Updated on 2025/08/08

写真a

 
TAKIYAMA Yumi
 
Organization
School of Medicine Medical Course Clinical Medicine Internal Medicine [Division of Endocrine,Metabolic, Collagen disease ]
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Degree

  • Doctor (Medicine) ( 1990.3   Asahikawa Medical College )

Research Interests

  • Diabetic Kidney Disease

  • Diabetes / Endocrinology

Research Areas

  • Life Science / Metabolism and endocrinology

  • Life Science / Nephrology

Education

  • 旭川医科大学 大学院 博士課程

    1986.4 - 1990.3

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  • Asahikawa Medical College   School of Medicine

    1980.4 - 1986.3

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    Country: Japan

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Research History

  • Asahikawa Medical College   Associate Professor

    2017.10

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  • Asahikawa Medical College   Research Associate Professor

    2011.10 - 2017.9

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  • Asahikawa Medical College   Research Assistant Professor

    2009.4 - 2011.9

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  • 旭川医科大学医学部付属病院   医員

    2004.4 - 2009.3

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  • 医療法人社団 滝山内科医院   副院長

    1998.4 - 2004.3

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  • 旭川医科大学医学部付属病院   医員

    1996.7 - 1998.3

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  • アメリカ合衆国ジョンス・ホプキンス大学 Post-doctral fellow

    1995.6 - 1997.6

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  • 旭川医科大学医学部付属病院 医員

    1993.11 - 1995.5

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  • 旭川医科大学医学部付属病院 医員

    1992.4 - 1993.3

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  • 旭川赤十字病院 内科

    1990.4 - 1991.3

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  • Tokyo Women's Medical University   Graduate student(doctorate program)

    1987.5 - 1989.3

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Professional Memberships

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Committee Memberships

  •   日本糖尿病学::「Diabetology International」編集委員会  

    2022.5   

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Studying abroad experiences

  • 1995.5 - 1996.7   Johns Hopkins University   Post-doctral fellowship

Papers

  • Efficacy of Alogliptin/Metformin Fixed-Dose Combination Tablets and Vildagliptin/Metformin Fixed-Dose Combination Tablets on Glycemic Control in Real-World Clinical Practice for the Patients with Type 2 Diabetes: A Multicenter, Open-Label, Randomized, Parallel Group, Comparative Trial. International journal

    Tomoe Abe, Yasutaka Takeda, Ichiro Sakuma, Mizuho Okada, Ayaka Kurigaki, Ryoichi Bessho, Mao Sato, Hiroya Kitsunai, Yumi Takiyama, Masaru Sakurai

    Metabolic syndrome and related disorders   22 ( 9 )   651 - 660   2024.11

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    Background: This study was aimed to compare the efficacy of two combination tablets of dipeptidyl peptidase-4 (DPP-4) inhibitors and metformin with different dosages, alogliptin/metformin (AM) and vildagliptin/metformin (VM), on glycemic control in patients with type 2 diabetes (T2D). Methods: This was a prospective, multicenter, open-label, randomized, parallel group, comparative trial. After a run-in period of treatment with metformin alone, a total of 59 Japanese outpatients with T2D, aged 20-79 years with glycated hemoglobin (HbA1c) levels of 6.5%-10% were randomly assigned to 12-week AM treatment, alogliptin 25 mg/metformin 500 mg combination tablet orally once a day, or VM treatment, vildagliptin 50 mg/metformin 250 mg combination tablet orally twice a day. The primary endpoints were the changes in HbA1c and fasting plasma glucose (FPG) levels from baseline to week 12 between the two groups. Blinded intermittently scanned continuous glucose monitoring (isCGM) was performed between weeks 10 and 12. The incidence of adverse events during the study was also evaluated. Results: In all, 52 participants were analyzed. Significant decreases in HbA1c and FPG levels from baseline to week 12 were observed in both treatment groups. However, there were no significant differences between the AM and VM groups in the change in HbA1c level (-0.3% and -0.4%, P = 0.309) or the FPG level (-9.0 and -15.0 mg/dL, P = 0.789). The isCGM revealed that both treatments achieved the recommended glycemic target range. No adverse events, such as severe hypoglycemia, were observed in either group. Conclusions: We concluded that there were no significant differences in the efficacy of two combination tablets of DPP-4 inhibitors and metformin with different dosages on glycemic control in patients with T2D.

    DOI: 10.1089/met.2024.0127

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  • A natural Nrf2 activator glucoraphanin improves hepatic steatosis in high-fat diet-induced obese male mice associated with AMPK activation

    Suratsawadee Promsuwan, Kazuki Sawamoto, Liang Xu, Mayumi Nagashimada, Naoto Nagata, Yumi Takiyama

    Diabetology International   2023.8

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    Authorship:Corresponding author   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    DOI: 10.1007/s13340-023-00658-6

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    Other Link: https://link.springer.com/article/10.1007/s13340-023-00658-6/fulltext.html

  • A maternal high-fat diet induces fetal origins of NASH-HCC in mice. International journal

    Takao Takiyama, Toshihiro Sera, Masanori Nakamura, Masato Hoshino, Kentaro Uesugi, Shin-Ichi Horike, Makiko Meguro-Horike, Ryoichi Bessho, Yuri Takiyama, Hiroya Kitsunai, Yasutaka Takeda, Kazuki Sawamoto, Naoto Yagi, Yuji Nishikawa, Yumi Takiyama

    Scientific reports   12 ( 1 )   13136 - 13136   2022.7

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    Maternal overnutrition affects offspring susceptibility to nonalcoholic steatohepatitis (NASH). Male offspring from high-fat diet (HFD)-fed dams developed a severe form of NASH, leading to highly vascular tumor formation. The cancer/testis antigen HORMA domain containing protein 1 (HORMAD1), one of 146 upregulated differentially expressed genes in fetal livers from HFD-fed dams, was overexpressed with hypoxia-inducible factor 1 alpha (HIF-1alpha) in hepatoblasts and in NASH-based hepatocellular carcinoma (HCC) in offspring from HFD-fed dams at 15 weeks old. Hypoxia substantially increased Hormad1 expression in primary mouse hepatocytes. Despite the presence of three putative hypoxia response elements within the mouse Hormad1 gene, the Hif-1alpha siRNA only slightly decreased hypoxia-induced Hormad1 mRNA expression. In contrast, N-acetylcysteine, but not rotenone, inhibited hypoxia-induced Hormad1 expression, indicating its dependency on nonmitochondrial reactive oxygen species production. Synchrotron-based phase-contrast micro-CT of the fetuses from HFD-fed dams showed significant enlargement of the liver accompanied by a consistent size of the umbilical vein, which may cause hypoxia in the fetal liver. Based on these findings, a maternal HFD induces fetal origins of NASH/HCC via hypoxia, and HORMAD1 is a potential therapeutic target for NASH/HCC.

    DOI: 10.1038/s41598-022-17501-8

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  • A case of insulinoma diagnosed postpartum with hypoglycemic symptoms that were masked during pregnancy. Reviewed International journal

    Tomoe Abe, Yasutaka Takeda, Takao Takiyama, Ayaka Sasaki, Ryoichi Bessho, Mao Sato, Hiroya Kitsunai, Hidemitsu Sakagami, Atsuko Abiko, Koji Imai, Sayaka Yuzawa, Mishie Tanino, Yumi Takiyama

    Clinical case reports   9 ( 4 )   1991 - 1998   2021.2

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    The diagnosis of insulinoma in perinatal women can be difficult, as hypoglycemic symptoms may be masked by pregnancy-associated insulin resistance. In addition, when multiple insulinomas are observed, it is necessary to consider the possibility not only of MEN1, but also of insulinomatosis.

    DOI: 10.1002/ccr3.3924

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  • Hypoxia-inducible factor-1α is the therapeutic target of the SGLT2 inhibitor for diabetic nephropathy. International journal

    Ryoichi Bessho, Yumi Takiyama, Takao Takiyama, Hiroya Kitsunai, Yasutaka Takeda, Hidemitsu Sakagami, Tsuguhito Ota

    Scientific reports   9 ( 1 )   14754 - 14754   2019.10

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    Previous studies have demonstrated intrarenal hypoxia in patients with diabetes. Hypoxia-inducible factor (HIF)-1 plays an important role in hypoxia-induced tubulointerstitial fibrosis. Recent clinical trials have confirmed the renoprotective action of SGLT2 inhibitors in diabetic nephropathy. We explored the effects of an SGLT2 inhibitor, luseogliflozin on HIF-1α expression in human renal proximal tubular epithelial cells (HRPTECs). Luseogliflozin significantly inhibited hypoxia-induced HIF-1α protein expression in HRPTECs. In addition, luseogliflozin inhibited hypoxia-induced the expression of the HIF-1α target genes PAI-1, VEGF, GLUT1, HK2 and PKM. Although luseogliflozin increased phosphorylated-AMP-activated protein kinase α (p-AMPKα) levels, the AMPK activator AICAR did not changed hypoxia-induced HIF-1α expression. Luseogliflozin suppressed the oxygen consumption rate in HRPTECs, and subsequently decreased hypoxia-sensitive dye, pimonidazole staining under hypoxia, suggesting that luseogliflozin promoted the degradation of HIF-1α protein by redistribution of intracellular oxygen. To confirm the inhibitory effect of luseogliflozin on hypoxia-induced HIF-1α protein in vivo, we treated male diabetic db/db mice with luseogliflozin for 8 to 16 weeks. Luseogliflozin attenuated cortical tubular HIF-1α expression, tubular injury and interstitial fibronectin in db/db mice. Together, luseogliflozin inhibits hypoxia-induced HIF-1α accumulation by suppressing mitochondrial oxygen consumption. The SGLT2 inhibitors may protect diabetic kidneys by therapeutically targeting HIF-1α protein.

    DOI: 10.1038/s41598-019-51343-1

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  • Increment of plasma glucose by exogenous glucagon is associated with present and future renal function in type 2 diabetes:a retrospective study from glucagon stimulation test. Reviewed International journal

    Yasutaka Takeda, Yukihiro Fujita, Ryoichi Bessho, Mao Sato, Tomoe Abe, Tsuyoshi Yanagimachi, Hidemitsu Sakagami, Atsuko Abiko, Yumi Takiyama, Tsuguhito Ota, Masakazu Haneda

    BMC endocrine disorders   19 ( 1 )   99 - 99   2019.10

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    BACKGROUND: Glucagon stimulation test (GST) is often employed to assess the insulin reserve of the pancreatic beta cells in diabetic subjects. The clinical significance of the increment of plasma glucose (Δglucose) by exogenous glucagon during GST has not been elucidated. We investigated the relationship between Δglucose and clinical parameters including the liver and renal function in type 2 diabetic subjects, since we hypothesized that Δglucose is associated with the liver and renal function reflecting the capacity for gluconeogenesis in the organs. METHODS: A total of 209 subjects with type 2 diabetes who underwent GST during admission were included in this cross-sectional study. We defined the difference between plasma glucose at fasting and 6 min after intravenous injection of 1 mg glucagon as Δglucose. We assessed correlations between Δglucose and clinical parameters such as diabetic duration, BMI, HbA1c, beta cell function, serum free fatty acids (FFA) which is known to stimulate gluconeogenesis, liver function, the indices of liver function, renal function, and urinary albumin excretion (UAE). RESULTS: In correlation analysis, Δglucose positively correlated to FFA and estimated glomerular filtration rate (eGFR), but inversely to serum creatinine and cystatin C, although Δglucose showed no correlation with both liver function and the indices of residual liver function. Multiple regression analysis revealed that Δglucose was an independent determinant for the eGFR after 1 year, equally BMI, HbA1c, serum lipids, and UAE, which are known as the predictors for the development of chronic kidney disease. CONCLUSION: Our results suggest that Δglucose during GST might be related to gluconeogenesis in the kidney and could be the determinant of future renal function in type 2 diabetes.

    DOI: 10.1186/s12902-019-0428-6

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  • 臨床経過、関連合併症が著明に異なるミトコンドリア糖尿病の同胞例

    阿部 智絵, 竹田 安孝, 別所 瞭一, 酒井 健太郎, 中村 知伸, 柳町 剛司, 坂上 英充, 藤田 征弘, 安孫子 亜津子, 滝山 由美, 太田 嗣人

    糖尿病   62 ( 3 )   162 - 169   2019.3

  • 妊娠中の明らかな糖尿病の診断を契機に副腎性Cushing症候群の診断に至った1例

    竹田 安孝, 阿部 智絵, 安孫子 亜津子, 別所 瞭一, 酒井 健太郎, 中村 知伸, 柳町 剛司, 坂上 英充, 藤田 征弘, 滝山 由美, 上田 寛人, 千石 一雄, 太田 嗣人

    糖尿病と妊娠   19 ( 1 )   48 - 53   2019.3

  • Two sibling cases of mitochondrial diabetes mellitus presented with different clinical courses and related complications

    Tomoe Abe, Yasutaka Takeda, Ryoichi Bessho, Kentaro Sakai, Tomonobu Nakamura, Tsuyoshi Yanagimachi, Hidemitsu Sakagami, Yukihiro Fujita, Atsuko Abiko, Yumi Takiyama, Tsuguhito Ota

    Journal of the Japan Diabetes Society   62 ( 3 )   162 - 169   2019

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    DOI: 10.11213/tonyobyo.62.162

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  • Impacts of Diabetes and an SGLT2 Inhibitor on the Glomerular Number and Volume in db/db Mice, as Estimated by Synchrotron Radiation Micro-CT at SPring-8. Reviewed International journal

    Yumi Takiyama, Yumi Takiyama'Correspondence information aboutYumi Takiyama, Toshihiro Sera, Masanori Nakamura, Kanaki Ishizeki, Yasuaki Saijo, Tsuyoshi Yanagimachi, Manami Maeda, Ryoichi Bessho, Takao Takiyama, Hiroya Kitsunai, Hidemitsu Sakagami, Daisuke Fujishiro, Yukihiro Fujita, Yuichi Makino, Atsuko Abiko, Masato Hoshino, Kentaro Uesugi, Naoto Yagi, Tsuguhito Ota, Masakazu Haneda

    EBioMedicine   36   329 - 346   2018.10

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    BACKGROUND: Recent large-scale clinical studies demonstrate that sodium-glucose cotransporter 2 (SGLT2) inhibitors protect the diabetic kidney. However, clinical and animal studies have not shown the changes of the total glomeruli in the whole kidney treated with SGLT2 inhibitors. METHODS: We performed computed tomography (CT) imaging on mice using synchrotron radiation to investigate the impact of luseogliflozin, a SGLT2 inhibitor, on the number and volume of glomeruli in the whole kidney. FINDINGS: We did not observe a significant difference in the total glomerular number (Nglom) among mice. Luseogliflozin redistributed the number of glomeruli in different regions, accompanied by the normalization of diabetes-augmented renal volume (Vkidney). Diabetic db/db mice had a larger glomerular volume in the mid-cortex than did control db/m mice, and luseogliflozin increased the glomerular volume in all renal cortical zones of the whole kidney in db/db mice. According to the multivariate regression analysis, hemoglobin A1c level was the most relevant determinant of Vkidney, not Nglom or mean glomerular volume (Vglom), indicating that hyperglycemia induced renal (tubular) hypertrophy, but not glomerular enlargement. Luseogliflozin increased hypoxia in the juxtamedullary region, sustained upregulated renal renin expression and plasma renin activity, and failed to decrease albuminuria by downregulating megalin in db/db mice. INTERPRETATION: Based on our findings, SGLT2 inhibitors may alter glomerular distribution and size in addition to their glucose-lowering effects, presumably by affecting oxygen metabolism and humoral factors. FUND: Funding for this research was provided by The Japan Society for the Promotion of Science, the Japan Diabetes Foundation, and Asahikawa Medical University.

