Updated on 2024/12/04

写真a

 
KAWABE Jun-ichi
 
Organization
President /Vice-President

Degree

  • 博士(医学) ( 1991.3   旭川医科大学 )

Research Interests

  • stem cells

  • pericytes

  • Angiogenesis

Research Areas

  • Life Science / Cell biology  / 再生医学 血管新生 神経再生

  • Life Science / Pathological biochemistry

  • Life Science / Cardiology  / 再生医療 動脈硬化 血管新生 

Education

  • Asahikawa Medical College   Graduate School, Division of Medicine

    - 1991.3

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    Country: Japan

  • Asahikawa Medical College   Faculty of Medicine

    - 1987.3

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    Country: Japan

Research History

  • Asahikawa Medical College   Professor

    2019.6

Professional Memberships

  • JSRM

    2015.4

  • 日本心脈管作動物質学会

    2000.4

Papers

  • Pericyte-specific deletion of ninjurin-1 induces fragile vasa vasorum formation and enhances intimal hyperplasia of injured vasculature. Reviewed

    Horiuchi, K. Kano, K. Minoshima, A. Hayasaka, T. Yamauchi, A. Tatsukawa, T. Matsuo, R. Yoshida, Y. Tomita, Y. Kabara, M. Nakagawa, N. Takehara, N. Hasebe, N. Kawabe, J. I.

    Am J Physiol Heart Circ Physiol.   320 ( 6 )   H2438 - H2447   2021.5

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1152/ajpheart.00931.2020

  • EphA7(+) perivascular cells as myogenic and angiogenic precursors improving skeletal muscle regeneration in a muscular dystrophic mouse model Reviewed

    Kano, K. Horiuchi, K. Yoshida, Y. Hayasaka, T. Kabara, M. Tomita, Y. Tatsukawa, T. Matsuo, R. Sawada, J. Nakagawa, N. Takehara, N. Hasebe, N. Kawabe, J. I.

    Stem Cell Res   47   10194   2020.8

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.scr.2020.101914

  • Capillary-resident EphA7+ pericytes are multipotent cells with anti-ischemic effects through capillary formation

    Yoshida, Y. and Kabara, M. and Kano, K. and Horiuchi, K. and Hayasaka, T. and Tomita, Y. and Takehara, N. and Minoshima, A. and Aonuma, T. and Maruyama, K. and Nakagawa, N. and Azuma, N. and Hasebe, N. and Kawabe, J.-I.

    Stem Cells Translational Medicine   9 ( 1 )   120 - 130   2020

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/sctm.19-0148

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  • Ninjurin 1 mediates peripheral nerve regeneration through Schwann cell maturation of NG2-positive cells

    Tomita, Y. and Horiuchi, K. and Kano, K. and Tatsukawa, T. and Matsuo, R. and Hayasaka, T. and Yoshida, Y. and Kabara, M. and Yasuda, S. and Nakajima, K. and Nakagawa, N. and Takehara, N. and Okizaki, A. and Hasebe, N. and Kawabe, J.-I.

    Biochemical and Biophysical Research Communications   519 ( 3 )   462 - 468   2019

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2019.09.007

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  • The antioxidant and DNA-repair enzyme apurinic/apyrimidinic endonuclease 1 limits the development of tubulointerstitial fibrosis partly by modulating the immune system

    Maruyama, K. and Nakagawa, N. and Aonuma, T. and Saito, Y. and Hayasaka, T. and Kano, K. and Horiuchi, K. and Takehara, N. and Kawabe, J.-I. and Hasebe, N.

    Scientific Reports   9 ( 1 )   7823   2019

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-019-44241-z

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  • A 3D in vitro pericyte-supported microvessel model: Visualisation and quantitative characterisation of multistep angiogenesis

    Lee, E. and Takahashi, H. and Pauty, J. and Kobayashi, M. and Kato, K. and Kabara, M. and Kawabe, J.-I. and Matsunaga, Y.T.

    Journal of Materials Chemistry B   6 ( 7 )   1085 - 1094   2018

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/c7tb03239k

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  • Pericyte-specific ninjurin1 deletion attenuates vessel maturation and blood flow recovery in hind limb ischemia

    Minoshima, A. and Kabara, M. and Matsuki, M. and Yoshida, Y. and Kano, K. and Tomita, Y. and Hayasaka, T. and Horiuchi, K. and Saito, Y. and Aonuma, T. and Nishimura, M. and Maruyama, K. and Nakagawa, N. and Sawada, J. and Takehara, N. and Hasebe, N. and Kawabe, J.-I.

    Arteriosclerosis, Thrombosis, and Vascular Biology   38 ( 10 )   2358 - 2370   2018

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/ATVBAHA.118.311375

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  • Apoptosis-resistant cardiac progenitor cells modified with apurinic/apyrimidinic endonuclease/ redox factor 1 gene overexpression regulate cardiac repair after myocardial infarction

    Aonuma, T. and Takehara, N. and Maruyama, K. and Kabara, M. and Matsuki, M. and Yamauchi, A. and Kawabe, J.-I. and Hasebe, N.

    Stem Cells Translational Medicine   5 ( 8 )   1067 - 1078   2016

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.5966/sctm.2015-0281

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  • Ninjurin1 is a novel factor to regulate angiogenesis through the function of pericytes

    Matsuki, M. and Kabara, M. and Saito, Y. and Shimamura, K. and Minoshima, A. and Nishimura, M. and Aonuma, T. and Takehara, N. and Hasebe, N. and Kawabe, J.-I.

    Circulation Journal   79 ( 6 )   1363 - 1371   2015

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1253/circj.CJ-14-1376

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  • Prostaglandin I2 analog suppresses lung metastasis by recruiting pericytes in tumor angiogenesis

    Minami, Y. and Sasaki, T. and Bochimoto, H. and Kawabe, J.-I. and Endo, S. and Hira, Y. and Watanabe, T. and Okumura, S. and Hasebe, N. and Ohsaki, Y.

    International Journal of Oncology   46 ( 2 )   548 - 554   2015

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3892/ijo.2014.2783

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  • Association between microalbuminuria predicting in-stent restenosis after myocardial infarction and cellular senescence of endothelial progenitor cells

    Ota, H. and Takehara, N. and Aonuma, T. and Kabara, M. and Matsuki, M. and Yamauchi, A. and Takeuchi, T. and Kawabe, J.-I. and Hasebe, N.

    PLoS ONE   10 ( 4 )   e0123733   2015

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0123733

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  • Impaired glutathione redox system paradoxically suppresses angiotensin II-induced vascular remodeling

    Izawa, K. and Okada, M. and Sumitomo, K. and Nakagawa, N. and Aizawa, Y. and Kawabe, J. and Kikuchi, K. and Hasebe, N.

    PLoS ONE   9 ( 10 )   e108115   2014

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0108115

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  • Immortalized multipotent pericytes derived from the vasa vasorum in the injured vasculature. A cellular tool for studies of vascular remodeling and regeneration

    Kabara, M. and Kawabe, J.-I. and Matsuki, M. and Hira, Y. and Minoshima, A. and Shimamura, K. and Yamauchi, A. and Aonuma, T. and Nishimura, M. and Saito, Y. and Takehara, N. and Hasebe, N.

    Laboratory Investigation   94 ( 12 )   1340 - 1354   2014

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/labinvest.2014.121

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  • Initial reduction of oxidative stress by angiotensin receptor blocker contributes long term outcomes after percutaneous coronary intervention

    Noro, T. and Takehara, N. and Sumitomo, K. and Takeuchi, T. and Ishii, Y. and Kato, J.-I. and Kawabe, J.-I. and Hasebe, N.

    American Journal of Cardiovascular Disease   4 ( 4 )   159 - 167   2014

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  • Role of the vasa vasorum and vascular resident stem cells in atherosclerosis

    Kawabe, J.-I. and Hasebe, N.

    BioMed Research International   2014   701571   2014

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1155/2014/701571

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  • Nerve growth factor stimulates regeneration of perivascular nerve, and induces the maturation of microvessels around the injured artery

    Asanome, A. and Kawabe, J.-I. and Matsuki, M. and Kabara, M. and Hira, Y. and Bochimoto, H. and Yamauchi, A. and Aonuma, T. and Takehara, N. and Watanabe, T. and Hasebe, N.

    Biochemical and Biophysical Research Communications   443 ( 1 )   150 - 155   2014

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2013.11.070

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  • Apurinic/apyrimidinic endonucelase 1 maintains adhesion of endothelial progenitor cells and reduces neointima formation

    Yamauchi, A. and Kawabe, J.-I. and Kabara, M. and Matsuki, M. and Asanome, A. and Aonuma, T. and Ohta, H. and Takehara, N. and Kitagawa, T. and Hasebe, N.

