Organization
Hospital Clinical Departments Internal Medicine [Circulatory System, Kidney]
External link
AONUMA Tatsuya
Degree
-
博士課程 ( 2016.6 旭川医科大学 )
Education
-
Asahikawa Medical College Graduate School, Division of Medicine
- 2016.6
Country： Japan
Research History
-
Asahikawa Medical College Assistant Professor
2021.4
-
Asahikawa Medical College Visiting Assistant
2016.7 - 2021.3
-
Asahikawa Medical College Graduate student(doctorate program)
2012.4 - 2016.6
Studying abroad experiences
-
2019.4 - 2021.2 インディアナ大学医学部 ポスドク研究員
-
2017.4 - 2019.3 オーガスタ大学 ポスドク研究員
Papers
-
Periostin is a Pivotal Target of microRNA-150-5p in Cardiac Fibroblast Activation and Chronic Myocardial Infarction. International journal
Taiki Hayasaka, Bruno Moukette, Marisa N Sepúlveda, Satoshi Kawaguchi, Tatsuya Aonuma, Hamedane Moustapha, Lei Yang, Meena S Madhur, Suthat Liangpunsakul, Il-Man Kim
JACC. Basic to translational science 10 ( 8 ) 101330 - 101330 2025.7
-
Fatal Outcome Due to Pulmonary Arterial Intramural Hematoma Associated With Stanford Type A Acute Aortic Dissection: A Case Report. International journal
Yudai Shiwaku, Tatsuya Aonuma, Kanako Matsuda, Takahiro Shiokoshi, Naoki Nakagawa
Cureus 17 ( 6 ) e85969 2025.6
-
Cardiomyocyte-restricted MIAT deletion is sufficient to protect against murine myocardial infarction
Taiki Hayasaka, Satoshi Kawaguchi, Marisa N. Sepúlveda, Jian-peng Teoh, Bruno Moukette, Tatsuya Aonuma, Meena S. Madhur, Ankit A. Desai, Suthat Liangpunsakul, Simon J. Conway, Il-man Kim
Cell Death Discovery 11 ( 1 ) 2025.2
-
A case of rapid rupture of a calcified amorphous tumor observed by echocardiography. International journal
Kentaro Shirakura, Ryohei Ushioda, Masahiro Tsutsui, Shingo Kunioka, Nobuhiro Mochizuki, Tatsuya Aonuma, Naoko Kawabata, Erika Saitoh, Naoki Nakagawa, Hiroyuki Kamiya
Journal of surgical case reports 2025 ( 2 ) rjaf064 2025.2
-
MicroRNA-150 Deletion from Adult Myofibroblasts Augments Maladaptive Cardiac Remodeling Following Chronic Myocardial Infarction. International journal
Satoshi Kawaguchi, Marisa N Sepúlveda, Jian-Peng Teoh, Taiki Hayasaka, Bruno Moukette, Tatsuya Aonuma, Hyun Cheol Roh, Meena S Madhur, Il-Man Kim
Biomolecules 14 ( 12 ) 2024.12
-
Inducible deletion of microRNA activity in kidney mesenchymal cells exacerbates renal fibrosis
Hirofumi Sakuma, Keisuke Maruyama, Tatsuya Aonuma, Yuya Kobayashi, Taiki Hayasaka, Kohei Kano, Satoshi Kawaguchi, Kei Ichi Nakajima, Jun Ichi Kawabe, Naoyuki Hasebe, Naoki Nakagawa
Scientific Reports 14 ( 1 ) 2024.12
-
Severe mitral regurgitation in non-hypertrophic cardiomyopathy caused by systolic anterior motion of the mitral valve
Tatsuya Aonuma, Naoko Kawabata, Ayumi Date, Erika Saito, Kazumi Akasaka, Hiroyuki Kamiya, Naoki Nakagawa
Journal of Medical Ultrasonics 2024
-
SPRR1A is a key downstream effector of MiR-150 during both maladaptive cardiac remodeling in mice and human cardiac fibroblast activation
Satoshi Kawaguchi, Bruno Moukette, Marisa N. Sepúlveda, Taiki Hayasaka, Tatsuya Aonuma, Angela K. Haskell, Jessica Mah, Suthat Liangpunsakul, Yaoliang Tang, Simon J. Conway, Il man Kim
Cell Death and Disease 14 ( 7 ) 2023.7
