担当区分：筆頭著者   掲載種別：研究論文（国際会議プロシーディングス）  

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担当区分：責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1038/s41598-024-68508-2

PubMed

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出版者・発行元：Elsevier BV  

DOI： 10.2139/ssrn.4839151

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1177/03913988231184026

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担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1177/03913988231184027

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記述言語：日本語   出版者・発行元：北海道外科学会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1007/s10047-022-01330-7

PubMed

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担当区分：責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1111/aor.14443

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1111/aor.14380

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掲載種別：研究論文（学術雑誌）  

To develop a power generation system as a solution to the power supply problems of small active implantable medical devices, we proposed a new method to examine muscles using skeletal muscle contraction through electrical stimulation. Realization of the system requires data on the contraction characteristics of a part of the muscles through which blood flows; thus, a dedicated setup was built and verified using a goat. The connecting parts were attached to two points in the large muscle of the goat's trunk; one was fixed and the other slid along the guide. The distance and force between the two points, approaching each other, were measured by contracting the muscle between the points using electrical stimulation and pulling the measurement cart. The contraction distance and force were measured simultaneously, and the dynamic work of the contraction was calculated. The muscle work occurred with almost the same time delay regardless of the load, and the work tended to be greater when the contraction force, and not the contraction distance, of the muscle was large. The setup is physiological, simple, and versatile. Our setup can potentially be used in the development of implantable power generation systems and in other related fields.

DOI： 10.1142/S0219519422500075

Scopus

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

Objective: There is a need for small diameter vascular substitutes in the absence of available autologous material. A small diameter, long tissue engineered vascular graft was developed using a completely autologous approach called "in body tissue architecture technology (iBTA)". The aim of this pilot study was to evaluate "Biotubes", iBTA induced autologous collagenous tubes, for their potential use as small diameter vascular bypass conduits. Methods: Biotubes (internal diameter 4 mm, length 50 cm, wall thickness 0.85 mm) were prepared by subcutaneous embedding of plastic moulds (Biotube Maker) in three goats for approximately two months. Allogenic Biotubes (length 10 cm [n = 2], 15 cm [n = 2], 22 cm [n = 2]) were bypassed to both carotid arteries by end to side anastomosis with their ligation between the anastomoses in another three goats. Residual Biotubes were examined for their mechanical properties. After four weeks, the harvested Biotubes were evaluated histologically. Results: All Biotubes had sufficient pressure resistance, approximately 3000 mmHg. Although wall thickening occurred at two proximal anastomosis sites, all six grafts were patent without luminal thrombus formation, stenosis, or aneurysm deformation throughout the implantation period. Endothelial cells covered both anastomosis sites almost completely, with partial covering in the central portion of the grafts. Furthermore, α smooth muscle actin positive cells infiltrated the middle layer along almost the entire graft length. Conclusion: This preliminary study showed that small diameter, long, tissue engineered Biotubes could function properly as arterial bypass conduits in a large animal for one month without any abnormal change in vascular shape. Thus, small diameter, long Biotubes are potentially viable conduits, which are biocompatible and labour non-intensive, and therefore, suitable for clinical practice. Additionally, Biotubes can start the regeneration process in a short period of time.

DOI： 10.1016/j.ejvsvf.2022.01.004

PubMed

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記述言語：英語   掲載種別：研究論文（国際会議プロシーディングス）  

DOI： 10.1109/EMBC46164.2021.9629561

PubMed

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担当区分：筆頭著者   記述言語：日本語   掲載種別：研究論文（学術雑誌）  

DOI： https://doi.org/10.11239/jsmbe.Annual59.330

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

DOI： 10.11239/jsmbe.Annual59.579

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記述言語：日本語   掲載種別：研究論文（学術雑誌）  

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担当区分：筆頭著者   記述言語：日本語   掲載種別：研究論文（その他学術会議資料等）  

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担当区分：責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1299/jsmedmc.2021.542

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担当区分：筆頭著者   記述言語：日本語   掲載種別：研究論文（その他学術会議資料等）  

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

Extracorporeal membrane oxygenation (ECMO) plays an important role in the coronavirus disease 2019 (COVID-19) pandemic. Management of thrombi in ECMO is generally an important issue; especially in ECMO for COVID-19 patients who are prone to thrombus formation, the thrombus formation in oxygenators is an unresolved issue, and it is very difficult to deal with. To prevent thromboembolic complications, it is necessary to develop a method for early thrombus detection. We developed a novel method for detailed real-time observation of thrombi formed in oxygenators using indocyanine green (ICG) fluorescence imaging. The purpose of this study was to verify the efficacy of this novel method through animal experiments. The experiments were performed three times using three pigs equipped with veno-arterial ECMO comprising a centrifugal pump (CAPIOX SL) and an oxygenator (QUADROX). To create thrombogenic conditions, the pump flow rate was set at 1 L/min without anticoagulation. The diluted ICG (0.025 mg/mL) was intravenously administered at a dose of 10 mL once an hour. A single dose of ICG was 0.25mg. The oxygenator was observed with both an optical detector (PDE-neo) and the naked eye every hour after measurement initiation for a total of 8 hours. With this dose of ICG, we could observe it by fluorescence imaging for about 15 minutes. Under ICG imaging, the inside of the oxygenator was observed as a white area. A black dot suspected to be the thrombus appeared 6-8 hours after measurement initiation. The thrombus and the black dot on ICG imaging were finely matched in terms of morphology. Thus, we succeeded in real-time thrombus detection in an oxygenator using ICG imaging. The combined use of ICG imaging and conventional routine screening tests could compensate for each other's weaknesses and significantly improve the safety of ECMO.

DOI： 10.1111/aor.13999

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記述言語：日本語   掲載種別：研究論文（学術雑誌）  

CiNii Books

CiNii Research

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その他リンク： https://search.jamas.or.jp/link/ui/2021277489

記述言語：英語   掲載種別：研究論文（学術雑誌）  

In roller pumps used for cardiopulmonary bypass (CPB), the degree of blockage within the tube resulting from compression of the tube by the rollers, or the degree of occlusion, is closely related to hemolysis, with both tight occlusive and non-occlusive degrees promoting hemolysis. There are as yet no international standards regarding methods of adjusting occlusiveness, and the amount of mechanical stress exerted upon blood remains unknown. To prevent hemolysis during CPB using roller pumps, there is a need to clarify and quantitatively assess the mechanical stress of the occlusiveness of the roller pump. In this study, we have developed a degree of occlusion quantification system which constructs the flow channel shape within an occluded tube from red optical density images, and we have verified the validity of this system. Utilizing a linear actuator, an acrylic roller and raceway, a solution colored with simulated blood powder, and a 3/8-inch vinyl chloride tube, this system uses a camera to capture red optical density images within an occluded tube and constructs the tube flow channel shape using a formula manipulation system. To verify the accuracy of this system, we compared the thickness of a cross-section of the flow channel constructed with the degree of occlusion quantification system with the thickness of a cross-section of silicone cured under the same occlusion conditions. Our experiments indicated that for areas with a small tube gap, this system can construct highly accurate three-dimensional shapes and obtain quantitative indicators assessing the degree of occlusion.

DOI： 10.1007/s10047-020-01211-x

PubMed

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

Chronic blood trauma caused by the shear stresses generated by mechanical circulatory support (MCS) systems is one of the major concerns to be considered during the development of ventricular assist devices. Large multimers with high-molecular-weight von Willebrand factor (VWF) are extended by the fluid forces in a shear flow and are cleaved by ADAMTS13. Since the mechanical revolving motions in artificial MCSs induce cleavage in large VWF multimers, nonsurgical bleeding associated with the MCS is likely to occur after mechanical hemodynamic support. In this study, the shear stress (~ 600 Pa) and exposure time related to hemolysis and VWF degradation were investigated using a newly designed mechanical shuttle shear flow tester. The device consisted of a pair of cylinders facing the test section of a small-sized pipe; both the cylinders were connected to composite mechanical heads with a sliding-sleeve structure for axial separation during the withdrawing motion. The influence of exposure time, in terms of the number of stress cycles, on hemolysis and VWF degradation was confirmed using fresh goat blood, and the differences in the rates of dissipation of the multimers were established. The plasma-free hemoglobin levels showed a logarithmic increase corresponding to the number of cycles, and the dissipation of large VWF multimers occurred within a few seconds under high shear stress flow conditions.

DOI： 10.1007/s10047-020-01219-3

PubMed

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出版者・発行元：Springer International Publishing  

DOI： 10.1007/978-3-030-66169-4_11

CiNii Research

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その他リンク： https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K18021/

掲載種別：研究論文（学術雑誌）   出版者・発行元：Japanese Society for Medical and Biological Engineering  

DOI： 10.14326/abe.10.113

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

In this study, we developed a trans-valve left ventricular assist device (LVAD) that unites a rear-impeller axial-flow blood pump (AFBP) and a polymer membrane valve placed at the aortic valve position. The diameter and length of the rear impeller AFBP was 12 and 63 mm, respectively. The polymer membrane valve was similar to the jelly-fish valve consisting of a valve leaflet made of silicone rubber (thickness 0.5 mm), valve ring (diameter: 25 mm), and valve spokes. The trans-valve LVAD was examined in a mock circulation. An implantable pulsatile flow (PF) VAD was connected to an atrial reservoir to simulate the left ventricle (LV), and the Hall valve was worn in the inflow port, and the trans-valve LVAD was placed in the outflow port as an outflow valve. When the motor rotational speed increased to 26 400 rpm, the mean aortic flow increased from 4.2 to 5.3 L/min, mean aortic pressure increased from 83.4 to 100 mm Hg, and mean motor current of the implantable PF VAD decreased from 1.18 to 0.94 A (unloading effect on LV -21%). The energy equivalent pressure increased from 85.2 to 102 mm Hg, and surplus hemodynamic energy (SHE) decreased by -15.4% from the baseline. In conclusion, the trans-valve LVAD has an advantage of preserving pulsatility without any complicated mechanism and is a novel and promising LV support device.

DOI： 10.1111/aor.13687

PubMed

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

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記述言語：英語   掲載種別：研究論文（国際会議プロシーディングス）   出版者・発行元：Institute of Electrical and Electronics Engineers Inc.  

Rotary blood pump (RP) is one of the most important devices in the treatment of profound heart failure and is known to reduce the pulse in the blood pressure waveform, especially when it is used for axial flow. In an outpatient clinic, checking the pulse of a patient implanted with an RP can help diagnose the patient's condition. For that purpose, animal experiments with healthy adult goats implanted with the EVAHEART system were carried out after obtaining ethical committee approval. Visual imaging of the goats' faces was recorded using a video camera. The pulse waves were clearly recorded using the newly developed pulse diagnosis system with video imaging and compared with laser Doppler flowmeter and time series data. Spectral analysis of the time series data showed the usefulness of video imaging from outside the body. Clinical applications are planned, and this newly developed method is expected to be a useful diagnostic method for evaluating the cardiac function in patients implanted with RPs in the future.

DOI： 10.1109/EMBC44109.2020.9175425

Scopus

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記述言語：英語   掲載種別：研究論文（国際会議プロシーディングス）   出版者・発行元：Institute of Electrical and Electronics Engineers Inc.  

With the progress of surgical technology, the survival rate after resection of esophageal and tongue carcinomas has improved. However, the surgical protocol for esophageal and tongue surgery is complex, and surgery for elderly esophageal and tongue carcinoma patients with cardiopulmonary dysfunction is difficult. Using an artificial tongue and esophagus will be helpful for patients. However, peristalsis of foods depends on food size, taste, and viscosity. This study developed and evaluated a new diagnosis machine for drinking and peristalsis motion. Before clinical evaluation, animal experiments were performed on healthy adult goats using a stereo camera. After a feasibility study of the diagnosis system for peristalsis, clinical evaluation was conducted on healthy normal volunteers. We observed no aspiration pneumonia. The foods and drinks tested were safe. There was no mis-swallowing, but the participants' feeling with regard to taste differed. Overall, the results indicated that the quantitative swallowing and peristalsis diagnosis system is safe. Evaluation of the visual imaging and spectral analysis gave us useful information about peristalsis, which will help us design an artificial tongue and esophagus with a good control mechanism in the near future.

