Language：English   Publishing type：Research paper (scientific journal)  

Paternally expressed gene 10 (PEG10) is expressed primarily in the placenta; its expression is extremely low or absent in normal tissues but up-regulated in various cancers, indicating that PEG10 is a potential target for cancer immunotherapy. However, the expression and role of PEG10 in head and neck squamous cell carcinoma (HNSCC) and the immunogenicity of possible PEG10-derived T-cell epitopes remain unclear. In the present study, we show that PEG10 is expressed in HNSCC, and its high expression is associated with poor patient survival. Suppression of PEG10 expression attenuated the proliferation, migration, and invasion of HNSCC cells and altered their gene expression profiles. We also identified a PEG10-derived peptide epitope (PEG10216-232) capable of eliciting antigen-specific and promiscuous human leukocyte antigen (HLA)-DR-restricted helper T lymphocyte (HTL) responses. Notably, PEG10-specific HTLs exerted direct cytotoxicity against PEG10-positive HNSCC cells in an HLA-DR-restricted manner. Moreover, precursor T cells that react to PEG10216-232 peptide were detected in HNSCC patients. These results indicate that PEG10 plays an important role in HNSCC tumorigenesis and qualifies as an immunotherapeutic target against HNSCC. The helper epitope peptide of PEG10 could effectively stimulate antigen-specific HTLs and induce anti-tumor responses against PEG10-positive cancers, including HNSCC.

DOI： 10.1007/s00262-025-04110-3

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Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

Salivary duct carcinoma (SDC) is a high-grade salivary gland cancer with a poor prognosis. Although therapeutic antibodies capable of targeting several proteins expressed in SDC, such as epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), have been developed, the stability of these antigens during recurrence remains unknown. Herein, we report a case of SDC in the submandibular gland wherein EGFR loss was pathologically confirmed after EGFR-targeted therapy. A 53-year-old man with a right submandibular mass underwent primary tumor resection with ipsilateral radical neck dissection and was diagnosed with SDC along with high EGFR and HER2 expression. Multiple pulmonary metastases appeared five months after the surgery, and the patient received 12 cycles of chemotherapy with paclitaxel and cetuximab. Although most metastatic nodules disappeared with the chemotherapy, a single nodule enlarged 15 months after the treatment. The resection of the pulmonary nodule pathologically confirmed the metastasis of SDC, wherein EGFR expression was downregulated. The patient has remained in remission for seven years after pulmonary metastasectomy without any additional treatment. As selective pressures caused by molecule-targeted therapies may downregulate the expression of the corresponding molecules, pathological examination using the latest tissue samples is ideal for elucidating the biological features of recurrent SDC. Our findings provide valuable insights for developing effective strategies for the treatment of cases with SDC recurrence post molecule-targeted therapy.

DOI： 10.7759/cureus.83763

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Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

BACKGROUND: The efficacy of anti-PD-1 and EGFR therapies for head and neck squamous cell carcinoma (HNSCC) can be predicted using various markers; however, the stability of these markers remains unclear. METHODS: In this retrospective study, laboratory findings and tissue expression of PD-L1, PD-L2, and EGFR were analyzed in 79 paired naive and recurrent HNSCC tumors. Laboratory findings were also analyzed in nonrecurrent patients using a propensity score-matched analysis. PD-L1 and PD-L2 expression levels were assessed using tumor proportion score (TPS) and combined positive score (CPS), whereas EGFR was evaluated using the H-score. RESULTS: White blood cell, neutrophil, lymphocyte, and monocyte counts and lymphocyte-monocyte ratios were significantly lower in the patients after the first-line treatment regardless of recurrence. PD-L1, PD-L2, and EGFR expression changed in 30%-40% of tumor pairs. Immune but not tumoral PD-L1 positivity rates were significantly higher in the patients with early recurrence. CONCLUSIONS: The expression of immune checkpoints including PD-L1 in naive tumors does not reflect those in recurrent tumors. Increasing PD-L1 expression in immune cells may cause early recurrence of HNSCC.

DOI： 10.1002/hed.28151

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

Abstract

In this study, the critical role of the epipharynx in managing long-term coronavirus disease 2019 (COVID-19), and in particular, how residual SARS-CoV-2 RNA affects signalling pathways in the epipharynx were investigated via spatial gene expression analysis (Visium HD). Moreover, we hypothesize that epipharyngeal abrasive therapy (EAT) targeting the epipharynx could improve long COVID symptoms by modulating local inflammation and gene expression. We conducted a comparative analysis of the gene expression profiles of three patients with long COVID and two control individuals without COVID-19. Residual SARS-CoV-2 RNA was detected in the epipharynx of patients with long COVID, along with the activation of signalling pathways in epithelial and immune cells. After EAT, the viral RNA was either completely cleared or significantly reduced. T-cell receptor signalling pathways were suppressed; the levels of proinflammatory cytokines, such as interleukin-6 and tumour necrosis factor-α, were reduced; and excessive antibody production was mitigated. Histology showed that EAT effectively eliminated the inflamed, dysfunctional ciliated epithelium. This study clarifies that SARS-CoV-2 has long-term effects on the immune response in the epipharynx, emphasizing the need to focus on chronic epipharyngitis as a potential cause of long COVID. Furthermore, EAT may offer a promising approach to alleviating persistent long COVID symptoms.

DOI： 10.1038/s41598-025-92908-7

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Other Link： https://www.nature.com/articles/s41598-025-92908-7

Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.bjorl.2024.101539

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Cases of advanced eyelid squamous cell carcinoma (ESCC) are rare because most patients with eyelid cancer visit hospitals when the cancer is in relatively early stages. However, utill date, no study has recommended the most suitable treatment method for unresectable advanced skin squamous cell carcinoma (SSCC). Herein, we report a case of unresectable ESCC that invaded the orbital contents and paranasal sinuses, and was treated with moderate-dose cisplatin and docetaxel chemotherapy with radiation therapy. Our treatment method may be a feasible option for patients with advanced SSCC.