    American Journal of Physiology - Heart and Circulatory Physiology   305 ( 8 )   H1158 - H1167   2013

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1152/ajpheart.00965.2012

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  • Three cases of corticosteroid therapy triggering ventricular fibrillation in J-wave syndromes

    Sakamoto, N. and Sato, N. and Goto, M. and Kobayashi, M. and Takehara, N. and Takeuchi, T. and Talib, A.K. and Sugiyama, E. and Minoshima, A. and Tanabe, Y. and Akasaka, K. and Kawabe, J. and Kawamura, Y. and Doi, A. and Hasebe, N.

    Heart and Vessels   29 ( 6 )   867 - 872   2013

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00380-013-0443-x

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  • Prostacyclin stimulated integrin-dependent angiogenic effects of endothelial progenitor cells and mediated potent circulation recovery in ischemic Hind limb model

    Aburakawa, Y. and Kawabe, J.-I. and Okada, M. and Yamauchi, A. and Asanome, A. and Kabara, M. and Matsuki, M. and Takehara, N. and Nakagawa, N. and Okumura, S. and Minami, Y. and Mizukami, Y. and Yuhki, K.-I. and Ushikubi, F. and Hasebe, N.

    Circulation Journal   77 ( 4 )   1053 - 1062   2013

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1253/circj.CJ-12-0897

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  • The intrinsic prostaglandin E2-EP4 system of the renal tubular epithelium limits the development of tubulointerstitial fibrosis in mice Reviewed

    Nakagawa N, Yuhki K, Kawabe J, Fujino T, Takahata O, Kabara M, Abe K, Kojima F, Kashiwagi H, Hasebe N, Kikuchi K, Sugimoto Y, Narumiya S, Ushikubi F.

    Kidney Int   82 ( (2) )   158 - 171   2012.4

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  • The intrinsic prostaglandin E<inf>2</inf>-EP<inf>4</inf> system of the renal tubular epithelium limits the development of tubulointerstitial fibrosis in mice

    Nakagawa, N. and Yuhki, K.-I. and Kawabe, J.-I. and Fujino, T. and Takahata, O. and Kabara, M. and Abe, K. and Kojima, F. and Kashiwagi, H. and Hasebe, N. and Kikuchi, K. and Sugimoto, Y. and Narumiya, S. and Ushikubi, F.

    Kidney International   82 ( 2 )   158 - 171   2012

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/ki.2012.115

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  • A case of idiopathic systemic capillary leak syndrome with high serum levels of G-CSF on exacerbation. Reviewed

    Nakagawa N, Ota H, Tanabe Y, Kabara M, Matsuki M, Chinda J, Sakamoto N, Fujino T, Takehara N, Takeuchi T, Kawabe J, Sato N, Kawamura Y, Fukuhara T, Ikuta K, Kikuchi K, Hasebe N.

    Intern Med   50 ( 6 )   597 - 600   2011.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2169/internalmedicine.50.4857

  • Clinical and genetic investigation of a Japanese family with cardiac fabry disease. Identification of a novel α-galactosidase A missense mutation (G195V). Reviewed

    Nakagawa N, Maruyama H, Ishihara T, Seino U, Kawabe J, Takahashi F, Kobayashi M, Yamauchi A, Sasaki Y, Sakamoto N, Ota H, Tanabe Y, Takeuchi T, Takenaka T, Kikuchi K, Hasebe N.

    Int Heart J   52 ( 5 )   308 - 311   2011.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1536/ihj.52.308

  • Clinical and genetic investigation of a Japanese family with cardiac fabry disease: Identification of a novel α-galactosidase a missense mutation (G195V)

    Nakagawa, N. and Maruyama, H. and Ishihara, T. and Seino, U. and Kawabe, J. and Takahashi, F. and Kobayashi, M. and Yamauchi, A. and Sasaki, Y. and Sakamoto, N. and Ota, H. and Tanabe, Y. and Takeuchi, T. and Takenaka, T. and Kikuchi, K. and Hasebe, N.

    International Heart Journal   52 ( 5 )   308 - 311   2011

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  • A Case of Idiopathic Systemic Capillary Leak Syndrome with High Serum Levels of G-CSF on Exacerbation

    Nakagawa, N. and Ota, H. and Tanabe, Y. and Kabara, M. and Matsuki, M. and Chinda, J. and Sakamoto, N. and Fujino, T. and Takehara, N. and Takeuchi, T. and Kawabe, J.-I. and Sato, N. and Kawamura, Y. and Fukuhara, T. and Ikuta, K. and Kikuchi, K. and Hasebe, N.

    Internal Medicine   50 ( 6 )   597 - 600   2011

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  • Roles of prostanoids in the pathogenesis of cardiovascular diseases: Novel insights from knockout mouse studies

    Yuhki, K.-I. and Kojima, F. and Kashiwagi, H. and Kawabe, J.-I. and Fujino, T. and Narumiya, S. and Ushikubi, F.

    Pharmacology and Therapeutics   129 ( 2 )   195 - 205   2011

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.pharmthera.2010.09.004

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  • Hedgehog promotes neovascularization in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells. Reviewed

    Nakamura N, Sasaki J, Mizukami Y, Sugiyama Y, Yamazaki M, Fujii R, Kawamoto T, Koizumi K, Sato K, Fujiya M, Sasaki K, Tanno S, Okumura T, Shimizu N, Kawabe J, Karasaki H, Kono T, Ii M, Bardeesy N, Chung D C, Kohgo Y.

    ProsOne   5 ( (1) )   e8824 - e8835   2010.4

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    DOI: 10.1371/journal.pone.0008824

  • Prostaglandin I2 promotes recruitment of endothelial progenitor cells and limits vascular remodeling. Reviewed

    Kawabe J, Yuhki KI, Okada M, Kanno T, Yamauchi A, Tashiro N, Sasaki T, Okumura S, Nakagawa N, Aburakawa Y, Takehara N, Fujino T, Hasebe N, Narumiya S, Ushikubi F

    Atheroscler. Thromb Vasc Biol   30 ( (3) )   464 - 470   2010.4

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/ATVBAHA.109.193730

  • Transplanting normal vascular proangiogenic cells to tumor-bearing mice triggers vascular remodeling and reduces hypoxia in tumors

    Sasajima, J. and Mizukami, Y. and Sugiyama, Y. and Nakamura, K. and Kawamoto, T. and Koizumi, K. and Fujii, R. and Motomura, W. and Sato, K. and Suzuki, Y. and Tanno, S. and Fujiya, M. and Sasaki, K. and Shimizu, N. and Karasaki, H. and Kono, T. and Kawabe, J.-I. and Ii, M. and Yoshiara, H. and Kamiyama, N. and Ashida, T. and Bardeesy, N. and Chung, D.C. and Kohgo, Y.

    Cancer Research   70 ( 15 )   6283 - 6292   2010

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    DOI: 10.1158/0008-5472.CAN-10-0412

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  • Hedgehog promotes neovascularization in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells

    Nakamura, K. and Sasajima, J. and Mizukami, Y. and Sugiyama, Y. and Yamazaki, M. and Fujii, R. and Kawamoto, T. and Koizumi, K. and Sato, K. and Fujiya, M. and Sasaki, K. and Tanno, S. and Okumura, T. and Shimizu, N. and Kawabe, J.-I. and Karasaki, H. and Kono, T. and Ii, M. and Bardeesy, N. and Chung, D.C. and Kohgo, Y.

    PLoS ONE   5 ( 1 )   e8824   2010

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  • Prostaglandin I2 promotes recruitment of endothelial progenitor cells and limits vascular remodeling

    Kawabe, J.-I. and Yuhki, K.-I. and Okada, M. and Kanno, T. and Yamauchi, A. and Tashiro, N. and Sasaki, T. and Okumura, S. and Nakagawa, N. and Aburakawa, Y. and Takehara, N. and Fujino, T. and Hasebe, N. and Narumiya, S. and Ushikubi, F.

    Arteriosclerosis, Thrombosis, and Vascular Biology   30 ( 3 )   464 - 470   2010

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  • Roles of prostanoids in the pathogenesis of cardiovascular diseases

    Yuhki, K. and Kashiwagi, H. and Kojima, F. and Kawabe, J. and Ushikubi, F.