    File: PIIS2352396418304079.pdf

    DOI: 10.1016/j.ebiom.2018.09.048

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  • Dipeptidyl peptidase-4 inhibitor treatment induces a greater increase in plasma levels of bioactive GIP than GLP-1 in non-diabetic subjects Reviewed

    Tsuyoshi Yanagimachi, Yukihiro Fujita, Yasutaka Takeda, Jun Honjo, Hidemitsu Sakagami, Hiroya Kitsunai, Yumi Takiyama, Atsuko Abiko, Yuichi Makino, Timothy J. Kieffer, Masakazu Haneda

    MOLECULAR METABOLISM   6 ( 2 )   226 - 231   2017.2

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    DOI: 10.1016/j.molmet.2016.12.009

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  • Sodium-Glucose Cotransporter 2 Inhibitor and a Low Carbohydrate Diet Affect Gluconeogenesis and Glycogen Content Differently in the Kidney and the Liver of Non-Diabetic Mice Reviewed

    Kuralay Atageldiyeva, Yukihiro Fujita, Tsuyoshi Yanagimachi, Katsutoshi Mizumoto, Yasutaka Takeda, Jun Honjo, Yumi Takiyama, Atsuko Abiko, Yuichi Makino, Masakazu Haneda

    PLOS ONE   11 ( 6 )   e0157672.   2016.6

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    DOI: 10.1371/journal.pone.0157672

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  • Alternative form of glucose-dependent insulinotropic polypepide and its physiology Reviewed

    Yukihiro Fujita, Tsuyoshi Yanagimachi, Yasutaka Takeda, Jun Honjo, Yumi Takiyama, Atsuko Abiko, Yuichi Makino, Masakazu Haneda

    JOURNAL OF DIABETES INVESTIGATION   7   33 - 37   2016.4

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    DOI: 10.1111/jdi.12445

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  • Role of IGFBP7 in Diabetic Nephropathy: TGF-beta 1 Induces IGFBP7 via Smad2/4 in Human Renal Proximal Tubular Epithelial Cells Reviewed

    Jun Watanabe, Yumi Takiyama, Jun Honjyo, Yuichi Makino, Yukihiro Fujita, Masatoshi Tateno, Masakazu Haneda

    PLOS ONE   11 ( 3 )   e0150897.   2016.3

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    DOI: 10.1371/journal.pone.0150897

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  • Pancreatic glucose-dependent insulinotropic polypeptide (GIP) (1-30) expression is upregulated in diabetes and PEGylated GIP(1-30) can suppress the progression of low-dose-STZ-induced hyperglycaemia in mice Reviewed

    Tsuyoshi Yanagimachi, Yukihiro Fujita, Yasutaka Takeda, Jun Honjo, Kuralay K. Atageldiyeva, Yumi Takiyama, Atsuko Abiko, Yuichi Makino, Timothy J. Kieffer, Masakazu Haneda

    DIABETOLOGIA   59 ( 3 )   533 - 541   2016.3

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    DOI: 10.1007/s00125-015-3842-y

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  • Implication of intracellular localization of transcriptional repressor PLZF in thyroid neoplasms Reviewed

    Kazuhiko Matsuzawa, Shoichiro Izawa, Tsuyoshi Ohkura, Hiroko Ohkura, Kiyosuke Ishiguro, Akio Yoshida, Yumi Takiyama, Masakazu Haneda, Chiaki Shigemasa, Kazuhiro Yamamoto, Shin-ichi Taniguchi

    BMC ENDOCRINE DISORDERS   14 ( 52 )   E1065 - E1076   2014

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    DOI: 10.1186/1472-6823-14-52

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  • Hypoxia in Diabetic Kidneys Invited Reviewed

    Yumi Takiyama, Masakazu Haneda

    BIOMED RESEARCH INTERNATIONAL   2014   837421.   2014

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    DOI: 10.1155/2014/837421

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  • 造影剤腎症におけるメトホルミン効果についての検討 Invited

    滝山 由美

    旭川医科大学研究フォーラム   13   61 - 62   2013.2

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    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (bulletin of university, research institution)  

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  • Reduction of both beta cell death and alpha cell proliferation by dipeptidyl peptidase-4 inhibition in a streptozotocin-induced model of diabetes in mice Reviewed

    Y. Takeda, Y. Fujita, J. Honjo, T. Yanagimachi, H. Sakagami, Y. Takiyama, Y. Makino, A. Abiko, T. J. Kieffer, M. Haneda

    DIABETOLOGIA   55 ( 2 )   404 - 412   2012.2

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    DOI: 10.1007/s00125-011-2365-4

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  • 右副腎腺腫合併のpreclinical Cushin's diseaseの一例 Invited

    滝山 由美, 安孫子 亜津子, 藤田 征弘, 羽田 勝計

    日本内分泌学会雑誌   87 ( Suppl. )   28 - 31   2011.6

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  • Tubular Injury in a Rat Model of Type 2 Diabetes Is Prevented by Metformin A Possible Role of HIF-1 alpha Expression and Oxygen Metabolism Reviewed

    Yumi Takiyama, Tatsuo Harumi, Jun Watanabe, Yukihiro Fujita, Jun Honjo, Norihiko Shimizu, Yuichi Makino, Masakazu Haneda

    DIABETES   60 ( 3 )   981 - 992   2011.3

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    DOI: 10.2337/db10-0655

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  • A Drug for Diabetic Multiple Organ Complications Invited

    滝山 由美

    旭川医科大学研究フォーラム   11   61 - 63   2011.2

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  • 右副腎腺腫合併のpreclinical Cushing's diseaseの一例

    滝山 由美, 安孫子 亜津子, 藤田 征弘, 羽田 勝計

    日本内分泌学会雑誌   86 ( 3 )   713 - 713   2010.12

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  • Upregulated IL-18 expression in type 2 diabetic subjects with nephropathy: TGF-beta(1) enhanced IL-18 expression in human renal proximal tubular epithelial cells Reviewed

    Kazunari Miyauchi, Yumi Takiyama, Jun Honjyo, Masatoshi Tateno, Masakazu Haneda

    DIABETES RESEARCH AND CLINICAL PRACTICE   83 ( 2 )   190 - 199   2009.2

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    DOI: 10.1016/j.diabres.2008.11.018

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  • メトホルミンの糖尿病性腎症治療薬としての可能性 Invited

    滝山 由美, 羽田 勝計

    糖尿病合併症   22 ( 2 )   178 - 180   2008.8

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  • 糖尿病性腎症進展予防に対する治療戦略標的としてのInterleukin-18(IL-18) Invited

    滝山 由美, 羽田 勝計

    旭川医科大学研究フォーラム   8 ( 1 )   55 - 56   2007.12

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  • The role of CCL22/macrophage-derived chemokine in allergic rhinitis Reviewed

    Mitsuru Yanai, Keisuke Sato, Naoko Aoki, Yumi Takiyama, Kensuke Oikawa, Hiroya Kobayashi, Shoji Kimura, Yasuaki Harabuchi, Masatoshi Tateno

    CLINICAL IMMUNOLOGY   125 ( 3 )   291 - 298   2007.4

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    DOI: 10.1016/j.clim.2007.08.002

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  • Remission of nephropathy due to multifactorial treatment in a patient with long-standing diabetes of over 30 years' duration

    Atsuko Abiko, Tsubasa Isoe, Kazunari Miyauchi, Jun Honjo, Seiji Uebori, Yumi Takiyama, Hiroshi Itoh, Naoyuki Hasebe, Masakazu Haneda

    Journal of the Japan Diabetes Society   50 ( 3 )   197 - 202   2007

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  • Decreased expression of retinoid X receptor isoforms in human thyroid carcinomas Reviewed

    Y Takiyama, N Miyokawa, A Sugawara, S Kato, K Ito, K Sato, K Oikawa, H Kobayashi, S Kimura, M Tateno

    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM   89 ( 11 )   5851 - 5861   2004.11

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1210/jc.2003-032036

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  • Neuronal calcium sensor protein visinin-like protein-3 interacts with microsomal cytochrome b(5) in a Ca2+-dependent manner Reviewed

    K Oikawa, S Kimura, N Aoki, Y Atsuta, Y Takiyama, T Nagato, M Yanai, H Kobayashi, K Sato, T Sasajima, M Tateno

    JOURNAL OF BIOLOGICAL CHEMISTRY   279 ( 15 )   15142 - 15152   2004.4

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    DOI: 10.1074/jbc.M312766200

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  • Modulation of hepatic granulomatous responses by transgene expression of DAP12 or TREM-1-lg molecules Reviewed

    H Nochi, N Aoki, K Oikawa, M Yanai, Y Takiyama, Y Atsuta, H Kobayashi, K Sato, M Tateno, T Matsuno, M Katagiri, Z Xing, S Kimura

    AMERICAN JOURNAL OF PATHOLOGY   62 ( 4 )   1191 - 1201   2003

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    DOI: 10.1016/S0002-9440(10)63915-6

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  • Thyroid-stimulating hormone induces interleukin-18 gene expression in FRTL-5 cells: Immunohistochemical detection of interleukin-18 in autoimmune thyroid disease Reviewed

    Y Takiyama, N Miyokawa, Y Tokusashi, K Ito, S Kato, S Kimura, K Sato, M Katagiri

    THYROID   12 ( 11 )   935 - 943   2002.11

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  • The role of the DAP12 signal in mouse myeloid differentiation Reviewed

    N Aoki, S Kimura, Y Takiyama, Y Atsuta, A Abe, K Sato, M Katagiri

    JOURNAL OF IMMUNOLOGY   165 ( 7 )   3790 - 3796   2000

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  • Polymerase chain reaction-based microsatellite polymorphism analysis of follicular and Hurthle cell neoplasms of the thyroid Reviewed

    DL Segev, M Saji, GS Phillips, WH Westra, Y Takiyama, S Piantadosi, RC Smallridge, RH Nishiyama, R Udelsman, MA Zeiger

    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM   83 ( 6 )   2036 - 2042   1998

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    DOI: 10.1210/jc.83.6.2036

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  • Genotype-phenotype correlation of patients with multiple endocrine neoplasia type 2 in Japan. Reviewed

    Egawa S., Futami H., Takasaki K., Iihara M., Okamoto T., Kanbe M., Ohi T., Saio Y., Miyauchi A., Takiyama Y., Koga M., Miyanaga K., Inoue K., Mitsuyama S., Nomura Y., Takei H., Mugiya S., Ishida O., Zeze F., Shakutsui S., Inoue H., Oya H., Yoshimura A., Ishizuka S., Yamaguchi K.

    JAPANESE JOURNAL OF CLINICAL ONCOLOGY   28   590 - 596   1998

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    DOI: 10.1093/jjco/28.10.590

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  • Polymerase chain reaction-based microsatellite analysis of fine-needle aspirations from Hurthle cell neoplasms Reviewed

    Y Takiyama, M Saji, DP Clark, GS Phillips, DL Segev, RC Smallridge, WH Westra, R Udelsman, MA Zeiger

    THYROID   7 ( 6 )   853 - 857   1997.12

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  • Thyroid-specific expression of cholera toxin A1 subunit causes thyroid hyperplasia and hyperthyroidism in transgenic mice Reviewed

    MA Zeiger, M Saji, Y Gusev, WH Westra, Y Takiyama, WC Dooley, LD Kohn, MA Levine

    ENDOCRINOLOGY   138 ( 8 )   3133 - 3140   1997.8

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    DOI: 10.1210/en.138.8.3133

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  • Adenoviral infection of thyroid cells: A rationale for gene therapy for metastatic thyroid carcinoma Reviewed

    MA Zeiger, Y Takiyama, JO Bishop, AR Ellison, M Saji, MA Levine

    SURGERY   120 ( 6 )   921 - 925   1996.12

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  • Effects of bile acids on iodide uptake and deoxyribonucleic acid synthesis in porcine thyroid cells in primary culture Reviewed

    R Kanri, Y Takiyama, Makino, I

    THYROID   6 ( 5 )   467 - 474   1996.10

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  • THE EFFECTS OF HYDROCORTISONE AND RU486 (MIFEPRISTONE) ON IODIDE UPTAKE IN PORCINE THYROID-CELLS IN PRIMARY CULTURE Reviewed

    Y TAKIYAMA, H TANAKA, Y TAKIYAMA, MAKINO, I

    ENDOCRINOLOGY   135 ( 5 )   1972 - 1979   1994.11

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  • In vitro monitoring activation by the ligands and specific DNA-binding of the glucocorticoid receptors. Reviewed

    Tanaka H., Fukawa E., Hirano H., Makino Y., Aoki A., Morikawa Y., Takiyama Y., Tani T., Makino I.

