Tranilast alleviates visceral hypersensitivity and colonic hyperpermeability by suppressing NLRP3 inflammasome activation in irritable bowel syndrome rat models Reviewed

T. Nozu, H. Arie, S. Miyagishi, M. Ishioh, K. Takakusaki, T. Okumura

International Immunopharmacology   133   112099   2024.4

Imeglimin prevents visceral hypersensitivity and colonic hyperpermeability in irritable bowel syndrome rat model Reviewed

Tsukasa Nozu, Saori Miyagishi, Masatomo Ishioh, Kaoru Takakusaki, Toshikatsu Okumura

Journal of Pharmacological Sciences   153 ( 1 )   26 - 30   2023.9

Phlorizin attenuates postoperative gastric ileus in rats Reviewed

Tsukasa Nozu, Saori Miyagishi, Masatomo Ishioh, Kaoru Takakusaki, Toshikatsu Okumura

Neurogastroenterology & Motility   2023.8

Brain neuropeptides, neuroinflammation and irritable bowel syndrome Invited Reviewed

Masatomo Ishioh, Tsukasa Nozu, Toshikatsu Okumura

Digestion   2023.7

Ghrelin prevents lethality in a rat endotoxemic model through central effects on the vagal pathway and adenosine A2B signaling : Brain ghrelin and anti-septic action Reviewed

Sho Igarashi, Tsukasa Nozu, Masatomo Ishioh, Takuya Funayama, Chihiro Sumi, Takeshi Saito, Yasumichi Toki, Mayumi Hatayama, Masayo Yamamoto, Motohiro Shindo, Hiroki Tanabe, Toshikatsu Okumura

Journal of Physiology and Biochemistry   2023.4

Centrally administered GLP-1 analogue improves intestinal barrier function through the brain orexin and the vagal pathway in rats Reviewed

Takuya Funayama, Tsukasa Nozu, Masatomo Ishioh, Sho Igarashi, Chihiro Sumi, Takeshi Saito, Yasumichi Toki, Mayumi Hatayama, Masayo Yamamoto, Motohiro Shindo, Hiroki Tanabe, Toshikatsu Okumura

Brain Research   1809   148371   2023.4

Prostaglandin I2 suppresses the development of gut-brain axis disorder in irritable bowel syndrome in rats Reviewed

Shima Kumei, Masatomo Ishioh, Tsukasa Nozu, Toshikatsu Okumura

Biochimica et Biophysica Acta (BBA) - General Subjects   1867 ( 5 )   130344   2023.3

A Case of Adult-onset Periodic Fever, Aphthous Stomatitis, Pharyngitis and Cervical Adenitis Syndrome Responsive to Colchicine Reviewed

Tsukasa Nozu, Masumi Ohhira, Masatomo Ishioh, Toshikatsu Okumura

Internal Medicine   2023

Activation of basal forebrain cholinergic neurons improves colonic hyperpermeability through the vagus nerve and adenosine A2B receptors in rats Reviewed

Masatomo Ishioh, Tsukasa Nozu, Saori Miyagishi, Sho Igarashi, Takuya Funayama, Masumi Ohhira, Toshikatsu Okumura

Biochemical Pharmacology   206   115331   2022.10

Oxytocin acts centrally in the brain to improve leaky gut through the vagus nerve and a cannabinoid signaling in rats Reviewed

Toshikatsu Okumura, Tsukasa Nozu, Masatomo Ishioh, Sho Igarashi, Takuya Funayama, Shima Kumei, Masumi Ohhira

Physiol Behav .   2022.7

A patient with familial Mediterranean fever mimicking diarrhea-dominant irritable bowel syndrome who successfully responded to treatment with colchicine: a case report Reviewed

Shima Kumei, Masatomo Ishioh, Yuki Murakami, Katsuyoshi Ando, Tsukasa Nozu, Toshikatsu Okumura

Journal of Medical Case Reports   16   2022.6

Pathophysiological Commonality Between Irritable Bowel Syndrome and Metabolic Syndrome: Role of Corticotropin-releasing Factor-Toll-like Receptor 4-Proinflammatory Cytokine Signaling Reviewed

Tsukasa Nozu, Toshikatsu Okumura

J Neurogastroenterol Motil   28 ( 2 )   173 - 184   2022.4

Peripheral apelin mediates visceral hypersensitivity and impaired gut barrier in a rat irritable bowel syndrome model Reviewed

Tsukasa Nozu, Saori Miyagishi, Masatomo Ishioh, Kaoru Takakusaki, Toshikatsu Okumura

Neuropeptides   94   102248   2022.4

Activation of central adenosine A2B receptors mediate brain ghrelin-induced improvement of intestinal barrier function through the vagus nerve in rats Reviewed