DOI： 10.7759/cureus.80984

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Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

DOI： 10.7759/cureus.78590

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Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.anl.2024.12.008

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Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：MDPI AG  

Background/Objectives: The OTOF gene is reported to be the causative gene for non-syndromic recessive sensorineural hearing loss and auditory neuropathy spectrum disorder. About 300 variants have been reported, but there have been no reports to date on copy gain variants. Methods: We identified a copy gain variant in the OTOF gene through short-read next-generation sequencing analysis from one patient with auditory neuropathy. We also performed long-read next-generation sequencing analysis using the Oxford Nanopore Technologies adaptive sampling procedure. Results: The four-year-old male carried a duplication of chr2: 26,477,852 to 26,483,106 (a 5254-base duplication including exon 14 to exon 18 of the OTOF gene NM_001287489) and a c.5385C>A single nucleotide variant. We also confirmed that these two variants were located in the trans configuration based on haplotype phasing results using the long-read next-generation sequencing data. Conclusions: This is the first report of an auditory neuropathy patient with a large duplication variant in the OTOF gene. The identified variants were novel, but based on the clinical phenotype of the patient, these variants seem to be the genetic cause of this patient’s phenotype. Oxford Nanopore Technologies adaptive sampling is a powerful tool for the analysis of structural variants (particularly for determining the breakpoint and direction) and haplotype phasing.

DOI： 10.3390/genes16020116

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

DOI： 10.7759/cureus.76342

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DOI： 10.1038/s41598-024-57415-1

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Language：Japanese   Publishing type：Research paper (scientific journal)  

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：American Association for Cancer Research (AACR)  

Abstract

Adoptive cell therapy (ACT) using retrovirally transduced T cells represents a promising strategy for enhancing antitumor responses. When used with TriVax, a peptide vaccination strategy, this approach synergistically expands antigen-specific cell populations. STAT5 plays a vital role as a transcription factor in regulating T-cell proliferation and their differentiation into effector and memory T cells. We aimed to explore the combination therapy using CD8 T cells engineered to express constitutively active STAT5 (CA-STAT5) with vaccines. CD8 T cells were transduced with a retrovirus (RV) encoding the mouse gp100 T-cell receptor (TCR). In certain treatment groups, cells were also co-transduced with RV encoding CA-STAT5. We assessed transduction efficiency and functional activity through flow cytometry and various functional assays. B16F10 tumor-bearing mice were treated with ACT using RV-transduced CD8 T cells and subsequently vaccinated with TriVax. We demonstrate that TriVax selectively enhanced the expansion of ACT cell populations bearing gp100-specific TCRs. T cells engineered to express CA-STAT5 showed not only increased expansion and polyfunctionality but also reduced PD-1 expression, leading to decreased cellular exhaustion. In a B16F10 melanoma mouse model, our approach yielded a potent antitumor effect, with CA-STAT5 further amplifying this response. We found that CA-STAT5 improved antitumor activities, in part, by attenuating the PD-1/PD-L1 inhibitory pathway. These findings indicate that TCR-transduced CD8 T cells can undergo antigen-dependent expansion when exposed to TriVax. Additionally, the expression of CA-STAT5 enhances T-cell proliferation and persistence, partly by promoting resistance to PD-1/PD-L1–mediated inhibition in antitumor T cells.

DOI： 10.1158/1535-7163.mct-24-0505

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Other Link： https://aacrjournals.org/mct/article-pdf/doi/10.1158/1535-7163.MCT-24-0505/3525091/mct-24-0505.pdf

Language：Japanese   Publisher：(一社)日本耳科学会  

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Authorship：Lead author,　Corresponding author   Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Oto-Rhino-Laryngological Society of Japan, Inc.  

DOI： 10.3950/jibiinkotokeibu.127.9_971

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Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1002/hed.27787

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Authorship：Lead author,　Last author,　Corresponding author   Language：Japanese   Publishing type：Research paper (scientific journal)  

DOI： 10.24805/jiaio.4.3_123

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Authorship：Corresponding author   Language：English   Publisher：(一社)日本癌学会  

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Authorship：Corresponding author   Language：English   Publisher：(一社)日本癌学会  

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Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：MDPI AG  

Intratumoral hypoxia is associated with tumor progression, aggressiveness, and therapeutic resistance in several cancers. Hypoxia causes cancer cells to experience replication stress, thereby activating DNA damage and repair pathways. MutT homologue-1 (MTH1, also known as NUDT1), a member of the Nudix family, maintains the genomic integrity and viability of tumor cells in the hypoxic tumor microenvironment. Although hypoxia is associated with poor prognosis and can cause therapeutic resistance by regulating the microenvironment, it has not been considered a treatable target in cancer. This study aimed to investigate whether hypoxia-induced MTH1 is a useful target for immunotherapy and whether hypoxic conditions influence the antitumor activity of immune cells. Our results showed that MTH1 expression was elevated under hypoxic conditions in head and neck cancer cell lines. Furthermore, we identified a novel MTH1-targeting epitope peptide that can activate peptide-specific CD4+ helper T cells with cytotoxic activity. The proliferation and cytotoxic activity of T cells were maintained under hypoxic conditions, and PD-1 blockade further augmented the cytotoxicity. These results indicate that MTH1-targeted immunotherapy combined with checkpoint blockade can be an effective strategy for the treatment of hypoxic tumors.

DOI： 10.3390/cancers16173013

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Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

DOI： 10.7759/cureus.66665

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Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1002/hed.27703

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Language：Japanese   Publisher：日本口腔・咽頭科学会  

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Language：Japanese   Publisher：日本口腔・咽頭科学会  

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Language：Japanese   Publisher：Japanese Society of Cancer Nursing  

DOI： 10.18906/jjscn.38_95_nonaka

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Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1111/coa.14195

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1007/s10157-024-02527-1

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DOI： 10.1111/cas.16079

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Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.anl.2023.08.006

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DOI： 10.3390/cancers16061205

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Lipomas are among the most common soft tissue tumors. Surgical removal of lipoma is considered if the patient has symptoms or cosmetic challenges. Lipomas that develop from any fat tissue in the body and involve the eustachian tube are extremely rare. Herein, we report the case of a patient with a lipoma arising in the eustachian tube. We also summarized the literature on tumors originating from the eustachian tubes. A 62-year-old female presented to our department with a five-year history of left nasal congestion. Nasal endoscopy revealed a tumor in the left eustachian tube. The tumor was considered a lipoma on computed tomography (CT) and magnetic resonance imaging (MRI) and was removed using a transnasal endoscopic approach. Nasal endoscopy and radiologic imaging can be used to detect tumors in the nasopharynx, including the eustachian tubes. Magnetic resonance imaging is particularly useful for the diagnosis of lipomas. A lipoma in the eustachian tube can cause nasal congestion and aural fullness, and the transnasal endoscopic approach is useful for tumor removal.