    Endocrinologica Japonica (Endocrine Journal)   39   477 - 483   1992

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    DOI: 10.1507/endocrj1954.39.477

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  • Methimazole regulation of thyroglobulin biosynthesis and gene transcription in rat FRTL-5 thyroid cells. Reviewed

    Isozaki O., Tsushima T., Emoto N., Saji M., Tsuchiya Y., Demura H., Sato Y., Shizume K., Kimura S., Kohn LD, Tsuchiya:Maiden name

    Endocrinology   128   3113 - 3121   1991

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  • Effect of lithium on deoxyribonucleic acid synthesis and iodide uptake in porcine thyroid cells in culture Reviewed

    Tsuchiya Y., Saji M., Isozaki O., Arai M., Tsushima T., Shizume K., Tsuchiya:Maiden name

    Endocrinology   126   460 - 465   1990

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    DOI: 10.1210/endo-126-1-460

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  • A 3, 3’, 5-triiodothyronine autoantibody (IgG, lambda) in a case of Hashimoto’s thyroiditis. Reviewed

    Muratsugu M., Tsuchiya Y., Makino M., suchiya:Maiden name

    Clin Chim Acta   178   171 - 180   1988

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  • The inhibitory effect of iodide on growth of rat thyroid (FRTL-5) cells. Reviewed

    Saji M., Isozaki O., Tsushima T., Arai M., Miyakawa M., Ohba Y., Tsuchiya Y., Sano T., Shizume K., Tsuchiya:Maiden Name

    Acta Endocrinologica(Copenh)   119   145 - 151   1988

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Books

  • 期待される新規糖尿病性腎症治療薬。糖尿病性腎症エキスパートブック: state of the art

    滝山 由美( Role: Sole author)

    南江堂  2016.3 

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  • 糖尿病腎症の成因・病態

    滝山 由美, 羽田 勝計( Role: Joint author)

    西村書店  2015.5 

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  • 期待されるチアゾリジン薬/チアゾリジンが期待される理由/腎保護作用

    滝山 由美, 羽田 勝計( Role: Joint author)

    有限会社フジメディカル出版  2013.5 

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  • ヴィジュアル 糖尿病臨床のすべて 「糖尿病予防と治療のエビデンス」 合併症の疫学 腎症の疫学

    滝山 由美, 羽田 勝計( Role: Joint author)

    中山書店  2012.5  ( ISBN:9784521733807

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  • Animal Models

    ( Role: Joint author)

    2010.8 

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MISC

  • 脂質異常症

    滝山由美

    暮らしと健康の月刊誌ケア   42 ( 3 )   38 - 44   2024.3

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  • 脂質異常症

    滝山 由美

    医療と介護ナビ   10 - 13   2023.12

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  • 最新の糖尿病診療と今後の展開 「ステロイド糖尿病」

    滝山 由美

    内科   129 ( 5 )   2022.5

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  • 糖尿病性腎臓病(DKD)の診断と最新治療について

    滝山 由美

    medicina   58 ( 10 )   1538 - 1541   2021.9

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  • がん 胎生期過栄養誘発NAFLD関連肝癌 HIF-1α/HORMAD1 pathwayの役割

    滝山 貴央, 石黒 美智代, 滝山 侑里, 佐々木 彩華, 別所 瞭一, 橘内 博哉, 竹田 安孝, 西川 祐司, 世良 俊博, 中村 匡徳, 堀家 慎一, 滝山 由美

    糖尿病合併症   35 ( Suppl.1 )   180 - 180   2021.9

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  • 胎生期過栄養によるNASH肝細胞癌発生機序の検討

    滝山 貴央, 宿田 夕季, 別所 瞭一, 橘内 博哉, 竹田 安孝, 坂上 英充, 世良 俊博, 中村 匡徳, 星野 真人, 上杉 健太朗, 堀家 慎一, 西川 祐司, 滝山 由美

    糖尿病   64 ( Suppl.1 )   P - 1   2021.5

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  • SPring-8の放射光を用いたマイクロCTによる腎臓の解析

    滝山由美, 世良俊博, 中村匡徳, 羽田勝計

    月刊 腎臓内科   13 ( 4 )   510 - 518   2021.2

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  • Maternal Overnutrition Causes DNA Alkylation in Fetal Liver, Suppresses FasL, and Upregulates HIF-1 Signaling Pathway in Neonatal Liver in Nonalcoholic Steatohepatitis (NASH)-Based Hepatocellular Carcinoma in Offspring

    Takao Takiyama, Ryoichi Bessho, Kazuki Sawamoto, Yumi Takiyama

    DIABETES   69   2020.6

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    DOI: 10.2337/db20-1845-P

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  • Two Sibling Cases of Mitochondrial Diabetes Mellitus Presented With Different Clinical Courses and Related Complications

    阿部智絵, 竹田安孝, 別所瞭一, 酒井健太郎, 中村知伸, 柳町剛司, 坂上英充, 藤田征弘, 安孫子亜津子, 滝山由美, 太田嗣人

    糖尿病(Web)   62 ( 3 )   2019

  • DPP-4とNeutral endopeptidase 24.11(NEP)がオキシントモジュリン(OXM)の生理活性に与える影響は異なる

    柳町剛司, 藤田征弘, 藤田征弘, 竹田安孝, 坂上英充, 別所瞭一, 滝山由美, 安孫子亜津子, 太田嗣人

    糖尿病(Web)   62 ( Suppl )   2019

  • 放射光imagingによる糖尿病糸球体構造評価

    滝山 由美

    DIABETES UPDATE   6 ( 3 )   52 - 53   2017.7

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  • SGLT2 Inhibitor Therapy Improves Blood Glucose but Does Not Prevent Albuminuria nor Glomerular Hypertrophy in Diabetic db/db Mice

    Yumi Takiyama, Toshihiro Sera, Masanori Nakamura, Tsuyoshi Yanagimachi, Ryoichi Bessho, Yukihiro Fujita, Masato Hoshino, Kentaro Uesugi, Yasuaki Saijo, Naoto Yagi, Masakazu Haneda

    DIABETES   66   A134 - A134   2017.6

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  • 糖尿病性腎症のサロゲートマーカーとは

    滝山 由美

    Current Therapy   35 ( 1 )   80   2017.1

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  • 外因性グルカゴンによる血糖値の上昇(ΔGlucose)の臨床的意義に関する検討

    竹田安孝, 藤田征弘, 佐藤茉欧, 高橋耕平, 酒井健太郎, 中村知伸, 阿部智絵, 柳町剛司, 辻賢, 坂上英充, 本庄潤, 安孫子亜津子, 滝山由美, 牧野雄一, 羽田勝計

    糖尿病(Web)   60 ( Suppl )   2017

  • Zinc; HIF-1 Mimetic in Human Renal Proximal Tubular Cells

    Ryoichi Bessho, Yumi Takiyama, Manami Maeda, Kuralay K. Atageldiyeva, Yukihiro Fujita, Masakazu Haneda

    DIABETES   65   A137 - A137   2016.6

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  • 糖尿病腎症の病因・病理・病態-糖尿病腎症の新展開-

    滝山由美, 羽田勝計

    日本臨床   74 ( 増刊号2 )   158 - 163   2016

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  • 糖尿病で膵short-form GIPの発現は増加し,持効型short-form GIP投与はlow-dose STZ誘発性糖尿病マウスの耐糖能異常を改善する

    柳町剛司, 藤田征弘, 竹田安孝, 本庄潤, ATAGELDIYEVA Kuralay, 滝山由美, 安孫子亜津子, 牧野雄一, 羽田勝計

    糖尿病(Web)   59 ( Suppl )   2016

  • 糖尿病腎症の診断と治療 Up To Date. SGLT2阻害薬への期待.

    滝山 由美

    月刊「糖尿病」   7 ( 12 )   69 - 78   2015.12

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  • Low carbohydrate diet and SGLT-2 inhibitors dissimilarly influenced on body weight and adiposity in normal mice

    K. K. Atageldiyeva, Y. Fujita, T. Yanagimachi, J. Honjo, A. Abiko, Y. Takiyama, Y. Makino, M. Haneda

    DIABETOLOGIA   58   S365 - S366   2015.9

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  • A New Player in Diabetic Nephropathy: Metallothionein 3 Is a Target for Hypoxia Inducible Factor-1

    Yumi Takiyama, Manami Maeda, Kuralay K. Atageldiyeva, Tsuyoshi Yanagimachi, Jun Honjo, Yukihiro Fujita, Atsuko Abiko, Masakazu Haneda

    DIABETES   64   A142 - A142   2015.6

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  • Can Skin AGEs Predict the Progression of Diabetic Nephropathy in Diabetic Patients?

    Atsuko Abiko, Tomonobu Nakamura, Kentaro Sakai, Yuki Nagashima, Ken Tsuji, Kanaki Ishizeki, Yukihiro Fujita, Yumi Takiyama, Masakazu Haneda

    DIABETES   64   A150 - A151   2015.6

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  • 糖尿病腎症の病因・病理・病態―糖尿病腎症の新展開―. 新時代の臨床糖尿病学(下)-より良い血糖管理をめざしてー.

    滝山 由美, 羽田 勝計

    日本臨床   463 - 470   2015.5

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  • Zinc exerts anti-fibrotic action by inhibiting TGF-beta1-induced type I collagen and fibronectin in human renal proximal tubular cells

    Y. Takiyama, M. Maeda, K. K. Atageldiyeva, T. Yanagimachi, J. Honjo, Y. Fujita, Y. Makino, M. Haneda

    DIABETOLOGIA   57   S480 - S480   2014.9

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  • The long-acting analogue of short-form GIP does not induce obesity in normal mice but ameliorates chronic hyperglycaemia in low-dose streptozotocin-induced diabetic mice

    Y. Fujita, T. Yanagimachi, K. K. Atageldieyeva, J. Honjo, Y. Takiyama, A. Abiko, Y. Makino, M. Haneda

    DIABETOLOGIA   57   S223 - S223   2014.9

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  • SGLT2 Inhibitor Luseogliflozin (TS-071) Protects from Diabetic Nephropathy in an Animal Model of Type 2 Diabetes

    Yumi Takiyama, Ryoichi Bessho, Manami Maeda, Kuralay K. Atageldiyeva, Tsuyoshi Yanagimachi, Jun Honjo, Yukihiro Fujita, Yuichi Makino, Masakazu Haneda

    DIABETES   63   A136 - A136   2014.6

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  • 糖尿病性腎症の成因

    羽田 勝計

    月刊 糖尿病   6 ( 2 )   14 - 23   2014.2

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  • Luseogliflozin (TS-071), a novel SGLT2 inhibitor, protects against diabetic nephropathy in diabetic db/db mice

    Y. Takiyama, K. Agatsuma, M. Yasuda-Kobayashi, J. Honjo, Y. Fujita, T. Yanagimachi, H. Kitsunai, Y. Makino, M. Haneda

    DIABETOLOGIA   56   S66 - S66   2013.9

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  • Usefulness of Estimated GFR by Cystatin C from the Survey of the Relationship between Dipstick Proteinuria and Urine Albumin-Creatinine Ratios in Type 2 Diabetic Patients

    Atsuko Abiko, Kentaro Sakai, Yoshinari Arai, Yuki Nagashima, Ken Tsuji, Hidemitsu Sakagami, Kanaki Ishizeki, Yukihiro Fujita, Yumi Takiyama, Masakazu Haneda

    DIABETES   62   A609 - A609   2013.7

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  • TGF-Beta1 Inhibits Sodium Glucose Cotransporter 2 (SGLT2) Expression in Human Renal Proximal Cells Reviewed

    Kumiko Agatsuma, Yumi Takiyama, Jun Honjo, Yukihiro Fujita, Tsuyoshi Yanagimachi, Hiroya Kitsunai, Hidemitsu Sakagami, Yuichi Makino, Masakazu Haneda

    DIABETES   62   A135 - A135   2013.6

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  • HIF-1 alpha as a Novel Molecular Target in Anticancer Effects of Metformin

    Yumi Takiyama, Jun Honjo, Yukihiro Fujita, Tsuyoshi Yanagimachi, Hiroya Kitsunai, Hidemitsu Sakagami, Yuichi Makino, Masakazu Haneda

    DIABETES   61 ( supple. )   A235 - A236   2012.6

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  • Early DPP-4 inhibition suppresses the progression of diabetes in low-dose STZ mice via alleviation of beta cell death and alpha cell proliferation

    Y. Takeda, Y. Fujita, J. Honjo, T. Yanagimachi, H. Kitsunai, Y. Takiyama, Y. Makino, A. Abiko, M. Haneda

    DIABETOLOGIA   54   S214 - S214   2011.9

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  • 糖尿病性腎症の病態

    滝山 由美, 羽田 勝計

    血圧   18 ( 2 )   124 - 128   2011.2

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  • Renal Tubulointerstitial Fibrosis in Type 2 Diabetic Rats Is Prevented by Metformin: A Possible Role of HIF-1 alpha Expression and Oxygen Metabolism

    Yumi Takiyama, Jun Watanabe, Tatsuo Harumi, Yukihiro Fujita, Jun Honjyo, Norihiko Shimizu, Yuichi Makino, Yasutaka Takeda, Masakazu Haneda

    DIABETES   59   A249 - A249   2010.6

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  • Early DPP-4 Inhibition Suppresses the Progression of Diabetes in Low-Dose STZ Mice

    Yasutaka Takeda, Yukihiro Fujita, Jun Honjo, Yumi Takiyama, Yuichi Makino, Atsuko Abiko, Masakazu Haneda

    DIABETES   59   A435 - A436   2010.6

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  • Metformin inhibits HIF-1alpha expression in human anaplastic thyroid cancer cells by suppressing mitochondrial respiration

    Yumi Takiyama, Yukihiro Fujita, Masakazu Haneda

    ENDOCRINE JOURNAL   57   S468 - S468   2010.3

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  • Pathogenesis of diabetic nephropathy: Role of hypoxia-inducible factor-1a(HIF-1 alpha)

    Masakazu Haneda, Yuichi Makino, Yumi Takiyama

    ENDOCRINE JOURNAL   57   S219 - S219   2010.3

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  • Insulin-Like Growth Factor Binding Protein-Related Protein 1 (IG-FBP-rP1) as a Possible Biomarker of Proximal Tubule Injury in Type-2 Diabetic Patients with Proteinuria

    Jun Watanabe, Yumi Takiyama, Jun Honjo, Hidemitu Sakagami, Yuichi Makino, Yasutaka Takeda, Yukihiro Fujita, Masatoshi Tateno, Masakazu Haneda

    DIABETES   58   A216 - A216   2009.6

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  • 糖尿病性腎症の医療経済は?糖尿病性腎症にはどれぐらい医療費がかかりますか

    滝山 由美, 羽田 勝計

    肥満と糖尿病   8   682 - 683   2009.4

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  • TGF-beta 1 upregulates insulin-like growth factor binding protein (IGFBP)7 expression in human renal proximal tubular epithelial cell (HRPTEC)

