Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1038/labinvest.2014.121

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DOI： 10.1016/j.bbrc.2013.11.070

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Other Link： http://orcid.org/0000-0002-1708-0348

Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1679/aohc.74.41

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Other Link： https://www.jstage.jst.go.jp/article/aohc/74/1/74_41/_article

DOI： 10.1369/0022155412448791

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Authorship：Lead author   Language：Japanese   Publishing type：Research paper (scientific journal)  

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.neures.2011.09.008

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Publisher：10  

DOI： 10.1007/s00535-011-0438-2

PubMed

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Language：English   Publishing type：Research paper (scientific journal)  

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Publisher：2  

DOI： 10.1016/j.crohns.2009.09.006

PubMed

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DOI： 10.1679/aohc.70.79

PubMed

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DOI： 10.1679/aohc.68.337

PubMed

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Language：Japanese   Publisher：(一社)日本解剖学会  

J-GLOBAL

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Language：Japanese  

J-GLOBAL

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Language：Japanese   Publisher：(一社)日本解剖学会  

J-GLOBAL

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Language：Japanese   Publisher：(一社)日本解剖学会  

J-GLOBAL

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Language：English   Publishing type：Research paper, summary (international conference)   Publisher：LIPPINCOTT WILLIAMS & WILKINS  

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Language：Japanese   Publisher：(一社)日本解剖学会  

J-GLOBAL

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Language：Japanese   Publisher：(一社)日本解剖学会  

J-GLOBAL

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Language：Japanese   Publisher：(一社)日本解剖学会  

J-GLOBAL

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Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

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Language：English   Publishing type：Research paper, summary (international conference)   Publisher：AMER SOC CELL BIOLOGY  

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Language：Japanese   Publisher：(一社)日本解剖学会  

J-GLOBAL

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Language：English   Publisher：INT SOC HISTOLOGY & CYTOLOGY  

Secretogranin III (SgIII), a member of the granin protein family, is expressed specifically in neuronal and endocrine cells. To examine the precise localization of SgIII in the endocrine pancreas, pancreatic tissues of rats were analyzed immunocytochemically with a polyclonal antiserum raised against rat SgIII. By light microscopy of semithin sections, the immunoreactivity for SgIII was readily detected in pancreatic A- and B-cells, faintly so in D- cells, and not at all in the exocrine pancreas. By immunoelectron microscopy, immunogold particles indicative of SgIII were observed in the peripheral regions of secretory granules, and universally in the pancreatic endocrine cells. Morphometrical analyses indicated that SgIII is most preferentially localized in the periphery of the secretory granule among granins. These findings suggest that SgIII is closely associated with the secretory granule membrane, serving to anchor the aggregates of other soluble constituents to the membrane.

DOI： 10.1679/aohc.67.57

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Language：English   Publisher：INT SOC HISTOLOGY & CYTOLOGY  

Secretogranin III (SgIII), a member of the granin protein family, is expressed specifically in neuronal and endocrine cells. To examine the precise localization of SgIII in the endocrine pancreas, pancreatic tissues of rats were analyzed immunocytochemically with a polyclonal antiserum raised against rat SgIII. By light microscopy of semithin sections, the immunoreactivity for SgIII was readily detected in pancreatic A- and B-cells, faintly so in D- cells, and not at all in the exocrine pancreas. By immunoelectron microscopy, immunogold particles indicative of SgIII were observed in the peripheral regions of secretory granules, and universally in the pancreatic endocrine cells. Morphometrical analyses indicated that SgIII is most preferentially localized in the periphery of the secretory granule among granins. These findings suggest that SgIII is closely associated with the secretory granule membrane, serving to anchor the aggregates of other soluble constituents to the membrane.

