-ATPase

Kazuo Yamasaki, Takashi Daiho, Satoshi Yasuda, Stefania Danko, Jun-ichi Kawabe, Hiroshi Suzuki

Scientific Reports   12 ( 1 )   2022.7

VEGF-Independent Angiogenic Factors: Beyond VEGF/VEGFR2 Signaling Reviewed International journal

Ryoji Eguchi, Jun-ichi Kawabe, Ichiro Wakabayashi

Journal of Vascular Research   59 ( 2 )   1 - 12   2022.2

Image-Based Crosstalk Analysis of Cell-Cell Interactions during Sprouting Angiogenesis using Blood-Vessel-on-a-Chip Reviewed International journal

Takanori Sano, Tadaaki Nakajima, Koharu Alicia Senda, Shizuka Nakano, Mizuho Yamato, Yukinori Ikeda, Hedele Zeng, Jun-ichi Kawabe, Yukiko T. Matsunaga

Stem Cell Research & Therapy   13 ( 1 )   2022

Sarcopenia-derived exosomal micro-RNA 16-5p disturbs cardio-repair via a pro-apoptotic mechanism in myocardial infarction in mice. International journal

Taiki Hayasaka, Naofumi Takehara, Tatsuya Aonuma, Kohei Kano, Kiwamu Horiuchi, Naoki Nakagawa, Hiroki Tanaka, Jun-Ichi Kawabe, Naoyuki Hasebe

Scientific reports   11 ( 1 )   19163 - 19163   2021.9

周細胞特異的Ninjurin 1欠損は、障害血管外膜vasa vasorumの形成異常に伴う炎症を介し血管内膜肥厚の増悪をもたらす

堀内 至, 鹿野 耕平, 蓑島 暁帆, 早坂 太希, 山内 敦司, 竜川 貴光, 松尾 梨沙, 吉田 有里, 富田 唯, 鹿原 真樹, 中川 直樹, 竹原 有史, 長谷部 直幸, 川辺 淳一

血管   44 ( 1 )   42 - 42   2021.6

Pericyte-specific deletion of ninjurin-1 induces fragile vasa vasorum formation and enhances intimal hyperplasia of injured vasculature. Reviewed

Horiuchi, K. Kano, K. Minoshima, A. Hayasaka, T. Yamauchi, A. Tatsukawa, T. Matsuo, R. Yoshida, Y. Tomita, Y. Kabara, M. Nakagawa, N. Takehara, N. Hasebe, N. Kawabe, J. I.

Am J Physiol Heart Circ Physiol.   320 ( 6 )   H2438 - H2447   2021.5

Pericyte-specific deletion of Ninjurin-1 induces fragile vasa vasorum formation and enhances intimal hyperplasia of injured vasculature. International journal

Kiwamu Horiuchi, Kohei Kano, Akiho Minoshima, Taiki Hayasaka, Atsushi Yamauchi, Takamitsu Tatsukawa, Risa Matsuo, Yuri Yoshida, Yui Tomita, Maki Kabara, Naoki Nakagawa, Naofumi Takehara, Naoyuki Hasebe, Jun-Ichi Kawabe

American journal of physiology. Heart and circulatory physiology   2021.5

EphA7(+) perivascular cells as myogenic and angiogenic precursors improving skeletal muscle regeneration in a muscular dystrophic mouse model Reviewed

Kano, K. Horiuchi, K. Yoshida, Y. Hayasaka, T. Kabara, M. Tomita, Y. Tatsukawa, T. Matsuo, R. Sawada, J. Nakagawa, N. Takehara, N. Hasebe, N. Kawabe, J. I.

Stem Cell Res   47   10194   2020.8

EphA7+ perivascular cells as myogenic and angiogenic precursors improving skeletal muscle regeneration in a muscular dystrophic mouse model. International journal

Kohei Kano, Kiwamu Horiuchi, Yuri Yoshida, Taiki Hayasaka, Maki Kabara, Yui Tomita, Takamitsu Tatsukawa, Risa Matsuo, Jun Sawada, Naoki Nakagawa, Naofumi Takehara, Naoyuki Hasebe, Jun-Ichi Kawabe

Stem cell research   47   101914 - 101914   2020.7

Capillary-resident EphA7+ pericytes are multipotent cells with anti-ischemic effects through capillary formation. Reviewed International journal

Yuri Yoshida, Maki Kabara, Kohei Kano, Kiwamu Horiuchi, Taiki Hayasaka, Yui Tomita, Naofumi Takehara, Akiho Minoshima, Tatsuya Aonuma, Keisuke Maruyama, Naoki Nakagawa, Nobuyoshi Azuma, Naoyuki Hasebe, Jun-Ichi Kawabe

Stem cells translational medicine   9 ( 1 )   120 - 130   2020.1

Capillary-resident EphA7+ pericytes are multipotent cells with anti-ischemic effects through capillary formation

Yoshida, Y. and Kabara, M. and Kano, K. and Horiuchi, K. and Hayasaka, T. and Tomita, Y. and Takehara, N. and Minoshima, A. and Aonuma, T. and Maruyama, K. and Nakagawa, N. and Azuma, N. and Hasebe, N. and Kawabe, J.-I.

Stem Cells Translational Medicine   9 ( 1 )   120 - 130   2020

Ninjurin 1 mediates peripheral nerve regeneration through Schwann cell maturation of NG2-positive cells. Reviewed International journal

Yui Tomita, Kiwamu Horiuchi, Kohei Kano, Takamitsu Tatsukawa, Risa Matsuo, Taiki Hayasaka, Yuri Yoshida, Maki Kabara, Satoshi Yasuda, Keiichi Nakajima, Naoki Nakagawa, Naofumi Takehara, Atsutaka Okizaki, Naoyuki Hasebe, Jun-Ichi Kawabe

Biochemical and biophysical research communications   519 ( 3 )   462 - 468   2019.11

The antioxidant and DNA-repair enzyme apurinic/apyrimidinic endonuclease 1 limits the development of tubulointerstitial fibrosis partly by modulating the immune system. Reviewed International journal

Keisuke Maruyama, Naoki Nakagawa, Tatsuya Aonuma, Yukihiro Saito, Taiki Hayasaka, Kohei Kano, Kiwamu Horiuchi, Naofumi Takehara, Jun-Ichi Kawabe, Naoyuki Hasebe

Scientific reports   9 ( 1 )   7823 - 7823   2019.5

日常生活状態における骨格筋組織の再生・維持に毛細血管周細胞が重要である

鹿野 耕平, 内田 紗瑛子, 鈴木 勇太, 田中 洋子, 田丸 祐也, 中島 恵一, 堀内 至, 澤田 潤, 長谷部 直幸, 川辺 淳一

日本老年医学会雑誌   56 ( Suppl. )   87 - 87   2019.5

The antioxidant and DNA-repair enzyme apurinic/apyrimidinic endonuclease 1 limits the development of tubulointerstitial fibrosis partly by modulating the immune system

Maruyama, K. and Nakagawa, N. and Aonuma, T. and Saito, Y. and Hayasaka, T. and Kano, K. and Horiuchi, K. and Takehara, N. and Kawabe, J.-I. and Hasebe, N.

Scientific Reports   9 ( 1 )   7823   2019

Ninjurin 1 mediates peripheral nerve regeneration through Schwann cell maturation of NG2-positive cells

Tomita, Y. and Horiuchi, K. and Kano, K. and Tatsukawa, T. and Matsuo, R. and Hayasaka, T. and Yoshida, Y. and Kabara, M. and Yasuda, S. and Nakajima, K. and Nakagawa, N. and Takehara, N. and Okizaki, A. and Hasebe, N. and Kawabe, J.-I.

Biochemical and Biophysical Research Communications   519 ( 3 )   462 - 468   2019

Pericyte-Specific Ninjurin1 Deletion Attenuates Vessel Maturation and Blood Flow Recovery in Hind Limb Ischemia. International journal

Akiho Minoshima, Maki Kabara, Motoki Matsuki, Yuri Yoshida, Kohei Kano, Yui Tomita, Taiki Hayasaka, Kiwamu Horiuchi, Yukihiro Saito, Tatsuya Aonuma, Masato Nishimura, Keisuke Maruyama, Naoki Nakagawa, Jun Sawada, Naofumi Takehara, Naoyuki Hasebe, Jun-Ichi Kawabe

Arteriosclerosis, thrombosis, and vascular biology   38 ( 10 )   2358 - 2370   2018.10

毛細血管周細胞特異的Ninjurun1欠損は血管内皮障害モデルにおいて外膜vasa vasorum形成異常と内膜肥厚をもたらす

堀内 至, 蓑島 暁帆, 鹿原 真樹, 松木 孝樹, 早坂 太希, 鹿野 耕平, 丸山 啓介, 澤田 潤, 中川 直樹, 竹原 有史, 川辺 淳一, 長谷部 直幸

日本高血圧学会総会プログラム・抄録集   41回   SHRY - 02   2018.9

A 3D in vitro pericyte-supported microvessel model: Visualisation and quantitative characterisation of multistep angiogenesis

Lee, E. and Takahashi, H. and Pauty, J. and Kobayashi, M. and Kato, K. and Kabara, M. and Kawabe, J.-I. and Matsunaga, Y.T.

Journal of Materials Chemistry B   6 ( 7 )   1085 - 1094   2018

Pericyte-specific ninjurin1 deletion attenuates vessel maturation and blood flow recovery in hind limb ischemia

Minoshima, A. and Kabara, M. and Matsuki, M. and Yoshida, Y. and Kano, K. and Tomita, Y. and Hayasaka, T. and Horiuchi, K. and Saito, Y. and Aonuma, T. and Nishimura, M. and Maruyama, K. and Nakagawa, N. and Sawada, J. and Takehara, N. and Hasebe, N. and Kawabe, J.-I.

Arteriosclerosis, Thrombosis, and Vascular Biology   38 ( 10 )   2358 - 2370   2018

A 3D in vitro pericyte-supported microvessel model: visualisation and quantitative characterisation of multistep angiogenesis

Eujin Lee, Haruko Takahashi, Joris Pauty, Masayoshi Kobayashi, Keisuke Kato, Maki Kabara, Jun-ichi Kawabe, Yukiko T. Matsunaga

Journal of Materials Chemistry B   6 ( 7 )   1085 - 1094   2018

Apoptosis-Resistant Cardiac Progenitor Cells Modified With Apurinic/Apyrimidinic Endonuclease/Redox Factor 1 Gene Overexpression Regulate Cardiac Repair After Myocardial Infarction Reviewed

Tatsuya Aonuma, Naofumi Takehara, Keisuke Maruyama, Maki Kabara, Motoki Matsuki, Atsushi Yamauchi, Jun-ichi Kawabe, Naoyuki Hasebe

STEM CELLS TRANSLATIONAL MEDICINE   5 ( 8 )   1067 - 1078   2016.8

Apoptosis-resistant cardiac progenitor cells modified with apurinic/apyrimidinic endonuclease/ redox factor 1 gene overexpression regulate cardiac repair after myocardial infarction

Aonuma, T. and Takehara, N. and Maruyama, K. and Kabara, M. and Matsuki, M. and Yamauchi, A. and Kawabe, J.-I. and Hasebe, N.

Stem Cells Translational Medicine   5 ( 8 )   1067 - 1078   2016

Ninjurin1 Is a Novel Factor to Regulate Angiogenesis Through the Function of Pericytes Reviewed

Motoki Matsuki, Maki Kabara, Yukihiro Saito, Kohei Shimamura, Akiho Minoshima, Masato Nishimura, Tatsuya Aonuma, Naofumi Takehara, Naoyuki Hasebe, Jun-ichi Kawabe

CIRCULATION JOURNAL   79 ( 6 )   1363 - +   2015.6

Association between Microalbuminuria Predicting In-Stent Restenosis after Myocardial Infarction and Cellular Senescence of Endothelial Progenitor Cells Reviewed

Hisanobu Ota, Naofumi Takehara, Tatsuya Aonuma, Maki Kabara, Motoki Matsuki, Atsushi Yamauchi, Toshiharu Takeuchi, Jun-ichi Kawabe, Naoyuki Hasebe

PLOS ONE   10 ( 4 )   e0123733   2015.4

Prostaglandin 12 analog suppresses lung metastasis by recruiting pericytes in tumor angiogenesis Reviewed

Yoshinori Minami, Takaaki Sasaki, Hiroki Bochimoto, Jun-ichi Kawabe, Satoshi Endo, Yoshiki Hira, Tsuyoshi Watanabe, Shunsuke Okumura, Naoyuki Hasebe, Yoshinobu Ohsaki

INTERNATIONAL JOURNAL OF ONCOLOGY   46 ( 2 )   548 - 554   2015.2

Prostaglandin I2 analog suppresses lung metastasis by recruiting pericytes in tumor angiogenesis

Minami, Y. and Sasaki, T. and Bochimoto, H. and Kawabe, J.-I. and Endo, S. and Hira, Y. and Watanabe, T. and Okumura, S. and Hasebe, N. and Ohsaki, Y.

International Journal of Oncology   46 ( 2 )   548 - 554   2015

Association between microalbuminuria predicting in-stent restenosis after myocardial infarction and cellular senescence of endothelial progenitor cells

Ota, H. and Takehara, N. and Aonuma, T. and Kabara, M. and Matsuki, M. and Yamauchi, A. and Takeuchi, T. and Kawabe, J.-I. and Hasebe, N.

PLoS ONE   10 ( 4 )   e0123733   2015

Ninjurin1 is a novel factor to regulate angiogenesis through the function of pericytes

Matsuki, M. and Kabara, M. and Saito, Y. and Shimamura, K. and Minoshima, A. and Nishimura, M. and Aonuma, T. and Takehara, N. and Hasebe, N. and Kawabe, J.-I.

