Updated on 2026/04/09

写真a

 
MIYAZONO Sadaharu
 
Organization
Center Institutional Research Office
External link

Degree

  • 理学博士 ( 大阪大学 )

Research Interests

  • 感覚生理

  • 「次世代脳」プロジェクト

  • 炎症

  • 記憶

  • 情動

  • 天敵

  • 視覚

  • 包括脳ネットワーク

  • 分子生理学

  • 電気生理学

  • 嗅覚

  • 脳科学

  • アルツハイマー病

  • グリア細胞

  • 神経科学

  • 脳機能

Research Areas

  • Life Science / Basic brain sciences

  • Life Science / Animals: biochemistry, physiology, behavioral science

Education

  • 大阪大学大学院   生命機能研究科

    - 2008

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Research History

  • Asahikawa Medical College   Assistant Professor

    2011

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  • Harvard Medical School, Postdoctoral fellow

    2008 - 2011

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Professional Memberships

Committee Memberships

  • 日本味と匂学会   評議員  

    2016   

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    Committee type:Academic society

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  • Frontiers in Molecular Neuroscience   Review Editor  

    2016   

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    Committee type:Academic society

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Papers

  • Oregano leaf odor regulates sodium chloride consumption in mice Reviewed

    Kazumi Osada, Nanako Akiyama, Akira Hosono, Motoko Ohata, Issei Yokoyama, Sadaharu Miyazono, Michio Komai

    Bioscience, Biotechnology, and Biochemistry   89 ( 5 )   776 - 786   2025.5

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    Publishing type:Research paper (scientific journal)   Publisher:Oxford University Press (OUP)  

    Abstract

    This study explores how the odor of oregano and its active component, carvacrol, influence salt preference in mice. Using a 2-bottle choice test (distilled water vs 0.15 m NaCl), 66 C57BL/6J mice were exposed to oregano odor. Female mice showed a significant reduction in saline intake with oregano or carvacrol exposure, while the effect was lower in males. Carvacrol was identified in dried oregano using gas chromatography–mass spectrometry (GC–MS) with headspace–solid-phase microextraction (HS–SPME). Neurologically, oregano odor increased c-Fos immunoreactivity in the ventral bed nucleus of the stria terminalis, a region regulating salt appetite. These results suggest that oregano odor decreases salt preference, partly due to carvacrol, which stimulates brain areas controlling salt appetite. This study highlights the role of olfactory cues in modulating dietary behavior and suggests potential applications for managing salt consumption in health contexts.

    DOI: 10.1093/bbb/zbaf014

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  • Changes in gaseous concentration of alkylpyrazine analogs affect mouse avoidance behavior. Reviewed International journal

    Kazumi Osada, Sadaharu Miyazono, Motoko Ohata, Tomohiro Noguchi, Makoto Kashiwayanagi

    Bioscience, biotechnology, and biochemistry   85 ( 12 )   2343 - 2351   2021.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    The Y-maze is often used to detect subtle differences between similar odor sources; however, very little information is available about the dispersion of odor plumes in the Y-maze. Using headspace solid-phase microextraction (HS-SPME) in conjunction with a GC-MS system, we quantified alkylpyrazine analogs in the Y-maze. Rapid extraction of volatile compounds in the vapor phase enabled accurate quantitative analysis of temporal changes in the levels of gaseous alkylpyrazine analogs at several locations in the Y-maze. We conducted behavioral tests of mice in response to these volatiles and identified a positive relationship between the rate of increase in gaseous concentration and the induced avoidance rate. Our results demonstrate that the Y-maze is a simple but reliable apparatus for behavioral studies of olfaction. Our findings show that the HS-SPME fast extraction method could quantify how gaseous concentrations of alkylpyrazine analogs change over time, and that temporal increases in alkylpyrazine concentration were correlated with induction of aversive behavior in mice.

