Updated on 2026/03/04

写真a

 
ITOH Toshihiro
 
Organization
School of Medicine Nursing Course Nursing
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Degree

  • Doctor (Environmental Science) ( 1992.12   Hokkaido University )

  • Master of Environmental Science ( 1988.3   Hokkaido University )

Research Interests

  • Hygiene

  • Health Science

  • Health Education

  • Public Health

  • 環境保健学

Research Areas

  • Life Science / Healthcare management, medical sociology

  • Life Science / Hygiene and public health (non-laboratory)

  • Life Science / Hygiene and public health (laboratory)

Education

  • Hokkaido University   Graduate School, Division of Environmental Science

    - 1992.12

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    Country： Japan

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  • Hokkaido University   Graduate School of Environmental Sciences   Department of Socio-Environmental Studies

    1986.4 - 1992.12

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  • University of the Ryukyus

    1980.4 - 1984.3

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    Country： Japan

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Research History

  • Asahikawa Medical College   Department of Nursing   Professor

    2014.6

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  • Asahikawa Medical College   Department of Health Science   Associate Professor

    2012.4 - 2014.6

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  • Asahikawa Medical College   Department of Health Science   Assistant Professor

    2003.4 - 2012.3

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  • Asahikawa Medical College   Department of Hygiene   Research Assistant

    1995.3 - 2003.3

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  • 日本学術振興会 特別研究員

    1994.4 - 1995.3

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  • Cornell University Medical College, Postodoctoral Researcher

    1993.5 - 1995.2

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Professional Memberships

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Papers

  • Allergy and immunotoxicology in preventive and clinical medicine from theory to practice: Environmental factors in bronchial asthma Reviewed

    Takeshi Hisada, Yasumitsu Nishimura, Kunio Dobashi, Takahiko Yoshida, Toshihiro Itoh, Yasuo Morimoto, Narifumi Suganuma, Qing Li, Hiroo Wada, Atsushi Ueda, Fujio Kayama, Kazuhiro Satoh, Minoru Satoh, Eiji Shibata, Tatsuya Takeshita, Hiroyuki Yanagisawa, Masashi Tsunoda

    SANGYO EISEIGAKU ZASSHI   67 ( 1 )   1 - 8   2025.1

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    Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Japan Society for Occupational Health  

    DOI： 10.1539/sangyoeisei.2024-009-a

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  • アフリカ諸国から公衆衛生を学ぶ JICA研修が看護初学者にもたらす成果

    藤井 智子, 水口 和香子, 塩川 幸子, 伊藤 俊弘, 神田 浩路

    日本公衆衛生学会総会抄録集   83回   612 - 612   2024.10

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    Language：Japanese   Publisher：日本公衆衛生学会  

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  • 本邦における複数言語を用いたアフリカ地域保健人材育成研修の評価

    神田 浩路, 伊藤 俊弘, 藤井 智子, 塩川 幸子, 吉田 貴彦

    日本公衆衛生学会総会抄録集   83回   611 - 611   2024.10

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    Language：Japanese   Publisher：日本公衆衛生学会  

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  • COVID-19流行にかかる本邦への入国制限緩和後に実施したアフリカ地域保健人材育成研修

    神田 浩路, 伊藤 俊弘, 藤井 智子, 塩川 幸子, 吉田 貴彦

    日本公衆衛生学会総会抄録集   82回   548 - 548   2023.10

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    Language：Japanese   Publisher：日本公衆衛生学会  

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  • [Allergy and immunotoxicology in preventive and clinical medicine from theory to practice: Occupational allergy and isocyanate-induced asthma].

    Kunio Dobashi, Takahiko Yoshida, Yasuo Morimoto, Atsuhi Ueda, Toshihiro Itoh, Hiroo Wada, Fujio Kayama, Kazuhiro Satoh, Minoru Satoh, Eiji Shibata, Narufumi Suganuma, Tatsuya Takeshita, Masashi Tsunoda, Yasumitsu Nishimura, Hiroyuki Yanagisawa, Qing Li

    Sangyo eiseigaku zasshi = Journal of occupational health   65 ( 1 )   1 - 8   2023.1

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    Genetic and environmental factors and their interactions cause diseases and deteriorate health (Genetic and Environmental Interaction). Exposure to environmental factors plays a major role in the deterioration of health in the workplace.Occupational asthma (OA) is a common disorder in the workplace. Approaches to OA are well described and discussed in "Japanese Guideline for Diagnosis and Management of Occupational Allergic Diseases" by the Japanese Society of Occupational and Environmental Allergy. According to the guideline, OA and work-aggravated asthma comprise work-related asthma, and OA can be further divided into two disease entities: sensitizer-induced OA and irritant-induced OA. The guidelines also describe diagnostic and therapeutic strategies for OA. Since a definitive diagnosis of OA requires a comprehensive decision based on a detailed interview on clinical symptoms related to employment status and clinical tests, including inhalation tests of suspected substances as needed, the possibility of OA should be considered as the first step toward diagnosis of the patient. Otherwise, OA may not be diagnosed. Therapeutic strategies include exposure avoidance, environmental arrangements in the workplace, utilization of social resources for workers, and conventional pharmacotherapy for asthma.Artificially synthesized small compounds are used in various industries and can cause allergies. For example, isocyanates are small compounds in the -NCO group, which have been toxicologically studied. It was later shown that isocyanate could cause various nontoxic adverse health effects, including allergic reactions. Since small agents with low molecular weights bind to proteins, detecting their specific immunoglobulin E (IgE) antibodies targeting small compounds is generally difficult. In contrast, isocyanate-specific IgE antibodies are detectable in individuals with isocyanate allergies.Suspecting OA is essential in cases exposed to newly synthesized compounds, or to those that are already known but applied to new uses, which can be better understood and predicted by studying the health effects of isocyanates.Academic interest in various issues related to allergies, immunology, and toxicology in the workplace includes clinical medicine, epidemiology, and epigenetics related to environmental exposure. Further advanced research in these areas is necessary and promising.