    International Angiology   29 ( 2 SUPPL. 1 )   19 - 27   2010

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  • Prostacyclin in vascular diseases - Recent insights and future perspectives

    Kawabe, J. and Ushikubi, F. and Hasebe, N.

    Circulation Journal   74 ( 5 )   836 - 843   2010

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    DOI: 10.1253/circj.CJ-10-0195

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  • Brugada syndrome case: Difficult differentiation between a concealed form and tricyclic antidepressant-induced Brugada sign

    Tashiro, N. and Sato, N. and Talib, A.K. and Talib, A.K. and Saito, E. and Okura, M. and Yamaki, M. and Nakagawa, N. and Sakamoto, N. and Ota, H. and Tanabe, Y. and Takeuchi, T. and Akasaka, K. and Kawabe, J. and Kawamura, Y. and Hasebe, N.

    Internal Medicine   48 ( 17 )   1535 - 1539   2009

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2169/internalmedicine.48.2370

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  • Administration of VEGF receptor tyrosine kinase inhibitor increases VEGF production causing angiogenesis in human small-cell lung cancer xenografts. Reviewed

    Sasaki T, Tanno S, Shibukawa K, Osanai S, Kawabe J, Ohsaki Y,

    Int J Oncol.   33 ( (3) )   525 - 532   2008.4

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    DOI: 10.3892/ijo_00000036

  • Administration of VEGF receptor tyrosine kinase inhibitor increases VEGF production causing angiogenesis in human small-cell lung cancer xenografts

    Sasaki, T. and Tanno, S. and Shibukawa, K. and Osanai, S. and Kawabe, J. and Ohsaki, Y.

    International Journal of Oncology   33 ( 3 )   525 - 532   2008

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  • Disruption of type 5 adenylyl cyclase enhances desensitization of cyclic adenosine monophosphate signal and increases Akt signal with chronic catecholamine stress. Reviewed

    Okumura S, Vatner DE, Kurotani R, Bai Y, Gao S, Yuan Z, Iwatsubo K, Ulucan C, Kawabe J, Ghosh K, Vatner SF, Ishikawa Y,

    Circulation   116   1776 - 1783   2007.4

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  • Disruption of type 5 adenylyl cyclase enhances desensitization of cyclic adenosine monophosphate signal and increases Akt signal with chronic catecholamine stress

    Okumura, S. and Vatner, D.E. and Kurotani, R. and Bai, Y. and Gao, S. and Yuan, Z. and Iwatsubo, K. and Ulucan, C. and Kawabe, J.-I. and Ghosh, K. and Vatner, S.F. and Ishikawa, Y.

    Circulation   116 ( 16 )   1776 - 1783   2007

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/CIRCULATIONAHA.107.698662

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  • Caveolin regulates microtubule polymerization in the vascular smooth muscle cells. Reviewed

    Kawabe J, Okumura S, Nathanson MA, Hasebe N, Ishikawa Y

    Biochem Biophys Res Com   342   164 - 169   2006.4

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2006.01.125

  • Role of prostanoids in inflammatory tachycardia: A reply to the letter of Dr. Eugene Nalivaiko [2]

    Yuhki, K.-I. and Kawabe, J.-I. and Ushikubi, F.

    American Journal of Physiology - Regulatory Integrative and Comparative Physiology   290 ( 6 )   2006

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    DOI: 10.1152/ajpregu.00019.2006

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  • Caveolin regulates microtubule polymerization in the vascular smooth muscle cells

    Kawabe, J.-I. and Okumura, S. and Nathanson, M.A. and Hasebe, N. and Ishikawa, Y.

    Biochemical and Biophysical Research Communications   342 ( 1 )   164 - 169   2006

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  • Fat, keeping the heart healthy?  Reviewed

    Yuhki K, Kawabe J , Ushikubi H

    Nat Med   1048 - 1049   2005.4

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  • Fat, keeping the heart healthy?

    Yuhki, K.-I. and Kawabe, J.-I. and Ushikubi, F.

    Nature Medicine   11 ( 10 )   1048 - 1049   2005

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/nm1005-1048

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  • Translocation of caveolin regulates stretch-induced ERK activity in vascular smooth muscle cells. Reviewed

    Kawabe J, Okumura S, Lee MC, Sadoshima J, and Ishikawa Y.

    Am J Physiol Heart Circ Physiol   286 ( (5) )   H1845 - H1852   2004.4

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1152/ajpheart.00593.2003

  • A cardiac sodium channel mutation identified in Brugada syndrome associated with atrial standstill. Reviewed

    Takehara N, Makita N, Kawabe J , Sato N, Kawamura Y, Kitabatake A, and Kikuchi K,

    J Intern Med   255   137 - 142   2004.4

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    DOI: 10.1046/j.0954-6820.2003.01247.x

  • Insulin resistance in skeletal muscles of caveolin-3-null mice. Reviewed

    Oshikawa J, Otsu K, Toya Y, Tsunematsu T, Hankins R, Kawabe J, Minamisawa S, Umemura S, Hagiwara Y, and Ishikawa Y.

    Proc Natl Acad Sci U S A   101 ( (34) )   12670 - 12675   2004.4

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  • Thermal treatment attenuates neointimal thickening with enhanced expression of heat-shock protein 72 and suppression of oxidative stress. Reviewed

    Okada M, Hasebe N, Aizawa Y, Izawa K, Kawabe J, and Kikuchi K

    Circulation   109 ( (14) )   1763 - 1768   2004.4

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    DOI: 10.1161/01.CIR.0000124226.88860.55

  • Insulin resistance in skeletal muscles of caveolin-3-null mice

    Oshikawa, J. and Otsu, K. and Toya, Y. and Tsunematsu, T. and Hankins, R. and Kawabe, J.-I. and Minamisawa, S. and Umemura, S. and Hagiwara, Y. and Ishikawa, Y.

    Proceedings of the National Academy of Sciences of the United States of America   101 ( 34 )   12670 - 12675   2004

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    DOI: 10.1073/pnas.0402053101

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  • A cardiac sodium channel mutation identified in Brugada syndrome associated with atrial standstill

    Takehara, N. and Makita, N. and Kawabe, J. and Sato, N. and Kawamura, Y. and Kitabatake, A. and Kikuchi, K.

    Journal of Internal Medicine   255 ( 1 )   137 - 142   2004

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  • Thermal Treatment Attenuates Neointimal Thickening with Enhanced Expression of Heat-Shock Protein 72 and Suppression of Oxidative Stress

    Okada, M. and Hasebe, N. and Aizawa, Y. and Izawa, K. and Kawabe, J.-I. and Kikuchi, K.

    Circulation   109 ( 14 )   1763 - 1768   2004

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  • Translocation of caveolin regulates stretch-induced ERK activity in vascular smooth muscle cells

    Kawabe, J.-I. and Okumura, S. and Lee, M.-C. and Sadoshima, J. and Ishikawa, Y.

    American Journal of Physiology - Heart and Circulatory Physiology   286 ( 5 55-5 )   H1845 - H1852   2004

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  • Effect of -adrenoceptor antagonist and ACE inhibitor on hypertension-associated changes in AC type V messenger RNA expression in SHR. Reviewed

    Fujino T, Hasebe N, Kawabe J , Fujita M, Fukuzawa J, Tobise K, and Kikuchi K.

    J Cardiovasc Pharmacol,   41   720 - 725   2003.4

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  • Type 5 AC disruption alters not only sympathetic but also parasympathetic and Ca-mediated cardiac regulation Reviewed

    Okumura S, Kawabe J et al)

    Circ Res   93   364 - 371   2003.4

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  • Nicotinic acetylcholine receptor alpha 7 regulates cAMP signal within lipid rafts Reviewed

    Oshikawa J, Toya Y, Fujita T, Egawa M, Kawabe J , Umemura S, and Ishikawa Y

    Am J Physiol Heart Circ Physiol   285   C567 - C574   2003.4

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  • Disruption of type 5 adenylyl cyclase gene preserves cardiac function against pressure overload. Reviewed

    Okumura S, Takagi G, Kawabe J , et al

    Proc Natl Acad Sci U S A,   100   9986 - 9990   2003.4

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  • Motor dysfunction in type 5 adenylyl cyclase-null mice.  Reviewed

    Iwamoto T, Okumura S, Iwatsubo K, Kawabe J , et al

    J Biol Chem,   278   6936 - 6940   2003.4

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  • Nicotinic acetylcholine receptor α<inf>7</inf> regulates cAMP signal within lipid rafts

    Oshikawa, J. and Toya, Y. and Fujita, T. and Egawa, M. and Kawabe, J. and Umemura, S. and Ishikawa, Y.