    DOI: 10.1093/bbb/zbab178

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  • Thallium-201 Imaging in Intact Olfactory Sensory Neurons with Reduced Pre-Synaptic Inhibition In Vivo. Reviewed International journal

    Hideaki Shiga, Hiroshi Wakabayashi, Kohshin Washiyama, Tomohiro Noguchi, Tomo Hiromasa, Sadaharu Miyazono, Masami Kumai, Kazuma Ogawa, Junichi Taki, Seigo Kinuya, Takaki Miwa

    Molecular neurobiology   57 ( 12 )   4989 - 4999   2020.8

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    In this study, we determined whether the 201Tl (thallium-201)-based olfactory imaging is affected if olfactory sensory neurons received reduced pre-synaptic inhibition signals from dopaminergic interneurons in the olfactory bulb in vivo. The thallium-201 migration rate to the olfactory bulb and the number of action potentials of olfactory sensory neurons were assessed 3 h following left side nasal administration of rotenone, a mitochondrial respiratory chain complex I inhibitor that decreases the number of dopaminergic interneurons without damaging the olfactory sensory neurons in the olfactory bulb, in mice (6-7 animals per group). The migration rate of thallium-201 to the olfactory bulb was significantly increased following intranasal administration of thallium-201 and rotenone (10 μg rotenone, p = 0.0012; 20 μg rotenone, p = 0.0012), compared with that in control mice. The number of action potentials was significantly reduced in the olfactory sensory neurons in the rotenone treated side of 20 μg rotenone-treated mice, compared with that in control mice (p = 0.0029). The migration rate of thallium-201 to the olfactory bulb assessed with SPECT-CT was significantly increased in rats 24 h after the left intranasal administration of thallium-201 and 100 μg rotenone, compared with that in control rats (p = 0.008, 5 rats per group). Our results suggest that thallium-201 migration to the olfactory bulb is increased in intact olfactory sensory neurons with reduced pre-synaptic inhibition from dopaminergic interneurons in olfactory bulb glomeruli.

    DOI: 10.1007/s12035-020-02078-y

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  • Stimulus dynamics-dependent information transfer of olfactory and vomeronasal sensory neurons in mice. Reviewed International journal

    Noguchi T, Miyazono S, Kashiwayanagi M

    Neuroscience   400   48 - 61   2019.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    The parallel processing of chemical signals by the main olfactory system and the vomeronasal system has been known to control animal behavior. The physiological significance of peripheral parallel pathways consisting of olfactory sensory neurons and vomeronasal sensory neurons is not well understood. Here, we show complementary characteristics of the information transfer of the olfactory sensory neurons and vomeronasal sensory neurons. A difference in excitability between the sensory neurons was revealed by patch-clamp experiments. The olfactory and vomeronasal sensory neurons showed phasic and tonic firing, respectively. Intrinsic channel kinetics determining firing patterns was demonstrated by a Hodgkin-Huxley-style computation. Our estimation of the information carried by action potentials during one cycle of sinusoidal stimulation with variable durations revealed distinct characteristics of information transfer between the sensory neurons. Phasic firing of the olfactory sensory neurons was suitable to carry information about rapid changes in a shorter cycle (<200 ms). In contrast, tonic firing of the vomeronasal sensory neurons was able to convey information about smaller stimuli changing slowly with longer cycles (>500 ms). Thus, the parallel pathways of the two types of sensory neurons can convey information about a wide range of dynamic stimuli. A combination of complementary characteristics of olfactory information transfer may enhance the synergy of the interaction between the main olfactory system and the vomeronasal system.

