Updated on 2025/06/06

写真a

 
HIROFUJI Aina
 
Organization
School of Medicine Medical Course Clinical Medicine Surgery [Division of Cardiovascular Surgery]
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Education

  • Kurume University   Faculty of Medicine

    - 2017.3

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    Country: Japan

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Papers

  • Current Practices for Cohort Reporting and Statistical Adjustment in Studies From The Society of Thoracic Surgeons Adult Cardiac Surgery Database. International journal

    Polina Mantaj, Irbaz Hameed, Aina Hirofuji, Michele Dell'Aquila, Mohamed Rahouma, Shadi Abdalla, Moira Kennedy, Alexander Gregg, Camilla S Rossi, Giovanni Soletti, Giorgia Falco, Mary Charlson, Sigrid Sandner, Thomas A Schwann, Mario Gaudino

    The Annals of thoracic surgery   2025.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Current reporting and statistical adjustment practices of studies based on The Society of Thoracic Surgeons Adult Cardiac Surgery Database (STS ACSD) have not been described. METHODS: A review identified all published studies based on STS ACSD data from January 2016 to May 2024. Data were extracted by 2 authors and independently checked by the senior author. RESULTS: A total of 134 studies were included. There were 46 (34.3%) studies on coronary artery bypass grafting, 22 (16.4%) on mitral valve surgery, 16 (11.9%) on aortic surgery, 14 (10.4%) on surgical aortic valve replacement, 3 (2.2%) on tricuspid valve surgery, 18 (13.4%) on combined procedures, and 15 (11.2%) on other interventions; 59 (44.0%) studies used the Participant User File (PUF) program, with a significant increase over time (Ptrend = .005). Of the 1239 variables available in the STS ACSD (version 4.20.2), 136 (11.0%; median, 21 variables per study; interquartile range [IQR], 16-25) were used to describe the baseline characteristics of the patients and 191 (15.4%; median, 22 variables per study; IQR, 17-33) for statistical adjustment; 121 studies (90.3%) performed statistical adjustment, with multivariable regression used in most (80 [66.1%]). PUF manuscripts had significantly more junior first authors (20.3% vs 1.3%; P = .001) and were published in higher impact journals (median impact factor, 4.90 [IQR, 3.70-9.15] vs 3.90 [IQR, 3.60-4.70]; P = .002) compared with non-PUF manuscripts. CONCLUSIONS: Our analysis provides data that may inform efforts to standardize reporting and analytic practices in studies based on the STS ACSD.

    DOI: 10.1016/j.athoracsur.2025.02.011

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  • Hypothermic circulatory arrest at 20 ℃ does not deteriorate coagulopathy compared to 28 ℃ in a pig model.

    Hayato Ise, Kyohei Oyama, Ryohei Ushioda, Aina Hirofuji, Keisuke Kamada, Yuri Yoshida, Payam Akhyari, Hiroyuki Kamiya

    Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs   28 ( 1 )   36 - 42   2025.3

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    It is believed that a lower temperature setting of hypothermic circulatory arrest (HCA) in thoracic aortic surgery causes coagulopathy, resulting in excessive bleeding. However, experimental studies that eliminate clinical factors are lacking. The objective of this study is to investigate the influence of the temperature setting of HCA on coagulation in a pig model. Ten pigs were divided into the following two groups: moderate temperature at 28 °C (group M, n = 5) or lower temperature at 20 °C (group L, n = 5). Two hours of HCA during a total of 4 h of cardiopulmonary bypass (CPB) were performed. Blood samples were obtained at the beginning (T1) and the end (T2) of the surgery, and coagulation capability was analyzed through standard laboratory tests (SLTs) and rotational thromboelastometry (ROTEM). In SLTs, hemoglobin, fibrinogen, platelet count, prothrombin time, and activated partial thromboplastin time were analyzed. In ROTEM analyses, clotting time and clot formation time of EXTEM, maximum clot firmness (MCF), and maximum clot elasticity (MCE) of EXTEM and FIBTEM were analyzed. Fibrinogen decreased significantly in both groups (group M, p = 0.008; group L, p = 0.0175) at T2, and FIBTEM MCF and MCE also decreased at T2. There were no differences regarding changes in parameters of SLTs and ROTEM between groups. CPB decreases coagulation capacity, contributed by fibrinogen. However, a lower temperature setting of HCA at 20 °C for 2 h did not significantly affect coagulopathy compared to that of HCA at 28 °C after re-warming to 37 °C.

    DOI: 10.1007/s10047-024-01449-9

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  • Predictors of premature termination of cardiac surgery trials: insights from the Clinicaltrial.gov database. International journal

    Gianmarco Cancelli, Camilla S Rossi, Michele Dell'Aquila, Polina Mantaj, Aina Hirofuji, Giovanni Soletti, Lamia Harik, Busra Cangut, Talal Al Zaghari, Jordan Leith, Giorgia Falco, Mudathir Ibrahim, Arnaldo Dimagli, Mohamed Rahouma, Mario F L Gaudino