DOI： 10.7759/cureus.56597

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Authorship：Corresponding author   Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー感染症学会  

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Authorship：Corresponding author   Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー感染症学会  

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.anl.2023.08.002

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Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1159/000538365

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Language：Japanese   Publisher：JAPAN SOCIETY FOR HEAD AND NECK SURGERY  

Marine-Lenhart syndrome consists of coexisting Basedow’s and Plummer’s diseases. Here, we report a case of Marine-Lenhart syndrome, in which hyperthyroidism was detected during the follow-up of a thyroid tumor, and the diagnosis was made based on scintigraphy findings.
<br>A 69-year-old woman had been diagnosed with a left thyroid tumor more than 20 years ago. Because cytological examination suggested a benign tumor, surgical removal was not performed. She was diagnosed with hyperthyroidism by a local family doctor, and was referred to our department for further examination. TRAb was positive, and CT and echography showed a substantial mass with a maximum diameter of 32 mm in the left lobe of the thyroid gland. I¹²³ scintigraphy showed an accumulation in the left lobe tumor, and weak but diffuse accumulation in other lesions of the thyroid glands. Based on these findings, she was diagnosed with Marine-Lenhart syndrome. The patient was treated with total thyroidectomy, and no malignant findings were observed.

DOI： 10.5106/jjshns.34.99

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：The Society of Practical Otolaryngology  

DOI： 10.5631/jibirin.117.233

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Other Link： https://ndlsearch.ndl.go.jp/books/R000000004-I033365984

Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：The Society of Practical Otolaryngology  

DOI： 10.5631/jibirin.117.647

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Other Link： https://ndlsearch.ndl.go.jp/books/R000000004-I033616512

Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1159/000534516

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Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.3390/vaccines12010045

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.12659/AJCR.942070

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Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1002/emp2.13082

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Authorship：Corresponding author   Language：English  

DOI： 10.1007/s13760-023-02181-6

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Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.anl.2023.01.011

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1002/emp2.13087

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Immune checkpoint inhibitors (ICIs) are a novel treatment option for treating head and neck squamous cell carcinoma (HNSCC). Among the immune-related adverse effects, cerebral infarction (CI) is a rare but fatal complication, and it has been reported in various cancers, except HNSCC. Herein, we describe three cases of patients diagnosed with HNSCC who experienced CI following ICI treatment. In addition, we conducted a comprehensive literature review on ICI-related thrombosis. Three patients with recurrent HNSCC were treated with nivolumab. Two patients had a history of CI, or heart disease, and were concurrently prescribed antithrombotic medications during nivolumab treatment. The number of nivolumab administrations varied from 1-25 before the onset of CI. All patients experienced worsening of neurological symptoms due to CI, irrespective of antithrombotic treatment, and they ultimately succumbed to the disease within 16-222 days following their initial ICI administration. ICIs may cause thromboembolisms, leading to CI. Based on our review of the literature, a history of thromboembolism or heart disease could be a risk factor for ICI-related thrombosis.

DOI： 10.7759/cureus.47406

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Language：English   Publisher：(一社)日本癌学会  

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Language：English   Publisher：(一社)日本癌学会  

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Authorship：Lead author,　Corresponding author   Language：English  

Upper airway infections caused by anaerobic bacteria, including pharyngitis and tonsillitis, are a common cause of septic thrombosis (Lemierre's syndrome). Although otitis media rarely progresses to systemic infection, an abscess surrounding the middle ear can affect the central nervous system. Trueperella bernardiae was originally considered a non-pathogenic aerobic bacterium but has subsequently been reported to cause bacteremia and brain abscesses. Here, we report a case of otitis media caused by T. bernardiae complicated by meningitis, subdural empyema, and septic pulmonary emboli in an immunocompetent patient.

DOI： 10.7759/cureus.42977

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Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1007/s00262-023-03460-0

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.anl.2022.04.011

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Language：Japanese   Publisher：日本口腔・咽頭科学会  

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Language：Japanese   Publisher：日本口腔・咽頭科学会  

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Language：Japanese   Publisher：日本口腔・咽頭科学会  

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1007/s00262-023-03394-7

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Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

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Language：Japanese   Publisher：(一社)日本頭頸部癌学会  

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Language：Japanese   Publisher：(一社)日本頭頸部癌学会  

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Language：Japanese   Publisher：(一社)日本耳鼻咽喉科頭頸部外科学会  

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Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー感染症学会  

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Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー感染症学会  

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Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー感染症学会  

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Authorship：Lead author   Language：Japanese   Publisher：一般社団法人 日本耳鼻咽喉科頭頸部外科学会  

免疫療法は癌治療において手術, 抗癌剤, 放射線療法に次ぐ第4の柱として確立された. 現状で用いられている免疫療法は, 腫瘍や腫瘍微小環境において抗腫瘍免疫を抑制する負の免疫チェックポイント分子への阻害抗体であり, PD-1 / PD-L1 や CTLA-4 がその代表的な分子として挙げられる. これらの分子に対する中和抗体は抗原性が高い悪性腫瘍として知られる悪性黒色腫で臨床応用が開始され, 一定の臨床効果を示した. 頭頸部癌も比較的抗原性が高い腫瘍として知られており, 2017年に Nivolumab, 2019年には Pembrolizumab の臨床応用が開始された. 臨床応用から数年が経過し, 免疫療法はリアルワールドで2割前後の奏効率を示している. 免疫チェックポイント阻害薬の使用に対するハードルは下がり, 全国で多くの耳鼻咽喉科・頭頸部外科医が免疫療法に携わっている. そのため, 臨床医にとっても頭頸部癌における腫瘍免疫の詳細な理解が求められるようになってきた. 本稿では, 頭頸部癌を中心とした増殖・転移に関するメカニズムおよび腫瘍免疫を応用した治療法の現状と未来について概説する.