    DOI: 10.1016/j.neuroscience.2018.12.043

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  • Oxytocin receptor signaling contributes to olfactory avoidance behavior induced by an unpleasant odorant. Reviewed International journal

    Osada K, Ohta T, Takai R, Miyazono S, Kashiwayanagi M, Hidema S, Nishimori K

    Biology open   7 ( 9 )   2018.9

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    Oxytocin (OXT) and its receptor (OXTR) regulate reproductive physiology (i.e. parturition and lactation), sociosexual behavior, learned patterns of behavior and olfactory behavior in social contexts. To characterize the function of OXTR in basic olfactory behavior, the present study compared the behavioral responses of homozygous, heterozygous and wild-type mice when these mice were confronted with an unpleasant odorant (butyric acid) in a custom-made Y-maze in the absence of a social context. Wild-type mice avoided the first encounter with the butyric acid odorant, whereas homozygous and heterozygous mice did not. However, both heterozygous and wild-type mice habituated when confronted with the butyric odorant again on the following 2 days. By contrast, homozygous mice failed to habituate and instead avoided the location of the odorant for at least 3 days. These data suggest that homozygous and heterozygous mice display abnormal olfactory responses to the presentation of an unpleasant odorant. Our studies demonstrate that OXTR plays a critical role in regulating olfactory behavior in the absence of a social context.

    DOI: 10.1242/bio.029140

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  • Etizolam attenuates the reduction in cutaneous temperature induced in mice by exposure to synthetic predator odor Reviewed

    Sadaharu Miyazono, Kaede Hasegawa, Seri Miyazaki, Hikari Sakakima, Shun Konno, Saori Meguro, Hitoshi Sasajima, Tomohiro Noguchi, Kazumi Osada, Makoto Kashiwayanagi

    European Journal of Pharmacology   824   157 - 162   2018.4

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier B.V.  

    DOI: 10.1016/j.ejphar.2018.02.015

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  • Pyrazine analogues from wolf urine induced unlearned fear in rats Reviewed

    Makoto Kashiwayanagi, Sadaharu Miyazono, Kazumi Osada

    Heliyon   3 ( 8 )   e00391   2017.8

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier Ltd  

    DOI: 10.1016/j.heliyon.2017.e00391

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  • Structure-Activity Relationships of Alkylpyrazine Analogs and Fear-Associated Behaviors in Mice Reviewed

    Kazumi Osada, Sadaharu Miyazono, Makoto Kashiwayanagi

    JOURNAL OF CHEMICAL ECOLOGY   43 ( 3 )   263 - 272   2017.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10886-017-0822-3

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  • Intranasal Administration of Rotenone to Mice Induces Dopaminergic Neurite Degeneration of Dopaminergic Neurons in the Substantia Nigra Reviewed

    Hitoshi Sasajima, Sadaharu Miyazono, Tomohiro Noguchi, Makoto Kashiwayanagi

    BIOLOGICAL & PHARMACEUTICAL BULLETIN   40 ( 1 )   108 - 112   2017.1

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    DOI: 10.1248/bpb.b16-00654

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  • Intranasal administration of rotenone in mice attenuated olfactory functions through the lesion of dopaminergic neurons in the olfactory bulb Reviewed

    Hitoshi Sasajima, Sadaharu Miyazono, Tomohiro Noguchi, Makoto Kashiwayanagi

    NEUROTOXICOLOGY   51   106 - 115   2015.12

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    DOI: 10.1016/j.neuro.2015.10.006

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  • The scent of wolves: pyrazine analogs induce avoidance and vigilance behaviors in prey Reviewed

    Kazumi Osada, Sadaharu Miyazono, Makoto Kashiwayanagi

    FRONTIERS IN NEUROSCIENCE   9   363   2015.10

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    DOI: 10.3389/fnins.2015.00363

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  • RDH13L, an Enzyme Responsible for the Aldehyde-Alcohol Redox Coupling Reaction (AL-OL Coupling Reaction) to Supply 11-cis Retinal in the Carp Cone Retinoid Cycle Reviewed

    Shinya Sato, Sadaharu Miyazono, Shuji Tachibanaki, Satoru Kawamura

    JOURNAL OF BIOLOGICAL CHEMISTRY   290 ( 5 )   2983 - 2992   2015.1

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    DOI: 10.1074/jbc.M114.629162

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  • Impaired mastication reduced newly generated neurons at the accessory olfactory bulb and pheromonal responses in mice Reviewed