    J. Watanabe, Y. Takiyama, I. Honjyo, T. Isoe, H. Sakagami, Y. Makino, Y. Fujita, M. Haneda

    DIABETOLOGIA   51   S480 - S480   2008.9

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  • Metformin inhibits the expressions of HIF-1 alpha and PAI-1 through the inhibition of mitochondria I respiratory chain complex I in human renal proximal tubular epithelial cells (HRPTECs) in culture

    Yumi Takiyama, Jun Watanabe, Jun Honjyo, Tsubasa Isoe, Hidemitsu Sakagami, Masahiro Fujita, Yuichi Makino, Masakazu Haneda

    DIABETES   57   A215 - A215   2008.6

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  • High glucose activates the hypoxia-inducible factors (HIFs)-mediated signal transduction in human glomerular mesangial

    Tsubasa Isoe, Yuichi Makino, Hidemitsu Sakagami, Jun Honi, Kensaku Okamoto, Yumi Takiyama, Yukihiro Fujita, Atsuko Abiko, Hiroshi Itoh, Masa-Kazu Haneda

    DIABETES   57   A212 - A212   2008.6

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  • Renoprotective effects of metformin

    Yumi Takiyama, Jun Honjyo, Yuichi Makino, Tsubasa Isoe, Masakazu Haneda

    DIABETES   56   A603 - A604   2007.6

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  • The Renometabolic Syndrome-糖尿病性腎症進展予防に対する治療戦略標的としてのInterleukin-18(IL-18)-

    滝山 由美, 本庄 潤, 立野 正敏, 羽田 勝計

    Therapeutic Research   28   1497 - 1500   2007.4

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  • Interleukin-18 (IL-18) expression is up-regulated in renal tubular cells in type 2 diabetic subjects with nephropathy

    Yumi Takiyama, Kazunari Miyauchi, Jun Honjyo, Seir Uebori, Tsubasa Isoe, Atsuko Abiko, Hiroshi Ito, Masatoshi Tateno, Masakazu Haneda

    DIABETES   55   A184 - A184   2006.6

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  • High glucose increases the expression of neurokinin1 receptors in cultured neonatal rat spinal neurons

    Kanaki Ishizeki, Atsuko Abiko, Yumi Takiyama, Hiroshi Ito, Tetsuya Moriai, Masakazu Haneda

    DIABETES   55   A510 - A510   2006.6

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  • 自己免疫性甲状腺疾患と甲状腺癌におけるIL-18の発現

    滝山 由美, 三代川 斎之, 徳差 良彦, 伊藤 公一, 加藤 志津夫, 木村 昭治, 佐藤 啓介, 立野 正敏

    ホルモンと臨床   51   111 - 117   2003

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  • The structural requirement of DAP12/CD158 KAR association

    S Kimura, N Aoki, Y Takiyama, Y Atsuta, A Abe, K Oikawa, M Katagiri

    FASEB JOURNAL   14 ( 6 )   A1018 - A1018   2000.4

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  • The important role of DAP12 signal on mouse myeloid defferentiation

    N Aoki, S Kimura, Y Takiyama, Y Atsuta, A Abe, S Chiba, K Sato, M Katagiri

    FASEB JOURNAL   14 ( 6 )   A1233 - A1233   2000.4

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Presentations

  • 糖尿病腎症におけるMetallothionein 3の役割

    滝山 侑里, 滝山 由美, 南部 孝, 丸山 二美可, 佐藤 翼, 宿田 夕季, 滝山 貴央, 栗垣 彩華, 橘内 博哉, 野本 博司

    第38日本糖尿病・肥満動物学会年次学術集会  2025.3 

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    Event date: 2025.3

    Presentation type:Oral presentation (general)  

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  • 胎生期発生脂肪肝炎/肝癌モデルマウスにおけるSGLT2阻害薬の治療効果:低酸素応答とmetabolic rewiringの是正

    滝山 貴央, 南部 孝, 丸山 二美可, 佐藤 翼, 滝山 侑里, 宿田 夕季, 橘内 博哉, 滝山 由美, 野本 博司

    第38日本糖尿病・肥満動物学会年次学術集会  2025.3 

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    Event date: 2025.3

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  • 妊娠糖尿病におけるSmall for Gestational Age児出生関連母体因子の検討

    宿田夕季, 平間凛, 滝山侑里, 佐々木大河, 滝山貴央, 土井田貴美子, 栗垣彩華, 橘内博哉, 滝山由美

    第67回日本糖尿病学会年次学術集会  2024.5 

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    Event date: 2024.5

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  • 糖尿病腎症におけるMetallothionein3/Klotho/FGFRs Pathway

    滝山侑里, 平間 凛, 佐々木 大河, 宿田 夕季, 滝山 貴央, 土井田 貴美子, 栗垣 彩華, 橘内 博哉, 滝山 由美

    第67回日本糖尿病学会年次学術集会  2024.5 

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  • 選択的静脈サンプリングにより局在診断に至った無症候性原発性副甲状腺機能亢進症の一例

    南部 孝, 橘内 博哉, 平間 凜, 滝山 侑里, 佐々木 大河, 宿田 夕季, 滝山 貴央, 栗垣 彩華, 滝山 由美

    第300回 日本内科学会北海道地方会 

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    Event date: 2024.2

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  • 難治性吃逆を契機に診断されたACTH分泌不全症の一例

    早川 弘恵, 平間 凛, 山縣 二美可, 滝山 侑里, 佐々木 大河, 土井田 貴美子, 滝山 貴央, 橘内 博哉, 滝山 由美

    第33回 臨床内分泌代謝Update 

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    Event date: 2023.11

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  • 2型糖尿病の経過中に抗GAD抗体が陽転化した多腺性自己免疫症候群3型の一例

    佐々木 大河, 早川 弘恵, 平間 凛, 山縣 二美可, 滝山 侑里, 滝山 貴央, 橘内 博哉, 滝山 由美

    第57回 日本糖尿病学会北海道地方会 

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    Event date: 2023.10

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  • 長期間の低血糖症状から耐糖能異常の診断に至った一例

    平間 凜, 早川 弘恵, 山縣 二美可, 佐々木 大河, 滝山 侑里, 滝山 貴央, 橘内 博哉, 滝山 由美

    第57回 日本糖尿病学会北海道地方会 

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    Event date: 2023.10

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  • 低LDL-C血症を契機に診断し得た視床下部性副腎皮質機能低下症の一症例

    山縣 二美可, 早川 弘恵, 平間 凛, 佐々木 大河, 滝山 侑里, 滝山 貴央, 橘内 博哉, 滝山 由美

    第23回 日本内分泌学会北海道支部学術集会 

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    Event date: 2023.10

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  • 近位尿細管細胞特異的ヒトMetallothionein 3トランスジェニックマウスにおける脂肪毒性腎病変

    滝山 侑里, 早川 弘恵, 平間 凛, 山縣 二美可, 佐々木 大河, 土井田 貴美子, 滝山 貴央, 栗垣 彩華, 橘内 博哉, 滝山 由美

    第38回 日本糖尿病合併症学会 

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    Event date: 2023.10

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  • Fetal Renal Hypoxia Response To Maternal Overnutrition International conference

    Takao Takiyama, Yuri Takiyama, Ryoichi Bessho, Taiga Sasaki, Hiroki Yamagata, Hiroya Kitsunai, Yumi Takiyama

    American Diabetes Association 83rd Scietific Sessions 

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    Event date: 2023.6

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  • Renal Proximal Tubular Metallothionein 3 Contributes To Diabetic Kidney Lesion International conference

    Yuri Takiyama, Takao Takiyama, Ryoichi Bessho, Hiroya Kitsunai, Yumi Takiyama

    American Diabetes Association 83rd Scientific Sessions 

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    Event date: 2023.6

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  • 新たな糖尿病腎症画像診断法としてのMRI拡散強調画像 法の可能性

    橘内 博哉, 滝山 由美, 中川 直樹, 沖崎 貴琢, 羽田 勝計

    第66回日本糖尿病学会年次学術集会 

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    Event date: 2023.5

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  • Linagliptin attenuates albuminuria in streptozotocin-induced diabetic nephropathy independent of Nrf2 signaling

    Suratsawadee Promsuwan, Kazuki Sawamoto, Ryoichi Bessho, Yuri Takiyama, Takao Takiyama, Hiroya Kitsunai, Yumi Takiyama

    第66回日本糖尿病学会年次学術集会 

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    Event date: 2023.5

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  • Nrf2欠損マウスにおけるglucoraphaninの腎保護効果

    別所瞭一, 滝山侑里, Suratsawadee Promsuwan, 滝山貴央, 澤本一樹, 橘内博哉, 竹田安孝, 滝山由美

    第33回日本糖尿病性腎症研究会 

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    Event date: 2022.12

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  • グルコラファニンによる肥満・脂肪肝に対する治療効果

    Promsuwan Suratsawadee, 澤本 一樹, 長田 直人, Xu Liang, 滝山 由美

    第37回日本糖尿病合併症学会 

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    Event date: 2022.10

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  • MRI 拡散強調画像法を用いた新規糖尿病腎症診断法

    橘内博哉, 滝山由美, 中川直樹, 沖崎貴琢, 羽田勝計

    第37回日本糖尿病合併症学会 

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    Event date: 2022.10

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  • 抗PD-L1抗体により複数の免疫関連有害事象発症後1型糖尿病が続発した一例

    滝山 侑里, 橘内 博哉, 佐々木 大河, 栗垣 彩華, 別所 瞭一, 竹田 安孝, 滝山 由美

    第56回日本糖尿病学会北海道地方会 

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    Event date: 2022.10

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  • チアマゾール治療抵抗性バセドウ病の一例

    橘内 博哉, 滝山 侑里, 佐々木 大河, 栗垣 彩華, 別所 瞭一, 竹田 安孝, 沖崎 貴琢, 滝山 由美

    第22回日本内分泌学会北海道支部学術集会 

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    Event date: 2022.10

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  • 2型糖尿病の病型を呈したミトコンドリア糖尿病合併心筋症の一例

    佐々木 彩華, 別所 暸一, 滝山 侑里, 竹田 安孝, 橘内 博哉, 佐々木 大河, 滝山 由美

    第56回日本糖尿病学会北海道地方会 

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    Event date: 2022.10

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  • 下垂体腺腫を疑われたIgG4関連下垂体炎の一例

    佐々木 大河, 滝山 侑里, 佐々木 彩華, 別所 瞭一, 橘内 博哉, 竹田 安孝, 滝山 由美

    第22回日本内分泌学会北海道支部学術集会 

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    Event date: 2022.10

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  • 胎生期過栄養による 腎低酸素応答について

    滝山貴央, 世良俊博, 星野真人, 上杉健太朗, 中村匡徳, 滝山侑里, 別所瞭一, Suratsawadee Promsuwan, 佐々木彩華, 佐藤茉欧, 澤本一樹, 橘内博哉, 竹田安孝, 滝山由美

    第65回日本糖尿病学会年次学術集会 

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    Event date: 2022.5

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  • グルコラファニンは糖尿病腎組織においてSGLT2発現を減少させる

    別所 瞭一, 滝山 侑里, 滝山 貴央, Promsuwan Suratsawadee, 佐藤 茉欧, 澤本 一樹, 橘内 博哉, 竹田 安孝, 滝山 由美

    第65回日本糖尿病学会年次学術集会 

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    Event date: 2022.5

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  • 2型糖尿病モデルdb/dbマウスに対するGlucoraphaninの腎作用

    滝山 由美, 別所 暸一, 滝山 侑里, 滝山 貴央, 佐々木 彩華, 佐藤 茉央, 橘内 博哉, 竹田安孝

    第65回日本糖尿病学会年次学術集会 

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    Event date: 2022.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸  

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  • 2型糖尿病合併非アルコール性脂肪肝疾患に対するトホグリフロジンの有用性の検討

    滝山 侑里, 滝山 貴央, 佐々木 彩華, 別所 瞭一, 佐藤 茉央, 橘内 博哉, 竹田安孝, 坂上 英充, 滝山 由美

    第65回日本糖尿病学会年次学術集会 

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    Event date: 2022.5

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  • Glucoraphanin has the therapeutic potential of resolving hepatic steatosis in a murine model of diet-induced obesity. poster presentation. International conference

    uratsawadee Promsuwan, Kazuki Sawamoto, Naoto Nagata, Liang Xu, Yumi Takiyama

    International Diabetes Federation Congress 2021 

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    Event date: 2021.12

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  • 胎生期過栄養誘発NAFLD関連肝癌発症:HIF-1α/HORMAD1 pathway の役割

    滝山貴央, 石黒美智代, 滝山侑里, 佐々木彩華, 別所瞭一, 橘内博哉, 竹田安孝, 西川祐司, 世良俊博, 中村匡徳, 堀家眞一, 滝山由美

    第36回日本糖尿病合併症学会総会 

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    Event date: 2021.10

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  • Nrf2活性化剤スルフォラファンは近位尿細管細胞のTFAMを活性化しSTINGを抑制する

    別所 瞭一, 滝山 貴央, Suratsawadee Promsuwan, 滝山 侑里, 澤本 一樹, 橘内 博哉, 竹田 安孝, 滝山 由美

    第36回日本糖尿病合併症学会 

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    Event date: 2021.10

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  • Apparent diffusion coefficient on diffusion-weighted magnetic resonance imaging predicts the progression of renal damage in diabetic nephropathy. International conference

    Hiroya Kitsunai, Yumi Takiyama, Naoki Nakagawa, Naoyuki Hasebe, Atsutaka Okizaki, Masakazu Haneda

    American Diabetes Association 81st Scietific Sessions 

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    Event date: 2021.6

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  • The Nrf2 Activator Increases TFAM and Suppresses STING in Human Renal Proximal Tubular Cells International conference

    RYOICHI BESSHO, TAKAO TAKIYAMA, SURATSAWADEE PROMSUWAN, HIROYA KITSUNAI, KAZUKI SAWAMOTO, YASUTAKA TAKEDA, YUMI TAKIYAMA

    米国糖尿病学会学術集会 

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    Event date: 2021.6

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  • HORMAD1, A Novel Hypoxia-Inducible Factor-1 Target, Is Upregulated in Maternal Overnutrition-induced Non-Alcoholic Steatohepatitis (NASH)/ Hepatocellular Carcinoma International conference

    Takao Takiyama, Toshihiro Sera, Masanori Nakamura, Shin-ichi Horike, Yuji Nishikawa, Yumi Takiyama

    第81回米国糖尿病学会学術集会 

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    Event date: 2021.6

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  • Nrf2活性化剤によるTFAM活性化とSTING抑制作用

    別所 瞭一, 滝山 貴央, Suratsawadee Promsuwan, 宿田 夕季, 橘内 博哉, 澤本 一樹, 竹田 安孝, 坂上 英充, 滝山 由美

    第64回日本糖尿病学会年次学術集会 

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    Event date: 2021.6

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • 胎生期過栄養によるNASH肝癌発生機序の検討

    滝山 貴央, 宿田 夕季, 別所 瞭一, 橘内 博哉, 竹田 安孝, 坂上 英充, 西川 祐司, 世良 俊博, 中村 匡徳, 滝山由美

    第64回日本糖尿病学会年次学術集会. 