    DOI： 10.1539/sangyoeisei.2021-040-A

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  • 通所型介護予防事業における高齢者の物忘れに対する不安感と関連 Reviewed

    澤崎勇気, 藤井智子, 伊藤俊弘

    北海道地域福祉研究   24   15 - 29   2021.3

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

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  • The relationship between prenatal psychological stress and placental abruption in Japan, The Japan Environment and Children's Study (JECS). International journal

    Yasuyuki Kawanishi, Eiji Yoshioka, Yasuaki Saijo, Toshihiro Itoh, Toshinobu Miyamoto, Kazuo Sengoku, Yoshiya Ito, Sachiko Ito, Chihiro Miyashita, Atsuko Araki, Toshiaki Endo, Kazutoshi Cho, Hisanori Minakami, Reiko Kishi

    PloS one   14 ( 7 )   e0219379   2019

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    BACKGROUND: Prenatal psychological stress may increase the risk of placental abruption (PA). This study aimed to clarify the effects of psychological distress during pregnancy and exposure to stressful life events in the year before or during pregnancy on the occurrence of PA in Japanese women. METHODS: Using a nationwide prospective birth cohort study, we obtained data from 103,099 women between January 2011 and March 2014. Information on exposure to 14 stressful life events and psychological distress (Kessler 6 scale) was collected using a self-administered questionnaire during pregnancy. Clinical diagnoses of PA were obtained from medical records. A total of 80,799 women with singleton births were analyzed using logistic regression models that adjusted for possible confounders. RESULTS: PA was diagnosed in 335 (0.4%) women. There was no significant difference in the Kessler 6 score during pregnancy between the PA group and non-PA group. Exposure to the death of a child in the year before or during pregnancy was significantly associated with PA in multigravid women (adjusted odds ratio [aOR] 3.57; 95% confidence interval [CI] 1.50-8.34). A spouse's loss of employment was significantly associated with PA in parous women (aOR 3.25; 95% CI 1.40-7.56). CONCLUSIONS: This study identified the possible effects of exposure to the death of a child on PA occurrence that adjusted for important confounding factors.

    DOI： 10.1371/journal.pone.0219379

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  • Relationships of job demand, job control, and social support on intention to leave and depressive symptoms in Japanese nurses.

    Yasuaki Saijo, Eiji Yoshioka, Yasuyuki Kawanishi, Yoshihiko Nakagi, Toshihiro Itoh, Takahiko Yoshida

    Industrial health   54 ( 1 )   32 - 41   2016

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    This study aims to elucidate the relationships among the factors of the demand-control-support model (DCS) on the intention to leave a hospital job and depressive symptoms. Participants included 1,063 nurses. Job demand, job control, and support from supervisors were found to be significantly related to both the intention to leave and depressive symptoms. Based on the odds ratios per 1 SD change in the DCS factors, low support from supervisors was found to be most related to the intention to leave, and low job control was found to be most related to depressive symptoms. In models that did not include "job demand" as an independent variable, 60-h working weeks were found to have a significantly higher odds ratio for depressive symptoms. Support from supervisors is more important in preventing intention to leave and depressive symptoms among nurses than is support from co-workers. Improving job control and avoiding long working hours may be important to prevent depressive symptoms.

    DOI： 10.2486/indhealth.2015-0083

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  • Synergistic interaction between job control and social support at work on depression, burnout, and insomnia among Japanese civil servants. International journal

    Yasuaki Saijo, Shigeru Chiba, Eiji Yoshioka, Yoshihiko Nakagi, Toshihiro Ito, Kazuyo Kitaoka-Higashiguchi, Takahiko Yoshida

    International archives of occupational and environmental health   88 ( 2 )   143 - 52   2015.2

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    PURPOSE: To elucidate whether low job control and low social support at work have synergistic interaction on mental health. The synergistic interaction was also analyzed after stratification by high and low job demands. METHODS: Participants were 2,121 local government employees in Asahikawa city, Japan. The Brief Job Stress Questionnaire was used to assess job demands, job control, and social support. Depression was assessed using the Patient Health Questionnaire-9. The Maslach Burnout Inventory-General Survey was used to assess burnout. Insomnia was assessed using the Athens Insomnia Scale. Possible confounder-adjusted logistic regression analyses were performed to obtain odds ratios for depression, burnout, and insomnia, and synergy indices between job control and social support at work were assessed. RESULTS: The synergy indices among men and women, respectively, were 2.08 (80 % confidence interval: 1.01, 4.27) and 1.98 (0.67, 5.89) for depression, 1.79 (1.28, 2.51) and 2.62 (1.07, 6.40) for burnout, and 1.92 (1.22, 3.02) and 2.77 (0.43, 18.01) for insomnia. Men with high job demands had higher synergistic interaction on depression and burnout, compared to men with low job demands, and women with low job demands had higher synergistic interaction between job control and social support at work on burnout and insomnia, compared to women with high job demands. CONCLUSIONS: There were more-than-additive interactions of job control and social support at work on depression, burnout, and insomnia. After stratification by job demands, the synergistic interaction may be different between men and women. To assess job stress, it is necessary to consider the interactive effect of not only job demands and job control but also job control and social support at work.

    DOI： 10.1007/s00420-014-0945-6

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  • Biomonitoring of mercury, cadmium, and lead exposure in Japanese children: a cross-sectional study.