Masatomo Ishioh, Tsukasa Nozu, Sho Igarashi, Hiroki Tanabe, Shima Kumei, Masumi Ohhira, Kaoru Takakusaki, Toshikatsu Okumura

Experimental Neurology   2021.7

EMA401, an angiotensin II type 2 receptor antagonist blocks visceral hypersensitivity and colonic hyperpermeability in rat model of irritable bowel syndrome Reviewed

Tsukasa Nozu, Saori Miyagishi, Rintaro Nozu, Masatomo Ishioh, Kaoru Takakusaki, Toshikatsu Okumura

Journal of Pharmacological Sciences   146 ( 3 )   121 - 124   2021.7

Phlorizin attenuates visceral hypersensitivity and colonic hyperpermeability in a rat model of irritable bowel syndrome Reviewed

Tsukasa Nozu, Saori Miyagishi, Masatomo Ishioh, Kaoru Takakusaki, Toshikatsu Okumura

Biomedicine & Pharmacotherapy   139   2021.5

Centrally administered butyrate improves gut barrier function, visceral sensation and septic lethality in rats Reviewed

Toshikatsu Okumura, Tsukasa Nozu, Masatomo Ishioh, Sho Igarashi, Shima Kumei, Masumi Ohhira

Journal of Pharmacological Sciences   146 ( 2021 )   183 - 191   2021.4

Central regulatory mechanisms of visceral sensation in response to colonic distension with special reference to brain orexin Reviewed

Okumura T., Ishioh M., Nozu T.

Neuropeptides   2021.2

Centrally administered orexin prevents lipopolysaccharide and colchicine induced lethality via the vagal cholinergic pathway in a sepsis model in rats Reviewed

Sho Igarashi, Tsukasa Nozu, Masatomo Ishioh, Shima Kumei, Takeshi Saito, Yasumichi Toki, Mayumi Hatayama, Masayo Yamamoto, Motohiro Shindo, Hiroki Tanabe, Toshikatsu Okumura

Biochemical Pharmacology   182   2020.10

Imipramine improves visceral sensation and gut barrier in rat models of irritable bowel syndrome Reviewed

Tsukasa Nozu, Saori Miyagishi, Masatomo Ishioh, Kaoru Takakusaki, Toshikatsu Okumura

European Journal of Pharmacology   2020.9

Losartan improves visceral sensation and gut barrier in a rat model of irritable bowel syndrome. Reviewed

Tsukasa Nozu, Saori Miyagishi, Rintaro Nozu, Kaoru Takakusaki, Toshikatsu Okumura

Neurogastroenterology and Motility   32 ( 6 )   2020.6

Ghrelin Acts in the Brain to Block Colonic Hyperpermeability in Response to Lipopolysaccharide Through the Vagus Nerve Reviewed

Ishioh, M., Nozu, T., Igarashi, S., Tanabe, H., Kumei, S., Ohhira, M., Okumura, T.

Neuropharmacology   173   108116   2020.5

Adenosine A1 receptor agonist induces visceral antinociception via 5-HT1A, 5-HT2A, dopamine D1 or cannabinoid CB1 receptors, and the opioid system in the central nervous system Reviewed

Okumura, T. Nozu, T. Ishioh, M. Igarashi, S. Kumei, S. Ohhira, M.

Physiology & behavior   2020.3

Brain orexin improves intestinal barrier function via the vagal cholinergic pathway. Reviewed

Okumura T., Nozu T., Ishioh M., Igarashi S., Kumei S., Ohhira M.

Neuroscience Letters   2020.1

5-HT2A receptors but not cannabinoid receptors in the central nervous system mediate levodopa-induced visceral antinociception in conscious rats Reviewed

Toshikatsu Okumura, Tsukasa Nozu

Naunyn-Schmiedeberg's Archives of Pharmacology   2020

Butyrate inhibits visceral allodynia and colonic hyperpermeability in rat models of irritable bowel syndrome Reviewed

Tsukasa Nozu, Saori Miyagishi, Rintaro Nozu, Kaoru Takakusaki, Toshikatsu Okumura

Scientific Reports   2019.12

Metformin inhibits visceral allodynia and increased gut permeability induced by stress in rats Reviewed

Tsukasa Nozu, Saori Miyagishi, Rintaro Nozu, Toshikatsu Okumura, Kaoru Takakusaki

Journal of Gastroenterology and Hepatology   34 ( 1 )   186 - 193   2019.1

Dehydroepiandrosterone sulfate improves visceral sensation and gut barrier in a rat model of irritable bowel syndrome Reviewed

Tsukasa Nozu, Saori Miyagishi, Rintaro Nozu, Kaoru Takakusaki, Toshikatsu Okumura

European Journal of Pharmacology   852   198 - 206   2019

Grape seed extract inhibits visceral allodynia and increased colonic permeability induced by repeated water avoidance stress in rats Reviewed

Hideyuki Arie, Tsukasa Nozu, Saori Miyagishi, Masayuki Ida, Takayuki Izumo, Hiroshi Shibata

Nutrients   2019

[Mechanism of visceral hypersensitivity in patients with irritable bowel syndrome].