    American Journal of Physiology - Cell Physiology   285 ( 3 54-3 )   C567 - C574   2003

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  • Effect of β-adrenoceptor antagonist and angiotensin-converting enzyme inhibitor on hypertension-associated changes in adenylyl cyclase type V messenger RNA expression in spontaneously hypertensive rats

    Fujino, T. and Hasebe, N. and Kawabe, J.-I. and Fujita, M. and Fukuzawa, J. and Tobise, K. and Kikuchi, K.

    Journal of Cardiovascular Pharmacology   41 ( 5 )   720 - 725   2003

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    DOI: 10.1097/00005344-200305000-00008

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  • Motor dysfunction in type 5 adenylyl cyclase-null mice

    Iwamoto, T. and Okumura, S. and Iwatsubo, K. and Kawabe, J.-I. and Ohtsu, K. and Sakai, I. and Hashimoto, Y. and Izumitani, A. and Sango, K. and Ajiki, K. and Toya, Y. and Umemura, S. and Goshima, Y. and Arai, N. and Vatner, S.F. and Ishikawa, Y.

    Journal of Biological Chemistry   278 ( 19 )   16936 - 16940   2003

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    DOI: 10.1074/jbc.C300075200

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  • Disruption of type 5 adenylyl cyclase gene preserves cardiac function against pressure overload

    Okumura, S. and Takagi, G. and Kawabe, J.-I. and Yang, G. and Lee, M.-C. and Hong, C. and Liu, J. and Vatner, D.E. and Sadoshima, J. and Vatner, S.F. and Ishikawa, Y.

    Proceedings of the National Academy of Sciences of the United States of America   100 ( 17 )   9986 - 9990   2003

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    DOI: 10.1073/pnas.1733772100

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  • Type 5 adenylyl cyclase disruption alters not only sympathetic but also parasympathetic and calcium-mediated cardiac regulation

    Okumura, S. and Kawabe, J.-I. and Yatani, A. and Takagi, G. and Lee, M.-C. and Hong, C. and Liu, J. and Takagi, I. and Sadoshima, J. and Vatner, D.E. and Vatner, S.F. and Ishikawa, Y.

    Circulation Research   93 ( 4 )   364 - 371   2003

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    DOI: 10.1161/01.RES.0000086986.35568.63

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  • Mg reduces myocardial infarct size via enhancement of ade mechanism in rabbits. Reviewed

    Matsusaka T, Hasebe N, Jin YT, Kawabe J , and Kikuchi K

    Cardiovasc Res,   54   568 - 575   2002.4

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  • Down-regulation of NO accumulation by COX-2 induction and TXA2 production in interleukin-1b-stimulated rat aortic smooth muscle cells. Reviewed

    Shiokoshi T, Ohsaki Y, Kawabe J , Fujino T, and Kikuchi K.)

    J Hypertens,   20   455 - 461   2002.4

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  • Magnesium reduces myocardial infarct size via enhancement of adenosine mechanism in rabbits

    Matsusaka, T. and Hasebe, N. and Jin, Y.-T. and Kawabe, J. and Kikuchi, K.

    Cardiovascular Research   54 ( 3 )   568 - 575   2002

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    DOI: 10.1016/S0008-6363(02)00253-5

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  • Downregulation of nitric oxide accumulation by cyclooxygenase-2 induction and thromboxane A<inf>2</inf> production in interleukin-1β-stimulated rat aortic smooth muscle cells

    Shiokoshi, T. and Ohsaki, Y. and Kawabe, J. and Fujino, T. and Kikuchi, K.

    Journal of Hypertension   20 ( 3 )   455 - 461   2002

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    DOI: 10.1097/00004872-200203000-00021

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  • Pioglitazone enhances cytokine-induced apoptosis in vascular smooth muscle cells and reduces intimal hyperplasia. Reviewed

    Aizawa Y, Kawabe J , Hasebe N, Takehara N, and Kikuchi K.

    Circulation   104   455 - 460   2001.4

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    DOI: 10.1161/hc3001.092040

  • Changes in caveolin subtype protein expression in aging rat organs. Reviewed

    Kawabe J , Grant BS, Yamamoto M, Schwencke C, Okumura S, and Ishikawa Y.

    Mol Cell Endocrinol,   176   91 - 95   2001.4

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  • Pioglitazone enhances cytokine-induced apoptosis in vascular smooth muscle cells and reduces intimal hyperplasia

    Aizawa, Y. and Kawabe, J.-I. and Hasebe, N. and Takehara, N. and Kikuchi, K.

    Circulation   104 ( 4 )   455 - 460   2001

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  • Changes in caveolin subtype protein expression in aging rat organs

    Kawabe, J.-I. and Grant, B.S. and Yamamoto, M. and Schwencke, C. and Okumura, S. and Ishikawa, Y.

    Molecular and Cellular Endocrinology   176 ( 1-2 )   91 - 95   2001

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    DOI: 10.1016/S0303-7207(01)00472-5

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  • Glucose modifies the cross-talk between insulin and the beta-adrenergic ignaling system in vascular smooth muscle cells. Reviewed

    Kawabe J , Aizawa Y, Takehara N, Hasebe N, and Kikuchi K.

    J Hypertens,   18   1457 - 1464   2000.4

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  • High glucose attenuates insulin-induced MKP-1 expression in vascular smooth muscle cells.. Reviewed

    Takehara N, Kawabe J , Aizawa Y, Hasebe N, and Kikuchi K

    Biochim Biophys Acta   1497   244 - 252   2000.4

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  • High glucose attenuates insulin-induced mitogen-activated protein kinase phosphatase-1 (MKP-1) expression in vascular smooth muscle cells

    Takehara, N. and Kawabe, J.-I. and Aizawa, Y. and Hasebe, N. and Kikuchi, K.

    Biochimica et Biophysica Acta - Molecular Cell Research   1497 ( 2 )   244 - 252   2000

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    DOI: 10.1016/S0167-4889(00)00050-1

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  • Glucose modifies the cross-talk between insulin and the β-adrenergic signalling system in vascular smooth muscle cells

    Kawabe, J.-I. and Aizawa, Y. and Takehara, N. and Hasebe, N. and Kikuchi, K.

    Journal of Hypertension   18 ( 10 )   1457 - 1464   2000

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    DOI: 10.1097/00004872-200018100-00014

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  • Lovastatin prevents angiotensin II-induced cardiac hypertrophy in cultured neonatal rat heart cells. Reviewed

    Oi S, Haneda T, Osaki J, Kashiwagi Y, Nakamura Y, Kawabe J , and Kikuchi K

    Eur J Pharmacol,   376   139 - 148   1999.4

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    DOI: 10.1016/S0014-2999(99)00282-4

  • Lovastatin prevents angiotensin II-induced cardiac hypertrophy in cultured neonatal rat heart cells

    Oi, S. and Haneda, T. and Osaki, J. and Kashiwagi, Y. and Nakamura, Y. and Kawabe, J. and Kikuchi, K.

    European Journal of Pharmacology   376 ( 1-2 )   139 - 148   1999

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  • Enhanced expression of heparin-binding EGF-like growth factor and its receptor in hypertrophied left ventricle of SHR. Reviewed

    Fujino T, Hasebe N, Fujita M, Takeuchi K, Kawabe J , Tobise K, Higashiyama S, Taniguchi N, and Kikuchi K.

    Cardiovasc Res,   38   365 - 374   1998.4

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    DOI: 10.1016/S0008-6363(98)00010-8

  • Enhanced expression of heparin-binding EGF-like growth factor and its receptor in hypertrophied left ventricle of spontaneously hypertensive rats

    Fujino, T. and Hasebe, N. and Fujita, M. and Takeuchi, K. and Kawabe, J.-I. and Tobise, K. and Higashiyama, S. and Taniguchi, N. and Kikuchi, K.

    Cardiovascular Research   38 ( 2 )   365 - 374   1998

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  • Regulation of adenylyl cyclase isoforms by N-alkanols Reviewed

    Ebina T, Toya Y, Kawabe J, and Ishikawa Y.

    J Cell Biochem   66   450 - 456   1997.4

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  • Caveolin interaction with PKC. Isoenzyme-dependent regulation of kinase activity by the caveolin scaffolding domain peptide., Reviewed

    Oka N, Yamamoto M, Schwencke C, Kawabe J, Ebina T, Ohno S, Couet J, Lisanti MP, and Ishikawa Y.

