Updated on 2025/01/20

写真a

 
NAGAOKA Taiji
 
Organization
School of Medicine Medical Course Clinical Medicine Ophthalmology
Contact information
メールアドレス
Homepage
http://www.asahikawa-med.ac.jp/dept/mc/ophtha/

Degree

  • 医学博士 ( 2000.3   旭川医科大学 )

Research Interests

  • 循環生理

  • Retinal Circulation

  • DIabetic Retinopathy

  • Ophthalmology

Research Areas

  • Life Science / Ophthalmology

Education

  • Asahikawa Medical College   Graduate School, Division of Medicine

    - 2000.3

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    Country： Japan

  • Asahikawa Medical College   Faculty of Medicine

    - 1994.3

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    Country： Japan

Research History

  • Asahikawa Medical College   Associate Professor

    2013.7

  • Asahikawa Medical College   Lecturer

    2007.4 - 2013.6

  • Asahikawa Medical College   Assistant Professor

    2001.4 - 2005.3

Professional Memberships

  • 日本眼科学会

    1994.5

Studying abroad experiences

  • 2005.4 - 2007.3   Texas A&M University Scott & White Eye Institute  

Papers

  • Effects of Habitual Cigarette Smoking on Retinal Circulation in Patients With Type 2 Diabetes Reviewed

    Omae T, Nagaoka T, Yoshida A.

    Investigative Ophthalmology & Visual Science   57 ( 3 )   1345 - 1351   2016.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1167/iovs.15-18813

  • Neuroprotective effect of water-dispersible hesperetin in retinal ischemia reperfusion injury Reviewed

    Shimouchi A, Yokota H, Ono S, Matsumoto C, Tamai T, Takumi H, Narayanan SP, Kimura S, Kobayashi H, Caldwell RB, Nagaoka T, Yoshida A

    Japanese Journal of Ophthalmology   60 ( 1 )   51 - 61   2016.1

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Role of Glial Cells in Regulating Retinal Blood Flow During Flicker-Induced Hyperemia in Cats Reviewed

    Song YS, Nagaoka T, Yoshioka T, Nakabayashi S, Tani T, Yoshida A

    Investigative Ophthalmology & Visual Science   56 ( 12 )   7551 - 7559   2015.12

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

  • Choroidal thickness evaluation before and after hemodialysis in patients with and without diabetes Reviewed

    Ishibazawa A, Nagaoka T, Minami Y, Kitahara M, Yamashita T, Yoshida A.

    Invest Ophthalmol Vis Sci   56 ( 11 )   6534 - 6541   2015.11

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    Language：English   Publishing type：Research paper (scientific journal)  

  • En-face optical coherence tomography angiography of neovascularization elsewhere in hemicentral retinal vein occlusion Reviewed

    Sogawa K, Nagaoka T, Ishibazawa A, Takahashi A, Tani T, Yoshida A

    Int Med Case Rep J   8   263 - 266   2015.10

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Anteroposterior Tortuosity of the Retinal Vein at Arteriovenous Crossings in Healthy Subjects Reviewed

    Sogawa K, Nagaoka T, Tani T, Yoshida A

    Current Eye Research   40 ( 10 )   1040 - 1045   2015.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3109/02713683.2014.971930.

  • Effect of intravitreal Rho kinase inhibitor ripasudil (K-115) on feline retinal microcirculation Reviewed

    Nakabayashi S, Kawai M, Yoshioka T, Song YS, Tani T, Yoshida A, Nagaoka T

    Experimental Eye Research   139 ( 10 )   132 - 135   2015.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.exer.2015.07.008

  • Imaging of the Corneal Sub-Basal Whorl-Like Nerve Plexus: More Accurate Depiction of the Extent of Corneal Nerve Damage in Patients with Diabetes Reviewed

    Utsunomiya T, Nagaoka T, Hanada K, Omae T, Yokota H, Abiko A, Haneda M, Yoshida A

    Investigative Ophthalmology & Visual Science   56 ( 9 )   5417 - 5423   2015.8

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  • Relationship Between Retinal Blood Flow and Serum Adiponectin Concentrations in Patients With Type 2 Diabetes Mellitus Reviewed

    Omae T, Nagaoka T, Yoshida A.

    Investigative Ophthalmology & Visual Science   56 ( 6 )   4143 - 4149   2015.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    PURPOSE:

    To study the relationship between retinal microcirculation and serum adiponectin, an important adipocytokine secreted by adipocytes, concentrations in patients with type 2 diabetes mellitus.
    METHODS:

    Using a laser Doppler velocimetry system, we simultaneously measured the retinal blood flow (RBF) values and retinal vessel diameter and blood velocity in 64 consecutive Japanese patients (mean age ± SD, 59.8 ± 10.4 years) with type 2 diabetes with no or mild nonproliferative diabetic retinopathy. We compared the values with the RBF and serum adiponectin concentrations in these patients. The patients were divided into two groups based on sex (33 males, 31 females).
    RESULTS:

    The plasma adiponectin concentrations were correlated positively with the retinal vessel diameter (r = 0.480; P = 0.005), retinal blood velocity (r = 0.399; P = 0.02), and RBF (r = 0.518; P = 0.002) and correlated negatively with the retinal arterial vascular resistance (r = -0.598; P = 0.0002) in males, but not females, with type 2 diabetes with early-stage diabetic retinopathy. Multiple regression analysis showed that the plasma adiponectin level was independently and positively correlated with RBF and negatively correlated with retinal arterial vascular resistance.
    CONCLUSIONS:

    Our results indicated that a high concentration of serum adiponectin may be associated with increased RBF, probably via the increased blood velocity and dilated vessel diameter in males with type 2 diabetes with early-phase diabetic retinopathy.

    DOI： 10.1167/iovs.15-16447

  • Vasodilatory mechanisms of unoprostone isopropyl in isolated porcine retinal arterioles Reviewed

    Tanano I, Nagaoka T, Ono S, Omae T, Otani S, Yoshida A

    Molecular of Vision   21   699 - 705   2015.6

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  • Enhanced vitreous imaging optical coherence tomography in primary macular holes Reviewed

    Takahashi A, Nagaoka T, Yoshida A

    International Ophthalmology   36 ( 3 )   355 - 363   2015.6

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    The aim of the current pilot study is to investigate the efficacy of a novel enhanced vitreous imaging (EVI) in primary macular holes (MHs) using a spectral-domain optical coherence tomography (SD-OCT). Thirty-four eyes of 32 consecutive patients with a MH were examined in one time cross-sectional study. The vitreomacular interface was assessed using SD-OCT with conventional and EVI technique. Twenty-three of the 34 eyes did not show a Weiss ring, and in 22 of those, we observed a MH with an open roof or operculum and a detached posterior vitreous cortex with conventional vitreous imaging. Using EVI-OCT, we visualized the reflection of the posterior vitreous with a vitreopapillary attachment. One of the 23 eyes without a Weiss ring had a central round retinal defect without an operculum, and the conventional SD-OCT showed an empty vitreous, suggesting a complete posterior vitreous detachment. However, the EVI-OCT revealed the reflection of the posterior vitreous, and the cortex appeared to still be completely attached. In all the 23 eyes without a Weiss ring, EVI-OCT detected the reflection of the posterior vitreous and vitreopapillary attachment. In all 11 eyes with a Weiss ring (stage 4 hole), EVI-OCT showed an optically empty space in the posterior vitreous cavity without a vitreopapillary attachment. EVI-OCT may be a new reliable method for preoperative evaluations to determine the presence or absence of a complete posterior vitreous detachment in macular diseases with an indistinct Weiss ring.

    DOI： 10.1007/s10792-015-0126-y

  • Role of neuronal nitric oxide synthase in regulating retinal blood flow during flicker-induced hyperemia in cats Reviewed

    Yoshioka T, Nagaoka T, Song YS, Yokota H, Tani T, Yoshida A

    Investigative Ophthalmology & Visual Science   56 ( 5 )   3113 - 3120   2015.5

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1167/iovs.14-15854

  • Serum prorenin levels are not associated with ocular diseases in non-diabetic subjects Reviewed

    Yokota H, Nagaoka T, Sato E, Takahashi A, Shimouchi A, Yoshida A.

    J Renin Angiotensin Aldosterone Syst   16 ( 1 )   153 - 158   2015.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1177/1470320314551442

  • Optical Coherence Tomography Angiography in Diabetic Retinopathy: A Prospective Pilot Study. Reviewed

    Ishibazawa A, Nagaoka T, Takahashi A, Omae T, Tani T, Sogawa K, Yokota H, Yoshida A

    Am J Ophthalmol   160 ( 1 )   35 - 44   2015.1

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  • MACULAR HOLE FORMATION AFTER VITREOMACULAR DETACHMENT WITH AN OPERCULUM.

    Takahashi A, Nagaoka T, Yoshida A

    Retin Cases Brief Rep.   10 ( 1 )   79 - 82   2015.1

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  • Changes in Retinal Blood Flow in Patients with Macular Edema Secondary to Branch Retinal Vein Occlusion before and after Intravitreal Injection of Bevacizumab Reviewed

    Nagaoka T, Sogawa K, Yoshida A.

    Retina   34 ( 10 )   2037 - 2043   2014.10

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    PURPOSE:

    To investigate the effect of intravitreal bevacizumab (IVB) injections for macular edema secondary to acute branch retinal vein occlusion on the retinal microcirculation.
    METHODS:

    The study was a prospective, interventional case series. Central macular thickness using spectral-domain optical coherence tomography and retinal blood flow (RBF) in untreated eyes with macular edema secondary to acute branch retinal vein occlusion in occluded (V1) and opposite venules in affected eyes (V2) and the equivalent venules in contralateral eyes (V3), using laser Doppler velocimetry during follow-up and after IVB injection, were measured.
    RESULTS:

    In 33 eyes with acute branch retinal vein occlusion of <2 months of duration at the first visit, changes in the retinal microcirculation for 1 month was observed; the macular edema improved spontaneously, and the RBF was unchanged in 15 of 33 eyes, and the RBF increased by 23.3% in 18 eyes with persistent macular edema. Twenty-four eyes received an IVB injection (1.25 mg per 0.05 mL). The RBF did not change significantly during follow-up. In 8 of 24 eyes (33%) with improved macular edema 3 months after the treatment, the average RBF values before injection were significantly higher compared with that of eyes with recurrent edema.
    CONCLUSION:

    One IVB injection might have little effect on the retinal microcirculation in patients with macular edema secondary to acute branch retinal vein occlusion at least 3 months after the injection. However, the increased RBF in the occluded venules before injection might be associated with improved macular edema after the IVB injection.

