Pericyte-specific ninjurin1 deletion attenuates vessel maturation and blood flow recovery in hind limb ischemia

Minoshima, A. and Kabara, M. and Matsuki, M. and Yoshida, Y. and Kano, K. and Tomita, Y. and Hayasaka, T. and Horiuchi, K. and Saito, Y. and Aonuma, T. and Nishimura, M. and Maruyama, K. and Nakagawa, N. and Sawada, J. and Takehara, N. and Hasebe, N. and Kawabe, J.-I.

Arteriosclerosis, Thrombosis, and Vascular Biology   38 ( 10 )   2358 - 2370   2018年

A 3D in vitro pericyte-supported microvessel model: Visualisation and quantitative characterisation of multistep angiogenesis

Lee, E. and Takahashi, H. and Pauty, J. and Kobayashi, M. and Kato, K. and Kabara, M. and Kawabe, J.-I. and Matsunaga, Y.T.

Journal of Materials Chemistry B   6 ( 7 )   1085 - 1094   2018年

Apoptosis-resistant cardiac progenitor cells modified with apurinic/apyrimidinic endonuclease/ redox factor 1 gene overexpression regulate cardiac repair after myocardial infarction

Aonuma, T. and Takehara, N. and Maruyama, K. and Kabara, M. and Matsuki, M. and Yamauchi, A. and Kawabe, J.-I. and Hasebe, N.

Stem Cells Translational Medicine   5 ( 8 )   1067 - 1078   2016年

Prostaglandin I2 analog suppresses lung metastasis by recruiting pericytes in tumor angiogenesis

Minami, Y. and Sasaki, T. and Bochimoto, H. and Kawabe, J.-I. and Endo, S. and Hira, Y. and Watanabe, T. and Okumura, S. and Hasebe, N. and Ohsaki, Y.

International Journal of Oncology   46 ( 2 )   548 - 554   2015年

Association between microalbuminuria predicting in-stent restenosis after myocardial infarction and cellular senescence of endothelial progenitor cells

Ota, H. and Takehara, N. and Aonuma, T. and Kabara, M. and Matsuki, M. and Yamauchi, A. and Takeuchi, T. and Kawabe, J.-I. and Hasebe, N.

PLoS ONE   10 ( 4 )   e0123733   2015年

Ninjurin1 is a novel factor to regulate angiogenesis through the function of pericytes

Matsuki, M. and Kabara, M. and Saito, Y. and Shimamura, K. and Minoshima, A. and Nishimura, M. and Aonuma, T. and Takehara, N. and Hasebe, N. and Kawabe, J.-I.

Circulation Journal   79 ( 6 )   1363 - 1371   2015年

Immortalized multipotent pericytes derived from the vasa vasorum in the injured vasculature. A cellular tool for studies of vascular remodeling and regeneration

Kabara, M. and Kawabe, J.-I. and Matsuki, M. and Hira, Y. and Minoshima, A. and Shimamura, K. and Yamauchi, A. and Aonuma, T. and Nishimura, M. and Saito, Y. and Takehara, N. and Hasebe, N.

Laboratory Investigation   94 ( 12 )   1340 - 1354   2014年

Initial reduction of oxidative stress by angiotensin receptor blocker contributes long term outcomes after percutaneous coronary intervention

Noro, T. and Takehara, N. and Sumitomo, K. and Takeuchi, T. and Ishii, Y. and Kato, J.-I. and Kawabe, J.-I. and Hasebe, N.

American Journal of Cardiovascular Disease   4 ( 4 )   159 - 167   2014年

Role of the vasa vasorum and vascular resident stem cells in atherosclerosis

Kawabe, J.-I. and Hasebe, N.

BioMed Research International   2014   701571   2014年

Nerve growth factor stimulates regeneration of perivascular nerve, and induces the maturation of microvessels around the injured artery

Asanome, A. and Kawabe, J.-I. and Matsuki, M. and Kabara, M. and Hira, Y. and Bochimoto, H. and Yamauchi, A. and Aonuma, T. and Takehara, N. and Watanabe, T. and Hasebe, N.

Biochemical and Biophysical Research Communications   443 ( 1 )   150 - 155   2014年

Impaired glutathione redox system paradoxically suppresses angiotensin II-induced vascular remodeling

Izawa, K. and Okada, M. and Sumitomo, K. and Nakagawa, N. and Aizawa, Y. and Kawabe, J. and Kikuchi, K. and Hasebe, N.

PLoS ONE   9 ( 10 )   e108115   2014年

Three cases of corticosteroid therapy triggering ventricular fibrillation in J-wave syndromes

Sakamoto, N. and Sato, N. and Goto, M. and Kobayashi, M. and Takehara, N. and Takeuchi, T. and Talib, A.K. and Sugiyama, E. and Minoshima, A. and Tanabe, Y. and Akasaka, K. and Kawabe, J. and Kawamura, Y. and Doi, A. and Hasebe, N.

Heart and Vessels   29 ( 6 )   867 - 872   2013年

Prostacyclin stimulated integrin-dependent angiogenic effects of endothelial progenitor cells and mediated potent circulation recovery in ischemic Hind limb model

Aburakawa, Y. and Kawabe, J.-I. and Okada, M. and Yamauchi, A. and Asanome, A. and Kabara, M. and Matsuki, M. and Takehara, N. and Nakagawa, N. and Okumura, S. and Minami, Y. and Mizukami, Y. and Yuhki, K.-I. and Ushikubi, F. and Hasebe, N.

Circulation Journal   77 ( 4 )   1053 - 1062   2013年

Apurinic/apyrimidinic endonucelase 1 maintains adhesion of endothelial progenitor cells and reduces neointima formation

Yamauchi, A. and Kawabe, J.-I. and Kabara, M. and Matsuki, M. and Asanome, A. and Aonuma, T. and Ohta, H. and Takehara, N. and Kitagawa, T. and Hasebe, N.

American Journal of Physiology - Heart and Circulatory Physiology   305 ( 8 )   H1158 - H1167   2013年

The intrinsic prostaglandin E2-EP4 system of the renal tubular epithelium limits the development of tubulointerstitial fibrosis in mice 査読

Nakagawa N, Yuhki K, Kawabe J, Fujino T, Takahata O, Kabara M, Abe K, Kojima F, Kashiwagi H, Hasebe N, Kikuchi K, Sugimoto Y, Narumiya S, Ushikubi F.