Circulation Journal   79 ( 6 )   1363 - 1371   2015

Immortalized multipotent pericytes derived from the vasa vasorum in the injured vasculature. A cellular tool for studies of vascular remodeling and regeneration Reviewed

Maki Kabara, Jun-ichi Kawabe, Motoki Matsuki, Yoshiki Hira, Akiho Minoshima, Kohei Shimamura, Atsushi Yamauchi, Tatsuya Aonuma, Masato Nishimura, Yukihiro Saito, Naofumi Takehara, Naoyuki Hasebe

LABORATORY INVESTIGATION   94 ( 12 )   1340 - 1354   2014.12

Three cases of corticosteroid therapy triggering ventricular fibrillation in J-wave syndromes Reviewed

Naka Sakamoto, Nobuyuki Sato, Masahide Goto, Motoi Kobayashi, Naofumi Takehara, Toshiharu Takeuchi, Ahmed Karim Talib, Eitaro Sugiyama, Akiho Minoshima, Yasuko Tanabe, Kazumi Akasaka, Junichi Kawabe, Yuichiro Kawamura, Atsushi Doi, Naoyuki Hasebe

HEART AND VESSELS   29 ( 6 )   867 - 872   2014.11

Impaired Glutathione Redox System Paradoxically Suppresses Angiotensin II-Induced Vascular Remodeling Reviewed

Kazuma Izawa, Motoi Okada, Kazuhiro Sumitomo, Naoki Nakagawa, Yoshiaki Aizawa, Junichi Kawabe, Kenjiro Kikuchi, Naoyuki Hasebe

PLOS ONE   9 ( 10 )   e108115   2014.10

Nerve growth factor stimulates regeneration of perivascular nerve, and induces the maturation of microvessels around the injured artery Reviewed

Akira Asanome, Jun-ichi Kawabe, Motoki Matsuki, Maki Kabara, Yoshiki Hira, Hiroki Bochimoto, Atsushi Yamauchi, Tatsuya Aonuma, Naofumi Takehara, Tsuyoshi Watanabe, Naoyuki Hasebe

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   443 ( 1 )   150 - 155   2014.1

Immortalized multipotent pericytes derived from the vasa vasorum in the injured vasculature. A cellular tool for studies of vascular remodeling and regeneration

Kabara, M. and Kawabe, J.-I. and Matsuki, M. and Hira, Y. and Minoshima, A. and Shimamura, K. and Yamauchi, A. and Aonuma, T. and Nishimura, M. and Saito, Y. and Takehara, N. and Hasebe, N.

Laboratory Investigation   94 ( 12 )   1340 - 1354   2014

Initial reduction of oxidative stress by angiotensin receptor blocker contributes long term outcomes after percutaneous coronary intervention

Noro, T. and Takehara, N. and Sumitomo, K. and Takeuchi, T. and Ishii, Y. and Kato, J.-I. and Kawabe, J.-I. and Hasebe, N.

American Journal of Cardiovascular Disease   4 ( 4 )   159 - 167   2014

Role of the vasa vasorum and vascular resident stem cells in atherosclerosis

Kawabe, J.-I. and Hasebe, N.

BioMed Research International   2014   701571   2014

Nerve growth factor stimulates regeneration of perivascular nerve, and induces the maturation of microvessels around the injured artery

Asanome, A. and Kawabe, J.-I. and Matsuki, M. and Kabara, M. and Hira, Y. and Bochimoto, H. and Yamauchi, A. and Aonuma, T. and Takehara, N. and Watanabe, T. and Hasebe, N.

Biochemical and Biophysical Research Communications   443 ( 1 )   150 - 155   2014

Impaired glutathione redox system paradoxically suppresses angiotensin II-induced vascular remodeling

Izawa, K. and Okada, M. and Sumitomo, K. and Nakagawa, N. and Aizawa, Y. and Kawabe, J. and Kikuchi, K. and Hasebe, N.

PLoS ONE   9 ( 10 )   e108115   2014

Role of the Vasa Vasorum and Vascular Resident Stem Cells in Atherosclerosis Reviewed

Jun-ichi Kawabe, Naoyuki Hasebe

BIOMED RESEARCH INTERNATIONAL   2014   701571   2014

Initial reduction of oxidative stress by angiotensin receptor blocker contributes long term outcomes after percutaneous coronary intervention. Reviewed

Noro T, Takehara N, Sumitomo K, Takeuchi T, Ishii Y, Kato J, Kawabe J, Hasebe N

American journal of cardiovascular disease   4 ( 4 )   159 - 167   2014

Apurinic/apyrimidinic endonucelase 1 maintains adhesion of endothelial progenitor cells and reduces neointima formation Reviewed

Atsushi Yamauchi, Jun-ichi Kawabe, Maki Kabara, Motoki Matsuki, Akira Asanome, Tatsuya Aonuma, Hisanobu Ohta, Naofumi Takehara, Taku Kitagawa, Naoyuki Hasebe

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   305 ( 8 )   H1158 - H1167   2013.10

Prostacyclin Stimulated Integrin-Dependent Angiogenic Effects of Endothelial Progenitor Cells and Mediated Potent Circulation Recovery in Ischemic Hind Limb Model Reviewed

Yoko Aburakawa, Jun-ichi Kawabe, Motoi Okada, Atsushi Yamauchi, Akira Asanome, Maki Kabara, Motoki Matsuki, Naofumi Takehara, Naoki Nakagawa, Shunsuke Okumura, Yoshinori Minami, Yusuke Mizukami, Koh-ichi Yuhki, Fumitaka Ushikubi, Naoyuki Hasebe

CIRCULATION JOURNAL   77 ( 4 )   1053 - 1062   2013.4

Apurinic/apyrimidinic endonucelase 1 maintains adhesion of endothelial progenitor cells and reduces neointima formation

Yamauchi, A. and Kawabe, J.-I. and Kabara, M. and Matsuki, M. and Asanome, A. and Aonuma, T. and Ohta, H. and Takehara, N. and Kitagawa, T. and Hasebe, N.

American Journal of Physiology - Heart and Circulatory Physiology   305 ( 8 )   H1158 - H1167   2013

Three cases of corticosteroid therapy triggering ventricular fibrillation in J-wave syndromes

Sakamoto, N. and Sato, N. and Goto, M. and Kobayashi, M. and Takehara, N. and Takeuchi, T. and Talib, A.K. and Sugiyama, E. and Minoshima, A. and Tanabe, Y. and Akasaka, K. and Kawabe, J. and Kawamura, Y. and Doi, A. and Hasebe, N.

Heart and Vessels   29 ( 6 )   867 - 872   2013

Prostacyclin stimulated integrin-dependent angiogenic effects of endothelial progenitor cells and mediated potent circulation recovery in ischemic Hind limb model

Aburakawa, Y. and Kawabe, J.-I. and Okada, M. and Yamauchi, A. and Asanome, A. and Kabara, M. and Matsuki, M. and Takehara, N. and Nakagawa, N. and Okumura, S. and Minami, Y. and Mizukami, Y. and Yuhki, K.-I. and Ushikubi, F. and Hasebe, N.

Circulation Journal   77 ( 4 )   1053 - 1062   2013

The intrinsic prostaglandin E-2-EP4 system of the renal tubular epithelium limits the development of tubulointerstitial fibrosis in mice Reviewed

Naoki Nakagawa, Koh-ichi Yuhki, Jun-ichi Kawabe, Takayuki Fujino, Osamu Takahata, Maki Kabara, Kazutoshi Abe, Fumiaki Kojima, Hitoshi Kashiwagi, Naoyuki Hasebe, Kenjiro Kikuchi, Yukihiko Sugimoto, Shuh Narumiya, Fumitaka Ushikubi

KIDNEY INTERNATIONAL   82 ( 2 )   158 - 171   2012.7

The intrinsic prostaglandin E2-EP4 system of the renal tubular epithelium limits the development of tubulointerstitial fibrosis in mice Reviewed

Nakagawa N, Yuhki K, Kawabe J, Fujino T, Takahata O, Kabara M, Abe K, Kojima F, Kashiwagi H, Hasebe N, Kikuchi K, Sugimoto Y, Narumiya S, Ushikubi F.

Kidney Int   82 ( (2) )   158 - 171   2012.4

腎間質線維化におけるプロスタグランジンE2-EP4系の役割

中川 直樹, 結城 幸一, 小島 史章, 柏木 仁, 藤野 貴行, 川辺 淳一, 長谷部 直幸, 牛首 文隆

日本薬理学雑誌   139 ( 1 )   8P - 8P   2012.1

The intrinsic prostaglandin E<inf>2</inf>-EP<inf>4</inf> system of the renal tubular epithelium limits the development of tubulointerstitial fibrosis in mice

Nakagawa, N. and Yuhki, K.-I. and Kawabe, J.-I. and Fujino, T. and Takahata, O. and Kabara, M. and Abe, K. and Kojima, F. and Kashiwagi, H. and Hasebe, N. and Kikuchi, K. and Sugimoto, Y. and Narumiya, S. and Ushikubi, F.

Kidney International   82 ( 2 )   158 - 171   2012

Clinical and Genetic Investigation of a Japanese Family With Cardiac Fabry Disease Identification of a Novel alpha-Galactosidase A Missense Mutation (G195V) Reviewed

Naoki Nakagawa, Hiroki Maruyama, Takayuki Ishihara, Utako Seino, Jun-ichi Kawabe, Fumihiko Takahashi, Motoi Kobayashi, Atsushi Yamauchi, Yukie Sasaki, Naka Sakamoto, Hisanobu Ota, Yasuko Tanabe, Toshiharu Takeuchi, Toshihiro Takenaka, Kenjiro Kikuchi, Naoyuki Hasebe

INTERNATIONAL HEART JOURNAL   52 ( 5 )   308 - 311   2011.9

慢性腎臓病における血管内皮前駆細胞機能の検討

中川 直樹, 鹿原 真樹, 珍田 純子, 藤野 貴行, 竹原 有史, 川辺 淳一, 長谷部 直幸

日本腎臓学会誌   53 ( 3 )   414 - 414   2011.5

A case of idiopathic systemic capillary leak syndrome with high serum levels of G-CSF on exacerbation. Reviewed

Nakagawa N, Ota H, Tanabe Y, Kabara M, Matsuki M, Chinda J, Sakamoto N, Fujino T, Takehara N, Takeuchi T, Kawabe J, Sato N, Kawamura Y, Fukuhara T, Ikuta K, Kikuchi K, Hasebe N.

Intern Med   50 ( 6 )   597 - 600   2011.4

Clinical and genetic investigation of a Japanese family with cardiac fabry disease. Identification of a novel α-galactosidase A missense mutation (G195V). Reviewed

Nakagawa N, Maruyama H, Ishihara T, Seino U, Kawabe J, Takahashi F, Kobayashi M, Yamauchi A, Sasaki Y, Sakamoto N, Ota H, Tanabe Y, Takeuchi T, Takenaka T, Kikuchi K, Hasebe N.

Int Heart J   52 ( 5 )   308 - 311   2011.4

Roles of prostanoids in the pathogenesis of cardiovascular diseases: Novel insights from knockout mouse studies. Invited Reviewed

Yuhki K., Kojima F., Kashiwagi H., Kawabe J., Fujino T., Narumiya S., Ushikubi F.

Pharmacology and Therapeutics   129 ( 2 )   195 - 205   2011.2

Roles of prostanoids in the pathogenesis of cardiovascular from knockout mouse studies Reviewed

Koh-ichi Yuhki, Fumiaki Kojima, Hitoshi Kashiwagi, Jun-ichi Kawabe, Takayuki Fujino, Shuh Narumiya, Fumitaka Ushikubi

PHARMACOLOGY & THERAPEUTICS   129 ( 2 )   195 - 205   2011.2

Clinical and genetic investigation of a Japanese family with cardiac fabry disease: Identification of a novel α-galactosidase a missense mutation (G195V)

Nakagawa, N. and Maruyama, H. and Ishihara, T. and Seino, U. and Kawabe, J. and Takahashi, F. and Kobayashi, M. and Yamauchi, A. and Sasaki, Y. and Sakamoto, N. and Ota, H. and Tanabe, Y. and Takeuchi, T. and Takenaka, T. and Kikuchi, K. and Hasebe, N.

International Heart Journal   52 ( 5 )   308 - 311   2011

A Case of Idiopathic Systemic Capillary Leak Syndrome with High Serum Levels of G-CSF on Exacerbation

Nakagawa, N. and Ota, H. and Tanabe, Y. and Kabara, M. and Matsuki, M. and Chinda, J. and Sakamoto, N. and Fujino, T. and Takehara, N. and Takeuchi, T. and Kawabe, J.-I. and Sato, N. and Kawamura, Y. and Fukuhara, T. and Ikuta, K. and Kikuchi, K. and Hasebe, N.

Internal Medicine   50 ( 6 )   597 - 600   2011

Roles of prostanoids in the pathogenesis of cardiovascular diseases: Novel insights from knockout mouse studies

Yuhki, K.-I. and Kojima, F. and Kashiwagi, H. and Kawabe, J.-I. and Fujino, T. and Narumiya, S. and Ushikubi, F.

Pharmacology and Therapeutics   129 ( 2 )   195 - 205   2011

A Case of Idiopathic Systemic Capillary Leak Syndrome with High Serum Levels of G-CSF on Exacerbation Reviewed

Naoki Nakagawa, Hisanobu Ota, Yasuko Tanabe, Maki Kabara, Motoki Matsuki, Junko Chinda, Naka Sakamoto, Takayuki Fujino, Naofumi Takehara, Toshiharu Takeuchi, Jun-ichi Kawabe, Nobuyuki Sato, Yuichiro Kawamura, Takashi Fukuhara, Katsuya Ikuta, Kenjiro Kikuchi, Naoyuki Hasebe

INTERNAL MEDICINE   50 ( 6 )   597 - 600   2011

Apurinic/apyrimidinic Endonuclease(APE1)遺伝子導入した内皮前駆細胞(EPC)による新生内膜肥厚改善効果 高機能EPCの開発を目指して

山内 敦司, 川辺 淳一, 浅野目 晃, 小林 基, 松木 孝樹, 竹原 有史, 中川 直樹, 西浦 猛, 太田 久宣, 岡田 基, 竹内 利治, 長谷部 直幸

脈管学   50 ( Suppl. )   S228 - S228   2010.9

内皮前駆細胞(EPC)を介したプロスタサイクリンの下肢虚血改善作用 血管周細胞分化による血管新生効果

浅野目 晃, 川辺 淳一, 岡田 基, 山内 敦司, 小林 基, 松木 孝樹, 竹原 有史, 中川 直樹, 西浦 猛, 太田 久宣, 竹内 利治, 長谷部 直幸

脈管学   50 ( Suppl. )   S333 - S333   2010.9

Transplanting Normal Vascular Proangiogenic Cells to Tumor-Bearing Mice Triggers Vascular Remodeling and Reduces Hypoxia in Tumors Reviewed

Junpei Sasajima, Yusuke Mizukami, Yoshiaki Sugiyama, Kazumasa Nakamura, Toru Kawamoto, Kazuya Koizumi, Rie Fujii, Wataru Motomura, Kazuya Sato, Yasuaki Suzuki, Satoshi Tanno, Mikihiro Fujiya, Katsunori Sasaki, Norihiko Shimizu, Hidenori Karasaki, Toru Kono, Jun-ichi Kawabe, Masaaki Ii, Hiroki Yoshiara, Naohisa Kamiyama, Toshifumi Ashida, Nabeel Bardeesy, Daniel C. Chung, Yutaka Kohgo

CANCER RESEARCH   70 ( 15 )   6283 - 6292   2010.8

Prostacyclin in Vascular Diseases - Recent Insights and Future Perspectives Reviewed

Jun-ichi Kawabe, Fumitaka Ushikubi, Naoyuki Hasebe

CIRCULATION JOURNAL   74 ( 5 )   836 - 843   2010.5

Hedgehog promotes neovascularization in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells. Reviewed

Nakamura N, Sasaki J, Mizukami Y, Sugiyama Y, Yamazaki M, Fujii R, Kawamoto T, Koizumi K, Sato K, Fujiya M, Sasaki K, Tanno S, Okumura T, Shimizu N, Kawabe J, Karasaki H, Kono T, Ii M, Bardeesy N, Chung D C, Kohgo Y.