DOI： 10.1109/EMBC44109.2020.9176039

Scopus

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

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担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：公益社団法人 日本生体医工学会  

We previously reported the development of a new hybrid medical material comprising bio-based materials with high biocompatibility and artificial materials with characteristics of excellent strength and processability. This material shows sufficient biocompatibility and excellent stability in vivo. Moreover, when applied to the surface of an implantable sensor, the biological reaction on the sensor function surface can be well controlled. For commercialization and widespread use of hybrid materials with such superior properties, sterilization and storage are critical considerations, given that hybrid materials must be processed outside the body prior to application as medical materials in vivo, thus posing a risk of contamination despite best efforts. Therefore, the aim of the present study was to establish an optimal sterilization method that will not impair the biocompatibility of the hybrid material. Toward this end, we tested six sterilization methods for the hybrid material: autoclave (121℃, 20 min), dry heat (160℃, 120 min), ethylene oxide gas (37℃, 120 min), hydrogen peroxide plasma (45℃, 45 min), and gamma ray (25 kGy) with and without lyophilization. After sterilization, the material was cultured with vascular endothelial cells to evaluate the engraftment rate, and was observed with light and scanning electron microscopy to determine shape and structure changes. The results demonstrated that gamma sterilization without lyophilization was the best sterilization method for this material, which preserved the collagen network and showed no change in number of adhered vascular endothelial cells compared to the pre-sterilized material. These findings are useful to promote the commercialization of this hybrid material with combined advantages of synthetic and bio-based materials for widespread clinical application in the engineering of artificial organs.

DOI： 10.14326/abe.9.83

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記述言語：日本語   出版者・発行元：公益社団法人 日本生体医工学会  

<p>医療生体情報は安静状態か拘束された制約下での計測が必須の条件となっているが、計測時の環境が与える計測結果への悪影響は不可避なものとして黙認されている。非接触センサの開発も行われているが、感度や精度が低いことに加え、特定の範囲内でのみ計測が可能になるなど、包括的な解決にならない事が課題である。これまでの研究により装着感の小さい接触型センサの開発を進めてきた。これらの装着感の少ないセンサをひとつのデバイスとして統合し、これまで同時に計測することができなかった生体情報（脈拍・心電図・体温分布・体動）をひとつの衣服から得ることが可能となるスマートテキスタイルの開発を行う。スマートテキスタイルは既存のウェアラブルデバイスが持つ制約から解放する外乱のない計測結果を得られるだけでなく、これまで安定計測できなかった睡眠・食事・運動時などあらゆる場面で生体情報を取得することを可能とするものである。装着感を評価する方法で一般的な手法は、主観的な評価が主であり一般性と定量性が欠けていることが課題である。そこで、デバイスが生体に与えるストレスを循環生理学的に定量的に評価することで、装着感のない新しいセンサ開発を行う。本研究により作製したスマートテキスタイルを用いることで、全生活時間のビッグデータを取得しこの情報を元に新たな医療機器・ヘルスケアデバイスを開発することが最終的な目標である。</p>

DOI： 10.11239/jsmbe.Annual58.409

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記述言語：日本語   出版者・発行元：公益社団法人 日本生体医工学会  

<p>人工心肺用ローラポンプ使用時における溶血リスク軽減のために、ローラポンプ圧閉度の定量評価が求められている。我々は、機械的ストレス算出に必要となるチューブ内の流路形状を赤色濃淡画像から可視化するシステムを開発した。このシステムは、リニアアクチュエータ、アクリルで作製したローラとレースウェイ、模擬血液粉末で着色した溶液、3/8 インチの塩化ビニルチューブを用い、圧閉されたチューブ内赤色濃淡画像をカメラで撮影し、数式処理システムにて流路形状を構築するシステムである。本研究では、圧閉度可視化システムの精度を評価するために、赤色濃淡画像から計測された流路断面の厚みと、同じ圧閉条件下にて硬化させた高精細転写用シリコーン断面の厚みを比較した。なお、硬化させたシリコーンは3次元形状測定機にて測定した。実験の結果より、可視化システムで計測された流路断面の厚みとシリコーンの厚みを比較すると、流路断面形状がよく近似でき、線形関係が得られた厚み領域で示されることがわかった。ただし、流路断面の厚みが120 μｍ以上の場合、赤色濃淡画像から推定された流路断面形状はシリコーン転写3次元形状と比べて低値を示した。これらのことから、本システムでは圧閉されたチューブ内の狭小流路については高精度の3次元形状を構築できると考えられた。</p>

DOI： 10.11239/jsmbe.Annual58.266

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

In this study, rear-impeller axial flow blood pumps (RIAFBP) were developed to realize a trans-valve axial ventricular assist device (VAD) which consists of the latter blood pump and a polymer monomembrane aortic valve, such as the jellyfish valve. The motor of the RIAFBP is installed in the left ventricle, and its impeller is placed at the aortic valve position. In the prototype RIAFBP, the rotation of the motor is sustained by polyethylene bushings. The RIAFBP has a length of 50 mm and diameter of 19.6 mm. The miniature RIAFBP has the same construction as that of the prototype; however, it employs a ceramic bearing and fin bearing to improve endurance and to reduce blood stagnation. The miniature RIAFBP has a length of 63 mm and diameter of 12 mm. Both RIAFBPs were examined by an in vitro experiment using a 33% glycerin solution. The prototype RIAFBP achieved a maximum pump outflow of 8.5 L/min against a pump head of 100 mm Hg at a rotational speed of 12 000 rpm. The miniature RIAFBP achieved 7 L/min against a pump head of 70 mm Hg at a rotational speed of 21 600 rpm. In conclusion, the miniature RIAFBP has enough pump performance to realize the trans-valve axial VAD.

DOI： 10.1111/aor.13476

PubMed

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記述言語：英語   掲載種別：研究論文（国際会議プロシーディングス）   出版者・発行元：Institute of Electrical and Electronics Engineers Inc.  

Your heart rate and blood pressure are respond to the curve, slope, lane width, and road surface friction coefficient of the expressway design. However, no report was reported concerning about the Expressway design from the viewpoint of medical information of the driver until now. To prevent the traffic accident, human factor is of course one of the most important factors. In this study, the Cloud Database Construction for the Expressway Design by the use of the Medical Information had been tried to carry out. HR response and PWV responses had been tried to be analyzed by the sensors in the car during driving. LF, HF and LF/HF of Heart rate variability had been calculated and tagged with expressway information including left and right curve, slope, lane width, and road surface friction coefficient. Furthermore, pulse of the descending aorta had been tried to be recorded from the sensor in a driver seat, so, the pulse wave velocity and blood pressure could be evaluated. Recording system of an Eye movement, pupil diameter, cerebral blood flow, and EEG are now under construction. So, all human driver's data will be combined in the Cloud of the Central office. this method will be useful for the development of the designing method the Expressway in near future.

DOI： 10.1109/EMBC.2019.8856546

Scopus

PubMed

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記述言語：日本語   出版者・発行元：公益社団法人 日本生体医工学会  

<p>医療生体情報は安静状態か拘束された制約下での計測が必須であり、計測時の環境が与える計測結果への影響は必要悪として無視されている。我々は装着感のない接触型センサを開発しており、計測による制約から解放することで外乱のない計測結果を得られるだけでなく、これまで安定計測できなかった睡眠・食事・運動時などあらゆる場面で生体情報を取得することを目的するものである。開発したシステムと既存のセンサとで生体に与えるストレス影響を循環生理学的に比較してその装着感を定量的に評価する。本研究により全生活時間のビッグデータを取得し、この情報を元に新たな医療機器・ヘルスケアデバイスを開発することが最終目標である。本発表では、3つの拠点で実施した、筋電・心電・温度・心拍を対象としたセンサの開発と装着感の評価に関する報告を行う。</p>

DOI： 10.11239/jsmbe.Annual57.S36_2

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記述言語：日本語   出版者・発行元：公益社団法人 日本生体医工学会  

生体医工学治療が支える少子高齢社会においては、重篤な疾患治療に対する医療機器開発応用を迅速に進めるとともに、安全性有効性に関する科学的根拠に基づく評価を非臨床で進める必要がある。東北大学加齢医学研究所非臨床試験推進センターでは、全国共同利用共同研究施設として植込み型補助人工心臓を例として長期動物実験をはじめ、生体医工学に関連する基盤技術を応用して生体適合性および血行力学的有効性の評価を行ってきている。ヒト臨床試験に先立って行われる非臨床動物試験評価では、ヒトまたは患者機能の代替とおいて動物試験が行われるが、種別による差の他にも個体差や環境要因、個々の計測誤差要因を含む収集データ精度を補償することが極めて重要である。本報告では、植込み型人工臓器と補助循環治療を例として血行動態評価に関する非臨床医工学モデリング手法と、モデリングにおけるエンティティへの種種アプローチ手法によるモダリティ評価について提示する。またあわせて一貫したデータ管理アクセスの試みについて紹介する。

DOI： 10.11239/jsmbe.annual57.s220_1

CiNii Research

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記述言語：日本語   出版者・発行元：公益社団法人 日本生体医工学会  

<p>【背景】解離性大動脈瘤では解離偽腔内に流入する血流がもたらす乱流による複雑な圧流量特性が観察される。治療効果と安全性を評価する上では血管内治療用の解離性大動脈瘤内の血圧血流速の医工学的モデリングが重要となっている。【目的】これまで解離性大動脈瘤の動物実験モデルを作成し血行動態の再現を行ってきた。本研究では動物実験から得られた超音波画像を基に解離性大動脈瘤血行動態のモデリングを目的としてそれらの解析手法に関して評価を進めた。【方法】〔動物解離モデル〕健常成山羊を麻酔下にて開胸し、下行大動脈の中枢側外膜を切開後、中膜を外科的に剥離し、血管開口部を切開し大動脈解離を作成した。〔モデル化手法・解析〕下行大動脈の超音波短軸像を血管長軸に沿って1mm毎の断層像とし、データの数値的再構成により形状モデルを構築した。作成したモデルを用いて模擬循環回路による流れ可視化と数値流体解析を行った。【まとめ】動物モデルでは臨床に近い形態と血流を再現できる一方、血管内治療の血行力学的評価については血流形態の差や計測誤差の課題がある。解離性大動脈瘤治療ではさまざまな医工学モデリング方法論で安全性評価が可能である。</p>

DOI： 10.11239/jsmbe.Annual57.S220_2

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掲載種別：研究論文（学術雑誌）   出版者・発行元：Japan Society of Mechanical Engineers  

DOI： 10.1299/jsmebio.2019.32.1e24

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記述言語：日本語   出版者・発行元：一般社団法人 人工知能学会  

東北地方も新潟も圧倒的な医療崩壊の波に襲われている。地域医療では病院は、もはや潰れるほうが当たり前、存続できる方が珍しいと言われる現在、人工知能に寄せられる期待は大きい。圧倒的に不足しているのは、医師・看護師・介護者などのマンパワーであり、ここに人工知能が介在すれば改善の余地はある。しかし患者側の心に、気持ちに寄り添わない医療・介護に存在の意味はない。現在の人工知能・会話ボットは、ある方向では、チューリングテストをクリアできるほど発展を認めているが、患者さんの気持ちが読めるわけではない。そこで人体表面の映像より多チャンネル皮下血流を計測し、周波数解析や非線形数学理論の信号処理により自律神経機能バランスを定量診断し高次機能を逆問題で推定する「高齢者の気持ちがわかる」アルゴリズムを開発した。人工知能、人間との会話実験を行い、対象の血流変動を定量診断すると、現存の対話人工知能では、特にタイプAのような対象では、人間相手の会話と人工知能相手の会話では自律神経トーヌスの変動が観測されている。このようなシステムは次世代の高齢者の「気持ちがわかる」ためのインターフェースとして将来性が注目される

DOI： 10.11517/pjsai.jsai2019.0_2n5j1302

CiNii Research

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Nature Publishing Group  

The newly developed radioisotope-free technique based on magnetic nanoparticle detection using a magnetic probe is a promising method for sentinel lymph node biopsy. In this study, a novel handheld magnetic probe with a permanent magnet and magnetic sensor is developed to detect the sentinel lymph nodes in breast cancer patients. An outstanding feature of the probe is the precise positioning of the sensor at the magnetic null point of the magnet, leading to highly sensitive measurements unaffected by the strong ambient magnetic fields of the magnet. Numerical and experimental results show that the longitudinal detection length is approximately 10 mm, for 140 μg of iron. Clinical tests were performed, for the first time, using magnetic and blue dye tracers-without radioisotopes-in breast cancer patients to demonstrate the performance of the probe. The nodes were identified through transcutaneous and ex-vivo measurements, and the iron accumulation in the nodes was quantitatively revealed. These results show that the handheld magnetic probe is useful in sentinel lymph node biopsy and that magnetic techniques are widely being accepted as future standard methods in medical institutions lacking nuclear medicine facilities.