Tsukasa Nozu, Toshikatsu Okumura

Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology   116 ( 7 )   552 - 559   2019

Central oxytocin signaling mediates the central orexin-induced visceral antinociception through the opioid system in conscious rats Reviewed

Okumra T., Nozu T., Kumei S., Ohhira M.

Physiology & behavior   198   96 - 101   2018.10

Role of the cannabinoid signaling in the brain orexin- and ghrelin-induced visceral antinociception in conscious rats Reviewed

Toshikatsu Okumura, Tsukasa Nozu

Journal of Pharmacological Sciences   2018.5

Ghrelin acts centrally to induce an antinociceptive action during colonic distension through the orexinergic, dopaminergic and opioid systems in conscious rats Reviewed

Okumura, T., Nozu, T., Kumei, S., Takakusaki, K., Ohhira, M.

Brain research   2018.2

A glucagon-like peptide-1 analog, liraglutide improves visceral sensation and gut permeability in rats Reviewed

Tsukasa Nozu, Saori Miyagishi, Shima Kumei, Rintaro Nozu, Kaoru Takakusaki, Toshikatsu Okumura

Journal of Gastroenterology and Hepatology   33 ( 1 )   232 - 239   2018.1

Altered colonic sensory and barrier functions by CRF: roles of TLR4 and IL-1 Reviewed

Tsukasa Nozu, Saori Miyagishi, Rintaro Nozu, Kaoru Takakusaki, Toshikatsu Okumura

Journal of endocrinology   239 ( 2 )   241 - 252   2018

Pioglitazone improves visceral sensation and colonic permeability in a rat model of irritable bowel syndrome Reviewed

Tsukasa Nozu, Saori Miyagishi, Rintaro Nozu, Kaoru Takakusaki, Toshikatsu Okumura

Journal of Pharmacological Sciences   139 ( 2019 )   46 - 49   2018

Central oxytocin signaling mediates the central orexin-induced visceral antinociception through the opioid system in conscious rats. Reviewed

Toshikatsu Okumura, Tsukasa Nozu, Shima Kumei, Masumi Ohhira

Physiology and Behavior   2018

Repeated water avoidance stress induces visceral hypersensitivity; role of IL-1, IL-6 and peripheral corticotropin-releasing factor Reviewed

Nozu, T., Miyagishi, S., Nozu, R., Takakusaki, K., Okumura, T.

J Gastroenterol Hepatol   32 ( 12 )   1958 - 1965   2017.12

Lovastatin inhibits visceral allodynia and increased colonic permeability induced by lipopolysaccharide or repeated water avoidance stress in rats Reviewed

Tsukasa Nozu, Saori Myagishi, Shima Kumei, Rintaro Nozu, Kaoru Takakusaki, Toshikatsu Okumura

European Journal of Pharmacology   818   228 - 234   2017.10

Cold Exposure Related Fever with an Mediterranean Fever (MEFV) Gene Mutation.

Shima Kumei, Tsukasa Nozu, Masumi Ohira, Saori Miyagishi, Toshikatsu Okumura

Internal medicine (Tokyo, Japan)   56 ( 16 )   2233 - 2236   2017.8

Lipopolysaccharide induces visceral hypersensitivity: role of interleukin-1, interleukin-6, and peripheral corticotropin-releasing factor in rats. Reviewed

Nozu T., Miyagishi S., Nozu R., Takakusaki K., Okumura T.

Journal of Gstroenterology   52 ( 1 )   72 - 80   2017.1

Cold Exposure Related Fever with an MEFV Gene Mutation Reviewed

Shima Kumei, Tsukasa Nozu, Masumi Ohira, Saori Miyagishi, Toshikatsu Okumura

Internal Medicine   2017

Brainstem control of locomotion and muscle tone with special reference to the role of the mesopontine tegmentum and medullary reticulospinal systems. Reviewed

K. Takakusaki, R. Chiba, T. Nozu, T. Okumura

Journal of Neuralal Transmission   123 ( 7 )   695 - 729   2016.7

[Diagnosis at a Glance.].