ProsOne   5 ( (1) )   e8824 - e8835   2010.4

Prostaglandin I2 promotes recruitment of endothelial progenitor cells and limits vascular remodeling. Reviewed

Kawabe J, Yuhki KI, Okada M, Kanno T, Yamauchi A, Tashiro N, Sasaki T, Okumura S, Nakagawa N, Aburakawa Y, Takehara N, Fujino T, Hasebe N, Narumiya S, Ushikubi F

Atheroscler. Thromb Vasc Biol   30 ( (3) )   464 - 470   2010.4

Prostaglandin I-2 Promotes Recruitment of Endothelial Progenitor Cells and Limits Vascular Remodeling Reviewed

Jun-ichi Kawabe, Koh-ichi Yuhki, Motoi Okada, Takayasu Kanno, Atsushi Yamauchi, Naohiko Tashiro, Takaaki Sasaki, Shunsuke Okumura, Naoki Nakagawa, Youko Aburakawa, Naofumi Takehara, Takayuki Fujino, Naoyuki Hasebe, Shuh Narumiya, Fumitaka Ushikubi

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY   30 ( 3 )   464 - U213   2010.3

Prostaglandin I2 promotes recruitment of endothelial progenitor cells and limits vascular remodeling. Reviewed

Kawabe J., Yuhki K., Okada M., Kanno T., Yamauchi A., Tashiro N., Sasaki T., Okumura S., Nakagawa N., Aburakawa Y., Takehara N., Fujino T., Hasebe N., Narumiya S., Ushikubi F.

Arteriosclerosis, Thrombosis and Vascular Biology   30 ( 3 )   464 - 470   2010.2

Hedgehog Promotes Neovascularization in Pancreatic Cancers by Regulating Ang-1 and IGF-1 Expression in Bone-Marrow Derived Pro-Angiogenic Cells Reviewed

Kazumasa Nakamura, Junpei Sasajima, Yusuke Mizukami, Yoshiaki Sugiyama, Madoka Yamazaki, Rie Fujii, Toru Kawamoto, Kazuya Koizumi, Kazuya Sato, Mikihiro Fujiya, Katsunori Sasaki, Satoshi Tanno, Toshikatsu Okumura, Norihiko Shimizu, Jun-ichi Kawabe, Hidenori Karasaki, Toru Kono, Masaaki Ii, Nabeel Bardeesy, Daniel C. Chung, Yutaka Kohgo

PLOS ONE   5 ( 1 )   e8824   2010.1

Transplanting normal vascular proangiogenic cells to tumor-bearing mice triggers vascular remodeling and reduces hypoxia in tumors

Sasajima, J. and Mizukami, Y. and Sugiyama, Y. and Nakamura, K. and Kawamoto, T. and Koizumi, K. and Fujii, R. and Motomura, W. and Sato, K. and Suzuki, Y. and Tanno, S. and Fujiya, M. and Sasaki, K. and Shimizu, N. and Karasaki, H. and Kono, T. and Kawabe, J.-I. and Ii, M. and Yoshiara, H. and Kamiyama, N. and Ashida, T. and Bardeesy, N. and Chung, D.C. and Kohgo, Y.

Cancer Research   70 ( 15 )   6283 - 6292   2010

Hedgehog promotes neovascularization in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells

Nakamura, K. and Sasajima, J. and Mizukami, Y. and Sugiyama, Y. and Yamazaki, M. and Fujii, R. and Kawamoto, T. and Koizumi, K. and Sato, K. and Fujiya, M. and Sasaki, K. and Tanno, S. and Okumura, T. and Shimizu, N. and Kawabe, J.-I. and Karasaki, H. and Kono, T. and Ii, M. and Bardeesy, N. and Chung, D.C. and Kohgo, Y.

PLoS ONE   5 ( 1 )   e8824   2010

Prostaglandin I2 promotes recruitment of endothelial progenitor cells and limits vascular remodeling

Kawabe, J.-I. and Yuhki, K.-I. and Okada, M. and Kanno, T. and Yamauchi, A. and Tashiro, N. and Sasaki, T. and Okumura, S. and Nakagawa, N. and Aburakawa, Y. and Takehara, N. and Fujino, T. and Hasebe, N. and Narumiya, S. and Ushikubi, F.

Arteriosclerosis, Thrombosis, and Vascular Biology   30 ( 3 )   464 - 470   2010

Roles of prostanoids in the pathogenesis of cardiovascular diseases

Yuhki, K. and Kashiwagi, H. and Kojima, F. and Kawabe, J. and Ushikubi, F.

International Angiology   29 ( 2 SUPPL. 1 )   19 - 27   2010

Prostacyclin in vascular diseases - Recent insights and future perspectives

Kawabe, J. and Ushikubi, F. and Hasebe, N.

Circulation Journal   74 ( 5 )   836 - 843   2010

新規遺伝子変異を認めたFabry病の1家系

中川 直樹, 高橋 文彦, 藤野 貴行, 川辺 淳一, 菊池 健次郎, 石原 貴起, 丸山 弘樹, 長谷部 直幸

日本腎臓学会誌   51 ( 3 )   343 - 343   2009.4

Brugada syndrome case: Difficult differentiation between a concealed form and tricyclic antidepressant-induced Brugada sign

Tashiro, N. and Sato, N. and Talib, A.K. and Talib, A.K. and Saito, E. and Okura, M. and Yamaki, M. and Nakagawa, N. and Sakamoto, N. and Ota, H. and Tanabe, Y. and Takeuchi, T. and Akasaka, K. and Kawabe, J. and Kawamura, Y. and Hasebe, N.

Internal Medicine   48 ( 17 )   1535 - 1539   2009

Brugada Syndrome Case: Difficult Differentiation Between a Concealed Form and Tricyclic Antidepressant-induced Brugada Sign Reviewed

Naohiko Tashiro, Nobuyuki Sato, Ahmed Karim Talib, Ali Karim Talib, Erika Saito, Minako Okura, Masaru Yamaki, Naoki Nakagawa, Naka Sakamoto, Hisanobu Ota, Yasuko Tanabe, Toshiharu Takeuchi, Kazumi Akasaka, Junichi Kawabe, Yuichiro Kawamura, Naoyuki Hasebe

INTERNAL MEDICINE   48 ( 17 )   1535 - 1539   2009

自然発症高血圧ラットの血管傷害モデルにおいて温浴は降圧以上の新生内膜抑制作用を有する

田代 直彦, 岡田 基, 川辺 淳一, 長谷部 直幸

日本高血圧学会総会プログラム・抄録集   31回   306 - 306   2008.10

Administration of VEGF receptor tyrosine kinase inhibitor increases VEGF production causing angiogenesis in human small-cell lung cancer xenografts Reviewed

Takaaki Sasaki, Sachie Tanno, Kiyoko Shibukawa, Shinobu Osanai, Junichi Kawabe, Yoshinobu Ohsaki

INTERNATIONAL JOURNAL OF ONCOLOGY   33 ( 3 )   525 - 532   2008.9

Administration of VEGF receptor tyrosine kinase inhibitor increases VEGF production causing angiogenesis in human small-cell lung cancer xenografts. Reviewed

Sasaki T, Tanno S, Shibukawa K, Osanai S, Kawabe J, Ohsaki Y,

Int J Oncol.   33 ( (3) )   525 - 532   2008.4

Administration of VEGF receptor tyrosine kinase inhibitor increases VEGF production causing angiogenesis in human small-cell lung cancer xenografts

Sasaki, T. and Tanno, S. and Shibukawa, K. and Osanai, S. and Kawabe, J. and Ohsaki, Y.

International Journal of Oncology   33 ( 3 )   525 - 532   2008

Disruption of type 5 adenylyl cyclase enhances desensitization of cyclic adenosine monophosphate signal and increases Akt signal with chronic catecholamine stress Reviewed

Satoshi Okumura, Dorothy E. Vatner, Reiko Kurotani, Yunzhe Bai, Shumin Gao, Zengrong Yuan, Kousaku Iwatsubo, Coskun Ulucan, Jun-ichi Kawabe, Kaushik Ghosh, Stephen F. Vatner, Yoshihlro Ishikawa

CIRCULATION   116 ( 16 )   1776 - 1783   2007.10

Disruption of type 5 adenylyl cyclase enhances desensitization of cyclic adenosine monophosphate signal and increases Akt signal with chronic catecholamine stress. Reviewed

Okumura S, Vatner DE, Kurotani R, Bai Y, Gao S, Yuan Z, Iwatsubo K, Ulucan C, Kawabe J, Ghosh K, Vatner SF, Ishikawa Y,

Circulation   116   1776 - 1783   2007.4

プロスタノイドの糖尿病性および腎摘出後腎症における役割 受容体欠損マウスを用いた検討

藤野 貴行, 阿部 和利, 中川 直樹, 長谷部 直幸, 結城 幸一, 川辺 淳一, 菊池 健次郎, 牛首 文隆

日本腎臓学会誌   49 ( 3 )   337 - 337   2007.4

Disruption of type 5 adenylyl cyclase enhances desensitization of cyclic adenosine monophosphate signal and increases Akt signal with chronic catecholamine stress

Okumura, S. and Vatner, D.E. and Kurotani, R. and Bai, Y. and Gao, S. and Yuan, Z. and Iwatsubo, K. and Ulucan, C. and Kawabe, J.-I. and Ghosh, K. and Vatner, S.F. and Ishikawa, Y.

Circulation   116 ( 16 )   1776 - 1783   2007

温浴の降圧効果と抗動脈硬化作用

田代 直彦, 長谷部 直幸, 岡田 基, 斉藤 江里香, 松木 孝樹, 三浦 恵理子, 山内 敦司, 菅野 貴康, 小倉 幸恵, 八巻 多, 住友 和弘, 太田 久宣, 坂本 央, 野呂 忠孝, 藤野 貴行, 田邊 康子, 竹原 有史, 竹内 利治, 福澤 純, 佐藤 伸之, 赤坂 和美, 川村 祐一郎, 川辺 淳一, 中木 良彦, 杉岡 良彦, 西條 泰明, 吉田 貴彦, 菊池 健次郎

Journal of Cardiology   48 ( Suppl.I )   483 - 483   2006.9

温浴療法による血管内皮機能の改善効果

小倉 幸恵, 長谷部 直幸, 竹原 有史, 赤坂 和美, 斉藤 江里香, 松木 孝樹, 三浦 恵理子, 田代 直彦, 山内 敦司, 菅野 貴康, 八巻 多, 住友 和弘, 太田 久宣, 坂本 央, 野呂 忠孝, 藤野 貴行, 田邊 康子, 竹内 利治, 岡田 基, 川辺 淳一, 福澤 純, 佐藤 伸之, 川村 祐一郎, 中木 良彦, 杉岡 良彦, 西條 泰明, 吉田 貴彦, 菊池 健次郎

Journal of Cardiology   48 ( Suppl.I )   584 - 584   2006.9

Caveolin regulates microtubule polymerization in the vascular smooth muscle cells. Reviewed

Kawabe J, Okumura S, Nathanson MA, Hasebe N, Ishikawa Y

Biochem Biophys Res Com   342   164 - 169   2006.4

Caveolin regulates microtubule polymerization in the vascular smooth muscle cells Reviewed

J Kawabe, S Okumura, MA Nathanson, N Hasebe, Y Ishikawa

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   342 ( 1 )   164 - 169   2006.3

血管病の分子メカニズムと新しい治療戦略 心血管系におけるプロスタノイドの役割(Molecular mechanism and novel therapeutic strategies of vascular diseases: Roles of the prostanoids in the cardiovascular system) Reviewed

Yuhki Koh-ichi, Kawabe Jun-ichi, Takahata Osamu, Hara Akiyoshi, Narumiya Shuh, Ushikubi Fumitaka

Journal of Pharmacological Sciences   100 ( Suppl.I )   43P - 43P   2006.2

Role of prostanoids in inflammatory tachycardia: A reply to the letter of Dr. Eugene Nalivaiko [2]

Yuhki, K.-I. and Kawabe, J.-I. and Ushikubi, F.

American Journal of Physiology - Regulatory Integrative and Comparative Physiology   290 ( 6 )   2006

Caveolin regulates microtubule polymerization in the vascular smooth muscle cells

Kawabe, J.-I. and Okumura, S. and Nathanson, M.A. and Hasebe, N. and Ishikawa, Y.

Biochemical and Biophysical Research Communications   342 ( 1 )   164 - 169   2006

【プロスタグランジンの多様性】循環器系におけるプロスタノイドの役割

結城 幸一, 藤野 貴行, 川辺 淳一, 原 明義, 牛首 文隆

炎症と免疫   14 ( 1 )   59 - 65   2005.12

Fat, keeping the heart healthy? Reviewed

K Yuhki, J Kawabe, F Ushikubi

NATURE MEDICINE   11 ( 10 )   1048 - 1049   2005.10

ピタバスタチンは熱ショック蛋白を発現誘導しアンジオテンシンIIによる細胞の酸化ストレスを抑制する

岡田 基, 田代 直彦, 井澤 和眞, 川辺 淳一, 長谷部 直幸, 菊池 健次郎

日本高血圧学会総会プログラム・抄録集   28回   126 - 126   2005.9

温浴による血圧上昇の抑制効果と抗動脈硬化作用

田代 直彦, 岡田 基, 井澤 和眞, 会沢 佳昭, 川辺 淳一, 住友 和弘, 藤野 貴行, 福澤 純, 長谷部 直幸, 菊池 健次郎

日本高血圧学会総会プログラム・抄録集   28回   209 - 209   2005.9

Fat, keeping the heart healthy?　 Reviewed

Yuhki K, Kawabe J , Ushikubi H

Nat Med   1048 - 1049   2005.4

Fat, keeping the heart healthy?

Yuhki, K.-I. and Kawabe, J.-I. and Ushikubi, F.