DOI： 10.1679/aohc.67.57

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Language：English   Publisher：HISTOCHEMICAL SOC INC  

Secretogranin III (SgIII) is one of the acidic secretory proteins, designated as granins, which are specifically expressed in neuronal and endocrine cells. To clarify its precise distribution in the anterior lobe of the rat pituitary gland, we raised a polyclonal antiserum against rat SgIII for immunocytochemical analyses. By immunohistochemistry using semithin sections, positive signals for SgIII were detected intensely in mammotropes and thyrotropes, moderately in gonadotropes and corticotropes, but not in somatotropes. The distribution pattern of SgIII in the pituitary gland was similar to that of chromogranin B (CgB), also of the granin protein family, suggesting that the expressions of these two granins are regulated by common mechanisms. The localization of SgIII in endocrine cells was confirmed by immunoelectron microscopy. In particular, secretory granules of mammotropes and thyrotropes were densely and preferentially co-labeled for SgIII and CgB in their periphery. Moreover, positive signals for SgIII were occasionally found in cells containing both prolactin and TSH in secretory granules. These lines of evidence suggest that SgIII and CgB are closely associated with the secretory granule membrane and that this membrane association might contribute to gathering and anchoring of other soluble constituents to the secretory granule membrane.

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Language：English   Publisher：HISTOCHEMICAL SOC INC  

Secretogranin III (SgIII) is one of the acidic secretory proteins, designated as granins, which are specifically expressed in neuronal and endocrine cells. To clarify its precise distribution in the anterior lobe of the rat pituitary gland, we raised a polyclonal antiserum against rat SgIII for immunocytochemical analyses. By immunohistochemistry using semithin sections, positive signals for SgIII were detected intensely in mammotropes and thyrotropes, moderately in gonadotropes and corticotropes, but not in somatotropes. The distribution pattern of SgIII in the pituitary gland was similar to that of chromogranin B (CgB), also of the granin protein family, suggesting that the expressions of these two granins are regulated by common mechanisms. The localization of SgIII in endocrine cells was confirmed by immunoelectron microscopy. In particular, secretory granules of mammotropes and thyrotropes were densely and preferentially co-labeled for SgIII and CgB in their periphery. Moreover, positive signals for SgIII were occasionally found in cells containing both prolactin and TSH in secretory granules. These lines of evidence suggest that SgIII and CgB are closely associated with the secretory granule membrane and that this membrane association might contribute to gathering and anchoring of other soluble constituents to the secretory granule membrane.

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Language：English   Publisher：INT SOC HISTOLOGY & CYTOLOGY  

The development of GH cells and the pituitary-adrenal axis was morphologically examined in male Djungarian hamsters (Phodopus singorus) exposed to short days and those kept under long days and receiving daily afternoon injections of melatonin, from the time of weaning (20 days) until 100 days of age. The postnatal increase in area of ACTH cells under long days was inhibited in short-day-exposed or melatonin-treated animals. It was suggested that a short photoperiod may suppress, via melatonin, the development of ACTH cells. GH cells were not affected by age, photoperiod or exogenous melatonin, Under long days, the zona fasciculata decreased in volume with age, while the zona reticularis increased. Such changes in the volumes of these adrenocortical zones were depressed under short days. In addition, the volumes of the zona fasciculata and zona reticularis in long-day-housed animals became respectively larger and smaller subsequent to orchidectomy and melatonin administration, These results suggest that fasciculata cells in deeper levels become progressively differentiated into reticularis cells, that short photoperiod inhibits development of both zonae, and that such an inhibition is caused mainly by the decreased secretion of androgens.

DOI： 10.1679/aohc.64.211

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Language：English   Publisher：INT SOC HISTOLOGY & CYTOLOGY  

The development of GH cells and the pituitary-adrenal axis was morphologically examined in male Djungarian hamsters (Phodopus singorus) exposed to short days and those kept under long days and receiving daily afternoon injections of melatonin, from the time of weaning (20 days) until 100 days of age. The postnatal increase in area of ACTH cells under long days was inhibited in short-day-exposed or melatonin-treated animals. It was suggested that a short photoperiod may suppress, via melatonin, the development of ACTH cells. GH cells were not affected by age, photoperiod or exogenous melatonin, Under long days, the zona fasciculata decreased in volume with age, while the zona reticularis increased. Such changes in the volumes of these adrenocortical zones were depressed under short days. In addition, the volumes of the zona fasciculata and zona reticularis in long-day-housed animals became respectively larger and smaller subsequent to orchidectomy and melatonin administration, These results suggest that fasciculata cells in deeper levels become progressively differentiated into reticularis cells, that short photoperiod inhibits development of both zonae, and that such an inhibition is caused mainly by the decreased secretion of androgens.

