2025/04/18 更新

写真a

オオクボ リョウ
大久保 諒
OOKUBO Ryou
所属
病院 診療科 外科(心臓大血管)
外部リンク

学歴

  • 旭川医科大学   医学部

    - 2017年3月

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    国名: 日本国

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経歴

  • 旭川医科大学   助教

    2023年4月 - 現在

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論文

  • A case of left main coronary artery to pulmonary fistula associated with vasospastic angina

    Kentaro Shirakura, Shougo Takahashi, Kaname Shimizu, Jun Maruoka, Yuki Setogawa, Ryo Okubo, Hiroyuki Miyamoto, Ryohei Ushioda, Daisuke Takeyoshi, Shingo Kunioka, Masahiro Tsutsui, Hiroyuki Kamiya

    Journal of Surgical Case Reports   2025年3月

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/jscr/rjaf173

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  • Successful surgical repair of a huge left ventricular pseudoaneurysm after repair of left ventricular rupture during mitral valve replacement

    Kyoka Hayashi, Ryohei Ushioda, Jun Maruoka, Kaname Shimizu, Kentaro Shirakura, Nobuhiro Mochizuki, Yuki Setogawa, Ryo Okubo, Miyamoto Hiroyuki, Shougo Takahashi, Shingo Kunioka, Masahiro Tsutsui, Kamiya Hiroyuki

    Journal of Surgical Case Reports   2024年10月

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/jscr/rjae636

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  • A case of minimum invasive debranch thoracic endovascular aortic repair for isolated left vertebral artery: complete revascularization without artificial vessels via a single small incision. 国際誌

    Masahiro Tsutsui, Kazuki Miyatani, Kentaro Shirakura, Yuki Setogawa, Fumitaka Suzuki, Hiroyuki Miyamoto, Ryo Okubo, Ryohei Ushioda, Shingo Kunioka, Natsuya Ishikawa, Norihumi Otani, Hiroyuki Kamiya

    Journal of surgical case reports   2024 ( 10 )   rjae595   2024年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Isolated left vertebral artery (ILVA) is one of the most frequent vertebral abnormalities. When performing thoracic endovascular aortic repair (TEVAR), the ILVA may have to be closed depending on the position of the stent graft; in these cases, the decision to reconstruct the ILVA depends on the state of cerebral blood flow. Here, we report a case of a 68-year-old male, in whom the Willis arterial circle was incomplete; we therefore performed a reconstructive method during zone 2-landing TEVAR that ensured ILVA and left subclavian artery blood flow without the use of artificial vessels. Only one supraclavicular incision was required for reconstruction. This method has some procedural difficulties; however, it does not use artificial blood vessels and can be performed with a single incision.

    DOI: 10.1093/jscr/rjae595

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  • Relationships among hemolysis indicators and neuron-specific-enolase in patients undergoing veno-arterial extracorporeal membrane oxygenation.

    Okubo R, Shirasaka T, Ushioda R, Narita M, Kunioka S, Kikuchi Y, Tsutsui M, Motoyoshi N, Kamiya H

    Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs   2024年7月

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    掲載種別:研究論文(学術雑誌)  

    Neuron-specific-enolase is used as a marker of neurological prognosis after cardiopulmonary resuscitation. It is also present in red blood cells and platelets. It is not known whether hemolysis increases the values of neuron-specific-enolase enough to clinically affect its interpretation in critically ill patients who are to be introduced to veno-arterial extracorporeal oxygenation. In this study, we examined the relationships among neuron-specific-enolase and hemolysis indicators such as free hemoglobin and lactate dehydrogenase after the introduction of veno-arterial extracorporeal oxygenation. Of the 91 patients who underwent veno-arterial extracorporeal membrane oxygenation in our hospital from January 1, 2018, to February 24, 2021, 68 patients survived for more than 24 h. Of these, 14 patients who were categorized into the better cerebral performance categories (1-3) and 19 patients who were categorized into the poor neurological prognosis category (4) were included. After the introduction of veno-arterial extracorporeal membrane oxygenation, neuron-specific-enolase was markedly higher in the poor neurological prognosis group than in the good neurological prognosis group (41.6 vs. 92.0, p = 0.04). A significant positive correlation was revealed between neuron-specific-enolase and free hemoglobin in the good neurological prognosis group (rs = 0.643, p = 0.0131). A similar relationship was observed for lactate dehydrogenase and neuron-specific-enolase in both the conscious (rs = 0.737, p = 0.00263) and non-conscious groups (rs = 0.544, p = 0.0176). When neuron-specific-enolase is used as a marker for neuroprognostic evaluation, an abnormally high value is likely to indicate the lack of consciousness, whereas a lower elevation should be interpreted with caution, taking into account the effects of hemolysis.