Nature Medicine   11 ( 10 )   1048 - 1049   2005

Insulin resistance in skeletal muscles of caveolin-3-null mice Reviewed

J Oshikawa, K Otsu, Y Toya, T Tsunematsu, R Hankins, J Kawabe, S Minamisawa, S Umemura, Y Hagiwara, Y Ishikawa

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   101 ( 34 )   12670 - 12675   2004.8

温熱はピタバスタチンの抗酸化作用と熱ストレス蛋白の発現を増強して血管平滑筋細胞の活性化を抑制する

岡田 基, 井澤 和眞, 住友 和弘, 会澤 佳昭, 川辺 淳一, 長谷部 直幸, 横田 真一, 菊池 健次郎

日本動脈硬化学会総会プログラム・抄録集   36回   221 - 221   2004.7

血管リモデリングにおけるAngiotensin IIと酸化ストレスの影響

井澤 和眞, 岡田 基, 川辺 淳一, 中川 直樹, 菅野 厚博, 住友 和弘, 長谷部 直幸, 菊池 健次郎

日本動脈硬化学会総会プログラム・抄録集   36回   221 - 221   2004.7

温熱による熱ショック蛋白の発現誘導と新生内膜肥厚抑制のメカニズムの解明

岡田 基, 井澤 和眞, 住友 和弘, 会澤 佳昭, 川辺 淳一, 長谷部 直幸, 横田 真一, 菊池 健次郎

日本動脈硬化学会総会プログラム・抄録集   36回   221 - 221   2004.7

Translocation of caveolin regulates stretch-induced ERK activity in vascular smooth muscle Reviewed

J Kawabe, S Okumura, MC Lee, J Sadoshima, Y Ishikawa

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   286 ( 5 )   H1845 - H1852   2004.5

Translocation of caveolin regulates stretch-induced ERK activity in vascular smooth muscle cells. Reviewed

Kawabe J, Okumura S, Lee MC, Sadoshima J, and Ishikawa Y.

Am J Physiol Heart Circ Physiol   286 ( (5) )   H1845 - H1852   2004.4

A cardiac sodium channel mutation identified in Brugada syndrome associated with atrial standstill. Reviewed

Takehara N, Makita N, Kawabe J , Sato N, Kawamura Y, Kitabatake A, and Kikuchi K,

J Intern Med   255   137 - 142   2004.4

Insulin resistance in skeletal muscles of caveolin-3-null mice. Reviewed

Oshikawa J, Otsu K, Toya Y, Tsunematsu T, Hankins R, Kawabe J, Minamisawa S, Umemura S, Hagiwara Y, and Ishikawa Y.

Proc Natl Acad Sci U S A   101 ( (34) )   12670 - 12675   2004.4

Thermal treatment attenuates neointimal thickening with enhanced expression of heat-shock protein 72 and suppression of oxidative stress. Reviewed

Okada M, Hasebe N, Aizawa Y, Izawa K, Kawabe J, and Kikuchi K

Circulation   109 ( (14) )   1763 - 1768   2004.4

Thermal treatment attenuates neointimal thickening with enhanced expression of heat-shock protein 72 and suppression of oxidative stress Reviewed

M Okada, N Hasebe, Y Aizawa, K Izawa, J Kawabe, K Kikuchi

CIRCULATION   109 ( 14 )   1763 - 1768   2004.4

【分子高血圧 最新の進歩】温熱による新生内膜肥厚の抑制効果 熱ショック蛋白の発現と酸化ストレスの抑制の役割

岡田 基, 長谷部 直幸, 会澤 佳昭, 井澤 和眞, 川辺 淳一, 菊池 健次郎

血圧   11 ( 3 )   263 - 267   2004.3

Insulin resistance in skeletal muscles of caveolin-3-null mice

Oshikawa, J. and Otsu, K. and Toya, Y. and Tsunematsu, T. and Hankins, R. and Kawabe, J.-I. and Minamisawa, S. and Umemura, S. and Hagiwara, Y. and Ishikawa, Y.

Proceedings of the National Academy of Sciences of the United States of America   101 ( 34 )   12670 - 12675   2004

A cardiac sodium channel mutation identified in Brugada syndrome associated with atrial standstill

Takehara, N. and Makita, N. and Kawabe, J. and Sato, N. and Kawamura, Y. and Kitabatake, A. and Kikuchi, K.

Journal of Internal Medicine   255 ( 1 )   137 - 142   2004

Thermal Treatment Attenuates Neointimal Thickening with Enhanced Expression of Heat-Shock Protein 72 and Suppression of Oxidative Stress

Okada, M. and Hasebe, N. and Aizawa, Y. and Izawa, K. and Kawabe, J.-I. and Kikuchi, K.

Circulation   109 ( 14 )   1763 - 1768   2004

Translocation of caveolin regulates stretch-induced ERK activity in vascular smooth muscle cells

Kawabe, J.-I. and Okumura, S. and Lee, M.-C. and Sadoshima, J. and Ishikawa, Y.

American Journal of Physiology - Heart and Circulatory Physiology   286 ( 5 55-5 )   H1845 - H1852   2004

A cardiac sodium channel mutation identified in Brugada syndrome associated with atrial standstill.

Takehara N, Makita N, Kawabe J, Sato N, Kawamura Y, Kitabatake A, Kikuchi K

J Int Med   255 ( 1 )   137 - 142   2004

温熱療法は熱ショックタンパクの発現と酸化ストレスの抑制により傷害血管の新生内膜肥厚を抑制する

岡田 基, 会澤 佳昭, 井澤 和眞, 川辺 淳一, 長谷部 直幸, 菊池 健次郎

日本高血圧学会総会プログラム・抄録集   26回   189 - 189   2003.10

温熱治療はの酸化ストレスを減少させ新生内膜肥厚を抑制する

岡田 基, 会澤 佳昭, 井澤 和眞, 川辺 淳一, 長谷部 直幸, 菊池 健次郎

日本内分泌学会雑誌   79 ( 2 )   536 - 536   2003.9

Nicotinic acetylcholine receptor alpha(7) regulates cAMP signal within lipid rafts Reviewed

J Oshikawa, Y Toya, T Fujita, M Egawa, J Kawabe, S Umemura, Y Ishikawa

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY   285 ( 3 )   C567 - C574   2003.9

Type 5 adenylyl cyclase disruption alters not only sympathetic but also parasympathetic and calcium-mediated cardiac regulation. Reviewed

Okumura Satoshi, Kawabe Jun-ichi, Yatani Atsuko, Takagi Gen, Lee Ming-Chih, Hong Chull, Liu Jing, Takagi Ikuyo, Sadoshima Junichi, Vatner Dorothy E, Vatner, Stephen F, Ishikawa Yoshihiro

Circulation Research   93 ( 4 )   364 - 71   2003.8

Type 5 adenylyl cyclase disruption alters not only sympathetic but also parasympathetic and calcium-mediated cardiac regulation Reviewed

S Okumura, J Kawabe, A Yatani, G Takagi, MC Lee, C Hong, J Liu, Takagi, I, J Sadoshima, DE Vatner, SF Vatner, Y Ishikawa

CIRCULATION RESEARCH   93 ( 4 )   364 - 371   2003.8

Disruption of type 5 adenylyl cyclase gene preserves cardiac function against pressure overload Reviewed

S Okumura, G Takagi, J Kawabe, GP Yang, MC Lee, C Hong, J Liu, DE Vatner, J Sadoshima, SF Vatner, Y Ishikawa

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   100 ( 17 )   9986 - 9990   2003.8

Motor dysfunction in type 5 adenylyl cyclase-null mice Reviewed

T Iwamoto, S Okumura, K Iwatsubo, JI Kawabe, K Ohtsu, Sakai, I, Y Hashimoto, A Izumitani, K Sango, K Ajiki, Y Toya, S Umemura, Y Goshima, N Arai, SF Vatner, Y Ishikawa

JOURNAL OF BIOLOGICAL CHEMISTRY   278 ( 19 )   16936 - 16940   2003.5

Effect of beta-adrenoceptor antagonist and angiotensin-converting enzyme inhibitor on hypertension-associated changes in adenylyl cyclase type V messenger RNA expression in spontaneously hypertensive rats Reviewed

T Fujino, N Hasebe, J Kawabe, M Fujita, J Fukuzawa, K Tobise, K Kikuchi

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY   41 ( 5 )   720 - 725   2003.5

Effect of -adrenoceptor antagonist and ACE inhibitor on hypertension-associated changes in AC type V messenger RNA expression in SHR. Reviewed

Fujino T, Hasebe N, Kawabe J , Fujita M, Fukuzawa J, Tobise K, and Kikuchi K.

J Cardiovasc Pharmacol,   41   720 - 725   2003.4

Type 5 AC disruption alters not only sympathetic but also parasympathetic and Ca-mediated cardiac regulation Reviewed

Okumura S, Kawabe J et al)

Circ Res   93   364 - 371   2003.4

Nicotinic acetylcholine receptor alpha 7 regulates cAMP signal within lipid rafts Reviewed

Oshikawa J, Toya Y, Fujita T, Egawa M, Kawabe J , Umemura S, and Ishikawa Y

Am J Physiol Heart Circ Physiol   285   C567 - C574   2003.4

Disruption of type 5 adenylyl cyclase gene preserves cardiac function against pressure overload. Reviewed

Okumura S, Takagi G, Kawabe J , et al

Proc Natl Acad Sci U S A,   100   9986 - 9990   2003.4

Motor dysfunction in type 5 adenylyl cyclase-null mice.　 Reviewed

Iwamoto T, Okumura S, Iwatsubo K, Kawabe J , et al

J Biol Chem,   278   6936 - 6940   2003.4

Nicotinic acetylcholine receptor α<inf>7</inf> regulates cAMP signal within lipid rafts

Oshikawa, J. and Toya, Y. and Fujita, T. and Egawa, M. and Kawabe, J. and Umemura, S. and Ishikawa, Y.

American Journal of Physiology - Cell Physiology   285 ( 3 54-3 )   C567 - C574   2003

Effect of β-adrenoceptor antagonist and angiotensin-converting enzyme inhibitor on hypertension-associated changes in adenylyl cyclase type V messenger RNA expression in spontaneously hypertensive rats

Fujino, T. and Hasebe, N. and Kawabe, J.-I. and Fujita, M. and Fukuzawa, J. and Tobise, K. and Kikuchi, K.

Journal of Cardiovascular Pharmacology   41 ( 5 )   720 - 725   2003

Motor dysfunction in type 5 adenylyl cyclase-null mice

Iwamoto, T. and Okumura, S. and Iwatsubo, K. and Kawabe, J.-I. and Ohtsu, K. and Sakai, I. and Hashimoto, Y. and Izumitani, A. and Sango, K. and Ajiki, K. and Toya, Y. and Umemura, S. and Goshima, Y. and Arai, N. and Vatner, S.F. and Ishikawa, Y.

Journal of Biological Chemistry   278 ( 19 )   16936 - 16940   2003

Disruption of type 5 adenylyl cyclase gene preserves cardiac function against pressure overload

Okumura, S. and Takagi, G. and Kawabe, J.-I. and Yang, G. and Lee, M.-C. and Hong, C. and Liu, J. and Vatner, D.E. and Sadoshima, J. and Vatner, S.F. and Ishikawa, Y.

Proceedings of the National Academy of Sciences of the United States of America   100 ( 17 )   9986 - 9990   2003

Type 5 adenylyl cyclase disruption alters not only sympathetic but also parasympathetic and calcium-mediated cardiac regulation

Okumura, S. and Kawabe, J.-I. and Yatani, A. and Takagi, G. and Lee, M.-C. and Hong, C. and Liu, J. and Takagi, I. and Sadoshima, J. and Vatner, D.E. and Vatner, S.F. and Ishikawa, Y.

Circulation Research   93 ( 4 )   364 - 371   2003

Magnesium reduces myocardial infarct size via enhancement of adenosine mechanism in rabbits Reviewed

T Matsusaka, N Hasebe, YT Jin, J Kawabe, K Kikuchi

CARDIOVASCULAR RESEARCH   54 ( 3 )   568 - 575   2002.6

Mg reduces myocardial infarct size via enhancement of ade mechanism in rabbits. Reviewed

Matsusaka T, Hasebe N, Jin YT, Kawabe J , and Kikuchi K

Cardiovasc Res,   54   568 - 575   2002.4

Down-regulation of NO accumulation by COX-2 induction and TXA2 production in interleukin-1b-stimulated rat aortic smooth muscle cells. Reviewed

Shiokoshi T, Ohsaki Y, Kawabe J , Fujino T, and Kikuchi K.)

J Hypertens,   20   455 - 461   2002.4

Downregulation of nitric oxide accumulation by cyclooxygenase-2 induction and thromboxane A(2) production in interieukin-1 beta-stimulated rat aortic smooth muscle cells Reviewed

T Shiokoshi, Y Ohsaki, J Kawabe, T Fujino, K Kikuchi

JOURNAL OF HYPERTENSION   20 ( 3 )   455 - 461   2002.3

Magnesium reduces myocardial infarct size via enhancement of adenosine mechanism in rabbits

Matsusaka, T. and Hasebe, N. and Jin, Y.-T. and Kawabe, J. and Kikuchi, K.

Cardiovascular Research   54 ( 3 )   568 - 575   2002

Downregulation of nitric oxide accumulation by cyclooxygenase-2 induction and thromboxane A<inf>2</inf> production in interleukin-1β-stimulated rat aortic smooth muscle cells

Shiokoshi, T. and Ohsaki, Y. and Kawabe, J. and Fujino, T. and Kikuchi, K.

Journal of Hypertension   20 ( 3 )   455 - 461   2002

Pioglitazone enhances cytokine-induced apoptosis in vascular smooth muscle cells and reduces intimal hyperplasia Reviewed

Y Aizawa, J Kawabe, N Hasebe, N Takehara, K Kikuchi

CIRCULATION   104 ( 4 )   455 - 460   2001.7

Changes in caveolin subtype protein expression in aging rat organs Reviewed

J Kawabe, BS Grant, M Yamamoto, C Schwencke, S Okumura, Y Ishikawa

MOLECULAR AND CELLULAR ENDOCRINOLOGY   176 ( 1-2 )   91 - 95   2001.5

Pioglitazone enhances cytokine-induced apoptosis in vascular smooth muscle cells and reduces intimal hyperplasia. Reviewed

Aizawa Y, Kawabe J , Hasebe N, Takehara N, and Kikuchi K.

Circulation   104   455 - 460   2001.4

Changes in caveolin subtype protein expression in aging rat organs. Reviewed

Kawabe J , Grant BS, Yamamoto M, Schwencke C, Okumura S, and Ishikawa Y.