DOI： 10.1679/aohc.64.211

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Language：English   Publisher：WILEY-BLACKWELL  

Light and electron microscopic immunocytochemical observations were made to demonstrate central pinealopetal fibers immunoreactive for gamma -aminobutyric acid (GABA) and synapses between their terminals and pinealocytes in the pineal gland of four rodent (Wistar-King rat; mouse; Syrian hamster, Mesocricetus auratus; Hartley strain guinea pig) and one nonrodent (tree shrew, Tupaia glis) species. GABA-immunoreactive myelinated and unmyelinated fibers and endings were found in the parenchyma of the pineal gland of all the animals examined. In the rodent species, GABAergic fibers were mainly found in the intermediate and proximal portions of the pineal gland and were nearly or entirely absent in the distal portion of the gland. Abundant GABAergic fibers were evenly distributed throughout the gland of the tree shrew. In all the animals, the habenular and posterior commissures contained abundant GABA-positive fibers, and some of them were followed to the pineal gland. GABA-positive endings made synaptic contact with pinealocytes, occasionally in mice and guinea pigs, and frequently in tree shrews; no synapses were observed in Syrian hamsters and rats. In the pineal gland of all the animals, GABA-immunoreactive cell bodies were not detected, and sympathetic fibers were not immunoreactive for GABA. These data indicate that GABAergic fibers are main pinealopetal projections from the brain. Ln view of the difference in the distribution of these fibers, central GABAergic innervation may play a more significant role in nonrodents than in rodents. The frequent occurrence of GABAergic synapses on pinealocytes in the tree shrew suggests that GABA released at these synapses directly controls activity of pinealocytes of this animal. J. Comp. Neurol. 430:72-84, 2001. (C) 2001 Wiley-Liss, Inc.

DOI： 10.1002/1096-9861(20010129)430:1<72::AID-CNE1015>3.0.CO;2-T

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Language：English   Publisher：ELSEVIER SCIENCE BV  

Conventional and immunocytochemical, light- and electron-microscopic studies on the innervation of the pineal gland of the tree shrew (Tupaia glis) were made. Neuropeptide Y (NPY)-immunoreactive fibers, which were abundantly distributed in the gland, disappeared almost completely after superior cervical ganglionectomy, suggesting that these fibers are mostly postganglionic sympathetic fibers. By contrast, tyrosine hydroxylase (TH)-immunoreactive fibers, which were less numerous than NPY-fibers, remained in considerable numbers in ganglionectomized animals, indicating the innervation of TH-positive fibers from extrasympathetic sources. Bundles of substance P (SP)- or calcitonin gene-related peptide (CGRP)-immunoreactive fibers, entering the gland at its distal end, were left intact after ganglionectomy. SP-fibers were numerous, but CGRP-fibers were scarce in the gland. SP-immunoreactive fibers were myelinated and nonmyelinated, and were regarded as peripheral fibers because of the presence of a Schwann cell sheath. NPY- and SP-immunoreactive fibers and endings were mainly localized in the pineal parenchyma. NPY-immunoreactive endings synapsed frequently, and SP-positive ones did less frequently, with the cell bodies of pinealocytes. The results suggest that NPY and SP directly control the activity of pinealocytes. Sections stained for myelin showed that thick and less thick bundles of myelinated fibers entered the gland by way of the habenular and posterior commissures, respectively. Under the electron microscope, the bundles were found to contain also unmyelinated fibers. A considerable number of nerve endings synapsing with the cell bodies of pinealocytes remained in ganglionectomized animals; these endings were not immunoreactive for TH or SP. Such synaptic endings may be the terminals of commissural fibers. (C) 1999 Published by Elsevier Science B.V. All rights reserved.

