Updated on 2025/01/09

写真a

 
OGAWA Naoki
 
Organization
Center Intellectual Property Center
External link

Degree

  • 博士(薬学) ( 2004.3   京都大学 )

Education

  • Hokkaido University   Graduate School, Division of Pharmaceutical Sciences

    - 1994.3

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    Country: Japan

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  • Hokkaido University   Faculty of Pharmaceutical Science

    1988.4 - 1992.3

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    Country: Japan

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Research History

  • Asahikawa Medical College   Associate Professor

    2018.2

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  • Asahikawa Medical College   Lecturer

    2012.4 - 2018.1

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  • Asahikawa Medical College

    2008.11 - 2012.3

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Papers

  • Probiotic-derived heptelidic acid exerts antitumor effects on extraintestinal melanoma through glyceraldehyde-3-phosphate dehydrogenase activity control Reviewed

    Shotaro Isozaki, Hiroaki Konishi, Hiroki Tanaka, Chikage Yamamura, Kentaro Moriichi, Naoki Ogawa, Mikihiro Fujiya

    BMC Microbiology   22 ( 1 )   2022.4

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    Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    Abstract

    Background

    Several microorganisms inhabit the mammalian gastrointestinal tract and are associated with the pathogenesis of various diseases, including cancer. Recent studies have indicated that several probiotics produce antitumor molecules and inhibit host tumor progression. We demonstrated that heptelidic acid (HA), a sesquiterpene lactone derived from the probiotic Aspergillus oryzae, exerts antitumor effects against pancreatic cancer in vitro and in vivo. In this study, the antitumor effects of HA against extraintestinal melanoma were assessed in vitro and in vivo.

    Results

    Sulforhodamine B (SRB) assay revealed that the growth of B16F10 cells was significantly inhibited by HA in a concentration-dependent manner. The enzymatic activity of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) decreased in proportion with the growth inhibition effect of HA. Moreover, oral HA administration significantly suppressed the growth of transplanted B16F10 tumors without any significant changes in biochemical test values. Moreover, GAPDH activity in the transplanted tumor tissues in the HA group significantly decreased compared with that in the PBS group.

    Conclusion

    This study suggests that orally administered HA was absorbed in the gastrointestinal tract, reached the cancer cells transplanted in the skin, and inhibited GAPDH activity, thereby inhibiting the growth of extraintestinal melanoma cells. Thus, this study proposes a novel system for extraintestinal tumor regulation via gut bacteria-derived bioactive mediators.

    DOI: 10.1186/s12866-022-02530-0

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    Other Link: https://link.springer.com/article/10.1186/s12866-022-02530-0/fulltext.html

  • Probiotic Aspergillus oryzae produces anti-tumor mediator and exerts anti-tumor effects in pancreatic cancer through the p38 MAPK signaling pathway Reviewed

    Hiroaki Konishi, Shotaro Isozaki, Shin Kashima, Kentaro Moriichi, Satoshi Ichikawa, Kazuki Yamamoto, Chikage Yamamura, Katsuyoshi Ando, Nobuhiro Ueno, Hiroaki Akutsu, Naoki Ogawa, Mikihiro Fujiya

    Scientific Reports   11 ( 1 )   2021.5

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    Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    Abstract

    Intake of probiotics or fermented food produced by some probiotic bacteria is believed to exert anti-tumor functions in various cancers, including pancreatic cancer, because several studies have demonstrated the anti-tumor effects of probiotic bacteria in vitro and in vivo in animal carcinogenesis models. However, the mechanisms underlying the anticancer effects of probiotics on pancreatic cancer have not been clarified. In this study, we assessed the anti-tumor effects of probiotic bacteria against pancreatic cancer cells. Among the known probiotic bacteria, Aspergillus oryzae exhibited a strong pancreatic tumor suppression effect. The culture supernatant of A. oryzae was separated by HPLC. Heptelidic acid was identified as an anti-tumor molecule derived from A. oryzae by LC–MS and NMR analysis. The anti-tumor effect of heptelidic acid was exhibited in vitro and in vivo in a xenograft model of pancreatic cancer cells. The anti-tumor effect of heptelidic acid was exerted by the p38 MAPK signaling pathway. Heptelidic acid traverses the intestinal mucosa and exerts anti-tumor effects on pancreatic cancer cells. This is a novel anti-tumor mechanism induced by beneficial bacteria against pancreatic cancer in which bacterial molecules pass through the intestinal tract, reach the extra-intestinal organs, and then induce apoptosis via an inducible signaling pathway.