    J Biol Chem   272   33416 - 33421   1997.4

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  • Isoform-dependent activation of adenylyl cyclase by proteolysis. Reviewed

    Ebina T, Toya Y, Oka N, Kawabe J, Schwencke C, and Ishikawa

    FEBS Lett,   401   223 - 226   1997.4

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  • Conformation-dependent activation of type II adenylyl cyclase by protein kinase C. Reviewed

    Ebina T, Kawabe J, Katada T, Ohno S, Homcy CJ, and Ishikawa Y

    J Cell Biochem   64   492 - 498   1997.4

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  • Isoform-specific regulation of adenylyl cyclase by oxidized catecholamines., Reviewed

    Ebina T, Toya Y, Oka N, Schwencke C, Kawabe J, and Ishikawa Y

    J Mol Cell Cardiol   29   1247 - 1254   1997.4

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  • Caveolin interaction with protein kinase C. Isoenzyme-dependent regulation of kinase activity by the caveolin scaffolding domain peptide

    Oka, N. and Yamamoto, M. and Schwencke, C. and Kawabe, J.-I. and Ebina, T. and Ohno, S. and Couet, J. and Lisanti, M.P. and Ishikawa, Y.

    Journal of Biological Chemistry   272 ( 52 )   33416 - 33421   1997

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    DOI: 10.1074/jbc.272.52.33416

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  • Erratum: Isoform-dependent activation of adenylyl cyclase by proteolysis (FEBS 18081) (FEBS Letters 401 (1997) (223-226) PII: S0014579396014755)

    Ebina, T. and Toya, Y. and Oka, N. and Kawabe, J.-I. and Schwencke, C. and Ishikawa, Y.

    FEBS Letters   411 ( 2-3 )   393 - 393   1997

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  • Isoform-specific regulation of adenylyl cyclase by oxidized catecholamines

    Ebina, T. and Toya, Y. and Oka, N. and Schwencke, C. and Kawabe, J.-I. and Ishikawa, Y.

    Journal of Molecular and Cellular Cardiology   29 ( 4 )   1247 - 1254   1997

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    DOI: 10.1006/jmcc.1996.0362

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  • Secretion of atrial natriuretic peptide from the left ventricle and heart in patients with hypertrophic cardiomyopathy: relationship with hemodynamic and echocardiographic profiles

    Ishii, Y. and Kawashima, E. and Kawabe, J. and Kikuchi, K.

    Journal of cardiology   30 ( 1 )   19 - 28   1997

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  • Isoform-dependent activation of adenylyl cyclase by proteolysis

    Ebina, T. and Toya, Y. and Oka, N. and Kawabe, J.-I. and Schwencke, C. and Ishikawa, Y.

    FEBS Letters   401 ( 2-3 )   223 - 226   1997

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    DOI: 10.1016/S0014-5793(96)01475-5

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  • Conformation-dependent activation of type II adenylyl cyclase by protein kinase C

    Ebina, T. and Kawabe, J.-I. and Katada, T. and Ohno, S. and Homcy, C.J. and Ishikawa, Y.

    Journal of Cellular Biochemistry   64 ( 3 )   492 - 498   1997

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    DOI: 10.1002/(SICI)1097-4644(19970301)64:3<492::AID-JCB15>3.0.CO;2-I

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  • Regulation of adenylyl cyclase isoforms by n-alkanols

    Ebina, T. and Toya, Y. and Kawabe, J.-I. and Ishikawa, Y.

    Journal of Cellular Biochemistry   66 ( 4 )   450 - 456   1997

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    DOI: 10.1002/(SICI)1097-4644(19970915)66:4<450::AID-JCB4>3.0.CO;2-K

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  • Soluble adenylyl cyclase from Spodoptera frugiperda (Sf9) cells. Purification and biochemical characterization. Reviewed

    Kawabe J,  Toya Y, Schwencke C, Oka N, Ebina T, and Ishikawa Y.

    J Biol Chem   271   20132 - 20137   1996.4

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  • Regulation of type V adenylyl cyclase by PMA-sensitive and –insensitive protein kinase C isoenzymes in intact cells. Reviewed

    Kawabe J, Ebina T, Toya Y, Oka N, Schwencke C, Duzic E, and Ishikawa Y.

    FEBS Lett,   384   273 - 276   1996.4

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  • Soluble adenylyl cyclase from Spodoptera frugiperda (Sf9) cells: Purification and biochemical characterization

    Kawabe, J.-I. and Toya, Y. and Schwencke, G. and Oka, N. and Ebina, T. and Ishikawa, Y.

    Journal of Biological Chemistry   271 ( 33 )   20132 - 20137   1996

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    DOI: 10.1074/jbc.271.33.20132

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  • Errata: Erratum to 'Multiplicity in type V adenylylcyclase: Type V-a and type V-b' (Molecular and Cellular Endocrinology 110 (1995) 45)

    Iwami, G. and Akanuma, M. and Kawabe, J. and Cannon, P.J. and Homcy, C.J. and Ishikawa, Y.

    Molecular and Cellular Endocrinology   122 ( 1 )   111 - 112   1996

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    DOI: 10.1016/0303-7207(96)03904-4

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  • Regulation of type V adenylyl cyclase by PMA-sensitive and -insensitive protein kinase C isoenzymes in intact cells

    Kawabe, J.-I. and Ebina, T. and Toya, Y. and Oka, N. and Schwencke, G. and Duzic, E. and Ishikawa, Y.

    FEBS Letters   384 ( 3 )   273 - 276   1996

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    DOI: 10.1016/0014-5793(96)00331-6

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  • Regulation of adenylyl cyclase by protein kinase A. Reviewed

    Iwami G, Kawabe J, Ebina T, Cannon PJ, Homcy CJ, and Ishikawa Y.

    J Biol Chem   270   12481 - 12484   1995.4

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  • Multiplicity in type V adenylylcyclase: type V-a and type V-b., Reviewed

    Iwami G, Akanuma M, Kawabe J, Cannon PJ, Homcy CJ, and Ishikawa Y.

    Mol Cell Endocrinol   110   43 - 47   1995.4

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  • Multiplicity in type V adenylylcyclase: type V-a and type V-b

    Iwami, G. and Akanuma, M. and Kawabe, J. and Cannon, P.J. and Homcy, C.J. and Ishikawa, Y.

    Molecular and Cellular Endocrinology   110 ( 1-2 )   43 - 47   1995

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    DOI: 10.1016/0303-7207(95)03514-8

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  • Regulation of adenylyl cyclase by protein kinase A

    Iwami, G. and Kawabe, J.-I. and Ebina, T. and Cannon, P.J. and Homcy, C.J. and Ishikawa, Y.

    Journal of Biological Chemistry   270 ( 21 )   12481 - 12484   1995

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    DOI: 10.1074/jbc.270.21.12481

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  • A novel peptide inhibitor of adenylyl cyclase (AC). A peptide from type V AC directly inhibits AC catalytic activity. Reviewed

    Kawabe J, Ebina T, Ismail S, Kitchen DB, Homcy CJ, and Ishikawa Y

    J Biol Chem   269   24906 - 24911   1994.4

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  • Differential activation of adenylyl cyclase by protein kinase C isoenzymes. Reviewed

    Kawabe J, Iwami G, Ebina T, Ohno S, Katada T, Ueda Y, Homcy CJ, and Ishikawa Y.

    J Biol Chem   269   6554 - 6558   1994.4

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  • Differential activation of adenylyl cyclase by protein kinase C isoenzymes

    Kawabe, J.-I. and Iwami, G. and Ebina, T. and Ohno, S. and Katada, T. and Ueda, Y. and Homcy, C.J. and Ishikawa, Y.

    Journal of Biological Chemistry   269 ( 24 )   16554 - 16558   1994

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  • Erratum: Differential activation of adenylyl cyclase by protein kinase C isoenzymes (Journal of Biological Chemistry (1994) 269 (16554-16558))

    Kawabe, J.-I. and Iwami, G. and Ebina, T. and Ohno, S. and Katada, T. and Ueda, Y. and Homcy, C.J. and Ishikawa, Y.

    Journal of Biological Chemistry   269 ( 36 )   22912 - 22912   1994

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  • A novel peptide inhibitor of adenylyl cyclase (AC). A peptide from type V AC directly inhibits AC catalytic activity

    Kawabe, J.-I. and Ebina, T. and Ismail, S. and Kitchen, D.B. and Homey, C.J. and Ishikawa, Y.

    Journal of Biological Chemistry   269 ( 40 )   24906 - 24911   1994

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  • In vivo generation of an adenylylcyclase isoform with a half-molecule motif. Reviewed

    Katsushika S, Kawabe J, Homcy CJ, and Ishikawa Y.

