Updated on 2025/11/01

写真a

 
KANEKO Toshiyuki
 
Organization
School of Medicine Medical Course Basic Medicine Physiology[Autonomous Function]
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Degree

  • 博士（理学） ( 2007.3   新潟大学 )

Research Interests

  • イオンチャネル

  • メカノバイオロジー

  • physiology

Research Areas

  • Life Science / Plants: molecular biology and physiology

  • Life Science / Physiology

  • Life Science / Biomedical engineering

Education

  • Niigata University   Graduate School of Science and Technology   Specialized Course of Life and Food Sciences

    - 2007.3

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Research History

  • Asahikawa Medical College   School of Medicine   Assistant Professor

    2014.4

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  • 岡山大学大学院医歯薬学総合研究科   特任教員（助教）

    2011.4 - 2014.3

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  • 岡山大学資源植物科学研究所   特任教員（助教）

    2007.4 - 2011.3

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Professional Memberships

  • THE PHYSIOLOGICAL SOCIETY OF JAPAN

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  • THE BIOPHYSICAL SOCIETY OF JAPAN

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  • JAPANESE SOCIETY FOR MEDICAL AND BIOLOGICAL ENGINEERING

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  • JAPAN SOCIETY OF SMOOTH MUSCLE RESEARCH

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Papers

  • Myocardial TRPC6-mediated Zn2+ influx induces beneficial positive inotropy through β-adrenoceptors. Reviewed International journal

    Sayaka Oda, Kazuhiro Nishiyama, Yuka Furumoto, Yohei Yamaguchi, Akiyuki Nishimura, Xiaokang Tang, Yuri Kato, Takuro Numaga-Tomita, Toshiyuki Kaneko, Supachoke Mangmool, Takuya Kuroda, Reishin Okubo, Makoto Sanbo, Masumi Hirabayashi, Yoji Sato, Yasuaki Nakagawa, Koichiro Kuwahara, Ryu Nagata, Gentaro Iribe, Yasuo Mori, Motohiro Nishida

    Nature communications   13 ( 1 )   6374 - 6374   2022.10

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    Baroreflex control of cardiac contraction (positive inotropy) through sympathetic nerve activation is important for cardiocirculatory homeostasis. Transient receptor potential canonical subfamily (TRPC) channels are responsible for α1-adrenoceptor (α1AR)-stimulated cation entry and their upregulation is associated with pathological cardiac remodeling. Whether TRPC channels participate in physiological pump functions remains unclear. We demonstrate that TRPC6-specific Zn2+ influx potentiates β-adrenoceptor (βAR)-stimulated positive inotropy in rodent cardiomyocytes. Deletion of trpc6 impairs sympathetic nerve-activated positive inotropy but not chronotropy in mice. TRPC6-mediated Zn2+ influx boosts α1AR-stimulated βAR/Gs-dependent signaling in rat cardiomyocytes by inhibiting β-arrestin-mediated βAR internalization. Replacing two TRPC6-specific amino acids in the pore region with TRPC3 residues diminishes the α1AR-stimulated Zn2+ influx and positive inotropic response. Pharmacological enhancement of TRPC6-mediated Zn2+ influx prevents chronic heart failure progression in mice. Our data demonstrate that TRPC6-mediated Zn2+ influx with α1AR stimulation enhances baroreflex-induced positive inotropy, which may be a new therapeutic strategy for chronic heart failure.

    DOI： 10.1038/s41467-022-34194-9

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  • High hydrostatic pressure induces slow contraction in mouse cardiomyocytes. Reviewed International journal

    Yohei Yamaguchi, Masayoshi Nishiyama, Hiroaki Kai, Toshiyuki Kaneko, Keiko Kaihara, Gentaro Iribe, Akira Takai, Keiji Naruse, Masatoshi Morimatsu