Tsukasa Nozu, Shima Kumel, Masumi Ohhira, Toshikatsu Okumura

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine   105 ( 5 )   911 - 913   2016.5

Water avoidance stress induces visceral hyposensitivity through peripheral corticotropin releasing factor receptor type 2 and central dopamine D2 receptor in rats. Reviewed

T. NOZU, S. MIYAGISHI, R. NOZU, K. TAKAKUSAKI, T. OKUMURA

Neurogastroenterology and Motility   28 ( 4 )   522 - 531   2016.4

Adenosine A1 receptors mediate the intracisternal injection of orexin-induced antinociceptive action against colonic distension in conscious rats. Reviewed

Okumura T., Nozu T., Kumei S., Takakusaki K., Miyagishi S., Ohhira M.

Journal of the Neurological Sciences   362   106 - 110   2016.3

Levodopa acts centrally to induce an antinociceptive action against colonic distension through activation of D2 dopamine receptors and the orexinergic system in the brain in conscious rats. Reviewed

Okumura T., Nozu T., Kumei S., Takakusaki K., Miyagishi S., Ohhira M.

Journal of Pharmacological Science   130 ( 2 )   123 - 127   2016.2

Bullous pemphigoid and percutaneous endoscopic gastrostomy Reviewed

Tsukasa Nozu, Toshikatsu Okumura

Geriatrics and Gerontology International   16 ( 10 )   1173 - 1174   2016

Retropharyngeal Calcific Tendinitis Reviewed

Tsukasa Nozu, Shima Kumei, Masumi Ohhira, Toshikatsu Okumura

Internal Medicine   54   2277 - 2277   2015.9

Antinociceptive action against colonic distension by brain orexin in conscious rats. Reviewed

Okumura T., Nozu T., Kumei S., Takakusaki K., Miyagishi S., Ohhira M.

Brain Research   1598   12 - 17   2015.2

Corticotropin-releasing factor receptor type 1 and type 2 interaction in irritable bowel syndrome Reviewed

Tsukasa Nozu, Toshikatsu Okumura

Journal of Gastroenterology   50 ( 9 )   819 - 830   2015

Colorectal distention induces acute and delayed visceral hypersensitivity: role of peripheral corticotropin-releasing factor and interleukin-1 in rats Reviewed

Tsukasa Nozu, Shima Kumei, Saori Miyagishi, Kaoru Takakusaki, Toshikatsu Okumura

Journal of Gastroenterology   2015

Screening for Major Depressive Disorder with the Patient Health Questionnaire (PHQ-9 and PHQ-2) in an Outpatient Clinic Staffed by Primary Care Physicians in Japan: A Case Control Study. Reviewed

Keiko Suzuki, Shima Kumei, Masumi Ohhira, Tsukasa Nozu, Toshikatsu Okumura

PLoS One   10 ( 3 )   e0119147   2015

Involvement of the dopaminergic system in the central orexin-induced antinociceptive action against colonic distension in conscious rats Reviewed

T. Okumura, T. Nozu, S. Kumei, K. Takakusaki, S. Miyagishi, M. Ohhira

Neuroscience Letters   605   34 - 38   2015

Water-avoidance stress enhances gastric contractions in freely moving conscious rats: role of peripheral CRF receptors Reviewed

Tsukasa Nozu, Shima Kumei, Kaoru Takakusaki, Toshikatsu Okumura

Journal of Gastroenterology   49 ( 5 )   799 - 805   2014

A balance theory of peripheral corticotropin-releasing factor receptor type 1 and type 2 signaling to induce colonic contractions and visceral hyperalgesia in rats Reviewed

Tsukasa Nozu, Kaoru Takakusaki, Toshikatsu Okumura

Endocrinology   155 ( 12 )   4655 - 4664   2014

An adult patient with cyclic vomiting syndrome successfully treated with oral sumatriptan. Reviewed

Toshikatsu Okumura, Masumi Ohhira, Shima Kumei, Tsukasa Nozu

American Journal of Gastroenterology   109 ( 2 )   292 - 293   2014

Urocortin 2 blocks the suppression of gastric antral contractions induced by lipopolysaccharide in freely moving conscious rats Reviewed

Tsukasa Nozu, Kaoru Takakusaki, Toshikatsu Okumura

Regulatory Peptides   190-191   12 - 17   2014

Peripheral corticotropin-releasing factor (CRF) induces stimulation of gastric contractions in freely moving conscious rats: role of CRF receptor types 1 and 2 Reviewed

T.Nozu, Y.Tsuchiya, S.Kumei, K.Takakusaki, T.Okumura

Neurogastroenterology and Motility   25   190 - 197   2013.1

A higher frequency of lumbar OPLL in erderly in an outpatient clinic in Japan Reviewed

Okumura T., Ohhira, Kumei S., Nozu T.