DOI： 10.1038/s41598-018-19480-1

Scopus

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

© 2018 The Authors. High-precision monitoring of electrophysiological signals with high spatial and temporal resolutions is one of the most important subjects for elucidating physiology functions. Recently, ultraflexible multielectrode arrays (MEAs) have been fabricated to establish conformal contacts with the surface of organs and to measure propagation of electrophysiological signals with high spatial-temporal resolution; however, plastic substrates have high Young's modulus, causing difficulties in creating appropriate stretchability and blood compatibility for applying them on the dynamically moving and surgical bleeding surface of the heart. Here, we have successfully fabricated an active MEA that simultaneously achieves nonthrombogenicity, stretchability, and stability, which allows long-term electrocardiographic (ECG) monitoring of the dynamically moving hearts of rats even with capillary bleeding. Because of the active data readout, the measured ECG signals exhibit a high signal-to-noise ratio of 52 dB. The novel stretchable MEA is carefully designed using state-of-the-art engineering techniques by combining extraordinarily high gain organic electrochemical transistors processed on microgrid substrates and a coating of poly(3-methoxypropyl acrylate), which exhibits significant antithrombotic properties while maintaining excellent ionic conductivity.

DOI： 10.1126/sciadv.aau2426

Scopus

PubMed

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担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（国際会議プロシーディングス）  

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担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（国際会議プロシーディングス）  

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記述言語：日本語   掲載種別：研究論文（学術雑誌）  

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記述言語：日本語   掲載種別：研究論文（その他学術会議資料等）  

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記述言語：日本語  

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記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：(一社)日本人工臓器学会  

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記述言語：日本語  

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：NATURE PUBLISHING GROUP  

Compromised circulation is a potential complication during the postoperative period following tissue transplantation. The use of a monitoring device allows physicians to detect compromised circulation immediately. Such monitoring devices need to be continuously usable, wearable, and area-detectable. However, existing devices fail to satisfy all of these requirements simultaneously. We developed a wearable, multipoint pulse wave-monitoring device. An array of reflective optical sensors implemented on a thin film substrate was used as a lightweight and flexible probe. As a model of tissue transplantation, an inguinal flap in a Wistar rat was dissected and freed from all subcutaneous tissue. By ligating the artery or vein, ischemia or congestion was induced in the tissue. In a human study, ischemia or congestion was induced in the palm by pressing the feeding artery or cutaneous vein, respectively. The amplitude of the pulse wave was evaluated using the power spectrum of Fourier transformed signals. Pulse wave amplitude significantly decreased under compromised circulation in both animal and human models. Moreover, we accomplished 1 week of continuous wireless monitoring in healthy subjects. These results demonstrated the potential utility of the developed device in postoperative blood-flow monitoring to improve the rescue rate of transplanted tissue.

DOI： 10.1038/s41598-017-10115-5

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：SPRINGER  

There are recent reports of hybrid tissue-fabric materials with good performance-high biocompatibility and high mechanical strength. In this study, we demonstrate the capability of a hybrid material as a long-term filter for blood proteins. Polyester fabrics were implanted into rats to fabricate hybrid tissue-fabric material sheets. The hybrid materials comprised biological tissue grown on the fabric. The materials were extracted from the rat's body, approximately 100 days post-implantation. The tissues were decellularized to prevent immunological rejection. An antithrombogenicity test was performed by dropping blood onto the hybrid material surface. The hybrid material showed lesser blood coagulation than polysulfone and cellulose. Blood plasma was filtered using the hybrid material to evaluate the protein removal percentage and the lifetime of the hybrid material in vitro. The hybrid material showed a comparable performance to conventional filters for protein removal. Moreover, the hybrid material could work as a protein filter for 1 month, which is six times the lifetime of polysulfone.

DOI： 10.1007/s10439-016-1781-5

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記述言語：日本語   出版者・発行元：[科学情報出版]  

CiNii Books

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記述言語：日本語  

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記述言語：日本語  

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記述言語：日本語  

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記述言語：日本語  

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：WILEY-BLACKWELL  

Histopathological analysis can provide important information in long-term experiments with total artificial heart (TAH). Recently, a new type of blood pump, the helical flow total artificial heart (HF-TAH) was developed. This study aimed to investigate the changes in selected vital organs in animal experiments with implanted HF-TAH. Samples from lung, liver, and kidneys from two female goats (No. 1301 and No. 1304) with implanted HF-TAH were analyzed. Tissue samples were fixed in 10% formaldehyde and 4 mm thick transverse sections were stained with hematoxylin-eosin (HE). Additional staining was done for detection of connective tissue (Masson-Goldner stain) and for detection of iron (hemosiderin) deposits (Perls stain). Sections were scanned at 1003 and 5003 magnification with a light microscope. Experiment no. 1301 survived 100 days (cause of termination was heavy damage of the right pump); experimental goat no. 1304 survived 68 days and was sacrificed due to severe right hydrodynamic bearing malfunction. Histopathological analysis of liver samples proved signs of chronic venostasis with limited focal necrotic zones. Dilated tubules, proteinaceous material in tubular lumen, and hemosiderin deposits were detected in kidney samples. Contamination of the organs by embolized micro-particles was suspected at the autopsy after discovery of visible damage (scratches) of the pump impeller surface (made from titanium alloy) in both experiments. Sporadic deposits of foreign micro-particles (presumably titanium) were observed in most of the analyzed parenchymal organs. However, the described deposits were not in direct connection with inflammatory reactions in the analyzed tissues. Histopathological analysis showed the presence of minimal contamination of the lung, kidney, and liver tissue samples by foreign material (titanium very likely). The analysis showed only limited pathological changes, especially in liver and kidneys, which might be attributed to the influence of artificial perfusion often observed in chronic TAH experiments.

DOI： 10.1111/aor.12689

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記述言語：日本語   出版者・発行元：(一社)日本統合医療学会  

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記述言語：日本語   出版者・発行元：日本循環制御医学会  

DOI： 10.11312/ccm.37.185

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本統合医療学会  

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記述言語：日本語   出版者・発行元：(一社)日本統合医療学会  

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：NATURE PUBLISHING GROUP  

In vivo electronic monitoring systems are promising technology to obtain biosignals with high spatiotemporal resolution and sensitivity. Here we demonstrate the fabrication of a biocompatible highly conductive gel composite comprising multi-walled carbon nanotube-dispersed sheet with an aqueous hydrogel. This gel composite exhibits admittance of 100 mS cm(-2) and maintains high admittance even in a low-frequency range. On implantation into a living hypodermal tissue for 4 weeks, it showed a small foreign-body reaction compared with widely used metal electrodes. Capitalizing on the multi-functional gel composite, we fabricated an ultrathin and mechanically flexible organic active matrix amplifier on a 1.2-mu m-thick polyethylene-naphthalate film to amplify (amplification factor: B200) weak biosignals. The composite was integrated to the amplifier to realize a direct lead epicardial electrocardiography that is easily spread over an uneven heart tissue.

DOI： 10.1038/ncomms11425

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：WILEY-BLACKWELL  

Lymph nodes are selectively removed in order to diagnose cancer metastases. In this investigation, we developed a magnetic probe for intraoperatively detecting the accumulation of magnetic fluid. We built a magnetic probe consisting of a permanent magnet and a Hall effect sensor, and investigated its sensitivity. The results agreed well with the numerical results. In addition, a prototype probe detected 1.6 mL of magnetic fluid located 30 mm from the probe head.

DOI： 10.1002/ecj.11757

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記述言語：日本語  

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記述言語：日本語  

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記述言語：英語  

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記述言語：英語  

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記述言語：日本語  

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記述言語：英語  

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：NATL ACAD SCIENCES  

We report a fabrication method for flexible and printable thermal sensors based on composites of semicrystalline acrylate polymers and graphite with a high sensitivity of 20 mK and a high-speed response time of less than 100 ms. These devices exhibit large resistance changes near body temperature under physiological conditions with high repeatability (1,800 times). Device performance is largely unaffected by bending to radii below 700 mu m, which allows for conformal application to the surface of living tissue. The sensing temperature can be tuned between 25 degrees C and 50 degrees C, which covers all relevant physiological temperatures. Furthermore, we demonstrate flexible active-matrix thermal sensors which can resolve spatial temperature gradients over a large area. With this flexible ultrasensitive temperature sensor we succeeded in the in vivo measurement of cyclic temperatures changes of 0.1 degrees C in a rat lung during breathing, without interference from constant tissue motion. This result conclusively shows that the lung of a warm-blooded animal maintains surprising temperature stability despite the large difference between core temperature and inhaled air temperature.

DOI： 10.1073/pnas.1515650112

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

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記述言語：英語   出版者・発行元：(一社)日本人工臓器学会  

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

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記述言語：日本語   出版者・発行元：(一社)ライフサポート学会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：SPRINGER JAPAN KK  

The helical flow pump (HFP) was invented to be an ideal pump for developing the TAH and the helical flow TAH (HFTAH) using two HFPs has been developed. However, since the HFP is quite a new pump, hydrodynamic characteristics inside the pump are not clarified. To analyze hydrodynamic characteristics of the HFP, flow visualization study using the particle image velocimetry and computational fluid dynamics analysis were performed. The experimental and computational models were developed to simulate the left HFP of the HFTAH and distributions of flow velocity vectors, shear stress and pressure inside the pump were examined. In distribution of flow velocity vectors, the vortexes in the vane were observed, which indicated that the HFP has a novel and quite unique working principle in which centrifugal force rotates the fluid in the helical volutes and the fluid is transferred from the inlet to the outlet helical volutes according to the helical structure. In distribution of shear stress, the highest shear stress that was considered to be occurred by the shunt flow across the impeller was found around the entrance of the inlet helical volute. However, it was not so high to cause hemolysis. This shunt flow is thought to be improved by redesigning the inlet and outlet helical volutes. In distribution of pressure, negative pressure was found near the entrance of the inlet helical volute. However, it was not high. Negative pressure is thought to be reduced with an improvement in the design of the impeller or the vane shape.

DOI： 10.1007/s10047-015-0828-y

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：WILEY-BLACKWELL  

Severe cardiac failure patients require a total artificial heart (TAH) to save life. To realize a TAH that can fit a body of small stature and has high performance, high durability, good anatomical fitting, good blood compatibility, and physiological control, we have been developing the helical flow TAH (HFTAH) with two helical flow pumps with hydrodynamic levitation impeller. Animal experiments of the HFTAH were conducted to perform in vivo studies. The HFTAH was implanted in 13 adult female goats weighing 45.0-64.0kg. After surgery, neither anti-coagulant nor anti-platelet medication was given systemically. The HFTAH was usually driven with a quasi-pulsatile mode. The 1/R control or P control was applied to control the circulation. The P control is a new method using simplified equation of the 1/R control. The HFTAH could be implanted in all goats with good anatomical fitting. Two goats survived for a long time (100 and 68 days). Major causes of termination were device failure and surgical complications. In the device failure, trouble with hydrodynamic bearing was conspicuous. In the two long-term survived goats, experiments were terminated with bearing instability that was probably caused by the suction effect. In these goats, hemolysis occurred on postoperative day 88 and 44, which was considered to be relevant to the bearing trouble. Thrombus was found at the broken right bearing of the 100-day survived goat. However, antithrombogenicity of the pump is expected to be good unless bearing trouble occurs. In two long-term survived goats, the 1/R control or P control worked appropriately to prevent the elevation of right atrial pressure. In both goats, hemodynamic parameters changed with the condition of the animals, liver and kidney functions remained almost normal except when recovering from surgery and during hemolysis, and total protein recovered 2 weeks after surgery. Although instability of the hydrodynamic bearing should be improved, performance of the HFTAH with physiological control could be demonstrated.