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery   66 ( 2 )   2024.8

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    OBJECTIVES: Clinical trials that are terminated prematurely may generate incomplete and potentially biased data and the reasons for premature trials termination are poorly understood. Our objective was to describe the incidence of premature trial termination and identify factors associated with it. METHODS: We performed a systematic search on ClinicalTrials.gov to identify all cardiac surgery trials from 1991 to 2023. Trials that were terminated prematurely were identified. Factors independently associated with premature termination were identified using multivariable logistic regression analysis. RESULTS: A total of 746 clinical trials were included; of them 577 were completed and 169 (22.6%) were terminated prematurely. Most of the trials originated from North America [294 (39.4%)], Europe [264 (35.4%)] or Asia [141 (18.9%)]. Fourteen of the trials terminated prematurely (8.3%) were phase 1, 75 (44.4%) phase 2, 49 (29.0%) phase 3 and 31 (18.3%) phase 4. Fifty (29.6%) trials were terminated because of slow recruitment, 20 (11.8%) because of sponsor decision and 12 (7.1%) because of lack of funding. Left ventricular assist device trials [odds ratio (OR) 3.65, 95% confidence interval (CI) (1.65-8.00) P = 0.001], valve surgery trials [OR 4.30, 95% CI (2.33-8.00) P < 0.001], aortic surgery trials [OR 2.86 95% CI (1.22-6.43) P = 0.012], phase 2 [OR 3.02, 95% CI (1.31-7.93) P = 0.015] and phase 4 trials [OR 3.62, 95% CI (1.43-10.23) P = 0.010] were at higher risk of premature termination while trials performed in Asia [OR 0.18, 95% CI (0.07-0.39) P ≤ 0.001] and Europe [OR 0.49, 95% CI (0.30-0.80) P = 0.004] were less likely to be terminated prematurely. CONCLUSIONS: Slow recruitment is the most common reason for premature termination of cardiac surgery trials. Trials on left ventricular assist device, valve surgery, aortic surgery, phase 2 trials and phase 4 trials are more likely to be terminated, while trials conducted in Asia and Europe are less likely to be terminated prematurely.

    DOI: 10.1093/ejcts/ezae310

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  • 心筋再生治療を目指して:Mycによる心筋細胞分裂誘導と心筋梗塞後の心機能保護

    53 ( 3 )   vii - viii   2024.5

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    Authorship:Lead author   Publishing type:Research paper (other academic)   Publisher:The Japanese Society for Cardiovascular Surgery  

    DOI: 10.4326/jjcvs.53.3.vii

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  • Fulminant respiratory failure due to severe pneumothorax after re-do coronary artery bypass grafting treated with veno-venous extracorporeal membrane oxygenation. International journal

    Akito Inoue, Ryohei Ushioda, Kazuki Miyatani, Kentaro Shirakura, Nobuhiro Mochizuki, Hideki Isa, Yuki Setogawa, Masahiko Narita, Fumitaka Suzuki, Aina Hirofuji, Ryo Okubo, Shingo Kunioka, Masahiro Tsutsui, Kamiya Hiroyuki

    Journal of surgical case reports   2024 ( 5 )   rjae360   2024.5

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    This case report details the management of a 79-year-old man who developed massive postoperative pneumothorax following redo coronary artery bypass grafting due to severe lung adhesions. We successfully treated the patient using veno-venous extracorporeal membrane oxygenation without femoral cannulation, allowing for early rehabilitation initiation. Veno-venous extracorporeal membrane oxygenation is a reasonable option for cases of severe respiratory failure due to pneumothorax with lung destruction caused by re-sternotomy during re-do cardiac surgery.

    DOI: 10.1093/jscr/rjae360

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  • A case of non-bacterial thrombotic endocarditis on the aortic valve following coronary angiography. International journal

    Nobuhiro Motiduki, Ryohei Ushioda, Sayaka Yuzawa, Kazuki Miyatani, Hideki Isa, Yuki Setogawa, Kohei Ishidou, Masahiko Narita, Fumitaka Suzuki, Aina Hirofuji, Ryo Okubo, Shingo Kunioka, Masahiro Tsutsui, Natsuya Ishikawa, Kamiya Hiroyuki

    Journal of surgical case reports   2024 ( 4 )   rjae212   2024.4

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    Nonbacterial thrombotic endocarditis (NBTE) on the aortic valve involves fibrin and platelet aggregate formation, potentially leading to embolic events. We present a case of NBTE on the aortic valve following coronary angiography (CAG) in a 54-year-old man with multiple comorbidities. Surgical thrombectomy was performed owing to acute cerebral infarcts. This case highlights the significance of considering that mechanical trauma from catheterization during CAG can trigger thrombus formation.

    DOI: 10.1093/jscr/rjae212

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  • [Early Outcomes and Indications for Surgical Intervention of Preoperative Atrial Fibrillation].

    Hideki Isa, Kazuki Miyatani, Nobuhiro Mochizuki, Fumitaka Suzuki, Yuki Setogawa, Aina Hirofuji, Shingo Kunioka, Masahiro Tsutsui, Natsuya Ishikawa, Hiroyuki Kamiya

    Kyobu geka. The Japanese journal of thoracic surgery   77 ( 1 )   4 - 8   2024.1

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    BACKGROUND: This study investigates short-term outcomes following surgical interventions for atrial fibrillation (Af), including the Cox-maze Ⅳ procedure (maze procedure) and pulmonary vein isolation (PVI), performed concurrently with other cardiac surgeries. Additionally, we aim to determine the indications for surgical intervention for Af. METHOD: We retrospectively studied a total of 1,580 patients, out of which 274 had preoperative Af, that underwent cardiac surgery between January 2015 and April 2023. Patients who underwent emergency surgery, died in the hospital postoperatively, or received pacemaker implantation were excluded. Patients were first divided into two groups:the intervention group (n=135, 53.6%) and the non-intervention group( n=117, 46.4%), further categorized by whether they were in sinus rhythm at discharge. The intervention group was then subdivided into the maze procedure group( n=54), and the PVI group (n=76). RESULTS: Within the maze procedure group, significant differences were observed between the sinus rhythm and non-sinus rhythm groups in terms of age, preoperative Af duration, and aortic valve intervention status. In the PVI group, patients with persistent Af, longer preoperative Af duration, and larger left atrium diameter( LAD) were less likely to return to sinus rhythm. Smaller LAD was also a significant factor for returning to sinus rhythm in the non-intervention group. Multivariate analysis for all patients revealed that an LAD smaller than 50 mm was the strongest predictor for returning to sinus rhythm post operation( p<0.01). CONCLUSION: For patients with persistent Af, the maze procedure is favored over PVI as a surgical intervention. When LAD exceeds 50 mm, the likelihood of returning to sinus rhythm is diminished.