-
Prostaglandin E<inf>2</inf> mediates the late phase of ischemic preconditioning in the heart via its receptor subtype EP<inf>4</inf>
Takayasu Kanno, Naoki Nakagawa, Tatsuya Aonuma, Jun ichi Kawabe, Koh ichi Yuhki, Naofumi Takehara, Naoyuki Hasebe, Fumitaka Ushikubi
Heart and Vessels 38 ( 4 ) 606 - 613 2023.4
-
MiR-150 blunts cardiac dysfunction in mice with cardiomyocyte loss of β<inf>1</inf>-adrenergic receptor/β-arrestin signaling and controls a unique transcriptome
Bruno Moukette, Satoshi Kawaguchi, Marisa N. Sepulveda, Taiki Hayasaka, Tatsuya Aonuma, Suthat Liangpunsakul, Lei Yang, Rohan Dharmakumar, Simon J. Conway, Il man Kim
Cell Death Discovery 8 ( 1 ) 2022.12
-
MiR-150 Attenuates Maladaptive Cardiac Remodeling Mediated by Long Noncoding RNA MIAT and Directly Represses Profibrotic Hoxa4
Tatsuya Aonuma, Bruno Moukette, Satoshi Kawaguchi, Nipuni P. Barupala, Marisa N. Sepúlveda, Kyle Frick, Yaoliang Tang, Maya Guglin, Subha V. Raman, Chenleng Cai, Suthat Liangpunsakul, Shinichi Nakagawa, Il Man Kim
Circulation: Heart Failure 15 ( 4 ) E008686 2022.4
-
Sarcopenia-derived exosomal micro-RNA 16-5p disturbs cardio-repair via a pro-apoptotic mechanism in myocardial infarction in mice
Taiki Hayasaka, Naofumi Takehara, Tatsuya Aonuma, Kohei Kano, Kiwamu Horiuchi, Naoki Nakagawa, Hiroki Tanaka, Jun ichi Kawabe, Naoyuki Hasebe
Scientific Reports 11 ( 1 ) 2021.12
-
Cardiomyocyte microRNA-150 confers cardiac protection and directly represses proapoptotic small proline–rich protein 1A
Tatsuya Aonuma, Bruno Moukette, Satoshi Kawaguchi, Nipuni P. Barupala, Marisa N. Sepúlveda, Christopher Corr, Yaoliang Tang, Suthat Liangpunsakul, R. Mark Payne, Monte S. Willis, Il Man Kim
JCI Insight 6 ( 18 ) 2021.9
-
Interactions between noncoding RNAs as epigenetic regulatory mechanisms in cardiovascular diseases
Bruno Moukette, Nipuni P. Barupala, Tatsuya Aonuma, Marisa Sepulveda, Satoshi Kawaguchi, Il man Kim
Methods in Cell Biology 166 309 - 348 2021.1
-
Capillary-resident EphA7<sup>+</sup> pericytes are multipotent cells with anti-ischemic effects through capillary formation
Yuri Yoshida, Maki Kabara, Kohei Kano, Kiwamu Horiuchi, Taiki Hayasaka, Yui Tomita, Naofumi Takehara, Akiho Minoshima, Tatsuya Aonuma, Keisuke Maruyama, Naoki Nakagawa, Nobuyoshi Azuma, Naoyuki Hasebe, Jun ichi Kawabe
Stem Cells Translational Medicine 9 ( 1 ) 120 - 130 2020.1
-
The antioxidant and DNA-repair enzyme apurinic/apyrimidinic endonuclease 1 limits the development of tubulointerstitial fibrosis partly by modulating the immune system
Keisuke Maruyama, Naoki Nakagawa, Tatsuya Aonuma, Yukihiro Saito, Taiki Hayasaka, Kohei Kano, Kiwamu Horiuchi, Naofumi Takehara, Jun ichi Kawabe, Naoyuki Hasebe
Scientific Reports 9 ( 1 ) 2019.12
-
Circular noncoding RNAs as potential therapies and circulating biomarkers for cardiovascular diseases review-article
Ahmed S. Bayoumi, Tatsuya Aonuma, Jian Peng Teoh, Yao Liang Tang, Il Man Kim
Acta Pharmacologica Sinica 39 ( 7 ) 1100 - 1109 2018.7
-
β-arrestin-biased agonism of β-adrenergic receptor regulates Dicer-mediated microRNA maturation to promote cardioprotective signaling