Kidney Int   82 ( (2) )   158 - 171   2012年4月

The intrinsic prostaglandin E<inf>2</inf>-EP<inf>4</inf> system of the renal tubular epithelium limits the development of tubulointerstitial fibrosis in mice

Nakagawa, N. and Yuhki, K.-I. and Kawabe, J.-I. and Fujino, T. and Takahata, O. and Kabara, M. and Abe, K. and Kojima, F. and Kashiwagi, H. and Hasebe, N. and Kikuchi, K. and Sugimoto, Y. and Narumiya, S. and Ushikubi, F.

Kidney International   82 ( 2 )   158 - 171   2012年

A case of idiopathic systemic capillary leak syndrome with high serum levels of G-CSF on exacerbation. 査読

Nakagawa N, Ota H, Tanabe Y, Kabara M, Matsuki M, Chinda J, Sakamoto N, Fujino T, Takehara N, Takeuchi T, Kawabe J, Sato N, Kawamura Y, Fukuhara T, Ikuta K, Kikuchi K, Hasebe N.

Intern Med   50 ( 6 )   597 - 600   2011年4月

Clinical and genetic investigation of a Japanese family with cardiac fabry disease. Identification of a novel α-galactosidase A missense mutation (G195V). 査読

Nakagawa N, Maruyama H, Ishihara T, Seino U, Kawabe J, Takahashi F, Kobayashi M, Yamauchi A, Sasaki Y, Sakamoto N, Ota H, Tanabe Y, Takeuchi T, Takenaka T, Kikuchi K, Hasebe N.

Int Heart J   52 ( 5 )   308 - 311   2011年4月

Clinical and genetic investigation of a Japanese family with cardiac fabry disease: Identification of a novel α-galactosidase a missense mutation (G195V)

Nakagawa, N. and Maruyama, H. and Ishihara, T. and Seino, U. and Kawabe, J. and Takahashi, F. and Kobayashi, M. and Yamauchi, A. and Sasaki, Y. and Sakamoto, N. and Ota, H. and Tanabe, Y. and Takeuchi, T. and Takenaka, T. and Kikuchi, K. and Hasebe, N.

International Heart Journal   52 ( 5 )   308 - 311   2011年

A Case of Idiopathic Systemic Capillary Leak Syndrome with High Serum Levels of G-CSF on Exacerbation

Nakagawa, N. and Ota, H. and Tanabe, Y. and Kabara, M. and Matsuki, M. and Chinda, J. and Sakamoto, N. and Fujino, T. and Takehara, N. and Takeuchi, T. and Kawabe, J.-I. and Sato, N. and Kawamura, Y. and Fukuhara, T. and Ikuta, K. and Kikuchi, K. and Hasebe, N.

Internal Medicine   50 ( 6 )   597 - 600   2011年

Roles of prostanoids in the pathogenesis of cardiovascular diseases: Novel insights from knockout mouse studies

Yuhki, K.-I. and Kojima, F. and Kashiwagi, H. and Kawabe, J.-I. and Fujino, T. and Narumiya, S. and Ushikubi, F.

Pharmacology and Therapeutics   129 ( 2 )   195 - 205   2011年

Hedgehog promotes neovascularization in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells. 査読

Nakamura N, Sasaki J, Mizukami Y, Sugiyama Y, Yamazaki M, Fujii R, Kawamoto T, Koizumi K, Sato K, Fujiya M, Sasaki K, Tanno S, Okumura T, Shimizu N, Kawabe J, Karasaki H, Kono T, Ii M, Bardeesy N, Chung D C, Kohgo Y.

ProsOne   5 ( (1) )   e8824 - e8835   2010年4月

Prostaglandin I2 promotes recruitment of endothelial progenitor cells and limits vascular remodeling. 査読

Kawabe J, Yuhki KI, Okada M, Kanno T, Yamauchi A, Tashiro N, Sasaki T, Okumura S, Nakagawa N, Aburakawa Y, Takehara N, Fujino T, Hasebe N, Narumiya S, Ushikubi F

Atheroscler. Thromb Vasc Biol   30 ( (3) )   464 - 470   2010年4月

Hedgehog promotes neovascularization in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells

Nakamura, K. and Sasajima, J. and Mizukami, Y. and Sugiyama, Y. and Yamazaki, M. and Fujii, R. and Kawamoto, T. and Koizumi, K. and Sato, K. and Fujiya, M. and Sasaki, K. and Tanno, S. and Okumura, T. and Shimizu, N. and Kawabe, J.-I. and Karasaki, H. and Kono, T. and Ii, M. and Bardeesy, N. and Chung, D.C. and Kohgo, Y.

PLoS ONE   5 ( 1 )   e8824   2010年

Prostaglandin I2 promotes recruitment of endothelial progenitor cells and limits vascular remodeling

Kawabe, J.-I. and Yuhki, K.-I. and Okada, M. and Kanno, T. and Yamauchi, A. and Tashiro, N. and Sasaki, T. and Okumura, S. and Nakagawa, N. and Aburakawa, Y. and Takehara, N. and Fujino, T. and Hasebe, N. and Narumiya, S. and Ushikubi, F.

Arteriosclerosis, Thrombosis, and Vascular Biology   30 ( 3 )   464 - 470   2010年

Roles of prostanoids in the pathogenesis of cardiovascular diseases

Yuhki, K. and Kashiwagi, H. and Kojima, F. and Kawabe, J. and Ushikubi, F.

International Angiology   29 ( 2 SUPPL. 1 )   19 - 27   2010年

Prostacyclin in vascular diseases - Recent insights and future perspectives

Kawabe, J. and Ushikubi, F. and Hasebe, N.

Circulation Journal   74 ( 5 )   836 - 843   2010年

Transplanting normal vascular proangiogenic cells to tumor-bearing mice triggers vascular remodeling and reduces hypoxia in tumors

Sasajima, J. and Mizukami, Y. and Sugiyama, Y. and Nakamura, K. and Kawamoto, T. and Koizumi, K. and Fujii, R. and Motomura, W. and Sato, K. and Suzuki, Y. and Tanno, S. and Fujiya, M. and Sasaki, K. and Shimizu, N. and Karasaki, H. and Kono, T. and Kawabe, J.-I. and Ii, M. and Yoshiara, H. and Kamiyama, N. and Ashida, T. and Bardeesy, N. and Chung, D.C. and Kohgo, Y.