Mol Cell Endocrinol,   176   91 - 95   2001.4

Pioglitazone enhances cytokine-induced apoptosis in vascular smooth muscle cells and reduces intimal hyperplasia

Aizawa, Y. and Kawabe, J.-I. and Hasebe, N. and Takehara, N. and Kikuchi, K.

Circulation   104 ( 4 )   455 - 460   2001

Changes in caveolin subtype protein expression in aging rat organs

Kawabe, J.-I. and Grant, B.S. and Yamamoto, M. and Schwencke, C. and Okumura, S. and Ishikawa, Y.

Molecular and Cellular Endocrinology   176 ( 1-2 )   91 - 95   2001

Glucose modifies the cross-talk between insulin and the beta-adrenergic signalling system in vascular smooth muscle cells Reviewed

J Kawabe, Y Aizawa, N Takehara, N Hasebe, K Kikuchi

JOURNAL OF HYPERTENSION   18 ( 10 )   1457 - 1464   2000.10

High glucose attenuates insulin-induced mitogen-activated protein kinase phosphatase-1 (MKP-1) expression in vascular smooth muscle cells Reviewed

N Takehara, J Kawabe, Y Aizawa, N Hasebe, K Kikuchi

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH   1497 ( 2 )   244 - 252   2000.7

Glucose modifies the cross-talk between insulin and the beta-adrenergic ignaling system in vascular smooth muscle cells. Reviewed

Kawabe J , Aizawa Y, Takehara N, Hasebe N, and Kikuchi K.

J Hypertens,   18   1457 - 1464   2000.4

High glucose attenuates insulin-induced MKP-1 expression in vascular smooth muscle cells.. Reviewed

Takehara N, Kawabe J , Aizawa Y, Hasebe N, and Kikuchi K

Biochim Biophys Acta   1497   244 - 252   2000.4

High glucose attenuates insulin-induced mitogen-activated protein kinase phosphatase-1 (MKP-1) expression in vascular smooth muscle cells

Takehara, N. and Kawabe, J.-I. and Aizawa, Y. and Hasebe, N. and Kikuchi, K.

Biochimica et Biophysica Acta - Molecular Cell Research   1497 ( 2 )   244 - 252   2000

Glucose modifies the cross-talk between insulin and the β-adrenergic signalling system in vascular smooth muscle cells

Kawabe, J.-I. and Aizawa, Y. and Takehara, N. and Hasebe, N. and Kikuchi, K.

Journal of Hypertension   18 ( 10 )   1457 - 1464   2000

Lovastatin prevents angiotensin II-induced cardiac hypertrophy in cultured neonatal rat heart cells Reviewed

Shinji Oi, Takashi Haneda, Junzo Osaki, Yusuke Kashiwagi, Yasuhiro Nakamura, Junichi Kawabe, Kenjiro Kikuchi

European Journal of Pharmacology   376 ( 1-2 )   139 - 148   1999.7

Lovastatin prevents angiotensin II-induced cardiac hypertrophy in cultured neonatal rat heart cells. Reviewed

Oi S, Haneda T, Osaki J, Kashiwagi Y, Nakamura Y, Kawabe J , and Kikuchi K

Eur J Pharmacol,   376   139 - 148   1999.4

Lovastatin prevents angiotensin II-induced cardiac hypertrophy in cultured neonatal rat heart cells

Oi, S. and Haneda, T. and Osaki, J. and Kashiwagi, Y. and Nakamura, Y. and Kawabe, J. and Kikuchi, K.

European Journal of Pharmacology   376 ( 1-2 )   139 - 148   1999

Enhanced expression of heparin-binding EGF-like growth factor and its receptor in hypertrophied left ventricle of spontaneously hypertensive rats. Reviewed

Fujino T, Hasebe N, Fujita M, Takeuchi K, Kawabe J, Tobise K, Higashiyama S, Taniguchi N, Kikuchi K

Cardiovascular research   38 ( 2 )   365 - 374   1998.5

Enhanced expression of heparin-binding EGF-like growth factor and its receptor in hypertrophied left ventricle of SHR. Reviewed

Fujino T, Hasebe N, Fujita M, Takeuchi K, Kawabe J , Tobise K, Higashiyama S, Taniguchi N, and Kikuchi K.

Cardiovasc Res,   38   365 - 374   1998.4

Enhanced expression of heparin-binding EGF-like growth factor and its receptor in hypertrophied left ventricle of spontaneously hypertensive rats

Fujino, T. and Hasebe, N. and Fujita, M. and Takeuchi, K. and Kawabe, J.-I. and Tobise, K. and Higashiyama, S. and Taniguchi, N. and Kikuchi, K.

Cardiovascular Research   38 ( 2 )   365 - 374   1998

Caveolin interaction with protein kinase C - Isoenzyme-dependent regulation of kinase activity by the caveolin scaffolding domain peptide Reviewed

N Oka, M Yamamoto, C Schwencke, J Kawabe, T Ebina, S Ohno, J Couet, MP Lisanti, Y Ishikawa

JOURNAL OF BIOLOGICAL CHEMISTRY   272 ( 52 )   33416 - 33421   1997.12

Regulation of adenylyl cyclase isoforms by N-alkanols Reviewed

T Ebina, Y Toya, J Kawabe, Y Ishikawa

JOURNAL OF CELLULAR BIOCHEMISTRY   66 ( 4 )   450 - 456   1997.9

Regulation of adenylyl cyclase isoforms by N-alkanols Reviewed

Ebina T, Toya Y, Kawabe J, and Ishikawa Y.

J Cell Biochem   66   450 - 456   1997.4

Caveolin interaction with PKC. Isoenzyme-dependent regulation of kinase activity by the caveolin scaffolding domain peptide., Reviewed

Oka N, Yamamoto M, Schwencke C, Kawabe J, Ebina T, Ohno S, Couet J, Lisanti MP, and Ishikawa Y.

J Biol Chem   272   33416 - 33421   1997.4

Isoform-dependent activation of adenylyl cyclase by proteolysis. Reviewed

Ebina T, Toya Y, Oka N, Kawabe J, Schwencke C, and Ishikawa

FEBS Lett,   401   223 - 226   1997.4

Conformation-dependent activation of type II adenylyl cyclase by protein kinase C. Reviewed

Ebina T, Kawabe J, Katada T, Ohno S, Homcy CJ, and Ishikawa Y

J Cell Biochem   64   492 - 498   1997.4

Isoform-specific regulation of adenylyl cyclase by oxidized catecholamines., Reviewed

Ebina T, Toya Y, Oka N, Schwencke C, Kawabe J, and Ishikawa Y

J Mol Cell Cardiol   29   1247 - 1254   1997.4

Isoform specific regulation of adenylyl cyclase by oxidized catecholamines Reviewed

T Ebina, Y Toya, N Oka, C Schwencke, J Kawabe, Y Ishikawa

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY   29 ( 4 )   1247 - 1254   1997.4

Conformation-dependent activation of type II adenylyl cyclase by protein kinase C Reviewed

T Ebina, J Kawabe, T Katada, S Ohno, CJ Homcy, Y Ishikawa

JOURNAL OF CELLULAR BIOCHEMISTRY   64 ( 3 )   492 - 498   1997.3

Caveolin interaction with protein kinase C. Isoenzyme-dependent regulation of kinase activity by the caveolin scaffolding domain peptide

Oka, N. and Yamamoto, M. and Schwencke, C. and Kawabe, J.-I. and Ebina, T. and Ohno, S. and Couet, J. and Lisanti, M.P. and Ishikawa, Y.

Journal of Biological Chemistry   272 ( 52 )   33416 - 33421   1997

Erratum: Isoform-dependent activation of adenylyl cyclase by proteolysis (FEBS 18081) (FEBS Letters 401 (1997) (223-226) PII: S0014579396014755)

Ebina, T. and Toya, Y. and Oka, N. and Kawabe, J.-I. and Schwencke, C. and Ishikawa, Y.

FEBS Letters   411 ( 2-3 )   393 - 393   1997

Isoform-specific regulation of adenylyl cyclase by oxidized catecholamines

Ebina, T. and Toya, Y. and Oka, N. and Schwencke, C. and Kawabe, J.-I. and Ishikawa, Y.

Journal of Molecular and Cellular Cardiology   29 ( 4 )   1247 - 1254   1997

Secretion of atrial natriuretic peptide from the left ventricle and heart in patients with hypertrophic cardiomyopathy: relationship with hemodynamic and echocardiographic profiles

Ishii, Y. and Kawashima, E. and Kawabe, J. and Kikuchi, K.

Journal of cardiology   30 ( 1 )   19 - 28   1997

Isoform-dependent activation of adenylyl cyclase by proteolysis

Ebina, T. and Toya, Y. and Oka, N. and Kawabe, J.-I. and Schwencke, C. and Ishikawa, Y.

FEBS Letters   401 ( 2-3 )   223 - 226   1997

Conformation-dependent activation of type II adenylyl cyclase by protein kinase C

Ebina, T. and Kawabe, J.-I. and Katada, T. and Ohno, S. and Homcy, C.J. and Ishikawa, Y.

Journal of Cellular Biochemistry   64 ( 3 )   492 - 498   1997

Regulation of adenylyl cyclase isoforms by n-alkanols

Ebina, T. and Toya, Y. and Kawabe, J.-I. and Ishikawa, Y.

Journal of Cellular Biochemistry   66 ( 4 )   450 - 456   1997

Soluble adenylyl cyclase from Spodoptera frugiperda (Sf9) cells - Purification and biochemical characterization Reviewed

J Kawabe, Y Toya, C Schwencke, N Oka, T Ebina, Y Ishikawa

JOURNAL OF BIOLOGICAL CHEMISTRY   271 ( 33 )   20132 - 20137   1996.8

Soluble adenylyl cyclase from Spodoptera frugiperda (Sf9) cells. Purification and biochemical characterization. Reviewed

Kawabe J, 　Toya Y, Schwencke C, Oka N, Ebina T, and Ishikawa Y.

J Biol Chem   271   20132 - 20137   1996.4

Regulation of type V adenylyl cyclase by PMA-sensitive and –insensitive protein kinase C isoenzymes in intact cells. Reviewed

Kawabe J, Ebina T, Toya Y, Oka N, Schwencke C, Duzic E, and Ishikawa Y.

FEBS Lett,   384   273 - 276   1996.4

Regulation of type V adenylyl cyclase by PMA-sensitive and -insensitive protein kinase C isoenzymes in intact cells Reviewed

J Kawabe, T Ebina, Y Toya, N Oka, C Schwencke, E Duzic, Y Ishikawa

FEBS LETTERS   384 ( 3 )   273 - 276   1996.4

Soluble adenylyl cyclase from Spodoptera frugiperda (Sf9) cells: Purification and biochemical characterization

Kawabe, J.-I. and Toya, Y. and Schwencke, G. and Oka, N. and Ebina, T. and Ishikawa, Y.

Journal of Biological Chemistry   271 ( 33 )   20132 - 20137   1996

Errata: Erratum to 'Multiplicity in type V adenylylcyclase: Type V-a and type V-b' (Molecular and Cellular Endocrinology 110 (1995) 45)

Iwami, G. and Akanuma, M. and Kawabe, J. and Cannon, P.J. and Homcy, C.J. and Ishikawa, Y.

Molecular and Cellular Endocrinology   122 ( 1 )   111 - 112   1996

Regulation of type V adenylyl cyclase by PMA-sensitive and -insensitive protein kinase C isoenzymes in intact cells

Kawabe, J.-I. and Ebina, T. and Toya, Y. and Oka, N. and Schwencke, G. and Duzic, E. and Ishikawa, Y.

FEBS Letters   384 ( 3 )   273 - 276   1996

REGULATION OF ADENYLYL-CYCLASE BY PROTEIN-KINASE-A Reviewed

G IWAMI, J KAWABE, T EBINA, PJ CANNON, CJ HOMCY, Y ISHIKAWA

JOURNAL OF BIOLOGICAL CHEMISTRY   270 ( 21 )   12481 - 12484   1995.5

Regulation of adenylyl cyclase by protein kinase A. Reviewed

Iwami G, Kawabe J, Ebina T, Cannon PJ, Homcy CJ, and Ishikawa Y.

J Biol Chem   270   12481 - 12484   1995.4

Multiplicity in type V adenylylcyclase: type V-a and type V-b., Reviewed

Iwami G, Akanuma M, Kawabe J,　Cannon PJ, Homcy CJ, and Ishikawa Y.

Mol Cell Endocrinol   110   43 - 47   1995.4

Multiplicity in type V adenylylcyclase: type V-a and type V-b

Iwami, G. and Akanuma, M. and Kawabe, J. and Cannon, P.J. and Homcy, C.J. and Ishikawa, Y.

Molecular and Cellular Endocrinology   110 ( 1-2 )   43 - 47   1995

Regulation of adenylyl cyclase by protein kinase A

Iwami, G. and Kawabe, J.-I. and Ebina, T. and Cannon, P.J. and Homcy, C.J. and Ishikawa, Y.

Journal of Biological Chemistry   270 ( 21 )   12481 - 12484   1995

DIFFERENTIAL ACTIVATION OF ADENYLYL-CYCLASE BY PROTEIN-KINASE-C ISOENZYMES Reviewed

J KAWABE, G IWAMI, T EBINA, S OHNO, T KATADA, Y UEDA, CJ HOMCY, Y ISHIKAWA

JOURNAL OF BIOLOGICAL CHEMISTRY   269 ( 24 )   16554 - 16558   1994.6

A novel peptide inhibitor of adenylyl cyclase (AC). A peptide from type V AC directly inhibits AC catalytic activity. Reviewed

Kawabe J, Ebina T, Ismail S, Kitchen DB, Homcy CJ, and Ishikawa Y

J Biol Chem   269   24906 - 24911   1994.4

Differential activation of adenylyl cyclase by protein kinase C isoenzymes. Reviewed

Kawabe J, Iwami G, Ebina T, Ohno S, Katada T, Ueda Y, Homcy CJ, and Ishikawa Y.

J Biol Chem   269   6554 - 6558   1994.4

Differential activation of adenylyl cyclase by protein kinase C isoenzymes

Kawabe, J.-I. and Iwami, G. and Ebina, T. and Ohno, S. and Katada, T. and Ueda, Y. and Homcy, C.J. and Ishikawa, Y.

Journal of Biological Chemistry   269 ( 24 )   16554 - 16558   1994

Erratum: Differential activation of adenylyl cyclase by protein kinase C isoenzymes (Journal of Biological Chemistry (1994) 269 (16554-16558))

Kawabe, J.-I. and Iwami, G. and Ebina, T. and Ohno, S. and Katada, T. and Ueda, Y. and Homcy, C.J. and Ishikawa, Y.