DOI： 10.1016/S0006-8993(99)01856-9

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Language：English   Publisher：WILEY-LISS  

The distribution and density of tyrosine hydroxylase (TH) and neuropeptide Y (NPY)-immunoreactive, sympathetic fibers and calcitonin gene-related peptide (CGRP)-, substance P (SP)-, and vasoactive intestinal polypeptide (VIP)-immunoreactive, non-sympathetic fibers in the pineal gland, the effects of superior cervical ganglionectomy (SCGX) on these fibers, and the location of their terminals in the pineal gland were compared between rodents and non-rodents. A dense network of TH/NPY-positive fibers is present all over the pineal gland. A less dense network of CGRP/SP- or VIP-positive fibers occurs in the whole pineal gland of non-rodents, but these fibers are usually confined to the superficial pineal gland in rodents. After SCGX, some TH/NPY-fibers remain only in the deep pineal gland in rodents, whereas considerable numbers of these fibers persist throughout the gland in non-rodents. Thus, the remaining fibers, probably originating from the brain, may be more numerous in non-rodents. Since CGRP-, SP- or VIP-immunoreactive fibers in the pineal capsule can be traced to those in the gland, and since these fibers are ensheathed by Schwann cells, it is concluded that these fibers belong to the peripheral nervous system. However, the existence of SP-positive central fibers cannot be denied in some species. In the superficial pineal gland of rodents, sympathetic terminals are mostly localized in perivascular spaces, whereas the parenchymal innervation by sympathetic fibers in the pineal gland is more dense in non-rodents than in rodents. Synapses between sympathetic nerve terminals and pinealocytes occur occasionally in non-rodents, but only rarely in the superficial pineal gland of rodents. The occurrence of the synapses may depend on the frequency of intraparenchymal sympathetic terminals. (C) 1999 Wiley-Liss, Inc.

DOI： 10.1002/(SICI)1097-0029(19990815/01)46:4/5<265::AID-JEMT4>3.3.CO;2-J

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Language：English   Publisher：WILEY-LISS  

Background The previous results regarding regional and day-night differences in pinealocyte size in rats are conflicting, The relationships between these differences and the vascularity and sympathetic innervation have scarcely been investigated,
Methods: Wistar-King rats, kept under light/dark 12:12, were killed at midday or midnight in October, The nuclear density of pinealocytes in the superficial pineal was measured on the dorsoperipheral, dorsocentral, ventroperipheral, and ventrocentral regions at distal, middle, and proximal levels at daytime and nighttime, The total area of blood vessels per unit area at daytime and nighttime and total length of tyrosine hydroxylase (TH)-immunoreactive fibers per unit area at daytime were determined on the same regions at the same levels,
Results: Pinealocyte size was larger toward the distal levels and in the periphery than in the center at any level, The area of blood vessels and length of TH fibers were also larger toward the distal levels; the former in the ventral region and the latter in the dorsal and ventral regions were larger in the periphery than in the center, Ventral pinealocytes, but not dorsal ones, showed day-night changes in size, Prominent day-night rhythms in area of blood vessels occurred in the ventral region, where TH fibers were more abundant than in the dorsal region,
Conclusions: Pinealocyte size shows the distal to proximal and peripheral to central gradients, which may be related to the differential distribution of blood vessels and sympathetic fibers, Since pinealocytes and blood vessels, showing prominent day-night changes in size, are localized in the more richly innervated regions, sympathetic fibers may play an important role in controlling these rhythms. (C) 1998 Wiley-Liss, Inc.

DOI： 10.1002/(SICI)1097-0185(199801)250:1<80::AID-AR8>3.0.CO;2-I

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Language：English   Publisher：MUNKSGAARD INT PUBL LTD  

Light microscopic, electron microscopic and immunohistochemical observations of the various portions of the pineal gland of the cotton rat (Sigmodon hispidus) were made. The volume of the proximal half occupied about 30% of the whole organ, and pinealocytes were slightly smaller in size in the proximal portion than elsewhere, The distal and intermediate portions contained few interstitial cells and numerous astrocytes, but the proximal portion lacked interstitial cells and had more abundant astrocytes than elsewhere. Astrocytes, which were immunoreactive for glial fibrillary acidic protein, mainly lined the pericapillary spaces in the distal and intermediate portions, but in the proximal portion these cells often surrounded isolated or groups of pinealocytes. In the distal and intermediate portions, abundant sympathetic fibers and less numerous non-sympathetic, peptidergic fibers were mainly localized in the pericapillary spaces; these fibers were sparsely distributed in the parenchyma close to interstitial cells or astrocytes. In the proximal portion, non-sympathetic fibers were scarce and sympathetic fibers were distributed abundantly and almost exclusively in the parenchyma. Most of the sympathetic fibers were adjacent to astrocytes and, occasionally, made specialized contact with them. Fenestrae in the capillary endothelium were numerous in the distal portion but absent in the proximal portion. Thus, marked differences in structure existed between the distal and proximal portions of the pineal gland of the cotton rat, suggesting that both portions are functionally dissimilar. In addition, the present study indicates that the proximal portion of the cotton rat was well developed and showed morphological features similar to the deeply situated pineal glands of other mammals.

