Updated on 2025/01/20

写真a

 
SUZUKI Shigeru
 
Organization
Hospital Clinical Departments Pediatrics
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Degree

  • 医学博士 ( 2008.3   旭川医科大学 )

Research Areas

  • Life Science / Embryonic medicine and pediatrics

Education

  • Asahikawa Medical College   Graduate School, Division of Medicine

    - 2008.3

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    Country: Japan

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  • Asahikawa Medical College   Faculty of Medicine

    - 2002.3

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    Country: Japan

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Research History

  • Asahikawa Medical College   Lecturer

    2021.4

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  • Asahikawa Medical College   Assistant Professor

    2016.4 - 2021.3

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  • 旭川厚生病院   小児科   医長

    2015.4 - 2016.3

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  • Asahikawa Medical College   Assistant Professor

    2010.4 - 2015.3

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  • Asahikawa Medical College   Assistant Professor

    2010.4 - 2015.3

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  • 旭川厚生病院   小児科   医長

    2009.5 - 2010.3

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  • 旭川厚生病院   小児科   医員

    2009.4

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  • Asahikawa Medical College

    2008.4 - 2009.3

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  • Asahikawa Medical College

    2003.10 - 2004.3

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  • 旭川厚生病院   医員

    2002.10 - 2003.9

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  • Asahikawa Medical College

    2002.6 - 2002.9

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Professional Memberships

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Studying abroad experiences

  • 2013.1 - 2015.3   米国国立衛生研究所   共同研究員

Papers

  • Early Diagnosis of Wolfram Syndrome by Ophthalmologic Screening in a Patient with Type 1B Diabetes Mellitus Reviewed

    Kokumai T., Suzuki S., Nishikawa N., Yamamura H., Mukai T., Tanahashi T., Takahashi S.

    J Clin Res Pediatr Endocrinol   2024.5

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  • Impact of genetic and non-genetic factors on phenotypic diversity in NBAS-associated disease Reviewed

    Hammann N., Lenz D., Baric I., Crushell E., Vici CD, Distelmaier F., Feillet F., Freisinger P., Hempel M., Khoreva AL, Laass MW, Lacassie Y., Lainka E., Larson-Nath C., Li Z., Lipiński P., Lurz E., Mégarbané A., Nobre S., Olivieri G., Peters B., Prontera P., Schlieben LD, Seroogy CM, Sobacchi C., Suzuki S., Tran C., Vockley J., Wang JS, Wagner M., Prokisch H., Garbade SF, Kölker S., Hoffmann GF, Staufner C.

    Mol Genet Metab   2024.3

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  • A Japanese school urine screening program led to the diagnosis of KCNJ11-MODY: A case report Reviewed

    Hattori A., Okuhara K., Shimizu Y., Ohta T., Suzuki S.

    Clin Pediatr Endocrinol   2024.1

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  • Growth Hormone Injection Log Analysis with Electronic Injection Device for Qualifying Adherence to Low-Irritant Formulation and Exploring Influential Factors on Adherence Reviewed

    Takasawa K., Mabe H., Nagamatsu F., Amano N., Miyakawa Y., Sutani A., Kagawa R., Okada S., Tanahashi Y., Suzuki S., Hiroshima S., Nagasaki K., Dateki S., Takishima S., Takahashi I., Kashimada K.

    Patient Prefer Adherence   2023.8

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  • SGLT2i as a Useful Adjunctive Medication for HNF4A-MODY Reviewed

    Shigeru Suzuki, Takahide Kokumai, Akiko Furuya, Satoru Takahashi

    Diabetes Care   2023.3

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  • SGLT2i as a Useful Adjunctive Medication for HNF4A-MODY Reviewed

    Shigeru Suzuki, Takahide Kokumai, Akiko Furuya, Satoru Takahashi

    Diabetes Care   2023.3

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  • Paternally derived chromosome 6q24 triplication causes neonatal diabetes mellitus Reviewed

    Shigeru Suzuki, Kanayo Ochiai, Yuichi Nishikado

    Horm Res Paediatr   2023.2

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  • Impact of small for gestational age on type 2 diabetes in obese siblings Reviewed

    Shoma Saito, Hinako Yamamura, Takahide Kokumai, Akiko Furuya, Shigeru Suzuki, Satoru Takahashi

    Pediatr Int   2023.2

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  • Impact of small for gestational age on type 2 diabetes in obese siblings Reviewed

    Shoma Saito, Hinako Yamamura, Takahide Kokumai, Akiko Furuya, Shigeru Suzuki, Satoru Takahashi

    Pediatr Int   2023.1

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  • Early Diagnosis of Wolfram Syndrome by Ophthalmologic Screening in a Patient with Type 1B Diabetes Mellitus: A Case Report Reviewed

    Takahide Kokumai, Shigeru Suzuki, Noriko Nishikawa, Hinako Yamamura, Tokuo Mukai, Yusuke Tanahashi, Satoru Takahashi

    J Clin Res Pediatr Endocrinol   2022.8

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  • Long-term sensor-augmented pump therapy for neonatal diabetes mellitus: a case series Reviewed

    Fukuda Y., Ishii A., Kamasaki H., Fusagawa S., Terada K., Igarashi L., Kobayashi M., Suzuki S., Tsugawa T.

    Clin Pediatr Endocrinol   2022.7

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  • Long-term sensor-augmented pump therapy for neonatal diabetes mellitus: a case series Reviewed

    Yuya Fukuda, Akira Ishii, Hotaka Kamasaki, Shintaro Fusagawa, Kojiro Terada, Lisa Igarashi, Masaki Kobayashi, Shigeru Suzuki, Takeshi Tsugawa

    Clin Pediatr Endocrinol   2022.5

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  • 高身長を契機に診断に至った幼児バセドウ病の一例 Reviewed

    山本 あゆこ, 若林 伊織, 山村 日向子, 國米 崇秀, 鈴木 滋, 高橋 悟

    日本成長学会雑誌   2022.5

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  • A mutation of the β-domain in POU1F1 causes pituitary deficiency due to dominant PIT-1β expression Reviewed

    Shigeru Suzuki, Kumihiro Matsuo, Yoshiya Ito, Atsushi Kobayashi, Takahide Kokumai, Akiko Furuya, Osamu Ueda, Tokuo Mukai, Koichi Yano, Kenji Fujieda, Akimasa Okuno, Yusuke Tanahashi, Hiroshi Azuma

    Eur J Endocrinol   2021.5

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  • Investigation of TSH receptor blocking antibodies in childhood-onset atrophic autoimmune thyroiditis Reviewed

    Keisuke Nagasaki, Akie Nakamura, Takeru Yamauchi, Hotaka Kamasaki, Yosuke Hara, Junko Kanno, Satomi Koyama, Yoshiaki Ohtsu, Ikuko Takahashi, Shigeru Suzuki, Kenichi Kashimada, Toshihiro Tajima

    Clin Pediatr Endocrinol   2021.4

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  • Protein ingestion can significantly affect glucagon secretion along with blood urea nitrogen alteration in type 1 diabetes Reviewed

    Shigeru Suzuki, Takahide Kokumai, Yusuke Tanahashi, Hiroshi Azuma

    J Diabetes Investig   2021.2

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  • Bacteremia-Induced Cholestatic Jaundice as a Major Manifestation of Pneumococcal Infection in a Healthy Toddler Reviewed

    Shigeru Suzuki, Genya Taketazu, Tokuo Mukai, Hiroshi Sakata, Junichi Oki

    J Pediatr Infect Dis   2020.12

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  • A 34-year-old Japanese patient exhibiting NBAS deficiency with a novel mutation and extended phenotypic variation Reviewed

    Shigeru Suzuki, Takahide Kokumai, Akiko Furuya, Tsunehisa Nagamori, Kumihiro Matsuo, Osamu Ueda, Tokuo Mukai, Yoshiya Ito, Koichi Yano, Kenji Fujieda, Akimasa Okuno, Yusuke Tanahashi, Hiroshi Azuma

    Eur J Med Genet   2020.11

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  • ヘモグロビンA1cとグリコアルブミンの実臨床検体による精度管理と課題 小児インスリン治療研究会報告 Reviewed

    望月 美恵, 武者 育麻, 小林 浩司, 鈴木 滋, 小林 基章, 菊池 信行, 横田 一郎, 川村 智行, 浦上 達彦, 菊池 透, 杉原 茂孝, 佐々木 望, 松浦 信夫, 星野 忠夫, 雨宮 伸

    糖尿病   2020.11

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  • Increase in doses of levothyroxine at the age of 3 years and above is useful for distinguishing transient and permanent congenital hypothyroidism Reviewed

    Hinako Yamamura, Takahide Kokumai, Akiko Furuya, Shigeru Suzuki, Yusuke Tanahashi, Hiroshi Azuma

    Clin Pediatr Endocrinol   2020.10

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  • Sufficient Increment of Sulfonylurea Without Reintroduction of Insulin Ameliorates Pubertal Deterioration of Glycaemic Control in KCNJ11 Neonatal Diabetes Treated With Long-Term Sulfonylurea Reviewed

    Shigeru Suzuki, Tokuo Mukai, Takahide Kokumai, Akiko Furuya, Yusuke Tanahashi, Hiroshi Azuma

    Diabetologia   2020.8

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  • Novel TRPV6 mutations in the spectrum of transient neonatal hyperparathyroidism Reviewed

    Yoshiro Suzuki, Hirotake Sawada, Tomoko Tokumasu, Shigeru Suzuki, Shinsuke Ninomiya, Masaru Shirai, Tokuo Mukai, Claire T Saito, Gen Nishimura, Makoto Tominaga

    J Physiol Sci   2020.7

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  • 本邦における21水酸化酵素欠損症の予後調査

    棚橋 祐典, 鈴木 滋, 鹿島田 健一, 向井 徳男, 勝又 規行, 石井 智弘, 田島 敏広, 長谷川 奉延

    日本内分泌学会雑誌   2020.7

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  • 思春期早発徴候を呈しGnRHアナログ治療を先行した原発性卵巣機能不全 Reviewed

    山村 日向子, 古谷 曜子, 鈴木 滋, 棚橋 祐典, 東 寛

    日本小児科学会雑誌   2019.6

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  • SIRT1 is a transcriptional enhancer of the glucocorticoid receptor acting independently to its deacetylase activity Reviewed

    Suzuki S., Iben JR, Coon SL, Kino T.