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  • Minimally invasive cardio surgery for the patient with tracheostoma who has severe mitral valve regurgitation

    Inoue Akito, Miyatani Kazuki, Isa Hideki, Suzuki Humitaka, Setogawa Yuki, Ookubo Ryo, Hirohuji Aina, Kunioka Shingo, Tsutsui Masahiro, Ishikawa Natsuya, Kamiya Hiroyuki

    The Hokkaido Journal of Surgery   69 ( 1 )   30 - 34   2024

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    Language:Japanese   Publisher:Hokkaido Surgical Society  

    Minimally invasive cardiac surgery (MICS) is a helpful technique when you have to perform cardiac surgery for a patient with chronic tracheostomy. To avoid risk of sternal wound infection and mediastinitis, MICS may be a safer approach than medial sternotomy for tracheostomy patients. Here, we present a septuagenarian male patient. He was diagnosed with acute heart failure due to mitral valve regurgitation (MR) with such deteriorating general condition that a tracheostomy was necessary. After transfer to our hospital, Mitral Clip was performed for his MR, after which, he developed a fever from suspected infectious endocarditis (IE). We ultimately performed minimally invasive mitral valve plasty to eliminate the MR and treat the IE, without post operational complications.

    DOI: 10.60440/hokkaidojsurg.69.1_30

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    Other Link: https://ndlsearch.ndl.go.jp/books/R000000004-I033684816

  • Off-pump minimally invasive coronary artery bypass grafting in patients with left ventricular dysfunction: the lampang experience. International journal

    Ryohei Ushioda, Aina Hirofuji, Dit Yoongtong, Boonsap Sakboon, Jaroen Cheewinmethasiri, Hiroyuki Kamiya, Nuttapon Arayawudhikul

    Frontiers in surgery   11   1324343 - 1324343   2024

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    INTRODUCTION: The minimally invasive cardiac surgery off-pump coronary artery bypass (MICSOPCAB) is technically difficult; therefore, previous studies have indicated that MICSOPCAB should be contraindicated in patients with impaired left ventricular (LV) function. In this study, we investigated the feasibility of MICSOPCAB in patients with impaired LV function. METHODS: The 226 patients underwent MICSOPCAB between August 2017 and September 2022. Our study defined impaired LV function as ejection fraction (EF) in echocardiography 40% or less. The patients were divided into Low EF group (n = 39) and Normal EF group (n = 187). RESULTS: The Low EF group was in a more critical preoperative condition than Normal EF group (41.0% in the Low EF group vs. 14.4% in the Normal EF group; p < 0.001). For preoperative transthoracic echocardiography, LV end-diastolic diameter (5.5 ± 0.9 cm in the Low EF group vs. 5.0 ± 0.8 cm in the Normal EF group; p < 0.001) and LV end-systolic diameter (4.4 ± 1.0 cm in the Low EF group vs. 3.4 ± 1.0 cm in the Normal EF group; p < 0.001) were significantly larger in the Low EF group. No differences were found in the operative time (180 [160-240] min in the Low EF group vs. 205 [165-253] min in the Normal EF group; p = 0.231) and the median number of distal anastomoses (2 [1-2] in the Low EF group vs. 2 [1-3] in the Normal EF group; p = 0.073). Intensive care unit stay was longer in the Low EF group than in the Normal EF group (2 [1-2] in the Low EF group vs. 1 [1-2] in the Normal EF group; p = 0.010). Perioperative transfusion was more common in the Low EF group than in the Normal EF group (69.7% vs. 49.2%; p = 0.023). There were no differences in major complications, hospital stay, and 30-day mortality. The Kaplan-Meier curve showed no significant difference in postoperative major adverse cardiac or cerebrovascular events rates between the two groups (p = 0.185). CONCLUSION: In this study, MICSOPCAB can be performed in patients with low EF having short- and mid-term outcomes similar to patients with normal EF. Therefore, low EF should not be contraindicated in MICSOPCAB.

    DOI: 10.3389/fsurg.2024.1324343

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  • Multi-vessel coronary artery grafting: analyzing the minimally invasive approach and its safety. International journal

    Ryohei Ushioda, Aina Hirofuji, Dit Yoongtong, Boonsap Sakboon, Jaroen Cheewinmethasiri, Thanin Lokeskrawee, Jayanton Patumanond, Suppachai Lawanaskol, Hiroyuki Kamiya, Nuttapon Arayawudhikul