    DOI: 10.1038/s41598-021-90707-4

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    Other Link: https://www.nature.com/articles/s41598-021-90707-4

  • Probiotic‑derived ferrichrome inhibits the growth of refractory pancreatic cancer cells Reviewed

    Akemi Kita, Mikihiro Fujiya, Hiroaki Konishi, Hiroki Tanaka, Shin Kashima, Takuya Iwama, Masami Ijiri, Yuki Murakami, Shuhei Takauji, Takuma Goto, Aki Sakatani, Katsuyoshi Ando, Nobuhiro Ueno, Naoki Ogawa, Toshikatsu Okumura

    International Journal of Oncology   57 ( 3 )   721 - 732   2020.7

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    Publishing type:Research paper (scientific journal)   Publisher:Spandidos Publications  

    DOI: 10.3892/ijo.2020.5096

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  • Amplification of 4'-thioDNA in the presence of 4'-thio-dTTP and 4'-thio-dCTP, and 4'-thioDNA-directed transcription in vitro and in mammalian cells. Reviewed

    Inoue N., Shionoya A., Minakawa N., Kawakami A., Ogawa N., Matsuda A.

    Journal of the American Chemical Society   129 ( 50 )   15424 - 15425   2007.12

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  • Study of modification pattern-RNAi activity relationships by using siRNAs modified with 4'-thioribonucleosides. Reviewed

    Hoshika S., Minakawa N., Shionoya A., Imada K., Ogawa N., Matsuda A.

    ChemBioChem   8 ( 17 )   2133 - 2138   2007.11

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  • In vitro simulation study of individualized chemotherapy in lung cancer.

    Li C., Gemma A., Minegishi Y., Matsuda K., Seike Y., Noro R., Shionoya A., Kawakami A., Ogawa N., Kudoh S.

    Journal of Nippon Medical School   74 ( 3 )   217 - 222   2007

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  • Epidemiology of Epstein-Barr virus, cytomegalovirus, and Kaposi's sarcoma-associated herpesvirus infections in peripheral blood leukocytes revealed by a multiplex PCR assay. Reviewed

    Nishiwaki M., Fujimuro M., Teishikata Y., Inoue H., Sasajima H., Nakaso K., Nakashima K., Sadanari H., Yamamoto T., Fujiwara Y., Ogawa N., Yokosawa H.

    Journal of Medical Virology   78 ( 12 )   1635 - 1642   2006.12

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  • Anticancer drug clustering in lung cancer based on gene expression profiles and sensitivity database. Reviewed

    Gemma A., Li C., Sugiyama Y., Matsuda K., Seike Y., Kosaihira S., Minegishi Y., Noro R., Nara M., Seike M., Yoshimura A., Shionoya A., Kawakami A., Ogawa N., Uesaka H., Kudoh S.

    BMC Cancer   30 ( 6 )   174   2006.6

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  • LPS induces stefin A3 expression in mouse primary cultured glial cells. Reviewed

    Hosoi T., Suzuki S., Okuma Y., Kawakami A., Ogawa N., Ozawa K., Nomura Y.

    Molecular Brain Research   140 ( 12 )   138 - 141   2005.10

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  • New NTP analogs: the synthesis of 4'-thioUTP and 4'-thioCTP and their utility for SELEX. Reviewed

    Kato Y., Minakawa N., Komatsu Y., Kamiya H., Ogawa N., Harashima H., Matsuda A.

