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English: Suratsawadee Promsuwan, Kazuki Sawamoto, Liang Xu, Mayumi Nagashimada, Naoto Nagata, Yumi Takiyama, A natural Nrf2 activator glucoraphanin improves hepatic steatosis in high-fat diet-induced obese male mice associated with AMPK activation , Diabetology International , 2023
English: Takiyama T, Sera T, Nakamura M, Hoshino M, Uesugi K, Horike SI, Meguro-Horike M, Bessho R, Takiyama Y, Kitsunai H, Takeda Y, Sawamoto K, Yagi N, Nishikawa Y, Takiyama Y., A maternal high-fat diet induces fetal origins of NASH-HCC in mice , Scientific Reports , vol.12 (1) (p.13136 - ) , 2022
English: Tomoe Abe, Yasutaka Takeda, Takao Takiyama, Ayaka Sasaki, Ryoichi Bessho, Mao Sato, Hiroya Kitsunai, Hidemitsu Sakagami, Atsuko Abiko, Koji Imai, Sayaka Yuzawa, Mishie Tanino, Yumi Takiyama, A case of insulinoma diagnosed postpartum with hypoglycemic symptoms that were masked during pregnancy , Clin Case Rep , vol.9 (4) (p.1991 - 1998) , 2021
English: Bessho R, Takiyama Y, Takiyama T, Kitsunai H, Takeda Y, Sakagami H, Ota T., Hypoxia-inducible factor-1α is the therapeutic target of the SGLT2 inhibitor for diabetic nephropathy , Scientific Reports , vol.9 (1) (p.14754 - ) , 2019
English: Takeda Y, Fujita Y, Bessho R, Sato M, Abe T, Yanagimachi T, Sakagami H, Abiko A, Takiyama Y, Ota T, Haneda M., Increment of plasma glucose by exogenous glucagon is associated with present and future renal function in type 2 diabetes: a retrospective study from glucagon stimulation test , BMC Endocr Disord . , vol.19 (1) (p.99 - ) , 2019
English: Takiyama Y, Sera T, Nakamura M, et al., Impacts of Diabetes and an SGLT2 Inhibitor on the Glomerular Number and Volume in db/db Mice, as Estimated by Synchrotron Radiation Micro-CT at SPring-8. , EBioMedicine , vol.36 (p.329 - 346) , 2018
English: Jun Watanabe, Jun Honjyo, Yuichi Makino, Yukihiro Fujita, Masatoshi Tateno, Masakazu Haneda, Role of IGFBP7 in Diabetic Nephropathy: TGF-β1 Induces IGFBP7 via Smad2/4 in Human Renal Proximal Tubular Epithelial Cells. , PLOS ONE , 2016 , (IF:3.234)
English: Yanagimachi T, Fujita Y, Takeda Y, Honjo J, Atageldiyeva KK, Takiyama Y, Abiko A, Makino Y, Kieffer TJ, Haneda M., Pancreatic glucose-dependent insulinotropic polypeptide (GIP) (1-30) expression is upregulated in diabetes and PEGylated GIP(1-30) can suppress the progression of low-dose-STZ-induced hyperglycaemia in mice. , Diabetologia , vol.59 (3) (p.533 - 541) , 2016
English: Kitsunai H, Makino Y, Sakagami H, Mizumoto K, Yanagimachi T, Atageldiyeva K, Takeda Y, Fujita Y, Abiko A, Takiyama Y, Haneda M., High glucose induces platelet-derived growth factor-C via carbohydrate response element-binding protein in glomerular mesangial cells. , Physiol Rep , 2016
English: Matsuzawa K, Izawa S, Ohkura T, Ohkura H, Ishiguro K, Yoshida A, Takiyama Y, Haneda M, Shigemasa C, Yamamoto K, Taniguchi S., Implication of intracellular localization of transcriptional repressor PLZF in thyroid neoplasms. , BMC Endocr Disord , vol.14 (52) , 2014
English: Yumi Takiyama, Masakazu Haneda, Hypoxia in Diabetic Kidneys. , Biomed Res Int , vol.Ebub , 2014