DOI： 10.1111/aor.12543

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記述言語：日本語   出版者・発行元：一般社団法人 日本生体医工学会  

Hybrid material consisting of artificial scaffold and living tissue achieves both of high biocompatibility and mechanical strength. The purpose of this study was to investigate the feasibility of the hybrid material for use as a blood protein filter. Sheet-like hybrid materials were fabricated in animals, and their antithrombogenicity and filter performance were evaluated. The materials were extracted from the body at 100 days after implantation. The tissues were decellularized using sodium dodecyl sulfate for preventing immunological rejection. A short-term test of antithrombogenicity was carried out by dropping blood on the material. The quantity of blood coagulation on the hybrid material was much smaller than those of polysulfone and cellulose. A blood cannula made of the hybrid material was implanted in a goat to evaluate the long-term antithrombogenicity. No clot was observed on the cannula even after 1 month of continuous exposure to blood. Blood plasma was filtered through the hybrid material to evaluate the removal of protein and the lifetime. The hybrid material showed protein removal ratio comparable to the conventional filters. The lifetime of one month was 6 times as long as that of polysulfone

DOI： 10.11239/jsmbe.53.S194_03

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記述言語：英語  

DOI： 10.4172/2379-1764.1000145

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記述言語：英語   掲載種別：研究論文（国際会議プロシーディングス）   出版者・発行元：IEEE  

We developed a magnetic resonance imaging (MRI) -detectable wireless flexible pressure sensor with pressure-sensitive LC resonator fabricated on a flexible film substrate. Measuring pressures in the body such as blood vessels and cardiac ventricle are very important in making diagnoses and in postoperative observation. However, conventional wired pressure sensors have difficulty in maintaining their connections to external readout equipment, and they also increase the risk of infection during and after implantation. In this study, to read the pressure wirelessly using an MRI system, an LC resonator consisting of a spiral coil and a pressure-sensitive capacitor was designed resonate at 300 MHz which corresponds to the Larmor frequency in an external magnetic field of 7-T. In order to validate the operating principle of the fabricated device, the frequency-impedance characteristics were measured by changing the pressure. The resonance frequencies of complemented LC circuits were lower by approximately 10% than those of nonpressured conditions. After implanting these devices in a 1% agarose gel, MR images were acquired by inducing pressures close to blood pressures of 20 kPa. As a result, contrast changes in the MR images were observed around the integrated spiral coils. This result indicated that the developed flexible pressure sensor has sufficient sensitivity to measure physiological pressure such as blood pressure of 20 kPa wirelessly in the body. In the future, quantitative pressure sensing will be evaluated by comparing it to the contrast changes in MR images with flip angle mapping.

DOI： 10.1109/EMBC.2015.7319066

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記述言語：日本語  

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記述言語：日本語   出版者・発行元：一般社団法人 日本生体医工学会  

During a cardiac surgery for cardiomyopathy or infarction, the position of lesion has been identified by palpation, myocardiogram examination or thermometry scan. However, technical limitations such as relatively long examination time and less spatial resolution have remained. In this study, to detect the accurate position of lesion quickly even on a surface of beating heart, we developed an ultra-flexible electrode array for myocardiogram measurement. A gold patterned electrode array of 50-nm-thickness was fabricated on a 1.4-&mu;m-thick PEN film and insulated with an additional Parylene-C layer of 1.5-&mu;m-thickness. The living heart surface of a Wistar rat (male, 300g) was exposed under isoflurane anesthesia. Attaching the flexible electrodes to that, the distribution of myocardiogram was measured. The measured result successfully described the distribution of cardiac action potential at the heart surface. The ultra-flexibility of electrode device prevents damage of the heart and surrounding organs like lung. In the future, an implantable flexible electrode device equipped with sensors and amplifier with flexible transistors will be developed for clinical applications.

DOI： 10.11239/jsmbe.53.S269_02

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記述言語：日本語   出版者・発行元：一般社団法人 日本生体医工学会  

Effects of long-term continuous electric stimulation on angiogenesis have been investigated for potential therapeutic applications. Evaluation of the effect has been carried out mainly through observation of extracted tissues after the long-term stimulation. The purpose of this study is to observe angiogenesis in vivo under application of electric stimulations. We developed an implantable device equipped with a scaffold, CMOS-camera and electrodes for real-time observation. The scaffolds and electrodes were placed in 2 experimental chambers. The device has 1.3 mega pixel CMOS sensor, auto-focus lenses and white LED as light source. The electrode was consisted of 1.4&micro;m PET film as substrate and 50nm gold as conductor. The device was implanted under the skin of a goat, and get picture and applied the electric stimulations for 60 days. The electric stimulations were applied with a 60 kHz sinusoidal waveform and a current density of 300 uA/mm2. Angiogenesis occurred in 0.1 mm/day in the non-stimulated device, while no angiogenesis was observed in the device without stimulation. These results show that electric stimulations of this condition are effective for suppressing angiogenesis.

DOI： 10.11239/jsmbe.53.S229_02

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記述言語：英語  

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記述言語：日本語   出版者・発行元：一般社団法人 日本生体医工学会  

Electrodes for temporary cardiac pacing are used to monitor and suppress arrhythmia. The present clip-on electrodes are reliably fixed on the heart but make injuries on the heart. Development of noninvasive temporary pacing electrodes is an approach to solve this problem. In this study, a flexible electrode composed of polymer film and adhesive conductive gel for stable contact to the heart is fabricated. A flexible electrode consisted of 50-&mu;m-thick polyimide film as a substrate, 50-nm-thick gold or platinum on a substrate as a pair of conductive paths and terminals, and 0.5-&mu;m-thick palyrene film as an insulating layer. The gel was composed by saline, polyvinyl alcohol (10wt%) as an adhesive agent, and sodium polyacrylate (5wt%) as a gelling agent. Adhesive resistance of this gel reached 0.7N which was almost equal to that of a representative commercial solid paste. We measured ECG of a goat using this device. The wave-form demonstrating 96 peaks per minute was obtained.

DOI： 10.11239/jsmbe.53.S269_01

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記述言語：日本語   出版者・発行元：一般社団法人 日本生体医工学会  

Sensor less estimation of pressure and flow was important subject for developing total artificial heart. However, estimated value is affected by viscosity change that occurs in living body usually. In this study, we proposed a novel method for viscosity estimation utilizing the table estimation method. Within short time like one plus, change in blood viscosity and peripheral resistance is considered to be little between systolic or diastolic phases. In the same viscosity, different resistance curves never cross. These characteristics suggest that viscosity could be estimated by motor information of systolic and diastolic phases. The helical flow pump was connected to the mock circulation and tables were created by using known viscosity fluids. Standard data were measured with continuous and pulsatile modes. Estimation accuracy was examined with two continuous-flow conditions regarded to systolic and diastolic phases. There fould a tendency that the more difference two conditions were, the more accurate estimation could be possible. Almost the same results were obtained on pulsatile mode. Possibility of the proposed estimation method was demonstrated.

DOI： 10.11239/jsmbe.53.S197_03

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記述言語：英語  

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：NATURE PUBLISHING GROUP  

To measure electrophysiological signals from the human body, it is essential to establish stable, gentle and nonallergic contacts between the targeted biological tissue and the electrical probes. However, it is difficult to form a stable interface between the two for long periods, especially when the surface of the biological tissue is wet and/or the tissue exhibits motion. Here we resolve this difficulty by designing and fabricating smart, stress-absorbing electronic devices that can adhere to wet and complex tissue surfaces and allow for reliable, long-term measurements of vital signals. We demonstrate a multielectrode array, which can be attached to the surface of a rat heart, resulting in good conformal contact for more than 3 h. Furthermore, we demonstrate arrays of highly sensitive, stretchable strain sensors using a similar design. Ultra-flexible electronics with enhanced adhesion to tissue could enable future applications in chronic in vivo monitoring of biological signals.

DOI： 10.1038/ncomms6898

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：SPRINGER JAPAN KK  

The total artificial heart (TAH) requires physiological control to respond to the metabolic demand of the body. To date, 1/R control is a single physiological control method that can control venous pressure. To realize an implantable 1/R control system, we are developing a new pressure measuring method using absolute pressure sensor. To find a method for absolute pressure sensor, which went well without calibration, concept of left atrial pressure (LAP) estimation using its pulsatile amplitude was proposed. Its possibility was investigated with two long-term survived goats whose hearts were replaced with the helical flow TAHs. In manual control condition, there existed a positive relation between mean LAP (mLAP) and normalized pulsatile amplitude (NPA). Percent systole revealed not to affect the relationship between mLAP and NPA. Dispersion was observed between different pulse rates. As for cardiac output difference (QLD) that is the difference of flow rate between systolic and diastolic phases, similar results were obtained except in low QLDs. In the 1/R control condition, relatively high correlation between mLAP and NPA could be obtained. In estimation of mLAP using the correlating function of individual goat, fairly good correlation was obtained between measured mLAP and estimated mLAP. Despite that further studies are necessary, it was demonstrated that the concept of the LAP estimation could be possible.

DOI： 10.1007/s10047-014-0788-7

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC  

A 64-channel surface electromyogram (EMG) measurement sheet (SEMS) with 2 V organic transistors on a 1 mu m-thick ultra-flexible polyethylene naphthalate (PEN) film is developed for prosthetic hand control. The surface EMG electrodes must satisfy the following three requirements; high mechanical flexibility, high electrode density and high signal integrity. To achieve high electrode density and high signal integrity, a distributed and shared amplifier (DSA) architecture is proposed, which enables an in-situ amplification of the myoelectric signal with a fourfold increase in EMG electrode density. In addition, a post-fabrication select-and-connect (SAC) method is proposed to cope with the large mismatch of organic transistors. The proposed SAC method reduces the area and the power overhead by 96% and 98.2%, respectively, compared with the use of conventional parallel transistors to reduce the transistor mismatch by a factor of 10.

DOI： 10.1109/TBCAS.2014.2314135

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Japan Soc. of Med. Electronics and Biol. Engineering  

Assistive communication devices are available for deaf or hard-of-hearing (DHH) individuals. However, these devices often are only for face-to-face use and cannot provide text or symbol equivalents of verbal communication such as warnings, orders or requests. This paper suggests a new solution by a remote communication system based on an Android Smartphone for text communication from a family member or a health care worker to a DHH individual. This system was found to be good for home use from the viewpoints of coverage, cost, and simplicity.

DOI： 10.11239/jsmbe.52.O-446

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記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Japan Soc. of Med. Electronics and Biol. Engineering  

The purpose of this research is to establish sterilization method and preservation method for long time of hybrid material. Hybrid material was freeze dried and hybrid material was sterilized by four methods.The sterilization methods are autoclave, dry heat, ethylene oxide gas(EOG), and hydrogen peroxide gas plasma.We evaluate sterilization to compare structural change before and after the sterilization by microscopic observation.In autoclave and dry heat, hybrid materials were change color and transformation by heat.In these results, EOG sterilization is most suitable method of the hybrid material.Next, It is planed evaluate this sterilization method by cell culturing and animal experiment.

DOI： 10.11239/jsmbe.52.O-555

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記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Japan Soc. of Med. Electronics and Biol. Engineering  

The purpose of this study is to investigate the effect of electrical stimulation on angiogenesis. We developed an implantable camera device which observes blood vessels in animal bodies with stimulating electrodes. This device was implanted under the goat skin for 60 days. Electrical stimulations were applied with a sinusoidal wave of 60 kHz and a current density of 300 uA/mm2. Angiogenesis was clearly observed in the non-stimulated chamber, while angiogenesis did not occur in the stimulated chamber. These results show that electrical stimulation of this condition has effective to suppress angiogenesis.

