Updated on 2026/04/11

写真a

 
HATAYAMA Mayumi
 
Organization
School of Medicine Medical Course Clinical Medicine Internal Medicine Division of Blood
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Papers

  • A Case of Successful Treatment of Aplastic Anemia Induced by Immune Checkpoint Inhibitors for Lung Cancer.

    Chihiro Sumi, Masayo Yamamoto, Rena Sasaki, Takuya Funayama, Takeshi Saito, Mayumi Hatayama, Motohiro Shindo, Yasuhiro Umekage, Takaaki Sasaki, Sayaka Yuzawa, Mishie Tanino, Shuichiro Takahashi

    Internal medicine (Tokyo, Japan)   2025.7

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    Immune checkpoint inhibitors (ICIs) are effective against many types of cancers. However, these drugs can trigger unintended immune attacks on normal tissues, leading to a range of side effects known as immune-related adverse events (irAEs). Involvement of the hematopoietic system in irAEs is rare, and a standard treatment has not yet been established. We herein report a 72-year-old man with non-small-cell lung cancer who developed aplastic anemia (AA) after ICI treatment. Eltrombopag improved the long-term blood count without causing severe infection. This case suggests that eltrombopag may be a viable treatment option for ICI-induced AA.

    DOI： 10.2169/internalmedicine.5590-25

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  • Brain AMPK signaling improves intestinal barrier function through brain orexin and the vagal pathway in rats

    Takuya Funayama, Tsukasa Nozu, Masatomo Ishioh, Chihiro Sumi, Takeshi Saito, Mayumi Hatayama, Masayo Yamamoto, Motohiro Shindo, Shuichiro Takahashi, Toshikatsu Okumura

    Neuroscience Letters   854   138208 - 138208   2025.4

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    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.neulet.2025.138208

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  • Monitoring SARS-CoV-2 Viral Load and CD4+ T-cell Count After ART in a Patient Diagnosed With AIDS Following SARS-CoV-2 Infection: A Case Report. International journal

    Yasuhiro Umekage, Mayumi Hatayama, Akari Yagita, Kiichi Nitanai, Hiraku Yanada, Ryota Shigaki, Yoshinori Minami, Takaaki Sasaki

    Cureus   15 ( 12 )   e51189   2023.12

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    We describe the case of a 36-year-old man diagnosed with human immunodeficiency virus (HIV) following prolonged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia. The patient had a complication of pneumocystis pneumonia. Upon initiating highly active antiretroviral therapy, we monitored HIV RNA levels, CD4+ T-cell count, SARS-CoV-2 viral load, and IgG antibodies against SARS-CoV-2. At 167 days post SARS-CoV-2 diagnosis, the patient's CD4+ T-cell count increased to 180 cells/μL. IgG antibodies against SARS-CoV-2 were undetectable despite a decreased SARS-CoV-2 viral load. HIV screening is necessary in cases of prolonged SARS-CoV-2 pneumonia or persistent SARS-CoV-2 shedding. When diagnosed with HIV infection, it is advisable to consider the possibility of pneumocystis pneumonia.

    DOI： 10.7759/cureus.51189

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  • Monitoring mutant KRAS in plasma cell-free DNA can predict disease progression in a patient with multiple myeloma: A case report. International journal

    Masayo Yamamoto, Motohiro Shindo, Takuya Funayama, Chihiro Sumi, Takeshi Saito, Yasumichi Toki, Mayumi Hatayama, Yusuke Ono, Kazuya Sato, Yusuke Mizukami, Toshikatsu Okumura

    Clinica chimica acta; international journal of clinical chemistry   551   117590 - 117590   2023.11

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    BACKGROUND AND AIMS: Multiple myeloma (MM), a neoplasm of plasma cells (PCs), is a highly heterogeneous disease with multifocal dissemination throughout the body. Minimal residual disease (MRD) detected using PCs in bone marrow (BM) is important for MM management; however, frequent invasive examinations impose a significant burden on patients. METHODS: Analysis using plasma cell-free DNA (cfDNA) might represent an alternative tool for disease monitoring. In this study, we observed the disease status in a patient with MM by examining the KRAS mutation allele frequency (MAF) in plasma cfDNA using digital PCR. RESULTS: During treatment, the MAF was correlated with serum immunoglobulin A and free light chain-kappa levels. After the second autologous peripheral blood stem cell transplantation, the KRAS MAF became immediately positive after confirming MRD negativity using PCs from BM. Shortly thereafter, the patient experienced clinical relapse primarily involving bone lesions. CONCLUSION: Mutant KRAS monitoring in cfDNA using serial blood collection might reflect the disease status more accurately than invasive BM examinations, especially in patients with MM whose primary lesions have extra-BM locations. It could also help predict treatment responses and outcomes.