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    Event date: 2021.6

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  • 糖尿病腎症特異的診断法としてのMRI糖尿病腎症特異的診断法としてのMRI拡散強調画像法の可能性拡散強調画像法の可能性

    橘内 博哉, 滝山 由美, 中川 直樹, 長谷部 直幸, 沖崎 貴琢, 羽田 勝計

    第35回日本糖尿病合併症学会総会 

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    Event date: 2020.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

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  • 胎生期過栄養誘発脂肪肝炎/肝癌:HIF-1シグナル系の役割

    滝山貴央, 世良俊博, 中村匡徳, 堀家慎一, 西川祐司, 滝山由美

    第35回日本糖尿病合併症学会総会 

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    Event date: 2020.12

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  • 放射光CTイメージングによる1型糖尿病モデルマウス糸球体評価

    滝山由美, 世良俊博, 中村匡徳, 上杉健太朗, 星野正人, 滝山貴央, 別所瞭一, 橘内博哉, 竹田安孝, 八木直人, 羽田勝計

    第35回日本糖尿病合併症学会総会. 

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    Event date: 2020.12

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  • 糖尿病腎症 Up-to-Date

    滝山由美

    第54回日本糖尿病学会北海道地方会. 

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    Event date: 2020.11

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

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  • 糸球体可視化によるSGLT2阻害薬の効果

    滝山 由美

    第50回日本腎臓学会西部学術大会 

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    Event date: 2020.10

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

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  • 胎生期高脂肪食誘発脂肪肝炎-肝癌モテルマウスの確立

    滝山貴央, 滝山由美, 別所瞭一, 橘内博哉, 竹田安孝, 坂上英充, 西川祐司, 竹内文也, 世良俊博, 中村匡徳

    第63回日本糖尿病学会年次学術集会. 

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    Event date: 2020.10

    Language:Japanese   Presentation type:Poster presentation  

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  • 糖尿病腎症特異的診断法 ~MRI拡散強調画像法ADC0-700値は糖尿病腎症診断指標となる~

    橘内 博哉, 滝山 由美, 中川 直樹, 長谷部 直幸, 沖崎 貴琢, 竹内 文也, 羽田 勝計

    第63回日本糖尿病学会年次学術集会 

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    Event date: 2020.10

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • Maternal Overnutrition Causes DNA Alkylation in Fetal Liver, Suppresses FasL and Upregulates HIF-1 Signaling Pathway in Neonatal Liver in Non-Alcoholic Steatohepatitis (NASH)/Hepatocellular Carcinoma in Offspring. International conference

    Takao Takiyama, Ryoichi Bessho, Kazuki Sawamoto, Yumi Takiyama

    米国糖尿病学会学術集会 

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    Event date: 2020.6

    Language:English   Presentation type:Poster presentation  

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  • 放射光イメージングによる糸球体可視化

    滝山 由美

    第31回日本糖尿病性腎症研究会  日本糖尿病性腎症研究会

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    Event date: 2019.11 - 2019.12

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Venue:岡山市  

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  • 放射光糸球多イメージング法:SGLT2阻害薬による腎糸球体への効果

    滝山 由美

    第95回臨床内分泌代謝Update  日本内分泌学会

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    Event date: 2019.11

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:高知市  

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  • 放射光を用いた腎糸球体可視化法の開発

    滝山 由美, 世良 俊博, 中村 匡徳

    第19回日本NO学会学術集会 

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    Event date: 2019.6

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

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  • Synchrotron Radiation Micro-CT Reveals Glomerular Loss without Glomerular or Renal Hypertrophy in Streptozotocin-induced Type 1 Diabetic Mice International conference

    Yumi Takiyama, Toshihiro Sera, Masanori Nakmaura, Ryoichi Bessho, Takao Takiyama, Tsuguhito Ota, Masakazu Haneda

    American Diabetes Association 79th Scientific Sessions 

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    Event date: 2019.6

    Language:English   Presentation type:Poster presentation  

    Venue:SAN FRANCISCO  

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  • A Novel Renoprotective Target of SGLT2 Inhibitor: HIF-1α Inhibition and AMPK Activation in Renal Proximal Tubular Epithelial Cells International conference

    Ryoichi Bessho, Yumi Takiyama, Takao Takiyama, Tsuguhito Ota

    第70回アメリカ糖尿病学会学術集会 

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    Event date: 2019.6

    Language:English   Presentation type:Poster presentation  

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  • Metformin: multi-target drug in type 2 diabetes

    Yumi Takiyama

    第62回日本糖尿病学会年次学術集会 

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    Event date: 2019.5

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

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  • SGLT2 阻害薬の新規腎保護作用機構: ミトコンドリア酸素消費抑制を介したHIF-1α蛋白発現抑制とAMPK活性化

    別所瞭一, 滝山由美, 太田嗣人

    第62回日本糖尿病学会年次学術集会 

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    Event date: 2019.5

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • MRI拡散強調画像解析を用いた糖尿病腎症診断法の開発

    橘内博哉, 滝山 由美, 中川 直樹, 長谷部 直幸, 佐々木 智章, 沖崎 貴琢, 竹内 文也, 羽田 勝計, 太田 嗣人

    第62回日本糖尿病学会年次学術集会 

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    Event date: 2019.5

    Language:Japanese   Presentation type:Poster presentation  

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  • SGLT2阻害薬による近位尿細管細胞低酸素誘導転写因子HIF-1発現抑制作用

    SGLT, 阻害薬による近位尿細管細胞低酸素誘導転写因子HIF, 発現抑制作用

    第30回日本糖尿病性腎症研究会  日本糖尿病性腎症研究会

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    Event date: 2018.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京  

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  • Luseogliflozin Inhibits HIF-1a Expression in Renal Proximal Tubular Epithelial Cells International conference

    Yumi Takiyama, Ryoichi Bessho, Tsuguhito Ota

    54th Annual Meeting of the European Association for the Study of Diabetes  European Association for the Study of Diabetes

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    Event date: 2018.10

    Language:English   Presentation type:Poster presentation  

    Venue:Berlin, Germany  

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  • Luseogliflozin Inhibits HIF-1α Expression in Renal Proximal Tubular Epithelial Cells International conference

    Ryoichi Bessho, Yumi Takiyama, Tsuguhito Ota

    American Diabetes Association. 78th Scientific Sessions  American Diabetes Association

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    Event date: 2018.6

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Orlando, FL, USA  

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  • MRI拡散強調画像解析による糖尿病性腎症診断法開発の検討

    滝山 由美, 中川 直樹, 長谷部直幸, 沖崎 貴琢, 高橋 康二, 羽田 勝計, 太田嗣人

    第29回日本糖尿病性腎症研究会 

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    Event date: 2017.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京  

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  • 直接作用型抗ウイルス薬(direct acting antivirals; DAAs) 治療後、血糖改善を呈した2型糖尿病の一症例

    滝山 由美, 別所 瞭一, 酒井 健太郎, 阿部 智恵, 中村 知伸, 竹田 安孝, 坂上 英充, 藤田 征弘, 安孫子 亜津子

    第51回日本糖尿病学会北海道地方会 

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    Event date: 2017.11

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • A Novel Mouse Model of Maternal Overnutrition-induced Non-Alcoholic Steatohepatitis (NASH)/ Hepatocellular Carcinoma International conference

    Y. Takiyama, M. Nakamura, T. Sera, K. Uesugi, M. Hoshino, N. Yagi, M. Haneda

    53rd Annual Meeting of the European Association for the Study of Diabetes 

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    Event date: 2017.9

    Language:English   Presentation type:Poster presentation  

    Venue:Lisbon, Portugal  

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  • SGLT2 Inhibitor Therapy Improves Blood Glucose But Does Not Prevent Albuminuria Nor Glomerular Hypertrophy in Diabetic Db/db Mice International conference

    Yumi Takiyama, Toshihiro Sera, Masanori Nakmaura, Tsuyoshi Yanagimachi, Ryoichi Bessho, Yukihiro Fujita, Masato Hoshino, Kentaro Uesugi, Yasuaki Saijo, Naoto Yagi, Masakazu Haneda

    American Diabetes Association. 77th Scientific Sessions 

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    Event date: 2017.6

    Language:English   Presentation type:Poster presentation  

    Venue:San Diego, CA, USA  

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  • Glomerular Number and Volume in Diabetic Kidney Estimated by Synchrotron Radiation Micro-Computed Tomography at SPring-8. 放射光imaging糖尿病による腎糸球体構造評価

    滝山 由美, 世良 俊博, 中村 匡徳, 上杉 健太朗, 星野 正人, 八木 直人, 西條 泰明, 羽田 勝計

    第60回日本糖尿病学会学術集会 

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    Event date: 2017.5

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

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  • 新規腎糸球体イメージング法の検討:腎糸球体に及ぼす糖尿病の影響

    滝山 由美, 世良 俊博, 中村 匡徳, 上杉 健太朗, 星野 正人, 八木 直人, 西條 泰明, 羽田 勝計

    第 28回日本糖尿病性腎症研究会 

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    Event date: 2016.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京  

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  • A New Model for Diabetic Nephropathy: A Hypoxia-Induced Antioxidant Metallothionein-3 BACTG mice. International conference

    Yumi Takiyama, Ryoichi Bessho, Takahiko Nakagawa, Masakazu Haneda

    アメリカ腎臓学会 

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    Event date: 2016.11

    Language:English   Presentation type:Poster presentation  

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  • 中枢性甲状腺機能低下症に対するT3,T4併用療法の一例

    滝山 由美, 滝山 義之, 江口 耕平, 牧野 雄一

    日本内分泌学会 第16回 北海道支部学術集会 

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    Event date: 2016.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:札幌  

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  • SGLT2阻害剤治療1年後造血亢進を呈した一症例

    滝山 由美, 酒井 健太郎, 阿部 智恵, 中村 知伸, 竹田 安孝, 辻 賢, 坂上 英充, 本庄 潤, 藤田 征弘, 安孫子 亜津子, 羽田 勝計

    第50回日本糖尿病学会北海道地方会 

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    Event date: 2016.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:札幌  

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  • A novel approach for estimating glomerular number and volume using synchrotron radiation micro-CT in SPring-8: The impacts of Diabetes on glomeruli. International conference

    Yumi Takiyama

    第15回日韓腎症セミナー 

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    Event date: 2016.10

    Language:English   Presentation type:Oral presentation (invited, special)  

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  • 新規糖尿病腎症モデル:低酸素誘導抗酸化物質Metallothionein3トランスジェニックマウス

    滝山 由美, 別所 瞭一, 藤田 征弘, 安孫子 亜津子, 立野 正敏, 仲川 孝彦, 羽田 勝計

    第31回日本糖尿病合併症学会。 

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    Event date: 2016.10

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:仙台  

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  • Zinc; HIF-1 mimetic in Human Renal Proximal Tubular Cells. International conference

    Ryoichi Bessho, Yumi Takiyama, Manami Maeda, Kuralay K. Atageldiyeva, Yukihiro Fujita, Atsuko Abiko, Masakazu Haneda

    第76回アメリカ糖尿病学会 

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    Event date: 2016.6

    Language:English   Presentation type:Poster presentation  

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  • ヒト近位尿細管細胞において、亜鉛はTGF-β1誘導線維化を抑制しHIF-1 target遺伝子発現を増強する

    別所 瞭一, 前田 愛実, 滝山 由美, Kuralay. K. Atageldiyeva, 柳町 剛司, 長南 茉欧, 高橋 耕平, 酒井 健太郎, 中村 知伸, 永島 優樹, 竹田 安孝, 辻 賢, 本庄 潤, 藤田 征弘, 安孫子 亜津子, 羽田 勝計

    第 59 回日本糖尿病学会年次学術集会 

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    Event date: 2016.5

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • Metallothionein3 トランスジェニックマウスは、高血糖無しに糖尿病性腎症類似病変を呈する

    滝山 由美, 別所 瞭一, 柳町 剛司, 藤田 征弘, 立野 正敏, 仲川 孝彦, 羽田 勝計

    第 27 回日本糖尿病性腎症研究会. 

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    Event date: 2015.12

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • ヒト糖尿病性腎症近位尿細管における抗酸化物質Metallothionein3の発現制御機構の検討.

    滝山 由美, 別所 瞭一, 柳町 剛司, 本庄 潤, 藤田 征弘, 羽田 勝計

    第30回日本糖尿病合併症学会 

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    Event date: 2015.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

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  • The impact of Diabetes on Total Glomerular Numbers and Size in Kidney Estimated by Synchrotron Radiation Micro-CT in SPring-8. International conference

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    Event date: 2015.11

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  • Upregulated Metallothionein (MT) 3 Expression in Human Diabetic Kidney: Hypoxia Induced MT3 Expression via HIF-1a In Human Renal Proximal Tubular Epithelial Cells. International conference

    Yumi Takiyama, Masakazu Haneda

    The 14th Japan-Korea Diabetic Nephropathy Seminar. 

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    Event date: 2015.10 - 2015.11

    Language:English   Presentation type:Oral presentation (invited, special)  

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  • A New Player in Diabetic Nephropathy: Metallothionein 3 Is A Target For Hypoxia Inducible Factor-1 International conference

    Yumi Takiyama, Manami Kobayashi, Kuralay Atageldiyeva, Tsuyoshi Yanagimachi, Jun Honjo, Yukihiro Fujita, Masakazu Haneda

    American Diabetes Association, 75th Scientific Sessions. 

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    Event date: 2015.6

    Language:English   Presentation type:Poster presentation  

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  • 新規HIF-1標的遺伝子Metallothionein-3の 糖尿病性腎症病態関与についての検討

    滝山 由美, 前田 愛実, Kuralay K. Atageldiyeva, 柳町 剛司, 本庄 潤, 藤田 征弘, 羽田 勝計

    第58回日本糖尿病学会年次学術集会. 

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    Event date: 2015.5

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • Metallothionein-3は、新規HIF-1標的遺伝子であり、糖尿病性腎症病態に関与する.