Journal of Biological Chemistry   269 ( 36 )   22912 - 22912   1994

A novel peptide inhibitor of adenylyl cyclase (AC). A peptide from type V AC directly inhibits AC catalytic activity

Kawabe, J.-I. and Ebina, T. and Ismail, S. and Kitchen, D.B. and Homey, C.J. and Ishikawa, Y.

Journal of Biological Chemistry   269 ( 40 )   24906 - 24911   1994

In vivo generation of an adenylylcyclase isoform with a half-molecule motif. Reviewed

Katsushika S, Kawabe J, Homcy CJ, and Ishikawa Y.

J Biol Chem   268   2273 - 2276   1993.4

Adenylylcyclase: characterization in the heart and its regulation in heart failure. Reviewed

Homcy CJ, Katsushika S, Kawabe J. et al

Hypertens Res   16   79 - 83   1993.4

In vivo generation of an adenylylcyclase isoform with a half-molecule motif

Katsushika, S. and Kawabe, J.-I. and Homcy, C.J. and Ishikawa, Y.

Journal of Biological Chemistry   268 ( 4 )   2273 - 2276   1993

Adenylylcyclase: Characterization in the Heart and Its Regulation in Heart Failure

Homcy, C.J. and Ishikawa, Y. and Katsushika, S. and Kawabe, J.-I. and Ishikawa, Y. and Kiuchi, K. and Komamura, K. and Vatner, D.E. and Vatner, S.F.

Hypertension Research   16 ( 2 )   79 - 83   1993

Role of endothelium in biphasic hypoxic response of the isolated poumonary artery in the rat

Ogawa, Y. and Kawabe, J.-I. and Onodera, S. and Tobise, K. and Morita, K. and Harada, T. and Hirayama, T. and Takeda, A.

JAPANESE CIRCULATION JOURNAL   57 ( 3 )   228 - 236   1993

Adenylylcyclase: Characterization in the Heart and Its Regulation in Heart Failure.

Homcy Charles J., Katsushika Shuichi, Kawabe Jun-ichi, Kiuchi Kaname, Komamura Kazuo, Vatner Dorothy E., Vatner Stephen F., Ishikawa Yoshihiro

Hypertension Research   16 ( 2 )   79 - 83   1993

Down-regulation of protein kinase C potentiates atrial natriuretic peptide-stimulated cGMP accumulation in vascular smooth-muscle cells Reviewed

Jun-ichi Kawabe, Yoshinobu Ohsaki, Sokichi Onodera

BBA - Molecular Cell Research   1175 ( 1 )   81 - 87   1992.12

DOWN-REGULATION OF PROTEIN-KINASE-C POTENTIATES ATRIAL NATRIURETIC PEPTIDE-STIMULATED CGMP ACCUMULATION IN VASCULAR SMOOTH-MUSCLE CELLS Reviewed

J KAWABE, Y OHSAKI, S ONODERA

BIOCHIMICA ET BIOPHYSICA ACTA   1175 ( 1 )   81 - 87   1992.12

CLONING AND CHARACTERIZATION OF A 6TH ADENYLYL CYCLASE ISOFORM - TYPE-V AND TYPE-VI CONSTITUTE A SUBGROUP WITHIN THE MAMMALIAN ADENYLYL CYCLASE FAMILY Reviewed

S KATSUSHIKA, L CHEN, JI KAWABE, R NILAKANTAN, NJ HALNON, CJ HOMCY, Y ISHIKAWA

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   89 ( 18 )   8774 - 8778   1992.9

ISOLATION AND CHARACTERIZATION OF A NOVEL CARDIAC ADENYLYLCYCLASE CDNA Reviewed

Y ISHIKAWA, S KATSUSHIKA, L CHEN, NJ HALNON, J KAWABE, CJ HOMCY

JOURNAL OF BIOLOGICAL CHEMISTRY   267 ( 19 )   13553 - 13557   1992.7

Isolation and characterization of a novel cardiac adenylylcyclase cDNA. Reviewed

Ishikawa Y, Katsushika S, Chen L, Halnon NJ, Kawabe J , and Homcy CJ.

J Biol Chem   267   13553 - 13557   1992.4

Down-regulation of PKC potentiates ANP-stimulated cGMP accumulation in vascular smooth-muscle cells., Reviewed

Kawabe J, Ohsaki Y, and Onodera S.

Biochim Biophys Acta   1175   81 - 87   1992.4

Cloning and characterization of a sixth AC isoform: types V and VI constitute a subgroup within the mammalian AC family　 Reviewed

Katsushika S, Chen L, Kawabe J , Nilakantan R, Halnon NJ, Homcy CJ, and Ishikawa Y.

Proc Natl Acad Sci U S A   89   8774 - 8778   1992.4

Down-regulation of protein kinase C potentiates atrial natriuretic peptide-stimulated cGMP accumulation in vascular smooth-muscle cells

Kawabe, J.-i. and Ohsaki, Y. and Onodera, S.

BBA - Molecular Cell Research   1175 ( 1 )   81 - 87   1992

Role of endothelium in hypoxia-induced contraction of isolated rat pulmonary artery

Ogawa, Y. and Kawabe, J. and Morita, K. and Harada, T. and Hirayama, T. and Takeda, A. and Tobise, K. and Onodera, S.

Japanese Journal of Pharmacology   58 ( SUPPL. 2 )   1992

Cloning and characterization of a sixth adenylyl cyclase isoform: Types V and VI constitute a subgroup within the mammalian adenylyl cyclase family

Katsushika, S. and Chen, L. and Kawabe, J.-I. and Nilakantan, R. and Halnon, N.J. and Homcy, C.J. and Ishikawa, Y.

Proceedings of the National Academy of Sciences of the United States of America   89 ( 18 )   8774 - 8778   1992

Isolation and characterization of a novel cardiac adenylylcyclase cDNA

Ishikawa, Y. and Katsushika, S. and Chen, L. and Halnon, N.J. and Kawabe, J.-I. and Homcy, C.J.

Journal of Biological Chemistry   267 ( 19 )   13553 - 13557   1992

The Combination Effect of Caffeine and Cisplatin on a Human Lung Cancer Cell Line

Yoshinobu, O, I. and Toshiaki, F. and Jun-ichi, K. and Hiroyuki, M. and Sokichi, O.

Japanese Journal of Lung Cancer   30 ( 3 )   341 - 349   1990

Effects of chronic volume loading on atrial natriuretic peptide release in human

Kawabe, J. and Ohsaki, Y. and Onodera, S. and Inoue, H. and Hirayama, T. and Akiba, Y. and Osanai, S. and Sakai, H. and Ishida, S. and Nakano, H.

Kokyu to junkan. Respiration &amp; circulation   38 ( 11 )   1121 - 1125   1990

Cefdinir in respiratory tract infection

Matsumoto, H. and Akiba, Y. and Osanai, S. and Ishida, S. and Kawabe, J. and Osaki, Y. and Fujikane, T. and Sasakli, N. and Onodera, S. and Nakano, H.

CHEMOTHERAPY   37   257 - 262   1989

最新の治療ストラテジー　ベーターブロッカーの使い方　臨床雑誌内科

竹原有史、川辺淳一、長谷部直幸、菊池健次郎（ Role： Joint author）

南江堂  2000.4 

Ninjurin1, a Novel Regulatory Factor of Pericytes to Interact With Endothelial Cells, Mediates the Circulation Recovery in the Hind Limb Ischemia

Motoki Matsuki, Jun-ichi Kawabe, Tatsuya Aonuma, Maki Kabara, Atsushi Yamauchi, Kohei Shimamura, Akiho Minoshima, Naofumi Takehara, Yukihiro Saito, Naoyuki Hasebe

CIRCULATION   130   2014.11

Abrogation of miR-195 Improves Function in Aged Heart by Preventing Telomere Shortening and Mitochondrial Dysfunction

Motoi Okada, Hawon Kim, Muhammad Ashraf, Jun-ichi Kawabe, Naoyuki Hasebe

CIRCULATION   130   2014.11

Microalbuminuria Associated with Functionally Impaired Endothelial Progenitor Cells Predicts In-Stent Late Loss via Cellular Senescence after Myocardial Infarction

Hisanobu Ota, Naofumi Takehara, Naoki Nakagawa, Toshiharu Takeuchi, Jun-ichi Kawabe, Naoyuki Hasebe

CIRCULATION   126 ( 21 )   2012.11

Functional disorder of endothelial progenitor cells enhance microalbuminuria predicting in-stent late loss in acute myocardial infarction

H. Ota, N. Takehara, N. Nakagawa, T. Takeuchi, J. Kawabe, N. Hasebe

EUROPEAN HEART JOURNAL   33   598 - 599   2012.8

ベラプロスト投与による肺癌の転移抑制効果(Administration of Beraprost inhibited metastasis in lung cancer)

南 幸範, 遠藤 哲史, 澁川 紀代子, 佐々木 高明, 川辺 淳一, 北田 正博, 大崎 能伸

日本癌学会総会記事   71回   397 - 397   2012.8

Peripheral Nerve is Critical for Vasa Vasorum Maturation in Injured Vascular Walls. -Effects of Substance P on Pericytes-Mediated Vascular Maturation

Akira Asanome, Jun-ichi Kawabe, Maki Kabara, Motoki Matsuki, Atsushi Yamauchi, Naoki Nakagawa, Hisanobu Ota, Naofumi Takehara, Hiroki Bochimoto, Yoshiki Hira, Naoyuki Hasebe

CIRCULATION   124 ( 21 )   2011.11

肺癌肺転移の制御機構とプロスタグランジンI2シグナルの検討

南 幸範, 遠藤 哲史, 奥村 俊介, 澁川 紀代子, 佐々木 高明, 川辺 淳一, 北田 正博, 大崎 能伸

肺癌   51 ( 5 )   425 - 425   2011.10

Prostaglandin I-2 signaling regulates micro-metastasis in lung cancer

Yoshinori Minami, Shunsuke Okumura, Takaaki Sasaki, Junichi Kawabe, Satoshi Endo, Kazuhiro Satoh, Masahiro Kitada, Yuka Fujita, Naoyuki Hasebe, Yoshinobu Ohsaki

CANCER RESEARCH   71   2011.4

血管新生研究における電子顕微鏡観察法の重要性

川辺淳一, 暮地本宙己, 平義樹, 渡部剛

日本顕微鏡学会北海道支部学術講演会講演要旨集   2011   9   2011

Enhanced inhibition of Neointimal Hyperplasia by Overexpression of Apurinic/apyrimidinic Endonuclease (APE1) in Endothelial Progenitor Cells

Atsushi Yamauchi, Junichi Kawabe, Hiroshi Koike, Akira Asanome, Motoki Matsuki, Naoki Nakagawa, Naohumi Takehara, Motoi Okada, Naoyuki Hasebe

CIRCULATION   122 ( 21 )   2010.11

プロスタグランジンI2受容体阻害剤封入PLGAナノ粒子を用いた肺癌肺転移抑制効果の検討

南 幸範, 奥村 俊介, 川辺 淳一, 佐々木 高明, 北田 正博, 長谷部 直幸, 大崎 能伸

肺癌   50 ( 5 )   509 - 509   2010.10

Prostacyclin in Vascular Disease; Recent Insights and Future Perspectives

Kawabe J. Ushikubi F, Hasebe N

Circ Res   74 ( (5) )   836 - 843   2010.4

Roles of Prostanoids in the Pathogenesis of Cardiovascular Diseases

Yuhki　K, Kashiwagi　H, Kojima　F, Kawabe　J and Ushikubi　F

International Angiology   29   19 - 27   2010.4

Roles of prostanoids in the pathogenesis of cardiovascular diseases

K. Yuhki, H. Kashiwagi, F. Kojima, J. Kawabe, F. Ushikubi

INTERNATIONAL ANGIOLOGY   29 ( 2 )   19 - 27   2010.4

The Cardioprotective Effect of Prostaglandin E-2/EP4 System is Important for the Late Phase Preconditioning

Takayasu Kanno, Jun-ichi Kawabe, Koh-ichi Yuhki, Naofumi Takehara, Fumitaka Ushikubi, Naoyuki Hasebe

CIRCULATION   120 ( 18 )   S784 - S784   2009.11

Hedgehog Promotes Neovascularization through the Regulation of Bone-Marrow Derived Progenitors

Yusuke Mizukami, Junpei Sasajima, Kazumasa Nakamura, Kazuya Sato, Yoshiaki Sugiyama, Madoka Yamazaki, Toru Kawamoto, Kazuya Koizumi, Katsunori Sasaki, Mikihiro Fujiya, Satoshi Tanno, Toshikatsu Okumura, Norihiko Shimizu, Jun-ichi Kawabe, Toru Kono, Yoshihiro Torimoto, Masaaki Ii, Nabeei Bardeesy, Daniel C. Chung, Yutaka Kohgo

BLOOD   114 ( 22 )   1187 - 1187   2009.11

Prostacyclin Relieves Peripheral Ischemia Through Enhancement of Critical Functions of Hematopoietic Stem Cells

Motoi Okada, Jun-Ichi Kawabe, Yoko Aburakawa, Takayasu Kanno, Motoi Kobayashi, Atsushi Yamauchi, Naoki Nakagawa, Naofumi Takehara, Fumitaka Ushikubi, Naoyuki Hasebe

JOURNAL OF CARDIAC FAILURE   15 ( 7 )   S182 - S182   2009.9

The tumor vasculature is a paracrine target of Hedgehog in pancreatic cancer

Junpei Sasajima, Yusuke Mizukami, Kazumasa Nakamura, Yoshiaki Sugiyama, Madoka Yamazaki, Kazuya Sato, Mikihiro Fujiya, Jun-ichi Kawabe, Satoshi Tanno, Toshikatsu Okumura, Toru Kono, Masaaki Ii, Nabeel Bardeesy, Daniel Chung, Yutaka Kohgo

CANCER RESEARCH   69   2009.5

プロスタサイクリンによる血管内皮前駆細胞機能調節と血管保護への影響

川辺淳一

血栓と循環   17 ( (4) )   86 - 87   2009.4

OE-299 Prostacyclin Augments Endothelial Progenitor Cell Functions and Rescue Peripheral Ischemia(OE51,Peripheral Circulation/Vascular Disease (Pathophysiology, Basic) (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

Okada Motoi, Kawabe Junichi, Aburakawa Yoko, Kanno Takayasu, Yamauchi Atsushi, Yamaki Masaru, Nakagawa Naoki, Takehara Naofumi, Ushikubi Fumitaka, Hasebe Naoyuki

Circulation journal : official journal of the Japanese Circulation Society   73   250 - 250   2009.3