    DOI: 10.1007/s10047-024-01454-y

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  • Fulminant respiratory failure due to severe pneumothorax after re-do coronary artery bypass grafting treated with veno-venous extracorporeal membrane oxygenation. 国際誌

    Akito Inoue, Ryohei Ushioda, Kazuki Miyatani, Kentaro Shirakura, Nobuhiro Mochizuki, Hideki Isa, Yuki Setogawa, Masahiko Narita, Fumitaka Suzuki, Aina Hirofuji, Ryo Okubo, Shingo Kunioka, Masahiro Tsutsui, Kamiya Hiroyuki

    Journal of surgical case reports   2024 ( 5 )   rjae360   2024年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    This case report details the management of a 79-year-old man who developed massive postoperative pneumothorax following redo coronary artery bypass grafting due to severe lung adhesions. We successfully treated the patient using veno-venous extracorporeal membrane oxygenation without femoral cannulation, allowing for early rehabilitation initiation. Veno-venous extracorporeal membrane oxygenation is a reasonable option for cases of severe respiratory failure due to pneumothorax with lung destruction caused by re-sternotomy during re-do cardiac surgery.

    DOI: 10.1093/jscr/rjae360

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  • Renal rescue after inadvertent coverage during endovascular aneurysm repair

    Ryo Okubo, Norifumi Otani, Hiroyuki Kamiya

    Journal of Vascular Surgery Cases, Innovations and Techniques   2024年4月

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jvscit.2023.101411

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  • A case of non-bacterial thrombotic endocarditis on the aortic valve following coronary angiography. 国際誌

    Nobuhiro Motiduki, Ryohei Ushioda, Sayaka Yuzawa, Kazuki Miyatani, Hideki Isa, Yuki Setogawa, Kohei Ishidou, Masahiko Narita, Fumitaka Suzuki, Aina Hirofuji, Ryo Okubo, Shingo Kunioka, Masahiro Tsutsui, Natsuya Ishikawa, Kamiya Hiroyuki

    Journal of surgical case reports   2024 ( 4 )   rjae212   2024年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Nonbacterial thrombotic endocarditis (NBTE) on the aortic valve involves fibrin and platelet aggregate formation, potentially leading to embolic events. We present a case of NBTE on the aortic valve following coronary angiography (CAG) in a 54-year-old man with multiple comorbidities. Surgical thrombectomy was performed owing to acute cerebral infarcts. This case highlights the significance of considering that mechanical trauma from catheterization during CAG can trigger thrombus formation.

    DOI: 10.1093/jscr/rjae212

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  • Successful surgical correction of an incomplete atrioventricular septal defect in a 76-year-old female patient

    Kentaro Shirakura, Nobuyuki Akasaka, Daichi Mizushima, Masahiko Narita, Ryo Okubo, Tomoki Nakatsu, Daita Kobayashi, Hiroyuki Kamiya

    Journal of Surgical Case Reports   2024年3月

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/jscr/rjae187

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  • 気管切開後の重症僧帽弁閉鎖不全症に対し低侵襲心臓手術を行った一例

    井上 陽斗, 宮谷 和樹, 伊佐 秀貴, 鈴木 文隆, 瀬戸川 友紀, 大久保 諒, 広藤 愛菜, 國岡 信吾, 筒井 真博, 石川 成津矢, 紙谷 寛之

    北海道外科雑誌   69 ( 1 )   30 - 34   2024年

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    記述言語:日本語   出版者・発行元:北海道外科学会  