DOI： 10.3950/jibiinkotokeibu.126.2_81

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Other Link： https://ndlsearch.ndl.go.jp/books/R000000004-I032702551

Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1111/cas.15619

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：The Society of Practical Otolaryngology  

DOI： 10.5631/jibirin.116.45

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Other Link： https://ndlsearch.ndl.go.jp/books/R000000004-I032613586

Language：Japanese   Publisher：Japan Society of Stomato-pharyngology  

Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis （PFAPA） syndrome is an autoinflammatory disease and is generally seen in children under 5 years of age. Because the etiology and pathogenesis of PFAPA syndrome are unknown, the syndrome is often misdiagnosed as recurrent tonsillitis. Medication is normally chosen for the first treatment, but tonsillectomy is considered when the medication is ineffective. Herein, we report five cases of PFAPA syndrome who underwent tonsillectomy in our department. The age of onset ranged from 0 to 5 years （median 3 years）, and the age at tonsillectomy ranged from 2 to 7 years （median 5 years）. Symptoms included periodic fever in 5 cases, aphthous stomatitis in 1 case, cervical lymphadenitis in 2 cases, and pharyngitis in 5 cases. After tonsillectomy, the periodic fever disappeared in four cases, and the fever onset became less frequent in the remaining case. Therefore, tonsillectomy was effective in the treatment of PFAPA syndrome. When patients are introduced by a pediatrician who suggests that tonsillectomy is indicated because of failure of the initial treatment, we should recommend the operation for the patients.

DOI： 10.14821/stomatopharyngology.36.102

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Authorship：Lead author   Language：Japanese   Publisher：日本鼻科学会  

DOI： 10.7248/jjrhi.62.269

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Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.bjorl.2023.03.005

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：The Society of Practical Otolaryngology  

DOI： 10.5631/jibirin.116.25

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Other Link： https://ndlsearch.ndl.go.jp/books/R000000004-I032613572

Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：The Society of Practical Otolaryngology  

DOI： 10.5631/jibirin.116.161

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Other Link： https://ndlsearch.ndl.go.jp/books/R000000004-I032678749

Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.bjorl.2022.12.004

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Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1002/lio2.863

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Language：English   Publisher：(一社)日本癌学会  

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1111/cas.15429

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Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.3390/cancers14122924

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Language：English   Publisher：耳鼻咽喉科臨床学会  

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Language：Japanese   Publisher：(一社)日本耳鼻咽喉科頭頸部外科学会  

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DOI： 10.1016/j.tranon.2022.101358

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Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー感染症学会  

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Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー感染症学会  

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Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー感染症学会  

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Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.3390/vaccines10010070

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Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1111/coa.13876

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Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.22037/aaem.v10i1.1430

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Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1080/2162402X.2021.2021619

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Language：Japanese   Publisher：東京 : 眼科臨床紀要会  

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Other Link： https://ndlsearch.ndl.go.jp/books/R000000004-I031935216

Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：The Society of Practical Otolaryngology  

DOI： 10.5631/jibirin.115.503

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Other Link： https://ndlsearch.ndl.go.jp/books/R000000004-I032223454

Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：The Society of Practical Otolaryngology  

DOI： 10.5631/jibirin.115.485

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Other Link： https://ndlsearch.ndl.go.jp/books/R000000004-I032223433

Authorship：Lead author   Language：Japanese   Publisher：Japanese Society of Otorhinolaryngology-Head and Neck Surgery  

DOI： 10.3950/jibiinkotokeibu.124.12_1565

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Other Link： https://ndlsearch.ndl.go.jp/books/R000000004-I031892771

Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1007/s00262-021-02940-5

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1084/jem.20200792

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Language：Japanese   Publisher：(一社)日本鼻科学会  

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Language：English   Publisher：(一社)日本癌学会  

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Language：English   Publisher：(一社)日本癌学会  

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Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1002/jha2.233

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1007/s00262-021-02864-0

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1111/cas.14973

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.3390/microorganisms9071381

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Language：Japanese   Publisher：THE JAPAN LARYNGOLOGICAL ASSOCIATION  

A 41-year-old woman, presented with sore throat and dyspnea of 1 week’s duration. Fiberoptic laryngoscopy showed a swollen edematous epiglottis. Because the patient developed stridor and shortness of breath, tracheostomy was performed to secure the airway. Contrast-enhanced computed tomography (CT) showed high-density areas in the epiglottis, base of the tongue, and aryepiglottic folds. The patient was positive for proteinase 3 (PR3)-antineutrophil cytoplasmic antibody (ANCA, 4.9 U/ml) and negative for myeloperoxidase (MPO)-ANCA. A histo-pathological examination of an epiglottis biopsy specimen showed geographic necrotizing granuloma with a few scattered multinucleated giant cells. Transmural inflammation, luminal occlusion, and vessel disruption were observed on elastic staining. Based on these findings, the patient was diagnosed with granulomatosis with polyangiitis (GPA). Two months after the patient started therapy with high-dose steroids and cyclophosphamide, the epiglottic swelling improved. The level of PR3-ANCA returned to the normal range two months after starting treatment. Subglottic stenosis is reportedly a common clinical feature of GPA. Although the involvement of supraglottic structures, including the epiglottis, is rare in GPA, clinicians should include GPA in the differential diagnosis of a life-threatening airway obstruction.

DOI： 10.5426/larynx.33.31

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Other Link： https://search.jamas.or.jp/link/ui/2022112462

Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー感染症学会  

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Language：Japanese   Publisher：(一社)日本頭頸部癌学会  

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Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー感染症学会  

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Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー感染症学会  

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Language：Japanese   Publisher：(一社)日本耳鼻咽喉科頭頸部外科学会  

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Language：Japanese   Publisher：(一社)日本耳鼻咽喉科頭頸部外科学会  

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Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1002/hed.26502

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：The Society of Practical Otolaryngology  

DOI： 10.5631/jibirin.114.801

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Other Link： https://ndlsearch.ndl.go.jp/books/R000000004-I031757885

Language：Japanese   Publisher：Japan Rhinologic Society  

The Japanese Rhinologic Society has held a “Hands-on Seminar on Basic Research for Clinicians” led by the Society since 2014. The aims of the seminar are to raise the motivation and research skills for basic research among clinical otorhinolaryngologists, and to encourage interdisciplinary collaboration through research with universities. The attendees at the seminar are clinicians who are performing basic research in Japan. The seventh seminar was held at the 59th Annual Meeting of the Japanese Rhinologic Society (Tokyo), and focused on isolation of mononuclear cells from peripheral blood, nasal polyps, and tonsils. In contrast to past seminars, the seminar was held online and experimental procedures were shown by video because of the worldwide SARS-CoV-2 pandemic. A questionnaire completed by participants indicated a high level of satisfaction and a belief that the research seminar is needed. The seminar provides a great opportunity for rhinologists to obtain ideas for expansion of avenues for basic understanding of rhinologic disorders, and we believe that it should be continued for as long as possible.