Cancer Research   70 ( 15 )   6283 - 6292   2010年

Brugada syndrome case: Difficult differentiation between a concealed form and tricyclic antidepressant-induced Brugada sign

Tashiro, N. and Sato, N. and Talib, A.K. and Talib, A.K. and Saito, E. and Okura, M. and Yamaki, M. and Nakagawa, N. and Sakamoto, N. and Ota, H. and Tanabe, Y. and Takeuchi, T. and Akasaka, K. and Kawabe, J. and Kawamura, Y. and Hasebe, N.

Internal Medicine   48 ( 17 )   1535 - 1539   2009年

Administration of VEGF receptor tyrosine kinase inhibitor increases VEGF production causing angiogenesis in human small-cell lung cancer xenografts. 査読

Sasaki T, Tanno S, Shibukawa K, Osanai S, Kawabe J, Ohsaki Y,

Int J Oncol.   33 ( (3) )   525 - 532   2008年4月

Administration of VEGF receptor tyrosine kinase inhibitor increases VEGF production causing angiogenesis in human small-cell lung cancer xenografts

Sasaki, T. and Tanno, S. and Shibukawa, K. and Osanai, S. and Kawabe, J. and Ohsaki, Y.

International Journal of Oncology   33 ( 3 )   525 - 532   2008年

Disruption of type 5 adenylyl cyclase enhances desensitization of cyclic adenosine monophosphate signal and increases Akt signal with chronic catecholamine stress. 査読

Okumura S, Vatner DE, Kurotani R, Bai Y, Gao S, Yuan Z, Iwatsubo K, Ulucan C, Kawabe J, Ghosh K, Vatner SF, Ishikawa Y,

Circulation   116   1776 - 1783   2007年4月

Disruption of type 5 adenylyl cyclase enhances desensitization of cyclic adenosine monophosphate signal and increases Akt signal with chronic catecholamine stress

Okumura, S. and Vatner, D.E. and Kurotani, R. and Bai, Y. and Gao, S. and Yuan, Z. and Iwatsubo, K. and Ulucan, C. and Kawabe, J.-I. and Ghosh, K. and Vatner, S.F. and Ishikawa, Y.

Circulation   116 ( 16 )   1776 - 1783   2007年

Caveolin regulates microtubule polymerization in the vascular smooth muscle cells. 査読

Kawabe J, Okumura S, Nathanson MA, Hasebe N, Ishikawa Y

Biochem Biophys Res Com   342   164 - 169   2006年4月

Caveolin regulates microtubule polymerization in the vascular smooth muscle cells

Kawabe, J.-I. and Okumura, S. and Nathanson, M.A. and Hasebe, N. and Ishikawa, Y.

Biochemical and Biophysical Research Communications   342 ( 1 )   164 - 169   2006年

Role of prostanoids in inflammatory tachycardia: A reply to the letter of Dr. Eugene Nalivaiko [2]

Yuhki, K.-I. and Kawabe, J.-I. and Ushikubi, F.

American Journal of Physiology - Regulatory Integrative and Comparative Physiology   290 ( 6 )   2006年

Fat, keeping the heart healthy?　 査読

Yuhki K, Kawabe J , Ushikubi H

Nat Med   1048 - 1049   2005年4月

Fat, keeping the heart healthy?

Yuhki, K.-I. and Kawabe, J.-I. and Ushikubi, F.

Nature Medicine   11 ( 10 )   1048 - 1049   2005年

Translocation of caveolin regulates stretch-induced ERK activity in vascular smooth muscle cells. 査読

Kawabe J, Okumura S, Lee MC, Sadoshima J, and Ishikawa Y.

Am J Physiol Heart Circ Physiol   286 ( (5) )   H1845 - H1852   2004年4月

A cardiac sodium channel mutation identified in Brugada syndrome associated with atrial standstill. 査読

Takehara N, Makita N, Kawabe J , Sato N, Kawamura Y, Kitabatake A, and Kikuchi K,

J Intern Med   255   137 - 142   2004年4月

Insulin resistance in skeletal muscles of caveolin-3-null mice. 査読

Oshikawa J, Otsu K, Toya Y, Tsunematsu T, Hankins R, Kawabe J, Minamisawa S, Umemura S, Hagiwara Y, and Ishikawa Y.

Proc Natl Acad Sci U S A   101 ( (34) )   12670 - 12675   2004年4月

Thermal treatment attenuates neointimal thickening with enhanced expression of heat-shock protein 72 and suppression of oxidative stress. 査読

Okada M, Hasebe N, Aizawa Y, Izawa K, Kawabe J, and Kikuchi K

Circulation   109 ( (14) )   1763 - 1768   2004年4月

Insulin resistance in skeletal muscles of caveolin-3-null mice

Oshikawa, J. and Otsu, K. and Toya, Y. and Tsunematsu, T. and Hankins, R. and Kawabe, J.-I. and Minamisawa, S. and Umemura, S. and Hagiwara, Y. and Ishikawa, Y.

Proceedings of the National Academy of Sciences of the United States of America   101 ( 34 )   12670 - 12675   2004年

Thermal Treatment Attenuates Neointimal Thickening with Enhanced Expression of Heat-Shock Protein 72 and Suppression of Oxidative Stress

Okada, M. and Hasebe, N. and Aizawa, Y. and Izawa, K. and Kawabe, J.-I. and Kikuchi, K.

Circulation   109 ( 14 )   1763 - 1768   2004年

Translocation of caveolin regulates stretch-induced ERK activity in vascular smooth muscle cells

Kawabe, J.-I. and Okumura, S. and Lee, M.-C. and Sadoshima, J. and Ishikawa, Y.

American Journal of Physiology - Heart and Circulatory Physiology   286 ( 5 55-5 )   H1845 - H1852   2004年

A cardiac sodium channel mutation identified in Brugada syndrome associated with atrial standstill

Takehara, N. and Makita, N. and Kawabe, J. and Sato, N. and Kawamura, Y. and Kitabatake, A. and Kikuchi, K.