    気管切開術後の患者に対し,小切開低侵襲心臓手術(MICS ;Minimally invasive cardiac surgery)は創部感染予防の点から有効な治療法の一つである。症例は70代男性。僧帽弁閉鎖不全症に伴った急性心不全の診断にて,他院で加療中であった。心不全の増悪を認め,気管切開ののち当院循環器内科に紹介となった。当初はMitra Clipによる治療を行う予定であったが,入院後に39-40度の発熱が持続。感染性心内膜炎の可能性を否定できないため外科的治療の方針となった。MICSを用いた右小開胸下僧帽弁形成術が行われ、術後経過は良好であった。MICSを用いることで気管切開後の患者に対して低侵襲に外科的治療を行うことができ,創部感染の危険性を低減できる可能性が示唆された。

    DOI: 10.60440/hokkaidojsurg.69.1_30

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    その他リンク: https://ndlsearch.ndl.go.jp/books/R000000004-I033684816

  • Two-stage repair for DeBakey type II acute aortic dissection and distal aortic arch aneurysm in a nonagenarian patient

    Kentaro Shirakura, Shingo Kunioka, Kazuki Miyatani, Nobuhiro Mochizuki, Hideki Isa, Yuki Setogawa, Fumitaka Suzuki, Ryo Okubo, Ryohei Ushioda, Aina Hirofuji, Masahiro Tsutsui, Natsuya Ishikawa, Hiroyuki Kamiya

    Journal of Surgical Case Reports   2023年12月

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/jscr/rjad648

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  • Giant Superior Mesenteric Artery Aneurysm Treated by Endovascular Treatment in a Very Elderly Female

    Ryo Okubo, Shinsuke Kikuchi, Norifumi Otani, Masahiro Tsutsui, Hiroyuki Kamiya

    Vascular Specialist International   2023年5月

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.5758/vsi.230020

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  • Intra-Operative Occlusion of the Contralateral Common Iliac Artery by the Gore Excluder Iliac Branch System

    Ryo Okubo, Norifumi Otani, Masahiro Tsutsui, Hiroyuki Kamiya

    EJVES Vascular Forum   2023年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ejvsvf.2023.05.017

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  • Mesenteric Ischemia After Cardiac Surgery in Dialysis Patients: An Overlooked Risk Factor.

    Takeyoshi D, Shirasaka T, Shibagaki K, Okubo R, Kunioka S, Kikuchi Y, Kamiya H

    The heart surgery forum   2022年10月

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    掲載種別:研究論文(学術雑誌)  

    <h4>Background</h4>No study has examined the association of the calcification of abdominal artery orifices with nonocclusive mesenteric ischemia (NOMI) in dialysis patients undergoing cardiac surgery. Thus, this study aimed to determine whether calcification of abdominal blood vessel orifices in hemodialysis patients may be a risk factor for NOMI and examine the long-term survival of dialysis patients after undergoing cardiac surgery.<h4>Methods</h4>From April 2014 to September 2020, 100 dialysis patients underwent cardiac surgery at our hospital. The calcification of the celiac artery (CA) and superior mesenteric artery (SMA) was evaluated by computed tomography, and the degree of orifice stenosis was graded as follows: patent, 0; partial occlusion, 1; and complete occlusion, 2.<h4>Results</h4>Eight patients experienced NOMI, and all of them died. SMA calcification scores were not significantly different between the NOMI and non-NOMI groups (1.38±0.52 vs. 1.13±0.69; P = 0.247). However, the average CA orifice calcification score was significantly greater in the NOMI group than in the non-NOMI group (1.63±0.52 vs. 1.15±0.65; P = 0.039), and the SMA+CA orifice calcification scores were significantly different between the groups (3.00±0.76 vs. [non-NOMI] 2.25±1.18; P = 0.028). In all patients, the 30-day and in-hospital mortality rates were 13% and 18%, respectively. All patients were completely followed up with a mean follow-up period of 604±585 days. Kaplan-Meier survival curves showed that patients with SMA and CA calcification tended to have a shorter overall survival than patients without calcification; however, no significant difference was noted.<h4>Conclusions</h4>The calcification of CA and/or SMA orifices was associated with postoperative NOMI and poor long-term survival among dialysis patients undergoing cardiac surgery.