OE-056 Prostacyclin System in Endothelial Progenitor Cells is Crucial for Regulation of Vascular Remodeling through Their Recruitment to Injured Vascular Walls(OE10,Atherosclerosis, Basic 1 (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

Yamauchi Atsushi, Kawabe Junichi, Kobayashi Motoi, Kanno Takayasu, Yamaki Masaru, Nakagawa Naoki, Ohta Hisanobu, Takehara Naofumi, Okada Motoi, Ushikubi Fumitaka, Hasebe Naoyuki

Circulation journal : official journal of the Japanese Circulation Society   73   188 - 188   2009.3

Nitric oxide (NO) plays a role in inflammatory tachycardia

Asako Kanai, Koh-ichi Yuhki, Jun-ichi Kawabe, Yasuhiro Suzuki, Hitoshi Kashiwagi, Kazuo Sengoku, Shuh Narumiya, Fumitaka Ushikubi

JOURNAL OF PHARMACOLOGICAL SCIENCES   109   69P - 69P   2009

P-55 非小細胞肺癌に対するアディポカインの抗腫瘍効果の検討(分子生物学,第49回日本肺癌学会総会号)

奥村 俊介, 佐々木 高明, 長内 忍, 川辺 淳一, 大崎 能伸

肺癌   48 ( 5 )   2008.10

Prostacyclin Relieves Peripheral Ischemia through Enhancement of Critical Functions of Endothelial Progenitor Cells

Motoi Okada, Jun-ichi Kawabe, Yoko Aburakawa, Takayasu Kanno, Atsushi Yamauchi, Naoki Nakagawa, Naohiko Tashiro, Masaru Yamaki, Fumitaka Ushikubi, Naoyuki Hasebe

CIRCULATION   118 ( 18 )   S479 - S480   2008.10

OE-094 Decreased Susceptibility to Release of TGF-β1 from Platelet and Microalbuminuria in TXA2 Receptor Deficient Mice with Diabetes Mellitus(Diabetes/Obesity/Metabolic syndrome(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Fujino Takayuki, Suzuki Yasuhiro, Kawabe Jun-ichi, Yuhki Kou-ichi, Fukuzawa Jun, Matsuki Motoki, Nakagawa Naoki, Hasebe Naoyuki, Ushikubi Fumitaka

Circulation journal : official journal of the Japanese Circulation Society   72   203 - 203   2008.3

PE-570 Role of Autocrine Prostacyclin System in Crucial Functions of Endothelial Progenitor Cells.(Regeneration(angiogenesis/myocardial regeneration)(03)(M),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Kawabe Jun-ichi, Kanno Takayasu, Tashiro Naohiko, Okada Motoi, Yuhki Koh-ichi, Ushikubi Fumitaka, Hasebe Naoyuki

Circulation journal : official journal of the Japanese Circulation Society   72   503 - 503   2008.3

Role of endogenous prostaglandin I-2 in the progression of vascular remodeling

Osamu Takahata, Koh-ichi Yuhki, Jun-ichi Kawabe, Yasuhiro Suzuki, Hiroshi Iwasaki, Shuh Narumiya, Fumitaka Ushikubi

JOURNAL OF PHARMACOLOGICAL SCIENCES   106   113P - 113P   2008

WS9-1 骨髄由来血管内皮前駆細胞の制御による腫瘍増殖の抑制 : 小細胞肺癌の治療への応用(ワークショップ 肺癌研究:基礎から臨床へ,第48回日本肺癌学会総会号)

佐々木 高明, 奥村 俊介, 渋川 紀代子, 長内 忍, 川辺 淳一, 大崎 能伸

肺癌   47 ( 5 )   2007.10

Deletion of prostacyclin-receptor in bone marrow attenuates differentiation of endothelial progenitor cells, and enhances vascular intimal hyperplasia

Jun-ichi Kawabe, Koh-ichi Yuhki, Takayasu Kannno, Naoyuki Hasebe, Fumitaka Ushikubi

CIRCULATION   116 ( 16 )   268 - 268   2007.10

肺癌研究 基礎から臨床へ 骨髄由来血管内皮前駆細胞の制御による腫瘍増殖の抑制 小細胞肺癌の治療への応用

佐々木 高明, 奥村 俊介, 渋川 紀代子, 長内 忍, 川辺 淳一, 大崎 能伸

肺癌   47 ( 5 )   464 - 464   2007.10

OE-013 Decreased Susceptibility to Glomerular Regeneration in Thromboxane A2 Receptor Deficient Mice(Kidney/Renal circulation-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

Fujino Takayuki, Abe Kazutoshi, Nakagawa Naoki, Yuhki Kou-ichi, Kawabe Jun-ichi, Hasebe Naoyuki, Kikuchi Kenjiro, Ushikubi Fumitaka

Circulation journal : official journal of the Japanese Circulation Society   71   155 - 155   2007.3

FRS-050 Deletion of PGI_2-receptor (IP) in Bone Marrow Enhances Progenitor Cells-Mediated Vascular Intimal Hyperplasia(Vascular Injury and Neointimal Formation in Animal Models (basic), The 71st Annual Scientific Meeting of the Japanese Circulation Society)

Kawabe Jun-ichi, Kanno Takayasu, Yuhki Ko-ichi, Hasebe Naoyuki, Kikuchi Kenjiro, Usikubi Fumitaka

Circulation journal : official journal of the Japanese Circulation Society   71   129 - 129   2007.3

PJ-220 Pitavastatin Attenuates Cytokine-induced Monocyte/Macrophage Activation and Oxidative Stress through the Heat Shock Protein 72 Expression(Atherosclerosis, basic-9, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

Okada Motoi, Hasebe Naoyuki, Tashiro Naohiko, Yamauchi Atsushi, Kawabe Junichi, Kikuchi Kenjiro

Circulation journal : official journal of the Japanese Circulation Society   71   526 - 526   2007.3

プロスタグランジンE2はその受容体サブタイプEP3を介して虚血-再灌流傷害から心臓を保護する(Prostaglandin E2 protects the heart from ischemia-reperfusion injury via its receptor subtype EP3)

Yuhki Koh-ichi, Xiao Chun Yang, Hara Akiyoshi, Kawabe Jun-ichi, Narumiya Shuh, Ushikubi Fumitaka

Journal of Pharmacological Sciences   103 ( Suppl.I )   113 - 113   2007.2

Role of prostacyclin in differentiation of endothelial progenitor cells and vascular remodeling

Jun-ichi Kawabe, Ko-ichi Yuhki, Naoyuki Hasebe, Shuh Narumiya, Fumitaka Ushikubi

JOURNAL OF PHARMACOLOGICAL SCIENCES   103   245P - 245P   2007

Repeated thermal treatment reduces adventitial inflammatory response in arteriosclerosis

Motoi Okada, Naoyuki Hasebe, Naohiko Tashiro, Atsushi Yamauchi, Jun-ichi Kawabe, Kenjirou Kikuchi

JOURNAL OF HYPERTENSION   24   70 - 70   2006.12

Decreased susceptibility to glomerular hypertrophy and albuminuria in thromboxane A(2) receptor deficient mice

Takayuki Fujino, Kazutoshi Abe, Naoki Nakagawa, Kohichi Yuhki, Junichi Kawabe, Jun Fukuzawa, Naoyuki Hasebe, Kenjiro Kikuchi, Shuh Narumiya, Fumitaka Ushikubi

JOURNAL OF HYPERTENSION   24   293 - 293   2006.12

Combination of pitavastatin and thermal treatment attenuates cytokine-induced monocye/macrophage activation and oxidative stress.

Motoi Okada, Naoyuki Hasebe, Naohiko Tashiro, Atsushi Yamauchi, Jun-ichi Kawabe, Kenjirou Kikuchi

JOURNAL OF HYPERTENSION   24   393 - 393   2006.12

Combination of pitavastatin and thermal treatment attenuates angiotensin II induced cellular activation and oxidative stress

M. Okada, N. Hasebe, J. Kawabe, N. Tashiro, K. Kikuchi

JOURNAL OF HYPERTENSION   24   S376 - S376   2006.6

Thermal treatment attenuates vascular oxidative stress and lowers blood pressure in spontaneously hypertensive rats

N. Tashiro, M. Okada, K. Izawa, Y. Aizawa, J. Kawabe, N. Hasebe, K. Kikuchi

JOURNAL OF HYPERTENSION   24   S374 - S374   2006.6

Role of prostanoids in inflammatory tachycardia: A reply to the letter of Dr. Eugene Nalivaiko

K Yuhki, J Kawabe, F Ushikubi

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY   290 ( 6 )   R1751 - R1751   2006.6

心血管系におけるプロスタノイドの役割　　　　

結城幸一、藤野貴行、高山浩二、川辺淳一、牛首文隆

生体の科学   57 ( (6) )   598 - 601   2006.4

カルシウム拮抗薬の特徴と使用法　　　

川辺淳一、長谷部直幸、菊池健次郎

診断と治療   94 ( (3) )   391 - 395   2006.4

PE-520 Combination of Pitavastatin and Thermal Treatment Attenuates Angiotensin II-induced Cellular Activation and Oxidative Stress(Peripheral circulation-3 (H) PE87,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

Okada Motoi, Tashiro Naohiko, Izawa Kazuma, Kawabe Junichi, Hasebe Naoyuki, Kikuchi Kenjiro

Circulation journal : official journal of the Japanese Circulation Society   70   462 - 463   2006.3

プロスタグランジンE2はマウス脳血栓症モデルにおいてEP4を介して虚血障害を悪化させる(Prostaglandin E2 aggravates ischemic injury via EP4 in a murine model of cerebral thrombosis)

Ri Akimasa, Yuhki Koh-ichi, Kawabe Jun-ichi, Hara Akiyoshi, Hosoki Yayoi, Takahata Osamu, Iwasaki Hiroshi, Narumiya Shuh, Ushikubi Fumitaka

Journal of Pharmacological Sciences   100 ( Suppl.I )   261P - 261P   2006.2

Roles of the prostanoids in the cardiovascular system

K Yuhki, J Kawabe, O Takahata, A Hara, S Narumiya, F Ushikubi

JOURNAL OF PHARMACOLOGICAL SCIENCES   100   43P - 43P   2006

Disruption of type 5 adenylyl cyclase enhances desensitization of the camp signal and increases the Akt signal following chronic catecholamine stress, protecting myocyte viability

S Okumura, J Liu, GP Yang, C Ulucan, T Tsunematsu, J Kawabe, Y Ishikawa

CIRCULATION   112 ( 17 )   U313 - U313   2005.10

Paradoxical Suppression of Angiotensin II-induced Vascular Remodeling in Impaired Glutathione Redox System(Atherosclerosis, Basic 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

Izawa Kazuma, Izawa Kazuma, Hasebe Naoyuki, Okada Motoi, Sumitomo Kazuhiro, Kawabe Junichi, Nakagawa Naoki, Kikuchi Kenjiro

Circulation journal : official journal of the Japanese Circulation Society   69   482 - 482   2005.3

温熱による新生内膜脂厚の抑制効果－熱ショック蛋白の発現と酸化ストレスの抑制と役割－　

岡田　基、長谷部直幸、会澤佳昭、井澤和眞、川辺淳一、菊池健次郎

血　圧   11   263 - 266   2004.4

JNC７の長所と短所　　　　　　　　　　　　　　　　　　　　　　　　

川辺淳一、長谷部直幸、菊池健次郎

循環器内科   56 ( (5) )   507 - 511   2004.4

FRS-018 The Type 5 Adenylyl Cyclase Mediates Ca^<2+>-mediated Regulation of Ca^<2+> channels in the Heart(Cardiac Hypertrophy (M) : FRS3)(Featured Research Session (English))

Ishikawa Yoshihiro, Yatani Atsuko, Kawabe Junichi, Takano Teruo, Okumura Satoshi

Circulation journal : official journal of the Japanese Circulation Society   68   94 - 94   2004.3

OJ-513 Caveolin Modulates Microtubule Polymerization in Vascular Smooth Muscle Cells (VSMC)(Vascular Smooth Muscle 2 (H) : OJ63)(Oral Presentation (Japanese))

Kawabe Junichi, Ishikawa Yoshihiro, Hasebe Naoyuki, Kikuchi Kenjiro

Circulation journal : official journal of the Japanese Circulation Society   68   355 - 355   2004.3

OJ-514 Translocation of Caveolin Regulates Stretch-Induced Extracellular Signal-Regulated Kinase (ERK) Activity in Vascular Smooth Muscle Cells (VSMC)(Vascular Smooth Muscle 2 (H) : OJ63)(Oral Presentation (Japanese))

Kawabe Junichi, Ishikawa Yoshihiro, Hasebe Naoyuki, Kikuchi Kenjiro

Circulation journal : official journal of the Japanese Circulation Society   68   355 - 355   2004.3

OE-109 Disruption of the Type 5 Adenylyl Cyclase Gene Preserves Cardiac Function Against Pressure Overload(Heart Failure, Basic 1 (M) : OE13)(Oral Presentation (English))

Okumura Satoshi, Kawabe Junichi, Takagi Gen, Takano Teruo, Ishikawa Yoshihiro

Circulation journal : official journal of the Japanese Circulation Society   68   167 - 167   2004.3

PE-094 β-adrenergic and Muscarinic Regulation of the Heart Requires Type 5 Adenylyl Cyclase(Autonomic Nervous System 1 (H) : PE16)(Poster Session (English))

Okumura Satoshi, Kawabe Junichi, Takagi Gen, Takano Teruo, Ishikawa Yoshihiro

Circulation journal : official journal of the Japanese Circulation Society   68   385 - 385   2004.3

Caveolin-3 overexpression stimulates insulin signal in hepatic cells

K Otsu, J Oshikawa, J Kawabe, Y Ishikawa

FASEB JOURNAL   18 ( 4 )   A137 - A137   2004.3

Effects of chronic beta-adrenergic receptor stimulation in type 5 adenylyl cyclase-null mice

S Okumura, J Kawabe, GP Yang, L Jing, J Sadoshima, SF Vatner, Y Ishikawa

CIRCULATION   108 ( 17 )   48 - 48   2003.10

Coordinated motor dysfunction in type 5 adenylyl-cyclase deficient mice

T Iwamoto, S Okumura, K Iwatsubo, J Kawabe, Y Toya, S Umemura, N Arai, Y Goshima, CJ Homcy, SF Vatner, Y Ishikawa

FASEB JOURNAL   17 ( 4 )   A204 - A204   2003.3

Adenylyl cyclase type 5 disruption preserves cardiac function in response to pressure overload