    J Biol Chem   268   2273 - 2276   1993.4

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  • Adenylylcyclase: characterization in the heart and its regulation in heart failure. Reviewed

    Homcy CJ, Katsushika S, Kawabe J. et al

    Hypertens Res   16   79 - 83   1993.4

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  • In vivo generation of an adenylylcyclase isoform with a half-molecule motif

    Katsushika, S. and Kawabe, J.-I. and Homcy, C.J. and Ishikawa, Y.

    Journal of Biological Chemistry   268 ( 4 )   2273 - 2276   1993

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  • Adenylylcyclase: Characterization in the Heart and Its Regulation in Heart Failure

    Homcy, C.J. and Ishikawa, Y. and Katsushika, S. and Kawabe, J.-I. and Ishikawa, Y. and Kiuchi, K. and Komamura, K. and Vatner, D.E. and Vatner, S.F.

    Hypertension Research   16 ( 2 )   79 - 83   1993

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    DOI: 10.1291/hypres.16.79

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  • Role of endothelium in biphasic hypoxic response of the isolated poumonary artery in the rat

    Ogawa, Y. and Kawabe, J.-I. and Onodera, S. and Tobise, K. and Morita, K. and Harada, T. and Hirayama, T. and Takeda, A.

    JAPANESE CIRCULATION JOURNAL   57 ( 3 )   228 - 236   1993

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    DOI: 10.1253/jcj.57.228

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  • Isolation and characterization of a novel cardiac adenylylcyclase cDNA. Reviewed

    Ishikawa Y, Katsushika S, Chen L, Halnon NJ, Kawabe J , and Homcy CJ.

    J Biol Chem   267   13553 - 13557   1992.4

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  • Down-regulation of PKC potentiates ANP-stimulated cGMP accumulation in vascular smooth-muscle cells., Reviewed

    Kawabe J, Ohsaki Y, and Onodera S.

    Biochim Biophys Acta   1175   81 - 87   1992.4

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  • Cloning and characterization of a sixth AC isoform: types V and VI constitute a subgroup within the mammalian AC family  Reviewed

    Katsushika S, Chen L, Kawabe J , Nilakantan R, Halnon NJ, Homcy CJ, and Ishikawa Y.

    Proc Natl Acad Sci U S A   89   8774 - 8778   1992.4

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  • Down-regulation of protein kinase C potentiates atrial natriuretic peptide-stimulated cGMP accumulation in vascular smooth-muscle cells

    Kawabe, J.-i. and Ohsaki, Y. and Onodera, S.

    BBA - Molecular Cell Research   1175 ( 1 )   81 - 87   1992

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    DOI: 10.1016/0167-4889(92)90012-Z

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  • Role of endothelium in hypoxia-induced contraction of isolated rat pulmonary artery

    Ogawa, Y. and Kawabe, J. and Morita, K. and Harada, T. and Hirayama, T. and Takeda, A. and Tobise, K. and Onodera, S.

    Japanese Journal of Pharmacology   58 ( SUPPL. 2 )   1992

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  • Cloning and characterization of a sixth adenylyl cyclase isoform: Types V and VI constitute a subgroup within the mammalian adenylyl cyclase family

    Katsushika, S. and Chen, L. and Kawabe, J.-I. and Nilakantan, R. and Halnon, N.J. and Homcy, C.J. and Ishikawa, Y.

    Proceedings of the National Academy of Sciences of the United States of America   89 ( 18 )   8774 - 8778   1992

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1073/pnas.89.18.8774

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  • Isolation and characterization of a novel cardiac adenylylcyclase cDNA

    Ishikawa, Y. and Katsushika, S. and Chen, L. and Halnon, N.J. and Kawabe, J.-I. and Homcy, C.J.

    Journal of Biological Chemistry   267 ( 19 )   13553 - 13557   1992

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  • The Combination Effect of Caffeine and Cisplatin on a Human Lung Cancer Cell Line

    Yoshinobu, O, I. and Toshiaki, F. and Jun-ichi, K. and Hiroyuki, M. and Sokichi, O.

    Japanese Journal of Lung Cancer   30 ( 3 )   341 - 349   1990

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    DOI: 10.2482/haigan.30.341

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  • Effects of chronic volume loading on atrial natriuretic peptide release in human

    Kawabe, J. and Ohsaki, Y. and Onodera, S. and Inoue, H. and Hirayama, T. and Akiba, Y. and Osanai, S. and Sakai, H. and Ishida, S. and Nakano, H.

    Kokyu to junkan. Respiration &amp; circulation   38 ( 11 )   1121 - 1125   1990

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  • Cefdinir in respiratory tract infection

    Matsumoto, H. and Akiba, Y. and Osanai, S. and Ishida, S. and Kawabe, J. and Osaki, Y. and Fujikane, T. and Sasakli, N. and Onodera, S. and Nakano, H.

    CHEMOTHERAPY   37   257 - 262   1989

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.11250/chemotherapy1953.37.Supplement2_257

    Scopus

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Books

  • Biology of Pericytes - Recent Advances

    Jun-ichi Kawabe( Role: Joint author)

    Springer Nature  2021 

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    Language:English   Book type:Scholarly book

  • 本態性高血圧の成因としての血管内皮の役割 新しい診断と治療のABC 循環器3 高血圧 改訂第二版

    川辺淳一( Role: Sole author)

    最新医学社  2009.4 

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    Language:Japanese   Book type:Scholarly book

  • カルシウム拮抗薬の特徴と使用法  診断と治療

    川辺淳一、長谷部直幸、菊池健次郎( Role: Joint author)

    診断と治療社  2006.4 

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    Language:Japanese   Book type:Scholarly book

  • 降圧薬と臓器保護作用 高血圧 Up to Date 医学のあゆみ

    川辺淳一、長谷部直幸、菊池健次郎( Role: Joint author)

    医歯薬出版  2005.4 

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    Language:Japanese   Book type:Scholarly book

  • 循環器科 特集 高血圧 up to date 循環器内科

    川辺淳一、長谷部直幸、菊池健次郎( Role: Joint author)

    科学評論社  2004.4 

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    Language:Japanese   Book type:Scholarly book

  • 最新の治療ストラテジー ベーターブロッカーの使い方 臨床雑誌内科

    竹原有史、川辺淳一、長谷部直幸、菊池健次郎( Role: Joint author)

    南江堂  2000.4 

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    Language:Japanese   Book type:Scholarly book

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MISC

  • Role of EphA7+ multipotent pericytes in tissue regeneration and its clinical application

    Kohei Kano, Jun-ichi Kawabe

    37 ( 12 )   31 - 38   2020.12

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

  • Prostacyclin in Vascular Disease; Recent Insights and Future Perspectives

    Kawabe J. Ushikubi F, Hasebe N

    Circ Res   74 ( (5) )   836 - 843   2010.4

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    Authorship:Lead author   Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Roles of Prostanoids in the Pathogenesis of Cardiovascular Diseases

    Yuhki K, Kashiwagi H, Kojima F, Kawabe J and Ushikubi F

    International Angiology   29   19 - 27   2010.4

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • プロスタサイクリンによる血管内皮前駆細胞機能調節と血管保護への影響

    川辺淳一

    血栓と循環   17 ( (4) )   86 - 87   2009.4

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    Authorship:Lead author   Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 心血管系におけるプロスタノイドの役割    

    結城幸一、藤野貴行、高山浩二、川辺淳一、牛首文隆

    生体の科学   57 ( (6) )   598 - 601   2006.4

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • カルシウム拮抗薬の特徴と使用法   

    川辺淳一、長谷部直幸、菊池健次郎

    診断と治療   94 ( (3) )   391 - 395   2006.4

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    Authorship:Lead author   Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 温熱による新生内膜脂厚の抑制効果-熱ショック蛋白の発現と酸化ストレスの抑制と役割- 

    岡田 基、長谷部直幸、会澤佳昭、井澤和眞、川辺淳一、菊池健次郎

    血 圧   11   263 - 266   2004.4

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • JNC7の長所と短所                        

    川辺淳一、長谷部直幸、菊池健次郎

    循環器内科   56 ( (5) )   507 - 511   2004.4

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    Authorship:Lead author   Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

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Presentations

  • 多細胞生物の臓器再生における毛細血管幹細胞の役割

    川辺淳一

    日本心脈管作動物質学会 

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    Event date: 2021.7

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  • Role of multipotent perivascular cells in peripheral nerve regeneration