    Nucleic Acids Research   33 ( 9 )   2942 - 2951   2005.5

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  • Autoregulation of the HAC1 gene is required for sustained activation of the yeast unfolded protein response. Reviewed

    Ogawa N., Mori K.

    Genes to Cells   9 ( 2 )   95 - 104   2004.2

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

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  • In vitro selection of human alpha-thrombin RNA aptamer using 4'-thioUTP and 4'-thioCTP.

    Kato Y., Minakawa N., Ogawa N., Matsuda A.

    Nucleic Acids Symposium Series   48   223 - 224   2004

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  • mRNA splicing-mediated C-terminal replacement of transcription factor Hac1p is required for efficient activation of the unfolded protein response. Reviewed

    Mori K., Ogawa N., Kawahara T., Yanagi H., Yura T.

    Proceedings of the National Academy of Sciences of the United States of America   97 ( 9 )   4660 - 4665   2000.4

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  • Palindrome with spacer of one nucleotide is characteristic of the cis-acting unfolded protein response element in Saccharomyces cerevisiae. Reviewed

    Mori K., Ogawa N., Kawahara T., Yanagi H., Yura T.

    Journal of Biological Chemistry   273 ( 16 )   9912 - 9920   1998.4

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  • cDNA cloning of a novel trypsin inhibitor with similarity to pathogenesis-related proteins, and its frequent expression in human brain cancer cells. Reviewed

    Yamakawa T., Miyata S., Ogawa N., Koshikawa N., Yasumitsu H., Kanamori T., Miyazaki K.

    Biochimica et Biophysica Acta   1395 ( 2 )   202 - 208   1998.1

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  • Identification of novel single-stranded DNA binding proteins recognizing octamer motif. Reviewed

    Ogawa N., Ariga H., Iguchi-Ariga SM

    Biochemical and biophysical research communications   200 ( 3 )   1307 - 1312   1994.5

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  • Identification of the initiation region of DNA replication in the murine immunoglobulin heavy chain gene and possible function of the octamer motif as a putative DNA replication origin in mammalian cells. Reviewed

    Iguchi-Ariga SM, Ogawa N., Ariga H.

    Biochimica et Biophysica Acta   1172 ( 1-2 )   73 - 81   1993.2

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Presentations

  • 知財活用を指向した今後の大学知財活動を考える

    尾川直樹

    広域大学ネットワーク 公開成果発表会  INPIT(独立行政法人 工業所有権情報・研修館)

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    Event date: 2014.3

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:発明会館ホール(東京 虎ノ門)  

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  • スーパー核酸技術 -核酸医薬への応用-

    尾川直樹

    第5回アライアンスプロモーション  財団法人バイオインダストリー協会

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    Event date: 2007.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京  

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  • Amplification of 4'-thioDNA and its utility as a shRNA expression system International conference

    Inoue N., Shionoya A., Mnakawa N., Ogawa N., Matsuda A.

    第5回国際核酸化学シンポジウム 

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    Event date: 2007.11

    Language:English   Presentation type:Oral presentation (general)  

    Venue:東京大学  

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  • マウス肝臓におけるラクトフェリンの脂質代謝異常予防効果

    鈴木苗, 木川博光, 村越倫明, 鈴木則行, 川上明子, 尾川直樹, 大寺基靖, 飯郷正明, 西野輔翼

    2007年日本栄養・食糧学会大会 

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    Event date: 2007.4

    Language:English   Presentation type:Poster presentation  

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  • ラクトフェリンの脂質代謝改善効果

    鈴木苗穂, 木川博光, 鈴木則行, 村越倫明, 川上明子, 尾川直樹, 大寺基靖, 飯郷正明

    日本農芸化学会2007年度大会 

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    Event date: 2007.3

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京  

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  • 歯周病原菌由来LPSの脂質代謝異常に対するラクトフェリンの効果