    Biophysical journal   2022.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    Cardiomyocytes are contractile cells that regulate heart contraction. Ca2+ flux via Ca2+ channels activates actomyosin interactions, leading to cardiomyocyte contraction, which is modulated by physical factors (e.g., stretch, shear stress, and hydrostatic pressure). We evaluated the mechanism triggering slow contractions using a high-pressure microscope to characterize changes in cell morphology and intracellular Ca2+ concentration ([Ca2+]i) in mouse cardiomyocytes exposed to high hydrostatic pressures. We found that cardiomyocytes contracted slowly without an acute transient increase in [Ca2+]i, while a myosin ATPase inhibitor interrupted pressure-induced slow contractions. Furthermore, transmission electron microscopy showed that, although the sarcomere length was shortened upon the application of 20 MPa, this pressure did not collapse cellular structures such as the sarcolemma and sarcomeres. Our results suggest that pressure-induced slow contractions in cardiomyocytes are driven by the activation of actomyosin interactions without an acute transient increase in [Ca2+]i.

    DOI： 10.1016/j.bpj.2022.07.016

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  • Ectopic expression of a rice plasma membrane intrinsic protein (OsPIP1;3) promotes plant growth and water uptake. Reviewed International journal

    Siyu Liu, Tatsuya Fukumoto, Patrizia Gena, Peng Feng, Qi Sun, Qiang Li, Tadashi Matsumoto, Toshiyuki Kaneko, Hang Zhang, Yao Zhang, Shihua Zhong, Weizhong Zeng, Maki Katsuhara, Yoshichika Kitagawa, Aoxue Wang, Giuseppe Calamita, Xiaodong Ding

    The Plant journal : for cell and molecular biology   102 ( 4 )   779 - 796   2020.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    Plasma membrane intrinsic proteins (PIPs) are known to be major facilitators of the movement of a number of substrates across cell membranes. From a drought-resistant cultivar of Oryza sativa (rice), we isolated an OsPIP1;3 gene single-nucleotide polymorphism (SNP) that is mostly expressed in rice roots and is strongly responsive to drought stress. Immunocytochemistry showed that OsPIP1;3 majorly accumulated on the proximal end of the endodermis and the cell surface around the xylem. Expression of GFP-OsPIP1;3 alone in Xenopus oocytes or rice protoplasts showed OsPIP1;3 mislocalization in the endoplasmic reticulum (ER)-like neighborhood, whereas co-expression of OsPIP2;2 recruited OsPIP1;3 to the plasma membrane and led to a significant enhancement of water permeability in oocytes. Moreover, reconstitution of 10×His-OsPIP1;3 in liposomes demonstrated water channel activity, as revealed by stopped-flow light scattering. Intriguingly, by patch-clamp technique, we detected significant NO3 - conductance of OsPIP1;3 in mammalian cells. To investigate the physiological functions of OsPIP1;3, we ectopically expressed the OsPIP1;3 gene in Nicotiana benthamiana (tobacco). The transgenic tobacco plants exhibited higher photosynthesis rates, root hydraulic conductivity (Lpr ) and water-use efficiency, resulting in a greater biomass and a higher resistance to water deficit than the wild-type did. Further experiments suggested that heterologous expression of OsPIP1;3 in cyanobacterium altered bacterial growth under different conditions of CO2 gas supply. Overall, besides shedding light on the multiple functions played by OsPIP1;3, this work provides insights into the translational value of plant AQPs.

    DOI： 10.1111/tpj.14662

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  • TRPC3 participates in angiotensin II type 1 receptor-dependentstress-induced slow increase in intracellular Ca2+concentrationin mouse cardiomyocytes Reviewed

    Yohei Yamaguchi, Gentaro Iribe, Toshiyuki Kaneko, Ken Takahashi, Takuro Numaga-Tomita, Motohiro Nishida, Lutz Birnbaumer, Keiji Naruse

    The Journal of Physiological Sciences   2018.3

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  • Addition of urea and thiourea to electrophoresis sample buffer improves efficiency of protein extraction from TCA/acetone-treated smooth muscle tissues for phos-tag SDS-PAGE Reviewed International journal

    Kosuke Takeya, Toshiyuki Kaneko, Motoi Miyazu, Akira Takai

    Electrophoresis   39 ( 2 )   326 - 333   2018.1

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Wiley-VCH Verlag  

    DOI： 10.1002/elps.201700394

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  • Dynamic Regulation of the Root Hydraulic Conductivity of Barley Plants in Response to Salinity/Osmotic Stress Reviewed