    Frontiers in cardiovascular medicine   11   1391881 - 1391881   2024

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    INTRODUCTION: At our institution, we perform off-pump coronary artery bypass (OPCAB) as a standard procedure. Moreover, patients with favorable coronary anatomy and condition are selected for minimally invasive cardiac surgery (MICS)-OPCAB. We retrospectively compared early outcomes, focusing on safety, between MICS-OPCAB and conventional off-pump techniques for multivessel coronary artery bypass grafting (CABG). METHODS: From August 2017 to September 2022, 1,220 patients underwent multivessel coronary artery grafting at our institution. They were divided into the MICS-OPCAB group (MICS group = 163 patients) and the conventional OPCAB group (MS group = 1057 patients). Propensity score matching (1 : 1 ratio) was applied to the MICS-OPCAB and MS groups (149 patients per group) based on 23 preoperative clinical characteristics. RESULTS: After matching, there were no significant differences in preoperative characteristics between the groups. The MICS group had a lower total graft number (2.3 ± 0.6 vs. 2.9 ± 0.8, p < 0.001) and fewer distal anastomoses (2.7 ± 0.8 vs. 3.2 ± 0.9, p < 0.001). There were no significant differences in hospital stay, intensive care unit stay, postoperative complications, and 30-day mortality. The MICS group had less drain output (MICS 350 ml [250-500], MS 450 ml [300-550]; p = 0.013). Kaplan-Meier analysis revealed no significant differences in postoperative MACCE (major adverse cardiac or cerebrovascular events)-free and survival rates between the groups (MACCE-free rate p = 0.945, survival rate p = 0.374). CONCLUSION: With proper patient selection, MICS-OPCAB can provide good short to mid-term results, similar to those of conventional OPCAB.

    DOI: 10.3389/fcvm.2024.1391881

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  • The left axillary artery is a reasonable option as the inflow site for saphenous vein graft in minimally invasive coronary artery bypass grafting. International journal

    Ryohei Ushioda, Aina Hirofuji, Dit Yoongtong, Boonsap Sakboon, Jaroen Cheewinmethasiri, Thanin Lokeskrawee, Jayanton Patumanond, Suppachai Lawanaskol, Hiroyuki Kamiya, Nuttapon Arayawudhikul

    Frontiers in cardiovascular medicine   11   1397396 - 1397396   2024

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    INTRODUCTION: This study aims to clarify the good inflow site for saphenous vein grafts (SVG) in minimally invasive off-pump coronary artery bypass grafting (mini-CABG), between the ascending aorta, the internal thoracic arteries (ITAs) and the left axillary artery (LAA). METHODS: This retrospective study included 126 patients who underwent Mini-CABG at our center between January 2014 and July 2023. Patients were divided into three groups according to the SVG inflow site for patency comparison: Aorta group (n = 56), LAA group (n = 23), and ITA group (n = 47). RESULTS: There were 84 males, with mean age of 65.9 ± 7.0 years. There were no significant differences in preoperative characteristics between groups. Mean operation times were 254.6 ± 72.2, 213.7 ± 57.6, and 253.0 ± 81.2 min, and the average numbers of distal anastomoses were 2.9 ± 0.9, 2.4 ± 0.7 and 2.9 ± 1.1 in the Aorta, ITA and LAA groups respectively. Days in intensive care, hospital stay, and major complications did not differ between the groups. Early patency of SVG did not significantly differ among groups: 93.0% in the Aorta group, 98.0% in the ITA group, and 100% in the LAA group. Mean follow-up period was 136.7 ± 295.7 days, and follow-up coronary CTA revealed 18 SVG occlusions (Aorta group n = 8, ITA group n = 5, LAA group n = 5). The Kaplan-Meier curve for SVG patency rates did not show any significant differences among the three groups. CONCLUSION: The ascending aorta, the ITAs, and the LAA serve as reliable inflow sites with similar results in mini-CABG.

    DOI: 10.3389/fcvm.2024.1397396

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  • Assessing the benefits of anaortic off-pump coronary artery bypass grafting. International journal

    Ryohei Ushioda, Aina Hirofuji, Dit Yoongtong, Boonsap Sakboon, Jaroen Cheewinmethasiri, Thanin Lokeskrawee, Jayanton Patumanond, Suppachai Lawanaskol, Hiroyuki Kamiya, Nuttapon Arayawudhikul

    Frontiers in cardiovascular medicine   11   1393921 - 1393921   2024

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    INTRODUCTION: The procedure called the "aorta no-touch" (NT) or anaortic technique in off-pump coronary artery bypass grafting (OPCAB) is designed to reduce the perioperative risk of stroke. We have observed an increased frequency of anaortic OPCAB procedures at our institution. The main purpose of the present study is to investigate the effectiveness of anaortic OPCAB in reducing the perioperative risk of stroke. METHODS: From April 2011 to July 2023, a total of 2,236 patients underwent isolated OPCAB at our single center. The patients were divided into the anaortic group (NT, n = 762) and the aortic group (A, n = 1,474). The NT group was propensity score-matched (PSM) with the A group at a 1:1 ratio (NT n = 640; A n = 640), and matching was performed based on 26 covariates with preoperative clinical characteristics. RESULTS: In both the unmatched and matched cohorts of the NT and A groups, there were no significant differences observed in new stroke rates (NT vs. A; unmatched, 1.0% vs. 1.2%, p = 0.624; matched, 0.9% vs. 1.3%, p = 0.789). The univariable logistic analysis did not identify the anaortic technique as an independent factor negatively associated with new stroke events (OR = 0.81, 95% CI = 0.35-1.86, p = 0.624). CONCLUSION: The present study did not find the anaortic technique to reduce the perioperative risk of stroke in OPCAB. Hence, further large studies are needed to identify patient cohorts in which anaortic OPCAB is significantly beneficial.