    DOI： 10.1097/IAE.0000000000000172

  • Beraprost Sodium, a Stable Prostacyclin Analogue, Elicits Dilation of Isolated Porcine Retinal Arterioles: Roles of eNOS and Potassium Channels. Reviewed

    Ono S, Nagaoka T, Omae T, Tanano I, Kamiya T, Otani S, Ishibazawa A, Yoshida A.

    Invest Ophthalmol Vis Sci   55 ( 9 )   5752 - 5759   2014.9

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  • Role of Ca2+-Dependent and Ca2+-Sensitive Mechanisms in Sphingosine 1-Phosphate-Induced Constriction of Isolated Porcine Retinal Arterioles in Vitro Reviewed

    2. Kamiya T, Nagaoka T*, Omae T, Yoshioka T, Ono S, Tanano I, Yoshida A.

    Experimental Eye Research   121   94 - 101   2014.4

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    Although sphingosine 1-phosphate (S1P), a bioactive lipid derived from activated platelets, has a variety of physiologic effects on vessels, no reports have described the effect of S1P on the retinal circulation. We examined the effect and underlying mechanism of the vasomotor action of S1P on porcine retinal arterioles. The porcine retinal arterioles were isolated, cannulated, and pressurized without flow for in vitro study. S1P-induced diameter changes were recorded using videomicroscopic techniques. S1P elicited concentration-dependent (1 nM-10 μM) vasoconstriction of the retinal arterioles that was abolished by the S1P receptor 2 (S1PR2) antagonist JTE-013. S1P-induced vasoconstriction was abolished by the Rho kinase (ROCK) inhibitor H-1152 and was inhibited partly by the protein kinase C (PKC) inhibitor Gö-6983. The inhibition of phospholipase C by U73122 and L-type voltage-operated calcium channels (L-VOCCs) by nifedipine inhibited S1P-induced vasoconstriction; a combination of both inhibitors abolished S1P-induced vasoconstriction. Furthermore, inhibition of myosin light chain kinase (MLCK) by ML-9 significantly blocked S1P-induced vasoconstriction; further coadministration of ML-9 with H-1152 or Gö-6983 abolished S1P-induced vasoconstriction. The current data suggest that S1P elicits vasoconstriction of the retinal arterioles via S1PR2 in vascular smooth muscle cells and this vasoconstriction may be mediated by the Ca2+ -sensitive pathway via activation of PKC leading to activation of ROCK and the Ca2+ -dependent pathway via activation of L-VOCCs resulting in activation of MLCK.

    DOI： 10.1016/j.exer.2014.01.011

  • Autoregulation of retinal blood flow in response to decreased ocular perfusion pressure in cats: comparison of the effects of increased intraocular pressure and systemic hypotension Reviewed

    Tani T, Nagaoka T, Nakabayashi S, Yoshioka T, Yoshida A

    Invest Ophthalmol Vis Sc   55 ( 1 )   360 - 367   2014.1

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  • Mechanisms Responsible for Autoregulation of Retinal Blood Flow in Response to Reductions in Ocular Perfusion Pressure in Cats: Comparison of the Effects of Increased Intraocular Pressure and Systemic Hypotension Reviewed

    Tani T, Nagaoka T, Nakabayashi S, Yoshioka T, Yoshida A.

    Investigative Opthalmology & Visual Science   55 ( 1 )   360 - 367   2014.1

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    PURPOSE:

    To investigate the regulatory mechanisms responsible for autoregulation of retinal blood flow (RBF) during periods of decreased ocular perfusion pressure (OPP).
    METHODS:

    The effects of acute reductions in OPP on RBF were assessed using laser Doppler velocimetry in cats. The OPP decreased from 90 to 40 mm Hg by increasing the IOP (elevated IOP) or by decreasing the systemic blood pressure via exsanguination (systemic hypotension). The contributions of nitric oxide (NO), adenosine, and/or N-methyl-D-aspartic acid (NMDA) in regulation of the retinal arteriolar hemodynamics during decreased OPP was determined at 120 minutes after intravitreal injection of various inhibitors or PBS.
    RESULTS:

    Following PBS injection, the flow velocity decreased in proportion to the decrease in OPP; however, the retinal arteriolar diameter gradually increased. Consequently, the RBF was maintained near baseline levels when the OPP exceeded 70 mm Hg but decreased significantly (P < 0.01) when the OPP fell to less than or equal to 60 mm Hg due to elevated IOP or systemic hypotension. Adenosine receptor blocker 8-(p-sulfophenyl)theophylline, significantly (P < 0.01) enhanced decreases in RBF induced by elevated IOP and systemic hypotension at OPP from 80 to 40 mm Hg, whereas NO synthase inhibitor N(G)-nitro-L-arginine-methyl ester and NMDA receptor antagonist DL-2-amino-5-phosphonopentanoic acid only significantly (P < 0.01) enhanced reductions in RBF induced by elevated IOP.
    CONCLUSIONS:

    These results indicate that adenosine contributes to autoregulation of RBF during systemic hypotension, whereas adenosine, NO, and NMDA receptors autoregulate the RBF after elevated IOP. Different vasoregulatory factors might contribute to autoregulation of RBF after decreases in OPP induced by elevated IOP and systemic hypotension.

    DOI： 10.1167/iovs.13-12591

  • Vitreomacular interface in patients with familial exudative vitreoretinopathy Reviewed

    Shimouchi A, Takahashi A, Nagaoka T, Ishibazawa A, Yoshdia A

    International Ophthalmology   33 ( 6 )   711 - 715   2013.12

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    DOI： doi: 10.1007/s10792-012-9707-1

  • Relationship between retinal fractal dimensions and retinal circulation in patients with type 2 diabetes mellitus Reviewed

    Nagaoka T, Yoshida A

    Current Eye Research   38 ( 11 )   148 - 152   2013.11

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    PURPOSE:
    To investigate the relationship between retinal fractal dimensions (Dfs) and retinal circulation, which is impaired in early-stage diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (DM).
    METHODS:
    Using a laser Doppler velocimetry system, we measured the retinal vessel diameter (D) and blood velocity (V) and calculated the retinal blood flow (RBF) in the retinal arterioles and venules in 106 eyes (106 patients, mean age ± standard deviation, 58.7 ± 9.8 years). Patients with type 2 DM had no (n = 86) or mild nonproliferative DR (n = 20). The Dfs were measured on the retinal photographs using a semiautomatic computer-based program.
    RESULTS:
    The average D, V, and RBF in the retinal arterioles and venules were, respectively, 107.9 ± 13.3 and 139.4 ± 20.1 µm, 33.2 ± 7.0 and 22.6 ± 6.1 mm/s and 9.3 ± 2.9 and 10.4 ± 3.8 µl/min. The average Df was 1.4276 ± 0.0193. There was no association between the Df and any retinal circulatory parameters of the retinal arterioles. In contrast, we found significant correlations between the Df and the vessel D (r = 0.37, p = 0.0002) and RBF (r = 0.22, p = 0.026) in the retinal venules.
    CONCLUSION:
    The Df might be associated with changes in the retinal circulation in patients with type 2 DM.

    DOI： 10.3109/02713683.2013.805232.

  • Low shear stress up-regulation of proinflammatory gene expression in human retinal microvascular endothelial cells Reviewed

    Ishibazawa A, Nagaoka T, Yokota H, Ono S, Yoshida A

    Experimental Eye Research   116 ( 11 )   308 - 311   2013.11

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    DOI： doi: 10.1016

  • Adiponectin-induced dilation of isolated porcine retinal arterioles via production of nitric oxide from endothelial cells Reviewed

    Omae T, Nagaoka T, Tanano I, Yoshida A.

    Investigative Ophthalmology & Visual Science   54   4586 - 4594   2013.6

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    PURPOSE:

    Adiponectin, an important adipocytokine secreted by adipocytes, has anti-inflammatory and atheroprotective effects on vascular tissue via the adiponectin receptor (adipoR). However, the action of adiponectin in the retinal microcirculation is unknown. We examined the direct effect and underlying mechanism of the vasomotor action of adiponectin in porcine retinal arterioles.
    METHODS:

    Porcine retinal arterioles (internal diameter, 60-90 μm) were isolated, cannulated, and pressurized (55 cmH2O) without flow in this in vitro study. Videomicroscopic techniques were used to record changes in diameter in response to adiponectin.
    RESULTS:

    The retinal arterioles dilated in a dose-dependent (0.125-7.5 μg/mL) manner in response to adiponectin. The vasodilation decreased significantly after removal of the endothelium. N(G)-nitro-L-arginine methyl ester (a nitric oxide [NO] synthase inhibitor), 1H-1,2,4-oxadia-zolo[4,3-a]quinoxalin-1-one (a soluble guanylyl cyclase inhibitor), but not wortmannin (a phosphatidylinositol 3-kinase inhibitor) inhibited the effect of adiponectin-induced vasodilation comparable with that of denudation. Pretreatment with compound C, an activated protein kinase (AMPK) inhibitor, partially but significantly reduced vasodilation. Incubation with GW6471, a peroxisome proliferator-activated receptor blocker, did not significantly inhibit vasodilation by adiponectin. AdipoR1 and adipoR2 immunoreactions were observed in the endothelium of retinal arterioles.
    CONCLUSIONS:

    Adiponectin elicits mainly endothelium-dependent dilation of the retinal arterioles. Endothelium-dependent vasodilation likely induced by adiponectin results from NO via activation of guanylyl cyclase that is partially dependent on AMPK activity. Understanding the effect of adiponectin on the retinal vasculature may help improve potential therapies for retinal vascular disorders, especially diabetic retinopathy in patients with type 2 diabetes mellitus.

    DOI： 10.1167/iovs.13-11756

  • Relationship between Retinal Blood Flow and Renal Function in Patients with Type 2 Diabetes Mellitus and Chronic Kidney Diseases. Reviewed

    Nagaoka T, Yoshida A.

    Diabetes Care   36 ( 4 )   957 - 961   2013.4

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  • Homocysteine inhibition of endothelium-dependent nitric oxide-mediated dilation of porcine retinal arterioles via enhanced superoxide production. Reviewed

    Omae T, Nagaoka T, Tanano I, Yoshida A.

    Investigative Ophthalmology & Visual Science   54 ( 3 )   2288 - 2295   2013.3

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  • Dilation of porcine retinal arterioles to cilostazol: roles of eNOS phosphorylation via cAMP/protein kinase A and AMP-activated protein kinase and potassium channel. Reviewed

    Tanano I, Nagaoka T, Omae T, Ishibazawa A, Kamiya T, Ono S, Yoshida A.

    Investigative Ophthalmology & Visual Science   54 ( 2 )   1443 - 1449   2013.2

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  • Impaired systemic endothelial function in patients with branch retinal vein occlusion Reviewed

    Tanano I, Nagaoka T, Sogawa K, Tani T, Omae T, Nakabayashi S, Ishibazawa A, Yoshida A.