DOI： 10.11239/jsmbe.52.O-249

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記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Japan Soc. of Med. Electronics and Biol. Engineering  

The helical flow pump (HFP) for the total artificial heart (TAH) has been developed. In the recent hemolysis test, normalized index of hemolysis (NIH) of HFP is 0.71 times of BioPump (BPX-80). Comparing to blood pumps in clinical field, further improvement is still significant task. Computational fluid dynamics analysis is carried out to determine risky area of the hemolysis in the flow passage except hydrodynamic bearing. And shear stress and duration along the stream lines which is regarded as a path of Red blood cells are analyzed. As the result, 0 deg and 180 deg of rotational angle where confluent or split-flow with large flow speed difference are clarified as risky area of hemolysis.

DOI： 10.11239/jsmbe.52.O-535

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Japan Soc. of Med. Electronics and Biol. Engineering  

Hemolysis test has been used to evaluate medical device safety and hemocompatibility. However, the influence of measuring plasma hemoglobin concentration could be very complex, making it difficult to get reproducible hemolysis index. The purpose of this study is to compare the variation of plasma hemoglobin concentration by using 3 kinds of anticoagulants (EDTA-2Na, heparin, sodium citrate), and the influence of temperatures(25°C and 37°C). As a means to measure hemoglobin concentration, Cripps method and Porter method were used. The results showed that no significant decrease in hemoglobin concentration was observed in heparin and sodium citrate. However, the hemoglobin concentration in EDTA-2Na decreased. At 37 °C, the decrease in hemoglobin concentration was also observed. Meanwhile, no significant decrease in hemoglobin concentration was observed at 25°C. The reason for the decrease in hemoglobin concentration is considered to be the formation of methemoglobin.

DOI： 10.11239/jsmbe.52.O-544

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記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Japan Soc. of Med. Electronics and Biol. Engineering  

Measurement of pressure within blood vessels will be valuable for the diagnoses of aneurysm. However, implantation of a conventional pressure sensor equipped with power and signal cables causes difficulties in surgery and risk of infection after implantation.In this study, we developed a wireless, implantable, and flexible pressure sensor. An MRI system reads out the sensor output.The proposed wireless sensor is based on an LC resonance circuit with a spiral coil and a pressure-sensitive capacitor.The pressure-dependence of the circuit affects the fields arising from the spiral coil, changing the nearby sample magnetization, and thus can be observed as an MRI signal variation.We fabricated a prototype sensor using silicone elastomer as dielectric with gold wiring. The maximum change in the capacitance was 8% under external pressure of 20 kPa.A change in thickness of dielectric elastomer caused the capacitance change, resulting in a detectable change in MRI.

DOI： 10.11239/jsmbe.52.O-409

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記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Japan Soc. of Med. Electronics and Biol. Engineering  

Data handling of medical devices are one of the most important things under home medical care. We examined data handling of total artificial heart (TAH) under home medical care based on animal experiments of the TAH.A system that collecting and storing all data of total artificial heart and experimental animal and notifying only emergency data as alarm was developed. The datum was stored almost in real-time and can be accessed through the Internet. We could handle the data from remote by the developed system. The most important and difficult point on the data dealing with under home medical care is notifying of the data. The data must be layered according to the priority and collected almost in real-time. On development of the TAH, data handling under home medical care must be concerned.

DOI： 10.11239/jsmbe.52.SY-87

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掲載種別：研究論文（学術雑誌）  

© 2014, Japan Soc. of Med. Electronics and Biol. Engineering. All rights reserved. We have been developing a total artificial heart (TAH) named the helical flow TAH (HFTAH) using helical flow pumps (HFPs). The HFTAH was designed to have a small size with enough performance, good durability and good anatomical fitting. The left and right HFPs were designed separately so that they could be applied also for bi-ventricular or single ventricular assist devices. The elemental technologies are hydrodynamic levitation impeller, 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer coating and absolute pressure sensor integration in the pump. The HFTAH was implanted in goats and 100 days survival was obtained. With animal experiments, the problem that hydrodynamic bearing touched to the shaft and was worn by the sucking effect was occurred. However, the potential of the HFTAH was demonstrated. We are expecting that the HFTAH would be an excellent total artificial heart as a next generation device.

DOI： 10.11239/jsmbe.52.OS-1

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Japan Soc. of Med. Electronics and Biol. Engineering  

For the emergency medical care of severe lung and/or heart failure patients, we have been developing an emergency life support system (ELSS) that is compact heart-lung equipment. In this study, a novel built-in blood pump named the sequential flow pump (SFP) for the ELSS was proposed and its performance was analyzed with a computational fluid dynamics and experimental models. The SFP is a special centrifugal pump in which centrifugal force is given sequentially two times to the fluid with a single impeller. The computational and experimental models were designed to have the impeller with about 60 mm in diameter. The result showed that the target performance of 5 l/min against 350 mmHg of pressure load could be achieved with 3300 rpm of rotational speed, which was lower speed than that of the conventional centrifugal pumps. The potential of the SFP was demonstrated.

DOI： 10.11239/jsmbe.52.O-537

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掲載種別：研究論文（学術雑誌）  

© 2014, Japan Soc. of Med. Electronics and Biol. Engineering. All rights reserved. The total artificial heart (TAH) has been expected to solve some problems of heart transplant. We have been developing the TAH using helical flow pump (HFP). The HFP has a hydrodynamic bearing and can eject pulsatile flow. To date, satisfactory pump was developed for the left pump, however for the right pump, there remains the problem in the hydrodynamic bearing. The purpose of this study was to investigate the right pump in order that hydrodynamic bearing functions well in pulmonary circulation and to achieve an improvement in the right pump. Based on the investigation, among various parameters of the pump structure, the vane of the impeller was decided to be smaller. The performance of the improved right pump showed that the pump could work in wider range than the original pump, which was more suitable for pulmonary circulation. In animal experiment, the improved right pump worked in a stable condition. However, the problem of accuracy in dimension of the bearings was found, which should be improved rapidly.

DOI： 10.11239/jsmbe.52.O-532

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記述言語：日本語   掲載種別：研究論文（学術雑誌）  

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：WILEY-V C H VERLAG GMBH  

A unique form of adaptive electronics is demonstrated, which change their mechanical properties from rigid and planar to soft and compliant, in order to enable soft and conformal wrapping around 3D objects, including biological tissue. These devices feature excellent mechanical robustness and maintain initial electrical properties even after changing shape and stiffness.

DOI： 10.1002/adma.201400420

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：SPRINGER JAPAN KK  

The helical flow pump (HFP) was invented to develop a total artificial heart at the University of Tokyo in 2005. The HFP consists of the multi-vane impeller involving rotor magnets, a motor stator and pump housing having double-helical volutes. To investigate the characteristics of the HFP, computational fluid dynamics analysis was performed. Validation of the computational model was performed with the data of the actual pump. A control computational model in which the vane area corresponded approximately to that of the actual pump was designed for the parametric study. The parametric study was performed varying the vane height, vane width and helical volute pitch. When the vane height was varied from 0.5 to 1.5 times that of the control computational model, the H-Q (pressure head vs. flow) and efficiency curves were translated in parallel with the vane height. When the vane height was two and three times that of the control computational model, the profile of these curves changed. From the results, the best proportion for the vane was considered to be a vane height between 1.5 and 2 times the vane width. The effect of vane width was not very strong compared to that of the vane height. A similar tendency in vane height was observed by varying the helical volute pitch. The best helical volute-pitch size is considered to be between 1.5 and 2 times the vane width. Although further study is necessary to determine the best values for these parameters, the characteristics of the pump parameters in the HFP could be approximately clarified.

DOI： 10.1007/s10047-013-0739-8

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掲載種別：研究論文（学術雑誌）  

For the diagnosis of cancer metastasis, lymph nodes are selectively removed. In this study, we developed a magnetic probe for intraoperatively detecting accumulation of magnetic fluid. We manufactured a magnetic probe consisting of a permanent magnet and a Hall-effect sensor, and investigated the sensitivity. The results agreed well with the numerical results. In addition, a prototype probe detected 1.6 mL magnetic fluid located at 30 mm from the probe head. © 2014 The Institute of Electrical Engineers of Japan.

DOI： 10.1541/ieejfms.134.266

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記述言語：英語   掲載種別：研究論文（国際会議プロシーディングス）   出版者・発行元：IEEE  

Measuring the local pressure in blood vessels is valuable in the postoperative monitoring of aneurysms. However, implanting a conventional pressure sensor equipped with power and signal cables causes difficulties during the operative procedure and carries a risk of infection after the implantation. In this study, we developed a wireless, implantable, and flexible pressure sensor. A magnetic resonance imaging (MRI) system reads out the sensor output. The proposed wireless sensor is based on an LC resonant circuit with a spiral coil and a pressure-sensitive capacitor. The pressure-dependence of the capacitance affects the magnetic field produced by the spiral coil, changing the magnetization of the nearby sample that can be observed as a signal variation by MRI. We fabricated a prototype sensor using a capacitor with a silicone elastomer as the dielectric and a spiral coil made of gold. The maximum change in the capacitance was 8% under an external pressure of 20 kPa. A change in the thickness of the dielectric elastomer caused the capacitance to change, resulting in a signal variation detectable by MRI.

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記述言語：日本語   掲載種別：研究論文（学術雑誌）  

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記述言語：日本語   掲載種別：研究論文（学術雑誌）  

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出版者・発行元：IEEE  

DOI： 10.1109/ISSCC.2013.6487656

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記述言語：英語   出版者・発行元：Japanese Society for Medical and Biological Engineering  

DOI： 10.11239/jsmbe.51.R-229

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掲載種別：研究論文（国際会議プロシーディングス）   出版者・発行元：IEEE  

DOI： 10.1109/EMBC.2013.6610102

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出版者・発行元：IEEE  

DOI： 10.1109/EMBC.2013.6609589

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記述言語：英語   掲載種別：研究論文（国際会議プロシーディングス）   出版者・発行元：IEEE  

Development have been achieved of a new blood pump for next generation Percutaneous Cardio-Pulmonary Support (PCPS) system and a novel surface coating method for silicone membrane hollow fiber by physical adsorption using a copolymer composed of a 2-Methacryloyloxyethyl phosphorylcholine (MPC) unit and a hydrophobic unit. The new blood pump, named the Troidal Convolution Pump (TCP), is based on the principle of a cascade pump and perfused 5 L/min and 350 mmHg at 2450 rpm. The novel copolymer composed of 30% MPC unit and 3-(methacryloyloxy) propyltris (trimethylsiloxy) silane (MPTSSi) unit (PMMSi30) was the most suitable molecular design on a silicone surface. The PMMSi30 coated surface adsorbed 7.2 % as much protein a non-coated surface adsorbed.

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掲載種別：研究論文（学術雑誌）  

Conventional functional magnetic resonance imaging (MRI) has a relatively low temporal resolution, because this method does not measure neuronal activity itself but observes blood flow. The detection of local magnetic fields in close proximity to the activating area leads to a novel functional MRI with ultrahigh temporal resolution. Magnetic fields arising from neuronal electrical activities are very weak. The aim of this study is to evaluate the feasibility of detecting neuronal magnetic fields using MRI. The threedimensional potential distribution in the rat brain was measured using a microelectrode array. Somatosensory evoked potentials were recorded during hind paw stimulation with a spatial resolution of 300 μm. The intensity of the magnetic flux density was calculated from the measured result, and was estimated at 2.84 pT. Estimation of the theoretical limit of MRI sensitivity suggested that the calculated magnetic flux density was within the detectable range of MRI. © 2013 The Institute of Electrical Engineers of Japan.

DOI： 10.1541/ieejfms.133.376

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出版者・発行元：IEEE  

DOI： 10.1109/EMBC.2013.6610103

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掲載種別：研究論文（国際会議プロシーディングス）  

The identification of the sentinel lymph nodes that cause tumor metastasis is important in breast cancer therapy. The detection of magnetic fluid accumulating in the lymph nodes using a magnetic probe allows surgeons to identify the lymph nodes. In this study, we carried out numerical simulations and experiments to investigate the sensitivity and basic characteristics of a magnetic probe consisting of a permanent magnet and a small magnetic sensor. The measured magnetic flux density arising from the magnetic fluid agreed well with the numerical results. In addition, the results helped realize an appropriate probe configuration for achieving high sensitivity to magnetic fluid. A prototype probe detected magnetic fluid located 30 mm from the probe head. © 2013 IEEE.