Journal of Internal Medicine   255 ( 1 )   137 - 142   2004年

Effect of -adrenoceptor antagonist and ACE inhibitor on hypertension-associated changes in AC type V messenger RNA expression in SHR. 査読

Fujino T, Hasebe N, Kawabe J , Fujita M, Fukuzawa J, Tobise K, and Kikuchi K.

J Cardiovasc Pharmacol,   41   720 - 725   2003年4月

Type 5 AC disruption alters not only sympathetic but also parasympathetic and Ca-mediated cardiac regulation 査読

Okumura S, Kawabe J et al)

Circ Res   93   364 - 371   2003年4月

Nicotinic acetylcholine receptor alpha 7 regulates cAMP signal within lipid rafts 査読

Oshikawa J, Toya Y, Fujita T, Egawa M, Kawabe J , Umemura S, and Ishikawa Y

Am J Physiol Heart Circ Physiol   285   C567 - C574   2003年4月

Disruption of type 5 adenylyl cyclase gene preserves cardiac function against pressure overload. 査読

Okumura S, Takagi G, Kawabe J , et al

Proc Natl Acad Sci U S A,   100   9986 - 9990   2003年4月

Motor dysfunction in type 5 adenylyl cyclase-null mice.　 査読

Iwamoto T, Okumura S, Iwatsubo K, Kawabe J , et al

J Biol Chem,   278   6936 - 6940   2003年4月

Nicotinic acetylcholine receptor α<inf>7</inf> regulates cAMP signal within lipid rafts

Oshikawa, J. and Toya, Y. and Fujita, T. and Egawa, M. and Kawabe, J. and Umemura, S. and Ishikawa, Y.

American Journal of Physiology - Cell Physiology   285 ( 3 54-3 )   C567 - C574   2003年

Effect of β-adrenoceptor antagonist and angiotensin-converting enzyme inhibitor on hypertension-associated changes in adenylyl cyclase type V messenger RNA expression in spontaneously hypertensive rats

Fujino, T. and Hasebe, N. and Kawabe, J.-I. and Fujita, M. and Fukuzawa, J. and Tobise, K. and Kikuchi, K.

Journal of Cardiovascular Pharmacology   41 ( 5 )   720 - 725   2003年

Motor dysfunction in type 5 adenylyl cyclase-null mice

Iwamoto, T. and Okumura, S. and Iwatsubo, K. and Kawabe, J.-I. and Ohtsu, K. and Sakai, I. and Hashimoto, Y. and Izumitani, A. and Sango, K. and Ajiki, K. and Toya, Y. and Umemura, S. and Goshima, Y. and Arai, N. and Vatner, S.F. and Ishikawa, Y.

Journal of Biological Chemistry   278 ( 19 )   16936 - 16940   2003年

Disruption of type 5 adenylyl cyclase gene preserves cardiac function against pressure overload

Okumura, S. and Takagi, G. and Kawabe, J.-I. and Yang, G. and Lee, M.-C. and Hong, C. and Liu, J. and Vatner, D.E. and Sadoshima, J. and Vatner, S.F. and Ishikawa, Y.

Proceedings of the National Academy of Sciences of the United States of America   100 ( 17 )   9986 - 9990   2003年

Type 5 adenylyl cyclase disruption alters not only sympathetic but also parasympathetic and calcium-mediated cardiac regulation

Okumura, S. and Kawabe, J.-I. and Yatani, A. and Takagi, G. and Lee, M.-C. and Hong, C. and Liu, J. and Takagi, I. and Sadoshima, J. and Vatner, D.E. and Vatner, S.F. and Ishikawa, Y.

Circulation Research   93 ( 4 )   364 - 371   2003年

Mg reduces myocardial infarct size via enhancement of ade mechanism in rabbits. 査読

Matsusaka T, Hasebe N, Jin YT, Kawabe J , and Kikuchi K

Cardiovasc Res,   54   568 - 575   2002年4月

Down-regulation of NO accumulation by COX-2 induction and TXA2 production in interleukin-1b-stimulated rat aortic smooth muscle cells. 査読

Shiokoshi T, Ohsaki Y, Kawabe J , Fujino T, and Kikuchi K.)

J Hypertens,   20   455 - 461   2002年4月

Magnesium reduces myocardial infarct size via enhancement of adenosine mechanism in rabbits

Matsusaka, T. and Hasebe, N. and Jin, Y.-T. and Kawabe, J. and Kikuchi, K.

Cardiovascular Research   54 ( 3 )   568 - 575   2002年

Downregulation of nitric oxide accumulation by cyclooxygenase-2 induction and thromboxane A<inf>2</inf> production in interleukin-1β-stimulated rat aortic smooth muscle cells

Shiokoshi, T. and Ohsaki, Y. and Kawabe, J. and Fujino, T. and Kikuchi, K.

Journal of Hypertension   20 ( 3 )   455 - 461   2002年

Pioglitazone enhances cytokine-induced apoptosis in vascular smooth muscle cells and reduces intimal hyperplasia. 査読

Aizawa Y, Kawabe J , Hasebe N, Takehara N, and Kikuchi K.

Circulation   104   455 - 460   2001年4月

Changes in caveolin subtype protein expression in aging rat organs. 査読

Kawabe J , Grant BS, Yamamoto M, Schwencke C, Okumura S, and Ishikawa Y.

Mol Cell Endocrinol,   176   91 - 95   2001年4月

Pioglitazone enhances cytokine-induced apoptosis in vascular smooth muscle cells and reduces intimal hyperplasia

Aizawa, Y. and Kawabe, J.-I. and Hasebe, N. and Takehara, N. and Kikuchi, K.

Circulation   104 ( 4 )   455 - 460   2001年

Changes in caveolin subtype protein expression in aging rat organs

Kawabe, J.-I. and Grant, B.S. and Yamamoto, M. and Schwencke, C. and Okumura, S. and Ishikawa, Y.

Molecular and Cellular Endocrinology   176 ( 1-2 )   91 - 95   2001年

Glucose modifies the cross-talk between insulin and the beta-adrenergic ignaling system in vascular smooth muscle cells. 査読

Kawabe J , Aizawa Y, Takehara N, Hasebe N, and Kikuchi K.