    滝山 由美, 前田 愛実, Kuralay K. Atageldiyeva, 柳町 剛司, 本庄 潤, 藤田 征弘, 羽田 勝計

    第 26 回日本糖尿病性腎症研究会. 

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    Event date: 2014.12

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • SGLT2阻害薬の腎保護効果についての検討.

    滝山 由美, 前田 愛実, Kuralay, K. Atageldiyeva, 柳町 剛司, 本庄 潤, 藤田 征弘, 牧野 雄一, 羽田 勝計

    第29回日本糖尿病合併症学会. 

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    Event date: 2014.11

    Language:English   Presentation type:Symposium, workshop panel (public)  

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  • Metallothionein (MT)-3 is a Novel Direct Target of Hypoxia Inducible Factor-1 alpha (HIF-1a). International conference

    Yumi Takiyama, Manami Maeda, Kuralay K. Atageldiyeva, Tsuyoshi Yanagimachi, Jun Honjo, Yukihiro Fujita, Masakazu Haneda

    The American Society of Nephrology Annual Meeting & Scientific Exposition. 

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    Event date: 2014.11

    Language:English   Presentation type:Poster presentation  

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  • The SGLT2 inhibitor Luseogliflozin Protects Against Diabetic Nephropathy in Diabetic db/db Mice. International conference

    Yumi Takiyama

    The 13th Japan-Korea Diabetic Nephropathy Seminar. 

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    Event date: 2014.9

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

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  • Zinc Exerts Anti-Fibrotic Action by Inhibiting TGF-β1-induced Type I Collagen and Fibronecin in Human Renal Proximal Tubular Cells. International conference

    Yumi Takiyama, Manami Maeda, Kuralay K. Atageldiyeva, Tsuyoshi Yanagimachi, Jun Honjo, Yukihiro Fujita, Yuichi Makino, Masakazu Haneda

    The European Association for the Study of Diabetes, 50th Annual Meeting. 

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    Event date: 2014.9

    Language:English   Presentation type:Poster presentation  

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  • SGLT2阻害薬の腎保護効果.

    滝山 由美, 羽田 勝計

    第18回日本適応医学会学術集会. 

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    Event date: 2014.6

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

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  • SGLT2 inhibitor Luseogliflozin (TS-071) Protects from Diabetic Nephropathy in an Animal Model of Type 2 Diabetes. International conference

    Yumi Takiyama, Ryoichi Bessho, Manami Maeda, Kuralay K. Atageldiyeva, Tsuyoshi Yanagimachi, Jun Honjo, Yukihiro Fujita, Yuichi Makino, Masakazu Haneda

    American Diabetes Association, 74th Scientific Sessions. 

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    Event date: 2014.6

    Language:English   Presentation type:Poster presentation  

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  • 糖尿病性腎症に対するLuseogliflozinの腎保護効果についての検討.

    滝山 由美, 前田 愛実, Kuralay, K. Atageldiyeva, 柳町 剛司, 本庄 潤, 藤田 征弘, 牧野 雄一, 羽田 勝計

    第57回日本糖尿病学会年次学術集会. 

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    Event date: 2014.5

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • ヒト近位尿細管細胞におけるMetallothionein(MT)1 発現に対するTGFβ1 の抑制作用機構

    前田 愛実, 滝山 由美

    第25回日本糖尿病性腎症研究会 

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    Event date: 2013.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京  

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  • Renoprotective Effects of Luseogliflozin (TS-071), a Novel SGLT2 inhibitor, in Diabetic db/db Mice International conference

    Yumi Takiyama,他

    The American Society of Nephrology Annual Meeting & Scientific Exposition 

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    Event date: 2013.11

    Language:English   Presentation type:Poster presentation  

    Venue:Atlanta, GA  

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  • Luseogliflozin (TS-071), a Novel SGLT2 inhibitor, Protects Against Diabetic Nephropathy in Diabetic db/db Mice International conference

    Y. Takiyama, 他

    The European Association for the Study of Diabetes, 49th Annual Meeting 

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    Event date: 2013.9

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Barcelona, Spain  

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  • 近位尿細管細胞SGLT2 発現に対する TGF-β1 の抑制効果について

    滝山 由美

    第28回日本糖尿病合併症学会 

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    Event date: 2013.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

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  • 糖尿病性腎症とIGFBP-rP1 .

    滝山 由美, 渡邊 淳, 羽田 勝計

    第28回日本糖尿病合併症学会. 

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    Event date: 2013.9

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

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  • 糖尿病性腎症とIGFBP-rP1

    滝山 由美, 渡邊 淳, 羽田 勝計

    第28回日本糖尿病合併症学会 

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    Event date: 2013.9

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:旭川  

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  • 近位尿細管細胞SGLT2 発現に対するTGF-β1 の抑制効果について.

    滝山 由美, 前田 愛実, 柳町 剛司, 橘内 博哉, 本庄 潤, 藤田 征弘, 牧野 雄一, 羽田 勝計

    第28回日本糖尿病合併症学会. 

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    Event date: 2013.9

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • In Vivo Imaging of Pancreatic Islets and Kidney Glomeruli in Diabetes

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    Event date: 2013.7

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

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  • 糖尿病における膵島、腎糸球体の 非侵襲的生体可視化法の開発.

    滝山 由美

    第41回可視化情報シンポジウム. 

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    Event date: 2013.7

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

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  • TGF-β1 Inhibits Sodium-Glucose Cotransporter 2 (SGLT2) Expression in Human Renal Proximal Cells International conference

    Kumiko Agatsuma, Yumi Takiyama, 他

    American Diabetes Association, 73rd Scientific Sessions 

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    Event date: 2013.6

    Language:English   Presentation type:Poster presentation  

    Venue:Chicago, IL  

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  • 糖尿病腎症尿細管細胞におけるSGLT2発現制御機構についての検討.

    我 妻 久美子, 滝山 由美, 柳町 剛司, 橘内 博哉, 新井 美成, 永島 優樹, 坂上 英充, 辻 賢, 石関 哉生, 本庄 潤, 藤田 征弘, 安孫子 亜津子, 羽田 勝計

    第56回日本糖尿病学会年次学術集会 

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    Event date: 2013.5

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • 糖尿病腎症尿細管細胞におけるSGLT2発現制御機構についての検討

    我 妻 久美子, 滝山 由美, 柳町 剛司, 橘内 博哉, 新井 美成, 永島 優樹, 坂上 英充, 辻 賢, 石関 哉生, 本庄 潤, 藤田 征弘, 安孫子 亜津子, 羽田 勝計

    第56回日本糖尿病学会年次学術集会 

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    Event date: 2013.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:熊本  

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  • 糖尿病腎症とIGFBP7

    滝山 由美, 渡邊 淳, 羽田 勝計

    第2回教育研究推進センターシンポジウム 

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    Event date: 2013.5

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • 2型糖尿病患者尿中Insulin-like Growth Factor Binding Protein-related Protein 1(IGFBP-rP1)値と腎機能との関連

    滝山 由美, 新井 美成, 永島 優樹, 坂上 英充, 辻 賢, 石関 哉生, 本庄 潤, 藤田 征弘, 安孫子 亜津子, 羽田 勝計

    第24 回 日本糖尿病性腎症研究会 

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    Event date: 2012.12

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • 経過観察中preclinicalCushing'sdiseaseが明らかとなった2型糖尿病の1例

    滝山 由美, 新井 美成, 柳町 剛司, 橘内 博哉, 永島 優樹, 辻 賢, 坂上 英充, 石関 哉生, 藤田 征弘, 安孫子 亜津子, 羽田 勝計

    第46回 日本糖尿病学会北海道地方会 

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    Event date: 2012.11

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • 新規糖尿病性腎症関連分子Metallothionein発現制御機構について

    滝山 由美, 小林 愛実, 本庄 潤, 藤田 征弘, 柳町 剛司, 橘内 博哉, 牧野 雄一, 羽田 勝計

    第27回日本糖尿病合併症集会 

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    Event date: 2012.11

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • HIF-1α as a Novel Molecular Target in Anticancer Effects of Metformin International conference

    Yumi Takiyama, Jun Honjo, Yukihiro Fujita, Tsuyoshi Yanagimachi, Hiroya Kitsunai, Hidemitsu Sakagami, Yuichi Makino, Masakazu Haneda

    American Diabetes Association. 72nd scientific sessions  American Diabetes Association

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    Event date: 2012.6

    Language:English   Presentation type:Poster presentation  

    Venue:Philadelphia, PA, USA  

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  • 新規糖尿病性腎症関連分子Metallothionein発現についての検討

    小林 愛実, 滝山 由美, 藤田 征弘, 本庄 潤, 新井 美成, 柳町 剛司, 橘内 博哉, 永島 優樹, 坂上 英充, 辻 賢, 石関 哉生, 安孫子 亜津子, 牧野 雄一, 羽田 勝計

    第55回日本糖尿病学会学術集会  日本糖尿病学会

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    Event date: 2012.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜  

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  • シンポジウム、糖尿病性腎症におけるメトホルミンの保護効果:HIF-1α発現と酸素代謝における役割

    滝山 由美, 羽田 勝計

    第26回日本糖尿病・肥満動物学会年次学術集会 

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    Event date: 2012.2

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:愛知県  

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  • 糖尿病性腎症尿細管細胞におけるMetallothioneinの発現増強

    滝山 由美, 小林 愛実, 藤田 征弘, 本庄 潤, 柳町 剛司, 橘内 博哉, 坂上 英充, 安孫子 亜津子, 牧野 雄一, 羽田 勝計

    第23回日本糖尿病性腎症研究会  日本糖尿y病性腎症研究会

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    Event date: 2011.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京  

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  • Metallothionein Overexpression May Underlie Tubular Injury in Type 2 Diabetic Nephropathy. International conference

    Yumi Takiyama, Manami Kobayashi, Yukihiro Fujita, Yasutaka Takeda, Jun Honjo, Tsuyoshi Yanagimachi, Hiroya Kitsunai, Hidemitu Sakagami, Yuichi Makino, Masakazu Haneda

    The American Society of Nephrology 44th Annual Meeting & Scientific Exposition,  The American Society of Nephrology

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    Event date: 2011.11

    Language:English   Presentation type:Poster presentation  

    Venue:Philadelphia, PA, USA  

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  • 2型糖尿病性腎症モデルラット尿細管細胞におけるMetallothioneinの発現増強

    滝山 由美, 藤田 征弘, 竹田 安孝, 柳町 剛司, 本庄 潤, 橘内 博哉, 坂上 英充, 牧野 雄一, 羽田 勝計

    第26回日本糖尿病合併症学会  日本糖尿病合併症学会

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    Event date: 2011.10

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:埼玉県さいたま市 大宮  

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  • Dysregulation of Metallothionein in a Rat Model of Type 2 Diabetic Nephropathy: Divergent Roles of Hypoxia and TGF-β1 International conference

    Manami Kobayashi, Yumi Takiyama, Yukihiro Fujita, Jun Honjo, Yasutaka Takeda, Hiroya Kitsunai, Hidemitsu Sakagami, Yuichi Makino, Masakazu Haneda

    American Diabetes Association, 71st Scientific Sessions  American Diabetes Association

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    Event date: 2011.6

    Language:English   Presentation type:Poster presentation  

    Venue:San Diego, CA, USA  

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  • 右副腎腺腫合併のpreclinical Cushings diseaseの一例

    滝山 由美, 安孫子 亜津子, 藤田 征弘, 羽田 勝計

    第20回臨床内分泌代謝update 

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    Event date: 2011.1

    Language:Japanese   Presentation type:Poster presentation  

    Venue:札幌  

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  • 2型糖尿病に伴うNAFLD/NASHにおけるオートファージーシステム効率の低下

    滝山 由美, 岡田 充巧, 柳町 剛司, 永島 優樹, 坂上 英充, 石関 哉生, 藤田 征弘, 安孫子 亜津子, 三代川 斉之, 羽田 勝計

    第44回日本糖尿病学会北海道地方会 

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    Event date: 2010.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:札幌  

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  • Renal Tubulointerstitial Fibrosis in Type 2 Diabetic Rats is Prevented by Metformin: A Possible Role of HIF-1a Expression and Oxygen Metabolism International conference

    Yumi Takiyama, Jun Watanabe, Tatsuo Harumi, Yukihiro Fujita, Jun Honjo, Norihiko Shimizu, Yuichi Makino, Yasutaka Takeda, Masakazu Haneda

    American Diabetes Association. 70th scientific sessions 

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    Event date: 2010.6

    Language:English   Presentation type:Poster presentation  

    Venue:Orlando, FL  

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  • メトホルミンは、ミトコンドリアと酸化ストレスを標的として、糖尿病性腎症を改善する

    滝山 由美, 渡邊 淳, 藤田 征弘, 本庄 潤, 牧野 雄一, 羽田 勝計

    第53回日本糖尿病学会年次学術集会 

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    Event date: 2010.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岡山  

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  • Insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1)は、Epithelial Mesenchymal Transition(EMT)を介し、腎症進展に関与する

    渡邊 淳, 滝山 由美, 本庄 潤, 坂上 英充, 牧野 雄一, 立野 正敏, 羽田 勝計

    第53回日本糖尿病学会年次学術集会 

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    Event date: 2010.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岡山  

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  • Metformin Inhibits HIF-1α Expression in Human Renal Proximal Tubular Epithelial Cell through Inhibition of Mitochondrial Respiration. International conference

    Yumi Takiyama, Tatsuo Harumi, Jun Watanabe, Yukihiro Fujita, Norihiko Shimizu, Yuichi Makino, Masakazu Haneda

    International Society of Nephrolog (ISN) Nexus 

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    Event date: 2010.4

    Language:English   Presentation type:Poster presentation  

    Venue:Kyoto, Japan  

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  • Metformin Inhibits HIF-1α Expression in Human Anaplastic Thyroid Cancer Cells by Suppressing Mitochondrial Respiration. International conference

    Yumi Takiyama, Yukihiro Fujita, Masakazu Haneda

    14th International Congress of Endocrinology 

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    Event date: 2010.3

    Language:English   Presentation type:Poster presentation  

    Venue:Kyoto, Japan  

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  • symposium, Pathogenesis of diabetic nephropathy: Role of hypoxia-inducible factor-1α(HIF-1α) International conference

    Masakazu Haneda, Yuichi Makino, Yumi Takiyama

    14th International Congress of Endocrinology 

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    Event date: 2010.3

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Venue:Kyoto, Japan  

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  • LC-MS/MS-based proteomic analysis of the proteins secreted by human renal proximal tubular epithelia cells (HRPTEC) reveals IGFBP-rP1 as a potential proteomic biomarker associated with diabetic nephropathy (DN). International conference

    Yumi Takiyama, Jun Watanabe, Jun Honjyo, Hidemitsu Sakagami, Yuichi Makino, Yasutaka Takeda, Yukihiro Fujita, Masatoshi Tateno, Masakazu Haneda

    The American Society of Nephrology 42nd Annual Meeting & Scientific Exposition, 

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    Event date: 2009.10

    Language:English   Presentation type:Poster presentation  

    Venue:San Diego, LA.  