DOI： 10.1109/EMBC.2013.6610791

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：SPRINGER JAPAN KK  

The helical flow pump (HFP) is a novel rotary blood pump invented for developing a total artificial heart (TAH). The HFP with a hydrodynamic levitation impeller, which consists of a multi-vane impeller involving rotor magnets, stator coils at the core position, and double helical-volute pump housing, was developed. Between the stator and impeller, a hydrodynamic bearing is formed. Since the helical volutes are formed at both sides of the impeller, blood flows with a helical flow pattern inside the pump. The developed HFP showed maximum output of 19 l/min against 100 mmHg of pressure head and 11 % maximum efficiency. The profile of the H-Q (pressure head vs. flow) curve was similar to that of the undulation pump. Hydrodynamic levitation of the impeller was possible with higher than 1,000 rpm rotation speed. The normalized index of the hemolysis ratio of the HFP to centrifugal pump (BPX-80) was from 2.61 to 8.07 depending on the design of the bearing. The HFP was implanted in two goats with a left ventricular bypass method. After surgery, hemolysis occurred in both goats. The hemolysis ceased on postoperative days 14 and 9, respectively. In the first experiment, no thrombus was found in the pump after 203 days of pumping. In the second experiment, a white thrombus was found in the pump after 23 days of pumping. While further research and development are necessary, we are expecting to develop an excellent TAH with the HFP.

DOI： 10.1007/s10047-012-0659-z

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：WILEY-BLACKWELL  

It is desirable to obtain the maximum assist without suction in ventricular assist devices (VADs). However, high driving power of a VAD may cause severe ventricle suction that can induce arrhythmia, hemolysis, and pump damage. In this report, an appropriate VAD driving level that maximizes the assist effect without severe systolic suction was explored. The target driving level was set at the boundary between low driving power without suction and high driving power with frequent suction. In the boundary range, intermittent mild suction may occur. Driving power was regulated by the suction occurrence. The normal-suction boundary control method was evaluated in a female goat implanted with an undulation pump ventricular assist device (UPVAD). The UPVAD was driven in a semipulsatile mode with heartbeat synchronization control. Systolic driving power was adjusted using a normal-suction boundary control method developed for this study. We confirmed that driving power could be maintained in the boundary range. Occurrences of suction were evaluated using the suction ratio. We defined this ratio as the number of suction occurrences divided by the number of heartbeats. The suction ratio decreased by 70% when the normal-suction boundary control method was used.

DOI： 10.1111/j.1525-1594.2012.01451.x

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：WILEY-BLACKWELL  

Animal experiments using a total artificial heart in a goat are not easy to perform. The fourth model of the undulation pump total artificial heart (UPTAH4), which was designed to perform a long- term physiological experiment including pulsatile and nonpulsatile TAH operations with a conductance- and arterial pressurebased control method named 1/R control, was implanted in 31 goats weighing 38.5 to 60.4 kg (average of 46.8 kg). The 1/R control is a physiological flow control method of TAH developed with a conductance (1/R: reciprocal of a resistance) parallel circuit model. The survival periods were from 0.1 to 153 days (average of 14.5 days). The causes of termination were postoperative bleeding in eight goats, respiratory failure in five goats, device failure in 14 goats, dissected aneurysm in two goats, and thrombus in one goat. The thrombus case was the longest surviving goat. The respiratory failure tended to occur when the extracorporeal circulation time was prolonged. Autotransfusion was effective for the prolongation of survival time. The left- right balance control and the suction control were performed successfully in all goats. The 1/R control was performed for a long time in five goats that survived for more than 1 month. With three goats that survived for 48, 52, and 53 days mainly with the pulsatile mode, the 1/R control was stable. With a goat that survived for 73 days, the nonpulsatile mode with the 1/R control could be tested for 3 weeks. With the longest surviving goat that was maintained mainly with the pulsatile mode, the 1/R control was unstable, possibly due to the mismatching of the response time of the control system between the computer and the body. However, liver and kidney functions were almost normal, and the total protein level recovered. Further study to stabilize the 1/R control in the UPTAH is necessary.

DOI： 10.1111/j.1525-1594.2011.01318.x

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：SPRINGER TOKYO  

Significant progress in the development of implantable ventricular assist devices using continuous-flow blood pumps has been made recently. However, a control method has not been established. The blood pressure in the inflow cannula (inlet pressure) is one of the candidates for performing an adequate control. This could also provide important information about ventricle sucking. However, no calibration method for an inlet pressure sensor exists. In this study, an automatic calibration algorithm of the inlet pressure sensor from the pressure waveform at the condition of ventricle sucking was proposed. The calibration algorithm was constructed based on the consideration that intrathoracic pressure could be substituted for atmospheric pressure because the lung is open to air. We assumed that the inlet pressure at the releasing point of the sucking would represent the intrathoracic pressure, because the atrial pressure would be low owing to the sucking condition. A special mock circulation system that can reproduce ventricle sucking was developed to validate the calibration algorithm. The calibration algorithm worked well with a maximum SD of 2.1 mmHg for 3-min measurement in the mock circulation system. While the deviation was slightly large for an elaborate calibration, it would still be useful as a primitive calibration. The influence of the respiratory change and other factors as well as the reliability of the calibration value should be investigated with an animal experiment as a next step.

DOI： 10.1007/s10047-011-0556-x

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：WILEY-BLACKWELL PUBLISHING, INC  

We developed an in vivo insert molding technique to form tissue-derived biomaterials into the desired shape, and with sufficient strength and durability, for use in artificial organs. Molds of acrylic resin with inserted velour cloth were implanted under the skin of goats to form a circular leaflet for a jellyfish valve. The valve leaflets were successfully produced in the molds after 17-60 days. Dense connective tissue covered the velour cloth, and loose connective tissue was formed within it. Tissue was radially formed from the hole in the mold. The tissue was simultaneously formed and shrunk. It is necessary to increase the connected portion between the tissue inside and outside the mold so that the tissue can completely cover the inserted materials without shrinkage.

DOI： 10.1111/j.1525-1594.2010.00997.x

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記述言語：英語   掲載種別：研究論文（国際会議プロシーディングス）   出版者・発行元：IEEE  

The undulation pump ventricular assist device (UPVAD) is a small implantable ventricular assist device using an undulation pump. The UPVAD can produce pulsatile flow by changing the motor rotation speed of the UPVAD. Because the undulation pump is a volume displacement type pump, the inflow sucking occurs easily. The purpose of this study is to develop a suitable control method for the UPVAD. The UPVAD inflow cannula equipped with an implantable pressure sensor was inserted into the ventricle. Therefore, pressure variation that synchronized with the natural heartbeat and negative pressure spike caused the inflow sucking were observed. By changing the motor rotation speed that responded to the inflow pressure, the UPVAD could synchronize with the natural heartbeat and the UPVAD could generate a co-pulse assist flow. The inflow sucking could be released by reducing the motor rotation speed, if the inflow sucking was detected. The newly developed control method exhibited superior characteristics than existing ones due to high immunity against pressure sensor drift. The assist flow could be increased more than 15% and the inflow sucking occurrence could be decreased with this control method. The UPVAD could generate the suitable assist flow with the developed control method.

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：SPRINGER TOKYO  

A total artificial heart (TAH) using continuous flow pumps is promising for size reduction of the device; however, the role of pulsatility in TAHs has been a subject of great debate. Additionally, it is unclear whether, in a nonpulsatile TAH, a physiological control method such as 1/R control can keep the experimental animal in good condition. To realize a nonpulsatile TAH with 1/R control, the artificial valves were removed from undulation pump total artificial hearts (UPTAHs), which can produce both pulsatile and nonpulsatile flows using a single device. The UPTAHs were implanted into 18 goats, and 4 goats survived for more than 1 month. Three weeks of long-term nonpulsatile TAH operation could be tested in the goat that survived for 72 days, and it was proved that 1/R control is possible not only with a pulsatile TAH but also with a nonpulsatile TAH. The general condition of the goat and its organ function did not change on the application of nonpulsatile mode. Cardiac output and arterial pressure changed with the condition of the goat in pulsatile and also in nonpulsatile modes, and the changes seemed almost identical. However, the sucking effect of the atria was very significant in nonpulsatile mode, resulting in hemolysis. Therefore, nonpulsatile TAHs under 1/R control are considered to be inadequate unless some pulsatility can be introduced to avoid fatal sucking effects and to ensure sufficient inflow. During nonpulsatile operation, regular fluctuations were sometimes found in the aortic pressure, and these were caused by the periodic sucking effect in the left atrium that was possibly influenced by respiratory changes.

DOI： 10.1007/s10047-008-0434-3

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：WILEY-BLACKWELL  

We have developed internal battery systems for driving an undulation pump ventricular assist device using two kinds of lithium ion rechargeable batteries. The lithium ion rechargeable batteries have high energy density, long life, and no memory effect; however, rise in temperature of the lithium ion rechargeable battery is a critical issue. Evaluation of temperature rise by means of numerical estimation is required to develop an internal battery system. Temperature of the lithium ion rechargeable batteries is determined by ohmic loss due to internal resistance, chemical loss due to chemical reaction, and heat release. Measurement results of internal resistance (R-cell) at an ambient temperature of 37 degrees C were 0.1 Omega in the lithium ion (Li-ion) battery and 0.03 Omega in the lithium polymer (Li-po) battery. Entropy change (Delta S) of each battery, which leads to chemical loss, was -1.6 to -61.1 J/(mol.K) in the Li-ion battery and -9.6 to -67.5 J/(mol.K) in the Li-po battery depending on state of charge (SOC). Temperature of each lithium ion rechargeable battery under a discharge current of 1 A was estimated by finite element method heat transfer analysis at an ambient temperature of 37 degrees C configuring with measured R-cell and measured Delta S in each SOC. Results of estimation of time-course change in the surface temperature of each battery coincided with results of measurement results, and the success of the estimation will greatly contribute to the development of an internal battery system using lithium ion rechargeable batteries.

DOI： 10.1111/j.1525-1594.2007.00415.x

Web of Science

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記述言語：日本語   掲載種別：研究論文（学術雑誌）  

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担当区分：筆頭著者   記述言語：日本語   掲載種別：研究論文（学術雑誌）  

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記述言語：日本語   出版者・発行元：JAPANESE SOCIETY FOR ARTIFICIAL ORGANS  

DOI： 10.11392/jsao1972.35.2_S115

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記述言語：日本語   掲載種別：研究論文（学術雑誌）  

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担当区分：筆頭著者   記述言語：日本語   掲載種別：研究論文（その他学術会議資料等）  

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

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記述言語：日本語   出版者・発行元：つくば : [科学情報出版]  

CiNii Books

CiNii Research

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その他リンク： https://ndlsearch.ndl.go.jp/books/R000000004-I031350010

記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

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記述言語：日本語   出版者・発行元：公益社団法人 日本生体医工学会  

&lt;p&gt;生体内で使用するデバイスやセンサは長期間生体内で使用すると機能や感度が低下する。生体の防御機能である異物反応により、機能表面にタンパク吸着や血管新生が生じ、デバイスの本来のターゲットまでの距離が伸長してしまうことが要因である。そこで、電気刺激により機能表面の生体反応を制御することを起草し、生体内で観察することを試みた。本研究のゴールは電気刺激によって血管新生を制御することであり、特に本発表では電気刺激が血管新生にどのような影響を与えるかについて生体内で観察することを目的とした。血管を誘導し申請を促す足場とCMOS撮像素子と電極から構成した観察デバイス（37×44×22mm）を開発した。デバイスは動物の皮下の広背筋近傍に埋込み、1時間おきに画像を取得した。2つのチャンバーのうち一方にだけ電気刺激を付加した。60日間の実験の結果、電気刺激を付加しなかった系において血管は94.7um/dayの早さで新生した。電気刺激を付加した系では血管は新生しなかったが、電気刺激を停止したところ血管が新生された。これらの結果から本条件における電気刺激は血管新生を阻害する効果があり、任意制御の可能性を示した。また今後は本結果を発展させることで、腫瘍の形成抑制や、角膜血管形成の治療として役立てることが考えられる。さらに様々な電流密度で実験を行い、血管新生阻害の閾値となる電流を調査する予定である。&lt;/p&gt;