J Hypertens,   18   1457 - 1464   2000年4月

High glucose attenuates insulin-induced MKP-1 expression in vascular smooth muscle cells.. 査読

Takehara N, Kawabe J , Aizawa Y, Hasebe N, and Kikuchi K

Biochim Biophys Acta   1497   244 - 252   2000年4月

High glucose attenuates insulin-induced mitogen-activated protein kinase phosphatase-1 (MKP-1) expression in vascular smooth muscle cells

Takehara, N. and Kawabe, J.-I. and Aizawa, Y. and Hasebe, N. and Kikuchi, K.

Biochimica et Biophysica Acta - Molecular Cell Research   1497 ( 2 )   244 - 252   2000年

Glucose modifies the cross-talk between insulin and the β-adrenergic signalling system in vascular smooth muscle cells

Kawabe, J.-I. and Aizawa, Y. and Takehara, N. and Hasebe, N. and Kikuchi, K.

Journal of Hypertension   18 ( 10 )   1457 - 1464   2000年

Lovastatin prevents angiotensin II-induced cardiac hypertrophy in cultured neonatal rat heart cells. 査読

Oi S, Haneda T, Osaki J, Kashiwagi Y, Nakamura Y, Kawabe J , and Kikuchi K

Eur J Pharmacol,   376   139 - 148   1999年4月

Lovastatin prevents angiotensin II-induced cardiac hypertrophy in cultured neonatal rat heart cells

Oi, S. and Haneda, T. and Osaki, J. and Kashiwagi, Y. and Nakamura, Y. and Kawabe, J. and Kikuchi, K.

European Journal of Pharmacology   376 ( 1-2 )   139 - 148   1999年

Enhanced expression of heparin-binding EGF-like growth factor and its receptor in hypertrophied left ventricle of SHR. 査読

Fujino T, Hasebe N, Fujita M, Takeuchi K, Kawabe J , Tobise K, Higashiyama S, Taniguchi N, and Kikuchi K.

Cardiovasc Res,   38   365 - 374   1998年4月

Enhanced expression of heparin-binding EGF-like growth factor and its receptor in hypertrophied left ventricle of spontaneously hypertensive rats

Fujino, T. and Hasebe, N. and Fujita, M. and Takeuchi, K. and Kawabe, J.-I. and Tobise, K. and Higashiyama, S. and Taniguchi, N. and Kikuchi, K.

Cardiovascular Research   38 ( 2 )   365 - 374   1998年

Regulation of adenylyl cyclase isoforms by N-alkanols 査読

Ebina T, Toya Y, Kawabe J, and Ishikawa Y.

J Cell Biochem   66   450 - 456   1997年4月

Caveolin interaction with PKC. Isoenzyme-dependent regulation of kinase activity by the caveolin scaffolding domain peptide., 査読

Oka N, Yamamoto M, Schwencke C, Kawabe J, Ebina T, Ohno S, Couet J, Lisanti MP, and Ishikawa Y.

J Biol Chem   272   33416 - 33421   1997年4月

Isoform-dependent activation of adenylyl cyclase by proteolysis. 査読

Ebina T, Toya Y, Oka N, Kawabe J, Schwencke C, and Ishikawa

FEBS Lett,   401   223 - 226   1997年4月

Conformation-dependent activation of type II adenylyl cyclase by protein kinase C. 査読

Ebina T, Kawabe J, Katada T, Ohno S, Homcy CJ, and Ishikawa Y

J Cell Biochem   64   492 - 498   1997年4月

Isoform-specific regulation of adenylyl cyclase by oxidized catecholamines., 査読

Ebina T, Toya Y, Oka N, Schwencke C, Kawabe J, and Ishikawa Y

J Mol Cell Cardiol   29   1247 - 1254   1997年4月

Caveolin interaction with protein kinase C. Isoenzyme-dependent regulation of kinase activity by the caveolin scaffolding domain peptide

Oka, N. and Yamamoto, M. and Schwencke, C. and Kawabe, J.-I. and Ebina, T. and Ohno, S. and Couet, J. and Lisanti, M.P. and Ishikawa, Y.

Journal of Biological Chemistry   272 ( 52 )   33416 - 33421   1997年

Erratum: Isoform-dependent activation of adenylyl cyclase by proteolysis (FEBS 18081) (FEBS Letters 401 (1997) (223-226) PII: S0014579396014755)

Ebina, T. and Toya, Y. and Oka, N. and Kawabe, J.-I. and Schwencke, C. and Ishikawa, Y.

FEBS Letters   411 ( 2-3 )   393 - 393   1997年

Isoform-specific regulation of adenylyl cyclase by oxidized catecholamines

Ebina, T. and Toya, Y. and Oka, N. and Schwencke, C. and Kawabe, J.-I. and Ishikawa, Y.

Journal of Molecular and Cellular Cardiology   29 ( 4 )   1247 - 1254   1997年

Secretion of atrial natriuretic peptide from the left ventricle and heart in patients with hypertrophic cardiomyopathy: relationship with hemodynamic and echocardiographic profiles

Ishii, Y. and Kawashima, E. and Kawabe, J. and Kikuchi, K.

Journal of cardiology   30 ( 1 )   19 - 28   1997年

Isoform-dependent activation of adenylyl cyclase by proteolysis

Ebina, T. and Toya, Y. and Oka, N. and Kawabe, J.-I. and Schwencke, C. and Ishikawa, Y.

FEBS Letters   401 ( 2-3 )   223 - 226   1997年

Conformation-dependent activation of type II adenylyl cyclase by protein kinase C

Ebina, T. and Kawabe, J.-I. and Katada, T. and Ohno, S. and Homcy, C.J. and Ishikawa, Y.

Journal of Cellular Biochemistry   64 ( 3 )   492 - 498   1997年

Regulation of adenylyl cyclase isoforms by n-alkanols

Ebina, T. and Toya, Y. and Kawabe, J.-I. and Ishikawa, Y.

Journal of Cellular Biochemistry   66 ( 4 )   450 - 456   1997年

Soluble adenylyl cyclase from Spodoptera frugiperda (Sf9) cells. Purification and biochemical characterization. 査読

Kawabe J, 　Toya Y, Schwencke C, Oka N, Ebina T, and Ishikawa Y.