    DOI： 10.1016/j.cca.2023.117590

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  • [Successful rituximab treatment of TAFRO syndrome refractory to glucocorticoids and tocilizumab].

    Chihiro Sumi, Yasumichi Toki, Takuya Funayama, Takeshi Saito, Mayumi Hatayama, Masayo Yamamoto, Motohiro Shindo, Sayaka Yuzawa, Mishie Tanino, Toshikatsu Okumura

    [Rinsho ketsueki] The Japanese journal of clinical hematology   64 ( 4 )   265 - 270   2023

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    A 53-year-old man was presented with fever, eyelid edema, and thrombocytopenia. Based on examination outcomes, he was diagnosed with immune thrombocytopenia. He was prescribed prednisolone (PSL) at 0.5 mg/kg/day; subsequently, his platelet count improved and fever improved. PSL dose was tapered and stopped without relapse. However, 1 month later, the patient presented to our hospital with fever, generalized edema, thrombocytopenia, and acute renal failure. Computed tomography revealed multiple lymphadenopathies, hepatomegaly, pleural effusion, and ascites. Bone marrow biopsy indicated reticulin fibrosis, and lymph node biopsy revealed mixed-type Castleman disease. Based on these findings, he was diagnosed with grade 5 TAFRO syndrome (very severe). Steroid pulse therapy and tocilizumab were ineffective in improving his condition. Therefore, rituximab was administered instead of tocilizumab, and his condition eventually improved. The optimal treatment for TAFRO syndrome is yet to be established. If tocilizumab is ineffective as the second-line treatment, then rituximab might be effective.

    DOI： 10.11406/rinketsu.64.265

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  • Late-onset posttransplant Epstein-Barr virusrelated lymphoproliferative disease after cord blood transplantation for chronic active Epstein Barr virus infection: A case report. International journal

    Masayo Yamamoto, Motohiro Shindo, Takuya Funayama, Chihiro Sumi, Takeshi Saito, Yasumichi Toki, Mayumi Hatayama, Ken-Ichi Imadome, Yusuke Mizukami, Toshikatsu Okumura

    Medicine   101 ( 12 )   e29055   2022.3

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    INTRODUCTION: Posttransplant lymphoproliferative disease (PTLD) is a critical complication of hematopoietic stem cell transplantation (HSCT). PTLD is classified into early and late-onset PTLDs. In post-HSCT patients, late-onset PTLD is rare, particularly PTLD after HSCT for Epstein-Barr virus (EBV)-related lymphoproliferative disease. Here, we report the case of a patient diagnosed with late-onset EBV-related hemophagocytic lymphohistiocytosis (HLH), that of PTLD, after HSCT for chronic active EBV infection (CAEBV), that of EBV related lymphoproliferative disease, probably because of EBV reactivation. PATIENT CONCERNS AND DIAGNOSIS: A 22-year-old woman with abdominal fullness visited our hospital. Blood examination showed pancytopenia with atypical lymphocytes, liver dysfunction, and elevated lactate dehydrogenase level. In contrast, bone marrow aspiration showed slight hemophagocytosis with increased natural-killer cells (NK cells). As serum antibodies against EBV were atypical, we calculated the EBV-DNA level in peripheral blood and this level was significantly high. EBV was infected with NK cells, and EBV's monoclonality in NK cells was confirmed. Thus, the patient was diagnosed with CAEBV. INTERVENTIONS AND OUTCOMES: The patient received chemotherapy and cord blood cell transplantation (CBT); CAEBV was well controlled. Approximately 6years from CBT for CAEBV, she visited our hospital because of fever. Blood examination revealed pancytopenia with atypical lymphocytes, liver dysfunction, and elevated lactate dehydrogenase level. In contrast, bone marrow aspiration showed hemophagocytosis with increased B and T cell counts without increased NK cell count. Additionally, serum antibody titers against EBV were atypical, and the EBV-DNA level in the peripheral blood was high. EBV was infected with only B cells, and EBV's monoclonality was confirmed. A more detailed analysis indicated that EBV-specific cytotoxic T lymphocytes were inactive. Therefore, she was diagnosed with late-onset EBV-related HLH. She received extensive treatment, but EBV-related HLH did not improve. Finally, she died about 3 weeks after diagnosis. CONCLUSION: PTLD, including HLH, is a life-threatening complication after transplantation, including HSCT. To our knowledge, this is the first case of late-onset EBV-related HLH after CBT for CAEBV. Late-onset PTLD has an indolent clinical course, but our patient's disease course was extremely aggressive. Therefore, late-onset EBV-related PTLD may be life-threatening.