DOI： 10.11239/jsmbe.52.O-249

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

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記述言語：日本語   出版者・発行元：[科学情報出版]  

CiNii Books

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記述言語：英語  

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記述言語：英語  

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記述言語：英語  

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記述言語：日本語   出版者・発行元：名古屋 : エリザベス・アーノルド富士財団  

CiNii Books

CiNii Research

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その他リンク： https://ndlsearch.ndl.go.jp/books/R000000004-I029340803

記述言語：日本語   出版者・発行元：公益社団法人 日本生体医工学会  

&lt;p&gt;生体を補助する人工心臓においては材料と生体の境界における血栓形成が課題であり、重篤な脳血管障害を引き起こす可能性があるために解決すべき重要な問題となっている。我々は、人工材料に生体組織を誘導することで生体が本来持つ抗血栓性と人工材料が持つ機械的強度を併せ持つ新たな材料を開発することを起草し、この材料を用いて機械と生体との境界をシームレスに接続問題の解決を試みた。本発表では補助人工心臓用の脱血カニューレをハイブリッド材料で作製し、材料と心臓との癒合と、材料表面の血栓形成について観察を行った。生体組織を誘導する人工材料の足場にはポリエステルを用いた。足場を成形用の樹脂型に内挿した上で生体の皮下に植え込み、生体組織を誘導した。免疫拒絶反応を抑制することを目的として摘出後に1%SDS溶液を用いて脱細胞処理を施し、ハイブリッド材料を得た。ハイブリッド材料を用いて作製した脱血カニューレと、東京大学が開発した補助人工心臓とをヤギに適用し3ヶ月の長期慢性動物実験を4例実施した。心臓とハイブリッド材料は心臓ときれいに癒合し、材料表面にも血栓は形成しなかった。実験終了後の組織学評価では、ハイブリッド材料にレシピエント細胞が再生し、最表面には血管内皮細胞が観察され、作製した材料の有用性が示された。&lt;/p&gt;

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記述言語：日本語   出版者・発行元：公益社団法人 日本生体医工学会  

&lt;p&gt;先天性心疾患治療でのFontan循環の血行動態改善を目的として心外導管外部からサポートする超小型小児用肺循環補助デバイスの開発を進めている。アクチュエータは、直径100μmの形状記憶合金で、70℃の通電加熱によって最大7%収縮する。体内埋め込み時のアクチュエータ駆動によるデバイスの発熱が課題であり、デバイスの安定した運用のために熱応答の解明と排熱機構の開発が不可欠である。そこで、本研究では、デバイスの伝熱特性の解明により、ヒートパイプを応用したアクチュエータでの発熱を大血管へと排熱する冷却システムを開発するため、デバイス伝熱応答の検討および排熱機構の基本設計を行った。 現在開発中のプロタイプ補助装置を、病態モデル動物実験により生体内での駆動試験を行い、デバイス駆動時の発熱の影響を計測した。得られた結果から、デバイスに必要な冷却温度差について検討し、ヒートパイプ排熱機構の基本設計を行った。 生体内でのデバイス駆動試験の結果より、最大発熱部で45℃までの熱上昇がみられた一方で、人工血管と接する部位で温度上昇は抑えられた。デバイス本体での最大温度と体温の温度差から、ヒートパイプ設計のための封入気体の選定と封入圧を検討した。 小児用肺循環補助デバイスのためのヒートパイプ冷却装置の基礎検討を行った。今後は、血管排熱部、デバイス吸熱部を有する冷却機構を試作し、実機試験系で性能評価を進める。&lt;/p&gt;

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記述言語：日本語   出版者・発行元：公益社団法人 日本生体医工学会  

<p>本研究の目的は高血圧患者の腎神経表面温度を抑制可能な埋込型腎神経冷却デバイスの改良である。我々は埋込型腎神経冷却デバイスのコンセプトを実現するためにペルチェ素子とヒートパイプを組み合わせた設計を行った。埋込型デバイスはa) 3.94mmの厚さと3.2mm×3.2mmの冷却面を有するペルチェ素子、b) 6mmの直径と250mmの長さを有するヒートパイプとを機械的及び熱的にペルチェ素子の放熱面に接合して作製した。また、我々はペルチェ素子の供給電力における温度変化をサーモカメラで観測し作製した冷却デバイスの冷却性能を調べた。結果として、冷却面温度はヒートパイプを用いることで制御可能な温度を示すことが示唆された。</p>

DOI： 10.11239/jsmbe.55Annual.236

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記述言語：日本語   出版者・発行元：三井住友海上福祉財団  

CiNii Books

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記述言語：日本語   出版者・発行元：公益社団法人 日本生体医工学会  

<p>嚥下機能の評価は嚥下造影検査、反復唾液嚥下テスト、聴診所見などによって行われている。これらの機能性評価は、外部からの詳細を観察することによって行われる。嚥下挙動時には、味覚や食味といった感性要因も作用する。本研究では、食物の性状や特性が及ぼす嚥下時の咽喉挙動の変化を非接触画像解析で行い、食味食感を嚥下動作中に解析した。深度情報取得が可能な非接触カメラを用いて食物摂取時の咽喉部を外部から計測し、得られた深部情報を含む動画像を解析し、咽喉部皮膚表面形状の変化から嚥下動作の検出を試みた。健常成人を対象として、室温の飲料水と生理食塩水の飲水時の嚥下挙動を観察した。さらに、パンのペーストとしてオリーブオイルおよび調整した食用ゼラチンを塗布した食品サンプルの摂食時の嚥下挙動を非接触で計測した。計測した3次元深度画像情報を解析し、対象領域について15fpsの深度変化を調べ、咽喉部皮膚の形状変化が嚥下動作と一致する結果を得た。さらに、嚥下動作に伴う咽喉部皮膚の形状変化を周波数解析し、摂食時の流動性と官能評価に基づく食味に対して、嚥下挙動の変化の検出を定量的に示しうることが示された。</p>

DOI： 10.11239/jsmbe.55Annual.481

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記述言語：日本語   出版者・発行元：日本循環制御医学会  

DOI： 10.11312/ccm.37.185

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本統合医療学会  

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記述言語：日本語   出版者・発行元：(一社)日本統合医療学会  

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記述言語：日本語   出版者・発行元：(一社)日本統合医療学会  

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記述言語：日本語   出版者・発行元：(一社)日本統合医療学会  

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

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記述言語：日本語   出版者・発行元：(一社)ライフサポート学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)ライフサポート学会  

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記述言語：日本語   出版者・発行元：(一社)ライフサポート学会  

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記述言語：日本語   出版者・発行元：(一社)ライフサポート学会  

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記述言語：日本語   出版者・発行元：(一社)ライフサポート学会  

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記述言語：日本語   出版者・発行元：北海道外科学会  

J-GLOBAL

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記述言語：英語  

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記述言語：日本語   出版者・発行元：公益社団法人 日本生体医工学会  

<p>食道癌患者の治療のための能動型人工食道の研究開発をしている。一般的には開胸開腹を必要とする外科的治療である胃管吻合術が行われている。人工食道の開発では、生体食道の蠕動運動を高度に模擬することで、流動停滞のない食物嚥下を支援することが必要であり、本研究では生体食道の詳細な力学的特性解析を行い、人工食道の設計基礎となる非線形モデルの構築を試みた。健常成ヤギから摘出した新鮮食道を用いて、引っ張り試験を行い、その結果を用いて、構築した三要素モデルを用いて応力ひずみ関係を調べた。</p>

DOI： 10.11239/jsmbe.54Annual.S347

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記述言語：日本語   出版者・発行元：公益社団法人 日本生体医工学会  

<p>先天性心疾患での肺動脈狭窄に用いられるePTFE製肺動脈弁付導管の形状最適化をすすめている．本研究では，導管壁面にもたせた生体肺動脈基部のバルサルバ洞様のbulging sinusに着目し，その最適形状決定を目的として模擬循環での血行力学評価を行った．</p><p> 小児右心模擬循環回路は空気圧駆動右心房・右心室モデル，試験弁観測チャンバ，弾性肺血管・末梢血管抵抗モデル，静脈リザーバからなる．モデル循環圧・流量は小児右心循環の正常範囲内とし，収縮期間はそれぞれ心周期に対して15，40%，ポンプ拍動数は60，120 bpmとした．bulging sinusの深さの異なる3種（without，shallow，deep）の18 mm径ePTFE弁付導管をそれぞれ回路に接続し，作動流体には常温生理食塩水を用い，弁前後圧・流量を計測した．圧・流量データから収縮期弁前後エネルギー損失を算出した．また，高速度ビデオカメラを用いて弁葉挙動を取得し，弁開口面積の時系列変化を算出した．</p><p> 模擬循環での血行動態計測から，より深いbulging sinusを持たせたePTFE弁において損失エネルギーが低値を示した．また，deep bulgingの存在によって弁開放時流路面積が拡大し，弁閉鎖応答特性が向上した．ePTFE製肺動脈弁付導管の形状改良のため，設計パラメータとしてbulging sinus形状に着目し血行力学的効果の定量的評価を行った．本研究の展開によってePTFE弁改良の方向性を決定しうると考えられる．</p>

DOI： 10.11239/jsmbe.54Annual.S54

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記述言語：日本語   出版者・発行元：公益社団法人 日本生体医工学会  

<p>Fallot四徴症などの先天性心疾患に対する外科的治療の長期予後は著しく改善してきた。これらは外科的治療戦略の進化に伴うものが多く、国内での臨床例はePTFE製人工血管を用いたTCPCの方法で単一心室の心臓-血管系の力学的相互作用について安定した血行動態を維持できることを示している。</p><p>一方、長期にわたるTCPCの予後で、近年Fontan循環の遠隔期に肝機能障害などの末梢臓器不全が示唆されている。Fontan循環では、右心系血液循環での心臓の血流逆止弁がなく、肺動脈の圧力変動にともなって下大静脈へ逆流が生じることが知られている。</p><p>そこで、小児先天性心疾患のFontan循環を受動的に改善する新しい埋込型システムを考案し、呼吸などによって変動する肺動脈-下大静脈の血行力学的相互作用による逆流のみを選択的に抑制する装置の試作を試みている。</p><p>本研究では、これらの開発する埋込型能動式Fontan循環抵抗変動デバイスの試作評価に必要な肺循環抵抗変動を生成可能なFontan循環静脈系シミュレーションモデルの開発を目的として、生体胸腔内圧変動を模擬できる肺循環抵抗系の駆動システムを持つ管路系を設計した。今後、Fontan循環の抵抗変動デバイスを本低圧系循環シミュレーションモデルで評価し、長期埋込型システムの有効性と有用性を調べてゆく。</p>

DOI： 10.11239/jsmbe.54Annual.S16

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記述言語：日本語   出版者・発行元：公益社団法人 日本生体医工学会  

<p>現在我々は、小児先天性心疾患患者のFontan循環を補助する体内埋込み型肺循環補助装置の開発を進めている。形状記憶合金（SMA）繊維をアクチュエータとして応用し、Fontan循環での心外導管外周部に巻き付け、外部から拍動収縮する構造である。これまでに、生体での評価試験系構築のために健常成山羊を用いたFontan循環動物実験モデルを構築した。本研究では、生体内でも有効に収縮駆動可能なデバイスの構造を設計試作し、駆動試験を行い収縮特性と有用性の評価を行った。アクチュエータとして用いるSMAファイバは、通電加熱により約5-7％収縮する特性を持つ。収縮量を増幅するために、有効な拍動を行う部位と収縮量を得るスリーブ部の構成とした。滑り性が高く耐熱性のあるPTFEチューブにSMAファイバを通すことで、収縮を阻害しにくくした。スリーブ部には、ガラスファイバー製のスリーブを用い、長軸方向に収縮しにくい構造とし、拍動部にはシリコーンチューブを使用し有効な収縮と絶縁性を有する構造とした。試作したデバイスを用いて収縮駆動試験を行った。電極接続部には、シリコーン樹脂で包埋し、絶縁性を持たせた。体内埋め込み時の収縮特性試験の結果、長軸方向に巻き付け部の25%に相当する有効な収縮を得ることができた。また、Fontan循環動物モデルで小児用肺循環補助デバイスの駆動試験を実施し、体内埋め込み時にもデバイス付与によるFontan循環補助の可能性が示唆された。</p>