    Toshiyuki Kaneko, Tomoaki Horie, Yoshiki Nakahara, Nobuya Tsuji, Mineo Shibasaka, Maki Katsuhara

    PLANT AND CELL PHYSIOLOGY   56 ( 5 )   875 - 882   2015.5

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    DOI： 10.1093/pcp/pcv013

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  • Load dependency in force-length relations in isolated single cardiomyocytes Reviewed International journal

    Gentaro Iribe, Toshiyuki Kaneko, Yohei Yamaguchi, Keiji Naruse

    PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY   115 ( 2-3 )   103 - 114   2014.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.pbiomolbio.2014.06.005

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  • CO2 Transport by PIP2 Aquaporins of Barley Reviewed

    Izumi C. Mori, Jiye Rhee, Mineo Shibasaka, Shizuka Sasano, Toshiyuki Kaneko, Tomoaki Horie, Maki Katsuhara

    PLANT AND CELL PHYSIOLOGY   55 ( 2 )   251 - 257   2014.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/pcp/pcu003

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  • Aquaporin OsPIP1;1 promotes rice salt resistance and seed germination Reviewed

    Chengwei Liu, Tatsuya Fukumoto, Tadashi Matsumoto, Patrizia Gena, Daniele Frascaria, Tomoyuki Kaneko, Maki Katsuhara, Shihua Zhong, Xiaoli Sun, Yanming Zhu, Ikuko Iwasaki, Xiaodong Ding, Giuseppe Calamita, Yoshichika Kitagawa

    PLANT PHYSIOLOGY AND BIOCHEMISTRY   63   151 - 158   2013.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.plaphy.2012.11.018

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  • Improvement in Carbon Fiber Technique for Cardiomyocyte Mechanics and Mechano-Electric Coupling Study

    Iribe Gentaro, Kaneko Toshiyuki, Yamaguchi Yohei, Kaihara Keiko, Naruse Keiji

    BME   51   M - 32-M-32   2013

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    Language：English   Publisher：Japanese Society for Medical and Biological Engineering  

    DOI： 10.11239/jsmbe.51.M-32

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  • K+ Transport by the OsHKT2;4 Transporter from Rice with Atypical Na+ Transport Properties and Competition in Permeation of K+ over Mg2+ and Ca2+ Ions Reviewed International journal

    Tomoaki Horie, Dennis E. Brodsky, Alex Costa, Toshiyuki Kaneko, Fiorella Lo Schiavo, Maki Katsuhara, Julian I. Schroeder

    PLANT PHYSIOLOGY   156 ( 3 )   1493 - 1507   2011.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1104/pp.110.168047

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  • Mechanisms of Water Transport Mediated by PIP Aquaporins and Their Regulation Via Phosphorylation Events Under Salinity Stress in Barley Roots Reviewed

    Tomoaki Horie, Toshiyuki Kaneko, Genki Sugimoto, Shizuka Sasano, Sanjib Kumar Panda, Mineo Shibasaka, Maki Katsuhara

    PLANT AND CELL PHYSIOLOGY   52 ( 4 )   663 - 675   2011.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/pcp/pcr027

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  • Membrane Stretching Triggers Mechanosensitive Ca2+ Channel Activation in Chara Reviewed

    Toshiyuki Kaneko, Naoya Takahashi, Munehiro Kikuyama

    JOURNAL OF MEMBRANE BIOLOGY   228 ( 1 )   33 - 42   2009.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s00232-009-9156-6

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  • Mechanosensitive ion channels in chara: influence of water channel inhibitors, HgCl2 and ZnCl2, on generation of receptor potential. Reviewed International journal