    DOI: 10.3389/fcvm.2024.1393921

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  • Two-stage repair for DeBakey type II acute aortic dissection and distal aortic arch aneurysm in a nonagenarian patient. International journal

    Kentaro Shirakura, Shingo Kunioka, Kazuki Miyatani, Nobuhiro Mochizuki, Hideki Isa, Yuki Setogawa, Fumitaka Suzuki, Ryo Okubo, Ryohei Ushioda, Aina Hirofuji, Masahiro Tsutsui, Natsuya Ishikawa, Hiroyuki Kamiya

    Journal of surgical case reports   2023 ( 12 )   rjad648   2023.12

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    Although total arch replacement would be performed in a patient with acute type A aortic dissection and concomitant aortic aneurysm in the distal aortic arch, total arch replacement may be too invasive in elderly patients with significant morbidities. A 92-year-old female with acute type II DeBakey aortic dissection and concomitant distal aortic arch aneurysm was successfully treated with hemi-arch replacement followed by thoracic endovascular aortic repair. Hybrid two-stage repair of DeBakey type II aortic dissection complicated by distal arch aneurysm using thoracic endovascular aortic repair after hemi-arch replacement may be effective.

    DOI: 10.1093/jscr/rjad648

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  • Interventional Bridging Therapy for Radical Cardiac Surgery in a Patient Seemed to be Inoperable Due to Very Poor Left Ventricular Function: A Case Report. International journal

    JeongA Lee, Masahiro Tsutsui, Nobuhiro Mochizuki, Yuki Setogawa, Fumitaka Suzuki, Masahiko Narita, Aina Hirofuji, Shingo Kunioka, Tomonori Shirasaka, Natsuya Ishikawa, Sayaka Yuzawa, Hiroyuki Kamiya

    The heart surgery forum   26 ( 6 )   E676-E679   2023.11

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    Cases that are inoperable owing to poor preoperative conditions are sometimes encountered. However, there are some cases that are led to radical treatment by performing bridge therapy. Here, we presented a case of a patient with complex cardiac disease in an inoperable state who underwent bridging therapy that led to successful surgical treatment. A 73-year-old male who received hemodialysis treatment and had severe aortic valve stenosis and coronary artery disease planned surgical treatment. However, he was deemed inoperable owing to his low cardiac function and hemodynamic instability. Therefore, to escape from a fatal condition, we first performed balloon aortic valvuloplasty and percutaneous coronary intervention as palliative procedures. Subsequently, his cardiac function and hemodynamic stability remarkably improved; therefore, after 1 month, we performed a successful radical surgical treatment. Even in inoperable patients, bridging therapy leading to radical treatment is possible.

    DOI: 10.59958/hsf.5779

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  • Evaluating Short-Term Postoperative Outcomes in Minimally Invasive Mitral Valve Surgery for Patients with Rheumatic Disease. International journal

    Ryohei Ushioda, Tomonori Shirasaka, Boonsap Sakboon, Jaroen Cheewinmethasiri, Dit Yoongtong, Aina Hirofuji, Hiroyuki Kamiya, Nuttapon Arayawudhikul

    The heart surgery forum   26 ( 2 )   E178-E182   2023.4

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    Minimally invasive mitral valve surgery (MIMVS) is widespread and has become a standard procedure in cardiac surgery [Chitwood 1997; Carpentier 1996]. Therefore, MIMVS is a common procedure for patients with degenerative disease [Raanani 2010; Iribarne 2010] as well. However, the safety of MIMVS in patients with rheumatic heart disease (RHD) has not thoroughly been investigated, due to the low prevalence of RHD in developed countries, where MIMVS is standardized [Miceli 2015]. Here, we investigated the safety of MIMVS for patients with RHD at Lampang Hospital in Thailand.

    DOI: 10.1532/hsf.5391

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  • 重症心疾患と末梢動脈疾患の重複症例に対する治療戦略 包括的高度慢性下肢虚血を合併する重症心疾患患者の予後予測に関する検討

    瀬戸川 友紀, 望月 伸浩, 鈴木 文隆, 成田 昌彦, 広藤 愛菜, 國岡 信吾, 筒井 真博, 白坂 知識, 石川 成津矢, 菊地 信介, 紙谷 寛之

    日本心臓血管外科学会学術総会抄録集   53回   75 - 75   2023.3

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  • Giant Coronary Aneurysm with Coronary-Pulmonary Artery Fistula in a Jehovah's Witness. International journal

    Aina Hirofuji, Azusa Furugen, Takeshi Kamada, Kenji Yamazaki, Hiroyuki Kamiya, Hirosato Doi

    The Thoracic and cardiovascular surgeon reports   12 ( 1 )   e1-e3   2023.1

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    With an incidence of 3 in 100 million, giant coronary artery aneurysm (CAA) with coronary artery fistula (CAF) is a very rare condition. To prevent rupture, giant CAA with CAF should be swiftly treated. We present a Jehovah's Witness patient with giant CAA and coronary-pulmonary artery fistula. We resected the giant CAA in one piece, while ligating the CAF, without allogeneic blood transfusion. Due to rarity of these conditions, many thoracic surgeons lack direct experience in its surgical procedures. Herein, we share footage of this surgery as an example of how to safely resect CAA with minimal bleeding.