    木川博光, 鈴木苗穂, 小野知二, 関谷大輔, 村越倫明, 川上明子, 尾川直樹, 大寺基靖, 氏家高志, 飯郷正明

    日本農芸化学会2007年度大会  日本農芸化学会

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    Event date: 2007.3

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京  

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  • 多検体アレイを用いた新規HPVジェノタイピング法の確立

    森下 篤, 道又理恵, 尾川直樹, 小郷和彦

    第54回日本ウイルス学会学術集会 

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    Event date: 2006.11

    Language:Japanese   Presentation type:Poster presentation  

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  • 子宮病理検体において検出されるHPVジェノタイプと臨床病理学的因子の関連

    道又理恵, 尾川直樹, 石津明洋, 外丸詩野, 鈴木昭, 笠原正典, 吉木敬

    第95回日本病理学会総会 

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    Event date: 2006.4 - 2006.5

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京  

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  • ラクトフェリンの歯周病原菌Porphyromonas gingivalis 由来lipopolysaccharideに対する有効性の検討

    鈴木 苗穂, 木川 博光, 小野 知二, 関谷 大輔, 村越 倫明, 川上 明子, 尾川 直樹, 小林 宏明, 福井 朋恵, 大寺 基靖, 氏家 高志, 石川烈

    第49回春季日本歯周病学会学術大会 

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    Event date: 2006.4

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  • ラクトフェリンのヒト歯肉線維芽細胞に対する影響の解析

    鈴木 苗穂, 木川 博光, 小野 知二, 関谷 大輔, 村越 倫明, 川上 明子, 尾川 直樹, 小林 宏明, 福井 朋恵, 氏家 高志, 石川 烈

    第49回秋季日本歯周病学会学術大会 

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    Event date: 2006.4

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  • 肺癌における遺伝子発現プロファイルと感受性データベースを用いた化学療法デザイン

    小斉平聖治, 弦間昭彦, 松田久仁子, 峯岸裕司, 野呂林太郎, 奈良道哉, 岡野哲也, 篠田欣也, 吉村明修, 塩野谷亜紀, 尾川直樹, 上坂美花, 工藤翔二

    第46回日本肺癌学会総会 

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    Event date: 2005.12

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  • DNA アレイによる子宮頸部病変の HPV ジェノタイピング

    道又理恵, 尾川直樹, 石津明洋, 渡利英道, 鈴木昭, 外丸詩野, 櫻木範明, 笠原正典, 吉木. 敬

    第28回日本分子生物学会 

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    Event date: 2005.12

    Language:Japanese   Presentation type:Poster presentation  

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  • ヌクレアーゼ抵抗性を示す 4'-チオ核酸アプタマーの創製

    加藤 優佳, 南川 典昭, 尾川 直樹, 松田 彰

    第28回日本分子生物学会 

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    Event date: 2005.12

    Language:Japanese   Presentation type:Poster presentation  

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  • 産学連携による創薬を目指して -核酸誘導体技術による創薬-

    尾川直樹

    タンパク3000プロジェクトフォーラム  文部科学省

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    Event date: 2005.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

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  • DNAアレイ法を用いた子宮頸部癌症例のHPVジェノタイピング

    道又理恵, 尾川直樹, 石津明洋, 渡利英道, 鈴木明, 外丸詩野, 櫻木範明, 笠原正典, 吉木敬

    日本癌学会学術総会 

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    Event date: 2005.9

    Language:Japanese   Presentation type:Poster presentation  

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  • ヒトトロンビンに対する4'-thioRNAアプタマーの創製

    南川 典昭, 加藤 優佳, 尾川 直樹, 松田 彰

    第85回日本化学学会年会 

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    Event date: 2005.3

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • In vitro selection of human α-thrombin RNA aptamer using 4’-thioUTP and 4’-thioCTP