DOI： 10.11239/jsmbe.54Annual.S52

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記述言語：日本語   出版者・発行元：公益社団法人 日本生体医工学会  

&lt;p&gt;In this study, a bearing and motor system of the right heart pump was designed for a continuous flow total artificial heart. We evaluated the performance of the motor in the winch examination. Also, we examined the influence of the gap between the stator and the rotor under the constant drive voltage condition. The gap was changed from 1.0 mm to 2.5 mm. The motor with larger gap has higher rotational speed coefficient, and lower torque coefficient. On the other hand, the motor with smaller gap has lower rotational speed coefficient and higher torque coefficient. In shaft output, we could not find significant difference with the operational range. The motor with larger gap has lower efficiency when the torque is larger than 5.0 mNm. The motor with larger gap has higher efficiency when the torque is smaller than 5.0 mNm.&lt;/p&gt;

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記述言語：日本語   出版者・発行元：公益社団法人 日本生体医工学会  

&lt;p&gt;補助人工心臓において、脱血カニューレの心筋挿入部位周囲に血栓が形成されることが問題となっている。血栓形成の主因はカニューレの生体適合性であると考えられており、材料表面に形成される血栓と、心筋とカニューレの間隙に生じる凝血塊がクリアすべき課題である。この問題を解決すべく、新たに開発したハイブリッド材料を用いて脱血カニューレの作製を試みた。ハイブリッド材料は、人工材料と生体由来材料とを組み合わせた材料のことで、組織新生の足場となる人工材料を生体の皮下に埋め込み、生体組織と人工材料とを一体化させることにより得る。作製した材料に脱細胞化処理を行うことで細胞外マトリックスのみを残し、細胞成分を除去することで同種移植が可能な材料となる。このように作製した材料は、人工材料の強度と、細胞外マトリックスによる高い生体適合性を持つ材料となると考えた。開発した材料を用いて補助人工心臓用脱血カニューレを作製し, VADと共にヤギに埋め込み、慢性実験を行った。実験期間中は、抗凝固療法、免疫抑制療法を行わなかった。実験終了後、カニューレと心筋はきれいに癒合しており、カニューレ内腔および外側に、問題とされている血栓は認められず、良好な結果を得た。&lt;/p&gt;

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

J-GLOBAL

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記述言語：英語   出版者・発行元：(一社)日本人工臓器学会  

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

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記述言語：日本語   出版者・発行元：(一社)ライフサポート学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：北海道外科学会  

J-GLOBAL

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記述言語：英語  

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記述言語：英語  

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記述言語：英語  

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記述言語：英語  

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記述言語：英語  

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記述言語：英語  

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記述言語：日本語   掲載種別：機関テクニカルレポート，技術報告書，プレプリント等   出版者・発行元：飯島藤十郎記念食品科学振興財団  

CiNii Books

J-GLOBAL

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記述言語：英語  

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記述言語：英語  

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記述言語：英語  

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記述言語：日本語   出版者・発行元：公益社団法人 日本生体医工学会  

In recently, PCPS and/or ECMO were got an opportunity to use in the field of critical care. But, these devices were so large to carry by hands and difficult to maneuver inexperienced worker. To solve the problems, we are developing a portable PCPS, called the Emergency Life Support System(ELSS). And the sequential flow pump (SFP) was designed for the build-in blood pump of the ELSS.<br>In this study, the optimal number of vanes for impeller in SFP was examined in two conditions using the computational fluid dynamics (CFD) analysis.First, the number of vanes was changed 6, 8 and 10 with constant vane pass volume. Second, the number of vanes was changed from 6 to 30 with constant priming volume in the impellers.<br>As results from CFD, in the first condition, the head pressure increased from 372mmHg to 408mmHg in proportion to the number of vanes. In the second condition, the peek head pressure was achieved in 12 vanes.

DOI： 10.11239/jsmbe.53.S197_01

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記述言語：日本語   出版者・発行元：公益社団法人 日本生体医工学会  

Heart-lung equipments are useful to save life of acute heart failure and respiratory distress patients. To realize a compact heart-lung equipment, the pump that generates high pressure with low flow is appropriate. To meet the purpose, we have been developing a novel centrifugal pump named sequential flow pump (SFP).The SFP has a structure that centrifugal force is given sequentially two times to the fluid with a single impeller. Since the SFP adopts single pivot or hydrodynamic bearing, axial balance of the impeller is essential. In this study, axial balance of the impeller was examined using computational fluid dynamics (CFD) analysis and actual models. In the experimental model, the impeller could be balanced up to 3200 rpm of rotational speed. However, stability was not so good.To improve the stability, a new model, in which basic simple straight-pass impeller could be balanced up to 1900 rpm of rotational speed, was developed. Various impellers were investigated in this pump. The results showed that the impeller having special shape in periphery would be excellent.

DOI： 10.11239/jsmbe.53.S197_02

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記述言語：日本語   出版者・発行元：公益社団法人 日本生体医工学会  

Hybrid material is new medical materials which have good strength derived from artificial materials and good biocompatibility derived from biotissue. Previous studies demonstrated that hybrid material had good biocompatibility. Under blood environment, it could also prevent thrombus formation without any antithrombotic therapy for more than 90 days. The purpose of this research is to establish a sterilization method of the hybrid material. The samples of hybrid material were obtained by implanting polyester velour inserted in a acrylic resin mold under the skin of goats.Then, they were freeze-dried. The sterilization methods were autoclave, dry heat, EOG, hydrogen peroxide gas plasma, and gamma beam sterilization. In addition, one sample was sterilized by gamma beam without freeze-drying. In total, six kinds of samples were tested.We observed physical shape and structural change using FE-SEM. Furthermore, we cultured vascular endothelial cell on the materials to investigate biocompatibility and cell adhesive property. Gamma beam sterilization without freeze-drying demonstrated the best result that vascular endothelial cell engrafted most on a sample.

DOI： 10.11239/jsmbe.53.S195_02

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語   出版者・発行元：Japan Soc. of Med. Electronics and Biol. Engineering  

The design requirements of the blood pump for implantable ventricular devices and total artificial heart are heavily affected by the anatomical limitation such as the intrathoracic space capacity and blood vessel layout. It is also necessary to modify the design of blood pumps for built-in use in the case of integrated pump lung system. Limitation occurs at the blood inflow position to the oxygenator whether the configuration of oxygenator was cylindrical or box shape. The design and structure of outflow port in the blood pump was decided according to the smoothness of the blood flow. Our research group tried to design the blood pumps specialized for built-in apparatus. In this study, we report a newly designed the multi-stage centrifugal pump named Sequential Flow Pump that two steps of pressurization is possible with one impeller.

DOI： 10.11239/jsmbe.52.OS-24

Scopus

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記述言語：日本語   出版者・発行元：北海道外科学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：公益社団法人 日本生体医工学会  

The problem is wedge thrombus due to material of cannula. We thought that to solve the problem replace its' material with hybrid material. Hybrid blood inflow cannula is formed by implanting the core which consist of polyester velour and titanium conduit. Then, the cell component decellularized. By using this cannula, examined on chronic animal experiment with VAD in heterologous transplantation to evaluate the biocompatibility of cannula. As a result, the goat survived 53days without antithrombogenic agents and the cannula was connected to neighboring cardiac muscle smoothly and thrombos weren't formed. And the result of immunostaining, surface of cannula was coated with endothelial cells.

DOI： 10.11239/jsmbe.52.O-243

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

J-GLOBAL

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記述言語：英語   出版者・発行元：(一社)日本人工臓器学会  

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記述言語：英語   出版者・発行元：(一社)日本人工臓器学会  

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記述言語：英語   出版者・発行元：(一社)日本人工臓器学会  

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

CiNii Books

CiNii Research

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：北海道外科学会  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語  

J-GLOBAL

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記述言語：日本語   出版者・発行元：北海道外科学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：北海道外科学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本人工臓器学会  

J-GLOBAL

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開催年月日： 2023年8月 - 2023年9月

記述言語：英語   会議種別：口頭発表（一般）  

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開催年月日： 2023年2月

記述言語：日本語   会議種別：口頭発表（一般）  

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開催年月日： 2022年11月

記述言語：日本語   会議種別：ポスター発表  

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開催年月日： 2022年11月

記述言語：英語   会議種別：口頭発表（一般）  

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開催年月日： 2022年2月

記述言語：英語   会議種別：口頭発表（一般）  

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開催年月日： 2022年2月

記述言語：日本語   会議種別：口頭発表（一般）  

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開催年月日： 2022年1月

記述言語：日本語   会議種別：口頭発表（一般）  

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開催年月日： 2021年11月

記述言語：日本語   会議種別：口頭発表（一般）  

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開催年月日： 2021年11月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：千葉県  

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開催年月日： 2021年11月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：千葉県  

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開催年月日： 2021年11月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：千葉県  

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開催年月日： 2021年10月 - 2021年11月

記述言語：日本語   会議種別：口頭発表（一般）  

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開催年月日： 2021年7月

記述言語：英語   会議種別：口頭発表（一般）  

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開催年月日： 2021年6月

記述言語：日本語   会議種別：口頭発表（一般）  

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開催年月日： 2021年2月

記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（公募）  

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開催年月日： 2021年2月

記述言語：日本語   会議種別：口頭発表（一般）  

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開催年月日： 2021年1月

記述言語：英語   会議種別：口頭発表（一般）  

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開催年月日： 2020年11月

記述言語：日本語   会議種別：口頭発表（一般）  

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開催年月日： 2020年11月

記述言語：日本語   会議種別：口頭発表（一般）  

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開催年月日： 2020年11月

記述言語：日本語   会議種別：口頭発表（一般）  

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開催年月日： 2020年11月

記述言語：日本語   会議種別：口頭発表（一般）  

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開催年月日： 2020年11月

記述言語：日本語   会議種別：口頭発表（一般）  

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開催年月日： 2020年11月

記述言語：日本語   会議種別：口頭発表（一般）  

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開催年月日： 2020年11月

記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（指名）  

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開催年月日： 2020年11月

記述言語：英語   会議種別：口頭発表（一般）  

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開催年月日： 2020年11月

記述言語：日本語   会議種別：口頭発表（一般）  

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開催年月日： 2020年9月

記述言語：日本語   会議種別：口頭発表（一般）  

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開催年月日： 2020年7月

記述言語：英語   会議種別：口頭発表（一般）  

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開催年月日： 2020年7月

記述言語：日本語   会議種別：口頭発表（一般）  

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開催年月日： 2020年5月

記述言語：日本語   会議種別：ポスター発表  

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開催年月日： 2020年5月

記述言語：日本語   会議種別：口頭発表（一般）  

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開催年月日： 2020年5月

記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（指名）  

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会議種別：口頭発表（一般）  

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出願人：国立大学法人東北大学, 国立大学法人旭川医科大学

出願番号：特願2022-46893  出願日：2022年3月

出願国：国内  

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出願人：国立大学法人旭川医科大学, バイオチューブ株式会社

出願番号：特願2022-040595  出願日：2022年3月

出願国：国内  

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出願人：国立大学法人東京工業大学, 国立大学法人東京医科歯科大学, 国立大学法人旭川医科大学

出願番号：特願2021-167592  出願日：2021年10月

出願国：国内  

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出願番号：2021-111590  出願日：2021年7月

出願国：国内  

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出願番号：2020-145958  出願日：2020年6月

出願国：国内  

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受賞区分：国内学会・会議・シンポジウム等の賞 

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受賞区分：国内学会・会議・シンポジウム等の賞 

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受賞区分：国内学会・会議・シンポジウム等の賞 

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受賞区分：国内学会・会議・シンポジウム等の賞 

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受賞区分：国内学会・会議・シンポジウム等の賞 

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受賞区分：国内外の国際的学術賞 

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受賞区分：国内学会・会議・シンポジウム等の賞 

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