    Mol Cell Endocrinol   2018.2

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    DOI: 10.1016/j.mce.2017.09.012

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  • NDM患者において日齢補正GAは血糖を正しく反映する:血糖値より求めた算出GAとの比較 Invited Reviewed

    鈴木 滋, 古谷曜子, 大島美保, 雨宮 聡, 中尾 厚, 和田佳子, 奥原宏治, 早野 聡, 今本 彩, 松尾公美浩, 棚橋祐典, 東 寛, 古賀正史

    臨床化学   2017.10

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  • 先天性下垂体機能低下症の新たな発症機構の解明 PIT-1β変異の機能解析

    棚橋祐典, 鈴木滋, 古谷曜子

    成長科学協会研究年報   2017.9

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  • Genome-wide Regulatory Roles of the C2H2-type Zinc Finger Protein ZNF764 on the Glucocorticoid Receptor Reviewed

    Fadda A., Syed N., Mackeh R., Papadopoulou A., Suzuki S., Jithesh PV, Kino T.

    Sci Rep   2017.1

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    DOI: 10.1038/srep41598

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  • AKT1 has dual actions on the glucocorticoid receptor by cooperating with 14-3-3 Reviewed

    Habib T., Sadoun A., Nader N., Suzuki S., Liu W., Jithesh PV, Kino T.

    Mol Cell Endocrinol   2017.1

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    DOI: 10.1016/j.mce.2016.10.002

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  • Glycemic control indicator levels at diagnosis of neonatal diabetes mellitus: Comparison with other types of insulin-dependent diabetes mellitus Reviewed

    Suzuki S., Furuya A., Tanahashi Y., Azuma H., Bando Y., Kasayama S., Koga M.

    Pediatr Diabetes   2016.12

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  • Age-Adjusted Glycated Albumin at Diagnosis is more Correlated with the Product of Age and Plasma Glucose than Plasma Glucose Alone in Patients with Neonatal Diabetes Mellitus Reviewed

    Furuya A., Suzuki S., Oshima M., Amamiya S., Nakao A., Araki M., Mizutani K., Hayano S., Ushijima K., Imamoto A., Nagano N., Urakami T., Matsuo K., Tanahashi Y., Azuma H., Koga M.

    J. Clin. Lab. Anal   2016.11

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    DOI: 10.1002/jcla.21985

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  • 学童期発症バセドウ病9例の臨床経過に関する検討 Reviewed

    竹口 諒, 坪田 朋佳, 堀井 百祐, 中村 英記, 真鍋 博美, 平野 至規, 鈴木 滋, 棚橋 祐典, 室野 晃一

    名寄市立病院医誌   2016.10

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  • Serial sonographic findings during progression from acute pyelonephritis to renal abscess: a rare case report Reviewed

    Masayuki Sato, Shigeru Suzuki, Sorachi Shimada, Shiho Yamamoto, Genya Taketazu, Tokuo Mukai, Mio Taketazu, Hiroshi Sakata, Junichi Oki

    CEN Case Rep   2016.9

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  • High prevalence of DUOX2 mutations in Japanese patients with permanent congenital hypothyroidism or transient hypothyroidism Reviewed

    Matsuo K., Tanahashi Y., Mukai T., Suzuki S., Tajima T., Azuma H., Fujieda K.

    J Pediatr Endocrinol Metab   2016.7

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    DOI: 10.1515/jpem-2015-0400

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  • 胎児ヘモグロビン(HbF)高値例のHbA1cは低値乖離する 高HbF血症2例を用いた解析 Reviewed

    古賀正史, 稲田慎也, 鈴木 滋, 細江重郎, 山本恒彦

    Diabetes Frontier   2016.4

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  • Structural Analysis on the Pathologic Mutant Glucocorticoid Receptor Ligand-Binding Domains Reviewed

    Hurt DE, Suzuki S., Mayama T., Charmandari E., Kino T.

    Mol Endocrinol   2016.2

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    DOI: 10.1210/me.2015-1177

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  • CRTC2 Is a Coactivator of GR and Couples GR and CREB in the Regulation of Hepatic Gluconeogenesis Reviewed

    Hill MJ, Suzuki S., Segars JH, Kino T.

    Mol Endocrinol   2016.1

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    DOI: 10.1210/me.2015-1237

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  • Age-adjusted glycated albumin accurately reflects blood glucose in patients with neonatal diabetes mellitus: comparison with calculated glycated albumin determined by past blood glucose concentrations Reviewed

    Suzuki S., Furuya A., Oshima M., Amamiya S., Nakao A., Wada K., Okuhara K., Hayano S., Imamoto A., Matsuo K., Tanahashi Y., Azuma H., Koga M.

    Ann Clin Biochem   2016.1

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    DOI: 10.1177/0004563215589382

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  • A case of pancreatic agenesis and congenital heart defects with a novel GATA6 nonsense mutation: Evidence of haploinsufficiency due to nonsense-mediated mRNA decay

    Suzuki, S., Nakao, A.b, Sarha, A.R.a c, Furuya, A.a, Matsuo, K.a, Tanahashi, Y.a, Kajino, H.a, Azuma, H.a

    Am. J. Med. Genet. Part A   164 ( 2 )   476 - 479   2014

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    Recently, GATA6 heterozygous loss-of-function mutations were reported to cause pancreatic agenesis and congenital heart defects (PACHD [OMIM:600001]). However, the molecular mechanisms resulting from premature termination codons have not been examined in this disorder. The objective of this study was to perform a genetic analysis of a patient with PACHD. A female patient presented with ventricular septal defect, patent ductus arteriosus, and congenital diaphragmatic hernia at birth. Permanent neonatal diabetes mellitus and pancreatic exocrine deficiency due to pancreatic agenesis was diagnosed at 1 month of age. PCR-direct sequencing of GATA6 revealed that the patient is heterozygous for a novel de novo nonsense mutation of c.1477C>T, p. Arg493X in exon 5. RT-PCR direct sequencing of the RT-PCR products of total RNA from peripheral blood of the patient for the region encompassing exons 4-6 revealed only the wild-type allele. This finding provides the evidence for the occurrence of nonsense-mediated mRNA decay (NMD) in the p.Arg493X mutation. Quantitative RT-PCR analysis revealed that the expression of GATA6 transcript in the patient was less than half compared with normal control samples. This is the first evidence that GATA6 haploinsufficiency is caused by NMD in vivo, and we conclude that GATA6 haploinsufficiency causes not only PACHD but may affect other organs derived from the endoderm. Further screenings of GATA6 mutations in patients with various forms of diabetes and/or congenital heart disease with other visceral malformation may reveal the impact of GATA6 mutations on diabetes and congenital malformation. © 2013 Wiley Periodicals, Inc.

    DOI: 10.1002/ajmg.a.36275

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  • Age-adjusted glycated albumin: A more robust parameter to establish glycaemic control in neonatal diabetes mellitus

    Suzuki, S., Koga, M., Niizeki, N.c, Furuya, A.a, Matsuo, K.a, Tanahashi, Y.a, Azuma, H.a

    Ann. Clin. Biochem.   51 ( 5 )   602 - 605   2014

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    Background: We previously reported that glycated albumin (GA) levels increased in an age-dependent manner in infancy. In order to determine whether this phenomenon is true from infancy to adulthood, we investigated the GA levels in non-diabetic subjects of a wide range of age. Methods: GA levels of 376 non-diabetic subjects [average age, 31.8±23.8 years (4 days-78 years)] were determined. A relationship between GA and logarithmically transformed age [log(age)] was analysed. Results: GA levels were significantly positively correlated with log(age) [R=0.865, P<0.0001, GA=1.77×log(day)+6.55]. Based on a regression line, we established the formula for adjusting GA levels according to age. Conclusion: We showed that GA increases with age from infancy to adulthood and that normal GA levels are demonstrated as a simple regression formula with log(age). This formula allowing us to use the adult reference range has the potential for treatment monitoring of diabetic patients regardless of age. © The Author(s) 2013 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

    DOI: 10.1177/0004563213512617

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  • Glycemic control and motor development in a patient with intermediate DEND

    Oka, H., Suzuki, S.a, Furuya, A.a, Matsuo, K.a, Amamiya, S.b, Oshima, M., Oka, T.b, Mukai, T.a c, Okayama, A.a, Araki, A.a, Azuma, H.a, Tanahashi, Y.a

    Pediatr. Int.   56 ( 3 )   432 - 435   2014

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    The most common cause of neonatal diabetes, KCNJ11 gene mutation, can manifest as a neurological disorder. The most severe form consists of a constellation of developmental delay, epilepsy, and neonatal diabetes (DEND). Intermediate DEND (iDEND) refers to a milder presentation without epilepsy. We present a child with iDEND, for whom insulin injections were replaced with glibenclamide therapy at 17 months of age because of poor glycemic control and delayed motor development. Three months after initiation of glibenclamide, HbA1c decreased from 10.2% to 5.6%. Continuous glucose monitoring indicated that blood glucose fluctuations were suppressed while on glibenclamide. Furthermore, after initiating glibenclamide therapy, the developmental quotient (DQ) for motor ability markedly improved from 60 to 91, whereas the DQ for language and adoptive ability remained as they had been before the sulfonylurea treatment. Sulfonylurea treatment improved glycemic control and motor development in the present patient. © 2014 Japan Pediatric Society.