    Cimi Ilmiawati, Takahiko Yoshida, Toshihiro Itoh, Yoshihiko Nakagi, Yasuaki Saijo, Yoshihiko Sugioka, Mineshi Sakamoto, Akihiko Ikegami, Masanori Ogawa, Fujio Kayama

    Environmental health and preventive medicine   20 ( 1 )   18 - 27   2015.1

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    OBJECTIVES: To measure current Hg, Cd, and Pb exposure in Japanese children, and to estimate dietary intakes of foods responsible for high body burden. METHODS: Blood, hair, and urine samples were collected from 9 to 10-year-old 229 children in Asahikawa and measured for Hg, Cd, and Pb in these matrices. Diet history questionnaire was used to estimate intake of marine foods and other food items. Hg level was measured by cold vapor atomic absorption spectrometry. Cd and Pb levels were determined with inductively coupled plasma mass spectrometry. RESULTS: Geometric mean (GM) of blood Hg, Cd, and Pb was 4.55 μg/L, 0.34 μg/L, and 0.96 μg/dL, respectively. Urinary Cd level was 0.34 μg/g creatinine (GM) and hair Hg was 1.31 μg/g (GM). Approximately one-third (35%) of blood samples had Hg level above the U.S. EPA reference dose (RfD; 5.8 μg/L). Hair Hg level exceeded U.S. EPA RfD (1.2 μg/g) in 59 % samples. Children in the upper quartile of blood Hg level had significantly higher intake of large predatory fish species compared to those in the lower quartile of blood Hg. CONCLUSIONS: Those with high blood Hg level may be explained by more frequent intake of big predatory fish. Cd and Pb exposure is generally low among Japanese children. As no safety margin exists for Pb exposure and high exposure to MeHg is noted in Japanese population; periodic biomonitoring and potential health risk assessment should continue in high-risk populations, notably among children.

    DOI： 10.1007/s12199-014-0416-4

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  • [Effects of prenatal yoga: a systematic review of randomized controlled trials]. Reviewed

    Yasuyuki Kawanishi, Sharon J B Hanley, Kazuki Tabata, Yoshihiko Nakagi, Toshihiro Ito, Eiji Yoshioka, Takahiko Yoshida, Yasuaki Saijo

    [Nihon koshu eisei zasshi] Japanese journal of public health   62 ( 5 )   221 - 31   2015

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    OBJECTIVES: While several studies on the preventive and therapeutic effects of prenatal yoga (maternity yoga) have been reported in recent years, there has been no systematic review on the effects of prenatal yoga based on randomized controlled trials (RCT). The purpose of this study, therefore, was to systematically review the literature to clarify the effects of prenatal yoga in RCT focusing on the contents of the intervention, the intervention means, and the frequency of practice. METHODS: The literature search was performed using the electronic database, PubMed. The inclusion criteria were RCT, pregnant women, and yoga intervention. RESULTS: In total, 54 citations were found; of these, eight studies (10 reports) were included in the final analysis. In four studies on healthy pregnant women, significant improvement in pain and pleasure at delivery, duration of delivery, perceived stress levels during pregnancy, anxiety levels, depression, pregnancy-related experiences, quality of life, and interpersonal relationships were compared to those in the control group. In two studies on depressed pregnant women, one reported that depression, anxiety levels, anger levels, leg pain, and back pain significantly improved with yoga, while the other found no differences from the control group. In one study of high-risk pregnant women with morbidity factors such as obesity or advanced age, yoga resulted in significantly fewer cases of pregnancy-induced hypertension, gestational diabetes, and intrauterine growth restriction, as well as a decrease in perceived stress levels. In one study on pregnant women with pelvic pain, the median pain score was lower in the yoga group. Regarding the contents of the intervention, while the two studies for depressed pregnant women only included physical postures, the remaining six studies also included breathing technique and meditation. Interventions were performed using lectures by instructors alone or together with self-teaching. The frequency of the intervention varied within each study. CONCLUSION: The findings suggest that prenatal yoga may help reduce pelvic pain. It may also improve mental condition (stress, depression, anxiety, etc.), physical condition (pain and pleasure at the delivery, etc.), and perinatal outcomes (obstetrical complications, delivery time, etc.). However, further studies are needed. The contents of the intervention, the intervention means, and the frequency varied with each study. Thus, it is necessary to further examine the content of effective interventions, intervention means, and frequency that suit participant's characteristics and each outcome. Further research in this field, particularly randomized controlled trials, is merited.

    DOI： 10.11236/jph.62.5_221

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  • Effects of work burden, job strain and support on depressive symptoms and burnout among Japanese physicians. International journal

    Yasuaki Saijo, Shigeru Chiba, Eiji Yoshioka, Yasuyuki Kawanishi, Yoshihiko Nakagi, Toshihiro Itoh, Yoshihiko Sugioka, Kazuyo Kitaoka-Higashiguchi, Takahiko Yoshida

    International journal of occupational medicine and environmental health   27 ( 6 )   980 - 92   2014.12

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    OBJECTIVES: Days off, on call, night duty, working hours and job stress can affect physicians' mental health, and support from supervisors and co-workers may have a buffering effect. This study elucidates whether job strain and job factors affect physicians' mental health, and whether support from supervisors and co-workers has a protective effect on their mental health. MATERIAL AND METHODS: The subjects included 494 physicians. The Brief Job Stress Questionnaire (BJSQ) was used to evaluate job demand, job control and support. High job strain was defined as a combination of high job demand and low job control. Depressive symptoms were assessed using the Patient Health Questionnaire-9. The Maslach Burnout Inventory-General Survey was used to evaluate burnout. Possible confounder adjusted logistic regression analyses were performed to obtain odds ratios for depressive symptoms and burnout. RESULTS: As per the analysis, high job strain had significantly higher odds ratios, and support from co-workers had significant protective odds ratios for depressive symptoms. High job strain and having only 2-4 days off per month (compared to > 8 days off per month) had significantly higher odds ratios, and support from co-workers had significant protective odds ratios for burnout. CONCLUSIONS: High job strain was related to depressive symptoms and burnout, and support from co-workers had a buffering effect on depressive symptoms and burnout. An inadequate number of days off was related to burnout. Assessment of job strain may be a good tool to measure physicians' mental health, and a sufficient number of days off may be needed to prevent burnout.