    Kosei Iwabuchi, Toshiyuki Kaneko, Munehiro Kikuyama

    The Journal of membrane biology   221 ( 1 )   27 - 37   2008.1

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    Characean internodal cells generate receptor potential (DeltaE (m)) in response to mechanical stimuli. Upon a long-lasting stimulus, the cells generated DeltaE (m) at the moment of both compression and decompression, and the amplitude of DeltaE (m) at the moment of decompression, (DeltaE (m))(E), was larger than that at compression. The long-lasting stimulus caused a membrane deformation (DeltaD (m)) having two components, a rapid one, (DeltaD (m))(rapid), at the moment of compression and a slower one, (DeltaD (m))(slow), during the long-lasting compression. We assumed that (DeltaD (m))(slow) might have some causal relation with the larger DeltaE (m) at (DeltaE (m))(E). We treated internodal cells with either HgCl(2) or ZnCl(2), water channel inhibitors, to decrease (DeltaD (m))(slow). Both inhibitors attenuated (DeltaD (m))(slow) during compression. Cells treated with HgCl(2) generated smaller (DeltaE (m))(E) compared to nontreated cells. On the other hand, cells treated with ZnCl(2) never attenuated (DeltaE (m))(E) but, rather, amplified it. Thus, the amplitude of (DeltaD (m))(slow) did not always show tight correlation with the amplitude of (DeltaE (m))(E). Furthermore, when a constant deformation was applied to an internodal cell in a medium with higher or lower osmotic value, a cell having higher turgor always showed a larger (DeltaE (m))(E). Thus, we concluded that changes in tension at the membrane may be the most important factor to induce activation of mechanosensitive Ca(2+) channel.

    DOI： 10.1007/s00232-007-9082-4

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  • Ionic mechanism of mechano-perception in Characeae. Reviewed

    Kosei Iwabuchi, Toshiyuki Kaneko, Munehiro Kikuyama

    Plant & cell physiology   46 ( 11 )   1863 - 71   2005.11

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    Characean internodal cells generate receptor potential in response to mechanical stimuli. We studied responses of internodal cells to a long-lasting stimulus and the results were as follows. (i) The cell generated receptor potential at the moment of both compression and decompression. (ii) The receptor potential (DeltaE (m)) was significantly larger at the moment of decompression than at compression. (iii) The longer the duration of the stimulus, the larger was the magnitude of DeltaE (m) at the moment of decompression. (iv) Aequorin studies revealed that the increase in [Ca(2+)](c) (Delta[Ca(2+)](c)) took place at the moment of both compression and decompression. (v) The amplitude of Delta[Ca(2+)](c) was larger at the moment of decompression than at compression, as was the case for DeltaE (m). It was suggested that the amplitude of the receptor potential had a tight correlation with the degree of membrane deformation. We discussed the ionic mechanism of mechano-perception under a long-lasting stimulus in relation to mechanosensitive activation of Ca(2+) channels at the plasma membrane.

    DOI： 10.1093/pcp/pci204

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  • Possible involvement of mechanosensitive Ca2+ channels of plasma membrane in mechanoperception in Chara Reviewed

    T Kaneko, C Saito, T Shimmen, M Kikuyama

    PLANT AND CELL PHYSIOLOGY   46 ( 1 )   130 - 135   2005.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/pcp/pci004

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MISC

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Presentations

  • 高齢期マウスの瞳孔径調節におけるTRPCチャネルノックアウトの影響

    金子智之, 山口陽平, 高井章

    第64回日本平滑筋学会総会 

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    Event date： 2022.7

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  • マウス眼内平滑筋におけるTRPCノックアウトの対光反射に与える影響

    金子智之, 竹谷浩介, 宮津基, 高井章

    第95回日本生理学会大会 

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    Event date： 2018.3

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  • 単離心筋細胞への高伸展刺激時における負荷依存性

    金子智之, 成瀬恵治, 入部玄太郎

    日本生理学会北海道地方会 

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    Event date： 2015.9

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  • CO2 Permeability of PIP2 Aquaporins International conference

    Izumi C. Mori, Jiye Rhee, Mineo Shibasaka, Shizuka Sasano, Toshiyuki Kaneko, Tomoaki Horie, Maki Katsuhara

    Plant Biology 

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    Event date： 2014.7

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  • Improvement in Carbon Fiber Technique for Cardiomyocyte Mechanics and Mechano-Electric Coupling Study. International conference

    Gentaro Iribe, Toshiyuki Kaneko, Yohei Yamaguchi, Keiko Kaihara, Keiji Naruse

    35th Annual International IEEE EMBS Conference 

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    Event date： 2013.7

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  • Root hydraulic conductivity and PIP aquaporins of barley and rice in response to salinity/osmotic stress. International conference

