Updated on 2026/03/11

写真a

 
NOZAKI Hiroyoshi
 
Organization
School of Medicine Medical Course Clinical Medicine Dermatology
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Committee Memberships

  • PIONEERS®GPP   Content Creation Committee member  

    2024.9   

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    Committee type：Other

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Papers

  • Synergistic activation of STING and CD40 in the tumor microenvironment enhances CD8+ T-cell-dependent antitumor immunity

    Nanami Ujiie, Akemi Kosaka, Shunsuke Yasuda, Ryusei Yoshino, Takahiro Inoue, Hiroyoshi Nozaki, Toshihiro Nagato, Masahiro Kitada, Takayuki Ohkuri, Hiroya Kobayashi

    Biochemical and Biophysical Research Communications   792   152995 - 152995   2025.12

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    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.bbrc.2025.152995

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  • Serum Anti-Drug Antibodies in Psoriasis Patients Undergoing Biologic Therapy in Real-World Clinical Practice: A Single-Center Retrospective Study. Reviewed International journal

    Hiroyoshi Nozaki, Masaru Honma, Mari Kishibe, Yasuyuki Fujita

    The Journal of dermatology   52 ( 10 )   1598 - 1602   2025.10

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    Biologics are essential for treating psoriasis; however, secondary failure, often due to the development of anti-drug antibodies, is a significant concern. This study aimed to evaluate the relationship between secondary failure and the production of anti-drug antibodies in a real-world setting. Serum levels of anti-adalimumab and anti-secukinumab antibodies were measured using a commercial enzyme-linked immunosorbent assay (ELISA) kit. A retrospective analysis was conducted on 85 patients with psoriasis, focusing on cases in which dermatologists identified secondary failure during biologic therapy. In the adalimumab group, eight patients were identified as having secondary failure. Among them, two showed high titers of anti-drug antibodies, and one showed a low titer. In the secukinumab group, four cases were judged to have secondary failure, but none had elevated antibody titers. The results of this study indicate that the mechanisms underlying secondary failure in real-world settings may vary depending on the drug. The secondary failure of adalimumab, a drug with high immunogenicity, is primarily attributed to the production of anti-drug antibodies. In contrast, for secukinumab, which has low immunogenicity, extending the dosing interval may lead to reduced serum drug levels and an increased risk of secondary failure.

    DOI： 10.1111/1346-8138.17894

    PubMed

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  • Malignant Transformation From Seborrheic Keratosis to Squamous Cell Carcinoma Is More Likely to Occur in Nonexposed Areas: A Single‐Center Retrospective Study Reviewed

    Hiroyoshi Nozaki, Akemi Ishida‐Yamamoto, Tomoe Nakagawa, Kaori Umekage, Kyoko Kanno, Masaru Honma, Mari Kishibe

    The Journal of Dermatology   52 ( 7 )   2025.4

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    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    DOI： 10.1111/1346-8138.17756

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  • Toxic epidermal necrolysis induced by nivolumab therapy for unresectable intraperitoneal cancer Reviewed

    Hiroyoshi Nozaki, Jiro Uehara, Naoki Kato, Masaru Honma, Akemi Ishida-Yamamoto

    Journal of Cutaneous Immunology and Allergy   7   2025.1

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Frontiers Media SA  

    DOI： 10.3389/jcia.2024.14014

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  • Cheilitis granulomatosa successfully treated by ustekinumab Reviewed

    Masaru Honma, Hiroyoshi Nozaki

    The Journal of Dermatology   52 ( 4 )   2024.11

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    Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    DOI： 10.1111/1346-8138.17555

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  • Potential thioflavin T false positives in lipomembranous changes in adipocytes during systemic amyloidosis diagnosis Reviewed

    Mari Kishibe, Kaori Umekage, Hiroyoshi Nozaki, Tomoe Nakagawa, Kyoko Kanno, Akira Manabe, Akemi Ishida‐Yamamoto

    The Journal of Dermatology   52 ( 1 )   171 - 174   2024.9

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    Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    Abstract

    The diagnosis of systemic amyloidosis relies on the detection of amyloid deposition in the tissue, often utilizing biopsy specimens from the abdominal skin owing to their minimal invasiveness. Several amyloid staining methods, including Congo Red, Direct Fast Scarlet (DFS), and Thioflavin T (ThT), have been employed for visualization. Lipomembranous fat necrosis (LFN) is a non‐specific reaction pattern of adipose tissue to injury, typically derived from blood insufficiency across a wide range of clinical conditions or diseases. It is characterized by the presence of eosinophilic, crenulated, and/or serpiginous membranes in fat lobules. We encountered a patient in whom ThT yielded suspiciously positive results in amyloidosis screening tests. Furthermore, our retrospective observations suggested that ThT staining was positive for LFN, whereas DFS and Congo red staining yielded negative results. The awareness that LFN can result in false‐positive ThT staining during amyloid screening is crucial to avoiding the misdiagnosis of systemic amyloidosis. Furthermore, skin samples should not be collected from areas prone to developing lipomembranous changes. The use of more than two different stains for skin biopsy specimens is recommended.

    DOI： 10.1111/1346-8138.17476

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  • Clinical Characteristics of Psoriasis Cases Treated by Biologics With an Extended Administration Interval: A Single-Center, Retrospective Observational Study Reviewed

    Hiroyoshi Nozaki, Masaru Honma, Akemi Ishida-Yamamoto

    Cureus   16 ( 5 )   e59969   2024.5

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    DOI： 10.7759/cureus.59969

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  • 旭川医科大学皮膚科でエリテマトーデスに対してヒドロキシクロロキンを導入した30症例のまとめ Reviewed

    野崎 尋意, 岸部 麻里, 菅野 恭子, 井川 哲子, 本間 大, 中馬 真幸, 田崎 嘉一, 山本 明美

    日本皮膚科学会雑誌   134 ( 4 )   733 - 741   2024.4

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    Authorship：Lead author   Language：Japanese  

    DOI： 10.14924/dermatol.134.733

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  • Characteristics of osteonecrosis of the femoral head complicated by psoriasis Reviewed

    Hiroyoshi Nozaki, Masaru Honma, Hiromasa Tanino, Akemi Ishida‐Yamamoto

    The Journal of Dermatology   51 ( 2 )   e42 - e43   2023.9

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    DOI： 10.1111/1346-8138.16959

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  • 特発性大腿骨頭壊死を生じた乾癬性紅皮症の1例 Reviewed

    野崎 尋意, 本間 大, 林 圭, 山本 明美, 谷野 弘昌

    皮膚科の臨床   64 ( 8 )   1322 - 1323   2022.7

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    Authorship：Lead author   Language：Japanese  

    DOI： 10.18888/hi.0000003419

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  • ヒトパルボウイルスB19感染を契機にIgA血管炎を発症し,顕在化した全身性エリテマトーデス Invited

    野崎 尋意, 小松成綱, 橋本 喜夫, 松尾 忍, 小川 弥生, 山本 明美

    皮膚病診療   44 ( 2 )   120 - 124   2022.2

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    Authorship：Lead author   Language：Japanese  

    DOI： 10.24733/pd.0000002830

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Awards

  • 鳥居・帝國乾癬研究奨励賞（学会発表部門）

    2021.9   日本乾癬学会   掌蹠膿疱症の治療中に汎発型膿疱性乾癬を発症し、水疱性類天疱瘡を合併した 1 例

    野崎 尋意, 小松 成綱, 芝木 光, 武市 拓也, 石井 文人, 秋山 真志, 橋本 喜夫, 本間 大, 山本 明美

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