    DOI: 10.1111/ped.12294

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  • HbA1c can be a useful glycemic control marker for patients with neonatal diabetes mellitus older than 20weeks of age

    Furuya, A., Suzuki, S.a, Koga, M., Oshima, M.c, Amamiya, S.c i, Nakao, A., Wada, K.e, Okuhara, K.g, Hayano, S.h, Matsuo, K.a, Tanahashi, Y.a, Azuma, H.a

    Clin. Chim. Acta   436   93 - 96   2014

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    Background: The accuracy of most HbA1c analysis methods is affected by the presence of increased fetal hemoglobin (HbF). The objective of this study was to investigate the age at which HbA1c measurements become useful for monitoring glycemic control in patients with neonatal diabetes mellitus (NDM). Methods: We retrospectively analyzed the data of 5 NDM patients diagnosed at 38 ± 20 days of age, who each had several available HbA1c measurements during the first year of life, with a control group of HbA1c values over the course of 1 year for 13 patients with type 1 diabetes mellitus (T1DM). Mean blood glucose (MBG) levels derived from premeal or premeal plus bedtime blood glucose measurements prior to HbA1c measurements were compared to HbA1c values. Results: The NDM patients' age at which the difference in the HbA1c/MBG ratios became not significant between the NDM patients and the T1DM patients was 21. weeks of age and over. Even after the HbA1c was adjusted for HbF, this ratio was significantly lower in the NDM patients at < 21 weeks of age than in the T1DM patients. Conclusions: HbA1c can be a useful glycemic control marker for NDM patients >. 20. weeks of age. © 2014 Elsevier B.V.

    DOI: 10.1016/j.cca.2014.05.005

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  • Prognosis of primary aldosteronism in japan: Results from a nationwide epidemiological study

    Miyake, Y.a, Tanaka, K.a, Nishikawa, T., Naruse, M.c, Takayanagi, R., Sasano, H.e, Takeda, Y.f, Shibata, H.g, Sone, M.h, Satoh, F.i, Yamada, M.j, Ueshiba, H.k, Katabami, T., l, Iwasaki, Y., Tanaka, H.n, Tanahashi, Y.o, Suzuki, S.o, Hasegawa, T., Katsumata, N., Tajima, T., Yanase, T.

    Endocr. J.   61 ( 1 )   35 - 40   2014

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    The Research Committee of Disorders of Adrenal Hormones, Japan, undertook a nationwide epidemiological study of primary aldosteronism (PA). The present study was undertaken as a part of this study to reveal the relationship between type of treatment and the prognosis of PA. In the primary survey, 4161 patients with PA during the period January 1, 2003-December 31, 2007 were reported from 3252 departments of internal medicine, pediatrics and urology. In the secondary survey, a questionnaire that requested detailed clinical information on individual patients was sent to those departments reporting patients in the primary survey. In total, data on 1706 patients with PA were available in the present study. Among patients with bilateral or unilateral aldosterone-producing adenoma, after adjustment for age at which prognosis was examined, sex, surgical treatment and medical treatment, surgical treatment was significantly associated with amelioration of hypertension (adjusted odds ratio [OR]: 0.47 [95% confidence interval (CI): 0.29-0.77]) and hypokalemia (adjusted OR: 0.17 [95% CI: 0.11-0.29]). No significant relationship was observed between medical treatment and such prognosis in this group of patients. Among patients with bilateral or unilateral adrenal hyperplasia, surgical, but not medical, treatment was significantly associated with amelioration of hypokalemia (adjusted OR: 0.23 [95% CI: 0.06-0.74]), while there was no relationship between surgical or medical treatment and the prognosis of hypertension. In conclusion, surgery offered a better prognosis of PA than medication with regards to hypertension and hypokalemia, with the limitation that a new anti-aldosterone drug, eplerenone, was not available during the study period. © The Japan Endocrine Society.

    DOI: 10.1507/endocrj.EJ13-0353

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  • 【小児内分泌学の進歩2014】 性腺・副腎 KAL1遺伝子欠失を示したKallmann症候群のMLPA法による家族内遺伝子解析、ホルモンと臨床、2013;61:981-985.

    棚橋 祐典, 鈴木 滋, 松尾 公美浩, 古谷 曜子, 向井 徳男, 東 寛

    ホルモンと臨床   2013.12

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  • Efficacy and safety of long-term, continuous subcutaneous octreotide infusion for patients with different subtypes of KATP-channel hyperinsulinism

    Yorifuji, T.a, Kawakita, R.a, Hosokawa, Y.a, Fujimaru, R.a, Matsubara, K., Aizu, K.c, Suzuki, S., Nagasaka, H.e, Nishibori, H.f, Masue, M.

    Clin. Endocrinol.   78 ( 6 )   891 - 897   2013

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    Objective To evaluate the efficacy of long-term, continuous, subcutaneous octreotide infusion for congenital hyperinsulinism caused by mutations in the KATP-channel genes, KCNJ11 and ABCC8. Patients Fifteen Japanese patients with diazoxide-unresponsive, KATP-channel hyperinsulinism. Methods Molecular diagnoses were made by sequencing and multiple ligation-dependent probe amplification analysis. In patients with paternally inherited, monoallelic mutations, 18F-DOPA PET scans were performed to determine the location of the lesion. The patients were treated with continuous, subcutaneous octreotide infusion at a dosage of up to 25 μg/kg/day, using an insulin pump to maintain blood glucose levels higher than 3·33 mmol/l. Additional treatments (IV glucose, glucagon or enteral feeding) were administered as needed. The efficacy of the treatment was assessed in patients who received octreotide for 4 months to 5·9 years. Results Three patients had biallelic mutations, and 12 had monoallelic, paternally inherited mutations. Four patients with monoallelic mutations showed diffuse 18F-DOPA uptake, whereas seven patients showed focal uptake. Octreotide was effective in all the patients. The patients with biallelic mutations required a higher dosage (17-25 μg/kg/day), and two patients required additional treatments. By contrast, the patients with monoallelic mutations required a lower dosage (0·5-21 μg/kg/day) irrespective of the PET results and mostly without additional treatments. Treatment was discontinued in three patients at 2·5, 3·3 and 5·9 years of age, without psychomotor delay. Except for growth deceleration at a higher dosage, no significant adverse effects were noted. Conclusions Long-term, continuous, subcutaneous octreotide infusion is a feasible alternative to surgery especially for patients with monoallelic KATP-channel mutations. © 2012 John Wiley &amp; Sons Ltd.

    DOI: 10.1111/cen.12075

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  • Glycated albumin is lower in infants than in adults and correlated with both age and serum albumin

    Suzuki, S., Koga, M., Niizeki, N.c, Furuya, A.a, Takahashi, H.a, Matsuo, K.a, Tanahashi, Y.a, Kawata, Y.a, Asai, H.a, Tsuchida, E.a, Nohara, F.a, Okamoto, T.a, Nagaya, K.a, Azuma, H.a

    Pediatr. Diabetes   14 ( 1 )   25 - 30   2013

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    Background: Glycated albumin (GA) reflects glycemic control in patients with neonatal diabetes mellitus (NDM). However, GA in NDM patients is apparently low in relation to glycemia. Objective: To establish the reference intervals for GA in healthy infants. Subjects and Methods: Fifty-eight healthy, full-term newborn infants were used to define the GA reference values and to investigate its relationship to plasma glucose (PG) and serum albumin. The infants were categorized into three groups according to age: group A, 5 (4-6) median (range) d: n=18; group B, 33 (30-38) d: n=19; and group C, 181 (50-352) d: n=21. We also studied 212 non-diabetic adults [group D, 53 (28-78) yr old] and the 5 NDM patients previously reported for GA comparisons. Results: In the infants, GA was strongly positively correlated with logarithmic transformation of age [log (age)] (p = 0.831, p < 0.0001). The GA in groups A, B, C, and D were 7.3±1.0%, 8.6±1.1%, 10.9±0.8%, and 14.0±1.1%, respectively. The GA was more strongly positively correlated with serum albumin (r=0.768, p < 0.0001) than with PG (r=0.596, p < 0.0001). When GA levels were compared with the age-dependent reference values, GA in the transient NDM patient was normalized although GA in the four permanent NDM patients decreased but remained high after insulin therapy. Conclusions: This study showed that the reference range for GA in infants is lower than that of adults and increases with age, with which we confirmed that GA in the NDM patients reflected the clinical course. Consequently, GA in NDM patients should be compared with the age-based reference values to assess the accurate glycemic status. © 2012 John Wiley & Sons A/S.

    DOI: 10.1111/j.1399-5448.2012.00895.x

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  • A case of vitamin D deficiency without elevation of serum alkaline phosphatase in a carrier of hypophosphatasia

    Matsuo, K., Mukai, T., Furuya, A.a, Suzuki, S.a, Tanahashi, Y.a, Azuma, H.a

    Clin. Pediatr. Endocrinol.   22 ( 4 )   73 - 76   2013

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    Elevated serum alkaline phosphatase (ALP) is a screening marker for the diagnosis of vitamin D deficiency, which may fail to be diagnosed if serum ALP is not elevated. Here, we describe a case of vitamin D deficiency without elevation of serum ALP. A 1-year-old Japanese girl was referred to our hospital for the evaluation of genu varum. Her serum intact PTH level was elevated, while her serum ALP level was normal. Furthermore, her serum 25-hydroxyvitamin D level was reduced, and her urine phosphoethanolamine (PEA) level was mildly elevated. ALPL gene analysis revealed she was a heterozygous carrier of hypophosphatasia (c.1559delT). Serum intact PTH and urine PEA evaluations were helpful for diagnosing vitamin D deficiency and hypophosphatasia carrier status, respectively. Therefore, the possibility of vitamin D deficiency without elevation of serum ALP should be considered. © 2013 by The Japanese Society for Pediatric Endocrinology.