English: Agatsuma, Yumi Takiyama, Jun Honjo, Yukihiro Fujita, Tsuyoshi Yanagimachi, Hiroya Kitsunai, Hidemitsu Sakagami, Yuichi Makino, Masakazu Haneda. , TGF-beta1 Inhibits Sodium-Glucose Cotransporter 2 (SGLT2) Expression in Human Renal Proximal Cells. , Diabetes , 2013
English: YUMI TAKIYAMA, JUN HONJO, YUKIHIRO FUJITA, TSUYOSHI YANAGIMACHI, HIROYA KITSUNAI, HIDEMITSU SAKAGAMI, YUICHI MAKINO, MASAKAZU HANEDA, HIF-1α as a Novel Molecular Target in Anticancer Effects of Metformin. , Diabetes , vol.61 (supple.) (p.A235 - A236 ) , 2012 , (IF:8.3)
English: Takeda Y, Fujita Y, Honjo J, Yanagimachi T, Sakagami H, Takiyama Y, Makino Y, Abiko A, Kieffer TJ, Haneda M., Reduction of both beta cell death and alpha cell proliferation by dipeptidyl peptidase-4 inhibition in a streptozotocin-induced model of diabetes in mice. , Diabetologia , vol.55 (2) (p.404 - 412) , 2012 , (IF:6.814)
English: Yumi Takiyama, Manami Kobayashi, Yukihiro Fujita, Yasutaka Takeda, Jun Honjo, Tsuyoshi Yanagimachi, Hiroya Kitsunai, Hidemitu Sakagami, Yuichi Makino, Masakazu Haneda., Metallothionein Overexpression May Underlie Tubular Injury in Type 2 Diabetic Nephropathy. , Journal of the American Society of Nephrology , vol.22 (supple) (p.242A) , 2011 , (IF:9.663)
English: MANAMI KOBAYASHI, YUMI TAKIYAMA, YUKIHIRO FUJITA, JUN HONJO, YASUTAKA TAKEDA, HIROYA KITSUNAI, HIDEMITSU SAKAGAMI, YUICHI MAKINO, MASAKAZU HANEDA, Dysregulation of Metallothionein in a Rat Model of Type 2 Diabetic Nephropathy: Divergent Roles of Hypoxia and TGF-β1. , Diabetes , vol.60 (suppple) (p.A168) , 2011 , (IF:8.3)
English: Takiyama Y, Harumi T, Watanabe J, Fujita Y, Honjo J, Shimizu N, Makino Y, Haneda M., Tubular Injury in a Rat Model of Type 2 Diabetes Is Prevented by Metformin: A Possible Role of Hypoxia Inducible Factor-1α Expression and Oxygen Metabolism. , Diabetes , vol.60 (3) (p.981 - 992) , 2011 , (IF:8.889)
English: Yumi Takiyama, Jun Watanabe, Tatsuo Harumi, Yukihiro Fujita, Jun Honjo, Norihiko Shimizu, Yuichi Makino, Yasutaka Takeda, Masakazu Haneda., Renal Tubulointerstitial Fibrosis in Type 2 Diabetic Rats is Prevented by Metformin:A Possible Role of HIF-1a Expression and Oxygen Metabolism. , Diabetes , vol.59 (supple) (p.A249) , 2010 , (IF:8.3)
English: Yumi Takiyama, Jun Watanabe, Jun Honjyo, Hidemitsu Sakagami, Yuichi Makino, Yasutaka Takeda, Yukihiro Fujita, Masatoshi Tateno, Masakazu Haneda., LC-MS/MS-based proteomic analysis of the proteins secreted by human renal proximal tubular epithelia cells (HRPTEC) reveals IGFBP-rP1 as a potential proteomic biomarker associated with diabetic nephropathy. , Journal of the American Society of Nephrology , vol.20 (supple) , 2009 , (IF:9.663)
English: Jun Watanabe, Yumi Takiyama, Jun Honjyo, Hidemitsu Sakagami, Yuichi Makino, Yasutaka Takeda, Yukihiro Fujita, Masatoshi Tateno, Masakazu Haneda., Insulin-like Growth Factor Binding Protein-related Protein 1 (IGFBP-rP1) as a Possible Biomarker of Proximal Tubule Injury in Type-2 Diabetic Patients with Proteinuria. , Diabetes , vol.58 (supple) (p.A216) , 2009 , (IF:8.3)
English: Miyauchi K, Takiyama Y, Honjyo J, Tateno M, Haneda M, Upregulated IL-18 expression in type 2 diabetic subjects with nephropathy: TGF-β1 enhanced IL-18 expression in human renal proximal tubular epithelial cells. , DIABETES RESEARCH AND CLINICAL PRACTICE , vol.83 (p.190 - 199) , 2009 , (IF:2.754)