    Chizuru Utsugi, Sadaharu Miyazono, Kazumi Osada, Mitsuyoshi Matsuda, Makoto Kashiwayanagi

    ARCHIVES OF ORAL BIOLOGY   59 ( 12 )   1272 - 1278   2014.12

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    DOI: 10.1016/j.archoralbio.2014.07.018

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  • Pyrazine analogs are active components of wolf urine that induce avoidance and fear-related behaviors in deer Reviewed

    Kazumi Osada, Sadaharu Miyazono, Makoto Kashiwayanagi

    FRONTIERS IN BEHAVIORAL NEUROSCIENCE   8   276   2014.8

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    DOI: 10.3389/fnbeh.2014.00276

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  • Similar rate of information transfer on stimulus intensity in accessory and main olfactory bulb output neurons Reviewed

    Tomohiro Noguchi, Hitoshi Sasajima, Sadaharu Miyazono, Makoto Kashiwayanagi

    NEUROSCIENCE LETTERS   576   56 - 61   2014.7

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    DOI: 10.1016/j.neulet.2014.05.058

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  • Hard-Diet Feeding Recovers Neurogenesis in the Subventricular Zone and Olfactory Functions of Mice Impaired by Soft-Diet Feeding Reviewed

    Chizuru Utsugi, Sadaharu Miyazono, Kazumi Osada, Hitoshi Sasajima, Tomohiro Noguchi, Mitsuyoshi Matsuda, Makoto Kashiwayanagi

    PLOS ONE   9 ( 5 )   e97309   2014.5

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    DOI: 10.1371/journal.pone.0097309

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  • Modulating the phototransduction cascade with small molecules Reviewed

    Isayama Tomoki, Wu Junchao, Miyazono Sadaharu, Lee Vanessa, Levine Emily, Makino Elina, Zimmerman Anita, Makino Clint

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   54 ( 15 )   2013.6

  • ロテノンの経鼻投与によるマウス嗅覚機能の低下

    柏柳 誠, 笹島 仁, 宮園 貞治, 野口 智弘

    日本鼻科学会会誌   51 ( 3 )   429 - 429   2012.9

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    Language:Japanese   Publisher:(一社)日本鼻科学会  

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  • Vitamin A activates rhodopsin and sensitizes it to ultraviolet light Reviewed

    Sadaharu Miyazono, Tomoki Isayama, Francois C. Delori, Clint L. Makino

    VISUAL NEUROSCIENCE   28 ( 6 )   485 - 497   2011.11

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    DOI: 10.1017/S0952523811000423

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  • Do vertebrate rhodopsins contain an allosteric binding site(s) for retinoids? Reviewed

    Tomoki Isayama, Sadaharu Miyazono, Tetsuji Okada, Masahiro Kono, Rosalie Crouch, Anita Zimmerman, Clint Makino

    FASEB JOURNAL   24   2010.4

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  • Highly efficient retinal metabolism in cones Reviewed

    Sadaharu Miyazono, Yoshie Shimauchi-Matsukawa, Shuji Tachibanaki, Satoru Kawamura

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   105 ( 41 )   16051 - 16056   2008.10

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    DOI: 10.1073/pnas.0806593105

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  • Reduction of all-trans retinal to retinol in rods and cones Reviewed

    Sadaharu Miyazono, Yoshie Matsukawa, Shuji Tachibanaki, Satoru Kawamura

    ZOOLOGICAL SCIENCE   23 ( 12 )   1199 - 1199   2006.12

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  • Function of fatty acid-binding protein (FBP) in the Drosophila retina Reviewed

    Koichi Ozaki, Sadaharu Miyazono, Noboru Gombi, Daichi Ohno

    ZOOLOGICAL SCIENCE   23 ( 12 )   1199 - 1199   2006.12

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  • Metabolic pathways of retinoid in the pigment cells of Drosophila retina Reviewed