Jian Peng Teoh, Ahmed S. Bayoumi, Tatsuya Aonuma, Yanyan Xu, John A. Johnson, Huabo Su, Neal L. Weintraub, Yaoliang Tang, Il Man Kim
Journal of Molecular and Cellular Cardiology 118 225 - 236 2018.5
-
A circular RNA regulator quaking: a novel gold mine to be unfolded in doxorubicin-mediated cardiotoxicity
Tatsuya Aonuma, Ahmed S. Bayoumi, Yaoliang Tang, Il Man Kim
Non-Coding RNA Investigation 2 2018.4
-
A carvedilol-responsive microRNA, miR-125b-5p protects the heart from acute myocardial infarction by repressing pro-apoptotic bak1 and klf13 in cardiomyocytes
Ahmed S. Bayoumi, Kyoung mi Park, Yongchao Wang, Jian peng Teoh, Tatsuya Aonuma, Yaoliang Tang, Huabo Su, Neal L. Weintraub, Il man Kim
Journal of Molecular and Cellular Cardiology 114 72 - 82 2018.1
-
Pericyte-specific ninjurin1 deletion attenuates vessel maturation and blood flow recovery in hind limb ischemia
Akiho Minoshima, Maki Kabara, Motoki Matsuki, Yuri Yoshida, Kohei Kano, Yui Tomita, Taiki Hayasaka, Kiwamu Horiuchi, Yukihiro Saito, Tatsuya Aonuma, Masato Nishimura, Keisuke Maruyama, Naoki Nakagawa, Jun Sawada, Naofumi Takehara, Naoyuki Hasebe, Jun Ichi Kawabe
Arteriosclerosis, Thrombosis, and Vascular Biology 38 ( 10 ) 2358 - 2370 2018
-
MicroRNA-532 protects the heart in acute myocardial infarction, and represses prss23, a positive regulator of endothelial-to-mesenchymal transition
Ahmed S. Bayoumi, Jian Peng Teoh, Tatsuya Aonuma, Zhize Yuan, Xiaofen Ruan, Yaoliang Tang, Huabo Su, Neal L. Weintraub, Il Man Kim
Cardiovascular Research 113 ( 13 ) 1603 - 1614 2017.11
-
Apoptosis-resistant cardiac progenitor cells modified with apurinic/apyrimidinic endonuclease/ redox factor 1 gene overexpression regulate cardiac repair after myocardial infarction
Tatsuya Aonuma, Naofumi Takehara, Keisuke Maruyama, Maki Kabara, Motoki Matsuki, Atsushi Yamauchi, Jun Ichi Kawabe, Naoyuki Hasebe
Stem Cells Translational Medicine 5 ( 8 ) 1067 - 1078 2016.8
-
Adult accessory mitral valve with septal hypertrophy
Tatsuya Aonuma, Naofumi Takehara, Erika Saito, Naoyuki Hasebe
Internal Medicine 55 ( 17 ) 2515 2016
-
Ninjurin1 is a novel factor to regulate angiogenesis through the function of pericytes
Motoki Matsuki, Maki Kabara, Yukihiro Saito, Kohei Shimamura, Akiho Minoshima, Masato Nishimura, Tatsuya Aonuma, Naofumi Takehara, Naoyuki Hasebe, Jun Ichi Kawabe
Circulation Journal 79 ( 6 ) 1363 - 1371 2015.5
-
Association between microalbuminuria predicting in-stent restenosis after myocardial infarction and cellular senescence of endothelial progenitor cells
Hisanobu Ota, Naofumi Takehara, Tatsuya Aonuma, Maki Kabara, Motoki Matsuki, Atsushi Yamauchi, Toshiharu Takeuchi, Jun Ichi Kawabe, Naoyuki Hasebe
PLoS ONE 10 ( 4 ) 2015.4
-
Immortalized multipotent pericytes derived from the vasa vasorum in the injured vasculature. A cellular tool for studies of vascular remodeling and regeneration
Maki Kabara, Jun Ichi Kawabe, Motoki Matsuki, Yoshiki Hira, Akiho Minoshima, Kohei Shimamura, Atsushi Yamauchi, Tatsuya Aonuma, Masato Nishimura, Yukihiro Saito, Naofumi Takehara, Naoyuki Hasebe
Laboratory Investigation 94 ( 12 ) 1340 - 1354 2014.12
-