English: Yumi Takiyama, Jun Watanabe, Jun Honjyo, Tsubasa Isoe, Hidemitsu Sakagami, Yuichi Makino, Yukihiro Fujita, Masakazu Haneda., Metformin Attenuates the Profibrotic Induced by TGF-β1 in Human Renal Proximal Tubular Cells (HRPTECs). , Journal of the Americal Society of Nephrology , vol.19 (supple) (p.411A - 412A) , 2008 , (IF:9.663)
English: Jun Watanabe, Yumi Takiyama, Jun Honjyo, Tsubasa Isoe, Hidemitsu Sakagami, Yuichi Makino, Yukihiro Fujita, Masakazu Haneda., TGF-β1 upregulates insulin-like growth factor binding protein (IGFBP)-7 expression in human renal proximal tubular epithelial cell(HRPTEC). , Diabetologia , vol.51 (supple) (p.S480) , 2008 , (IF:6.814)
English: Yumi Takiyama, Jun Watanabe, Jun Honjyo, Tsubasa Isoe, Hidemitsu Sakagami, Ykihiro Fujtita, Yuichi Makino, Masakazu Haneda., Metformin Inhibits the Expression of HIF-1α and PAI-1 through the Inhbition of Mitochondroal Respiratory Chain Complex I in Human Renal Proximal Tubular Epithelial Cells (HRPTECs) in Culture. , Diabetes , vol.57 (supple) (p.A215) , 2008 , (IF:8.3)
English: Yumi Takiyama, Jun Honjyo, Jun Watanabe, Tsubasa Isoe, Kensaku Okamoto, Yuichi Makino, Masakazu Haneda., Metformin Inhibits the Expression of HIF-1α and PAI-1 in Human Renal Proximal Tubular Epithelial Cells (HRPTECs) in Culture. , Journal of the American Society of Nephrology , vol.18 (supple) (p.654A) , 2007 , (IF:9.663)
English: Yanai M, Sato K, Aoki N, Takiyama Y, Oikawa K, Kobayashi H, Kimura S, Harabuchi Y, Tateno M, The role of CCL22/macrophage-derived chemokine in allergic rhinitis. , Clinical Immunology , vol.125 (p.291 - 298) , 2007 , (IF:4.046)
English: Yumi Takiyama, Kazunari Miyauchi, Jun Honjyo, Seiji Uebori, Tsubasa Isoe, Atsuko Abiko, Hiroshi Ito, Masatoshi Tateno, Masakazu Haneda., Interleukin-18(IL-18) Expression is Up-Regulated in Renal Tubular Cells in Type 2 Diabetic Subjects with Nephropathy. , Diabetes , vol.55 (supple) (p.A184) , 2006 , (IF:8.3)
English: Oikawa K, Kimura S, Aoki N, Atsuta Y, Takiyama Y, Nagato T, Yanai M, Kobayashi H, Sato K, Sasajima T, Tateno M, Neuronal calcium sensor protein visinin-like protein-3 interacts with microsomal cytochrome b5 in a Ca2+-dependent manner. , JOURNAL OF BIOLOGICAL CHEMISTRY , vol.279 (p.15142 - 15152) , 2004 , (IF:5.328)
English: Takiyama Y, Miyokawa N, Sugawara A, Kato S, Ito K, Sato K, Oikawa K, Kobayashi H, Kimura S, Tateno M, Decreased expression of retinoid X receptor (RXR) isoforms in human thyroid carcinomas. , J Clin Endocrinol Metab , vol. 89 (p.5851 - 5861) , 2004 , (IF:6.202)
English: Nochi H, Aoki N, Oikawa K, Yanai M, Takiyama Y, Atsuta Y, Kobayashi H, Sato K, Tateno M, Matsuno T, Katagiri M, Xing A, Kimura S., Modulation of hepatic granulomatous responses by transgene expression of DAP12 or TREM-1-Ig molecules. , American Journal of Pathology , vol.62 (p.1191 - 1201) , 2003 , (IF:5.224)
English: Takiyama Y, Miyokawa N, Tokusashi Y, Ito K, Kato S, Kimura S, Sato K, Katagiri M, Thyroid-stimulating hormone induces interleukin-18 gene expression in FRTL-5 cells: immunohistochemical detection of interleukin-18 in autoimmune thyroid disease. , Thyroid , vol.12 (p.935 - 943) , 2002 , (IF:4.792)