    川辺淳一

    日本循環器学会 

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    Event date: 2021.3

    Language:English   Presentation type:Oral presentation (invited, special)  

  • Peripheral Nerve is Critical for Vasa Vasorum Maturation in Injured Vascular Walls. - Effects of SubstanceP on ricytesmediated Vascular Maturation-

    Akira Asanome, Junichi Kawabe, Maki Kabara, Motoki Matsuki, Atsushi Yamauchi, Naoki Nakagawa, Hisanobu Ohta, Naofumi akehara, Naoyuki Hasebe

    Peripheral Nerve is Critical for Vasa Vasorum Maturation in Injured Vascular Walls. - Effects of SubstanceP on ericytesmediated Vascular Maturation- 

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    Event date: 2012.11

    Language:English   Presentation type:Oral presentation (general)  

    Venue:福岡、日本  

  • Apurinic/apyrimidinic Endonuclease (Ape1) in Endotherial Progenitor Cells (EPCs) has an important role in healing injured ascular wall through adhesion on the sites with much oxidative stress   International conference

    Atsushi Yamauchi, Jun-ichi Kawabe, Maki Kabara, Akira Asanome,Motoki Matsuki, Naoki Nakagawa, Naofumi Takehara, Naoyuki Hasebe

    国際血管生物学会 

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    Event date: 2012.6

    Language:English   Presentation type:Poster presentation  

    Venue:ビースバーデン、ドイツ  

  • Peripheral Nerve is Critical for Vasa Vasorum Maturation in Injured Vascular Walls. -Effects of Substance P on Pericytes-ediated Vascular Maturation International conference

    Akira Asanome, Jun-ichi Kawabe, Maki Kabara, Motoki Matsuki, Atsushi Yamauchi, Naoki Nakagawa, Hisanobu Ota, Naofumi Takehara, Hiroki Bochimoto, Yoshiki Hira, Naoyuki Hasebe

    AHA (アメリカ心臓病学会) 

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    Event date: 2011.11

    Language:English   Presentation type:Oral presentation (general)  

    Venue:オーランド、米国  

  • Nerve Growth Factor Induces Maturation of Vasa Vasorum Neovasculature in Injured Vascular walls

    Akira Asanome, Junichi Kawabe, Motoki Matsuki, Atsushi Yamauchi, Naofumi Takehara, Motoi Okada, Naoyuki Hasebe

    日本循環器学会 

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    Event date: 2011.8

    Language:English   Presentation type:Oral presentation (general)  

    Venue:横浜、日本  

  • Enhanced Inhibition of Neointimal Hyperplasia by Overexpression of Apurinic/apyrimidinic Endonuclease (APE1) in Endothelial Progenitor Cells International conference

    Atsushi Yamauchi, Jun-ichi Kawabe, Maki Kabara, Akira Asanome,Motoki Matsuki, Naoki Nakagawa, Naofumi Takehara, Naoyuki Hasebe

    日本血管生物学会 

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    Event date: 2010.12 - 2012.12

    Language:English   Presentation type:Poster presentation  

    Venue:大阪、日本  

  • Peripheral Nerve is critical for Vasa Vasorum Maturation in Injured Vascular Walls. -Effects of SubstanceP on Pericytes-

    Akira Asanome, Junichi Kawabe, Maki Kabara, Motoki Matsuki, Atsushi Yamauchi, Naoki Nakagawa, Hisanobu Ohta, Naofumi akehara, Naoyuki Hasebe

    日本血管生物学会 

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    Event date: 2010.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:大阪、日本  

  • 内皮前駆細胞(EPC)を介したプロスタサイクリンの下肢虚血改善作用 -血管周細胞分化による血管新生効果-

    浅野目 晃、川辺 淳一、山内 敦司、竹原 有史、長谷部 直幸

    日本脈管学会 総会 

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    Event date: 2010.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:旭川  

  • The cardioprotective effect of prostaglandin E2/EP4 system is important for the late phase preconditioning International conference

    T Kanno, J Kawabe, Yuhki, N Takehara, F Ushikubi, N Hasebe

    AHA (アメリカ心臓病学会) 

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    Event date: 2009.11

    Language:English   Presentation type:Oral presentation (general)  

    Venue:(Orland, USA)  

  • Prostacylcin augments endotherial progenitor cell functions and rescue peripheral ischemia

    M Okada, J Kawabe, Y Aburakawa, T Kanno, A Yamauchi, N Nakagawa, N Tashiro, MYamaki, F Ushikubi and N Hasebe

    日本循環器学会 

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    Event date: 2009.3

    Language:English   Presentation type:Oral presentation (general)  

    Venue:(大阪、日本)  

  • Prostacyclin System in Endothelial Progenitor Cells is crucial for Regulation of Vascular Remodeling through their recruitment to injured vascular walls.

    Yamauchi A, Kawabe J, Kobayashi M, Kannno T, Ushikubi F, Hasebe N, P

    日本循環器学会 

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    Event date: 2009.3

    Language:English   Presentation type:Oral presentation (general)  

    Venue:(大阪、日本)  

  • Prostacyclin relieves peripheral ischemia through enhancement of critical functions of endothelial progenitor cells International conference

    M Okada, J Kawabe, Y Aburakawa, T Kanno, A Yamauchi, N Nakagawa, N Tashiro, MYamaki, F Ushikubi and N Hasebe

    AHA (アメリカ心臓病学会) 

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    Event date: 2008.11

    Language:English   Presentation type:Oral presentation (general)  

    Venue:(New Orleans, USA)  

  • Impaired functional endothelial progenitor cells inhibited growth of Prostacycline signaling as a target for cancer therapy -. International conference

    Sasaki T, Okumura S, Shibukawa K, Osanai S, Kawabe J, Ohsaki Y

    AACR(アメリカ癌研究学会)  

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    Event date: 2008.4

    Language:English   Presentation type:Oral presentation (general)  

    Venue:(San Diego, USA)  

  • Role of Autocrine Prostacyclin System in Crucial Functions of Endothelial Progenitor Cells.

    Kawabe J, Kanno T, Tashiro N, Okada M, Yuhki K, Ushikubi F, Hasebe N

    日本循環器学会 

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    Event date: 2008.3

    Language:English   Presentation type:Oral presentation (general)  

    Venue:(福岡、日本)  

  • Decreased Susceptibility to Release of TGF-β1 from Platelet and Microalbuminuria inTXA2 Receptor Deficient Mice with Diabetes Mellitus

    Fujino T, Suzuki Y, Kawabe J, Yuhki K, Fukuzawa J, Matsuki M, Nakagawa, N Hasebe N, Ushikubi F

    日本循環器学会 

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    Event date: 2008.3

    Language:English   Presentation type:Oral presentation (general)  

    Venue:(福岡、日本)   

  • Deletion of prostacyclin-receptor in bone marrow attenuates differentiation of endothelial progenitor cells, and Enhances Vascular Intimal Hyperplasia Circulation. International conference

    Kawabe J, Yuhki K, Kannno T, Hasebe N, Ushikubi F

    AHA (アメリカ心臓病学会) 

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    Event date: 2007.11

    Language:English   Presentation type:Oral presentation (general)  

    Venue:(Orland, USA)  

  • Decreased susceptibility to endothelial dysfunction and glomerular remodeling in diabetes mellitus in thromboxane A2 receptor deficient mice.

    Fujino T, Suzuki Y, Kawabe J, Nakagawa N, Yuhki K, Hasebe N, Kikuchi K, Ushikubi F

    日本高血圧学会 

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    Event date: 2007.10

    Language:English   Presentation type:Oral presentation (general)  

    Venue:(沖縄、日本)  

  • 内皮前駆細胞分化とプロスタノイド-再生医療への応用にむけて- 

    川辺淳一

    第2回 名寄・士別循環器研究会  

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    Event date: 2007.4

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:士別(日本)  

  • Decreased Susceptibility to Glomerular Regeneration in Thromboxane A2 Receptor Deficient Mice 

    Fujino T, Abe K, Nakagawa N, Yuhki K, Kawabe J, Hasebe N, Kikuchi K, Ukikubi F

    日本循環器学会 

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    Event date: 2007.3

    Language:English   Presentation type:Oral presentation (general)  

    Venue:(神戸、日本)  

  • Deletion of PGI2-receptor (IP) in Bone Marrow Enhances Progenitor Cells-Mediated Vascular Intimal Hyperplasia

    Kawabe J, Kanno T, Yuhki K, Hasebe N, Kikuchi K, Usikubi F

    日本循環器学会 

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    Event date: 2007.3

    Language:English   Presentation type:Oral presentation (general)  

    Venue:(神戸、日本)  

  • Decreased Susceptibility to Glomerular Hypertrophy and Albuminuria in Thromboxane A2 Receptor Deficient Mice.