    DOI： 10.2478/s13382-014-0324-2

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  • 北海道における高断熱建築物の夏季の室内温度について

    中木 良彦, 伊藤 俊弘, 西條 泰明, 吉岡 英治, 杉岡 良彦, 川西 康之, 吉田 貴彦

    産業衛生学雑誌   56 ( 臨増 )   515 - 515   2014.5

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    Language：Japanese   Publisher：(公社)日本産業衛生学会  

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  • 発症原因となった飲料水変更にともなう砒素曝露軽減による慢性砒素中毒症状の改善

    吉田 貴彦, 山内 博, 相川 浩幸, 熊谷 嘉人, 藤本 亘, 香山 不二雄, 伊藤 俊弘, 杉岡 良彦, 中木 良彦, 西條 泰明, 吉岡 英治, 川西 康之, 李 きん, 皮 静波, 孫 貴範

    産業衛生学雑誌   56 ( 臨増 )   438 - 438   2014.5

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    Language：Japanese   Publisher：(公社)日本産業衛生学会  

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  • Relationships of gamma-glutamyltransferase and beta 2-microglobulin on high sensitivity C-reactive protein among Japanese elementary school children Reviewed

    Koji Kamibayashi, Yasuaki Saijo, Toshihiro Itoh, Fujio Kayama, Takahiko Yoshida

    Journal of Pediatric Endocrinology and Metabolism   27 ( 7-8 )   643 - 650   2014.2

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    DOI： 10.1515/jpem-2013-0479

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  • In vitro endocrine disruption potential of organophosphate flame retardants via human nuclear receptors. International journal

    Hiroyuki Kojima, Shinji Takeuchi, Toshihiro Itoh, Mitsuru Iida, Satoshi Kobayashi, Takahiko Yoshida

    Toxicology   314 ( 1 )   76 - 83   2013.12

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    Various organophosphate flame retardants (OPFRs) are widely used in building materials, textiles and electric appliances, and have been reported to cause indoor environmental pollution in houses and office buildings. In this study, using cell-based transactivation assays, we characterized the agonistic and/or antagonistic activities of 11 OPFRs against human nuclear receptors; estrogen receptor α (ERα), ERβ, androgen receptor (AR), glucocorticoid receptor (GR), thyroid hormone receptor α1 (TRα1), TRβ1, retinoic acid receptor α (RARα), retinoid X receptor α (RXRα), pregnane X receptor (PXR), peroxisome proliferator-activated receptor α (PPARα), and PPARγ. Of the 11 OPFRs tested, triphenyl phosphate (TPhP) and tricrecyl phosphate (TCP) showed ERα and/or ERβ agonistic activity. In addition, tributyl phosphate (TBP), tris(1,3-dichloro-2-propyl) phosphate (TDCPP), TPhP and TCP showed AR antagonistic activity, and TBP, tris(2-ethylhexyl) phosphate (TEHP), TDCPP, TPhP and TCP showed GR antagonistic activity. Furthermore, we found that seven compounds, TBP, tris(2-chloro-1-methylethyl) phosphate (TCPP), TEHP, tris(2-butoxyethyl) phosphate (TBEP), TDCPP, TPhP, and TCP, display PXR agonistic activity. However, none of test compounds showed agonistic or antagonistic activity against TRα/β, or agonistic activity against RARα, RXRα or PPARα/γ. Taken together, these results suggest that several OPFRs may have potential endocrine disrupting effects via ERα, ERβ, AR, GR and PXR.

    DOI： 10.1016/j.tox.2013.09.004

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  • Job stress and burnout among urban and rural hospital physicians in Japan. International journal

    Yasuaki Saijo, Shigeru Chiba, Eiji Yoshioka, Yasuyuki Kawanishi, Yoshihiko Nakagi, Toshihiro Ito, Yoshihiko Sugioka, Kazuyo Kitaoka-Higashiguchi, Takahiko Yoshida

    The Australian journal of rural health   21 ( 4 )   225 - 31   2013.8

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    OBJECTIVE: To elucidate the differences in job stress and burnout status of Japanese hospital physicians between large cities, small cities, and towns and villages. DESIGN: Cross-sectional study. SETTING: Postal self-administered questionnaires were distributed to 2937 alumni of Asahikawa Medical University. PARTICIPANTS: Four hundred and twenty-two hospital physicians. MAIN OUTCOME MEASURES: The Brief Job Stress Questionnaire was used to evaluate job demand, job control and social support. The Japanese version of the Maslach Burnout Inventory-General Survey (MBI-GS) was used to evaluate burnout. An analysis of covariance was conducted on the mean scores on the Brief Job Stress Questionnaire and the MBI-GS scales after adjusting for sex, age and specialties. RESULTS: In adjusted analyses, the job demand score was significantly different among physicians in the three areas. In Bonferroni post-hoc tests, scores in large cities was significantly higher than those in small cities and towns and villages. The job control score showed a significant difference and a marginally significant trend, with large cities associated with lower job control. There were significant differences in support from supervisors and that from family/friends, and scores in large cities was significantly higher than those in small cities in the post-hoc test. There was a significant effect on the exhaustion scale of the MBI-GS, with large cities associated with higher exhaustion, and scores in large cities was significantly higher than those in small cities. CONCLUSIONS: Urban hospital physicians had more job demand, less job control and exhaustion caused by burnout, and rural hospital physicians had less social support.