International Journal of General Medicine   6   729 - 732   2013

Inhibition of corticotropin releasing factor (CRF) receptor type 2 signaling enhances peripheral CRF-induced stimulation of colonic contractions in conscious rats Reviewed

Tsukasa Nozu, Toshikatsu Okumura

Gastroenterology   144 ( Suppl 1 )   S-712   2013

Peritoneal loose body. Reviewed

T. Nozu, T. Okumura

Intern Med.   51   2057 - 2057   2012.8

Clinical features of the patients with functional dyspepsia visiting primary care physician Invited

T. Nozu

55 ( 1 )   1 - 6   2012.7

The rate of polymyalgia rheumatica (PMR) and remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome in a clinic where primary care physicians are working in Japan. International journal

Toshikatsu Okumura, Satoshi Tanno, Masumi Ohhira, Tsukasa Nozu

Rheumatology international   32 ( 6 )   1695 - 9   2012.6

Endogenous orexin-A in the brain mediates 2-deoxy-D-glucose-induced stimulation of gastric motility in freely moving conscious rats. Reviewed

T. Nozu, Y. Tsuchiya, S. Kumei, K. Takakusaki, K. Ataka, M. Fujimiya, T. Okumura

J Gastroenterol.   47 ( 4 )   404 - 411   2012.4

Chronic right lower abdominal pain due to lumbar ossification of the posterior longitudinal ligament (OPLL). Reviewed

T. Okumura, K. Ebisawa, M. Ohhira, T. Nozu, Y. Tsuchiya, M. Inoue, M. Tanaka

Am J Gastroenterol.   107 ( 1 )   142 - 143   2012.1

The rate of polymyalgia rgheumatica (PMR) and remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome in a clinic where primari care physicians are working in Japan Reviewed

T. Okumura, S. Tanno, M. Ohhira, T. Nozu

Rheumatol Int.   32 ( 6 )   1695 - 1699   2012

IL-1 Receptor Antagonist Blocks the Lipopolysaccharide-Induced Inhibition of Gastric Motility in Freely Moving Conscious Rats. Reviewed

Y. Tsuchiya, T. Nozu, S. Kumei, M. Ohhira, T. Okumura

Dig Dis Sci   57 ( 10 )   2555 - 2561   2012

Epiploic appendagitis as an uncommon cause of lower abdominal pain. Reviewed

T. Okumura, M. Ohhira, Y. Tsuchiya, Y. Kikuchi, Y. Kohogo, S. Yoshihara, H. Okabe, T. Nozu

Open J Gastroenterol.   2   31 - 33   2012

High rate of smoking in female patients with Mondor's disease in an outpatient clinic in Japan. International journal

Toshikatsu Okumura, Masumi Ohhira, Tsukasa Nozu

International journal of general medicine   5   735 - 8   2012

Modulatory effects of the GABAergic basal ganglia neurons on the PPN and the muscle tone inhibitory system in cats. Reviewed

K. Takakusaki, K. Obara, T. Nozu, T. Okumura

Arch Ital Biol.   149 ( 4 )   385 - 405   2011.12

Central orexin-A increases colonic motility in conscious rats. Reviewed

T. Nozu, S. Kumei, K. Takakusaki, K. Ataka, M. Fujimiya, T. Okumura

Neurosci Lett.   498 ( 2 )   143 - 146   2011.8

Visceral sensation and irritable bowel syndrome; with special reference to comparison with functional abdominal pain syndrome. Invited

T. Nozu, T. Okumura

J Gastroenterol Hepatol.   26   122 - 127   2011

Role of brain orexin in the pathophysiology of functional gastrointestinal disorders. Invited

T. Okumura, T. Nozu

J Gastroenterol Hepatol.   26   61 - 66   2011

Severe hyponatremia in association with I 131 therapy in patient with metastatic thyroid cancer. Reviewed

T. Nozu, Y. Yoshida, M. Ohhira, T. Okumura

Intern Med.   50 ( 19 )   2169 - 2174   2011

Bullous pemphigoid and percutaneous endoscopic gastrostomy Reviewed

T. Nozu, H. Mita

Intern Med.   49   971 - 975   2010.4

Acquired factor V inhibitor in a patient with a mechanical aortic valve under warfarinization Reviewed

T. Nozu, H. Mita, T. Okumura

Intern Med   49 ( 20 )   2229 - 2233   2010.4

Characteristics in patients with headache in an outpatient clinic in Japan Reviewed