G Takagi, S Okumara, J Kawabe, C Hong, GP Yang, T Meguro, Takagi, I, A Yatani, Gaussin, V, DE Vatner, J Sadoshima, CJ Homcy, Y Ishikawa, SF Vatner

CIRCULATION   106 ( 19 )   59 - 59   2002.11

beta-adrenergic, muscarinic and calcium-mediated regulation of the heart, effects of target disruption of type 5 adenylyl cyclase gene

S Okumura, J Kawabe, G Takagi, MC Lee, C Hong, J Liu, R Honda, Takagi, I, A Yatani, DE Vatner, CJ Homcy, SF Vatner

CIRCULATION   106 ( 19 )   67 - 67   2002.11

Blunted autonomic regulation in the hearts of type 5 adenylyl cyclase null mice

S Okumura, G Takagi, J Kawabe, L Lee, C Hong, R Honda, Takagi, I, J Sadoshima, A Yatani, DE Vatner, CJ Homcy, SF Vatner, Y Ishikawa

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY   29 ( 8 )   A78 - A78   2002.8

Translocation of caveolin regulates stretch-mediated extracellular signal-regulated kinase (ERK) activity in vascular smooth muscle cells

J Kawabe, S Okumura, LMC Lee, Y Ishikawa

FASEB JOURNAL   16 ( 4 )   A98 - A98   2002.3

Loss of muscarinic regulation in the heart of type V adenylyl cyclase knockout mice

S Okumura, J Kawabe, G Takagi, L Lee, C Hong, Takagi, I, A Yatani, DE Vatner, CJ Homcy, SF Vatner, Y Ishikawa

FASEB JOURNAL   16 ( 5 )   A821 - A821   2002.3

A novel sodium channel mutation in a variant form of Brugada syndrome

N Takehara, JI Kawabe, N Sato, Y Kawamura, N Hasebe, K Kikuchi, N Makita

CIRCULATION   102 ( 18 )   677 - 677   2000.10

IS141 Enhanced Expression of Heparin-binding EGF-like Growth Factor and Its Receptor in Hypertrophied Left Ventricle of Spontaneously Hypertensive Rats

Fujino Takayuki, Hasebe Naoyuki, Fujita Masaaki, Takeuchi Katsuro, Kawabe Jun-Ichi, Tobise Katsuyuki, Kikuchi Kenjirou

Japanese circulation journal   64   163 - 163   2000.3

High glucose attenuates insulin-induced mitogen activated protein kinase phosphatase-1 (MKP-1) expression in vascular smooth muscle cells

N Takehara, JI Kawabe, Y Aizawa, N Hasebe, K Kikuchi

JOURNAL OF HYPERTENSION   18   S130 - S130   2000

A HMG-CoA reductase inhibitor, lovastatin, prevents angiotensin II induced cardiac hypertrophy through p21(ras) MAP kinase pathway

T Haneda, S Oi, J Osaki, Y Kashiwagi, Y Nakamura, J Kawabe, K Okamoto, K Kikuchi

JOURNAL OF HYPERTENSION   16   S43 - S43   1998.6

Role of glucose in cross-talk of insulin with beta-adrenergic signaling in vascular smooth muscle cells

JI Kawabe, N Hasebe, Y Ogawa, K Kikuchi

JOURNAL OF HYPERTENSION   16   S159 - S159   1998.6

Isoform-dependent activation of adenylyl cyclase by proteolysis (vol 401, pg 223, 1997)

T Ebina, Y Toya, N Oka, J Kawabe, C Schwencke, Y Ishikawa

FEBS LETTERS   411 ( 2-3 )   393 - 393   1997.7

Isoform-dependent activation of adenylyl cyclase by proteolysis

T Ebina, Y Toya, N Oka, J Kawabe, C Schwencke, Y Ishikawa

FEBS LETTERS   401 ( 2-3 )   223 - 226   1997.1

AC-ALPHA, AN ENDOGENOUS INHIBITOR OF CARDIAC ADENYLYL-CYCLASE

JI KAWABE, T EBINA, CJ HOMCY, Y ISHIKAWA

CIRCULATION   92 ( 8 )   2731 - 2731   1995.10

DESENSITIZATION OF ADENYLYLCYCLASE BY PHOSPHORYLATION

G IWAMI, J KAWABE, T EBINA, S ISMAIL, PJ CANNON, CJ HOMCY, Y ISHIKAWA

CIRCULATION   90 ( 4 )   413 - 413   1994.10

DIFFERENTIAL ACTIVATION OF ADENYLYL-CYCLASE BY PROTEIN-KINASE-C ISOENZYMES (VOL 269, PG 16554, 1994)

JI KAWABE, G IWAMI, T EBINA, S OHNO, T KATADA, Y UEDA, CJ HOMCY, Y ISHIKAWA

JOURNAL OF BIOLOGICAL CHEMISTRY   269 ( 36 )   22912 - 22912   1994.9

PROTEIN-KINASE-C REGULATES ADENYLYLCYCLASE CATALYTIC ACTIVITY IN AN ISOENZYME-SPECIFIC MANNER

J KAWABE, G IWAMI, T EBINA, S ISMAIL, CJ HOMCY, Y ISHIKAWA

FASEB JOURNAL   8 ( 7 )   A1388 - A1388   1994.4

INVIVO GENERATION OF AN ADENYLYLCYCLASE ISOFORM WITH A HALF-MOLECULE MOTIF

S KATSUSHIKA, J KAWABE, CJ HOMCY, Y ISHIKAWA

JOURNAL OF BIOLOGICAL CHEMISTRY   268 ( 4 )   2273 - 2276   1993.2

Role of endothelium in biphasic hypoxic response of the isolated pulmonary artery in the rat

OGAWA Y., KAWABE JUN-ICHI, ONODERA SOKICHI, TOBISE KATSUYUKI, MORITA KAZUTOYO, HARADA TAKAYUKI, HIRAYAMA TOMOYA, TAKEDA AKINORI

Jpn. Circ. J.   58   228 - 236   1993

CHARACTERIZATION OF NOVEL MEMBERS OF CARDIAC ADENYLYL CYCLASE FAMILY - MESSENGER-RNA LEVELS PARALLEL THE DEVELOPMENT OF HEART-FAILURE

Y ISHIKAWA, S KATSUSHIKA, J KAWABE, DE VATNER

CIRCULATION   86 ( 4 )   767 - 767   1992.10

Nerve Growth Factor Induces Maturation of Vasa Vasorum Neovasculature in Injured Vascular walls

Akira Asanome, Junichi Kawabe, Motoki Matsuki, Atsushi Yamauchi, Naofumi Takehara, Motoi Okada, Naoyuki Hasebe

日本循環器学会 

Enhanced Inhibition of Neointimal Hyperplasia by Overexpression of Apurinic/apyrimidinic Endonuclease (APE1) in Endothelial Progenitor Cells International conference

Atsushi Yamauchi, Jun-ichi Kawabe, Maki Kabara, Akira Asanome,Motoki Matsuki, Naoki Nakagawa, Naofumi Takehara, Naoyuki Hasebe

日本血管生物学会 

Peripheral Nerve is critical for Vasa Vasorum Maturation in Injured Vascular Walls. -Effects of SubstanceP on Pericytes-

Akira Asanome, Junichi Kawabe, Maki Kabara, Motoki Matsuki, Atsushi Yamauchi, Naoki Nakagawa, Hisanobu Ohta, Naofumi akehara, Naoyuki Hasebe

日本血管生物学会 

内皮前駆細胞（EPC）を介したプロスタサイクリンの下肢虚血改善作用　－血管周細胞分化による血管新生効果－

浅野目　晃、川辺　淳一、山内　敦司、竹原　有史、長谷部　直幸

日本脈管学会　総会 

The cardioprotective effect of prostaglandin E2/EP4 system is important for the late phase preconditioning International conference

T Kanno, J Kawabe, Yuhki, N Takehara, F Ushikubi, N Hasebe

AHA （アメリカ心臓病学会) 

Prostacylcin augments endotherial progenitor cell functions and rescue peripheral ischemia

M Okada, J Kawabe, Y Aburakawa, T Kanno, A　Yamauchi, N Nakagawa, N Tashiro, MYamaki, F　Ushikubi and N Hasebe

日本循環器学会 

Prostacyclin System in Endothelial Progenitor Cells is crucial for Regulation of Vascular Remodeling through their recruitment to injured vascular walls.

Yamauchi A, Kawabe J, Kobayashi M, Kannno T, Ushikubi F, Hasebe N, P

日本循環器学会 

Prostacyclin relieves peripheral ischemia through enhancement of critical functions of endothelial progenitor cells International conference

M Okada, J Kawabe, Y Aburakawa, T Kanno, A　Yamauchi, N Nakagawa, N Tashiro, MYamaki, F　Ushikubi and N Hasebe

AHA （アメリカ心臓病学会） 

Impaired functional endothelial progenitor cells inhibited growth of Prostacycline signaling as a target for cancer therapy -. International conference

Sasaki T, Okumura S, Shibukawa K, Osanai S, Kawabe J, Ohsaki Y

AACR(アメリカ癌研究学会)  

Role of Autocrine Prostacyclin System in Crucial Functions of Endothelial Progenitor Cells.

Kawabe J, Kanno T, Tashiro N, Okada M, Yuhki K, Ushikubi F, Hasebe N

日本循環器学会 

Decreased Susceptibility to Release of TGF-β1 from Platelet and Microalbuminuria inTXA2 Receptor Deficient Mice with Diabetes Mellitus

Fujino T, Suzuki Y, Kawabe J, Yuhki K, Fukuzawa J, Matsuki M, Nakagawa, N Hasebe N, Ushikubi F

日本循環器学会 

Deletion of prostacyclin-receptor in bone marrow attenuates differentiation of endothelial progenitor cells, and Enhances Vascular Intimal Hyperplasia Circulation. International conference

Kawabe J, Yuhki K, Kannno T, Hasebe N, Ushikubi F

AHA （アメリカ心臓病学会） 

Decreased susceptibility to endothelial dysfunction and glomerular remodeling in diabetes mellitus in thromboxane A2 receptor deficient mice.

Fujino T, Suzuki Y, Ｋawabe J, Nakagawa N, Yuhki K, Hasebe N, Kikuchi K, Ushikubi F

日本高血圧学会 

内皮前駆細胞分化とプロスタノイド－再生医療への応用にむけて－　

川辺淳一

第２回　名寄・士別循環器研究会　 

Decreased Susceptibility to Glomerular Regeneration in Thromboxane A2 Receptor Deficient Mice　

Fujino T, Abe K, Nakagawa N, Yuhki K, Kawabe J, Hasebe N, Kikuchi K, Ukikubi F

日本循環器学会 

Deletion of PGI2-receptor (IP) in Bone Marrow Enhances Progenitor Cells-Mediated Vascular Intimal Hyperplasia

Kawabe J, Kanno T, Yuhki K, Hasebe N, Kikuchi K, Usikubi F

日本循環器学会 

Decreased Susceptibility to Glomerular Hypertrophy and Albuminuria in Thromboxane A2 Receptor Deficient Mice.

Fujino T, Abe K, Nakagawa N, Yuhki K, Kawabe J, et al

ISHR　（国際高血圧学会） 

Thermal treatment attenuates vascular atherosclerosis and lowers blood pressure in spontaneously hypertensive rats. International conference

Tashiro N, Okada M, Izawa K, Aizawa Y, Kawabe J, et al

ISHR　（国際高血圧学会） 

Combination of Pitavastatin and Thermal Treatment Attenuates Cytokine-induced Monocye/macrophage Activation and Oxidative Stress. International conference

Okada M, Hasebe N, Tashiro N, Yamauchi A, Kawabe J Kikuchi K

ISHR　（国際高血圧学会） 

Repeated Thermal Treatment Reduces Adventitial Inflammatory Response in Arteriosclerosis. International conference

Okada M, Hasebe N, Tashiro N, Yamauchi A, Kawabe J Kikuchi K

ISHR　（国際高血圧学会） 

血管新生内膜形成におけるプロスタノイドの役割

川辺淳一

第８回 旭川血管リモデリング研究会  

炎症性頻脈の発生機序：プロスタノイドによる心機能調節　

川辺淳一

第2回 宮崎サイエンスキャンプ　　　 

PE-520/ Combination of pitavastatin and therminal treatment attenuates angiotensin Ⅱ-induced cellular activation and oxidative stress.

Okada M, Tashiro N, Izawa K, Kawabe J, Hasebe N, Kikuchi K

日本循環器学会 

炎症性頻脈の発生機序

川辺淳一

第７回 旭川血管リモデリング研究会　 

心血管系におけるプロスタノイドの役割

川辺淳一

第23回 病態生理研究会  

Paradoxical suppression of angiotensin II-induced vascular remodeling in impaired glutathione redox system.

Izawa K, Hasebe N, Okada M, Sumitomo K, Kawabe J, et al

日本循環器学会 

Impaired glutathione redox regulation paradoxically suppresses angiotensin Ⅱ-induced vascular remodeling International conference

Izawa K, Hasebe N, Okada M, Kawabe J, et al

AHA（アメリカ心臓病学会 

β-adrenergic and muscarinic regulation of the heart requires type 5 adenylyl cyclase.

Okumura S, Kawabe J, et al　

日本循環器学会 

The type 5 adenylyl cyclase mediates Ca2+-mediated regulation of Ca2+ channels in the heart.

Kawabe J, Ishikawa Y, et al　

日本循環器学会 

Disruption of the type 5 adenylyl cyclase gene preserve cardiac function against pressure overload.

Okumura S, Kawabe J, et al

日本循環器学会 

Caveolin modulates microtubule polymerization in vascular smooth muscle cells.

Kawabe J, Ishikawa Y, et al

日本循環器学会 

Translocation of caveolin regulates stretch- induced ERK activity in vascular smooth muscle cells.　　

Kawabe J, Ishikawa Y, et al

日本循環器学会 

毛細血管幹細胞の組織内維持システムの証明

2017.7 - 2020.3

萌芽研究

Vascular niche for maintenance of capillary stem cells

Grant number：17K19368  2017.6 - 2020.3

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Research (Exploratory)

Kawabe Jun-ichi

新規因子による血管成熟機構の解明と、動脈硬化に対する治療法の開発

2017.4 - 2020.3

基盤研究(B)

Ninj1-mediated vascular maturation and development of therapeutic strategy for atherosclerosis

Grant number：17H04170  2017.4 - 2020.3

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

Kawabe Jun-ichi

毛細血管幹細胞（CapSCs)の再生医療における新規細胞ソースとしての開発

2016.4

第一三共株式会社　三菱UFJキャピタル 

人工血管を利用した血管新生制御機構の解析

2016.4

東京大学