    Maki Katsuhara, Toshiyuki Kaneko, Tomoaki Horie, Nobuya Tsuji, Mineo Shibasaka

    International Workshop on Plant Membrane Biology XVI 

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    Event date： 2013.3

    Language：English   Presentation type：Oral presentation (general)  

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  • HKT transporter-mediated K+ homeostasis in Oryza sativa plants International conference

    Horie, T., Brodsky, DE, Costa, A., Kaneko, T., Katsuhara, M., Schroeder, JI

    3rd Japan-China Joint Workshop on Plant Nutrition 

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    Event date： 2011.3

    Language：English   Presentation type：Symposium, workshop panel (nominated)  

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  • Regulation of Root Water Permeability in Barley under Salt Stress International conference

    M. Katsuhara, T. Kaneko, T. Horie, M. Shibasaka

    Gordon Research Conference - Salt & Water Stress In Plants 

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    Event date： 2009.6

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  • PIP Aquaporins and Water Relations in Barley Roots under Salt Stress International conference

    M. Katsuhara, G. C. Chung, G. Sugimoto, J. Y. Rhee, T. Kaneko, T. Horie

    Gordon Research Conference - Salt & Water Stress In Plants 

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    Event date： 2008.9

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  • Transcriptional Regulations and Water Transport Activity of PIP-type Aquaporins in Roots of Barley International conference

    T. Horie, G. Sugimoto, T. Kaneko, M. Shibasaka, M. Katsuhara

    Gordon Research Conference - Salt & Water Stress In Plants 

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    Event date： 2008.9

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  • 車軸藻の機械刺激感受には機械刺激感受性カルシウムチャンネルが関わっている

    金子智之, 齋藤千幸, 新免輝男, 菊山宗弘

    日本植物学会北陸支部会 

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    Event date： 2004.6

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  • 刺激受容への機械刺激感受性カルシウムチャネルの関与

    金子智之, 齋藤千幸, 新免輝男, 菊山宗弘

    日本植物学会第67回大会 

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    Event date： 2003.3

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  • マウス眼内平滑筋の対光反射におけるTRPCノックアウトの影響

    第59回日本平滑筋学会総会  2017.8 

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    Language：Japanese   Presentation type：Poster presentation  

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  • Influence on light reflex of TRPC knockout on mouse intraocular smooth muscle

    Kaneko Toshiyuki

    2018.3 

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  • Influence of TRPC knockout on mouse pupillary sphincter

    2019.3 

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  • マウス眼内平滑筋に対するTRPCノックアウトの影響

    第61回日本平滑筋学会総会  2019.8 

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  • 瞳孔径調節におけるTRPCノックアウトの影響

    第97回日本生理学会大会  2020.3 

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  • 単離心筋細胞の高伸展刺激時における負荷依存性

    第95回北海道医学会生理系分科会  2015.9 

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  • 刺激受容への機械刺激感受性カルシウムチャネルの関与

    日本植物学会第67回大会  2003.9 

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  • 車軸藻の機械刺激感受には機械刺激感受性カルシウムチャネルが関わっている

    日本植物学会北陸支部会  2004.6 

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  • 高浸透圧ストレス下におけるオオムギ根の水輸送活性制御機構の解明

    第51回日本植物生理学会  2010.3 

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  • シャジクモ類の機械刺激感受性カルシウムチャネルに膜の伸展が与える影響

    第47回日本植物生理学会  2006.3 

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  • シャジクモ類の機械刺激感受性カルシウムチャネルにおける膜伸展の影響

    第48回日本植物生理学会  2007.3 

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  • オオムギ根における水透過性測定のためのpressure chamber作製と測定法の確立

    第28回根研究集会  2008.5 

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  • 塩ストレス条件下におけるオオムギ根の水透過性

    第29回根研究集会  2008.11 

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  • オオムギ根の水輸送活性は塩ストレス下において翻訳後修飾によって抑制されている

    第50回日本植物生理学会  2009.3 

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  • Dynamic regulation of the root hydraulic conductivity of barley plants under salinity/osmotic stress International conference

    Kaneko Toshiyuki

    The JSRR's 20th Anniversary Symposium, The Latest Frontiers of Root Research in Asia  2011.11 