T. Okumura, S. Tanno, M. Ohhira, T. Nozu

Asia Pac Fam Med.   9   10   2010

Idiopathic spontaneous intramural hematoma of the colon: a case report and review of the literature Reviewed

T. Nozu

Clin. J. Gatroenterol.   2 ( 3 )   161 - 165   2009.4

Altered rectal sensory response induced by balloon distention in patients with functional abdominal pain syndrome Reviewed

T. Nozu, M. Kudaira

Biopsychosoc. Med   3   13 - 13   2009.4

Clinical characteristics of asymptomatic esophagitis Reviewed

T. Nozu, H. Komiyama

J Gastroenterol   43   27 - 31   2008.4

Pneumatosis cystoides intestinalis Reviewed

T. Nozu

Intern Med   47   325 - 325   2008.4

Emphysematous cystitis with air bubbles in the inferior vena cava Reviewed

T. Nozu

Int. J. Urology   15   947 - 947   2008.4

Corticotropin-releasing factor induces rectal hypersensitivity after repetitive rectal painful distention in healthy humans Reviewed

T. Nozu, M. Kudaira

J. Gastroenterol.   41   740 - 744   2006.4

Repetitive rectal painful distention induces rectal hypersensitivity in patients with irritable bowel syndrome. Reviewed

T. Nozu, M. Kudaira, S. Kitamori, A. Uehara

J. Gastroenterol   41   217 - 222   2006.4

消化管機能異常症とは？

野津 司

診断と治療   93 ( 3 )   348 - 353   2005.4

The diagnoses and outcome of patients complaining of fever without any abnormal findings on diagnostic tests Reviewed

T. Nozu, A. Uehara

Intern. Med   44   901 - 902   2005.4

Peripheral injection of sauvagine prevents repeated colorectal distension-induced visceral pain in female rats Reviewed

M. Million, C. Maillo, D.A. Adelson, T. Nozu, A. Gauthier, J Rivier, G.P. Chrousos, A. Bayati, H. Mattsson, Y. Taché

Peptides   26   1188 - 1195   2005.4

Fitz-Hugh-Curtis syndrome. Reviewed

T. Nozu, H. Komiyama

Intern. Med.   45   1645 - 1645   2005.4

毎朝胃がもたれ，胸焼けがすると訴える患者が来たら

野津 司

診断と治療   93 ( 3 )   348 - 353   2005.4

Isolated dissection of the superior mesenteric artery. Reviewed

T. Nozu, H. Komiyama, T. Okumura

Gastroenterol   127   1029 - 1282   2004.4

Inadequate health care-seeking behavior of Japanese patients with functional gastrointestinal disorders: a preliminary survey. Reviewed

T. Nozu, M. Kudaira, S. Kitamori, A. Uehara

J. Gastroenterol.   37   231 - 232   2002

Peripheral urocortin delays gastric emptying: role of CRF receptor 2. Reviewed

T. Nozu, V. Martinez, J. Rivier, Y. Tache

Am J Physiol   276   G867 - G874   1999

Malignant intestinal schwannoma: a case report and a review of the literature in Japan. Reviewed

T. Nozu, A. Takahashi, H. Asakawa, A. Uehara, Y. Kohgo, T. Suzuki

Intern. Med.   34   1101 - 1105   1995

Effects of ranitidine on gastric vesicles containing H, K-adenosine triphosphatase in rats. Reviewed

K. Kubo, A. Uehara, T. Kubota, T. Nozu, M. Moriya, Y. Watanabe, E. Shoji, S.B. Santos, K. Harada, Y. Kohgo

Scand.J. Gastroenterol.   30   944 - 951   1995

Undifferentiated carcinoma in the cardioesophageal junction which produces parathyroid hormone related protein. Reviewed

T. Nozu, A. Takahashi, A. Uehara, Y. Kohgo, T. Suzuki

Intern. Med.   34   695 - 699   1995

EFFECTS OF RUNNING TRAINING ON INVITRO BROWN ADIPOSE-TISSUE THERMOGENESIS IN RATS

T NOZU, K KIKUCHI, K OGAWA, A KUROSHIMA

INTERNATIONAL JOURNAL OF BIOMETEOROLOGY   36 ( 2 )   88 - 92   1992.5

Non-thermal stress-induced modifications of fatty acids profiles in rat brown adipose tissue. Reviewed

T. Ohno, K. Ogawa, H. Ohinata, T. Nozu, A. Kuroshima

J.Therm.Biol.   17   251 - 256   1992

Effects of running training on in vitro brown adipose tissue thermogenesis in rats. Reviewed