    DOI: 10.1532/hsf.4859

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  • Post-cardiotomy pericardial effusion and postoperative atrial fibrillation risk

    Yuta Kikuchi, Yasuaki Saijo, Masahiko Narita, Keisuke Shibagaki, Ryo Okubo, Shingo Kunioka, Tomonori Shirasaka, Hiroyuki Kamiya

    The International Journal of Cardiovascular Imaging   2022年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media {LLC}  

    DOI: 10.1007/s10554-022-02560-9

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  • A word of caution: bilateral axillofemoral bypass could not provide sufficient blood flow in a patient who underwent aortic resection for aortoesophageal fistula: a case report.

    Ryo Okubo

    Journal of surgical case reports   2021年10月

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    掲載種別:研究論文(学術雑誌)  

    An 81-year-old man was transferred to our hospital for a ruptured infected descending aortic aneurysm. An emergency thoracic endovascular aortic repair was performed, but a computed tomography scan 7 days later revealed an aortoesophageal fistula. The establishment of extracorporeal circulation using the femoral artery and utilization of the omentum was considered difficult. We performed bilateral axillofemoral bypass followed by descending aortic resection and esophagectomy. However, the patient's circulatory insufficiency worsened, and he died on the 18th postoperative day. In the treatment of aortoesophageal fistula, bilateral axillofemoral bypass is not recommended as an alternative to descending aortic replacement.

    DOI: 10.1093/jscr/rjab356

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  • A word of caution: bilateral axillofemoral bypass could not provide sufficient blood flow in a patient who underwent aortic resection for aortoesophageal fistula: a case report

    Ryo Okubo, Tomonori Shirasaka, Keisuke Shibagaki, Hiroyuki Kamiya

    Journal of Surgical Case Reports   2021 ( 10 )   2021年10月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Oxford University Press ({OUP})  

    DOI: 10.1093/jscr/rjab356

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  • Simultaneous aortic and pulmonary valve replacement in a young patient after intracardiac repair for tetralogy of Fallot: mechanical or biological valve? A case report.

    Ryo Okubo

    Journal of surgical case reports   2021年5月

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    掲載種別:研究論文(学術雑誌)  

    Pulmonary valve stenosis and regurgitation can occur in the distant stages after intracardiac repair of tetralogy of Fallot (TOF). Aortic regurgitation (AR) can also occur, although it is rare in postoperative patients. However, there are few reports of simultaneous replacement of the pulmonary and aortic valves in young patients after intracardiac repair of TOF, and there are no clear guidelines for selecting a valve prosthesis in such patients. We report a case of severe pulmonary valve stenosis and regurgitation with severe AR 38 years after the TOF operation, in which urgent double valve replacement and right ventricular outflow tract patching were performed with a mechanical valve in the aortic valve position and a bioprosthetic valve in the pulmonary valve position, with a successful outcome.

    DOI: 10.1093/jscr/rjab170

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  • Successful endovascular repair of a ruptured isolated iliac artery aneurysm: A case report.

    Fumiaki Kimura, Ryo Ookubo, Daita Kobayashi, Hideyuki Harada, Toshio Baba

    Clinical case reports   7 ( 10 )   1880 - 1884   2019年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Wiley-Blackwell Publishing Ltd  

    While isolated iliac artery aneurysm is rare, its rupture can lead to complete circulatory collapse and possibly death. Herein, we report a case of rupture of a large isolated aneurysm of the right common iliac artery that led to circulatory collapse and rapid endovascular repair saved the patient's life.

    DOI: 10.1002/ccr3.2385

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▼全件表示

MISC

講演・口頭発表等

  • 意図しないEVAR術中腎動脈閉塞の再建においてステントグラフトと大動脈の間でballoon catheterを拡張させ間隙を作ることで腎血流を担保しながらbail outに成功した1例

    大久保諒

    第6回北海道外科関連学会機構合同学術集会(HOPES 2023 

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    開催年月日: 2023年9月

    記述言語:日本語   会議種別:口頭発表(一般)  

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  • Two cases bailed out by using a steerable sheath for unintended renal artery occlusion during EVAR

    大久保 諒

    第53回日本心臓血管外科学会学術総会 

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    開催年月日: 2023年3月

    記述言語:英語   会議種別:口頭発表(一般)  

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