    Current Eye Research   38 ( 1 )   114 - 118   2013.1

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  • Idiopathic Full-thickness Macular Holes and the Vitreomacular Interface: A High-Resolution Spectral-Domain Optical Coherence Tomography Study. Reviewed

    Takahashi A, Yoshida A, Nagaoka T, Takamiya A, Sato E, Kagokawa H, Kameyama D, Sogawa K, Ishiko S, Hirokawa H

    American Journal of Ophthalmology   154 ( 5 )   881 - 892   2012.11

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  • Retinal arteriolar responses to acute severe elevation in systemic blood pressure in cats: Role of endothelium-derived factors. Reviewed

    Nakabayashi S, Nagaoka T*, Tani T, Sogawa K, Hein TW, Kuo L, Yoshida A. Yoshida A

    Eeperimental Eye Research   103 ( 10 )   63 - 70   2012.10

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  • Relationship between Choroidal Thickness and Choroidal Circulation in Healthy Young Subjects. Reviewed

    Sogawa K,　Nagaoka T*(Corresponding author), Takahashi A, Tanano I, Tani T, Ishibazawa A, Yoshida A.

    Am J Ophthalmol   153 ( (6) )   1129 - 1132   2012.6

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  • Effects of topical carteolol on retinal arterial blood flow in primary open-angle glaucoma patients Reviewed

    Kawai M, Nagaoka T, Takahashi A, Sato E, Yoshida A

    Japanese journal of Ophthalmology   56 ( 5 )   458 - 463   2012.5

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  • Association Between Diabetic Retinopathy and Flow-Mediated Vasodilation in Type 2 DM. Reviewed

    Sogawa K, Nagaoka T, Tanano I, Tani T, Omae T, Nakabayashi S, Ishibazawa A, Takahashi A, Yoshida A.

    Current Eye Research   37 ( (5) )   446 - 451   2012.5

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  • Fenofibrate, an Anti-Dyslipidemia Drug, Elicits the Dilation of Isolated Porcine Retinal Arterioles: Role of Nitric Oxide and AMP-Activated Protein Kinase. Reviewed

    Omae T, Nagaoka T*(Corresponding author), Tanano I, Kamiya T, Yoshida A.

    Invest Ophthalmol Vis Sci   53 ( (6) )   2880 - 2886   2012.5

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  • Correlation between Plasma Pentosidine Concentrations and Retinal Hemodynamics in Patients with Type 2 Diabetes. Reviewed

    Sato E, Nagaoka T, Yokota H, Takahashi A, Yoshida A.

    Am J Ophthalmol   153 ( (5) )   903 - 909   2012.5

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  • Indirect imaging of branch retinal vein occlusion using a scanning laser ophthalmoscope. Reviewed

    Ishiko S, Yoshida A, Sato E, Kato Y, Nagaoka T, Van de Velde F.

    Jpn J Ophthalmol   55 ( (3) )   307 - 309   2011.5

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  • Centrifugal Enlargement Of Macular Hole And Macular Detachment in A Patient With Bilateral Giant Macular Holes.

    Takahashi A, Nagaoka T, Kagokawa H, Ishiko S, Yoshida A*.

    Retinal Cases & Brief Reports   5 ( (3) )   184 - 188   2011.4

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  • Neuroprotection from Retinal Ischemia/Reperfusion Injury by NOX2 NADPH Oxidase Deletion. Reviewed

    Yokota H, Subhadra N, Wenbo Z, Hua L, Modesto R, Zhimin X, Tahira L, Nagaoka T, Yoshida A, Steven B, Caldwell RW, Caldwell RB.

    Invest Ophthalmol Vis Sci   52 ( (11) )   8123 - 8131   2011.4

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  • Effects of Shear Stress on the Gene Expressions of Endothelial Nitric Oxide Synthase, Endothelin-1, and Thrombomodulin in Human Retinal Microvascular Endothelial Cells.

    Ishibazawa A, Nagaoka T*(Corresponding author), Takahashi T, Yamamoto K, Kamiya A, Ando J, Yoshida A.

    Invest Ophthalmol Vis Sci   52 ( (11) )   8496 - 8504   2011.4

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  • Pioglitazone, a peroxisome proliferator-activated receptor-γ agonist, induces dilation of isolated porcine retinal arterioles: role of nitric oxide and potassium channels

    Omae T, Nagaoka T*(Corresponding author), Tanano I, Yoshida A.

    Invest Ophthalmol Vis Sci   52 ( (9) )   6749 - 6756   2011.4

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  • Higher levels of prorenin predict development of diabetic retinopathy in patients with type 2 diabetes.

    Yokota H, Nagaoka T, Tani T, Takahashi A, Sato E, Kato Y, Yoshida A.

    Journal of the Renin-Angiotensin-Aldosterone System   12 ( (3) )   290 - 294   2011.4

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  • Macular Hole Formation in Fellow Eyes with a Perifoveal Posterior Vitreous Detachment of Patients with a Unilateral Macular Hole.

    Takahashi A, Yoshida A, Nagaoka T, Kagokawa H, Kato Y, Takamiya A, Sato E, Yokota H, Ishiko S, Hirokawa H.

    American Journal of Ophthalmology   151 ( (6) )   981 - 989   2011.4

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  • Stage 1-A Macular Hole: A Prospective Spectral-Domain Optical Coherence Tomography Study. Reviewed

    Takahashi A, Nagaoka T, Yoshida A.

    Retina   31 ( (1) )   127 - 147   2011.4

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Central Corneal Thickness Measurements with Fourier-Domain Optical Coherence Tomography versus Ultrasonic Pachymetry and Rotating Scheimpflug Camera.

    Ishibazawa A, Igarashi S, Hanada K, Nagaoka T, Ishiko S, Ito H, Yoshida A.

    Cornea   30 ( (6) )   615 - 619   2011.4

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  • Macular Microhole of the Outer Retinal Defect with a Perifoveal Posterior Vitreous Detachment. Reviewed

    Takahashi A, Ishiko S, Nagaoka T, Kato Y, Kameyama D, Yoshida A.

    Ophthalmic Surgery, Lasers and Imaging   9   1 - 4   2010.4

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  • Acute Hyperglycemia Induces Endothelial Dysfunction in the Retinal Arterioles in Cats Reviewed

    Sogawa K, Nagaoka T*(Corresponding author), Izumi N, Nakabayashi S, Yoshida A

    Invest Ophthalmol Vis Sci   51   2648 - 2655   2010.4

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  • Impaired retinal circulation in patients with type 2 diabetes mellitus:Retinal Laser Doppler velocimetry study Reviewed

    Nagaoka T*(Corresponding author), Sato E, Takahashi A, Yokota H, Sogawa K, Yoshida A.

    Invest Ophthalmol Vis Sci   51   6729 - 6734   2010.4

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  • Foveal Anatomic Changes in a Progressing Stage 1 Macular Hole Documented by Spectral Domain Optical Coherence Tomography Ophthalmology. Reviewed

    Takahashi A, Nagaoka T, Ishiko S, Kameyama D, Yoshida A

    Ophthalmology   117   806 - 810   2010.4

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  • Spontaneous outer retinal closure of stage 1B macular hole without vitreofoveal separation. Reviewed

    Takahashi A, Nagaoka T, Kato Y, Ishiko S, Yoshida A.

    Int Ophthalmol   30 ( (6) )   731 - 734   2010.4

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  • 前眼部光干渉断層計を用いて観察した糖尿病角膜症

    花田一臣　五十嵐羊羽　石子智士　加藤祐司　小川俊彰　長岡泰司　川井基史　石羽澤明弘　吉田晃敏

    あたらしい眼科   26   247 - 253   2009.4

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  • A mathematical model for the distribution of hemodynamic parameters in the human retinal microvascular network. Reviewed

    Takahashi T, Nagaoka T, Yanagida H, Saitoh T, Kamiya A, Hein T, Kuo L, Yoshida A

    J Biorheol   23   77 - 86   2009.4

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  • Effect of aging on retinal circulation in normotensive healthy subjects. Reviewed

    Nagaoka T*(Corresponding author), Sato E, Takahashi A, Sogawa K, Yokota H, Yoshida A.

    Exp Eye Res   89   887 - 891   2009.4

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  • Functional and Molecular Characterization of the Endothelin System in Retinal Arterioles Reviewed

    Hein T, Ren Y, Yuan Z, Xu W, Somvanshi S, Nagaoka T, Yoshida A, Kuo L

    Invest Ophthalmol Vis Sci   50   3329 - 3336   2009.4

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  • Macular Microcirculation and Macular Oedema in Branch Retinal Vein Occlusion. Reviewed

    Noma H, Funatsu H, Sakata K, Harino S, Nagaoka T, Mimura T, Sone T, Hori S

    Br J Ophthalmol   93   630 - 633   2009.4

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  • Effect of Systemic Administration of Valsaltan, an Angiotensin II Type 1 Receptor Blocker, on Retinal Circulation in healthy humans. Reviewed

    Nagaoka T*(Corresponding author), Takahashi A, Sato E, Yokota A, Izumi N, Takahashi A, Yoshida A.

    Eye.   23   1491 - 1492   2009.4

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  • 網膜動脈循環動態変化を測定した網膜動脈分枝閉塞症の１例

    1. 大前恒明 高橋淳士 長岡泰司 石子智士 佐藤栄一 吉田晃敏

    日本眼科学会雑誌   113 ( 8 )   800 - 807   2009.4

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  • 両眼嚢胞様黄斑浮腫を合併した若年者網膜色素変性の長期治療経過と中心窩脈絡膜循環変化

    2. 高橋淳士 長岡泰司 佐藤栄一 北谷智彦 石子智士 吉田晃敏.

    日本眼科学会雑誌   113 ( 6 )   656 - 663   2009.4

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  • 先天眼トキソプラズマ症例の再発時における治療前後の光干渉断層計所見変化.

    3. 伊藤はる奈 高橋淳士 長岡泰司 福井勝彦 吉田晃敏.

    臨床眼科   63 ( 5 )   769 - 774   2009.4

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  • 19歳若年者に発症した網膜中心静脈閉塞症に伴う漿液性網膜剥離の１例.

    4. 亀山大希 高橋淳士 長岡泰司 吉田晃敏

    臨床眼科   63 ( 4 )   545 - 549   2009.4

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  • 光干渉断層計にて網膜色素上皮層の不整の再発を認めた交感性眼炎の１例

    5. 石羽澤明弘 加藤祐司 高橋淳士 長岡泰司 木ノ内玲子 籠川浩幸 石子智士 吉田晃敏

    臨床眼科   63 ( 4 )   571 - 575   2009.4

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  • Effect of Panretinal Photocoagulation on Choroidal Circulation in the Foveal Region in Patients with Severe Diabetic Retinopathy. Reviewed

    Takahashi A, Nagaoka T*(Corresponding author), Sato E, Yoshida A.