J Biol Chem   271   20132 - 20137   1996年4月

Regulation of type V adenylyl cyclase by PMA-sensitive and –insensitive protein kinase C isoenzymes in intact cells. 査読

Kawabe J, Ebina T, Toya Y, Oka N, Schwencke C, Duzic E, and Ishikawa Y.

FEBS Lett,   384   273 - 276   1996年4月

Soluble adenylyl cyclase from Spodoptera frugiperda (Sf9) cells: Purification and biochemical characterization

Kawabe, J.-I. and Toya, Y. and Schwencke, G. and Oka, N. and Ebina, T. and Ishikawa, Y.

Journal of Biological Chemistry   271 ( 33 )   20132 - 20137   1996年

Errata: Erratum to 'Multiplicity in type V adenylylcyclase: Type V-a and type V-b' (Molecular and Cellular Endocrinology 110 (1995) 45)

Iwami, G. and Akanuma, M. and Kawabe, J. and Cannon, P.J. and Homcy, C.J. and Ishikawa, Y.

Molecular and Cellular Endocrinology   122 ( 1 )   111 - 112   1996年

Regulation of type V adenylyl cyclase by PMA-sensitive and -insensitive protein kinase C isoenzymes in intact cells

Kawabe, J.-I. and Ebina, T. and Toya, Y. and Oka, N. and Schwencke, G. and Duzic, E. and Ishikawa, Y.

FEBS Letters   384 ( 3 )   273 - 276   1996年

Regulation of adenylyl cyclase by protein kinase A. 査読

Iwami G, Kawabe J, Ebina T, Cannon PJ, Homcy CJ, and Ishikawa Y.

J Biol Chem   270   12481 - 12484   1995年4月

Multiplicity in type V adenylylcyclase: type V-a and type V-b., 査読

Iwami G, Akanuma M, Kawabe J,　Cannon PJ, Homcy CJ, and Ishikawa Y.

Mol Cell Endocrinol   110   43 - 47   1995年4月

Multiplicity in type V adenylylcyclase: type V-a and type V-b

Iwami, G. and Akanuma, M. and Kawabe, J. and Cannon, P.J. and Homcy, C.J. and Ishikawa, Y.

Molecular and Cellular Endocrinology   110 ( 1-2 )   43 - 47   1995年

Regulation of adenylyl cyclase by protein kinase A

Iwami, G. and Kawabe, J.-I. and Ebina, T. and Cannon, P.J. and Homcy, C.J. and Ishikawa, Y.

Journal of Biological Chemistry   270 ( 21 )   12481 - 12484   1995年

A novel peptide inhibitor of adenylyl cyclase (AC). A peptide from type V AC directly inhibits AC catalytic activity. 査読

Kawabe J, Ebina T, Ismail S, Kitchen DB, Homcy CJ, and Ishikawa Y

J Biol Chem   269   24906 - 24911   1994年4月

Differential activation of adenylyl cyclase by protein kinase C isoenzymes. 査読

Kawabe J, Iwami G, Ebina T, Ohno S, Katada T, Ueda Y, Homcy CJ, and Ishikawa Y.

J Biol Chem   269   6554 - 6558   1994年4月

Differential activation of adenylyl cyclase by protein kinase C isoenzymes

Kawabe, J.-I. and Iwami, G. and Ebina, T. and Ohno, S. and Katada, T. and Ueda, Y. and Homcy, C.J. and Ishikawa, Y.

Journal of Biological Chemistry   269 ( 24 )   16554 - 16558   1994年

Erratum: Differential activation of adenylyl cyclase by protein kinase C isoenzymes (Journal of Biological Chemistry (1994) 269 (16554-16558))

Kawabe, J.-I. and Iwami, G. and Ebina, T. and Ohno, S. and Katada, T. and Ueda, Y. and Homcy, C.J. and Ishikawa, Y.

Journal of Biological Chemistry   269 ( 36 )   22912 - 22912   1994年

A novel peptide inhibitor of adenylyl cyclase (AC). A peptide from type V AC directly inhibits AC catalytic activity

Kawabe, J.-I. and Ebina, T. and Ismail, S. and Kitchen, D.B. and Homey, C.J. and Ishikawa, Y.

Journal of Biological Chemistry   269 ( 40 )   24906 - 24911   1994年

In vivo generation of an adenylylcyclase isoform with a half-molecule motif. 査読

Katsushika S, Kawabe J, Homcy CJ, and Ishikawa Y.

J Biol Chem   268   2273 - 2276   1993年4月

Adenylylcyclase: characterization in the heart and its regulation in heart failure. 査読

Homcy CJ, Katsushika S, Kawabe J. et al

Hypertens Res   16   79 - 83   1993年4月

In vivo generation of an adenylylcyclase isoform with a half-molecule motif

Katsushika, S. and Kawabe, J.-I. and Homcy, C.J. and Ishikawa, Y.

Journal of Biological Chemistry   268 ( 4 )   2273 - 2276   1993年

Adenylylcyclase: Characterization in the Heart and Its Regulation in Heart Failure

Homcy, C.J. and Ishikawa, Y. and Katsushika, S. and Kawabe, J.-I. and Ishikawa, Y. and Kiuchi, K. and Komamura, K. and Vatner, D.E. and Vatner, S.F.

Hypertension Research   16 ( 2 )   79 - 83   1993年

Role of endothelium in biphasic hypoxic response of the isolated poumonary artery in the rat

Ogawa, Y. and Kawabe, J.-I. and Onodera, S. and Tobise, K. and Morita, K. and Harada, T. and Hirayama, T. and Takeda, A.

JAPANESE CIRCULATION JOURNAL   57 ( 3 )   228 - 236   1993年

Isolation and characterization of a novel cardiac adenylylcyclase cDNA. 査読

Ishikawa Y, Katsushika S, Chen L, Halnon NJ, Kawabe J , and Homcy CJ.

J Biol Chem   267   13553 - 13557   1992年4月

Down-regulation of PKC potentiates ANP-stimulated cGMP accumulation in vascular smooth-muscle cells., 査読

Kawabe J, Ohsaki Y, and Onodera S.