    DOI： 10.1111/ajr.12040

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  • 勤務医のバーンアウトに関連する職業要因

    西條 泰明, 中木 良彦, 伊藤 俊弘, 杉岡 良彦, 岡崎 秀人, 吉田 貴彦, 田村 義之, 千葉 茂, 北岡 和代

    産業衛生学雑誌   53 ( 臨増 )   573 - 573   2011.5

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  • Arsenic methylation capacity and its correlation with skin lesions induced by contaminated drinking water consumption in residents of chronic arsenicosis area Reviewed

    Li, X., Li, B., Xu, Y., Wang, Y., Jin, Y., Itoh, T., Yoshida, T., Sun, G.

    Environmental Toxicology   26 ( 2 )   118 - 123   2011.4

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    DOI： 10.1002/tox.20535

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  • 大学職員の飲酒習慣が睡眠に及ぼす影響について Reviewed

    伊藤俊弘, 吉田貴彦, 中木良彦, 西條泰明, 廣岡憲造, 上林宏次, 岡崎秀人, 稲積圭一, 川西康之, 田村義之, 稲葉央子, 千葉 茂

    北方産業衛生   48   31 - 39   2011.4

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    Authorship：Lead author   Language：Japanese   Publishing type：Research paper (scientific journal)  

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  • 北海の周産期医療における病院アクセスと周産期アウトカム. Reviewed

    西條泰明, 中木良彦, 伊藤俊弘, 杉岡良彦, 吉田貴彦

    厚生の指標   58   1 - 5   2011.4

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  • Effect of Zinc deficiency on the Behavior of Metallothionein-I, II knockout mice. Reviewed

    Toshihiro Itoh, Kunihiko Nakai, Masahiko Satoh, Chieko Satoh, Satomi Kameo, Yoshihiko Nakagi, Yasuaki Saijo, Takahiko Yoshida, Akira Naganuma, Hirohisa Imai, Hiroshi Satoh

    Biomedical Research on Trace Elements   21 ( 4 )   2011.4

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  • Dampness, food habits, and sick building syndrome symptoms in elementary school pupils. International journal

    Yasuaki Saijo, Yoshihiko Nakagi, Toshihiro Ito, Yoshihiko Sugioka, Hitoshi Endo, Takahiko Yoshida

    Environmental health and preventive medicine   15 ( 5 )   276 - 84   2010.9

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    OBJECTIVES: We investigated dampness/mold in schools and dwellings, and food habits and subjective symptoms in elementary school pupils, in order to clarify the effect of dampness and food habits on subjective symptoms in elementary school pupils. METHODS: Questionnaires were used to investigate dampness in classrooms and dwellings in Hokkaido, Japan, and its effect on subjective symptoms in 1,077 pupils in 8 elementary schools. We used a dampness index for both the home and classroom; the index was the sum of the presence of four dampness indicators: (1) visible mold, (2) moldy odor, (3) water leakage, and (4) condensation on windowpanes. The questionnaire also contained queries about food habits, as follows: the frequency of eating breakfast, whether the energy provided by the school lunch was sufficient, and whether eating too many snacks and/or sweets were consumed. Adjusted logistic regression was used to determine whether dampness and food habits were related to the subjective symptoms. RESULTS: In fully adjusted models, the home dampness index was significantly related to cough, general symptoms, and having at least one symptom; the classroom dampness index was significantly related to nasal symptoms. In addition, usually not eating breakfast was significantly related to eye symptoms, and too many snacks and/or sweets was significantly related to eye, nasal, and general symptoms. CONCLUSIONS: Both home and classroom dampness can affect pupils' health. Home dampness, in particular, was significantly related to cough and general symptoms, and classroom dampness was significantly related to nasal symptoms. Furthermore, favorable food habits have a positive effect on pupils' subjective symptoms.

    DOI： 10.1007/s12199-010-0139-0

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  • Association between lifestyle habits and bone mineral density in Japanese juveniles. Reviewed

    Yoshihiko Nakagi, Toshihiro Ito, Kenzo Hirooka, Yasuaki Saijo, Hirohisa Imai, Hidekatsu Takeda, Fujio Kayama, Satoshi Sasaki, Takahiko Yoshida

    Environmental Health Preventive Medicine.   15 ( 4 )   222 - 228   2010.7

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    DOI： 10.1007/s12199-009-0131-8

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  • Relation of dampness to sick building syndrome in Japanese public apartment houses.

    Saijo Y., Nakagi Y., Ito T., Sugioka Y., Endo H., Yoshida T.

    Environ Health Prev Med   14 ( (1) )   26 - 35   2009.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s12199-008-0052-y

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  • Comparative Study of Simple Semiquantitative Dust Mite Allergen Tests.

    Yasuaki Saijo, Yoshihiko Nakagi, Yoshihiko Sugioka, Toshihiro Itoh, Hitoshi Endo, Hikaru Kuroda, Takahiko Yoshida

    Environmental Health Preventive Medicine   12 ( (5) )   187 - 192   2007.4

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  • Chronic exposure to sodium arsenite causes fibrogenic changes in the skin of mice, and short-term exposure may show anti-fibrogenic effects on fibroblast cells.