    Br J Ophthalmol   92   1369 - 1373   2008.4

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  • Role of Nitric Oxide in Regulation of Retinal Blood Flow in Response to Hyperoxia in Cats. Reviewed

    Izumi N, Nagaoka T*(Corresponding author), Sato E, Sogawa K, Kagokawa H, Takahashi A, Kawahara A, Yoshida A.

    Invest Ophthalmol Vis Sci   49   4595 - 4603   2008.4

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  • Short-term effects of topical tafluprost on retinal blood flow in cats. Reviewed

    11. Izumi N, Nagaoka T, Sato E, Mori F, Takahashi A, Sogawa K, Yoshida A

    Journal of Ocular Pharmacology & Therapeutics   24 ( 5 )   521 - 526   2008.4

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  • Role of prorenin in the pathogenesis of retinal neovascularization.

    12. Yokota H, Takamiya A, Nagaoka T, Hikichi T, Ishida Y, Suzuki F, Yoshida A

    Hokkaido Igaku Zasshi.   83 ( 3 )   159 - 165   2008.4

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  • C-Reactive Protein Inhibits Endothelium-Dependent Nitric Oxide-Mediated Dilation of Retinal Arterioles via Enhanced Superoxide Production. Reviewed

    Nagaoka T*(Corresponding author), Kuo L, Yoshida A, Hein T

    Invest Ophthalmol Vis Sci   49   2053 - 2060   2008.4

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  • 強膜内陥術後に黄斑裂孔を生じた家族性滲出性硝子体網膜症の１例.

    高橋淳士、籠川浩幸、長岡泰司、横田陽匡、吉田晃敏.

    眼科手術   21 ( 4 )   533 - 537   2008.4

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  • 大動脈弁閉鎖不全症の手術前後で網膜動脈循環動態を測定した高安動脈炎の１例

    高橋淳士、長岡泰司、佐藤栄一、吉田晃敏

    日本眼科紀要   58 ( 10 )   611 - 615   2007.4

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  • Resveratrol, a Component of Red Wine, Elicits Dilation of Isolated Porcine Retinal Arterioles: Role of Nitric Oxide and Potassium Channels. Reviewed

    14. Nagaoka T*(Corresponding author), Hein T, Yoshida A, Kuo L

    Invest Ophthalmol Vis Sci   48 ( 9 )   4232 - 4239   2007.4

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  • Prorenin levels in retinopathy of prematurity.

    15. Yokota H, Nagaoka T, Mori F, Hikichi T, Hosokawa H, Tanaka H, Ishida Y, Suzuki F, Yoshida A

    Am J Ophthalmol.   143 ( 3 )   531 - 533   2007.4

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  • Simvastatin Elicits Dilation of Isolated Porcine Retinal Arterioles: Role of Nitric Oxide and Mevalonate-Rho Kinase Pathway.

    16. Nagaoka T*(Corresponding author), Hein T, Yoshida A, Kuo L

    Invest Ophthalmol Vis Sci   48 ( 5 )   825 - 832   2007.4

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  • Retinal circulatory changes associated with interferon-induced retinopathy in patients with hepatitis C.

    17. Nagaoka T*(Corresponding author), Sato E, Takahashi A, Yokohama S, Yoshida A

    Invest Ophthalmol Vis Sci   48 ( 1 )   368 - 375   2007.4

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  • Relation between plasma nitric oxide levels and diabetic retinopathy.

    19. Izumi N, Nagaoka T*(Corresponding author), Mori F, Sato E, Takahashi A, Yoshida A.

    Jpn J Ophthalmol   50 ( 5 )   465 - 468   2006.9

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  • Choroidal blood flow in the foveal region in eyes with rhegmatogenous retinal detachment and scleral buckling procedures.

    18. Sugawara R, Nagaoka T*(Corresponding author), Kitaya N, Fujio N, Takahashi J, Takahashi A, Yokota H, Yoshida A

    Br J Ophthalmol.   90 ( 11 )   1363 - 1365   2006.4

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  • Inhibitory Effect of bucillamine on the increased leukocyte entrapment in the retinal microcirculation of diabetes rats. Reviewed

    Mori F, Takahashi J, Nagaoka T, Abiko T, Hikichi T, Yoshida A.

    Jpn J Ophthalmol   50   377 - 379   2006.4

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  • Noninvasive evaluation of wall shear stress on retinal microcirculation in humans. Reviewed

    Nagaoka T*(Corresponding author), Yoshida A

    Invest Ophthalmol Vis Sci   47   1113 - 1119   2006.4

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  • Effect of systemic administration of statin on retinal circulation. Reviewed

    Nagaoka T*(Corresponding author), Takahashi A, Sato E, Izumi N, Hein T, Kuo L, Yoshida A

    Arch Ophthalmol   124   665 - 670   2006.4

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  • Retinal changes in juvenile X-linked retinoschisis using three dimensional optical coherence tomography.

    Minami Y, Ishiko S, Takai Y, Kato Y, Kagokawa H, Takamiya A, Nagaoka T, Kinouchi R, Yoshida A

    Br J Ophthalmol   89   1663 - 1664   2005.4

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  • Serum prorenin levels and diabetic retinopathy in type 2 diabetes: new method to measure serum level of prorenin using antibody activating direct kinetic assay.

    Yokota H, Mori F, Kai K, Nagaoka T, Izumi N, Takahashi A, Hikichi T, Yoshida A, Suzuki F, Ishida Y.

    Br J Ophthalmol   89   871 - 873   2005.4

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  • Pulsatile ocular blood flow: changes associated with scleral buckling procedures.

    Yokota H, Mori F, Nagaoka T, Sugawara R, Yoshida A.

    Jpn J Ophthalmol   49   162 - 165   2005.4

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  • The relationship between the parameters of retinal circulation measured by a laser Doppler velocimetry and a marker of early systemic atherosclerosis.

    Nagaoka T*(Corresponding author), Ishii Y, Takeuchi Y, Takahashi A, Sato E, Yoshida A

    Invest Ophthalmol Vis Sci   46   420 - 425   2005.4

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  • The effect of ocular warming on ocular circulation in healthy humans.

    Nagaoka T*(Corresponding author), Yoshida A

    Arch Ophthalmol   122   1477 - 1481   2004.4

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  • Alteration of choroidal circulation in the foveal region in patients with type 2 diabetes.

    Nagaoka T*(Corresponding author), Kitaya N, Sugawara R, Yokota H, Mori F, Hikichi T, Fujio N, Yoshida A.

    Br J Ophthalmol   88   1060 - 1063   2004.4

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  • Effect of hemodialysis on retinal circulation in patients with end-stage renal disease.

    Nagaoka T*(Corresponding author), Takeyama Y, Kanagawa S, Sakagami K, Mori F, Yoshida A

    Br J Ophthalmol   88   1026 - 1029   2004.4

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  • Peroxynitrite decomposition catalyst, FP15, and poly(ADP-ribose) polymerase inhibitor, PJ34, inhibit leukocyte entrapment in the retinal microcirculation of diabetic rats.

    Sugawara R, Hikichi T, Kitaya N, Mori F, Nagaoka T, Yoshida A, Szabo C.

    Curr Eye Res   29   11 - 16   2004.4

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  • シックハウス症候群の眼血流動態

    長岡泰司、佐藤栄一、高橋淳士、吉田晃敏

    臨床環境医学   13 ( 2 )   51 - 54   2004.4

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  • 塩酸ブナゾシン点眼が健常人の網膜と脈絡膜循環に及ぼす影響

    高橋淳士、長岡泰司、佐藤栄一、横田陽匡、菅原亮一、吉田晃敏

    臨床眼科   58 ( 6 )   1091 - 1095   2004.4

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  • Role of nitric oxide in regulation of retinal blood flow during hypercapnia in cats Reviewed

    Sato E, Sakamoto T, Nagaoka T, Mori F, Takakusaki K, Yoshida A.

    Invest Ophthalmol Vis Sci   44   4947 - 4953   2003.11

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  • Pulsatile ocular blood flow study: unaffected in type 2 diabetes mellitus Reviewed

    Mori F, Yokota H, Nagaoka T, Konno S, Kagokawa H, Hikichi T, Yoshida A

    Japanese journal of Ophthalmology   6   621 - 622   2003.11

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  • Features of abnormal choroidal circulation in central serous chorioretinopathy Reviewed

    Kitaya N, Nagaoka T, Hikichi T, Sugawara R, Fukui K, Ishiko S, Yoshida A.

    British Journal of Ophthalmology   87   709 - 712   2003.6

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  • Reproducibility and clinical application of a newly developed stabilized retinal laser Doppler instrument Reviewed

    52. Yoshida A, Feke GT, Mori F, Nagaoka T, Fujio N, Ogasawara H, Konno S, McMeel JW

    American Journal of Ophthalmology   135   356 - 361   2003.3

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  • The effect of nitric oxide on retinal blood flow during hypoxia in cats Reviewed

    Nagaoka T, Sakamoto T, Mori F, Sato E, Yoshida A.

    Investigative Ophthalmology & Visual Science   43   3037 - 3044   2002.12

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  • Inhibitory effect of losartan, an AT1 angiotensin II receptor antagonist, on increased leucocyte entrapment in retinal microcirculation of diabetic rats Reviewed

    Mori F, Hikichi T, Nagaoka T, Takahashi J, Kitaya N, Yoshida A

    British Journal of Ophthalmology   86   1172 - 1174   2002.10

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  • Dysfunction of active transport of blood-retinal barrier in patients with clinically significant macular edema in type 2 diabetes Reviewed

    Mori F, Hikichi T, Takahashi J, Nagaoka T, Yoshida A

    Diabetes Care   25 ( 7 )   1248 - 1249   2002.7

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  • Retinal artery response to acute systemic blood pressure increase during cold pressor test in humans Reviewed

    Nagaoka T, Mori F, Yoshida A

    Investigative Ophthalmology & Visual Science   43   1941 - 1945   2002.6

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  • Comparison of short- and long-term effects of betaxolol and timolol on human retinal circulation Reviewed

    Yoshida A, Ogasawara H, Fujio N, Konno S, Ishiko S, Kitaya N, Kagokawa H., Nagaoka T., Hirokawa H

    Eye   12   848 - 853   1998.12

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  • Radiating retinal folds detected by scanning laser ophthalmoscopy using a diode laser in a dark-field mode in idiopathic macular holes Reviewed

    Yoshida A, Ishiko S, Akiba J, Kitaya N, Nagaoka T

    GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY   236 ( 6 )   445 - 450   1998.6

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  • Effect of timolol and UF-021 (a prostaglandin-related compound) on pulsatile ocular blood flow in normal volunteers Reviewed

    Kitaya N, Yoshida A, Ishiko S, Mori F, Abiko T, Ogasawara H, Kato Y, Nagaoka T

    Ophthalmic Research   29 ( 3 )   139 - 144   1997.3

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Books

  • 眼科臨床に必要な解剖生理, VI. 網膜・脈絡膜 ４．網膜の血流. 眼科プラクティス6

    長岡泰司（ Role： Sole author）

    文光堂  2008.4 

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    Language：Japanese   Book type：Scholarly book

  • 糖尿病網膜症の診断, 循環動態, レーザードップラ法. New Mook 眼科 8 糖尿病網膜症

    長岡泰司、吉田晃敏（ Role： Joint author）

    金原出版  2006.4 

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    Language：Japanese   Book type：Scholarly book

  • II循環の生理　網膜循環調節と血流自己調節機構. New Mook 眼科 7 眼循環　28-32

    長岡泰司、吉田晃敏（ Role： Joint author）

    金原出版  2004.4 

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    Language：Japanese   Book type：Scholarly book

  • Ⅳ　循環の生理　1.眼循環と一酸化窒素. New Mook 眼科 7 眼循環　152-157.