DOI： 10.7248/jjrhi.60.566

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Language：Japanese   Publisher：JAPAN SOCIETY FOR HEAD AND NECK SURGERY  

We experienced two cases of tracheostomy for a new coronavirus positive patient （COVID-19）. Case 1 was a man in his 80s. Long-term tracheal intubation management was required, so a tracheostomy was performed with full PPE using an N95 mask. Case 2 was a man in his 60s. Given that it was difficult to secure a visual field in the first tracheostomy, a surgical tracheotomy was performed under a powered air-purifying respirator （PAPR）. By using the PAPR, we were able to solve the problem of securing the visual field when performing surgical tracheostomy with full PPE, and it was considered to be useful for surgical tracheostomy under safe infection control.

DOI： 10.5106/jjshns.21-006

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Language：Japanese   Publisher：Japan Society for Pediatric Otorhinolaryngology  

Burkitt lymphoma is a high-grade B-cell lymphoma. In children, the symptoms of this disease vary depending on the primary site and include a few systemic symptoms, including fever and weight loss. Malignant lymphoma of the nasal cavity and paranasal sinuses is very rare. Herein, we report two cases of Burkitt lymphoma in the paranasal sinuses in children with rapid onset of visual impairment.

Both cases developed visual impairment and were admitted to the pediatric department and then referred to our department. Computed tomography and magnetic resonance imaging revealed mass lesions in the paranasal sinuses. Biopsies led to diagnosis of Burkitt lymphoma. Chemotherapy was administered and complete remission has been maintained since the end of treatment. However, blindness developed as a complication in case 1. These cases emphasize the need to be aware of the rapid progression of symptoms of Burkitt lymphoma.

DOI： 10.11374/shonijibi.42.342

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Other Link： https://ndlsearch.ndl.go.jp/books/R000000004-I032540742

Language：Japanese   Publisher：Japan Rhinologic Society  

Thyroid-like low grade nasopharyngeal papillary adenocarcinoma (TL-LGNPPA) is a rare malignant tumor that originates in the nasopharynx. Pathologically, the tumor shows papillary thyroid cancer-like findings of a thyroid transcription factor-1 (TTF-1)-positive and thyroglobulin (TG)-negative status. We report a case of nasopharyngeal papillary adenocarcinoma at the posterior end of the nasal septum.

A 50-year-old woman presented with sore throat in our department. Nasal endoscopy revealed a pedunculated tumor at the posterior end of the nasal septum. CT and MRI showed a pedunculated tumor without cervical lymph node swelling. Biopsy revealed a TL-LGNPPA that was TTF-1-positive and TG-negative. The tumor was endoscopically resected under general anesthesia without any complications. The pathological margin was negative. No recurrence or metastasis has been observed in one year and 6 months after the operation.

DOI： 10.7248/jjrhi.60.495

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Other Link： https://search.jamas.or.jp/link/ui/2022105062

Authorship：Lead author   Language：Japanese   Publisher：Japan Society of Immunology, Allergology and Infection in Otorhinolaryngology  

Extranodal NK/T cell lymphoma, nasal type (nasal NK/T cell lymphoma) is a rare malignant disease, which mainly involves the head and neck. In the late 20^th century, monoclonal expression of Epstein–Barr virus (EBV) was detected in a clinical specimen. Subsequently, accumulating evidence has suggested that EBV and its related protein play an etiological role in the aggressive proliferation of this lymphoma. The viral load of EBV in serum has been used as a prognostic marker in clinical practice. EBV-derived micro-RNA is also a reliable marker for the progression of lymphoma. This lymphoma produces several cytokines and chemokines to proliferate under the EBV-LMP1-mediated pathway. In addition to its pathological role, EBV is an ideal target for immunotherapy. We have previously described that EBV-LMP1 contains an epitope that could activate antitumor CD4 helper T cells. Here, I briefly summarize the current knowledge regarding the etiological role of EBV in nasal NK/T cell lymphoma, the immune microenvironment surrounding this lymphoma, and the novel treatment strategy of targeting EBV with antitumor immune cells.

DOI： 10.24805/jiaio.1.3_147

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Authorship：Lead author   Language：Japanese   Publisher：Japan Society of Stomato-pharyngology  

DOI： 10.14821/stomatopharyngology.34.157

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Other Link： https://ndlsearch.ndl.go.jp/books/R000000004-I032533165

Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：The Society of Practical Otolaryngology  

DOI： 10.5631/jibirin.114.231

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Other Link： https://ndlsearch.ndl.go.jp/books/R000000004-I031317815

Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：The Society of Practical Otolaryngology  

DOI： 10.5631/jibirin.114.373

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Other Link： https://ndlsearch.ndl.go.jp/books/R000000004-I031498545

Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：The Society of Practical Otolaryngology  

DOI： 10.5631/jibirin.114.553

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Other Link： https://ndlsearch.ndl.go.jp/books/R000000004-I031604893

Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1080/2162402X.2020.1856545

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Language：Japanese   Publisher：THE JAPAN LARYNGOLOGICAL ASSOCIATION  

Varicella-zoster virus (VZV) reactivation is known to rarely cause inferior cranial nerve paralysis with symptoms such as pharyngeal pain, hoarseness, and dysphagia. We herein report 5 cases involving patients with laryngeal paralysis caused by VZV reactivation, in which the diagnosis was confirmed by a serological analysis. The symptoms of the five patients included pharyngeal pain (n=4), hoarseness (n=3), and dysphagia (n=3). The 5 patients were treated with acyclovir (750 mg/day) for 7 days and intravenous steroids; all patients were cured and achieved complete relief from their symptoms after various periods of time.

Among the 69 patients with laryngeal paralysis caused by VZV that were reported in the relevant Japanese literature (including our 5 patients), 53 of the 56 patients (95%) showed symptoms of sore throat, hoarseness, or dysphagia. Vagal (X), glossopharyngeal (Ⅸ), facial (Ⅶ) and hypoglossal (Ⅻ) nerve paralysis was reportedly observed in 69 (100%), 56 (81%), 30 (43%) and 6 (7%) of the 69 patients, respectively. Forty-nine (71%) of the 69 patients were treated with the combination of acyclovir and steroids, and 52 (75%) patients with laryngeal paralysis were cured.