    DOI: 10.1297/cpe.22.73

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  • Calculation of HbA1c and glycated albumin from serially measured self-Monitored blood glucose in patients with type 1 diabetes mellitus

    Koga, M.a, Suzuki, S., Matsuo, K., Tanahashi, Y., Azuma, H.b, Kasayama, S.

    Clin. Chim. Acta   425   188 - 191   2013

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    Background: Both HbA1c and glycated albumin (GA) values are influenced by weighted mean of preceding blood glucose levels depending on each half-life. Based on this principle, we developed formulas for calculation of HbA1c and GA using data from self-monitored blood glucose (SMBG). We also calculated HbA1c and GA in diabetic patients using the developed formulas. Methods: This study included 9 patients with childhood-onset type 1 diabetes mellitus (6 males and 3 females; aged 11.4. ±. 4.2. y). From the weekly mean blood glucose (MBG) values obtained by the SMBG data during the previous 20. weeks, we calculated HbA1c and GA using the developed formulas and compared the calculated values with the measured values (n. =. 42). Results: The measured and the calculated values of HbA1c were 8.5. ±. 0.9% and 8.3. ±. 1.2%, respectively. The measured and the calculated values of GA were 24.9. ±. 3.7% and 26.4. ±. 4.0%, respectively. There were strong positive correlations between both values of HbA1c and GA (P. <. 0.0001). Conclusions: The calculated HbA1c and GA values using the developed formulas from the SMBG data were generally in agreement with the measured values. Using the calculation formulas, the values of HbA1c and GA could be estimated from serially measured SMBG data. © 2013 Elsevier B.V.

    DOI: 10.1016/j.cca.2013.07.029

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  • Evaluation of glycated hemoglobin and fetal hemoglobin-adjusted HbA1c measurements in infants

    Suzuki, S., Koga, M., Niizeki, N.c, Furuya, A.a, Matsuo, K.a, Tanahashi, Y.a, Tsuchida, E.a, Nohara, F.a, Okamoto, T.a, Nagaya, K.a, Azuma, H.a

    Pediatr. Diabetes   14 ( 4 )   267 - 272   2013

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    Background: As the presence of fetal hemoglobin (HbF) affects the accuracy of hemoglobin A1c (HbA1c) analysis methods, HbA1c measurement may not be a good indicator for patients with neonatal diabetes mellitus, whereas glycated albumin (GA) may be a good indicator. Objective: To investigate whether total glycated hemoglobin (GHb) or HbF-adjusted HbA1c (adj-HbA1c) can act as a glycemic control marker in infants. Subjects and Methods: Plasma glucose (PG), GA, HbF, GHb measured using the affinity method, and HbA1c measured using the latex-immunoturbidimetry (LA) or the high-performance liquid chromatography (HPLC) methods were determined in 26 full-term newborn infants aged 4-234d. Adj-HbA1c was calculated as HbA1c/(total Hb - HbF). Results: GHb, adj-HbA1c measured using the LA and the HPLC methods were 4.8±0.5%, 4.5±0.5%, and 4.7±0.6%, respectively. GA was most positively correlated with PG (r=0.696, p<0.0001). GHb was positively correlated with both PG (r=0.479, p=0.013) and GA (r=0.727, p<0.0001). Adj-HbA1c measured using the LA method was positively correlated with GA (r=0.465, p=0.017), but not PG (r=0.304, p=0.132). Adj-HbA1c measured using the HPLC method was correlated with neither PG (r=-0.077, p=0.710) nor GA (r=0.360, p=0.071). Conclusions: GHb measured using the affinity method may be a useful glycemic control marker in infants. Although adj-HbA1c measured using the LA method was correlated with GA, it may not be a practical measure because it was not correlated with PG and determining HbF levels using HPLC method can be troublesome. Adj-HbA1c measured using the HPLC method should not be used as a glycemic marker in infants. © 2013 John Wiley & Sons A/S.

    DOI: 10.1111/pedi.12013

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  • 【小児内分泌学の進歩2013】 糖尿病・糖代謝・カルシウム代謝 KATPチャネル性先天性高インスリン血症のオクトレオチド持続皮下注療法

    依藤 亨, 川北 理恵, 細川 悠紀, 藤丸 季可, 増江 道哉, 西堀 弘記, 松原 康策, 会津 克哉, 鈴木 滋

    ホルモンと臨床   2012.12

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  • Glycated albumin in patients with neonatal diabetes mellitus is apparently low in relation to glycemia compared with that in patients with type 1 diabetes mellitus Reviewed

    Suzuki S., Koga M., Takahashi H., Matsuo K., Tanahashi Y., Azuma H.

    Hormone Research in Paediatrics   77 ( 5 )   273 - 276   2012.4

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    DOI: 10.1159/000337914

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  • 膜性増殖性糸球体腎炎の治療中、尿中遊離コルチゾール測定によりステロイド薬の吸収を評価し得た短腸症候群の1例 Reviewed

    高橋弘典, 鈴木滋, 松尾公美浩, 棚橋祐典, 佐々木聡

    日本小児腎臓病学会雑誌   2011.11

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  • Axial Spondylometaphyseal Dysplasia:Additional Reports Reviewed

    Suzuki S., Kim OH, Makita Y., Saito T., Lim GY, Cho TJ, Al-Swaid A., Alrasheed S., Sadoon E., Miyazaki O., Nishina S., Superti-Furga A., Unger S., Fujieda K., Ikegawa S., Nishimura G.

    Am J Med Genet Part A   2011.10

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  • Glycated albumin but not HbA1c reflects glycaemic control in patients with neonatal diabetes mellitus Reviewed

    Suzuki S., Koga M., Amamiya S., Nakao A., Wada K., Okuhara K., Hanano S., Sarhat AR, Takahashi H., Matsuo K., Tanahashi Y., Fujieda K.

    Diabetologia   2011.9

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  • 脳室内出血・出血後水頭症を合併した先天性ネフローゼ症候群の1例 Reviewed

    高橋弘典, 青山藍子, 浅井洋子, 鈴木滋, 松尾公美浩, 棚橋祐典, 野原史勝, 岡本年男, 長屋建, 林時仲, 柿崎秀宏, 中西浩一, 佐々木聡, 森田研, 野々村克也

    日本小児腎不全学会雑誌   2011.7

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  • 胃腸炎を契機に臍ヘルニア嵌頓をきたした一例 Reviewed

    小林瑞, 五十嵐加弥乃, 田中亮介, 二井光麿, 梶濱あや, 鈴木滋, 土田悦司, 竹田津原野, 佐藤敬, 梶野真弓, 高瀬雅史, 白井勝, 坂田宏, 沖潤一, 高橋昌宏, 中野詩朗, 宮城久之, 米谷理沙, 皆川知広, 塩谷隆太

    旭川厚生病院医誌   2011.6

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  • Measurement of glycated hemoglobin and glycated albumin in umbilical cord: evaluation of the glycemic control indicators in neonates Reviewed

    Koga M., Murai J., Saito H., Yamada Y., Mori T., Suno S., Takeuchi K., Suzuki S., Fujieda K., Kasayama S.

    Journal of Perinatology   2011.6

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    DOI: 10.1038/jp.2010.144

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  • 【小児内分泌学の進歩2011】 副腎 「副腎ホルモン産生異常症実態把握のための全国疫学調査」の中間報告 Invited

    向井徳男, 鈴木滋, 棚橋祐典, 梶野浩樹, 藤枝憲二

    ホルモンと臨床   2011.3

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  • ノロウイルス(G2)感染に伴う急性脳症により一過性の局所性脳浮腫を呈した1例 Reviewed

    五十嵐加弥乃, 田中亮介, 二井光麿, 梶濱あや, 鈴木滋, 土田悦司, 佐藤敬, 竹田津原野, 梶野真弓, 高瀬雅史, 白井勝, 坂田宏, 沖潤一

    小児科臨床   2011.2

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  • ABCC8遺伝子異常を認め新生児一過性糖尿病と診断した超低出生体重児の1例 Reviewed

    大関一裕, 池野充, 清水俊明, 鈴木滋, 蒔田芳男, 藤枝憲二

    日本未熟児新生児学会雑誌   2011.2

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  • 【小児内分泌学の進歩2010】 基礎研究(遺伝子関連) 日本人新生児永続性糖尿病および小児期発症インスリン依存性糖尿病患者におけるインスリン遺伝子解析 Invited

    鈴木滋, 鏡雅代, 堀内勝行, 山藤陽子, 坪内肯二, ミレグリ・マイマイティ, 松尾公美浩, 棚橋裕典, 向井徳男, 藤枝憲二

    ホルモンと臨床   2010.12

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  • Partial paternal uniparental disomy of chromosome 6 in monozygotic twins with transient neonatal diabetes mellitus and macroglossia Reviewed

    Suzuki S., Fujisawa D., Hashimoto K., Asano T., Maimaiti M., Matsuo K., Tanahashi Y., Mukai T., Fujieda K.