    DOI: 10.1055/s-0042-1757877

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  • 急性心筋梗塞後のoozing rupture,乳頭筋断裂による僧帽弁閉鎖不全症と左室瘤に対してstaged therapyを行った1例

    福田 はな, 広藤 愛菜, 望月 伸浩, 瀬戸川 友紀, 鈴木 文隆, 成田 昌彦, 國岡 信吾, 筒井 真博, 白坂 知識, 石川 成津矢, 紙谷 寛之

    北海道外科雑誌   67 ( 2 )   196 - 197   2022.12

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  • ECG-gated helical CTを用いた術前大動脈弁輪径測定により大動脈弁置換術はより安全により迅速化できる

    白坂 知識, 望月 伸治, 瀬戸川 有紀, 成田 昌彦, 鈴木 文隆, 広藤 愛菜, 國岡 信吾, 筒井 真博, 石川 成津矢, 紙谷 寛之

    日本胸部外科学会定期学術集会   75回   OP1 - 1   2022.10

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    Language:Japanese   Publisher:(一社)日本胸部外科学会  

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  • Mitral valve replacement with papillary muscle tugging approximation in a patient with severely impaired left ventricular function 14 years after initial mitral valve repair. International journal

    Tomoki Nakatsu, Tomonori Shirasaka, Aina Hirofuji, Hiroyuki Kamiya

    Journal of surgical case reports   2022 ( 8 )   rjac339   2022.8

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    The best treatment for ventricular functional mitral regurgitation still remains unclear. Papillary muscle tugging approximation (PMTA) is a technique known to preserve function of the sub-valvular apparatus, keeping it functionally in synch with the left ventricle systolic and diastolic dynamics. Herein, we present a case of mitral valve replacement with PMTA in a patient with severely impaired left ventricular function 14 years post initial mitral valve repair, which significantly improved during a course of 4 years after the reoperation without any complications.

    DOI: 10.1093/jscr/rjac339

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  • Microvascular thrombi in recurrent myocardial injury after coronavirus disease 2019 infection. International journal

    Tadao Aikawa, Jiro Ogino, Aina Hirofuji, Noriko Oyama-Manabe

    European heart journal   42 ( 36 )   3804 - 3804   2021.9

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    DOI: 10.1093/eurheartj/ehab539

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  • Proximalized Total Arch Replacement Can Be Safely Performed by Trainee. International journal

    Sentaro Nakanishi, Naohiro Wakabayashi, Hayato Ise, Hiroto Kitahara, Aina Hirofuji, Natsuya Ishikawa, Hiroyuki Kamiya

    The Thoracic and cardiovascular surgeon   69 ( 4 )   336 - 344   2021.6

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    BACKGROUND: The aim of the present study was to validate safety of total arch replacement (TAR) using a novel frozen elephant trunk device, operated by trainees as surgical education. METHODS: Sixty-four patients including 19 patients (29.6%) with acute aortic dissection type A (AADA) underwent TAR in our institute between April 2014 and March 2019 were retrospectively analyzed. Twenty-nine patients were operated by trainees (group T) and 35 patients were operated by attending surgeons (group A). RESULTS: Patient characteristics did not differ between groups. Operative time (409.4 ± 87.8 vs. 468.6 ± 129.6 minutes, p = 0.034), cardiopulmonary bypass time (177.7 ± 50.4 vs. 222.9 ± 596.7 minutes, p = 0.019), and hypothermic circulatory arrest time (39.5 ± 13.4 vs. 54.5 ± 18.5 minutes, p = 0.001) were significantly shorter in group A than in group T, but aortic clamping time did not differ between groups (115.3 ± 55.7 vs. 114.2 ± 35.0 minutes, p = 0.924) because the rate of concomitant surgery was higher in group A (37.1 vs. 10.3%, p = 0.014). Thirty-day mortality was 3.1% in the entire cohort. Although operation time was longer in group T, there were no significant difference in postoperative results between the groups, and the experience levels of the main operator were not independent predictors for in-hospital mortality + major postoperative complications. There was no difference in late death and aortic events between groups. CONCLUSIONS: The present study demonstrated that TAR can be safely performed by trainees, and suggests TAR as a possible and safe educational operation.

    DOI: 10.1055/s-0040-1713354

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  • Rupture of aneurysmal coronary-to-pulmonary artery fistula in a 96-year-old female; report of a case.

    Haruka Murakami, Sentaro Nakanishi, Aina Hirofuji, Hiroyuki Kamiya

    General thoracic and cardiovascular surgery   69 ( 3 )   601 - 604   2021.3

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    Coronary artery fistula (CAF) is a relatively rare congenital abnormality of the coronary arteries; typically, patients who undergo surgery for CAFs are relatively young because it is a congenital disease. Here we present a case of an aneurysmal coronary-to-pulmonary artery fistula rupture in a 96-year-old female. Considering her extreme high age and missing preoperative diagnostics, only local hemostasis without anatomical repair was performed but the patient is still doing well 1 year after the operation.

    DOI: 10.1007/s11748-020-01488-y

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  • Awake Surgical Mitral Valve Repair after Transcatheter Aortic Valve Replacement. International journal

    Aina Hirofuji, Hirotsugu Kanda, Yuya Kitani, Hiroyuki Kamiya

    The Thoracic and cardiovascular surgeon reports   10 ( 1 )   e15-e17   2021.1

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    Transcatheter aortic valve replacement has become a popular choice for cases with severe aortic stenosis. However, when severe mitral regurgitation is comorbid in high-risk patients with severe aortic stenosis, therapeutic options must be weighed for each case. Here we present a very frail 88-year-old patient with severe aortic stenosis and severe mitral valve regurgitation who underwent a successful awake minimally invasive mitral valve repair after transcatheter aortic valve replacement.