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Language：English   Publisher：CHAPMAN HALL LTD  

We have examined the effects of chronic sympathetic denervation on non-sympathetic myelinated and unmyelinated fibres in the superficial pineal gland of the Chinese hamster (Cricetulus griseus), using LM, EM and immunohistochemistry. The results suggest that non-sympathetic, myelinated and unmyelinated fibres enter the superficial pineal gland at its distal portion by way of the nervi conarii, and that these fibres are immunoreactive for calcitonin gene-related peptide or substance P. Non-sympathetic, myelinated and unmyelinated fibres in the superficial pineal gland increased in number following chronic superior cervical ganglionectomy. The number of unmyelinated fibres in the nervi conarii also increased in ganglionectomized animals. Thus, the numerical increase of calcitonin gene-related peptide or substance P fibres found in the superficial pineal gland after long-term sympathectomy may be due to sprouting of these fibres. It is speculated that the growth of non-sympathetic, myelinated and unmyelinated fibres and myelination of the former fibres occurring after sympathectomy are caused by nerve growth factor-related mechanisms.

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Language：English   Publisher：INT SOC HISTOLOGY & CYTOLOGY  

Immunohistochemistry revealed the presence of tyrosine hydroxylase (TH)-, neuropeptide Y (NPY)-, calcitonin gene-related peptide (CGRP)- and substance P (SP)-immunoreactive nerve fibers and SP-immunoreactive neuronal cell bodies in the pineal gland of the cotton rat (Sigmodon hispidus). Abundant TH- and NPY-immunoreactive fibers were distributed evenly throughout the gland; less numerous CGRP- and SP-immunoreactive fibers were distributed in the superficial pineal and the stalk, but were scarce in the deep pineal. All the immunoreactive fibers were usually found around blood vessels. Since TH- and NPY-immunoreactive fibers in various pineal regions disappeared completely with superior cervical ganglionectomy, these fibers are all considered postganglionic sympathetic fibers. Intrapineal CGRP- or SP-immunoreactive fibers decreased considerably in number following superior cervical ganglionectomy, suggesting that some sympathetic fibers contain CGRP or SP. Bilateral bundles of nerve fibers under the transverse sinuses, corresponding to the nervi conarii, contained TH-, NPY-, CGRP- and SP-immunoreactive fibers, which continued into those distributed in the pineal capsule. In the nervi conarii, fibers immunoreactive for TH and NPY disappeared after superior cervical ganglionectomy, but those immunoreactive for CGRP and SP persisted. Thus, non-sympathetic, CGRP- and SP-immunoreactive fibers, together with sympathetic fibers, are presumed to enter the gland by way of the nervi conarii. Neuronal cell bodies, containing SP-like immunoreactivity and being possibly parasympathetic in nature, occurred occasionally in the superficial pineal.

DOI： 10.1679/aohc.57.47

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Language：English   Publisher：MUNKSGAARD INT PUBL LTD  

Light microscopic observations on the superficial pineal gland of Wistar-King rats were made to examine whether or not pineal volume and pinealocyte size, expressed as nuclear density, at daytime or nighttime are affected by long-term exposure to 50 Hz rotating magnetic field (MF) at 5.0 muT. Determinations of pineal volume and pinealocyte size were repeated twice (April and October) during the year. Size of pinealocytes in MF-exposed and sham-exposed rats exhibited, in addition to the difference between peripheral and central regions, regional differences in a proximodistal direction; pinealocytes in the distal and middle-peripheral regions were usually larger than those in the proximal and middle-central regions at daytime or nighttime. In October, distal and proximal pinealocytes showed significant day-night changes in size in sham-exposed rats, but not in MF-exposed animals. The situations in the two groups were almost reversed in April. Significant day-night differences were scarcely found in pinealocyte size in the middle region in the two groups. Throughout the study, pineal volume and pinealocyte size in each region were generally the same between MF-exposed and sham-exposed rats at daytime or nighttime. The results suggest that pinealocytes in the distal and proximal regions, but not those in the middle region, are affected by MF-exposure; day-night differences in sizes of distal and proximal pinealocytes appear in April and disappear in October under the influence of MF. MF may exert an effect on mechanisms controlling day-night rhythms of pinealocyte size in the rat.