    Koichi Ozaki, Sadaharu Miyazono, Noboru Gombi, Daichi Ohno

    COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY   145 ( 3-4 )   420 - 420   2006.11

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  • Functional analysis of the proteins localized on pigment granules in the Drosophila retinal pigment cells Reviewed

    Sadaharu Miyazono, Satoru Kawamura, Koichi Ozaki

    ZOOLOGICAL SCIENCE   22 ( 12 )   1474 - 1474   2005.12

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MISC

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Presentations

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Awards

  • B.B.B.論文賞

    2026   日本農芸化学会  

    Osada K., Akiyama N., Hosono A., Ohata M., Yokoyama I., Miyazono S., Komai M.

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  • F1000Prime

    2012   F1000 Faculty  

    Miyazono S, Isayama T, Delori FC, Makino CL

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  • F1000Prime

    2009   F1000 Faculty  

    Miyazono S, Shimauchi-Matsukawa Y, Tachibanaki S, Kawamura S

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  • 楠本賞

    2003   大阪大学  

    宮園 貞治

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Research Projects

  • 中枢性嗅覚障害における嗅球ドパミン神経細胞死と匂い嗅ぎ呼吸調節の因果関係

    Grant number:23K08904  2023.4 - 2026.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    野口 智弘, 志賀 英明, 佐藤 元, 笹島 仁, 宮園 貞治

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    Grant amount:\4,680,000 ( Direct Cost: \3,600,000 、 Indirect Cost:\1,080,000 )

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  • 幼少期ストレスによる精神・身体変容の性差を生み出す脳内神経基盤の包括的理解

    Grant number:20K06734  2020.4 - 2023.3

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    宮園 貞治

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    Grant amount:\4,420,000 ( Direct Cost: \3,400,000 、 Indirect Cost:\1,020,000 )

    幼少期に虐待やネグレクト(育児放棄)などの大きなストレスを経験すると、将来、うつ病や心的外傷後ストレス症候群(Post Traumatic Stress Disorder;PTSD)などの精神疾患の発症率が高くなるだけでなく、心臓病や肺がんといった身体の異常の発症率も上昇すると言われている。このような将来的に精神だけでなく身体までにも引き起こされる異常は、成長過程における脳内神経回路の不可逆的な変容が長期にわたって継続したためと考えられるが、その機序の詳細は明らかではない。本研究では、幼少期に母仔分離ストレスを継続的に経験したマウスを用いて、幼少期ストレスによって精神と身体の両方に異常を引き起こす脳内神経回路の変容機序の解明を目的とし、その性差についても検討することとした。
    令和2年度は次のような成果を得た。嗅覚による先天的恐怖反応試験時における、内分泌性のストレス耐性の指標である血中コルチコステロン濃度を調べた。その結果、幼少期ストレスによって、オスでは先天的恐怖刺激がなくてもコルチコステロン濃度が高レベルで維持され、試験時にはそれ以上の大きな上昇は見られなかった。一方、メスでは通常とは異なる変化は見られなかった。以上のことから、オスではメスに比べて、幼少期ストレスが継続的な内分泌性の異常をもたらし、それが身体に悪影響を与え続けることが示唆された。今後、この機序の解明に取り組んでいくと共に、内分泌性だけでなく自律神経性のストレス耐性についても検討を行っていく予定である。

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  • Spatiotemporal control of synapse formation on dopaminergic interneurons in mouse olfactory bulbs during recovery from olfactory impairments.