    DOI： 10.1097/MD.0000000000029055

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  • Acquired hemophilia A associated with Epstein-Barr-virus-associated T/natural killer-cell lymphoproliferative disease: A case report. International journal

    Masayo Yamamoto, Motohiro Shindo, Chihiro Sumi, Sho Igarashi, Takeshi Saito, Nodoka Tsukada, Yasumichi Toki, Mayumi Hatayama, Junki Inamura, Kazuya Sato, Yusuke Mizukami, Yoshihiro Torimoto, Toshikatsu Okumura

    Medicine   100 ( 16 )   e25518   2021.4

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    INTRODUCTION: Acquired hemophilia A (AHA) is a rare bleeding disorder caused by autoantibodies against factor VIII (FVIII). Hematological malignancies, especially lymphoid malignancies, are known to be underlying causes of AHA; however, thus far, there is no report of AHA associated with Epstein-Barr-virus-associated T/natural killer-cell lymphoproliferative disease (EBV-T/NK-LPD). Here, we present a case of AHA that developed during treatment for EBV-T/NK-LPD. HISTORY: A 69-year-old man visited our hospital because of general fatigue. Blood examination showed pancytopenia, and computed tomography revealed whole-body lymphadenopathy, but there were no findings indicating hematological malignancy from bone marrow aspiration and cervical lymph node biopsy. The level of EBV DNA in peripheral blood was extremely high, and he was diagnosed with EBV-T/NK-LPD. EBV-T/NK-LPD improved with prednisolone (PSL) administration. Seventeen months after starting treatment, the patient complained of back and right leg pain. At that time, he had been treated with low-dose PSL, and EBV-T/NK-LPD was well controlled. Imaging revealed hematoma of the right iliopsoas muscle. Prolonged activated partial thromboplastin time (APTT) was the only abnormal finding in a screening coagulation test. FVIII coagulant activity was below detection limit, and FVIII inhibitor level was increased. From these results, he was diagnosed with AHA.A higher dose of PSL was administered, and, after 1 month of treatment, FVIII activity gradually increased, and FVIII inhibitor level became undetectable. APTT also normalized, and complete remission was achieved and maintained for 13 months with low-dose PSL. During treatment, EBV-T/NK-LPD was well controlled. CONCLUSION: It is speculated that proliferating lymphocytes interfere with normal immune functions and that abnormal autoantibodies are produced from those lymphocytes in patients with LPD. Therefore, we speculate that EBV-infected and proliferating monoclonal NK cells might have modulated the immune system and produced autoantibodies against FVIII, thus causing AHA in this patient with EBV-T/NK-LPD.

    DOI： 10.1097/MD.0000000000025518

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  • Pseudogout Attack after Pegfilgrastim Administration in Anaplastic Large Cell Lymphoma.