Biochim Biophys Acta   1175   81 - 87   1992年4月

Cloning and characterization of a sixth AC isoform: types V and VI constitute a subgroup within the mammalian AC family　 査読

Katsushika S, Chen L, Kawabe J , Nilakantan R, Halnon NJ, Homcy CJ, and Ishikawa Y.

Proc Natl Acad Sci U S A   89   8774 - 8778   1992年4月

Down-regulation of protein kinase C potentiates atrial natriuretic peptide-stimulated cGMP accumulation in vascular smooth-muscle cells

Kawabe, J.-i. and Ohsaki, Y. and Onodera, S.

BBA - Molecular Cell Research   1175 ( 1 )   81 - 87   1992年

Role of endothelium in hypoxia-induced contraction of isolated rat pulmonary artery

Ogawa, Y. and Kawabe, J. and Morita, K. and Harada, T. and Hirayama, T. and Takeda, A. and Tobise, K. and Onodera, S.

Japanese Journal of Pharmacology   58 ( SUPPL. 2 )   1992年

Cloning and characterization of a sixth adenylyl cyclase isoform: Types V and VI constitute a subgroup within the mammalian adenylyl cyclase family

Katsushika, S. and Chen, L. and Kawabe, J.-I. and Nilakantan, R. and Halnon, N.J. and Homcy, C.J. and Ishikawa, Y.

Proceedings of the National Academy of Sciences of the United States of America   89 ( 18 )   8774 - 8778   1992年

Isolation and characterization of a novel cardiac adenylylcyclase cDNA

Ishikawa, Y. and Katsushika, S. and Chen, L. and Halnon, N.J. and Kawabe, J.-I. and Homcy, C.J.

Journal of Biological Chemistry   267 ( 19 )   13553 - 13557   1992年

The Combination Effect of Caffeine and Cisplatin on a Human Lung Cancer Cell Line

Yoshinobu, O, I. and Toshiaki, F. and Jun-ichi, K. and Hiroyuki, M. and Sokichi, O.

Japanese Journal of Lung Cancer   30 ( 3 )   341 - 349   1990年

Effects of chronic volume loading on atrial natriuretic peptide release in human

Kawabe, J. and Ohsaki, Y. and Onodera, S. and Inoue, H. and Hirayama, T. and Akiba, Y. and Osanai, S. and Sakai, H. and Ishida, S. and Nakano, H.

Kokyu to junkan. Respiration &amp; circulation   38 ( 11 )   1121 - 1125   1990年

Cefdinir in respiratory tract infection

Matsumoto, H. and Akiba, Y. and Osanai, S. and Ishida, S. and Kawabe, J. and Osaki, Y. and Fujikane, T. and Sasakli, N. and Onodera, S. and Nakano, H.

CHEMOTHERAPY   37   257 - 262   1989年

最新の治療ストラテジー　ベーターブロッカーの使い方　臨床雑誌内科

竹原有史、川辺淳一、長谷部直幸、菊池健次郎（ 担当： 共著）

南江堂  2000年4月 

カルシウム拮抗薬の特徴と使用法　　　

川辺淳一、長谷部直幸、菊池健次郎

診断と治療   94 ( (3) )   391 - 395   2006年4月

温熱による新生内膜脂厚の抑制効果－熱ショック蛋白の発現と酸化ストレスの抑制と役割－　

岡田　基、長谷部直幸、会澤佳昭、井澤和眞、川辺淳一、菊池健次郎

血　圧   11   263 - 266   2004年4月

JNC７の長所と短所　　　　　　　　　　　　　　　　　　　　　　　　

川辺淳一、長谷部直幸、菊池健次郎

循環器内科   56 ( (5) )   507 - 511   2004年4月

Nerve Growth Factor Induces Maturation of Vasa Vasorum Neovasculature in Injured Vascular walls

Akira Asanome, Junichi Kawabe, Motoki Matsuki, Atsushi Yamauchi, Naofumi Takehara, Motoi Okada, Naoyuki Hasebe

日本循環器学会 

Enhanced Inhibition of Neointimal Hyperplasia by Overexpression of Apurinic/apyrimidinic Endonuclease (APE1) in Endothelial Progenitor Cells 国際会議

Atsushi Yamauchi, Jun-ichi Kawabe, Maki Kabara, Akira Asanome,Motoki Matsuki, Naoki Nakagawa, Naofumi Takehara, Naoyuki Hasebe

日本血管生物学会 

Peripheral Nerve is critical for Vasa Vasorum Maturation in Injured Vascular Walls. -Effects of SubstanceP on Pericytes-

Akira Asanome, Junichi Kawabe, Maki Kabara, Motoki Matsuki, Atsushi Yamauchi, Naoki Nakagawa, Hisanobu Ohta, Naofumi akehara, Naoyuki Hasebe

日本血管生物学会 

内皮前駆細胞（EPC）を介したプロスタサイクリンの下肢虚血改善作用　－血管周細胞分化による血管新生効果－

浅野目　晃、川辺　淳一、山内　敦司、竹原　有史、長谷部　直幸

日本脈管学会　総会 

The cardioprotective effect of prostaglandin E2/EP4 system is important for the late phase preconditioning 国際会議

T Kanno, J Kawabe, Yuhki, N Takehara, F Ushikubi, N Hasebe

AHA （アメリカ心臓病学会) 

Prostacylcin augments endotherial progenitor cell functions and rescue peripheral ischemia

M Okada, J Kawabe, Y Aburakawa, T Kanno, A　Yamauchi, N Nakagawa, N Tashiro, MYamaki, F　Ushikubi and N Hasebe

日本循環器学会 

Prostacyclin System in Endothelial Progenitor Cells is crucial for Regulation of Vascular Remodeling through their recruitment to injured vascular walls.