T. Nozu, K. Kikuchi, K. Ogawa, A. Kuroshima

Int.J. Biometeorol.   36   88 - 92   1992

Effect of immobilization stress on in vitro and in vivo thermogenesis of brown adipose tissue. Reviewed

T. Nozu, S. Okano, K. Kikuchi, T. Yahata, A. Kuroshima

Jpn.J.Physiol.   42   299 - 308   1992

In vitro thermogenesis of brown adipose tissue in fasted rats. Reviewed

K. Kikuchi, S. Okano, T. Nozu, T. Yahata, A. Kuroshima

Jpn.J.Physiol.   42   165 - 170   1992

イミプラミンはIBSモデルの内臓知覚過敏・腸管透過性亢進を抑制する International conference

野津 司, 石王 応知, 奥村 利勝

神経消化器病学会 

アンジオテンシンII受容体拮抗薬はIBSモデルの内臓知覚過敏・腸管透過性亢進を抑制する International conference

野津 司, 石王 応知, 奥村 利勝

神経消化器病学会 

ストレスによる内臓知覚，腸管透過性の変化-末梢corticotropin-releasing factorの役割と過敏性腸症候群

野津 司, 奥村 利勝

消化器病学会週間 

ストレスによる内臓知覚，腸管透過性の変化-末梢corticotropin-releasing factorの役割と過敏性腸症候群

野津 司, 奥村 利勝

DDW Japan 2019  日本消化器病学会

腹膜垂炎と腹腔内遊離体

奥村利勝

第123回日本消化器病学会北海道支部例会【地方】  日本消化器病学会北海道支部

水疱性類天疱瘡と経皮内視鏡的胃瘻造設術

奥村利勝

第117回日本消化器内視鏡学会北海道支部例会【地方】  日本消化器内視鏡学会北海道支部

STRESS, CRF AND GUT International conference

Tsukasa Nozu

Summer School on Stress  Stress Education

ワークショップ15「過敏性腸症候群のすべて」glucagon-like peptide-1アナログ，リラグルチドの内臓知覚と腸管透過性に対する効果について

野津 司, 奥村 利勝

第14回日本消化管学会総会学術集会  日本消化管学会

過敏性腸症候群におけるcorticotropin-releasing factorの役割

野津 司, 奥村 利勝

G+ The 3rd meeting  ゼリア新薬工業

シンポジウム2 大腸機能性疾患の病態，診断治療の現状と展望ーストレス，CRF，過敏性腸症候群

野津 司, 奥村 利勝

第72回日本大腸肛門病学会学術集会  日本大腸肛門病学会

過敏性腸症候群とcorticotropin-releasing factor

野津 司, 奥村 利勝

消化器病学会北海道支部地方会  日本消化器病学会

Repeated water avoidance stress induces visceral hypersensitivity; role of IL-1, IL-6 and peripheral corticotropin-releasing factor International conference

Tsukasa Nozu, Toshikatsu Okumura

5th Biennial Congress of the Asian Neurogastroenterology & Motility Association 

消化管運動と内臓知覚における末梢CRF受容体サブタイプの役割－balance theoryについて

野津 司, 奥村 利勝

日本神経消化器病学会 

末梢corticotropin-releasing factorと胃運動－functional dyspepsiaとの関連について

野津 司, 奥村 利勝

第44回日本潰瘍学会 

消化管運動と内臓知覚における末梢CRF受容体サブタイプの役割－balance theoryについて

野津 司, 奥村 利勝

日本神経消化器病学会 

Peripheral corticotropin-releasing factor (CRF) induces stimulation of colonic contractions and visceral hyperalgesia in rats; role of CRF receptor type 1 and 2

Digestive Disease Week Japan 

末梢CRFと胃運動－FDの病態生理との関連について

野津 司, 奥村利勝

日本消化器病学会週間  日本消化器病学会

Inhibition of corticotropin releasing factor (CRF) receptor type 2 signaling enhances peripheral CRF-induced stimulation of colonic contractions in conscious rats International conference

Tsukasa Nozu, Tozhikatsu Okumura

米国消化器病学会  AGA

オレキシンと消化管運動

野津 司, 奥村利勝

消化器学会週間  日本消化器病学会

Visceral sensation and irritable bowel syndrome; with special reference to comparison with functional abdominal pain syndrome International conference

野津 司

Asian Pacific Topic Conference 

シンポジウム 無症候性逆流性食道炎患者の臨床的検討

野津 司

第49回日本消化器病学会大会 

Repeated rectal distention induces visceral hypersensitivity in irritable bowel syndrome patients; possible contribution of corticotrophin-releasing factor International conference

野津 司

Digestive Disease Week and Annual Meeting of American Gastroenterological Association. 