    Yoshihiko Sugioka, Hitoshi Endo, Yoshihiko Nakagi, Toshihiro Itoh, Yasuaki Saijo, Takahiko Yoshida

    Japanese Journal of Clinical Ecology   16 ( (2) )   117 - 126   2007.4

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  • Prevalence of Burnout among Public Health Nurses in Charge of Mental Health Services and Emergency Care Systems in Japan Reviewed

    Hirohisa IMAI, Hiroyuki NAKAO, Yoshihiko NAKAGI, Satoko NIWATA, Yoshihiko SUGIOKA, Toshihiro ITOH, Takahiko YOSHIDA

    Environmental Health Preventive Medicine   11   286 - 291   2006.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1265/ehpm.11.286

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  • Salivary chromogranin A as a measure of stress response to noise Reviewed

    Masamitsu Miyakawa, Toshihito Matsui, Hiroki Kishikawa, Rumiko Murayama, Iwao Uchiyama, Toshihiro Itoh, Takahiko Yoshida

    Noise and Health   8 ( 32 )   108 - 113   2006

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：NRN Publications  

    DOI： 10.4103/1463-1741.33951

    Scopus

    PubMed

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  • Characteristics of psychiatric hospitals associated with length of stay in Japan. International journal

    Hirohisa Imai, Jun Hosomi, Hiroyuki Nakao, Hiromasa Tsukino, Takahiko Katoh, Toshihiro Itoh, Takahiko Yoshida

    Health policy (Amsterdam, Netherlands)   74 ( 2 )   115 - 21   2005.10

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    OBJECTIVE: Average length of inpatient stay at psychiatric hospitals in Japan has been consistently longer than that in any other developed country, and was 330 days in 1996. Although some reforms have been implemented with the intention of decreasing length of stay (LOS), appreciable reductions have not been achieved. The present study examined hospital characteristics associated with length of stay in regional psychiatric hospitals in Japan, in order to identify variables that might help to reduce LOS. METHOD: This cross-sectional study analysed the complete database of one district in Japan. Analyses were conducted using aggregate data from 24 hospitals. Multiple regression analysis was performed to determine hospital characteristics influencing LOS in psychiatric hospitals. RESULTS: Significant positive associations were identified between LOS and two hospital characteristics: inpatient capacity; proportion of involuntary admissions. Negative associations were observed for three variables: number of outpatients; human resources in terms of healthcare professionals available in each hospital; community activity. Multiple linear regression analysis for the 24 hospitals revealed that number of outpatients and proportion of patients receiving public aid were independently associated with shorter LOS, while proportion of involuntary admissions was independently associated with longer LOS. A negative association between human resources in terms of number of healthcare professionals and LOS was suggested. CONCLUSION: Several hospital characteristics are associated with LOS in psychiatric hospitals. Factors identified in this study offer insights into directions for effective psychiatric health policy to reduce LOS.

    PubMed

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  • Computational dynamics method for evaluating the mobility of charged biomolecules passing through the electrical potential field within the ion selective channel on an excitable membrane. Reviewed

    Hirofumi Hirayama, Toshihiro Itoh, Yoshihiko Nakagi, Takahiko Yoshida

    Artif. Life Robotics   9   144 - 160   2005.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s10015-004-0317-5

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  • Study on the metabolism of arsenic using mouse sliced liver

    NAKAGI Y.

    Sangyo Eiseigaku Zasshi   44   778 - 778   2002

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    Language：Japanese   Publisher：Japan Society for Occupational Health  

    DOI： 10.1539/sangyoeisei.KJ00003948180

    CiNii Books

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  • 6. 室内公共空間における喫煙影響評価の検討 (第63回北方産業衛生学会並びに平成12年度北海道地方会)

    伊藤 俊弘, 松井 利仁, 中木 良彦, 吉田 貴彦

    産業衛生学雑誌   43 ( 2 )   47 - 48   2001

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    Language：Japanese   Publisher：公益社団法人 日本産業衛生学会  

    DOI： 10.1539/sangyoeisei.KJ00002552485

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  • Endogenous zinc release in the hippocampus of the anesthetized rat brain using microdialysis. Reviewed

    T. Itoh, T. Saito

    Trace Elements and Electrolytes   13 ( 4 )   196 - 199   1996.4

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

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  • Dose effects of intratracheally instilled silica dust on plasma trace elements in rats. Reviewed

    T. Saito, S. Han, T. Itoh, S. Watanabe, K. Saito

    Trace Elements and Electrolytes   12 ( 3 )   116 - 118   1995.4

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  • ストレスと血圧および心拍数の周期変動

    神山昭男, 伊藤和弥, 伊藤俊弘, 斎藤健, 斎藤和雄

    Therapeutic Research   13 ( 7 )   35 - 37   1992.4

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

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MISC

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Presentations

  • エコチル調査北海道ユニットセンターにおける妊娠時のシラカンバ特異IgEレベル International conference

    西條 泰明他

    第77回日本公衆衛生学会総会  安村誠司

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    Event date： 2018.10

    Language：Japanese   Presentation type：Poster presentation  

    Venue：ビッグパレットふくしま  

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  • The relationship of shoulder or neck pain and quality of life in patients with neck dissection for head and neck cancer International conference

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    Event date： 2018.6

    Language：Japanese   Presentation type：Oral presentation (general)  

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Works

  • 胎生期における砒素曝露が行動および学習に及ぼす影響

    2002

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Research Projects

  • タウ蛋白質のリン酸化を介したアルツハイマー病の発症に対するエゾウコギの予防効果

    2018.1 - 2019.3

    ㈱サン・クロレラ 

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    アルツハイマー病の主要な発症機構にアミロイドβおよびリン酸化タウ蛋白質が関わっている。一方、エゾウコギは生体に対して抗ストレス作用や抗うつ作用など中枢神経系への効果が確認されており、アルツハイマー病に対しても予防効果が期待されるが、これまでアルツハイマー病に対する研究はほとんど行われていない。本研究は、アルツハイマー病の予防にエゾウコギ（Eleutherococcus senticosus）の関与を検討するために老化促進マウス(Sam P8）及び対照のSam Rマウスに5週齢からウコギ抽出液を添加した飼料を５週間投与した後10週間トレッドミルによる運動を負荷する。その後ウォーターメイズ等を用いた記憶テストを実施する。その後動物を安楽処置によりと殺し直ちに脳海馬および大脳皮質を摘出し、これら組織中タウ蛋白質のリン酸化について解析を行い、エゾウコギの効果を検証する。実験に際し動物の福祉と人道的取り扱いを常に心がける。使用マウスは各10匹（SamP8＋SamR）/施行×2施行を2回実施する予定である（計80匹）。