    Grant number:20K09683  2020.4 - 2023.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

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    Authorship:Coinvestigator(s) 

    Grant amount:\4,030,000 ( Direct Cost: \3,100,000 、 Indirect Cost:\930,000 )

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  • アルツハイマー病最初期における嗅覚障害を引き起こす脳内異常の予防

    2018

    旭川医科大学  抗加齢医学プロジェクト 

    宮園貞治

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    Authorship:Principal investigator  Grant type:Competitive

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  • 幼少期ストレスによる神経回路変容が引き起こす心身異常の総合的理解

    2017 - 2021

    文部科学省  科学研究費補助金(基盤研究(C)) 

    宮園貞治

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  • Elucidation of neural and molecular mechanisms regulating brain function by oral sensation

    Grant number:15K07962  2015.4 - 2019.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    Kashiwayanagi Makoto

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    Grant amount:\4,810,000 ( Direct Cost: \3,700,000 、 Indirect Cost:\1,110,000 )

    In this study, the neural pathway where oral sensory information is transmitted to the substantia nigra parenchyma were investigated when mouse ingested chow. For example, neurons at the cerebral cortex somatosensory area, lateral reticular body, pontine nucleus, trigeminal spinal cord tract were excited. In addition, at the olfactory bulb where nerve cells newly generated in the subventricular zone migrated, the activity of interneurons such as the change of GABA release was affected. These results directly indicate that the decrease in migration of newly generated cells to the olfactory bulb associated with the decrease in neurogenesis in the subventricular zone of mice fed a powder diet affects the mitral cell, output cells of the olfactory bulb, activity.

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  • Neural circuits mediating behavioral and physiological changes in fear response to odor stimulus

    Grant number:15K18573  2015 - 2017

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

    MIYAZONO Sadaharu

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4,290,000 ( Direct Cost: \3,300,000 、 Indirect Cost:\990,000 )

    For animal survival, it is important to respond appropriately to danger by feeling fear. When mice sniff the predator odor, they show behavioral, autonomic, and endocrine fear responses. In this study, we attempted to understand the induction and control mechanism of the fear reactions, using pyrazine compounds involved in wolf urine we identified previously. The pyrazine odor information simultaneously induced a set of fear reactions by activating neural circuits in both the main olfactory and vomeronasal systems in the brain. Also, the odor information was suggested to cause the region-specific activation in the bed nucleus of the stria terminalis and the anterior hypothalamic nucleus in these olfactory systems.

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  • 本能的に恐怖を感じる匂いを応用した野生動物に対する忌避剤の開発

    2015

    秋山記念生命科学振興財団  研究助成(奨励) 

    宮園貞治

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  • においに対する恐怖反応を制御する脳内神経回路の解明とその応用

    2014

    ノーステック財団研究開発助成事業  若手研究人材・ネットワーク育成補助金 

    宮園貞治

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  • 新規抗不安薬の恐怖情動に対する定量的評価系の確立

    2013 - 2014

    旭川医科大学  独創性のある生命科学研究 

    宮園貞治

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  • Olfactory dysfunction in early Alzheimer's disease

    Grant number:24770064  2012 - 2014

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

    MIYAZONO Sadaharu

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4,550,000 ( Direct Cost: \3,500,000 、 Indirect Cost:\1,050,000 )

    Alzheimer's disease (AD) is a neurodegenerative disorder associated with the progressive impairment of cognition. The olfactory dysfunction occurs early in AD. However, the mechanism behind the dysfunction remains largely unknown. In this study, we tried to understand how Amyloid-β peptide (Aβ) induces the olfactory dysfunction, using transgenic mice deleting amyloid precursor protein binding protein, X11, that regulates amyloidogenesis. The young KO mice, that showed normal olfaction, have the higher level of soluble Aβ in the olfactory bulb (OB) than the wild-type mice. The KO mice accumulated the insoluble Aβ abundantly by aging. The Aβ aggregation might reduce an activity in the neural circuit of the OB and induce the olfactory dysfunction. Additionally, donepezil, an acetylcholinesterase inhibitor, prevented the Aβ aggregation in the OB, and improved the impaired olfactory function.

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  • 薬物の鼻腔内投与による脳内神経機能の制御

    2010 - 2011

    旭川医科大学  独創性のある生命科学研究 

    宮園貞治

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Teaching Experience

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Social Activities

  • 実験動物学

    2025

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  • 体験型サイエンスイベント「わくわくサイエンス」

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