    Fujino T, Abe K, Nakagawa N, Yuhki K, Kawabe J, et al

    ISHR (国際高血圧学会) 

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    Event date: 2006.10

    Language:English   Presentation type:Oral presentation (general)  

    Venue:(福岡、日本)  

  • Thermal treatment attenuates vascular atherosclerosis and lowers blood pressure in spontaneously hypertensive rats. International conference

    Tashiro N, Okada M, Izawa K, Aizawa Y, Kawabe J, et al

    ISHR (国際高血圧学会) 

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    Event date: 2006.10

    Language:English   Presentation type:Oral presentation (general)  

    Venue:(福岡、日本)  

  • Combination of Pitavastatin and Thermal Treatment Attenuates Cytokine-induced Monocye/macrophage Activation and Oxidative Stress. International conference

    Okada M, Hasebe N, Tashiro N, Yamauchi A, Kawabe J Kikuchi K

    ISHR (国際高血圧学会) 

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    Event date: 2006.10

    Language:English   Presentation type:Oral presentation (general)  

    Venue:(福岡、日本)  

  • Repeated Thermal Treatment Reduces Adventitial Inflammatory Response in Arteriosclerosis. International conference

    Okada M, Hasebe N, Tashiro N, Yamauchi A, Kawabe J Kikuchi K

    ISHR (国際高血圧学会) 

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    Event date: 2006.10

    Language:English   Presentation type:Oral presentation (general)  

    Venue:(福岡、日本)  

  • 炎症性頻脈の発生機序:プロスタノイドによる心機能調節 

    川辺淳一

    第2回 宮崎サイエンスキャンプ    

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    Event date: 2006.4

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:宮崎(日本)  

  • 血管新生内膜形成におけるプロスタノイドの役割

    川辺淳一

    第8回 旭川血管リモデリング研究会  

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    Event date: 2006.4

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:旭川(日本)  

  • PE-520/ Combination of pitavastatin and therminal treatment attenuates angiotensin Ⅱ-induced cellular activation and oxidative stress.

    Okada M, Tashiro N, Izawa K, Kawabe J, Hasebe N, Kikuchi K

    日本循環器学会 

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    Event date: 2006.3

    Language:English   Presentation type:Oral presentation (general)  

    Venue:(名古屋、日本)  

  • 炎症性頻脈の発生機序

    川辺淳一

    第7回 旭川血管リモデリング研究会  

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    Event date: 2005.4

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:旭川(日本)  

  • 心血管系におけるプロスタノイドの役割

    川辺淳一

    第23回 病態生理研究会  

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    Event date: 2005.4

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:札幌(日本)  

  • Paradoxical suppression of angiotensin II-induced vascular remodeling in impaired glutathione redox system.

    Izawa K, Hasebe N, Okada M, Sumitomo K, Kawabe J, et al

    日本循環器学会 

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    Event date: 2005.3

    Language:English   Presentation type:Oral presentation (general)  

    Venue:(横浜、日本)  

  • Impaired glutathione redox regulation paradoxically suppresses angiotensin Ⅱ-induced vascular remodeling International conference

    Izawa K, Hasebe N, Okada M, Kawabe J, et al

    AHA(アメリカ心臓病学会 

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    Event date: 2004.11

    Language:English   Presentation type:Oral presentation (general)  

    Venue:(New Orleans, USA)  

  • β-adrenergic and muscarinic regulation of the heart requires type 5 adenylyl cyclase.

    Okumura S, Kawabe J, et al 

    日本循環器学会 

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    Event date: 2004.3

    Language:English   Presentation type:Oral presentation (general)  

    Venue:(東京、日本)  

  • The type 5 adenylyl cyclase mediates Ca2+-mediated regulation of Ca2+ channels in the heart.

    Kawabe J, Ishikawa Y, et al 

    日本循環器学会 

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    Event date: 2004.3

    Language:English   Presentation type:Oral presentation (general)  

    Venue:(東京、日本)  

  • Disruption of the type 5 adenylyl cyclase gene preserve cardiac function against pressure overload.

    Okumura S, Kawabe J, et al

    日本循環器学会 

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    Event date: 2004.3

    Language:English   Presentation type:Oral presentation (general)  

    Venue:(東京、日本)  

  • Caveolin modulates microtubule polymerization in vascular smooth muscle cells.

    Kawabe J, Ishikawa Y, et al

    日本循環器学会 

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    Event date: 2004.3

    Language:English   Presentation type:Oral presentation (general)  

    Venue:(東京、日本)  

  • Translocation of caveolin regulates stretch- induced ERK activity in vascular smooth muscle cells.  

    Kawabe J, Ishikawa Y, et al

    日本循環器学会 

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    Event date: 2004.3

    Language:English   Presentation type:Oral presentation (general)  

    Venue:(東京、日本)  

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Research Projects

  • 組織幹細胞維持機構解明のための微小血管システムの構築

    2018.4

    基盤研究(B)

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    組織幹細胞維持機構解明のための微小血管システムの構築

  • 毛細血管幹細胞の組織内維持システムの証明

    2017.7 - 2020.3

    萌芽研究

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    毛細血管幹細胞の組織内維持システムの証明

  • 新規因子による血管成熟機構の解明と、動脈硬化に対する治療法の開発

    2017.4 - 2020.3

    基盤研究(B)

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    新規因子Ninjurin1による血管成熟機構の解明と、動脈硬化に対する治療法の開発

  • 毛細血管幹細胞(CapSCs)の再生医療における新規細胞ソースとしての開発

    2016.4

    第一三共株式会社 三菱UFJキャピタル 

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    毛細血管幹細胞(CapSCs)の再生医療における新規細胞ソースとしての開発

  • 人工血管を利用した血管新生制御機構の解析

    2016.4

    東京大学  

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    人工血管システムを構築して、血管形成に関わる因子の探索および解析

  • 再生医療開発にむけた間葉系幹細胞様の毛細血管周細胞の機能解明

    2013.4 - 2016.3

    基盤研究(C)

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    再生医療開発にむけた間葉系幹細胞様の毛細血管周細胞の機能解明

  • DNA修復機構APE-1の心筋幹細胞に対する細胞機能再生及び虚血耐性に対する効果

    2011.4 - 2014.3

    基盤研究(C)

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    DNA修復機構APE-1の心筋幹細胞に対する細胞機能再生及び虚血耐性に対する効果

  • 障害血管リモデリングおよび血管外膜微小血管新生における神経再生因子の役割

    2010.4 - 2013.3

    基盤研究(C)

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    障害血管リモデリングおよび血管外膜微小血管新生における神経再生因子の役割

  • 骨髄由来内皮前駆細胞におけるプロスタノイドの包括的役割解明

    2010.4 - 2013.3

    基盤研究(C)

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    骨髄由来内皮前駆細胞におけるプロスタノイドの包括的役割解明

  • 骨髄由来血管内皮前駆細胞の制御によるがん治療の検討

    2008.4 - 2011.3

    基盤研究(C)

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    骨髄由来血管内皮前駆細胞の制御によるがん治療の検討

  • プロスタノイドの血管病変形成における役割-骨髄細胞分化に及ぼす影響-

    2006.4 - 2009.3

    基盤研究(C)

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    プロスタノイドの血管病変形成における役割-骨髄細胞分化に及ぼす影響-

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Other

  • 講座間の横断的研究連携活動 1.旭川医科大学 脈管研究クラスター 代表幹事 学内臨床、基礎6講座による研究会 定期学術セミナー開催

  • 講座間の横断的研究連携活動 2.北海道カルディアックセミナー 幹事 道内3医学部循環器内科講座による 連携研究会

Social Activities

  • 平成24年度 医科学研究セミナー 

    2012.6

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    毛細血管から見えてくる難治性疾患の病態理解と治療開発

  • 平成24年度 旭川医大39派遣講座 知っておきたい旭川医大 

    2011.6

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    からだの”母なる海”毛細血管のはなし -老いも病気も毛細血

  • 平成21年度 旭川医科大学後期公開講座 失った臓器はどこまで蘇るの? 再生医学の最新情報 よみがえる血管 心血管病の新しい治療法 ―血管再生医療の今と未来― (旭川)

    2009.10

  • 動脈硬化の最新のトピックス  南宗谷地域医療懇話会 中頓別(日本)

    2008.2