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Language：English   Publisher：INT SOC HISTOLOGY & CYTOLOGY  

Intrapineal neurons and intracapsular and intrapineal myelinated fibers were studied by light microscopy in male cotton rats (Sigmodon hispidus) at various postnatal ages. Until 300 days of age, neurons are encountered mainly in the distal third of the organ; neuronal nuclei are largest in this region. The remaining regions contain only a few neurons with smaller nuclei. In all regions, nuclear sizes of the neurons increase, and neuronal numbers reduce by half until 100-200 days. Neurons thus consist of different populations of cells, and the aging changes in neuronal nuclei seem to be related to the differentiation of the organ. The disappearance of neurons and the enlargement of the nuclei of remaining neurons proceed simultaneously with age. Intracapsular and intrapineal myelinated fibers appear at 20 days and their density increases with age. As the myelinated fibers are distributed mainly in the distal region and its capsule, these fibers are related topographically to intrapineal neurons. The intracapsular myelinated fibers continue into bilateral bundles of myelinated fibers found under the transverse sinuses, corresponding to the nervi conarii. Since the intracapsular fibers and the fibers traced between the capsule and the parenchyma bifurcate in a proximal direction, the intracapsular fibers are considered to run proximally, some entering the organ.

DOI： 10.1679/aohc.54.379

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Language：English   Publisher：WILEY-LISS  

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Language：English   Publisher：SPRINGER  

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Language：English   Publisher：MUNKSGAARD INT PUBL LTD  

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Event date： 2013.12

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：旭川市  

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Event date： 2013.9

Language：English   Presentation type：Poster presentation  

Venue：新潟市  

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Event date： 2013.8

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：花巻市  

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Event date： 2012.12

Language：English   Presentation type：Poster presentation  

Venue：San Fransisco  

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Event date： 2012.9

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：大阪  

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Event date： 2011.12

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：札幌  

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Event date： 2011.11

Language：English   Presentation type：Poster presentation  

Venue：Orlando, Florida  

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Event date： 2011.9

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：北海道  

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Event date： 2010.11

Language：English   Presentation type：Poster presentation  

Venue：Chicago  

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Event date： 2010.3

Language：English   Presentation type：Poster presentation  

Venue：盛岡  

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Event date： 2010.3

Language：Japanese   Presentation type：Poster presentation  

Venue：盛岡  

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Event date： 2009.9

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：仙台  

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Event date： 2009.9

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：仙台  

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Event date： 2009.3

Language：Japanese   Presentation type：Poster presentation  

Venue：岡山  

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Event date： 2008.9

Language：English   Presentation type：Oral presentation (general)  

Venue：Tokyo、Japan  

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Event date： 2008.3

Language：Japanese   Presentation type：Poster presentation  

Venue：大分  

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Event date： 2008.3

Language：Japanese   Presentation type：Poster presentation  

Venue：大分  

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Event date： 2007.3

Language：Japanese   Presentation type：Poster presentation  

Venue：大阪  

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Event date： 2007.3

Language：Japanese   Presentation type：Poster presentation  

Venue：大阪  

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Event date： 2006.3

Language：Japanese   Presentation type：Poster presentation  

Venue：相模原  

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Event date： 2005.3

Language：Japanese   Presentation type：Poster presentation  

Venue：富山  

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Event date： 2005.3

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

Venue：富山  

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Event date： 2005.3

Language：Japanese   Presentation type：Poster presentation  

Venue：富山  

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Event date： 2004.8

Language：English   Presentation type：Poster presentation  

Venue：Kyoto, Japan  

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スーパーサイエンスハイスクール指定校である旭川西高等学校の事業に参画し、高校生に対して旭川医科大学における電子顕微鏡観察実習を実施した。

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旭川永嶺高等学校にて細胞学・組織学の講義を実施した。

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スーパーサイエンスハイスクール指定校である旭川西高等学校の事業に参画し、高校生に対して旭川医科大学における電子顕微鏡観察実習を実施した。