    DOI: 10.1055/s-0040-1718774

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  • クラウド型遠隔医療システムにより速やかな診断が行われ、ステントグラフトを瘤内に留置することで治療できた胸腹部大動脈瘤破裂の1例

    高橋 一輝, 若林 尚宏, 石堂 耕平, 広藤 愛菜, 中西 仙太郎, 石川 成津矢, 古屋 敦宏, 東 信良, 紙谷 寛之

    北海道外科雑誌   65 ( 2 )   164 - 168   2020.12

  • Impella CP for treatment of left ventricular free-wall rupture after myocardial infarction: Report of a case. International journal

    Natsuya Ishikawa, Aina Hirofuji, Shingo Kunioka, Tomonori Shirasaka, Naohiro Wakabayashi, Yuya Kitani, Hiroyuki Kamiya

    Journal of surgical case reports   2020 ( 8 )   rjaa263   2020.8

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    Unloading of the left ventricle (LV) is essential for the treatment of LV free-wall rupture (LVFWR), and it is well-known that the LV can be optimally unloaded with the Impella system. However, there has been no report on applying the Impella system for the treatment of LVFWR. Here, we report a patient with FWR after massive myocardial infarction who was successfully treated with non-suture repair via median sternotomy and implantation of Impella CP (Abiomed, Danvers, MA).

    DOI: 10.1093/jscr/rjaa263

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  • Sutureless technique using the left atrial appendage for left pulmonary vein occlusion after catheter ablation. International journal

    Naohiro Wakabayashi, Aina Hirofuji, Natsuya Ishikawa, Hiroyuki Kamiya

    Surgical case reports   6 ( 1 )   179 - 179   2020.7

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    BACKGROUND: Pulmonary vein stenosis or occlusion is a rare but one of the most devastating complications after catheter ablation for cardiac arrhythmias, and surgical repair is an option in severe cases. The sutureless technique, which avoids direct suture of vessel walls, was initially described for congenital pulmonary vein stenosis and has been widely performed due to its good restenosis-free rate. CASE PRESENTATION: A 52-year-old male developed left pulmonary vein occlusion after catheter ablation for atrial fibrillation. The surgical repair with sutureless technique using the left atrial appendage was performed without any complications. Postoperative computed tomography demonstrated the revascularization of the pulmonary vein. CONCLUSIONS: The sutureless technique using the left atrial appendage is significantly reasonable particularly in case of left pulmonary vein stenosis or occlusion after catheter ablation for atrial fibrillation since it reduces the risks of restenosis and thromboembolism.

    DOI: 10.1186/s40792-020-00930-w

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  • Aorto-Right Atrial Fistula after Minimally Invasive Tricuspid Valve Repair: A Report of Two Cases. International journal

    Kouhei Ishidou, Aina Hirofuji, Naohiro Wakabayashi, Hiroyuki Kamiya

    The Thoracic and cardiovascular surgeon reports   9 ( 1 )   e55-e57   2020.1

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    We experienced two cases of postoperative iatrogenic aorto-right atrial fistula (ARAF) after tricuspid valve repair (TVR) using minimally invasive cardiac surgery (MICS) technique. In both the cases, the flow of ARAF passed through the sinus of Valsalva near the noncoronary cusp (NCC)/right coronary cusp (RCC) commissure or NCC to right atrium. The quality of the fine needle used in the MICS technique may be inferior to that used in conventional surgery; ARAF after TVR could be a unique pitfall with the MICS technique.

    DOI: 10.1055/s-0040-1718552

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  • The Cause of Massive Hemoptysis After Thoracic Endovascular Aortic Repair May Not Always Be an Aortobronchial Fistula: Report of a Case. International journal

    Natsuya Ishikawa, Aina Hirofuji, Naohiro Wakabayashi, Sentaro Nakanishi, Hiroyuki Kamiya

    Clinical medicine insights. Case reports   13   1179547620939078 - 1179547620939078   2020

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    Hemoptysis after thoracic endovascular/open aortic repair is relatively rare but a well-known complication, and normally diagnosed with aortobronchial fistula (ABF). Here, we present a patient who suffered from recurrent massive hemoptyses even after multiple thoracic endovascular aortic repairs (TEVARs), where hemoptysis was ultimately controlled by pneumonectomy. In this case, the bleeding source was not the aorta but the lung parenchyma itself, indicating the importance of raising awareness that the cause of massive hemoptysis after TEVAR may not always be an ABF.

    DOI: 10.1177/1179547620939078

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  • Debranching TEVARにおける周術期脳梗塞予防のためのECMOサポート付き脳分離術(ECMO supprted brain isolation to prevent perioperative stroke during debranching TEVAR)

    若林 尚宏, 石堂 耕平, 広藤 愛菜, 高橋 一輝, 中西 仙太郎, 石川 成津矢, 紙谷 寛之

    日本血管外科学会雑誌   29 ( Suppl. )   SF9 - 6   2020

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  • Failed transcatheter pulmonary artery embolization in a patient suffering from massive hemoptysis after thoracic endovascular aortic repair. International journal

    Natsuya Ishikawa, Shinsuke Kikuchi, Kouhei Ishidou, Aina Hirofuji, Sentaro Nakanishi, Hayato Ise, Naohiro Wakabayashi, Hiroyuki Kamiya

    Clinical medicine insights. Case reports   12   1179547619896577 - 1179547619896577   2019

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    An emergency thoracic endovascular aortic repair (TEVAR) with zone 2 landing without revascularization of the left subclavian artery was performed due to the impending rupture of a distal arch aneurysm in an old patient presenting hemoptysis. Two months later, the patient had recurrent massive hemoptyses and continued after additional zone 0 TEVAR. The lung parenchyma was considered to be the bleeding source and transcatheter pulmonary artery embolization was performed, and the episodes of massive hemoptysis appeared to have ceased. However, the patient died of sudden recurrent massive hemoptysis 40 days later. Inflammation and/or infection of the lung parenchyma adjunct to the aortic aneurysm could be cause of fatal hemoptysis, and aggressive therapy such as lung resection should be considered in such patients.