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  • Insulin-like growth factor binding protein-related protein 1(IGFBP-rP1)の糖尿病性腎症新規尿細管障害バイオマーカーとしての可能性について

    渡邊 淳, 滝山 由美, 本庄 潤, 坂上 英充, 牧野 雄一, 竹田 安考, 藤田 征弘, 立野 正敏, 羽田 勝計

    第24回日本糖尿病合併症学会 

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    Event date: 2009.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岡山  

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  • Insulin-like Growth Factor Binding Protein-related Protein 1 (IGFBP-rP1) as a Possible Biomarker of Proximal Tubule Injury in Type-2 Diabetic Patients with Proteinuria International conference

    Jun Watanabe, Yumi Takiyama, Jun Honjyo, Hidemitsu Sakagami, Yuichi Makino, Yasutaka Takeda, Yukihiro Fujita, Masatoshi Tateno, Masakazu Haneda

    American Diabetes Association. 69th scientific sessions 

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    Event date: 2009.6

    Language:English   Presentation type:Poster presentation  

    Venue:New Orleans, LA  

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  • シンポジウム、 メトホルミンの尿細管細胞保護作用.「糖尿病性腎症を探る~上皮細胞・尿細管異常の面から~」

    滝山 由美, 羽田 勝計

    第52回日本糖尿病学会年次学術集会 

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    Event date: 2009.5

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:大阪  

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  • 糖尿病性腎症における新規尿細管障害バイオマーカーinsulin-like growth factor binding protein-related protein 1(IGFBP-rP1)についての検討

    渡邊 淳, 滝山 由美, 藤田 征弘, 本庄 潤, 磯江 つばさ, 坂上 英充, 竹田 安考, 辻 賢, 入宇田 能弥, 石関 哉生, 安孫子 亜津子, 伊藤 博史, 立野 正敏, 羽田 勝計

    第52回日本糖尿病学会年次学術集会 

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    Event date: 2009.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪  

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  • 2型糖尿病性腎症腎におけるIL-18発現増強:TGF-βは、MAPKを介してIL-18発現を増強する

    滝山 由美, 宮内 和誠, 本庄 潤, 立野 正敏, 羽田 勝計

    第82回日本内分泌学会学術総会 

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    Event date: 2009.4

    Language:Japanese   Presentation type:Poster presentation  

    Venue:前橋  

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  • ヒト甲状腺未分化癌細胞(ARO cell)におけるHIF-1α発現制御機構.

    滝山 由美, 青木 直子, 羽田 勝計

    第51回日本甲状腺学会学術集会 

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    Event date: 2008.11

    Language:Japanese   Presentation type:Poster presentation  

    Venue:前橋  

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  • Metformin attenuates the profibrotic response induced by TGF-β1 in human renal proximal tubular cells(HRPTECs) International conference

    Yumi Takiyama, Jun Watanabe, Jun Honjyo, Tsubasa Isoe, Hidemitu Sakagami, Yuichi Makino, Yukihiro Fujita, Masakazu Haneda

    The American Society of Nephrology 41st Annual Meeting & Scientific Exposition 

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    Event date: 2008.11

    Language:English   Presentation type:Poster presentation  

    Venue:Philadelphia, PA  

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  • TGF-β1 upregulates insulin-like growth factor binding protein (IGFBP)-7 expression in human renal proximal tubular epithelial cell (HRPTEC) International conference

    Jun Watanabe, Yumi Takiyama, Jun Honjyo, Tsubasa Isoe, Hidemitsu Sakagami, Yuichi Makino, Yukihiro Fujita, Masakazu Haneda

    The European Association for the Study of Diabetes, 44th Annual Meeting 

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    Event date: 2008.9

    Language:English   Presentation type:Poster presentation  

    Venue:Roma, Italy  

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  • Metformin inhibits the expressions of HIF-1α and PAI-1 through the inhibition of mitochondrial respiratory chain complex I in human renal proximal tubular epithelial cells (HRPTECs) in Culture International conference

    Yumi Takiyama, Jun Watanabe, Jun Honjyo, Tsubasa Isoe, Hidemitu Sakagami, Yukihiro Fujita, Yuichi Makino, Masakazu Haneda

    American Diabetes Association, 68th scientific sessions 

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    Event date: 2008.6

    Language:English   Presentation type:Poster presentation  

    Venue:San Francisco, CA  

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  • メトホルミンは、ヒト尿細管培養細胞におけるHIF-1α蛋白発現を抑制する

    滝山 由美, 渡邊 淳, 本庄 潤, 磯江 つばさ, 坂上 英充, 竹田 安考, 佐藤 則和, 入宇田 能弥, 石関 哉生, 安孫子 亜津子, 藤田 征弘, 伊藤 博史, 羽田 勝計

    第51回日本糖尿病学会年次学術集会 

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    Event date: 2008.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京  

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  • メトホルミンは、ヒト尿細管培養細胞におけるHIF-1α蛋白発現を抑制する

    滝山 由美, 渡邊 淳, 本庄 潤, 磯江 つばさ, 牧野 雄一, 羽田 勝計

    第19回日本糖尿病性腎症研究会 

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    Event date: 2007.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京  

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  • AMPキナーゼ(AMPK)による甲状腺未分化癌細胞におけるHIF-1α 発現抑制作用

    滝山 由美, 青木 直子, 羽田 勝計

    第50回日本甲状腺学会学術集会 

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    Event date: 2007.11

    Language:Japanese   Presentation type:Poster presentation  

    Venue:神戸  

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  • Metformin inhibits the expression of HIF-1α and PAI-1 in human renal proximal tubular epithelial cells (HRPTEC) in culture. International conference

    Yumi Takiyama, Jun Honjyo, Jun Watanabe, Tsubasa Isoe, Kensaku Okamoto, Yuichi Makino, Masakazu Haneda

    The American Society of Nephrology 40th Annual Meeting & Scientific Exposition 

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    Event date: 2007.10 - 2007.11

    Language:English   Presentation type:Poster presentation  

    Venue:San Francisco, CA  

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  • シンポジウム、メトホルミンの糖尿病性腎症治療薬としての可能性

    滝山 由美, 羽田 勝計

    第22回日本糖尿病合併症学会 

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    Event date: 2007.10

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:つくば  

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  • A new strategy for anaplastic thyroid carcinoma: metformin inhibits HIF-1α expression in human anaplastic thyroid cancer cells International conference

    Yumi Takiyama, Naoko Aoki, Masakazu Haneda

    American Thyroid Association 78th Annual Meeting 

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    Event date: 2007.10

    Language:English   Presentation type:Poster presentation  

    Venue:New York, NY.  

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  • 糖尿病性腎症におけるメトホルミンの腎保護作用について

    滝山 由美, 本庄 潤, 牧野 雄一, 宮内 和誠, 磯江 つばさ, 渡邊 淳, 石関 哉也, 上堀 勢位嗣, 安孫子 亜津子, 伊藤 博史, 羽田 勝計

    第50回日本糖尿病学会年次学術集会 

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    Event date: 2007.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:仙台  

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  • Proteasome inhibitor による甲状腺未分化癌細胞のapoptosis誘導作用

    滝山 由美, 青木 直子, 菅原 明, 伊藤 公一, 羽田 勝計

    第49 回日本甲状腺学会学術集会 

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    Event date: 2006.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:高松  

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  • The proteasome inhibitors induce apoptosis of anaplastic thyroid cancer cells International conference

    Yumi Takiyama, Naoko Aoki, Koichi Ito, Masakazu Haneda

    American Thyroid Association, 77th Annual Meeting 

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    Event date: 2006.10

    Language:English   Presentation type:Poster presentation  

    Venue:Phoenix, AZ  

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  • Interluekin-18(IL-18) expression is up-regulated in renal tubular cells in type 2 diabetic subjects with nephropathy. International conference

    Yumi Takiyama, Kazunari Miyauchi, Jun Honjyo, Seiji Uebori, Tsubasa Isoe, Atsuko Abiko, Hiroshi Itoh, Masatoshi Tateno, Masakazu Haneda

    American Diabetes Association, 66th Scientific Sessions 

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    Event date: 2006.6

    Language:English   Presentation type:Poster presentation  

    Venue:Washington, DC, MD  

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  • 糖尿病性腎症におけるIL-18の役割

    宮内 和誠, 滝山 由美, 上堀 勢位嗣, 本庄 潤, 磯江 つばさ, 安孫子 亜津子, 伊藤 博史, 三代川 斉之, 佐藤 英俊, 立野 正敏, 羽田 勝計

    第17回日本糖尿病性腎症研究会 

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    Event date: 2005.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京  

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  • 甲状腺癌細胞におけるproteasome inhibitorの抗腫瘍効果

    滝山 由美, 三代川 斉之, 菅原 明, 伊藤 公一, 羽田 勝計

    第48回日本甲状腺学会学術集会 

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    Event date: 2005.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京  

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  • 糖尿病性腎症・進展に関与する免疫学的機構の解明:IL-18の役割

    上堀 勢位嗣, 滝山 由美, 本庄 潤, 石関 哉生, 宮内 和誠, 柏谷 朋, 安孫子 亜津子, 網頭 慶太, 三代川 斉之, 佐藤 英俊, 立野 正敏, 羽田 勝計

    第48回日本糖尿病学会年次学術集会 

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    Event date: 2005.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸.  

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  • 甲状腺癌におけるRetinoid X Receptor (RXR) isoformの発現と局在

    滝山 由美, 三代川 斉之, 菅原 明, 伊藤 公一, 佐藤 啓介, 立野 正敏, 羽田 勝計

    第47回日本甲状腺学会学術集会 

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    Event date: 2004.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:前橋  

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  • Enhanced IL-18 expression in papillary thyroid carcinomas International conference

    Yumi Takiyama, Naoyuki Miyokawa, Koichi Ito, Keisuke Sato, Masatoshi Tateno, Masakazu Haneda

    American Thyroid Association 76th Annual Meeting 

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    Event date: 2004.9 - 2004.10

    Language:English   Presentation type:Poster presentation  

    Venue:Vancouver, Canada  

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  • 甲状腺乳頭癌におけるIL-18発現増強.

    滝山 由美, 三代川 斉之, 伊藤 公一, 佐藤 啓介, 立野 正敏

    第77回日本内分泌学会学術総会 

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    Event date: 2004.6

    Language:Japanese   Presentation type:Poster presentation  

    Venue:京都  

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  • ヒト甲状腺癌におけるIL-18発現増強

    滝山 由美, 三代川 斉之, 伊藤 公一, 佐藤 啓介, 及川 賢輔, 小林 博也, 木村 昭治, 立野 正敏

    第93回日本病理学会 

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    Event date: 2004.6

    Language:Japanese   Presentation type:Poster presentation  

    Venue:札幌  

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  • 重症心不全の併発により治療に難渋したBasedow病の1例

    滝山 貴央, 橘内 博哉, 早川 弘恵, 平間 凜, 山縣 二美可, 佐々木 大河, 滝山 侑里, 沖崎 貴琢, 滝山 由美

    第23回 日本内分泌学会北海道支部学術集会 

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    Language:Japanese   Presentation type:Oral presentation (general)  

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Awards

  • 第39回日本甲状腺学会学術総会 会長賞

    1996.10   日本甲状腺学会  

    滝山 由美

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

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Research Projects

  • Diabetic Circulatory Disorder

    Grant number:22K08301  2022.4 - 2025.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Grant amount:\4,160,000 ( Direct Cost: \3,200,000 、 Indirect Cost:\960,000 )

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  • Fetal overnutrition induced fast progression of diabetic kidney disease

    Grant number:19K08718  2019.4 - 2022.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    TAKIYAMA YUMI

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    Grant amount:\4,290,000 ( Direct Cost: \3,300,000 、 Indirect Cost:\990,000 )

    Maternal overnutrition induced a significant increase in renal volume in the fetuses. On the other hand, there was no significant difference in the diameter of the renal artery in the fetuses between the control diet (CD)-fed dams and high-fat diet (HFD)-fed dams. Murray's law indicates that organ blood flow is proportional to arterial diameter (Murray CD. Proc Natl Acad Sci USA 1926), suggesting that fetal kidneys in the HFD group have reduced blood flow because of concomitant renal hypertrophy. Immunohistochemical staining of HIF-1α, which is an index of hypoxia, showed enhanced expression of HIF-1α in the fetal kidneys in the HFD group. There was no significant difference in urinary albumin excretion between the two groups at 15 weeks of age in the offspring, but vacuolar formation was observed in the renal tubular cells of the HFD group at 4 weeks of age. In addition, at 15 weeks of age, renal glomerular sclerosis and arteriosclerosis of the glomerular arteries were observed.

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  • Metallothionein 3: A New Player in Diabetic Nephropathy

    Grant number:15K09372  2015.4 - 2018.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    TAKIYAMA YUMI

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    Grant amount:\4,940,000 ( Direct Cost: \3,800,000 、 Indirect Cost:\1,140,000 )

    We hypothesized that metallothionein 3 (MT3), a novel target gene of hypoxia inducible factor-1 (HIF-1), could be involved in the diabetic glomerular injury in a retrograde fashion, via hyperglycemia-induced hypoxia in renal proximal tubules accompanied with overexpression of MT3. To clarify the role of MT3 in diabetic kidney, we generated transgenic mice, harboring a 40-kb bacterial artificial chromosome (BAC) expressing human MT3 mRNA and protein to generate humanized BAC transgenic mice (BACTGMT3). Aging-, diabetes- and high fat-induced hypoxia induced overexpression of MT3 in tubular cells in BACTGMT3 mice, resulting in narrowing the vascular lumen of peritubular capillaries by the endothelial swelling, which could retrogradely cause glomerular hypertension, leading to the glomerular injury.