In consideration of our 5 patients and the 64 patients reported in the relevant literature, in cases in which symptoms such as pharyngeal pain, hoarseness, and dysphagia, and findings of erythema and laryngeal paralysis are not found simultaneously, careful and frequent endoscopic observation could lead to an early diagnosis and appropriate treatment of laryngeal paralysis caused by VZV.

DOI： 10.5426/larynx.32.189

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Other Link： https://search.jamas.or.jp/link/ui/2021130319

Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1002/ccr3.3424

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Language：Japanese   Publisher：(一社)日本鼻科学会  

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Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.jpeds.2020.06.010

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Language：Japanese   Publisher：日本がん免疫学会  

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Language：Japanese   Publisher：日本がん免疫学会  

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Language：Japanese   Publisher：The Japan Broncho-esophagological Society  

Parathyroid cysts are benign tumors that present with neck swelling. Among such cysts, 10% of cases are functional and 90% are non-functional. Aspiration of cystic fluid or surgical resection is recommended. For surgical resection, video-assisted neck surgery (VANS) has advantages in terms of aesthetic aspect and recognition of nerves, vessels and parathyroid with an expanded view. Although numerous thyroid tumors are operated by VANS, few such cases have been reported. Here, we report two cases of patients with parathyroid cyst operated by VANS.

DOI： 10.2468/jbes.71.325

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Other Link： https://ndlsearch.ndl.go.jp/books/R000000004-I030602931

Language：Japanese   Publisher：(一社)日本頭頸部癌学会  

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Language：Japanese   Publisher：THE JAPAN LARYNGOLOGICAL ASSOCIATION  

We herein report the case of a patient with adult T-cell leukemia of the larynx.Adult T cell Leukemia was first described by Takatsuki in 1975. ATL is associated with human T cell lymphotropic virus typeⅠ(HTLV-1). Patients with this condition usually show lymphadenopathy and skin rash. The association of local laryngeal mass lesions is rare.

The patient, a 67-year-old woman, complained of throat pain that persisted for two weeks. She had a tumor of the epiglottis as well as cervical lymphadenopathy, and ulceration of a finger. To obtain a definite diagnosis, we obtained a biopsy specimen from the laryngeal tumor; however, the lesion was necrotic. Thus, we then obtained a biopsy specimen of the right cervical lymph node. The pathological findings suggested malignant lymphoma originating from the T cells. HTLV-1 was found in her serum, and a provirus was identified in ATL cells. The patient was treated with chemotherapy and the epiglottal mass gradually disappeared.

Otolaryngologists should consider ATL in the differential diagnosis of laryngeal carcinoma.

DOI： 10.5426/larynx.32.73

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Other Link： https://search.jamas.or.jp/link/ui/2021000989

Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1007/s00262-020-02524-9

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Authorship：Lead author   Language：Japanese   Publisher：Japan Society for Infection and Aerosol in Otorhinolaryngology  

The clinical course of common cold is typically self-limiting, and specific treatments are not required to cure common cold. Meanwhile, the clinical symptoms of common cold, such as sore throat and headache, are frequently found in life-threatening diseases. Therefore, it is necessary to understand red flag signs and differentiate common cold from other diseases. For risk assessment and management, the early detection of vulnerable patients prevents the further development of fatal diseases that resemble common cold. In this review, we summarize the risk factors and details of “common cold”-like serious diseases.

DOI： 10.24805/jjsiao.8.2_129

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.bbrc.2019.11.107

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Language：Japanese   Publisher：日本耳鼻咽喉科感染症・エアロゾル学会  

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Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1159/000509485

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：The Society of Practical Otolaryngology  

DOI： 10.5631/JIBIRIN.113.787

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Other Link： https://ndlsearch.ndl.go.jp/books/R000000004-I030799723

Language：Japanese   Publisher：Japan Society of Stomato-pharyngology  

We report a case of myoepithelioma in the hard palate. The patient was a 69-year-old woman with a mass in the hard palate. The hard elastic mass was covered with normal mucosa and located on the right side of the hard palate. We diagnosed myoepithelioma by biopsy and surgically removed the tumor. An epithelioid organization was the main histopathology finding, and multiple histology was mixed. Actin, αSMA, and S-100 protein, which is a marker of the myoepithelium system, and GFAP were positive by immunostaining. The MIB-1 index, which is an index of malignancy, was 5％, suggesting the mass was benign. A diagnosis of myoepithelioma（mixed type）was made. Postoperative observation revealed no recurrence as of 10 months after the operation, but there are reports of recurrence and malignant transformation, so careful follow-up is necessary.

DOI： 10.14821/stomatopharyngology.33.45

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Other Link： https://ndlsearch.ndl.go.jp/books/R000000004-I032538511

Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

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Language：Japanese   Publisher：(一社)日本耳科学会  

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Language：English   Publisher：(一社)日本癌学会  

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Language：English   Publisher：(一社)日本癌学会  

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Language：English   Publisher：(一社)日本癌学会  

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Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.cellimm.2019.103925

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Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1186/s12967-019-1957-5

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Authorship：Lead author   Language：Japanese   Publisher：耳鼻咽喉科展望会  

DOI： 10.11453/orltokyo.62.supplement1_s34

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Authorship：Lead author   Language：Japanese   Publisher：THE JAPAN LARYNGOLOGICAL ASSOCIATION  

We herein report a patient with late-onset laryngeal stenosis after burn and inhalation injury. The patient, an 18-year-old male, suffered a burn and smoke inhalation injury. Because of laryngeal edema, the patient was intubated for two days followed by tracheotomy. Fourteen days later, endoscopic laryngoscopy revealed normal laryngeal finding. However, 14 months after the injury, he started to complain of hoarseness and respiratory distress. Given findings of a severe reduction in oxygen saturation, the patient underwent tracheotomy. A laryngeal examination revealed posterior glottic adhesion that was released by laryngeal microsurgery with steroid injection. Over one year of follow-up, no recurrence of his laryngeal stenosis was observed. Although late-onset laryngeal stenosis after burn and inhalation injury is rare, clinicians should consider the risk of this potentially fatal condition in susceptible patients.