    Mayumi Hatayama, Katsuya Ikuta, Masatomo Ishioh, Takeshi Saito, Yasumichi Toki, Masayo Yamamoto, Motohiro Shindo, Yoshihiro Torimoto, Toshikatsu Okumura

    Internal medicine (Tokyo, Japan)   57 ( 12 )   1779 - 1782   2018.6

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    A 67-year-old man with relapsed anaplastic large cell lymphoma received salvage chemotherapy, and pegfilgrastim was used to prevent febrile neutropenia. On day 18 of chemotherapy, he developed a pseudogout attack. Although the first symptoms improved, another pseudogout attack occurred when he received the second course of chemotherapy and pegfilgrastim. Filgrastim was then used for the third course of chemotherapy, and a pseudogout attack did not occur. The serum granulocyte-stimulating factor (G-CSF) level was extremely elevated only when pegfilgrastim was used, suggesting a relationship between pseudogout and G-CSF. Pseudogout should be recognized as an adverse effect of pegfilgrastim.

    DOI： 10.2169/internalmedicine.9362-17

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  • Reticulocyte hemoglobin equivalent as a potential marker for diagnosis of iron deficiency Reviewed

    Yasumichi Toki, Katsuya Ikuta, Yoshie Kawahara, Noriyasu Niizeki, Masayuki Kon, Motoki Enomoto, Yuko Tada, Mayumi Hatayama, Masayo Yamamoto, Satoshi Ito, Motohiro Shindo, Yoko Kikuchi, Mitsutaka Inoue, Kazuya Sato, Mikihiro Fujiya, Toshikatsu Okumura

    INTERNATIONAL JOURNAL OF HEMATOLOGY   106 ( 1 )   116 - 125   2017.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s12185-017-2212-6

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  • Iron-induced epigenetic abnormalities of mouse bone marrow through aberrant activation of aconitase and isocitrate dehydrogenase Reviewed

    Masayo Yamamoto, Hiroki Tanaka, Yasumichi Toki, Mayumi Hatayama, Satoshi Ito, Lynda Addo, Motohiro Shindo, Katsunori Sasaki, Katsuya Ikuta, Takaaki Ohtake, Mikihiro Fujiya, Yoshihiro Torimoto, Yutaka Kohgo

    INTERNATIONAL JOURNAL OF HEMATOLOGY   104 ( 4 )   491 - 501   2016.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s12185-016-2054-7

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  • A selective splicing variant of hepcidin mRNA in hepatocellular carcinoma cell lines Reviewed

    Yasumichi Toki, Katsunori Sasaki, Hiroki Tanaka, Masayo Yamamoto, Mayumi Hatayama, Satoshi Ito, Katsuya Ikuta, Motohiro Shindo, Takumu Hasebe, Shunsuke Nakajima, Koji Sawada, Mikihiro Fujiya, Yoshihiro Torimoto, Takaaki Ohtake, Yutaka Kohgo

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   476 ( 4 )   501 - 507   2016.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.bbrc.2016.05.153

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  • Non-transferrin-bound iron assay system utilizing a conventional automated analyzer Reviewed

    Satoshi Ito, Katsuya Ikuta, Daisuke Kato, Kotoe Shibusa, Noriyasu Niizeki, Hiroki Tanaka, Lynda Addo, Yasumichi Toki, Mayumi Hatayama, Junki Inamura, Motohiro Shindo, Katsunori Sasaki, Naomi Iizuka, Mikihiro Fujiya, Yoshihiro Torimoto, Yutaka Kohgo

    CLINICA CHIMICA ACTA   437   129 - 135   2014.11

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    DOI： 10.1016/j.cca.2014.07.013

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  • GLP-1は中枢神経系に作用してLPSによる腸管透過性亢進を抑制する

    船山拓也, 野津司, 野津司, 石王応知, 五十嵐将, 鷲見千紘, 齋藤豪志, 山本昌代, 畑山真弓, 土岐康通, 進藤基博, 奥村利勝, 奥村利勝

    日本潰瘍学会プログラム・抄録集(CD-ROM)   51st   2024

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  • Usefulness of Reticulocyte Hemoglobin Equivalent for Diagnosis of Iron Deficiency

    Yasumichi Toki, Katsuya Ikuta, Masayo Yamamoto, Mayumi Hatayama, Motohiro Shindo, Mikihiro Fujiya, Toshikatsu Okumura

    BLOOD   128 ( 22 )   2016.12

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    Language：English   Publishing type：Research paper, summary (international conference)  

    DOI： 10.1182/blood.V128.22.3621.3621

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