    Clinical Genetics   2010.12

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    DOI: 10.1111/j.1399-0004.2010.01433.x

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  • 当院における乳児・小児一次救急蘇生講習会と院内二次救急蘇生講習会の取り組み Reviewed

    梶野真弓, 石羽澤映美, 梶濱あや, 五十嵐加弥乃, 土田悦司, 鈴木滋, 佐藤敬, 竹田津原野, 高瀬雅史, 白井勝, 坂田宏, 沖潤一

    日本小児救急医学会雑誌   2010.10

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  • 亜鉛過量投与の超低出生体重児の1例 Reviewed

    白井勝, 田中亮介, 二井光麿, 梶濱あや, 五十嵐加弥乃, 鈴木滋, 土田悦司, 竹田津原野, 佐藤敬, 梶野真弓, 高瀬雅史, 坂田宏, 沖潤一

    旭川厚生病院医誌   2009.12

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  • Prevalence and risk factors of vitamin D deficiency rickets in Hokkaido, Japan Reviewed

    Matsuo K., Mukai T., Suzuki S., Fujieda K.

    Pediatric International   2009.8

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    DOI: 10.1111/j.1442-200X.2009.02834.x

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  • McCune-Albright症候群患児における末梢血検体を用いた遺伝子診断法についての検討

    向井徳男, 松尾公美浩, 鈴木滋, ミレグリ・マイマイティ

    成長科学協会研究年報   2009.8

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  • 低身長児におけるNPR-B遺伝子異常に関する研究

    向井徳男, 松尾公美浩, 鈴木滋, 上田修

    成長科学協会研究年報   2008.8

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  • Molecular Basis of Neonatal Diabetes in Japanese Patients Reviewed

    Suzuki S., Makita Y., Mukai T., Matsuo K., Ueda O., Fujieda K.

    The Journal of Clinical Endocrinology and Metabolism   2007.10

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    DOI: 10.1210/jc.2007-0486

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  • 成長ホルモン受容体遺伝子エクソン3多型と、出生時身長・体重および臍帯血中インスリン様成長因子濃度との関連性に関する研究

    向井徳男, ミレグリ・マイマイティ, 鈴木滋, 松尾公美浩, 上田修, 蒔田芳男

    成長科学協会研究年報   2007.8

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  • 成長障害患者における生物学的不活性型成長ホルモン発見スクリーニング

    向井徳男, 鈴木滋, 松尾公美浩, 上田修

    成長科学協会研究年報   2006.8

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  • GH-1遺伝子変異を認めた生物学的不活性型成長ホルモンの機能解析

    松尾公美浩, 鈴木滋, 向井徳男

    成長科学協会研究年報   2005.8

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  • Permanent Neonatal Diabetes Mellitus with Growth Disturbance, Developmental Delay, Epilepsy and Dysmorphic Features Reviewed

    Suzuki S., Mukai T., Uetake K., Sageshima S., Matsuo K., Ueda O., Ito Y., Fujieda K.

    Clinical Pediatric Endocrinology   2005.4

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    DOI: 10.1297/cpe.14.S24_81

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  • 1988年から2002年における北海道上川支庁の小児細菌性髄膜炎の疫学的調査 Reviewed

    坂田宏, 白井勝, 梶野真弓, 高瀬雅史, 岡本年男, 三浦菜生, 長森恒久, 鈴木滋

    日本小児科学会雑誌   2004.3

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  • 当院NICUにおける医学生卒前実習の感想のまとめ Reviewed

    白井勝, 鈴木滋, 長森恒久, 三浦菜生, 岡本年男, 高瀬雅史, 梶野真弓, 坂田宏, 丸山静男

    旭川厚生病院医誌   2003.6

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  • 小児呼吸器感染症患者におけるpenicillin耐性Streptococcus pneumoniaeとampicillin耐性Haemophilus influenzaeの頻度 Reviewed

    坂田宏, 白井勝, 梶野真弓, 佐藤敬, 中村英記, 三浦菜生, 長森恒久, 鈴木滋, 志賀誠, 菊地祐美子

    旭川厚生病院医誌   2002.12

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  • 先天性水頭症の脳室穿刺治療における髄液中サイトカインの変動 Reviewed

    白井勝, 鈴木滋, 長森恒久, 三浦菜生, 中村英記, 佐藤敬, 梶野真弓, 坂田宏, 丸山静男

    旭川厚生病院医誌   2002.12

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  • 旭川厚生病院NICUにおける出生体重750g未満の児の神経学的長期予後 Reviewed

    白井勝, 鈴木滋, 長森恒久, 三浦菜生, 中村英記, 佐藤敬, 梶野真弓, 坂田宏, 丸山静男, 荒木章子, 沖潤一, 宮本晶恵

    臨床小児医学   2002.8

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Books

  • 病気が見える vol 15 小児科

    鈴木 滋( Role: Supervisor (editorial))

    医療情報科学研究所  2022.10 

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  • 小児内分泌疾患の治療(日本小児内分泌学会[編])

    鈴木 滋( Role: Sole author高身長)

    診断と治療社  2022.8 

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  • 小児内分泌疾患の治療(日本小児内分泌学会[編])

    鈴木 滋( Role: Sole author高身長)

    診断と治療社  2022.8 

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  • 小児内分泌学改訂第3版(日本小児内分泌学会[編])

    鈴木 滋( Role: Sole author高身長と過成長)

    診断と治療社  2022.2 

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  • カラー版糖尿病学、門脇孝、石橋俊、佐倉宏、戸邉一之、野田光彦編

    鈴木滋, 蒔田芳男, 藤枝憲二

    西村書店  2007 

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MISC

  • 小児の治療指針, 2型糖尿病/遺伝性糖尿病

    鈴木 滋

    小児科診療   2023.4

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  • 小児の治療指針, 2型糖尿病/遺伝性糖尿病

    鈴木滋

    小児科診療   2023.4

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  • 【小児疾患診療のための病態生理2 改訂第6版】内分泌疾患 Addison病

    鈴木 滋

    小児内科53巻増刊   2022.1

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  • 【小児疾患診療のための病態生理】 代謝栄養性疾患 新生児糖尿病

    鈴木滋

    小児内科   2020.11

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  • ステロイドサルファターゼ欠損症

    鈴木滋

    別冊日本臨牀領域別症候群シリーズNo.4   2019.3

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  • 11β-ヒドロキシラーゼ欠損症

    鈴木滋

    別冊日本臨牀領域別症候群シリーズNo.2   2018.11

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  • 【小児疾患診療のための病態生理2 改訂第5版】 内分泌疾患 Addison病

    鈴木滋

    小児内科   2015.11

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  • Glycemic control indicators in patients with neonatal diabetes mellitus

    Suzuki S., Koga M.

    World J Diabetes   2014.4

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  • 原発性グルココルチコイド抵抗症

    木野 智重, 間山 貴文, 鈴木 滋

    ホルモンと臨床   2012.3

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  • 【必携 小児の薬の使い方】 疾患に対する薬剤の選び方・使い方と注意 内分泌・代謝疾患 急性副腎不全

    鈴木滋, 藤枝憲二

    小児内科   2010.10

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  • 【最近話題の遺伝子異常による内分泌および類縁疾患】 新生児糖尿病

    鈴木滋, 藤枝憲二

    ホルモンと臨床   2010.7

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  • 【小児疾患診療のための病態生理】 代謝栄養性疾患 新生児糖尿病

    鈴木滋, 蒔田芳男, 藤枝憲二

    小児内科   2009.8

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  • 難治疾患 未解明の研究課題と治療への挑戦 新生児糖尿病 明らかになってきた分子基盤が病態解明と治療応用に与えるインパクト

    鈴木滋, 藤枝憲二

    実験医学   2009.8

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  • 【新時代の糖尿病学 病因・診断・治療研究の進歩】 糖尿病基礎研究の進歩 糖尿病と耐糖能低下の成因分類と発症機序 他の疾患や病態に起因する糖尿病 インスリン抵抗性・耐糖能異常を伴う遺伝性症候群 Down症候群(解説/特集)

    鈴木滋, 藤枝憲二

    日本臨床   2008.5

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  • 【小児・思春期糖尿病】 新生児糖尿病

    蒔田芳男, 鈴木滋, 藤枝憲二

    Diabetes Frontier   2006.10

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  • 【内分泌症候群(第2版) その他の内分泌疾患を含めて】 性機能低下を伴う遺伝性(先天性)症候群 ステロイドサルファターゼ欠損症

    鈴木滋, 藤枝憲二

    日本臨床   2006.9

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  • 【新生児内分泌疾患の診断とその治療】 新生児一過性糖尿病

    鈴木滋, 蒔田芳男, 藤枝憲二

    周産期医学   2005.12

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  • 【血糖調節from A to Z】 新生児期糖尿病

    鈴木滋, 蒔田芳男

    小児科診療   2005.10

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▼display all

Presentations

  • Paternally derived chromosome 6q24 triplication causes neonatal diabetes mellitus International conference

    Shigeru Suzuki, Kanayo Ochiai, Yuichi Nishikado

    11th International Meeting of Pediatric Endocrinology - IMPE2023 

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    Event date: 2023.3

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  • 新生児バセドウ病の治癒後に中枢性甲状腺機能低下症が顕性化した1例

    中村英記, 石若久海子, 栗澤未央ジューン, 泉健吾, 仙波はるか, 堀井百祐, 平野至規, 室野晃一, 鈴木滋

    日本小児科学会北海道地方会第316回例会 

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    Event date: 2023.2

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  • 刺激型の抗TSH受容体抗体(TSAb)が陽性であるDown症候群に合併した橋本病の2例

    柴垣有希, 鈴木 滋, 國米崇秀, 古谷曜子, 高橋悟

    第1回日本小児内分泌学会北海道地方会 

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    Event date: 2023.1

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  • 新生児マススクリーニング(NBS)結果判明時に著明な電解質異常を認めた21水酸化酵素欠損症(21OHD)の女児例

    國米崇秀, 山村日向子, 古谷曜子, 鈴木滋, 高橋悟

    日本小児科学会北海道地方会第315回例会 

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    Event date: 2022.12

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  • 北海道における小児糖尿病児の長期予後調査-特に死亡例についての解析-