    長岡泰司、吉田晃敏（ Role： Joint author）

    金原出版  2004.4 

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    Language：Japanese   Book type：Scholarly book

  • III 種々の眼循環測定法　A Laser Doppler 2 Flowmeter-脈絡膜-. New Mook 眼科 7 眼循環　74-77

    吉田晃敏、長岡泰司（ Role： Joint author）

    金原出版  2004.4 

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    Language：Japanese   Book type：Scholarly book

  • III 種々の眼循環測定法　A Laser Doppler 1 Velocimetry-網膜-. New Mook 眼科 7 眼循環　70-73

    吉田晃敏、長岡泰司（ Role： Joint author）

    金原出版  2004.4 

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MISC

  • 眼循環に着目した糖尿病網膜症・黄斑浮腫の病態と新規治療法開発の可能性

    長岡泰司

    あたらしい眼科   32 ( 3 )   331 - 337   2015.3

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    Authorship：Lead author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)   Publisher：メディカル葵出版  

  • 脈絡膜循環と糖尿病

    長岡泰司

    臨床眼科   69 ( 2 )   142 - 147   2015.2

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    Authorship：Lead author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)   Publisher：医学書院  

  • 画像診断―最近の進歩― 総論：正常眼（被検者）の読影のノウハウー2．眼底血流測定装置　３）Laser Doppler Velocimetry

    長岡泰司

    眼科   2010.4

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  • 糖尿病網膜症・黄斑症の病態：血流動態の面から

    長岡泰司

    あたらしい眼科   2010.4

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    Authorship：Lead author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • レーザードップラー法を用いた糖尿病患者における網膜循環動態測定

    2. 長岡泰司

    Diabetes　Journal   37 ( 1 )   31 - 33   2009.4

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    Authorship：Lead author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • 眼底画像所見を読み解くAdvanced Techniqueレーザードップラーとレーザースペックル

    長岡泰司

    眼科臨床プラクティス   21   2008.6

    　More details

    Authorship：Lead author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • 網膜硝子体診療update　検査法update　眼循環検査

    1. 長岡泰司

    臨床眼科(増刊号)   62 ( 11 )   2008.4

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  • 網膜循環の解析.糖尿病性細小血管症

    4. 長岡泰司、吉田晃敏

    日本臨床　増刊号   63 ( 6 )   220 - 225   2005.4

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    Authorship：Lead author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • 糖尿病網膜症での網膜血流. 特集　糖尿病網膜症—最近の進歩

    5. 長岡泰司、吉田晃敏

    Diabetes Frontier   15   288 - 292   2004.4

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    Authorship：Lead author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

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Presentations

  • Ocular blood flow in diabetic retinopathy International conference

    TAIJI NAGAOKA

    Annual meeting of the Association for Re 

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    Event date： 2014.5

    Language：English   Presentation type：Symposium, workshop panel (nominated)  

    Venue：Orlando, Florida, USA  

  • Mechanisms of the Neurovascular Coupling in the Retina: Role of Neuronal Nitric Oxide Synthase and Glial Cells in Regulating Retinal Blood Flow during Flicker-Induced Hyperemia in Cats. International conference

    Nagaoka T.

    10th World Congress for Microcirculation 

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    Event date： 2015.9

    Language：English   Presentation type：Symposium, workshop panel (nominated)  

    Venue：Kyoto, Japan  

  • Imaging of corneal sub-basal whorl-like nerve plexus in diabetes patients using in vivo corneal confocal microscopy International conference

    Utsunomiya T, Nagaoka T, Hanada K, Omae T, Yokota H, Yoshida A.

    ARVO 

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    Event date： 2015.5

    Language：English   Presentation type：Poster presentation  

  • Clinical evaluation of vascular lesions in Diabetic Retinopathy Using Optical Coherence Tomography Angiography. International conference

    Ishibazawa A, Nagaoka T, Takahashi A, Omae T, Tani T, Sogawa K, Yokota H, Yoshida A.

    ARVO 

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    Event date： 2015.5

    Language：English   Presentation type：Poster presentation  

  • Evaluation of Molecular Mechanism of Retinal Neurovascular Coupling Using Isolated Porcine Retinal Arterioles International conference

    Ono S, Nagaoka T, Omae T, Otani S, Yoshida A.

    ARVO 

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    Event date： 2015.5

    Language：English   Presentation type：Poster presentation  

  • The Role of Glial Cells in the Regulation of Retinal Microcirculation in Response to Modulations in Systemic Oxygen Tension in Cats International conference

    Song YS, Nagaoka T, Yoshioka T, Tani T, Nakabayashi S, Yoshida A

    ARVO 

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    Event date： 2015.5

    Language：English   Presentation type：Poster presentation  

  • Analysis of retinal blood flow velocity profiles using spectral domain doppler optical coherence tomography in a patient with Takayasu's arteritis. International conference

    Tani T, Nagaoka T, Takahashi A, Sogawa K, Omae T, Ishibazawa A, Nakabayashi S, Yoshida A.

    ARVO 

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    Event date： 2015.5

    Language：English   Presentation type：Poster presentation  

  • Role of Neuronal Nitric Oxide Synthase in Regulating Retinal Blood Flow in Response to Flicker-Induced Hyperemia in Cats International conference

    Nagaoka T.

    Association for Ocular Pharmacology and Therapeautics Meeting 

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    Event date： 2015.3

    Language：English   Presentation type：Symposium, workshop panel (nominated)  

    Venue：Charleston, South Carolina  

  • Evaluation of Retinal Venous Blood Flow Velocity Profiles Using SpectralpDomein Doppler Optic Coherence Tomography in Healthy Young Subjects International conference

    Taiji Nagaoka, Tomofumi Tani, Akihiro Ishibazawa, Seigo Nakabayashi, Tsuneaki Omae, Kenji Sogawa, Akitoshi Yoshida

    Annual meeting of the Association of Research for Vision & Ophthalmology 

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    Event date： 2014.5

    Language：English   Presentation type：Poster presentation  

    Venue：Orlando, Florida, USA  

  • 網膜微小循環障害の観点からみた糖尿病網膜症の病態解明

    長岡泰司

    日本眼科学会総会 

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    Event date： 2014.4

    Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

    Venue：東京  

    我々の臨床研究の結果から、2型糖尿病網膜症では発症前あるいは発症早期では網膜血流が低下するという結果が得られており、網膜微小循環障害が糖尿病網膜症の病態に関与していると考えられる。網膜微小循環調節には血管拡張因子と収縮因子がバランス良く関与することが重要であるが、糖尿病ではこのバランスが崩れることが報告されている。具体的には、重要な血管拡張物質である一酸化窒素（NO）の血管内皮からの産生が早期から低下することが示されており、さらに酸化ストレスが増加するとNOはフリーラジカルとして血管障害性に働き、網膜血管内皮機能の低下は、白血球接着増加を介して糖尿病血管障害を悪化させると考えられる。一方、強力な血管収縮因子であるエンドセリン(ET)の産生が糖尿病で増加すると報告されており、これが血流障害に関与すると考えられる。また、血管内皮増殖因子VEGFやレニンーアンジオテンシン系も糖尿病網膜症の病態として重要な因子であり、糖尿病網膜症患者での硝子体中濃度の増加が報告されているため、網膜循環への影響についても考慮されなければならない。
    　微小循環障害の側面から糖尿病網膜症の病態を捉えることにより、新しい治療法開発につながることが期待される。本講演ではその可能性について考えてみたい。

  • Laser Treatment of Diabetic Retinopathy International conference

    TAIJI NAGAOKA

    World Congress of Ophthalmology 

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    Event date： 2014.4

    Language：English   Presentation type：Symposium, workshop panel (public)  

  • 眼循環測定の近未来

    長岡泰司

    日本臨床眼科学会総会 

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    Event date： 2013.10 - 2014.11

    Language：English   Presentation type：Symposium, workshop panel (nominated)  

    Venue：横浜  

  • 糖尿病網膜症と腎症・全身因子との関わり

    長岡泰司

    日本糖尿病合併症学会 

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    Event date： 2013.9

    Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

    Venue：旭川  

    網膜光凝固術や硝子体手術、眼局所薬物治療など糖尿病網膜症に対する治療法の進歩にもかかわらず、未だ年間3000人もの糖尿病網膜症患者が失明に至るという事実は、眼局所での治療法のみでは限界があることを示しており、糖尿病網膜症の治療には、眼局所因子のみならず全身因子の影響も十分考慮する必要がある。最近の大規模臨床研究の成果から、高血圧治療薬であるアンジオテンシン変換酵素(ACE)阻害剤 (UKPDS study)に加えてアンジオテンシンII受容体拮抗薬(ARB)カンデサルタン(DIRECT study)や脂質異常症治療薬フィブラート(FIELD study)も糖尿病網膜症の抑制効果を有することが示され、眼科的治療のみならず薬物内服療法を加え、全身因子の影響を考慮した集学的治療を行う必要がある。
    　これまで我々は、我が国の糖尿病患者の大部分を占める2型糖尿病患者を対象として、レーザードップラ眼底血流計を用いて非侵襲的に網膜循環を評価し、網膜動脈血流量が糖尿病網膜症発症前からすでに低値であること、血中LDLやクレアチニンが網膜血流低下に関与することを報告した(IOVS, 2010)。さらに腎機能と網膜循環との関連に着目して解析を進め、早期の網膜症および腎症を有する２型糖尿病では、腎機能障害が進行すると網膜血流も低下していることを見いだした(Diabetes Care, 2013)。そこで我々は、眼循環障害を改善させる薬剤を探索し、新しい網膜硝子体疾患治療法の開発につながることが期待され、実際我々は摘出血管を用いたex vivo実験系で、脂質異常症改善薬スタチン(IOVS, 2007)およびフェノフィブラート(IOVS, 2012)、インスリン抵抗性改善薬ピオグリタゾン(IOVS, 2011)、PDE阻害剤シロスタゾール（IOVS, 2013）などの薬剤が網膜細動脈を拡張させることを報告し、これら薬剤の網膜血流改善作用が、糖尿病網膜症の発症・進展予防に役立つ可能性を示してきた。
    　本講演では、糖尿病網膜症に影響を与える全身因子について、特に同じ糖尿病細小血管症である腎症との関わりについて、これまでの我々の施設で得られた研究データも加えて概説し、糖尿病網膜症による失明予防のための眼科と内科の連携の重要性について考えてみたい。