Asian Pacific Topic Conference Young Investigator Award

2010.11   Asian Pacific Topic Conference  

野津 司

Japan Gut Club奨励賞

2010.10   Japan Gut Club  

野津 司

第20回日本消化器病学会奨励賞受賞

2007.4   日本消化器病学会  

野津 司

日本内科専門医会研究奨励賞

2000.4   日本内科専門医会  

野津 司, 大滝純司, 首藤龍人, 久保光司

過敏性腸症候群実験動物モデルにおける食品素材有効性の検証

2017.10 - 2018.12

サントリーウエルネス株式会社 

過敏性腸症候群の病態におけるCRF-LPS-サイトカイン経路の役割

2017.4 - 2018.3

民間財団等 

Understanding the adaptive brain function in relation to the alteration of posture-locomotor synergies

Grant number：26120004  2014.7 - 2019.3

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Takakusaki Kaoru, Obara Kazuhiro, Nakajima Toshi, Takahashi Mirai, Miyagishi Saori, Nozu Tsukasa, Okumura Toshikatsu, Matsumoto seiji, Funakoshi Hiroshi

Role of brain orexin in the pathogenesis of irritable bowel syndrome

Grant number：26460955  2014.4 - 2018.3

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

Toshikatsu Okumura

LPS，炎症性サイトカインと末梢CRF受容体サブタイプの消化管機能における相関

2014.4 - 2018.3

基盤研究(C)

Mechanisms of postural control operated by the basal ganglia, brainstem and spinal cord

Grant number：25290001  2013.4 - 2018.3

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

Takakusaki Kaoru, OKUMURA Toshikatsu, NOZU Tsukasa, OBARA Kazuhiro, FUNAKOSHI Hiroshi, KOBAYASHI Kazuto

神経ペプチドオレキシンの消化管運動調節機構とその意義

2011.4 - 2014.3

基盤研究(C)

Relationship between sleep-awake cycle and gastrointestinal motility

Grant number：23659391  2011.4 - 2013.3

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Exploratory Research

OHHIRA Masumi, NOZU Tsukasa, OKUMURA Toshikatsu, TAKAKUSAKI Kaoru

ＰＰＡＲγｌｉｇａｎｄによる膵癌に対する抗腫瘍効果ー血管新生関連分子発現の解析ー

2010.4 - 2013.3

基盤研究(C)

秋山記念生命科学振興財団研究助成一般

秋山記念生命科学振興財団 

JGC研究奨励助成論文 奨励賞

Japan Gut Club 

JGC研究奨励助成論文 奨励賞

Japan Gut Club 

柏葉meeting

2023.7

高校生による医療体験活動報告会、地域医療討論会

2023.3

札幌西高等学校探究授業

2023.1

第24回日本神経消化器病学会市民公開講座

2022.9

高校生メディカル講座（釧路湖陵）

2022.9

メディカルキャンプセミナー

2022.8

柏葉meeting

2022.7

第2回道東三域メディカル交流会

2022.3

高校生による医療体験活動報告会、地域医療討論会

2022.3

令和3年度高校生メディカル講座（釧路湖陵高校）

2021.9

柏葉meeting

2021.7

第１回道東三域メディカル交流会

2021.3

高校生による医療体験活動報告会、地域医療討論会

2021.3

旭川龍谷高校派遣講座

2019.9

高校生による医療体験活動発表会

2019.3

高校生による医療体験活動発表会

2018.3

足寄中学校3学年キャリア授業

2017.11

足寄中学校PTA連合大会

2017.11

高校生による医療体験活動発表会

2017.3

高校生による医療体験活動発表会

2016.3

高校生による医療体験活動発表会

2015.3

高校生による医療体験活動発表会

2014.3

派遣講座 高校生メディカル講座（釧路湖陵高等学校）

2013.12

派遣講座 高校生メディカル講座（帯広柏葉高等学校）

2013.11

派遣講座 高校生メディカル講座（北見北斗高等学校）

2013.9

高校メディカルキャンプ

2013.8

第3回高校生による地域医療討論会

2013.3

十勝診療協議会ー旭川医大が目指す地域医療講演

2013.3

派遣講座 「地域医療の現状－旭川医大が目指す地域医療－」 （帯広市）

2012.11

あさひかわオープンカレッジ

2012.9

第2回高校生による地域医療討論会

2012.3

派遣講座：地域医療の現状－旭川医大が目指す地域医療－

2011.9

派遣講座：医師という仕事－これまでの歩みを振り返って－

2011.9

メディカルキャンプセミナー 旭川医大が目指す地域医療

2011.8 - 2011.9

日本内科学会認定医専門医試験症例要約査読委員

2002.4