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  • 糖尿病性脳腎連関:MT3/Klotho/Biogenic metallic elementsの役割

    2023.12 - 2024.11

    民間財団等 

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    本研究では、ヒトMT3-Klothoを介した脳内の金属代謝調節とともに、糖尿病腎症とアルツハイマー病の病変をきたす脳と腎臓の間の関連性を明らかとすることを目的としている。

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  • 19116 ギリアド・サイエンス株式会社 中等度から進行した糖尿病性腎臓病の被験者を対象にセロンセルチブの有効性及び安全性を評価する第3相、ランダム化、二重盲検、プラセボ対照、並行群間比較、多施設共同試験 追加配当

    2020.8 - 2022.4

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  • 胎内栄養環境によるNAFLD/NASHと肝癌発症メカニズムの解明

    2016.4 - 2017.3

    民間財団等 

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  • Autophagy as a New Therapeutic Target of the SGLT2 Inhibitor Luseogliflogin in Diabetic Nephropathy.

    2015.1 - 2015.9

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  • SGLT2阻害薬による膵島・腎糸球体保護作用:細小血管構築からの検討

    2014.11 - 2016.8

    民間財団等 

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  • SGLT2阻害薬の腎保護効果について

    2012.7 - 2013.7

    大正製薬株式会社 

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    1.In vitro:ヒト近位尿細管上皮培養細胞(HRPTEC;Lonza社)を用い、高ブドウ糖、Hypoxiaによる細胞障害に対するSGLT2阻害剤の腎保護効果について検討する。
    2.In vivo:Streptozotocin誘発糖尿病ラット、高脂血症、高血圧合併症、2型糖尿病モデルラットZucker Diabetic Fatty Ratを用い、対照比較群、SGLT2阻害剤投与群、インスリン(Linplant)投与群の3群における1型、2型糖尿病性腎症の発展・進展について検討する。

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  • 造影剤腎症におけるメトホルミン効果についての検討

    2011.8 - 2016.3

    (選択しない) 

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  • A drug for diabetic multiple organ complications

    2010.8 - 2011.11

    (選択しない) 

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  • 糖尿病性腎症における新規尿細管障害バイオマーカーinsulin-like growth factor binding protein-related protein 1(IGFBP-rP1)についての検討

    2008.4 - 2016.3

    (選択しない) 

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  • ビグアナイド剤の腎保護作用

    2007.4 - 2008.3

    アステラス製薬株式会社 

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    インスリン抵抗性改善薬であるメトホルミンの糖尿病性腎症における腎保護作用について、ヒト尿細管培養細胞を用い、糖尿病性腎症病態関連分子の発現制御について検討した。メトホルミンは、糖尿病性腎症増悪進展因子であるTGF-β、angiotensin II刺激誘導によるfibrotic factorであるPAI-1、collagen-1,Fibronectin、またchemokine MCP-1の蛋白、mRNAの発現を抑制し、腎保護作用有することが示唆された。

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  • The Renometabolic Syndrome; 糖尿病性腎症進展予防に対する治療戦略標的としてのIL-18

    2007.1 - 2007.12

    キッセイ薬品工業株式会社 

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    糖尿病性腎症組織において発現増強が認められたIL-18の発現制御について、ヒト尿細管培養細胞を用いて検討を進めた。ヒト尿細管培養細胞において、IL-18mRNAは恒常的に発現しており、蛋白発現も確認した。IL-18mRNAの発現はTGF-β1 刺激により濃度依存性に亢進した。ヒト近位尿細管上皮培養細胞におけるTGF-β1刺激によるIL-18mRNAの発現亢進は、PI3K阻害剤であるLY294002前処理により抑制されなかったが、Erk1/2阻害剤であるPD98059、p38 MAPK阻害剤であるSB203580、JNK阻害剤であるSP600125前処理により優位に抑制され、これらMAPK系の活性化を介することが明らかとなった。

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  • Tubular Injury in a Rat Model of Type 2 Diabetes Is Prevented by Metformin

    2006.12 - 2011.3

    (not selected) 

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  • 糖尿病性腎症におけるtelmisartan、pioglitazoneの腎保護効果

    2006.4 - 2016.3

    (選択しない) 

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  • 糖尿病性腎症におけるInterleukin-18の役割

    2004.4 - 2009.2

    (選択しない) 

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  • 甲状腺癌におけるproteosome inhibitorの抗腫瘍効果

    2003.12 - 2006.11

    (選択しない) 

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  • 甲状腺癌におけるretinoid X receptor (RXR) isoforms発現様式

    2002.11 - 2004.11

    (選択しない) 

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  • 自己免疫性甲状腺疾患におけるInterleukin-18の役割

    1996.10 - 2002.12

    共同研究 

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  • 新規免疫担当分子DAP-12

    1996.10 - 1997.10

    (選択しない) 

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  • 抗甲状腺剤の分子生物学的検討

    1995.10 - 1996.10

    伊藤伊藤医薬学術交流財団 

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  • 甲状腺腫瘍のトランスジェニックマウスモデル International coauthorship

    1995.5 - 1996.6

    (選択しない) 

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  • 甲状腺癌のgene therapy International coauthorship

    1995.5 - 1996.6

    (選択しない) 

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  • microsatellite analysisを用いた甲状腺癌LOH の検討 International coauthorship

    1995.5 - 1996.6

    (選択しない) 

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  • 胆汁酸の甲状腺細胞機能、増殖への影響

    1992.4 - 1996.10

    (選択しない) 

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  • 甲状腺細胞機能におけるhydrocortisone、RU486の効果

    1989.4 - 1994.11

    (選択しない) 

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  • 甲状腺細胞の増殖とヨード代謝に対するリチウムの効果についての研究

    1987.5 - 1990.1

    (選択しない) 

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  • ヒト腎糸球体・膵島描出MRI法の開発

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    旭川医科大学病院糖尿病内科、循環器内科、腎臓内科にて、治療中の糖尿病症例、高血圧症例と健常対照群の腹部MRI拡散強調画像を同院放射線医学講座にて通常診療時間内に撮影する。日立製作所中央研究所において開発された解析ソフトウェアを用い、腎糸球体・膵島の描出を試みる。更に、従来からの血液・尿検査等の生化学的検査より得られた腎濾過機能、膵内分泌機能との比較検討によりプログラム改良を進め、腎糸球体・膵島描出MRI画像診断法を確立する。

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  • 寄附金

    日本ベーリンガーインゲルハイム株式会社 

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    Grant amount:\1,000,000

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  • 胎生期栄養に起因する新規非アルコール性脂肪肝炎/肝癌モデルの確立

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  • 毛細血管幹細胞の膵島内神経ネットワーク維持および糖尿病病態への役割解明

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  • 寄附金

    大正製薬株式会社 

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    Grant amount:\2,000,000

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  • 大規模並列計算、機械学習・深層学習によるデータ解析法の開発

    理化学研究所計算科学研究センター、バイオ・ソフトマテリアルグループ 微細構造計測チーム、東北大学 

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    並列計算基盤KMR、機械学習・深層学習等による解析フローの短縮を目的とし、糖尿病腎糸球体セグメンテーション解析に機械学習・深層学習を適用する。これにより、データ解析の半自動化と情報科学との連携を進める。

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  • ポスト「京」重点課題アプリケーション開発. FLAGSHIP2020 Project. サブ課題B「データ同化生体シミュレーションによる個別化医療支援」

    理化学研究所 可視化技術研究チーム・画像処理研究チーム、大阪大学、東京大学、九州大学、東海大学、東北大学、加齢医学研究所、国立刀根山病院、富士通(株) 

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    個体生体機能評価のためのデータ同化シミュレータの開発

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  • In Vivo Imaging of Pancreatic Islets and Renal Glomeruli in Type 2 Diabetic Mice

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  • 2型糖尿病モデルマウスにおける膵ランゲルハンス氏島、腎糸球体の非侵襲的生体可視化法の検討

    共同研究 

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  • SGLT2阻害薬の腎保護効果について

    共同研究 

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  • 胎内栄養環境によるNAFLD/NASHと肝癌発症メカニズムの解明

    (選択しない) 

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  • ヒト腎糸球体・膵島描出MRI法の開発

    (選択しない) 

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    観察研究・
    旭川医科大学病院糖尿病内科にて、治療中の糖尿病症例と健常対照群の腹部MRI拡散強調画像を同院放射線科にて撮影する。日立製作所中央研究所において開発された解析ソフトウェアを用い、腎糸球体・膵島の描出を試みる。更に、従来からの血液・尿検査等の生化学的検査より得られた腎濾過機能、膵内分泌機能との比較検討によりプログラム改良を進め、腎糸球体・膵島描出MRI画像診断法を確立する。

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  • メトホルミンによる抗腫瘍効果:HIF-1発現抑制作用を介して

    (選択しない) 

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  • 新規糖尿病性腎症関連分子Metallothionein発現についての検討

    (選択しない) 

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  • 甲状腺癌におけるInterleukin-18発現

    (選択しない) 

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Social Activities

  • 派遣講座:東神楽町高齢者大学 あやめ学園「4月学習」

    2022.4

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    糖尿病:予防と治療

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  • 派遣講座:上川管内市町村保健活動連絡協議会

    2022.2

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    甲状腺の病気

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  • 派遣講座:糖尿病重症化予防健康講話(雄武町)

    2018.11

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    雄武町民センター 2階会議室にて、健診結果でHbA1c5.6以上の人、または希望者を対象に1時間半、糖尿病と合併症についての講演とその後の質疑応答。

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  • 派遣講座:北海道上川総合振興局 生活習慣病予防セミナー

    2011.11

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  • 病院薬剤師会学術講演会 「北海道腎と薬剤研究会」

    2011.10

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  • 北都保健福祉専門学校講師

    2009.4 - 2021.4

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  • 派遣講座::北海道臨床衛生検査技師会 生理機能談話会 「甲状腺のABC」

    2009.2

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  • 第6回旭川医師会女性医師部会 市民講演会「女性に多い甲状腺疾患:内科医の立場から」

    2008.7

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  • 派遣講座:深川医療連携地域講座 「甲状腺疾患の診断と治療」

    2008.6

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Academic Activities

  • 第97回日本内分泌学会学術総会

    Role(s): Panel moderator, session chair, etc.

    2024.6

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  • Journal of Diabetes Investigation 査読 International contribution

    2023.10 - 2024.2

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  • Journal of Diabetes Investigation 査読

    2023.7 - 2023.8

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  • 第66回日本糖尿病学会年次学術集会 一般演題座長

    2023.5

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  • PLOS ONE査読 International contribution

    2023.2 - 2023.5

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  • Journal of Diabetes Investigation 査読

    2023.2

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  • Scientific Reports 査読 International contribution

    2022.10 - 2023.4

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  • 第65回日本糖尿病学会年次学術集会 若手研究奨励賞審査口演座長

    2022.5

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  • 日本糖尿病学会 「Diabetology International」編集委員

    2022.5

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  • Scientific Research 査読 International contribution

    2022.4 - 2022.5

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  • 日本糖尿病学会 若手研究奨励賞(YIA)委員会 審査委員

    2022.4

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  • Jouranl of Diabetes Investigation 論文査読 International contribution

    2022.2 - 2022.3

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  • アメリカ内分泌学会(ENDO 2022) Abstract Reviewer International contribution

    2021.12 - 2022.2

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  • 第293回日本内科学会北海道地方会 幹事

    2021.11

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  • 第55回日本糖尿病学会北海道地方会 会長

    2021.10

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  • 第21回日本内分泌学会北海道地方会 会長

    2021.10

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  • ENDO 2021(米国内分泌学会学術会議) 抄録査読 International contribution

    2020.11

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  • 日本内科学会北海道支部主催 第62回生涯教育講演会 幹事

    2019.11

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  • 一般社団法人 日本糖尿病学会 評議員

    2019.5

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    Type:Academic society, research group, etc. 

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  • 第30回日本糖尿病性腎症研究会 一般口演座長

    2018.12

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  • 第52回日本糖尿病学会北海道地方会 一般演題 座長

    2018.11

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    【教員評価対象外項目:地方学会】

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  • 日本内分泌学会北海道支部幹事

    2017.11

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    【教員評価対象外項目:地方学会】

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  • Clinical and Experimental Nehrology 査読 International contribution

    2017.8 - 2017.9

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  • 第60回日本糖尿病学会学術集会 一般口演座長

    2017.5

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  • 第90回日本内分泌学会学術総会 シンポジウム座長

    2017.4

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  • 第26回日本糖尿病性腎症研究会 一般口演演題座長

    2016.12

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  • 第15回日韓糖尿病性腎症セミナー 口演演題座長 International contribution

    2016.10

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  • 第59回日本糖尿病学会年次学術集会 一般ポスター演題座長

    2016.5

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  • 第89回日本内分泌学会学術総会 一般ポスター演題座長

    2016.4

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  • 第58回日本糖尿病学会年次学術集会 一般口演演題座長

    2015.5

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  • 第26回日本内科学会北海道地方会一般演題座長

    2013.2

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  • 第24回日本糖尿病性腎症研究会一般演題座長

    2012.12

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  • 第9回国際糖尿病連合西太平洋地区会議(9th IDF-WPR Congress)一般演題セッション座長 International contribution

    2012.11

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  • 第46回日本糖尿病学会北海道地方会「専門医更新のための指定講演」座長

    2012.11

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  • 第55回日本糖尿病学会年次学術集会 一般口演発表座長

    2012.5

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  • 第54回日本糖尿病学会年次学術集会 ポスター発表座長

    2011.5

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  • 第54回日本糖尿病学会学術集会 学会事務局実行委員

    2011.5

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  • 女性医師専門医育成・再教育委員会(Jes We Can: Japan Endocrine Society Women Endocrinologist Association 北海道支部会担当委員

    2010.12

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    【教員評価対象外項目:地方学会】

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  • 日本内分泌学会 評議員

    2010.4

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  • 14th International Congress of Endocrinology ポスターセッション座長 International contribution

    2010.3

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  • 第17回臨床内分泌代謝update ポスターセッション座長

    2007.3

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  • Journal of Proteomics 査読 International contribution

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  • Clinical Endocrinology 査読 International contribution

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  • Diabetes Research and Clinical Practice査読 International contribution

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  • Experimental Diabetes Research査読 International contribution

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  • Naunyn-Schmiedeberg's Archives of Pharmacology 査読 International contribution

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  • Internal Medicine 査読 International contribution

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  • Diabetes 査読 International contribution

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  • PLOS ONE査読 International contribution

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  • Endocrine Jounal査読 International contribution

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  • Clinical and Experimental Nephrology査読 International contribution

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  • Advances in Therapy査読 International contribution

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