    松浦信夫, 横道洋司, 伊藤 善也, 鈴木 滋, 望月恵美, 母坪智行, 北海道内, 歳未満発症, 型糖尿病児の長期予後に関する研究班

    第 55 回日本小児内分泌学会学術集会 

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    Event date: 2022.11

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • 多様な表現型を呈した乳幼児期発症慢性甲状腺炎の3例

    柴垣有希, 鈴木滋, 棚橋祐典, 中村英記, 平野至規, 田中聰, 髙瀨雅史

    第 55 回日本小児内分泌学会学術集会 

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    Event date: 2022.11

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  • 先天性腎性尿崩症を疑うが, 多尿の程度は軽度でAVPR2およびAQP2に病的変異を認めない3歳女児例

    齊藤翔真, 國米崇秀, 古谷曜子, 竹田津原野, 鈴木滋, 高橋悟

    第 55 回日本小児内分泌学会学術集会 

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    Event date: 2022.11

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  • SU薬の追加治療としてSGLT2阻害薬が有効であったHNF4A-MODYの一例

    鈴木 滋, 國米 崇秀, 古谷 曜子, 髙橋 悟

    第 55 回日本小児内分泌学会学術集会 

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    Event date: 2022.11

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  • 新生児糖尿病の理解を深める

    鈴木滋

    第 55 回日本小児内分泌学会学術集会 

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    Event date: 2022.11

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

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  • 副腎クリーゼの罹患率と危険因子~多施設共同前向き観察研究による real world evidence~

    細川真弓, 市橋洋輔, 長崎啓祐, 長谷川行洋, 濱島崇, 永松扶紗, 鈴木滋, 沼倉周彦, 天野 直子, 佐々木悟郎, 西垣五月, 永原敬子, 曽根田瞬, 有安大典, 井原健二, 鎌崎穂高, 麻生敬子, 長谷川奉延, 石井智弘

    第 55 回日本小児内分泌学会学術集会 

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    Event date: 2022.11

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  • 小児バセドウ病を対象とした抗甲状腺剤単独療法とコレステロール吸収阻害剤併用療法のランダム化比較試験

    長崎啓祐, 高桑聖, 八ツ賀秀一, 鈴木滋, 岡田賢, 田久保憲行, 澤田浩武, 長谷川行洋

    第 55 回日本小児内分泌学会学術集会 

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    Event date: 2022.11

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  • 道内発症小児糖尿病児の長期予後調査を終えてー調査で何が分かったかー

    松浦信夫, 横道洋司, 伊藤 善也, 鈴木 滋, 望月恵美, 母坪智行, 北海道内, 歳未満発症, 型糖尿病児の長期予後に関する研究班

    日本糖尿病学会 第56回北海道地方会 

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    Event date: 2022.10

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  • Neonatal Diabetes: Etiology, Diagnosis and Management International conference

    Shigeru Suzuki

    The 12th Biennial Scientific Meeting of the Asia Pacific Paediatric Endocrine Society 2022 

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    Event date: 2022.10

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

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  • インスリン療法で軽快した糖尿病性ケトアシドーシスに合併した著明な高中性脂肪血症の1例

    國米 崇秀, 山村 日向子, 鈴木 滋

    第27回日本小児・思春期糖尿病学会年次学術集会 

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    Event date: 2022.7

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  • サンドイッチELISA法による小児グルカゴンの基準値と肥満の影響の検討

    鈴木 滋, 森 千夏, 山村 日向子, 國米 崇秀, 棚橋 祐典

    第95 回日本内分泌学会学術総会 

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    Event date: 2022.6

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  • グリコアルブミン/ヘモグロビンA1c比は低血糖発症の予測因子として有用である

    望月美恵, 武者育麻, 雨宮伸, 小林浩司, 鈴木滋, 國米崇秀, 菅原大輔, 小山さとみ, 小林基章, 松浦信夫, 菊池透

    第65回日本糖尿病学会年次学術集会 

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    Event date: 2022.5

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  • 1959年から1996年に発症した小児期発症1型糖尿病糖尿病児の長期予後-北海道におけるPopulation-basedの調査研究-

    松浦信夫, 横道洋司, 伊藤 善也, 鈴木 滋, 望月恵美, 母坪智行, 北海道内, 歳未満発症, 型糖尿病児の長期予後に関する研究班

    第65回日本糖尿病学会年次学術集会 

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    Event date: 2022.5

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  • 北海道におけるビタミンD欠乏症の疫学調査

    福井晨介, 三好雄大, 坪田朋佳, 國米崇秀, 鈴木滋, 棚橋祐典

    日本小児科学会北海道地方会第312回例会 

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    Event date: 2021.12

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  • 急性リンパ性白血病による溶骨性高Ca血症に認めた血中FGF23高値

    山村日向子, 鈴木滋, 國米崇秀, 古谷曜子, 棚橋祐典, 櫻井由香里, 鳥海尚久, 更科岳大, 東寛

    第31回臨床内分泌代謝Update 

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    Event date: 2021.11

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  • 小児糖尿病 update(専門医単位更新のための指定講演 1)

    鈴木 滋

    第55回日本糖尿病学会北海道地方会 

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    Event date: 2021.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

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  • 当科における小児糖尿病診療・研究・教育(糖尿病医療者・研究者のダイバーシティをpromoteする委員会企画「糖尿病研修指導医取得後のキャリアを先輩と描く」)

    鈴木 滋

    第55回日本糖尿病学会北海道地方会 

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    Event date: 2021.10

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

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  • 1B型糖尿病経過中の眼科スクリーニングを契機に診断に至ったWolfram症候群の1例

    國米崇秀, 鈴木滋, 山村日向子, 棚橋祐典

    第54回日本小児内分泌学会学術集会 

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    Event date: 2021.10

    Language:Japanese   Presentation type:Poster presentation  

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  • A mutation of the β-domain in POU1F1 causes pituitary deficiency due to dominant PIT-1β expression

    Shigeru Suzuki, Kumihiro Matsuo, Yoshiya Ito, Atsushi Kobayashi, Takahide Kokumai, Akiko Furuya, Osamu Ueda, Tokuo Mukai, Koichi Yano, Kenji Fujieda, Akimasa Okuno, Yusuke Tanahashi, Hiroshi Azuma

    第54回日本小児内分泌学会学術集会 

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    Event date: 2021.10

    Language:English   Presentation type:Oral presentation (general)  

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  • Year Book 6 糖尿病・肥満・低血糖

    鈴木 滋

    第54回日本小児内分泌学会学術集会 

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    Event date: 2021.10

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • 北海道における小児期発症1型糖尿病患者の長期予後

    横道洋司, 望月美恵, 鈴木滋, 伊藤善也, 松浦信夫

    第54回日本小児内分泌学会学術集会 

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    Event date: 2021.10

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • Temple症候群における成長ホルモン治療では、思春期早発症発症も念頭においた治療効果判定が重要である

    山村日向子, 國米崇秀, 鈴木滋, 鏡雅代

    第54回日本小児内分泌学会学術集会 

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    Event date: 2021.10

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • 染色体6q24 triplicationによる新生児糖尿病の一例

    鈴木滋, 落合加奈代, 西門優一, 棚橋祐典, 東寛

    第64回日本糖尿病学会年次学術集会 

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    Event date: 2021.5

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • 甲状腺機能のグリコアルブミン/HbA1c比へ与える影響を評価する

    武者育麻, 望月美恵, 小林浩司, 鈴木滋, 小林基章, 棚橋祐典, 小山さとみ, 菅原大輔, 南谷幹史, 杉原茂孝, 菊池透, 雨宮伸

    第64回日本糖尿病学会年次学術集会 

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    Event date: 2021.5

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • 低身長、急性肝不全、免疫異常、視神経萎縮、てんかん、知的障害および糖尿病を呈するNBAS遺伝子異常症例の長期経過

    鈴木滋, 國米崇秀, 古谷曜子, 長森恒久, 松尾公美浩, 上田修, 向井徳男, 伊藤善也, 矢野公一, 藤枝憲二, 奥野晃正, 棚橋祐典, 東寛

    第124回日本小児科学会学術集会 

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    Event date: 2021.4

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  • 食事内容によりグルカゴン値の顕著な変化が認められた思春期1型糖尿病の1例

    鈴木滋, 國米崇秀, 棚橋祐典, 東寛

    第93回日本内分泌学会学術総会 

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    Event date: 2020.7 - 2020.8

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  • 染色体6q24重複を有する父から、両アリルの6q24が1コピーずつ伝達された新生児一過性糖尿病の一例

    鈴木滋, 古谷曜子, 棚橋祐典, 東寛, 中村雄一, 水島正人, 佐野仁美

    第53回日本小児内分泌学会学術集会 

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    Event date: 2019.9

    Language:Japanese   Presentation type:Poster presentation  

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  • PIT1β変異による複合型下垂体機能低下症の1家系

    鈴木滋, 松尾公美浩, 國米崇秀, 古谷曜子, 棚橋祐典, 東寛

    第92回日本内分泌学会学術総会 

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    Event date: 2019.5

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • 急性リンパ性白血病の診断契機となったFGF23高値を伴う高Ca血症

    鈴木 滋, 古谷 曜子, 棚橋 祐典, 櫻井 由香里, 鳥海 尚久, 更科 岳大, 佐藤 雅之, 坪田 朋佳, 東 寛

    第28回臨床内分泌代謝Update 

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    Event date: 2018.11

    Language:Japanese   Presentation type:Poster presentation  

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  • 思春期の血糖コントロールにグリベンクラミドの大幅な増量を要したKCNJ11遺伝子変異による新生児糖尿病の一例