English: Aoki N, Kimura S, Takiyama Y, Atsuta Y, Abe A, Sato K, Katagiri M., The role of the DAP12 signal in mouse myeloid differentiation. , Journal of Immunology , vol.165 (p.3790 - 3796) , 2000 , (IF:5.788)
English: Segev DL, Saji M, Phillips GS, Westra WH, Takiyama Y, Piantadosi S, Smallridge RC, Nishiyama RH, Udelsman R, Zeiger MA., Polymerase chain reaction-based microsatellite polymorphism analysis of follicular and Hürthle cell neoplasms of the thyroid. , JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM , vol.83 (p.2036 - 2042) , 1998 , (IF:6.495)
English: Egawa S, Futami H, Takasaki K, Iihara M, Okamoto T, Kanbe M, Ohi T, Saio Y, Miyauchi A, Takiyama Y, Koga M, Miyanaga K, Inoue K, Mitsuyama S, Nomura Y, Takei H, Mugiya S, Ishida O, Zeze F, Shakutsui S, Inoue H, Oya H, Yoshimura A, Ishizuka S, Yamaguchi K, Genotype-phenotype correlation of patients with multiple endocrine neoplasia type 2 in Japan. , JAPANESE JOURNAL OF CLINICAL ONCOLOGY , vol.28 (p.590 - 596) , 1998 , (IF:1.856)
English: Zeiger MA, Saji M, Gusev Y, Westra WH, Takiyama Y, Dooley WC, Kohn LD, Levine MA., Thyroid-specific expression of cholera toxin A1 subunit causes thyroid hyperplasia and hyperthyroidism in transgenic mice. , Endocrinology , vol.138 (p.3133 - 3140) , 1997 , (IF:4.993)
English: Kanri R, Takiyama Y, Makino I., Effects of bile acids on iodide uptake and deoxyribonucleic acid synthesis in porcine thyroid cells in primary culture. , Thyroid , vol.6 (p.467 - 474) , 1996 , (IF:4.792)
English: Zeiger MA, Takiyama Y, Bishop JO, Ellison AR, Saji M, Levine MA., Adenoviral infection of thyroid cells: a rationale for gene therapy for metastatic thyroid carcinoma. , Surgery , vol.120 (p.921 - 925) , 1996 , (IF:3.406)
English: Takiyama Y, Tanaka H, Takiyama Y, Makino I., The effects of hydrocortisone and RU486 (mifepristone) on iodide uptake in porcine thyroid cells in primary culture. , Endocrinology , vol.135 (p.1972 - 1979) , 1994 , (IF:4.993)
English: Tanaka H, Fukawa E, Hirano H, Makino Y, Aoki A, Morikawa Y, Takiyama Y, Tani T, Makino I., In vitro monitoring activation by the ligands and specific DNA-binding of the glucocorticoid receptors. , Endocrinologica Japonica (Endocrine Journal) , vol.39 (p.477 - 483) , 1992 , (IF:2.027)
English: Isozaki O, Tsushima T, Emoto N, Saji M, Tsuchiya Y*, Demura H, Sato Y, Shizume K, Kimura S, Kohn LD. (*Tsuchiya:Maiden name), Methimazole regulation of thyroglobulin biosynthesis and gene transcription in rat FRTL-5 thyroid cells. , Endocrinology , vol.128 (p.3113 - 3121) , 1991 , (IF:4.993)
English: Tsuchiya Y*, Saji M, Isozaki O, Arai M, Tsushima T, Shizume K.(*Tsuchiya:Maiden name), Effect of lithium on deoxyribonucleic acid synthesis and iodide uptake in porcine thyroid cells in culture , Endocrinology , vol.126 (p.460 - 465) , 1990 , (IF:4.993)
English: Saji M, Isozaki O, Tsushima T, Arai M, Miyakawa M, Ohba Y, Tsuchiya Y*, Sano T, Shizume K.(*Tsuchiya:Maiden Name), The inhibitory effect of iodide on growth of rat thyroid (FRTL-5) cells. , Acta Endocrinologica(Copenh) , vol.119 (p.145 - 151) , 1988
English: Muratsugu M, Tsuchiya Y*, Makino M.(*Tsuchiya:Maiden name), A 3, 3’, 5-triiodothyronine autoantibody (IgG, lambda) in a case of Hashimoto’s thyroiditis. , Clin Chim Acta , vol.178 (p.171 - 180) , 1988 , (IF:2.535)
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