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No.3で実施した実験実習の発表会を通して、細胞および組織のかたちの見方を指導

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高校生に対する実験実習（免疫染色法と電子顕微鏡観察）の実施と、内容のまとめおよび発表会の指導

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電子顕微鏡観察についてのワークショップを実施

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電子顕微鏡観察についてのワークショップの実施

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細胞、組織形態について講義を行う。

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細胞、組織学についての講義を実施

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全国から主として高等学校の教員の受講者を募り、旭川医科大学で行われている最先端研究技術の実験実習を行ってもらい、各教育活動への活用を図ってもらう。

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カムイ大雪サイエンスパートナー（旭川ウェルビーイングコンソーシアム）が主宰するサイエンスイベント「わくわくサイエンス」に参加。旭川市民を対象として細胞の電子顕微鏡写真を紹介するコーナーを担当した。

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スーパーサイエンスハイスクール指定校である旭川西高等学校の事業に参画し、高校生に対して電子顕微鏡観察についてのワークショップと旭川医科大学における電子顕微鏡観察実習を実施した。

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電子顕微鏡観察についてのワークショップ、旭川医科大学における電子顕微鏡観察実習、実習内容についての発表会 平成27年10月23日（金）、平成27年11月30日(月)

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旭川南高等学校と連携し高校生に対して細胞についての事前講義、電子顕微鏡観察についてのワークショップ、旭川医科大学において電子顕微鏡観察実習と免疫染色実習、高等学校において実験についての発表会を実施した。

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細胞生物学についての講演を実施 平成27年7月28日（火）

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全国から中高の教員を公募し、先端生命科学研究についての講義と実習を合宿形式で実施（平成27年８月3日〜6日）し、その成果をテレビ会議システムを用いて遠隔カンファレンスで発表させた（平成28年1月29日）.

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平成27年2月5日（木）北海道旭川西高等学校 高校生を対象に生命科学の講義を行う。旭川市

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平成26年6月26日(木) 北海道旭川東栄高等学校 高校生を対象に生命科学の講義とワークショップを行う。 旭川市

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全国から中高の教員を公募し、先端生命科学研究についての講義と実習を合宿形式で実施（平成26年８月４日〜７日）し、その成果をテレビ会議システムを用いて遠隔カンファレンスで発表させた（平成27年1月21日）.

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顕微鏡でみる生命のかたち 平成25年12月18日(水) 13:00～15:30 旭川市 北海道旭川東栄高校 視聴覚教室

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顕微鏡でみる生命のかたち 平成25年11月26日(火) 13:00～15:00 旭川市 北海道旭川東栄高校 視聴覚教室

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教育研究推進センターとの共同実施
平成25年9月11日13：00-
帝京高校理数コース２年生
医学部施設見学及び実習

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顕微鏡でみる生命のかたち 平成25年9月26日(木) 11:55～12:45 旭川市 旭川南高等学校

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平成25年8月8日（月）旭川市（藤田観光ワシントンホテル）

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全体統括副責任者兼実施主担当者、連携コーディネート、電子顕微鏡観察実験担当 平成25年8月5日（月）～平成25年8月8日（木） 旭川市（旭川医科大学、藤田観光ワシントンホテル）

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顕微鏡でみる生命のかたち 平成25年6月17日(月) 13:00～15:30 旭川市 旭川東栄高等学校

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顕微鏡でみる生命のかたち 平成25年6月18日(火) 13:00～14:30 旭川市 旭川東栄高等学校

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「顕微鏡でみる生命のかたち」（旭川市）H24.10.10

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「顕微鏡でみる生命のかたち」（旭川市）H24.9.25

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「顕微鏡でみる生命のかたち」（旭川市）H24.9.27

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「顕微鏡でみる生命のかたち」（旭川市）H24.8.23

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「細胞と組織」（旭川市）H24.7.17

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中期目標に掲げられている「教育面での社会貢献を推進する」に鑑み、高大連携の一環として市内の２校と連携して高校生実験体験講座を実施し、高校生に対して生命科学の講義実習を通して、生命科学研究の啓蒙、生命倫理の醸成および医療系への進学、就職を促すキャリア教育を実施する。

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講演

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大会実行委員長

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大会実行委員

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