    加藤 優佳, 南川 典昭, 尾川 直樹, 松田 彰

    第31回核酸化学シンポジウム 

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    Event date: 2004.12

    Language:English   Presentation type:Oral presentation (general)  

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  • 小胞体シャペロンの発現制御機構

    森 和俊, 岡田徹也, 吉田秀郎, 土師京介, 尾川直樹, 柳 秀樹, 由良 隆

    第22回日本分子生物学会年会 

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    Event date: 1999.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

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  • 小胞体から細胞核への情報伝達機構

    森 和俊, 尾川直樹, 川原哲史, 柳 秀樹, 由良 隆

    第21回日本分子生物学会年会 

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    Event date: 1998.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

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Industrial property rights

  • ポリリン酸亜鉛及びその製造方法

    藤谷 幹浩, 小西 弘晃, 尾川 直樹, 池田 幸平, 伊藤 早織, 宮原 順一

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    Application no:PCT/JP2023/038803  Date applied:2023.10

    Announcement no:WO/2024/090537  Date announced:2024.5

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  • ポリリン酸亜鉛を含む医薬組成物

    藤谷幹浩, 小西弘晃, 尾川直樹, 池田幸平, 伊藤早織, 宮原順一

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    Application no:PCT/JP2023/038804  Date applied:2023.10

    Announcement no:WO/2024/090538  Date announced:2024.2

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  • 血小板凝集剤

    藤谷幹浩, 小西弘晃, 田中宏樹, 磯崎翔太郎, 大町佳宏, 尾川直樹

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    Application no:PCT/JP2021/000261  Date applied:2021.1

    Announcement no:WO/2021/141066  Date announced:2021.7

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  • ヒトパピローマウイルスを検出するためのプライマーセット及びプローブ

    森下 篤, 宮川 功, 小郷 和彦, 川上 明子, 尾川 直樹

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    Applicant:倉敷紡績株式会社, 株式会社ジェネティックラボ

    Application no:PCT/JP2008/063906  Date applied:2008.8

    Announcement no:WO/2009/020079  Date announced:2009.2

    Country of applicant:International (PCT) application  

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  • shRNA 発現用DNA カセット

    松田彰, 南川典昭, 塩野谷亜紀, 尾川直樹

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    Applicant:北海道大学, 株式会社ジェネティックラボ

    Application no:特願2007-298097  Date applied:2007.11

    Announcement no:特開2009-118804  Date announced:2009.6

    Country of applicant:Domestic  

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  • DNA/RNAキメラオリゴヌクレオチド

    加藤 優佳, 尾川 直樹, 南川 典昭, 松田 彰

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    Applicant:株式会社ジェネティックラボ

    Application no:特願2006-311103  Date applied:2006.11

    Announcement no:特開2008-125374  Date announced:2008.6

    Country of applicant:Domestic  

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  • マルチプレックスPCRを用いたヘルペスウイルス遺伝子検出法

    藤室 雅弘, 西脇 森衛, 尾川 直樹, 横沢 英良

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    Applicant:北海道大学, 株式会社ジェネティックラボ

    Application no:特願2005-040607  Date applied:2005.2

    Announcement no:特開2006-223180  Date announced:2006.8

    Country of applicant:Domestic  

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  • 新規クニッツ型プロテアーゼインヒビター

    加藤 穣, 尾川 直樹, 磯貝 隆夫

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    Applicant:持田製薬株式会社

    Application no:特願2002-038074  Date applied:2002.2

    Announcement no:特開2003-235574  Date announced:2003.8

    Country of applicant:Domestic  

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  • メルトリン

    藤澤 淳子, 山川 徹, 白川 嘉門, 水島 千登勢, 尾川 直樹

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    Applicant:持田製薬株式会社

    Application no:PCT/JP1996/003017  Date applied:1996.10

    Announcement no:WO1997/031109  Date announced:1997.8

    Patent/Registration no:特許第4118336号  Date registered:2008.5 

    Country of applicant:International (PCT) application  

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