  • ドップラー法を用いた眼循環測定

    長岡泰司

    日本眼循環学会 

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    Event date： 2013.7

    Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

    Venue：東京  

  • Measurement of Retinal Blood Flow Using a Newly Developed Doppler Fourier-Domain Optical Coherence Tomography Instruments in Cats International conference

    Taiji Nagaoka, Tomofumi Tani, Eiichi Sato, Takafumi Yoshioka, Kenji Sogawa, Seigo Nakabayashi, Akitoshi Yoshida)

    ARVO meeting 

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    Event date： 2013.5

    Language：English   Presentation type：Poster presentation  

    Venue：Seattle, USA  

  • Impaired Vascular Endothelial Function in Patients with Diabetic Macular Edema International conference

    Kengo Takahashi, Taiji Nagaoka, Akihiro Ishibazawa, Kenji Sogawa, and Akitoshi Yoshida

    ARVO meeting 

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    Event date： 2013.5

    Language：English   Presentation type：Poster presentation  

    Venue：Seattle, USA  

  • Association between diabetic macular edema and chronic kidney disease among patients with type 2 diabetes International conference

    Akihiro Ishibazawa, Taiji Nagaoka, Kengo Takahashi, Atsushi Takahashi, Harumasa Yokota, and Akitoshi Yoshida

    ARVO meeting 

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    Event date： 2013.5

    Language：English   Presentation type：Poster presentation  

    Venue：Seattle, USA  

  • The effect of nitric oxide on increased retinal blood flow in response to flicker stimuli in cats. International conference

    Takafumi Yoshioka, Taiji Nagaoka, Akitoshi Yoshida

    ARVO meeting 

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    Event date： 2013.5

    Language：English   Presentation type：Poster presentation  

    Venue：Seattle, USA  

  • Sphingosine 1-phosphate elicits constriction of isolated porcine retinal arterioles International conference

    Takayuki Kamiya, Taiji Nagaoka, Tsuneaki Omae, Shinji Ono, Akitoshi Yoshida

    ARVO meeting 

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    Event date： 2013.5

    Language：English   Presentation type：Poster presentation  

    Venue：Seattle, USA  

  • Measurement of Retinal Blood Flow Velocity Using a Newly Developed Doppler Fourier-Domain Optical Coherence Tomography Instruments in Humans International conference

    Akitoshi Yoshida, Taiji Nagaoka, Tomofumi Tani, Eiichi Sato, Takafumi Yoshioka, Kenji Sogawa, Seigo Nakabayashi

    ARVO meeting 

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    Event date： 2013.5

    Language：English   Presentation type：Poster presentation  

    Venue：Seattle, USA  

  • Effect of Intravitreal Bevacizmab on Retinal Circulation in Patients with Macular Edema Secondary to Branch Retinal Vein Occlusion. International conference

    TAIJI NAGAOKA, KENJI SOGAWA, EIICHI SATO, ATSUSHI TAAHASHI, AKITOSHI YOSHIDA.

    ARVO meeting 

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    Event date： 2011.4

    Language：English   Presentation type：Poster presentation  

    Venue：Sydney, Australia  

  • Retinal blood flow in diabetes International conference

    長岡泰司

    The 9th International symposium on ocular pharmacology and therapeutics 

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    Event date： 2010.12

    Language：English   Presentation type：Symposium, workshop panel (nominated)  

    Venue：Macao, China  

  • 眼循環測定の有用性と眼血流イメージングを用いた眼循環評価の可能性

    長岡泰司

    第27回日本眼循環学会 

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    Event date： 2010.7

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：神戸市  

  • Macular Hole Development in Fellow Eyes of Patients with a Unilateral Macular Hole: An Optical Coherence Tomography Study. International conference

    A.Takahashi, T. Nagaoka, H. Kagokawa, Y. Kato, A. Takamiya, E. Sato, S. Ishiko, A. Yoshida.

    ARVO meeting 

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    Event date： 2010.4

    Language：English   Presentation type：Poster presentation  

  • Effect of Systemic Hypertension and Dyslipidemia on the Relationship Between Serum Prorenin and Retinal Blood Flow in Type 2 Diabetes Patients. International conference

    T. tani, T. Nagaoka, H. Yokota, A. Takahashi, K. Sogawa, T. Omae, S. Nakabayashi, I. Tanano, A. Ishibazawa, A. Yoshida.

    ARVO meeting 

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    Event date： 2010.4

    Language：English   Presentation type：Poster presentation  

  • Correlation Between Plasma Pentosidine Concentrations and Retinal Hemodynamics in Patients With Type 2 Diabetes. International conference

    E. Sato, T. Nagaoka, H. Yokota, A. Takahashi, A. Yoshida.

    ARVO meeting 

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    Event date： 2010.4

    Language：English   Presentation type：Poster presentation  

  • Pioglitazone Elicits Dilation of Isolated Porcine Arterioles. International conference

    T. Omae, T. Nagaoka, I. Tanano, A. Yoshida.

    ARVO meeting 

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    Event date： 2010.4

    Language：English   Presentation type：Poster presentation  

  • Association Between Diabetic Retinopathy and Flow- Mediated Vasodilation in Type 2 Diabetes. International conference

    K. Sogawa, T. Nagaoka, A. Takahashi, T. Tani, I. Tanano, T. Oumae, S. Nakabayashi, A. Ishibazawa, A. Yoshida.

    ARVO meeting 

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    Event date： 2010.4

    Language：English   Presentation type：Poster presentation  

  • Retinal Artery Response to Acute Extreme Blood Pressure Elevation With Inflation of Balloon Catheter in Cats. International conference

    S. Nakabayashi, T. Nagaoka, T. Tani, K. Sogawa, A. Yoshida.

    ARVO meeting 

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    Event date： 2010.4

    Language：English   Presentation type：Poster presentation  

  • Impaired Systemic Endothelial Function in Patients With Branch Retinal Vein Occlusion. International conference

    I.Tanano, T. Nagaoka, T. Tani, T. Omae, A. Ishibazawa, K. Sogawa, S. Nakabayashi, A. Yoshida.

    ARVO meeting 

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    Event date： 2010.4

    Language：English   Presentation type：Poster presentation  

  • Inflammation and ocular circulation International conference

    長岡泰司

    The 8th International symposium on ocular pharmacology and therapeutics 

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    Event date： 2009.12

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Venue：Rome, Italy  

  • 糖尿病網膜症に対する新たな治療戦略：薬物内服療法

    長岡泰司

    第64回日本臨床眼科学会 

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    Event date： 2009.10

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：福岡市  

  • レーザードップラー眼底血流計を用いた網膜細動脈レベルでの微小循環測定とバイオレオロジー

    長岡泰司

    第31回日本バイオレオロジー学会 

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    Event date： 2008.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：東京都  

  • Effect of Panretinal Photocoagulation on Pulsatile Ocular Blood Flow in Patients With Proliferative Diabetic Retinopathy（Invest Ophthalmol Vis Sci 2008; E-Abstract 2740） International conference

    A. Takahashi, T. Nagaoka, E. Sato, A. Yoshida

    ARVO meeting 

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    Event date： 2008.4

    Language：English   Presentation type：Poster presentation  

    Venue：Fort Laudardale, USA  

  • Acute Hyperglycemia Induces the Endothelial Dysfunction of Retinal Arteries（Invest Ophthalmol Vis Sci 2008; E-Abstract 5364） International conference

    K. Sogawa, T. Nagaoka, E. Sato, A. Takahashi, N. Izumi, A. Yoshida.

    ARVO meeting 

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    Event date： 2008.4

    Language：English   Presentation type：Poster presentation  

    Venue：Fort Laudardale, USA  

  • Change in Retinal Blood Flow Associated With Duration of Type 2 Diabetes Mellitus （Invest Ophthalmol Vis Sci 2008; E-Abstract 3509） International conference

    T. Nagaoka, A. Takahashi, H. Yokota, E. Sato, K. Sogawa, A. Yoshida

    ARVO meeting 

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    Event date： 2008.4

    Language：English   Presentation type：Poster presentation  

    Venue：Fort Laudardale, USA  

  • Reduced Compliance of the Retinal Arteriolar Circulation With Increased Serum Prorenin in Patients With Type 2 Diabetes（Invest Ophthalmol Vis Sci 2008; E-Abstract 2741） International conference

    H. Yokota, T. Nagaoka, A. Takahashi, E. Sato, A. Yoshida

    ARVO meeting 

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    Event date： 2008.4

    Language：English   Presentation type：Poster presentation  

    Venue：Fort Laudardale, USA  

  • Retinal Hemodynamics in Patients With Normal Tension Glaucoma （Invest Ophthalmol Vis Sci 2007; E-Abstract 4396） International conference

    E.Sato, A.Takahashi, M.Kawai, T.Nagaoka, A.Yoshida

    ARVO meeting 

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    Event date： 2007.5

    Language：English   Presentation type：Poster presentation  

    Venue：Fort Laudardale, USA  

  • C-reactive Protein Inhibits Endothelium-Dependent Nitric Oxide-Mediated Dilation of Isolated Porcine Retinal Arterioles. （Invest Ophthalmol Vis Sci 2007; E-Abstract 2271） International conference

    T.Nagaoka, L.Kuo, A.Yoshida, T.W. Hein

    ARVO meeting 

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    Event date： 2007.5

    Language：English   Presentation type：Poster presentation  

    Venue：Fort Laudardale, USA  

  • Effect of Topical Tafluprost on Retinal and Ocular Nerve Head Circulation in Normal Human Eyes. （Invest Ophthalmol Vis Sci 2007; E-Abstract 2280） International conference

    A.Takahashi, E.Sato, T.Nagaoka, A.Yoshida

    ARVO meeting 

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    Event date： 2007.5

    Language：English   Presentation type：Poster presentation  

    Venue：Fort Laudardale, USA  

  • Relation Between Serum Levels of Prorenin and Retinal Circulation in Patients With Type 2 Diabetes Mellitus Without Retinopathy（Invest Ophthalmol Vis Sci 2007; E-Abstract 3765） International conference