DOI： 10.5426/larynx.31.34

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Other Link： https://search.jamas.or.jp/link/ui/2019300654

Language：Japanese   Publisher：耳鼻咽喉科臨床学会  

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1038/s41374-018-0182-9

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Language：Japanese   Publisher：(一社)日本アレルギー学会  

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Language：Japanese   Publisher：(一社)日本アレルギー学会  

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Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1007/s00262-018-02294-5

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Authorship：Lead author,　Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.3389/fped.2019.00141

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Language：English   Publishing type：Research paper (scientific journal)  

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Authorship：Lead author   Language：Japanese   Publishing type：Research paper (scientific journal)  

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Authorship：Lead author   Language：Japanese   Publishing type：Research paper (scientific journal)  

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Authorship：Lead author   Language：Japanese   Publishing type：Research paper (scientific journal)  

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Authorship：Lead author   Language：Japanese   Publishing type：Research paper (scientific journal)  

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Authorship：Lead author   Language：Japanese   Publisher：Japan Rhinologic Society  

The Japanese Rhinologic Society has held “Hands-on Seminar on Basic Research for Clinicians” led by the Society since 2014. These seminars are planned with the aim of raising the motivation and research skills of clinical otorhinolaryngologists toward basic research, and in turn to encourage inter-disciplinary collaboration through research with universities. The fifth seminar was held at the 57^th Annual Meeting of the Japanese Rhinologic Society (Asahikawa) including four different topics, isolation of single cells from nasal samples, ELISA, Western blot, and CRISPER-Cas9. Based on the questionnaire, the participants had a high need and satisfaction of these research seminars. Because this seminar is a great opportunity for rhinologists to obtain an idea to expand the avenue of basic understanding of rhinologic disorders, this seminar should be continued as far as there is a demand.

DOI： 10.7248/jjrhi.58.152

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Other Link： https://search.jamas.or.jp/link/ui/2023114525

Language：Japanese   Publisher：Japan Rhinologic Society  

Primary malignant lymphoma rarely occurs in extranodal organs such as the paranasal sinus. However, the prognosis of the small number of patients with primary malignant lymphoma of the paranasal sinus is poor. Herein, we report five patients with this disease who were treated in our department. Three patients were male and two were female. The median age of the patients was 75 years, with an age range of 55 to 84 years. The maxillary sinus was involved in all cases. Histological examination revealed that three cases were diffuse large B-cell lymphoma, one was follicular lymphoma, and one was high-grade B-cell lymphoma, not otherwise specified. Based on the Ann Arbor system, two patients were classified as Stage IEA, two as Stage IIEA, and one as Stage IVEA. Three patients were treated with chemoradiotherapy, one with chemotherapy alone, and one with radiotherapy alone. All patients achieved complete response (CR) with initial treatment, but two relapsed. The overall CR rate was 80% with salvage treatment (chemotherapy or removal of skin metastasis). The high curability rate suggests that chemoradiation is effective for treatment of B-cell origin malignant lymphoma of the paranasal sinus.

DOI： 10.7248/jjrhi.58.698

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Authorship：Lead author   Language：Japanese   Publisher：日本鼻科学会  

DOI： 10.7248/jjrhi.58.107

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Other Link： https://search.jamas.or.jp/link/ui/2019308332

Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1007/s00262-018-2164-6

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Language：Japanese   Publisher：耳鼻咽喉科臨床学会  

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Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1158/2326-6066.CIR-17-0549

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Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1080/2162402X.2018.1466771

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：JAPAN SOCIETY OF IMMUNOLOGY AND ALLERGOLOGY IN OTOLARYNGOLOGY  

Nasal NK/T-cell lymphoma (NNKTL) is characterized by progressive necrotic lesions in the nasal cavity and/or palate. NNKTL cells are derived from two lineages, NK- and γδT-cell. Our previous studies showed the presence of Epstein-Barr virus (EBV) DNA, EBV oncogenic proteins, and the clonotypic EBV genome in this lymphoma, indicating that NNKTL is an EBV-related malignancy. It has been established histologically that many inflammatory cells such as lymphocytes, monocytes, and macrophages infiltrate NNKTL tissue. This finding gives rise to the speculation that tumor-reactive T lymphocytes might also exist in NNKTL tissue to attack the lymphoma cells. EBV-encoded latent membrane protein 1 (LMP1) has oncogenic potential and is expressed in NNKTL. Thus, LMP1 is regarded as a potential tumor-associated antigen for immunotherapy. In this review, we present the identification of a peptide epitope derived from the EBV-LMP1 antigen that is capable of stimulating CD4 helper T-lymphocyte responses in the context of several human leukocyte antigen class II alleles. Furthermore, we discuss the therapeutic strategies of the peptide immunotherapy combined with immune adjuvants and anti-programmed death-1/programmed death-ligand 1 antibodies for NNKTL.

DOI： 10.5648/jjiao.36.15

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1080/2162402X.2018.1483302

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1158/0008-5472.CAN-16-1925

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Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.coi.2017.07.003

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1007/s00262-017-1987-x

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1007/s00262-017-1975-1

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Language：English   Publisher：日本がん免疫学会  

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Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.coi.2016.11.001

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1007/s00262-016-1834-5

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Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1158/2326-6066.CIR-16-0194

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Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1189/jlb.3CE0216-091R

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Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1080/2162402X.2016.1169356

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Other Link： http://amcor.asahikawa-med.ac.jp/modules/xoonips/detail.php?id=27471649

Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.18632/oncotarget.8197

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Language：English   Publishing type：Research paper (scientific journal)  

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Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1002/hed.23906

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Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.2217/imt.15.103

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Other Link： http://amcor.asahikawa-med.ac.jp/modules/xoonips/detail.php?id=26642249

Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1038/srep16280

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Other Link： https://www.nature.com/articles/srep16280

Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1007/s00262-015-1675-7

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Other Link： http://link.springer.com/content/pdf/10.1007/s00262-015-1675-7.pdf

Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

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Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.4161/2162402X.2014.976077

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Language：Japanese   Publishing type：Research paper (scientific journal)  

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Other Link： http://amcor.asahikawa-med.ac.jp/modules/xoonips/detail.php?id=2015169489

Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1186/s12967-014-0265-3

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CiNii Research

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Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1007/s00262-014-1533-z

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Language：Japanese   Publishing type：Research paper (scientific journal)  

CiNii Research

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Other Link： http://amcor.asahikawa-med.ac.jp/modules/xoonips/detail.php?id=2014228829

Authorship：Lead author   Language：Japanese   Publisher：JAPAN SOCIETY OF IMMUNOLOGY AND ALLERGOLOGY IN OTOLARYNGOLOGY  

Overexpression of tumor antigens is commonly observed in head and neck squamous cell carcinoma (HNSCC) that is a fatal and common disease in Japan. Although some tumor antigen molecules on HNSCC have been elucidated, effective immunotherapy using these antigens for HNSCC has not been developed. We previously showed that tumor antigen-specific helper T cells had the ability to kill HNSCC cell lines. Moreover, immune modulators such as EGFR inhibitors could upregulate these antitumor T cell responses. In this review, we present the current understanding of helper T-cell mediated anti-tumor immunity and molecule-targeted therapies that can augment anti-tumor T-cell responses. A detailed understanding of anti-tumor immunity and the mechanisms of immune enhancers may provide a platform for establishing combinatorial immunotherapy with adjuvants in treatment for HNSCC.