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  • Dynamic regulation of root hydraulic conductivity and aquaporins under salt stress International conference

    Kaneko Toshiyuki

    International Symposium "Strategies of Plants against Global Environmental Change"  2011.12 

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  • Development of advanced stretch system for single isolated cardiomyocyte

    Kaneko Toshiyuki

    2012.5 

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  • A novel cardiomyocyte stretch system for single cell mechanics study under physiological loading condition International conference

    Kaneko Toshiyuki

    World Congress 2012 Medical Physics and Biomedical Engineering  2012.5 

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  • 機械刺激とカルシウムシグナル Invited

    日本植物学会第76回大会植物生体膜シンポジウム  2012.9 

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  • 単離心筋細胞への高伸展刺激時における負荷依存性

    第65回日本生理学会中国四国地方会  2013.11 

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  • 単離心筋細胞への高伸展刺激負荷のための新たな細胞保持系の確立

    第34回日本生体医工学会中国四国支部大会  2011.10 

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Awards

  • 日本生体医工学会中国四国支部大会若手奨励賞

    2011.10   日本生体医工学会  

    金子智之

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    Award type：Award from Japanese society, conference, symposium, etc.  Country：Japan

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Research Projects

  • 隣接細胞における心筋死細胞認識シグナルの解明

    Grant number：24K15718  2024.4 - 2027.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    金子 智之, 山口陽平

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    Grant amount：\4,680,000 （ Direct Cost: \3,600,000 、 Indirect Cost：\1,080,000 ）

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  • Analyses of the interaction between blood pressure-derived mechano-stress and cardiomyocyte dynamics.

    Grant number：23K11800  2023.4 - 2026.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Grant amount：\4,680,000 （ Direct Cost: \3,600,000 、 Indirect Cost：\1,080,000 ）

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  • 心筋機械感受性制御におけるROSシグナリングの役割とその心不全治療への展開

    Grant number：21K12640  2021.4 - 2024.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    入部 玄太郎, 山口 陽平, 貝原 恵子, 金子 智之

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    Grant amount：\4,290,000 （ Direct Cost: \3,300,000 、 Indirect Cost：\990,000 ）

    本年度は、単離心筋細胞で観察される伸展誘発性ROS産生増加による筋小胞体カルシウムハンドリングの修飾がどのように心筋メカニクスに影響しているかを、野生型およびNOX2ノックアウト（KO）マウス心筋細胞の伸展誘発性カルシウムトランジェント変化、心筋細胞長さ張力関係による力学解析から検討した。
    その結果、心筋細胞の収縮性の指標となる収縮期末長さ張力関係の傾き（最大弾性率）は野生型に比べてNOX2KOマウスでは有意に低下していた。伸展によるカルシウムトランジェント波形は野生型のマウス心筋細胞では変化が無かったが、NOX2KOマウス心筋細胞においては細胞内カルシウム濃度の上昇率が最大に達するまでの時間が伸展によって有意に遅延することが明らかとなった。
    NOX2はリアノジン受容体を刺激することが知られているが、このカルシウムトランジェントの変化がNOX2による伸展誘発性ROS産生の有無によって説明ができるのか、また、この変化がNOX2KOマウス心筋の収縮性低下を説明できるのかをコンピュータシミュレーションによって検討した。心筋細胞数理モデルとしてIribe-Kohl-Nobleモデルを用いた。このリアノジン受容体モデルの活性化レートを上げ、同時にリアノジン受容体からのカルシウムリーク率を上げることでNOX2がリアノジン受容体に及ぼす影響を再現した。前者はカルシウムトランジェントの立ち上がりをやや早め、ピークを上昇させるが、後者はピークを減弱させる効果があり、結果としてピークは変わらず立ち上がりの早いトランジェント波形となった。また、前者は発生張力を増加させる効果があり、後者は発生張力をわずかに減少させる効果があるがその効果は弱く、結果的に収縮力は増加することとなり、細胞実験の結果を再現することができた。

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  • 眼内平滑筋収縮の持続相におけるカルシウムイオン流入メカニズムの解明

    2017.4 - 2019.3

    日本学術振興会  若手研究(B) 

    金子 智之

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    Authorship：Principal investigator  Grant type：Competitive

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