    鈴木 滋, 向井 徳男, 古谷 曜子, 棚橋 祐典, 東 寛

    第61回日本糖尿病学会年次学術集会 

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    Event date: 2018.5

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • 131I内用療法を施行した小児期発症バセドウ病の臨床的検討

    鈴木 滋, 古谷曜子, 棚橋祐典, 東 寛, 松尾公美浩

    日本小児科学会北海道地方会第297回例会 

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    Event date: 2016.12

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  • ネフローゼ症候群を合併したp450 oxidoreductase異常症の一例

    古谷曜子, 石羽澤映美, 吉田陽一郎, 鈴木 滋, 高橋弘典, 松尾公美浩, 棚橋祐典, 東 寛

    第26回臨床内分泌代謝Update 

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    Event date: 2016.11

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  • Glycemic Control Indicators Levels at Diagnosis of Neonatal Diabetes Mellitus: Comparison with Other Types of Insulin-Dependent Diabetes Mellitus International conference

    Shigeru Suzuki, Akiko Furuya, Yusuke Tanahashi, Hiroshi Azuma, Yukihiro Bando, Soji Kasayama, Masafumi Koga

    第50回日本小児内分泌学会・第9回アジア太平洋小児内分泌学会合同学術集会 

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    Event date: 2016.11

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  • 持続皮下注からオクトレオチドLARに変更した先天性高インスリン血症の長期経過

    棚橋祐典, 古谷曜子, 鈴木滋, 松尾公美浩, 依藤亨, 東寛

    第50回日本小児内分泌学会学術集会 

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    Event date: 2016.11

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  • オクトレオチドLARにて治療している先天性高インスリン血症の一例

    棚橋祐典, 古谷曜子, 鈴木滋, 松尾公美浩, 東寛

    第16回日本内分泌学会北海道支部学術集会 

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    Event date: 2016.11

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  • 「小児・思春期糖尿病治療のさらなる課題 ~個別の対応が必要な事例とその実践~」新生児糖尿病のSU剤長期投与

    棚橋祐典, 鈴木 滋, 古谷曜子

    第22回日本小児・思春期糖尿病研究会年次学術集会 

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    Event date: 2016.7

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

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  • 黄疸で発症した肺炎球菌菌血症の一例

    鈴木滋, 赤羽裕一, 島田空知, 佐藤雅之, 青山藍子, 二井光麿, 山本志保, 竹田津原野, 佐藤敬, 向井徳男, 竹田津未生, 白井勝, 坂田宏, 沖潤一, 三浦純一

    日本小児科学会北海道地方会第296回例会 

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    Event date: 2016.6

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • 急性腎盂腎炎から腎膿瘍への悪化を認めた高IgE症候群の乳児例

    鈴木 滋, 島田 空知, 佐藤 雅之, 山本 志保, 竹田津 原野, 向井 徳男, 竹田津 未生, 坂田 宏, 沖 潤一

    第119回日本小児科学会学術集会 

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    Event date: 2016.5

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  • プロカルシトニン高値と小児感染症の重症度の解離 10ng/ml以上を示す51例の検討

    竹田津 原野, 島田 空知, 佐藤 雅之, 山本 志保, 鈴木 滋, 向井 徳男, 竹田津 未生, 白井 勝, 坂田 宏, 沖 潤一

    第119回日本小児科学会学術集会 

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    Event date: 2016.5

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  • 新生児糖尿病74症例における早期遺伝子診断の有用性

    古谷 曜子, 鈴木 滋, 松尾 公美浩, 棚橋 祐典, 東 寛

    第89回日本内分泌学会学術総会 

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    Event date: 2016.4

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • オクトレオチドLARに変更した先天性高インスリン血症の一例

    棚橋祐典, 古谷曜子, 鈴木滋, 松尾公美浩, 依藤亨, 東寛

    第25回臨床内分泌代謝update 

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    Event date: 2015.11

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  • 先天性副腎過形成症のマススクリーニングの現状の問題点と今後の展望 CAHの予後 特に成人身長および成人期副腎ホルモン補充療法について 全国疫学調査による解析

    棚橋 祐典, 鈴木 滋, 田島 敏広, 東 寛

    第42回日本マススクリーニング学会 

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    Event date: 2015.8

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

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  • 1型糖尿病児の出生から成人身長に至るまでの成長に関する検討

    松尾 公美浩, 古谷 曜子, 鈴木 滋, 棚橋 祐典, 東 寛

    第58回日本糖尿病学会学術集会 

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    Event date: 2015.5

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  • NDM患者において日齢補正GAは血糖を正しく反映する 血糖より求めた算出GAとの比較

    古谷 曜子, 鈴木 滋, 古賀 正史, 大島 美保, 雨宮 聡, 中尾 厚, 和田 佳子, 奥原 宏治, 早野 聡, 今本 彩, 松尾 公美浩, 棚橋 祐典, 東 寛

    第58回日本糖尿病学会学術集会 

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    Event date: 2015.5

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  • スルホニル尿素剤(SU剤)によるインスリン離脱ができなかったKCNJ11 R50P変異の一例

    鹿島田 健一, 滝島 茂, 小野 真, 高澤 啓, 鈴木 滋, 浦上 達彦

    第88回日本内分泌学会学術総会 

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    Event date: 2015.4

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  • SOX2遺伝子新規変異を同定した、視床下部過誤腫を有する低ゴナドトロピン性性腺機能低下症の一例

    松尾 公美浩, 古谷 曜子, 鈴木 滋, 上田 修, 向井 徳男, 棚橋 祐典, 東 寛

    第88回日本内分泌学会学術総会 

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    Event date: 2015.4

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  • KCNJ11変異を伴う新生児糖尿病2症例のスルホニルウレア剤による長期治療経過

    古谷 曜子, 岡 秀治, 鈴木 滋, 松尾 公美浩, 荒木 章子, 棚橋 祐典, 大島 美保, 岡 敏明, 向井 徳男, 東 寛

    第118回日本小児科学会学術集会 

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    Event date: 2015.4

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  • aripiprazole開始後より血糖上昇を呈した新生児糖尿病の一例

    松尾 公美浩, 向井 徳男, 鈴木 滋, 古谷 曜子, 荒木 章子, 棚橋 祐典, 東 寛

    第24回臨床内分泌代謝update 

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    Event date: 2014.11

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  • SIRT1 enhances the transcriptional activity of the glucocorticoid receptor in its deacetylase activity-independent fashion International conference

    Shigeru Suzuki, Tomoshige Kino

    16th International Congress of Endocrinology & the Endocrine Society 96th Annual Meeting 

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    Event date: 2014.6

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  • 新生児糖尿病患者において発症時のグリコアルブミンは日齢と血糖の積に相関する

    古谷 曜子, 鈴木 滋, 古賀 正史, 大島 美保, 雨宮 聡, 中尾 厚, 荒木 まり子, 水谷 佳世, 早野 聡, 牛嶌 克実, 今本 彩, 長野 伸彦, 浦上 達彦, 松尾 公美浩, 棚橋 祐典, 東 寛

    第57回日本糖尿病学会学術集会 

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    Event date: 2014.5

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  • 二次性夜尿の出現を認めた限局性強皮症合併バセドウ病の一例

    松尾 公美浩, 島田 空知, 古谷 曜子, 鈴木 滋, 古谷野 伸, 棚橋 祐典, 東 寛

    第87回日本内分泌学会学術総会 

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    Event date: 2014.4

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  • 幼児期にKAL1遺伝子欠失をMLPA法により同定し確定診断に至ったKallmann症候群の一例

    棚橋 祐典, 鈴木 滋, 松尾 公美浩, 古谷 曜子, 向井 徳男

    第87回日本内分泌学会学術総会 

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    Event date: 2014.4

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  • 年齢補正したグリコアルブミンは新生児糖尿病の血糖コントロール指標として有用である

    棚橋 祐典, 鈴木 滋, 古賀 正史, 新関 紀康, 古谷 曜子, 松尾 公美浩, 東 寛

    第56回日本糖尿病学会学術集会 

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    Event date: 2013.5

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • 新生児糖尿病患者のHbA1cの有用時期の検討

    古谷 曜子, 鈴木 滋, 古賀 正史, 大島 美保, 雨宮 聡, 中尾 厚, 和田 佳子, 奥原 宏治, 早野 聡, 松尾 公美浩, 棚橋 祐典, 東 寛

    第56回日本糖尿病学会学術集会 

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    Event date: 2013.5

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  • 成長ホルモン療法開始後に皮膚症状の改善を認めた、炎症型peeling skin病を合併する成長ホルモン分泌不全性低身長症の一例

    松尾 公美浩, 古谷 曜子, 鈴木 滋, 棚橋 祐典, 井川 哲子, 山本 明美, 東 寛

    第86回日本内分泌学会学術総会 

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    Event date: 2013.4

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  • グリコアルブミンは先天性高インスリン血性低血糖症患者の血糖コントロール指標として有用である

    古谷 曜子, 鈴木 滋, 古賀 正史, 七尾 謙治, 松尾 公美浩, 棚橋 祐典, 東 寛

    第86回日本内分泌学会学術総会 

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    Event date: 2013.4

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  • 脂肪肝と2型糖尿病を合併したAlagille症候群の一例

    古谷 曜子, 鈴木 滋, 高橋 弘典, 長森 恒久, 松尾 公美浩, 古谷野 伸, 棚橋 祐典, 東 寛, 蒔田 芳男, 向井 徳男

    第116回日本小児科学会学術集会 

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    Event date: 2013.4

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  • 日齢2に発症した一過性新生児糖尿病の例

    水落 弘美, 大曽根 義輝, 石田 智己, 佐々木 恒, 富田 美佳, 木下 香, 古谷 曜子, 鈴木 滋

    第116回日本小児科学会学術集会 

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    Event date: 2013.4

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  • リラグルチドが有効であった2型糖尿病の14歳女児例