DOI： 10.5648/jjiao.32.185

CiNii Research

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Other Link： http://amcor.asahikawa-med.ac.jp/modules/xoonips/detail.php?id=20141225

Authorship：Lead author   Publishing type：Research paper (scientific journal)  

DOI： 10.1038/bjc.2013.577

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Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：The Society of Practical Otolaryngology  

DOI： 10.5631/jibirin.106.423

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CiNii Books

CiNii Research

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Other Link： http://id.ndl.go.jp/bib/024650788

Language：Japanese   Publisher：耳鼻咽喉科展望会  

DOI： 10.11453/orltokyo.56.128

CiNii Research

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Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1007/s00262-012-1284-7

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Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：The Society of Practical Otolaryngology  

DOI： 10.5631/jibirin.105.277

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CiNii Books

CiNii Research

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Other Link： http://id.ndl.go.jp/bib/023577759

Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1186/1479-5876-9-191

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1159/000324789

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Language：English   Book type：Scholarly book

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Total pages：xii, 234 p.   Language：English  

CiNii Books

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Authorship：Lead author,　Corresponding author   Language：English   Publisher：Elsevier BV  

DOI： 10.1016/j.anl.2025.02.005

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Authorship：Lead author,　Corresponding author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

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J-GLOBAL

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Authorship：Lead author,　Last author,　Corresponding author   Language：Japanese   Publisher：(株)全日本病院出版会  

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Authorship：Lead author,　Last author,　Corresponding author   Language：Japanese   Publisher：(株)全日本病院出版会  

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J-GLOBAL

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J-GLOBAL

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J-GLOBAL

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J-GLOBAL

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Authorship：Lead author,　Last author,　Corresponding author   Language：Japanese   Publisher：(株)全日本病院出版会  

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Authorship：Lead author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)   Publisher：全日本病院出版会  

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Authorship：Lead author,　Corresponding author   Language：Japanese   Publisher：東京 : 先端医学社  

CiNii Books

CiNii Research

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Other Link： https://ndlsearch.ndl.go.jp/books/R000000004-I032538138

Authorship：Lead author,　Last author,　Corresponding author   Language：Japanese   Publisher：(有)科学評論社  

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J-GLOBAL

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J-GLOBAL

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Authorship：Lead author,　Last author,　Corresponding author   Language：Japanese   Publisher：東京 : 日本臨床社  

CiNii Books

CiNii Research

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Other Link： https://ndlsearch.ndl.go.jp/books/R000000004-I031577955

Authorship：Last author   Language：Japanese   Publisher：東京 : 日本臨床社  

CiNii Books

CiNii Research

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Other Link： https://ndlsearch.ndl.go.jp/books/R000000004-I031577939

Authorship：Lead author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)   Publisher：日本臨床社  

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J-GLOBAL

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J-GLOBAL

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J-GLOBAL

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J-GLOBAL

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J-GLOBAL

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J-GLOBAL

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J-GLOBAL

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Language：Japanese   Publisher：大阪 : 医薬ジャーナル社  

DOI： 10.20837/3201806748

CiNii Books

CiNii Research

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Other Link： https://ndlsearch.ndl.go.jp/books/R000000004-I029070594

Authorship：Last author   Language：Japanese   Publisher：(株)全日本病院出版会  

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Authorship：Corresponding author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)   Publisher：全日本病院出版会  

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Authorship：Lead author,　Last author,　Corresponding author   Language：Japanese   Publisher：(有)科学評論社  

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Authorship：Lead author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

DOI： 10.11477/mf.1411201432

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CiNii Research

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2017&ichushi_jid=J02122&link_issn=&doc_id=20171101160010&doc_link_id=10.11477%2Fmf.1411201432&url=https%3A%2F%2Fdoi.org%2F10.11477%2Fmf.1411201432&type=%E5%8C%BB%E6%9B%B8.jp_%E3%82%AA%E3%83%BC%E3%83%AB%E3%82%A2%E3%82%AF%E3%82%BB%E3%82%B9&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

Authorship：Lead author,　Last author,　Corresponding author   Language：Japanese   Publisher：(株)東京医学社  

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Authorship：Lead author,　Corresponding author   Language：Japanese   Publisher：(株)Gakken  

扁桃病巣疾患の概念、掌蹠膿疱症や乾癬に対する扁摘の有効性、扁摘の安全性、扁桃を病巣とした掌蹠膿疱症の発症機序について概説した。これまでの報告によって、扁摘は掌蹠膿疱症に対してきわめて有効であり、扁摘以外の治療法よりも優れていることが示されている。また、掌蹠膿疱症の発症機序として、扁桃の常在菌に対する過剰免疫応答による扁桃B細胞の熱ショックタンパク質などに対する抗体産生と扁桃T細胞の掌蹠皮膚へのホーミングが関与している可能性が示唆されている。扁摘は安全な手術であり、掌蹠膿疱症に対する治療として医療経済的にもきわめて有効といえる。

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Authorship：Lead author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)   Publisher：東京医学社  

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Authorship：Lead author,　Corresponding author   Language：Japanese   Publisher：(株)東京医学社  

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J-GLOBAL

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Authorship：Lead author,　Last author,　Corresponding author   Language：Japanese   Publisher：(株)東京医学社  

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Authorship：Last author   Language：Japanese   Publisher：(株)東京医学社  

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Event date： 2021.5

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

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Event date： 2019.7

Language：Japanese   Presentation type：Oral presentation (invited, special)  

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Event date： 2019.6

Language：Japanese   Presentation type：Oral presentation (general)  

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