    H.Yokota, T.Nagaoka, A.Takahashi, E.Sato, A.Yoshida

    ARVO meeting 

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    Event date： 2007.5

    Language：English   Presentation type：Poster presentation  

    Venue：Fort Laudardale, USA  

  • Role of Nitric Oxide in Regulation of Retinal Blood Flow in Response to Hyperoxia in Cats（Invest Ophthalmol Vis Sci 2007; E-Abstract 871） International conference

    N. Izumi, T. Nagaoka, E. Sato, K. Sogawa, H. Kagokawa, A. Takahashi, A. Kawahara, A. Yoshida.

    ARVO meeting 

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    Event date： 2007.5

    Language：English   Presentation type：Poster presentation  

    Venue：Fort Laudardale, USA  

  • Role of VEGFR2 in the Dilation of Retinal Arterioles to Increased Lumenal Flow（Invest Ophthalmol Vis Sci 2007; E-Abstract 6041.） International conference

    R.H. Rosa, Jr., T.W. Hein, T.Nagaoka, W.Xu, Z.Yuan, L.Kuo

    ARVO meeting 

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    Event date： 2007.5

    Language：English   Presentation type：Poster presentation  

    Venue：Fort Laudardale, USA  

  • 日本眼科学会学術奨励賞受賞記念講演「生理的刺激に対する眼循環調節機構の解明-眼球加熱負荷と眼循環調節-」

    長岡泰司

    第110回日本眼科学会総会 

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    Event date： 2006.4

    Language：Japanese   Presentation type：Oral presentation (invited, special)  

    Venue：大阪市  

  • Simvastatin elicits vasodilation of retinal arterioles through nitric oxide syn thase activation and cyclic GMP signaling pathway.（Invest Ophthalmol Vis Sci 2006; E-Abstract 3765） International conference

    Nagaoka T, Hein TW, Yoshida A, Kuo L

    ARVO meeting 

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    Event date： 2006.4

    Language：English   Presentation type：Poster presentation  

    Venue：Fort Laudardale, USA  

  • Functional and molecular characterization of the endothelin system in retinal arterioles（Invest Ophthalmol Vis Sci 2006; E-Abstract 1719） International conference

    Hein TW, Yuan Z, Xu W, Pechal MI, Nagaoka T, Yoshida A, Kuo L

    ARVO meeting 

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    Event date： 2006.4

    Language：English   Presentation type：Poster presentation  

    Venue：Fort Laudardale, USA  

  • Effect of argon laser panretinal photocoagulation on choroidal circulation in the foveal region and worsening of macular edema in proliferative diabetic retinopathy. （Invest Ophthalmol Vis Sci 2006; E-Abstract 1019.） International conference

    Takahashi A, Nagaoka T, Sato E, Yoshida A

    ARVO meeting 

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    Event date： 2006.4

    Language：English   Presentation type：Poster presentation  

    Venue：Fort Laudardale, USA  

  • （シンポジウム）眼循環測定による臨床研究と今後の展望

    長岡泰司

    第59回日本臨床眼科学会 

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    Event date： 2005.10

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：札幌市  

  • （シンポジウム）生活習慣病と眼循環：動脈硬化と眼循環

    長岡泰司

    第22回日本眼循環学会 

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    Event date： 2005.7

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：兵庫県  

  • A peptide corresponding to handle region for nonproteolytic activation of prorenin inhibits retinal neovascularization in a retinopathy of prematurity model. （Invest Ophthalmol Vis Sci 2005;46:E-Abstract 4108.） International conference

    Yokota H, Takamiya A, Nagaoka T, Kitaya N, Mori F, Hikichi T, Yoshida A, Ishida Y, Suzuki F

    ARVO meeting 

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    Event date： 2005.5

    Language：English   Presentation type：Poster presentation  

    Venue：Fort Laudardale, USA  

  • Early visual acuity after photodynamic therapy and SLO microperimetry. （Invest Ophthalmol Vis Sci 2005;46:E-Abstract 306） International conference

    Ishiko S, Kagokawa H, Takamiya A, Takahashi J, Kato Y, Nagaoka T, Igarashi S, Kinouchi R, Fukui K, Yoshida A

    ARVO meeting 

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    Event date： 2005.5

    Language：English   Presentation type：Poster presentation  

    Venue：Fort Laudardale, USA  

  • Evaluation of factors on retinal circulation in patients with type 2 diabetes using a laser Doppler velocimetry (LDV) system. （Invest Ophthalmol Vis Sci 2005;46:E-Abstract 382） International conference

    Nagaoka T, Takahashi A, Izumi N, Sato E, Mori F, Kagokawa H, Kato Y, Kinouchi R, Ishiko S, Yoshida A

    ARVO meeting 

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    Event date： 2005.5

    Language：English   Presentation type：Poster presentation  

    Venue：Fort Laudardale, USA  

  • Retinal changes in Leber’s idiopathic stellate neuroretinitis using 3-dimentional optical coherence tomography. （Invest Ophthalmol Vis Sci 2005;46:E-Abstract 1541.） International conference

    Sawaki W, Ishiko S, Kinouchi R, Kato Y, Kagokawa H, Takamiya A, Takahashi J, Nagaoka T, Igarashi S, Yoshida A

    ARVO meeting 

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    Event date： 2005.5

    Language：English   Presentation type：Poster presentation  

    Venue：Fort Laudardale, USA  

  • Retinal and choroidal abnormalities in neurofibromatosis type 1 using 3-dimensional optical coherence tomography and scanning laser ophthalmoscopy. （Invest Ophthalmol Vis Sci 2005;46:E-Abstract 1544.） International conference

    Kato Y, Ishiko S, Kagokawa H, Takamiya A, Takahashi J, Nagaoka T, Kinouchi R, Igarashi S, Fukui K, Yoshida A

    ARVO meeting 

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    Event date： 2005.5

    Language：English   Presentation type：Poster presentation  

    Venue：Fort Laudardale, USA  

  • Influence to retinal blood flow by mild ischemia reperfusion in cats. （Invest Ophthalmol Vis Sci 2005;46:E-Abstract 3901） International conference

    Izumi N, Nagaoka T, Sato E, Mori F, Yoshida A

    ARVO meeting 

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    Event date： 2005.5

    Language：English   Presentation type：Poster presentation  

    Venue：Fort Laudardale, USA  

  • Effect of topical brinzolamide on retinal and choroidal circulation in normal human eyes. （Invest Ophthalmol Vis Sci 2005;46:E-Abstract 3929） International conference

    Takahashi A, Nagaoka T, Yokota H, Izumi N, Yoshida A

    ARVO meeting 

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    Event date： 2005.5

    Language：English   Presentation type：Poster presentation  

    Venue：Fort Laudardale, USA  

  • Retinal changes in juvenile X-linked retinoschisis using 3-dimentional optical coherence tomography. （Invest Ophthalmol Vis Sci 2005;46:E-Abstract 4087） International conference

    Minami Y, Ishiko S, Takai Y, Kato Y, Kagokawa A, Takamiya A, Takahashi J, Nagaoka T, Kinouchi R, Yoshida A

    ARVO meeting 

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    Event date： 2005.5

    Language：English   Presentation type：Poster presentation  

    Venue：Fort Laudardale, USA  

  • （シンポジウム）糖尿病網膜症と眼循環：レーザードップラ法を用いた眼循環測定による臨床研究

    長岡泰司

    第109回日本眼科学会総会 

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    Event date： 2005.3

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：京都市  

  • （シンポジウム）糖尿病と眼循環：２型糖尿病患者における眼循環動態の評価

    長岡泰司

    第58回日本臨床眼科学会 

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    Event date： 2004.11

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：東京都  

  • （シンポジウム）一酸化窒素(NO)の網膜循環における役割〜レーザードップラ血流計を用いた検討〜

    長岡泰司

    第21回日本眼循環学会 

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    Event date： 2004.7

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：旭川市  

  • Alteration of retinal circulation in patients with type 2 diabetes by a laser Doppler velocimetry system. （Invest Ophthalmol Vis Sci 2004;45:S4083） International conference

    Nagaoka T, Sato E, Takahashi A, Izumi N, Fukui K, Yoshida A

    ARVO meeting 

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    Event date： 2004.4

    Language：English   Presentation type：Poster presentation  

    Venue：Fort Laudardale, USA  

  • Effect of topical bunazosin hydrochloride on retinal and choroidal circulation in normal human eyes. （Invest Ophthalmol Vis Sci 2004;45:S2612） International conference

    Takahashi A, Nagaoka T, Sato E, Yokota H, Sugawara R, Yoshida A

    ARVO meeting 

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    Event date： 2004.4

    Language：English   Presentation type：Poster presentation  

    Venue：Fort Laudardale, USA  

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Awards

  • 平成25年度日本糖尿病合併症学会Young Investigator Award

    2013.9   日本糖尿病合併症学会  

    長岡泰司

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    Award type：Award from Japanese society, conference, symposium, etc.  Country：Japan

  • 日本糖尿病眼学会福田賞

    2012.12   日本糖尿病眼学会  

    長岡泰司

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    Award type：Award from Japanese society, conference, symposium, etc.  Country：Japan

  • 第２回日本網膜硝子体学会　田野Young Investigator Award

    2008.4   日本網膜硝子体学会  

    長岡泰司

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    Award type：Award from Japanese society, conference, symposium, etc.  Country：Japan

  • 日本眼科学会学術奨励賞

    2004.4   日本眼科学会  

    長岡泰司

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    Award type：Award from Japanese society, conference, symposium, etc.  Country：Japan

Research Projects

  • 網膜循環における神経—血管連関の調節機構の解明と糖尿病網膜症早期診断への臨床応用

    2013.4 - 2016.3

    （選択しない） 

  • 網膜循環における神経—血管連関の調節機構の解明と糖尿病網膜症早期診断の臨床応用

    2013.4 - 2016.3

    基盤研究(B)

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    網膜循環における神経—血管連関の調節機構の解明と糖尿病網膜症早期診断の臨床応用

  • ガス分子による新しい網膜循環調節機構の解明

    2013.4 - 2015.3

    萌芽研究

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    ガス分子による新しい網膜循環調節機構の解明

  • 2型糖尿病患者の網膜循環へのアディポサイトカインの影響と集学的な網膜症治療法確立

    2010.4 - 2013.4

    科学研究費補助金 

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    平成22年度の研究により、以下の成果を得た。

    1)ネコを用いたin vivo実験により、急性高血糖負荷により、血管内皮依存性の網膜血管拡張因子であるブラジキニンによる網膜血流増加反応が減弱することから、高血糖負荷により網膜血管内皮機能が減弱することが明らかとなった。また、高血糖負荷後に正常血糖に戻すとこのブラジキニンによる血流増加反応が改善することから、適切な血糖改善により血管内皮機能障害が改善されると推測された。さらに、活性酸素除去剤Tempolの前投与によりブラジキニンの血流増加反応が改善することから、この高血糖による血管内皮機能障害には酸化ストレス増加が関与していると推測された。