Yamauchi A, Kawabe J, Kobayashi M, Kannno T, Ushikubi F, Hasebe N, P

日本循環器学会 

Prostacyclin relieves peripheral ischemia through enhancement of critical functions of endothelial progenitor cells 国際会議

M Okada, J Kawabe, Y Aburakawa, T Kanno, A　Yamauchi, N Nakagawa, N Tashiro, MYamaki, F　Ushikubi and N Hasebe

AHA （アメリカ心臓病学会） 

Impaired functional endothelial progenitor cells inhibited growth of Prostacycline signaling as a target for cancer therapy -. 国際会議

Sasaki T, Okumura S, Shibukawa K, Osanai S, Kawabe J, Ohsaki Y

AACR(アメリカ癌研究学会)  

Role of Autocrine Prostacyclin System in Crucial Functions of Endothelial Progenitor Cells.

Kawabe J, Kanno T, Tashiro N, Okada M, Yuhki K, Ushikubi F, Hasebe N

日本循環器学会 

Decreased Susceptibility to Release of TGF-β1 from Platelet and Microalbuminuria inTXA2 Receptor Deficient Mice with Diabetes Mellitus

Fujino T, Suzuki Y, Kawabe J, Yuhki K, Fukuzawa J, Matsuki M, Nakagawa, N Hasebe N, Ushikubi F

日本循環器学会 

Deletion of prostacyclin-receptor in bone marrow attenuates differentiation of endothelial progenitor cells, and Enhances Vascular Intimal Hyperplasia Circulation. 国際会議

Kawabe J, Yuhki K, Kannno T, Hasebe N, Ushikubi F

AHA （アメリカ心臓病学会） 

Decreased susceptibility to endothelial dysfunction and glomerular remodeling in diabetes mellitus in thromboxane A2 receptor deficient mice.

Fujino T, Suzuki Y, Ｋawabe J, Nakagawa N, Yuhki K, Hasebe N, Kikuchi K, Ushikubi F

日本高血圧学会 

内皮前駆細胞分化とプロスタノイド－再生医療への応用にむけて－　

川辺淳一

第２回　名寄・士別循環器研究会　 

Decreased Susceptibility to Glomerular Regeneration in Thromboxane A2 Receptor Deficient Mice　

Fujino T, Abe K, Nakagawa N, Yuhki K, Kawabe J, Hasebe N, Kikuchi K, Ukikubi F

日本循環器学会 

Deletion of PGI2-receptor (IP) in Bone Marrow Enhances Progenitor Cells-Mediated Vascular Intimal Hyperplasia

Kawabe J, Kanno T, Yuhki K, Hasebe N, Kikuchi K, Usikubi F

日本循環器学会 

Decreased Susceptibility to Glomerular Hypertrophy and Albuminuria in Thromboxane A2 Receptor Deficient Mice.

Fujino T, Abe K, Nakagawa N, Yuhki K, Kawabe J, et al

ISHR　（国際高血圧学会） 

Thermal treatment attenuates vascular atherosclerosis and lowers blood pressure in spontaneously hypertensive rats. 国際会議

Tashiro N, Okada M, Izawa K, Aizawa Y, Kawabe J, et al

ISHR　（国際高血圧学会） 

Combination of Pitavastatin and Thermal Treatment Attenuates Cytokine-induced Monocye/macrophage Activation and Oxidative Stress. 国際会議

Okada M, Hasebe N, Tashiro N, Yamauchi A, Kawabe J Kikuchi K

ISHR　（国際高血圧学会） 

Repeated Thermal Treatment Reduces Adventitial Inflammatory Response in Arteriosclerosis. 国際会議

Okada M, Hasebe N, Tashiro N, Yamauchi A, Kawabe J Kikuchi K

ISHR　（国際高血圧学会） 

炎症性頻脈の発生機序：プロスタノイドによる心機能調節　

川辺淳一

第2回 宮崎サイエンスキャンプ　　　 

血管新生内膜形成におけるプロスタノイドの役割

川辺淳一

第８回 旭川血管リモデリング研究会  

PE-520/ Combination of pitavastatin and therminal treatment attenuates angiotensin Ⅱ-induced cellular activation and oxidative stress.

Okada M, Tashiro N, Izawa K, Kawabe J, Hasebe N, Kikuchi K

日本循環器学会 

炎症性頻脈の発生機序

川辺淳一

第７回 旭川血管リモデリング研究会　 

心血管系におけるプロスタノイドの役割

川辺淳一

第23回 病態生理研究会  

Paradoxical suppression of angiotensin II-induced vascular remodeling in impaired glutathione redox system.

Izawa K, Hasebe N, Okada M, Sumitomo K, Kawabe J, et al

日本循環器学会 

Impaired glutathione redox regulation paradoxically suppresses angiotensin Ⅱ-induced vascular remodeling 国際会議

Izawa K, Hasebe N, Okada M, Kawabe J, et al

AHA（アメリカ心臓病学会 

β-adrenergic and muscarinic regulation of the heart requires type 5 adenylyl cyclase.

Okumura S, Kawabe J, et al　

日本循環器学会 

The type 5 adenylyl cyclase mediates Ca2+-mediated regulation of Ca2+ channels in the heart.

Kawabe J, Ishikawa Y, et al　

日本循環器学会 

Disruption of the type 5 adenylyl cyclase gene preserve cardiac function against pressure overload.

Okumura S, Kawabe J, et al

日本循環器学会 

Caveolin modulates microtubule polymerization in vascular smooth muscle cells.

Kawabe J, Ishikawa Y, et al

日本循環器学会 

Translocation of caveolin regulates stretch- induced ERK activity in vascular smooth muscle cells.　　

Kawabe J, Ishikawa Y, et al

日本循環器学会 

再生医療開発にむけた間葉系幹細胞様の毛細血管周細胞の機能解明

2013年4月 - 2016年3月

基盤研究(C)

ＤＮＡ修復機構ＡＰＥ－１の心筋幹細胞に対する細胞機能再生及び虚血耐性に対する効果

2011年4月 - 2014年3月

基盤研究(C)

障害血管リモデリングおよび血管外膜微小血管新生における神経再生因子の役割

2010年4月 - 2013年3月

基盤研究(C)

骨髄由来内皮前駆細胞におけるプロスタノイドの包括的役割解明

2010年4月 - 2013年3月

基盤研究(C)

骨髄由来血管内皮前駆細胞の制御によるがん治療の検討

2008年4月 - 2011年3月

基盤研究(C)

プロスタノイドの血管病変形成における役割－骨髄細胞分化に及ぼす影響－

2006年4月 - 2009年3月

基盤研究(C)