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  • Study on the effect of arsenic exposure during the embryonic on the behavioof younger generation

    Grant number：14570295  2002.4 - 2004.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    ITOH Toshihiro, SATOH Hiroshi, NAKAGI Yoshihiko, YOSHIDA Takahiko, YAMAUCHI Hiroshi, WATANABE Chiho

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    Grant amount：\3,300,000 （ Direct Cost: \3,300,000 ）

    We investigated the effect of arsenic exposure from the before embryonic on the development of central nervous system of the child. C57B1/6 mouse were exposed trivalent arsenite(As (III)) and pentavalent arsenate(As(v)) in low-level(10ppm) or high-level(100ppm) in drinking-water, and the arsenic exposure have continued to 3 generations. The behavioral development test in the early stage of growth, and Open-field test and T-type water maze test after the growth were carried out the animals in 3 generation(F2). After the behavioral tests, immunological function was tested using lymphocyte of the lien.
    We observed different effect of long-term inorganic arsenic exposure for the development of postnatal behavior between As(III) and As(V). Little effects of the As exposure on the behavioral development test of the mouse were observed in the As(III) animals, but delay of development of the reflection and motor function was observed in the As(V) animals. In addition, some effects on the emotional reaction after the growth were also observed in the As exposed animals. It is not known the reason that we obtained different results for their behavior between long term exposure of As(III) and As(V) animals. But, it is necessary to clarify the mechanism for these causes in future.

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  • 慢性砒素中毒における行動毒性に関する研究

    2001 - 2002

    科学研究費補助金 

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    Grant type：Competitive

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  • 中枢の神経伝達機構における細胞内亜鉛輸送蛋白質の発現と脳機能への役割に関する研究

    Grant number：11770178  1999.4 - 2001.3

    日本学術振興会  科学研究費補助金  奨励研究(A)

    伊藤 俊弘

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    Grant amount：\2,100,000 （ Direct Cost: \2,100,000 ）

    脳内における亜鉛の生理的役割の詳細な解明のために亜鉛トランスポーターの基本的性質を遺伝子レベルで解明することを目的として、ラット脳内のZnT3およびZnT4の発現が亜鉛欠乏によりどのような影響を受けるのかを実験的に確認したが、亜鉛欠乏による明らかな影響は確認されなかった。

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  • ストレスに対する亜鉛および一酸化窒素の中枢神経系における役割に関する研究

    Grant number：09770231  1997.4 - 1999.3

    日本学術振興会  科学研究費補助金  奨励研究(A)

    伊藤 俊弘

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    Grant amount：\1,900,000 （ Direct Cost: \1,900,000 ）

    中枢神経系ストレスモデル動物として競争的摂食ストレスを負荷したラットを作成し、ストレス反応に対する亜鉛および一酸化窒素の役割を検討するために、ラット脳海馬部位での一酸化窒素(NO)産生に対する亜鉛の影響をマイクロダイアリシス法により検討した。その結果、脳海馬に存在する遊離の亜鉛がNO産生を誘導し、ストレス抵抗性を高めることが示唆された。

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  • ストレスによる亜鉛の神経伝達系に対する役割に関する研究

    Grant number：08770246  1996.4 - 1997.3

    日本学術振興会  科学研究費補助金  奨励研究(A)

    伊藤 俊弘

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    Grant amount：\1,100,000 （ Direct Cost: \1,100,000 ）

    中枢神経系ストレスモデル動物として競争的摂食ストレスを負荷したラットを作成し、ストレス反応に対する亜鉛の役割を検討するために、ラット脳海馬部位での亜鉛の放出についてマイクロダイアリシス法により検討した。その結果、脳海馬に存在する遊離の亜鉛が神経の刺激により神経終末に放出されることを示唆する結果が得られた。

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  • Study on the role of Trace Elements under Stress

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    Grant type：Competitive

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  • Study on the effect of heavy metals for hearling function and central nervous system.

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    Grant type：Competitive

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  • Study on the role of essential Trace elements in brain

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    Grant type：Competitive

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  • ストレスにおける生体内微量元素の役割に関する研究

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    Grant type：Competitive

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  • Research on the mechanisms of environmental materials for the appearance of behavioral toxicity

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    Grant type：Competitive

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  • 環境中物質の行動毒性発現機序に関する研究

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    Grant type：Competitive

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  • 脳内の必須微量元素の役割に関する研究

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    Grant type：Competitive

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Social Activities

  • 派遣講座 末広公民館

    2019.7

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  • あさひかわオープンカレッジ

    2018.10

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    講演タイトル「『これからの旭川 これからの旭川 』における健康長寿を考え」 における健康長寿を考え」 における健康長寿を考える」

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  • 派遣講座 東光公民館

    2018.6

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    講演タイトル「根拠に基づいた健康づくりをしよう」
    東光公民館