Nerve growth factor stimulates regeneration of perivascular nerve, and induces the maturation of microvessels around the injured artery
Akira Asanome, Jun ichi Kawabe, Motoki Matsuki, Maki Kabara, Yoshiki Hira, Hiroki Bochimoto, Atsushi Yamauchi, Tatsuya Aonuma, Naofumi Takehara, Tsuyoshi Watanabe, Naoyuki Hasebe
Biochemical and Biophysical Research Communications 443 ( 1 ) 150 - 155 2014.1
-
Apurinic/apyrimidinic endonucelase 1 maintains adhesion of endothelial progenitor cells and reduces neointima formation
Atsushi Yamauchi, Jun Ichi Kawabe, Maki Kabara, Motoki Matsuki, Akira Asanome, Tatsuya Aonuma, Hisanobu Ohta, Naofumi Takehara, Taku Kitagawa, Naoyuki Hasebe
American Journal of Physiology - Heart and Circulatory Physiology 305 ( 8 ) 2013.10
Research Projects
-
抗HER２薬関連心毒性にける新規バイオマーカーlong noncoding RNAの探索
2024.4 - 2025.3
民間財団等
-
乳癌患者におけるトラスツズマブ関連心毒性の新規バイオマーカーlncRNAの探索
Grant number：22K16060 2022.4 - 2025.3
日本学術振興会 科学研究費助成事業 若手研究
青沼 達也
Grant amount：\4,680,000 （ Direct Cost: \3,600,000 、 Indirect Cost：\1,080,000 ）
アントラサイクリン系抗がん剤としてエピルビシンの治療を受けた後にトラスツズマブ(Trastuzumab：TZB)治療を受けた乳がん患者を対象として症例登録をしているが、本症例の登録基準を満たす患者は半年強で6名と研究開始時の予想を大きく下回った。しかし、少ない症例登録者の中でもアントラサイクリン治療終了時には心臓超音波検査で測定した左室駆出率は59%と左室収縮能が保持されていたが、TZB治療後に左室駆出率が43%まで低下したTZB関連心毒性(+)症例が確認された。同症例ではTZB治療終了時は採血でのトロポニンTやNT-proBNPといった心筋障害や心不全のバイオマーカーの異常はなかったが、TZB関連心毒性(+)としてTZBの一時中断と心保護薬を開始して左室駆出率は改善している。各症例で回収した血漿サンプルは-80℃で保存しており、適宜RNAを抽出して後のlong noncoding RNAアレイ解析に用いる予定である。
<BR>
ヒト培養心筋細胞株は当初予定していたAC-16 Human cardiomyocyteではなく、Promo cell社のHuman cardiac myocyte（HCM）を用いて心筋細胞のTZB心毒性を評価する系を構築している。HCMにドキソルビシン（Doxorubicin：DOX）を5-10μMで4時間、次いでTZBを1-10 μMで20時間を投与する系でTUNEL法による細胞のアポトーシス誘導、細胞内ROS産生をそれぞれ評価した。DOXによってHCMのアポトーシス陽性細胞数、細胞内ROSが有意に増加することが確認されたが、DOX後にTZBを投与してアポトーシス陽性細胞、細胞内ROSをDOX単剤より増加させる実験系は未だに確立できていない。反復回数が少なく有意差は示されていないが、定量PCRによる解析ではDOXによる心毒性で上昇すると報告されているlong nocoding RNA MHRTはTZBを投与したHCMで上昇する可能性が示唆された。 -
Diabetic Circulatory Disorder
Grant number：22K08301 2022.4 - 2025.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Grant amount：\4,160,000 （ Direct Cost: \3,200,000 、 Indirect Cost：\960,000 ）
-
トラスツズマブ関連心毒性におけるlong noncoding RNAの役割に関する検討 英文題目名
2021.11
民間財団等
-
Establishment and functional analysis of IGF-2 positive iPSC-derived cardiac progenitor cells as a novel tool for cardiac cell transplantation
Grant number：17K15981 2017.4 - 2022.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
Aonuma Tatsuya
Grant amount：\4,030,000 （ Direct Cost: \3,100,000 、 Indirect Cost：\930,000 ）
The aim of this research is to establish iPSC-derived cardiac progenitor cells which have superior capability of cardiac differentiation and to assess therapeutic effect of the iPSC-derived cells by transplanting into mouse myocardial infarction models. Based on our preliminary data that cardiac progenitor cells-derived iPSC which have high superior capability of cardiac differentiation had higher expression levels of IGF-2, we purified IGF-2 positive cells from cardiac differentiated iPSCs. We demonstrated that purified iPSC-derived IGF-2 positive cells have superior capability of cardiac differentiation. We established the method for expanding cell culture of the IGF-2 positive cardiac progenitor cells.