    DOI: 10.1177/1179547619896577

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MISC

Presentations

  • 心筋再生治療を目指して:Mycによる心筋細胞分裂誘導と心筋梗塞後の心機能保護

    広藤愛菜, 小山恭平, 田中宏樹, 宮谷和樹, 伊佐秀貴, 瀬戸川友紀, 鈴木文隆, 大久保諒, 潮田亮平, 國岡信吾, 筒井真博, 石川成津矢, 紙谷寛之

    第54回日本心臓血管外科学会学術 

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    Event date: 2024.2

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • Myc Induces Cardiomyocyte Mitosis in Adult Mice International conference

    Keystone Symposia, Heart Failure: All Cells Considered 

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    Event date: 2023.6

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  • Trim28 knockout accelerates isoproterenol-induced heart mass increase International conference

    Keystone Symposia, Heart Failure: All Cells Considered 

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    Event date: 2023.6

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  • H3K9me3の脱メチル化によるトランスポゾンの活性化は心筋細胞の遺伝子発現に影響を与える

    辻田 悠希, 小山 恭平, 広藤 愛菜, 潮田 亮平, 紙谷 寛之

    第45回日本分子生物学会年会 

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    Event date: 2022.11 - 2022.12

    Language:Japanese   Presentation type:Poster presentation  

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  • 心筋細胞の細胞周期に対するMycの特性評価

    広藤 愛菜, 小山 恭平, 河村 あさみ, 田中 彩乃, 辻田 悠希, 潮田 亮平, 神田 恵, 紙谷 寛之

    第45回日本分子生物学会年会 

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    Event date: 2022.11 - 2022.12

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  • 急性心筋梗塞後のoozing rupture,乳頭筋断裂による僧帽弁閉鎖不全症および左室瘤に対してstaged therapyを行った1例

    福田 はな, 広藤 愛菜, 望月 伸浩, 瀬戸川友紀, 鈴木 文隆, 成田 昌彦, 國岡 信吾, 筒井 真博, 白坂 知識, 石川成津矢, 紙谷 寛之

    第111回北海道外科学会 

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    Event date: 2022.9

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  • 心室細動を契機に診断された右冠動脈起始異常症に対して冠動脈バイパス術を施行した1例

    清水 要, 広藤 愛菜, 望月 伸浩, 瀬戸川友紀, 鈴木 文隆, 成田 昌彦, 國岡 信吾, 筒井 真博, 白坂 知識, 石川成津矢, 紙谷 寛之

    第122回日本臨床外科学会北海道支部例会 

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    Event date: 2022.9

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  • 重複大動脈弓と心室中隔欠損症に対して二期的に手術治療を行った1例

    橋本 侑樹, 広藤 愛菜, 望月 伸浩, 鈴木 文隆, 瀬戸川友紀, 成田 昌彦, 國岡 信吾, 筒井 真博, 白坂 知識, 石川成津矢, 紙谷 寛之

    第111回北海道外科学会 

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    Event date: 2022.9

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  • 狭心症発症を契機に診断された冠動脈肺動脈瘻より発生する3cm大の冠動脈瘤に対する1手術例

    丸岡 純, 広藤 愛菜, 望月 伸浩, 瀬戸川友紀, 鈴木 文隆, 成田 昌彦, 國岡 信吾, 筒井 真博, 白坂 知識, 紙谷 寛之

    第122回日本臨床外科学会北海道支部例会 

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    Event date: 2022.9

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  • 巨大冠動脈瘤と冠動脈肺動脈瘻を合併した1手術例

    広藤愛菜, 古堅あずさ, 鎌田武, 山崎健二, 道井洋吏

    第4回北海道外科関連学会機構合同学術集会 

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    Event date: 2021.9

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  • 生体弁による僧帽弁置換術後1年以内に人工弁機能不全を来し,僧帽弁再置換術を要した1例

    広藤愛菜, 古堅あずさ, 鎌田武, 山崎健二, 道井洋吏

    第125回日本循環器学会北海道地方会 

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    Event date: 2021.6

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Awards

  • 第54回日本心臓血管外科学会学術総会 優秀賞(基礎研究領域)

    2024.2   特定非営利活動法人日本心臓血管外科学会  

    広藤愛菜, 小山恭平, 田中宏樹, 宮谷和樹, 伊佐秀貴, 瀬戸川友紀, 鈴木文隆, 大久保諒, 潮田亮平, 國岡信吾, 筒井真博, 石川成津矢, 紙谷寛之

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    Award type:International academic award (Japan or overseas)  Country:Japan

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  • 第54回日本心臓血管外科学会学術総会 最優秀賞

    2024.2   特定非営利活動法人日本心臓血管外科学会  

    広藤愛菜, 小山恭平, 田中宏樹, 宮谷和樹, 伊佐秀貴, 瀬戸川友紀, 鈴木文隆, 大久保諒, 潮田亮平, 國岡信吾, 筒井真博, 石川成津矢, 紙谷寛之

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    Award type:International academic award (Japan or overseas)  Country:Japan

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