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  • JICA 地域保健担当官のための保健行政研修

    2017.6

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    環境保健行政の実務（上下水処理、廃棄物処理）

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  • 永山公民館百寿大学 派遣講座

    2010.12

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  • 放送大学 非常勤講師

    2010.11

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    生活習慣病予防と抗加齢医学概論

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  • 北海道立紋別高等看護学院非常勤講師

    2010.9 - 2010.12

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    公衆衛生学

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  • 労働衛生週間における労働衛生実務研修会

    2010.9

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  • 旭川ウェルビーイング・コンソーシアム連携公開講座

    2010.9

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  • 旭川市医師会看護専門学校非常勤講師

    2010.8 - 2010.12

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    公衆衛生学

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  • 北海道立旭川高等看護学院非常勤講師

    2010.5 - 2010.8

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    保健福祉政策論（環境保健学）

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  • 旭川厚生看護専門学校 非常勤講師

    2010.5 - 2010.7

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    公衆衛生学

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  • 北海道医療技術専門学校 非常勤講師

    2010.4

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    公衆衛生学

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  • 健康保養ネットワーク講演

    2010.1

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  • 神楽公民館百寿大学 派遣講座

    2009.11

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  • 日本赤十字北海道看護大学非常勤講師

    2009.10 - 2009.12

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    公衆衛生学

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  • 富良野市ノルディックウォーキング講演

    2009.10

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  • 北海道立紋別高等看護学院非常勤講師

    2009.9 - 2009.12

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    公衆衛生学

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  • 東光百寿大学 派遣講座

    2009.9

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  • 鷹栖公民館百寿大学 派遣講座

    2009.9

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  • 旭川市医師会看護専門学校非常勤講師

    2009.8 - 2009.12

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    公衆衛生学

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  • 北海道立旭川高等看護学院非常勤講師

    2009.5 - 2009.8

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    保健福祉政策論（環境保健学）

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  • 旭川厚生看護専門学校 非常勤講師

    2009.5 - 2009.7

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    公衆衛生学

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  • 北海道医療技術専門学校 非常勤講師

    2009.4 - 2010.3

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    公衆衛生学

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  • 健康保養ネットワーク講演

    2009.1

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  • 北海道地区国立学校等安全管理協議会

    2008.11

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  • 旭川市図書館 派遣講座

    2008.11

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  • 日本赤十字北海道看護大学非常勤講師

    2008.10 - 2008.12

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    公衆衛生学

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  • 北海道立紋別高等看護学院非常勤講師

    2008.9 - 2008.12

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    公衆衛生学

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  • 旭川市医師会看護専門学校非常勤講師

    2008.8 - 2008.12

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    公衆衛生学

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  • 旭川中央公民館百寿大学 派遣講座

    2008.7

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  • 北海道立旭川高等看護学院非常勤講師

    2008.5 - 2008.8

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    地域管理論（環境保健）

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  • 旭川厚生看護専門学校 非常勤講師

    2008.5 - 2008.7

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    公衆衛生学

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  • 東神楽町生活習慣病講演会 派遣講座

    2008.3

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  • 西神楽百寿大学 派遣講座

    2007.12

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  • 富良野市市民研修会 派遣講座

    2007.11

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  • 滝川市国保温泉ゆったり教室

    2007.10

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  • 北海道立紋別高等看護学院非常勤講師

    2007.9 - 2007.12

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    公衆衛生学

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  • 旭川市医師会看護専門学校非常勤講師

    2007.8 - 2007.12

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    公衆衛生学

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  • 旭川市百寿大学 派遣講座

    2007.7

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  • 日本赤十字北海道看護大学非常勤講師

    2007.5 - 2007.12

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    疫学、公衆衛生学

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  • 北都保健福祉専門学校 非常勤講師

    2007.5 - 2007.9

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    統計学

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  • 北海道立旭川高等看護学院非常勤講師

    2007.5 - 2007.8

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    保健管理論（環境保健）

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  • 雄武町町民大学 派遣講座

    2006.11

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  • 北海道立紋別高等看護学院非常勤講師

    2006.9 - 2006.12

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    公衆衛生学

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  • 旭川市医師会看護専門学校非常勤講師

    2006.8 - 2006.12

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    公衆衛生学

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  • 派遣講座

    2006.7

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  • 旭川市北星公民館女性大学 派遣講座

    2006.6

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  • 日本赤十字北海道看護大学非常勤講師

    2006.5 - 2006.12

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    疫学、公衆衛生学

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  • 北都保健福祉専門学校 非常勤講師

    2006.5 - 2006.9

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    統計学

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  • 北海道立旭川高等看護学院非常勤講師

    2006.5 - 2006.8

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    保健管理論（環境保健）

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  • 旭川市女性大学 派遣講座

    2006.5

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  • 美瑛町 派遣講座

    2006.3

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  • 富良野市 派遣講座

    2006.2

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  • 北海道立紋別高等看護学院非常勤講師

    2005.9 - 2005.12

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    公衆衛生学

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  • 旭川市医師会看護専門学校非常勤講師

    2005.8 - 2005.12

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    公衆衛生学

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  • 日本赤十字北海道看護大学非常勤講師

    2005.5 - 2005.12

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    疫学、公衆衛生学

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  • 北都保健福祉専門学校 非常勤講師

    2005.5 - 2005.9

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    統計学

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  • 旭川厚生看護専門学校 非常勤講師

    2005.5 - 2005.7

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    公衆衛生学

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  • 愛別町子育て研修会

    2004.11

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  • 北海道立紋別高等看護学院非常勤講師

    2004.9 - 2004.12

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    公衆衛生学

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  • 旭川市医師会看護専門学校非常勤講師

    2004.8 - 2004.12

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    公衆衛生学

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  • 日本赤十字北海道看護大学非常勤講師

    2004.5 - 2004.12

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    疫学、公衆衛生学

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  • 北都保健福祉専門学校 非常勤講師

    2004.5 - 2004.9

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    統計学

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