    2)2型糖尿病における網膜循環動態についてはこれまで詳しい検討がなされていなかった。我々は、網膜症のない、あるいはごく早期の網膜症を有する2型糖尿病患者を対象として、レーザードップラー眼底血流計による網膜血流量測定をおこなった。この横断研究により、網膜症のない病期ですでに網膜血流量は低下しており、軽度網膜症においても血流量は低下したままであることを明らかにした。また、網膜血流量と血中LDLDおよびクレアチニンの値は負の相関関係があり、脂質異常症および腎機能が網膜循環に影響を及ぼすと考えられた。また、網膜血流量が低値である群では、有意にHbAlcが高値であり、血糖コントロール不良により網膜循環が障害されている可能性が示唆された。

    以上の結果から、網膜症早期より網膜循環を改善させる薬剤により適切に介入することによって、その後の糖尿病網膜症の発症・進展を予防できる可能性が示唆された、平成23年度の研究により、新しい糖尿病網膜症治療法の開発につなげたいと考えている。

  • ２型糖尿病患者の網膜循環へのアディポサイトカインの影響と集学的な網膜症治療法確立

    2010.4 - 2013.3

    基盤研究(C)

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    ２型糖尿病患者の網膜循環へのアディポサイトカインの影響と集学的な網膜症治療法確立

  • 糖尿病網膜症における炎症性サイトカインの網膜循環への影響と新規治療法開発

    2009.7 - 2010.3

    独立行政法人科学技術振興機構　ＪＳＴイノベーションプラザ北海道 

  • Translational research of ocular circulation for new treatment of diabetic retinopathy

    2007.4 - 2009.3

    Grant-in-Aid for Scientific Research 

  • 眼循環のトランスレーショナルリサーチによる糖尿病網膜症の新しい治療法の開発

    2007.4 - 2009.3

    若手研究(A)

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    眼循環のトランスレーショナルリサーチによる糖尿病網膜症の新しい治療法の開発

  • 糖尿病網膜症における網膜循環および血管内皮機能異常の評価と治療法の検討

    2004.4 - 2005.3

    科学研究費補助金 

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    平成16年度に以下の研究を行い、その成果を発表することができた。

    1.ネコ眼を用いた実験

    全身麻酔下でネコの前房に針を刺入・留置し、眼灌流液のボトルを上下させることで眼圧を変動させた際の網膜循環動態について検討した。眼圧を40-70mmHgまで10mmHgに段階的に増加させ、眼球加圧負荷とした。負荷はそれぞれ5分間行った。すると、眼圧依存性に負荷終了後に一過性に網膜血流が増加した。また、眼圧60,70mmHgでは負荷終了後の網膜血流増加の際に網膜血管が拡張することも確認した。これは平成17年5月の国際学会で発表予定である。今後は、一酸化窒素、アデノシン、カリウムチャネルなどの阻害剤を用いてこれらの物質の関与を検討したい。

    2.正常人を対象とした実験

    血管内皮機能を評価することは非常に重要であるが、網膜のような細動脈レベルでの評価法は確立されていない。眼球を軽度加圧して眼圧を上昇させたあと眼血流が増加することが知られており、これを利用して新しい網膜血管内皮機能評価を試みた。この研究では、網膜血流の増加を感知して網膜細動脈が拡張することが確認され、網膜血管内皮機能評価が可能であると考えられた。さらに、新たな血管評価法として眼球加熱による眼循環反応の評価法も確立した(論文3)。

    3.患者を対象とした網膜循環動態の研究

    レーザードップラー法を用いて糖尿病患者の眼循環動態を評価すると、網膜症発症前あるいは発症早期から中心窩網膜血流と網膜血流が低下していることを報告した(論文1)。さらに、透析患者では全身循環の変動に網膜循環が大きく影響を受けること(論文2)、さらに虚血性心疾患患者では全身の動脈硬化の指標であるIntima-Media Thickness(IMT)と網膜循環パラメータが相関し、網膜細動脈レベルでの動脈硬化の評価が可能であることも明らかにした(論文4)。

    今後も研究を継続し、糖尿病患者における眼循環動態および網膜血管内皮機能異常の病態把握と解明を行う予定である。

  • 糖尿病網膜症における網膜循環および血管内皮機能異常の評価と治療法の検討

    2004.4 - 2005.3

    若手研究(B)

    　 More details

    平成16年度に以下の研究を行い、その成果を発表することができた。

    1.ネコ眼を用いた実験

    全身麻酔下でネコの前房に針を刺入・留置し、眼灌流液のボトルを上下させることで眼圧を変動させた際の網膜循環動態について検討した。眼圧を40-70mmHgまで10mmHgに段階的に増加させ、眼球加圧負荷とした。負荷はそれぞれ5分間行った。すると、眼圧依存性に負荷終了後に一過性に網膜血流が増加した。また、眼圧60,70mmHgでは負荷終了後の網膜血流増加の際に網膜血管が拡張することも確認した。これは平成17年5月の国際学会で発表予定である。今後は、一酸化窒素、アデノシン、カリウムチャネルなどの阻害剤を用いてこれらの物質の関与を検討したい。

    2.正常人を対象とした実験

    血管内皮機能を評価することは非常に重要であるが、網膜のような細動脈レベルでの評価法は確立されていない。眼球を軽度加圧して眼圧を上昇させたあと眼血流が増加することが知られており、これを利用して新しい網膜血管内皮機能評価を試みた。この研究では、網膜血流の増加を感知して網膜細動脈が拡張することが確認され、網膜血管内皮機能評価が可能であると考えられた。さらに、新たな血管評価法として眼球加熱による眼循環反応の評価法も確立した(論文3)。

    3.患者を対象とした網膜循環動態の研究

    レーザードップラー法を用いて糖尿病患者の眼循環動態を評価すると、網膜症発症前あるいは発症早期から中心窩網膜血流と網膜血流が低下していることを報告した(論文1)。さらに、透析患者では全身循環の変動に網膜循環が大きく影響を受けること(論文2)、さらに虚血性心疾患患者では全身の動脈硬化の指標であるIntima-Media Thickness(IMT)と網膜循環パラメータが相関し、網膜細動脈レベルでの動脈硬化の評価が可能であることも明らかにした(論文4)。

    今後も研究を継続し、糖尿病患者における眼循環動態および網膜血管内皮機能異常の病態把握と解明を行う予定である。

  • 網膜循環測定及び網膜血管内皮機能評価による糖尿病網膜症の病態解明に関する研究

    2002.4 - 2004.3

    科学研究費補助金 

    　 More details

    平成14から15年度にかけ、キャノン(株)と共同開発したレーザードップラー眼底血流計を用い、網膜循環動態の解明を目的として以下の基礎および臨床研究を行った。

    1)ネコを用いた基礎実験

    血流を増加させる因子である低酸素、高二酸化炭素負荷時の網膜循環調節のメカニズム解明のため、重要な血管拡張因子である一酸化窒素(NO)に着目し、NO合成酵素阻害剤をネコの硝子体に前投与すると、網膜血流増加反応はいずれの負荷においても明らかに抑制され、これらの網膜血流増加反応にNOが重要な働きをしていることを初めて明らかにした。さらに網膜血管径と血流速度の同時測定によりシェアストレス(ずり応力)の指標であるずり速度が算出でき、血管内皮機能において重要な血流増加反応を評価できることを示した(論文4および5)

    2)臨床研究

    1)健常人を対象にして寒冷刺激による血圧の一過性上昇に対して網膜細動脈の収縮により血流が保たれていることを示し網膜自己調節機構のメカニズムを解明した(論文6)。

    2)血液透析患者では透析により全身循環が大きく変動するが、透析による全身循環の変動により網膜循環動態は変動することを明らかにした(論文1)。

    3)糖尿病患者では視機能に重要な影響を与える黄斑部の脈絡膜血流が網膜症発症前からすでに低下し、黄斑浮腫を生じるとさらに低下することを明らかにした。これより現在糖尿病患者の視力障害の主因である黄斑浮腫に循環障害が関与している可能性が示唆された(論文2)。

    4)健常人を対象に、眼球を加熱したさいの眼循環動態について検討し、眼球加熱により網膜血流は増加するが、黄斑部の脈絡膜血流は反対に減少することを明らかにした(論文3)。

  • 網膜循環測定及び網膜血管内皮機能評価による糖尿病網膜症の病態解明に関する研究

    2002.4 - 2004.3

    若手研究(B)

    　 More details

    平成14から15年度にかけ、キャノン(株)と共同開発したレーザードップラー眼底血流計を用い、網膜循環動態の解明を目的として以下の基礎および臨床研究を行った。

    1)ネコを用いた基礎実験

    血流を増加させる因子である低酸素、高二酸化炭素負荷時の網膜循環調節のメカニズム解明のため、重要な血管拡張因子である一酸化窒素(NO)に着目し、NO合成酵素阻害剤をネコの硝子体に前投与すると、網膜血流増加反応はいずれの負荷においても明らかに抑制され、これらの網膜血流増加反応にNOが重要な働きをしていることを初めて明らかにした。さらに網膜血管径と血流速度の同時測定によりシェアストレス(ずり応力)の指標であるずり速度が算出でき、血管内皮機能において重要な血流増加反応を評価できることを示した(論文4および5)

    2)臨床研究

    1)健常人を対象にして寒冷刺激による血圧の一過性上昇に対して網膜細動脈の収縮により血流が保たれていることを示し網膜自己調節機構のメカニズムを解明した(論文6)。

    2)血液透析患者では透析により全身循環が大きく変動するが、透析による全身循環の変動により網膜循環動態は変動することを明らかにした(論文1)。

    3)糖尿病患者では視機能に重要な影響を与える黄斑部の脈絡膜血流が網膜症発症前からすでに低下し、黄斑浮腫を生じるとさらに低下することを明らかにした。これより現在糖尿病患者の視力障害の主因である黄斑浮腫に循環障害が関与している可能性が示唆された(論文2)。

    4)健常人を対象に、眼球を加熱したさいの眼循環動態について検討し、眼球加熱により網膜血流は増加するが、黄斑部の脈絡膜血流は反対に減少することを明らかにした(論文3)。

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Social Activities

  • 小学校での出張授業

    2015.12

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    「旭川医大における遠隔医療について」講演

  • 旭川市医師会女性医師部会　市民公開講座

    2015.7

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    「生活習慣病と目の病気」講演担当