    古谷曜子, 岡山亜貴恵, 鈴木滋, 松尾公美浩, 棚橋祐典, 東寛

    第285回日本小児科学会北海道地方会 

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    Event date: 2012.11

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  • GATA6遺伝子に新規変異を認めた膵形成不全による新生児糖尿病の2例

    鈴木滋, 中尾厚, 稲垣塩見, Sarhat Ashoor, 古谷曜子, 松尾公美浩, 棚橋祐典, 岡嶋一樹, 松本直也, 梶野浩樹, 東寛, 藤枝憲二

    第46回日本小児内分泌学会学術集会 

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    Event date: 2012.9

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  • 高ALP血症を認めないビタミンD欠乏性くる病の一例

    松尾公美浩, 古谷曜子, 鈴木滋, 棚橋祐典, 向井徳男, 東寛

    第46回日本小児内分泌学会学術集会 

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    Event date: 2012.9

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  • Methylation PCR法により診断されたPrader-Willi症候群の13歳女児例

    島田 空知, 古谷 曜子, 鈴木 滋, 松尾 公美浩, 高橋 悟, 棚橋 祐典, 東 寛

    第62回北日本小児科学会学術集会 

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    Event date: 2012.9

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  • paternal UPD6による新生児一過性糖尿病症例におけるインスリン分泌回復の指標としてのHOMA-βの検討

    安原肇, 美馬文, 池田由香, 恵美須礼子, 扇谷綾子, 箕輪秀樹, 鈴木滋

    第48回日本周産期・新生児医学会学術集会 

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    Event date: 2012.7

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  • 新生児仮死後の遷延性高血糖を契機に、KCNJ11遺伝子変異を認めた新生児糖尿病の一例

    成瀬裕紀, 喜田善和, 吉田和司, 布山裕一, 園田結子, 長澤耕男, 池原甫, 白神一博, 鈴木滋

    第48回日本周産期・新生児医学会学術集会 

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    Event date: 2012.7

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  • Glycated Albumin in Infants is lower than that in Adults and Correlate with both Age and Albumin International conference

    Shigeru Suzuki, Masafumi Koga, Noriyasu Niizeki, Akiko Furuya, Hironori Takahashi, Kumihiro Matsuo, Yusuke Tanahashi, Tomomi Kawata, Hiroko Asai, Etsushi Tsuchida, Fumikatsu Nohara, Toshio Okamoto, Ken Nagaya, Hiroshi Azuma

    ADA 72nd Scientific Sessions 

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    Event date: 2012.6

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  • 過去の経時的な血糖値を用いてHbA1c、GAを算出する

    古賀正史, 鈴木滋, 松尾公美浩, 棚橋祐典, 笠山宗正

    第55回日本糖尿病学会年次学術集会 

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    Event date: 2012.5

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  • 乳児のグリコアルブミンは成人基準値に比し低値を示し、日齢およびアルブミンと強く正相関する

    鈴木滋, 古賀正史, 新関紀康, 川田知美, 浅井洋子, 土田悦司, 野原史勝, 岡本年男, 長屋建, 高橋弘典, 松尾公美浩, 棚橋祐典, 東寛

    第55回日本糖尿病学会年次学術集会 

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    Event date: 2012.5

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  • アフィニティ法のグリコヘモグロビン(GHb)あるいはHbF値で補正したGHbは乳児の血糖コントロール指標になりうるか?

    棚橋祐典, 鈴木滋, 古賀正史, 新関紀康, 川田知美, 浅井洋子, 土田悦司, 野原史勝, 岡本年男, 長屋建, 高橋弘典, 松尾公美浩, 東寛

    第55回日本糖尿病学会年次学術集会 

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    Event date: 2012.5

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  • 新生児糖尿病のグリコアルブミンは血糖に比し低値を示す - 小児1型糖尿病との比較 -

    鈴木滋, 古賀正史, 松尾公美浩, 棚橋祐典

    第85回日本内分泌学会学術総会 

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    Event date: 2012.4

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  • 慢性低血糖症特にインスリノーマにおけるHbA1c測定の有用性

    古賀正史, 村井潤, 斎藤博, 鈴木滋, 棚橋祐典, 笠山宗正

    第85回日本内分泌学会学術総会 

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    Event date: 2012.4

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  • インスリノーマの診断のためのFPG/FIRI比の新たなカットオフ値の提案

    村井潤, 斎藤博, 鈴木滋, 棚橋祐典, 笠山宗正, 古賀正史

    第85回日本内分泌学会学術総会 

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    Event date: 2012.4

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  • Carney複合(CNC)の全国調査結果

    向井徳男, 鈴木滋, 松尾公美浩, 棚橋祐典

    第85回日本内分泌学会学術総会 

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    Event date: 2012.4

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  • グリコアルブミンの新生児糖尿病の血糖管理指標(血糖コントロールマーカー;研究会用)としての有用性の検討

    鈴木滋, 古賀正史, 浅井洋子, 土田悦司, 野原史勝, 岡本年男, 長屋建

    第56回日本未熟児新生児学会学術集会 

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    Event date: 2011.11

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • グリコアルブミンの新生児糖尿病における血糖コントロール指標としての有用性と健常乳児における検討

    鈴木滋, 古賀正史, 雨宮聡, 中尾厚, 和田佳子, 奥原宏治, 早野聡, 高橋弘典, 松尾公美浩, 棚橋祐典, 浅井洋子, 土田悦司, 野原史勝, 岡本年男, 長屋建, 藤枝憲二

    第45回小児内分泌学会学術集会 

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    Event date: 2011.10

    Language:Japanese   Presentation type:Poster presentation  

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  • 小児慢性特定疾患治療研究事業における21水酸化酵素欠損症の解析

    鈴木滋, 横谷進

    第45回小児内分泌学会学術集会 

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    Event date: 2011.10

    Language:Japanese   Presentation type:Poster presentation  

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  • KCNJ11遺伝子変異による新生児糖尿病と診断し、インスリンからglibenclamide内服へ変更可能であった1例

    鈴木滋, 岡山亜貴恵, 高橋弘典, 松尾公美浩, 向井徳男, 棚橋祐典, 荒木章子, 雨宮聡, 大島美保, 岡敏明

    第63回北日本小児科学会 

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    Event date: 2011.9

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • Glycated albumin is a useful indicator of glycemic control in patients with neonatal diabetes mellitus International conference

    Shigeru Suzuki, Masafumi Koga, Noriyasu Niizeki, Satoshi Amamiya, Atsushi Nakao, Keiko Wada, Koji Okuhara, Satoshi Hayano, Hironori Takahashi, Kumihiro Matsuo, Fumikatsu Nohara, Toshio Okamoto, Ken Nagaya, Tokitsugi Hayashi, Yusuke Tanahashi, Kenji Fujieda

    ADA 71st Scientific Sessions 

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    Event date: 2011.6

    Language:English   Presentation type:Poster presentation  

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  • グリコアルブミン(GA)は新生児糖尿病の血糖コントロール指標として有用性である

    鈴木滋, 古賀正史, 雨宮聡, 中尾厚, 和田佳子, 奥原宏治, 早野聡, Sarhat Ashoor R., 高橋弘典, 松尾公美浩, 棚橋祐典, 藤枝憲二

    第54回日本糖尿病学会年次学術集会 

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    Event date: 2011.5

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • GT1-7細胞におけるKisspeptinに対するGnRH遺伝子および分泌の概日リズム振動への影響の検討

    棚橋祐典, 鈴木滋, 松尾公美浩, 本間さと, 本間研一

    第84回日本内分泌学会学術総会 

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    Event date: 2011.4

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  • 「副腎ホルモン産生異常症実態把握のための全国疫学調査」に関する報告

    向井徳男, 鈴木滋, 棚橋祐典, 藤枝憲二

    第84回日本内分泌学会学術総会 

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    Event date: 2011.4

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  • 内科的治療にて血糖コントロール中の、ABCC8遺伝子複合ヘテロ接合変異による持続性先天性高インスリン血症の一例

    鈴木滋, 松尾公美浩, 依藤亨, 棚橋祐典, 藤枝憲二

    第84回日本内分泌学会学術総会 

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    Event date: 2011.4

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  • Kaufmann療法中に妊娠、出産した小児期造血幹細胞移植施行の2例

    鈴木滋, 松尾公美浩, 伊藤善也, 吉田真, 棚橋祐典, 藤枝憲二

    第20回臨床内分泌代謝Update 

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    Event date: 2011.1

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  • 3T-MRIでの早期診断により多尿を治療し得たgerminoma再発の一例

    松尾公美浩, 鳥海尚久, 更科岳大, 鈴木滋, 中右弘一, 加藤良久, 須貝理香, 向井徳男, 棚橋祐典, 吉田真, 澤村豊, 藤枝憲二

    第20回臨床内分泌代謝Update 

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    Event date: 2011.1

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  • KCNJ11遺伝子変異による新生児糖尿病に対する4年間のスルホニルウレア治療経過とインスリン分泌評価

    鈴木滋, 向井徳男, 松尾公美浩, 棚橋祐典, 藤枝憲二

    第44回日本小児内分泌学会学術集会 

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    Event date: 2010.10

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  • インスリンからスルホニルウレアへ治療変更に成功したKCNJ11遺伝子変異による新生児糖尿病の一例:4年間の治療経過とインスリン分泌評価

    鈴木滋, 向井徳男, 松尾公美浩, 棚橋祐典, 藤枝憲二

    第10回日本内分泌学会北海道地方会 

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    Event date: 2010.10

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  • Clinical implications of a molecular genetic classification for neonatal diabetes mellitus International conference

    Shigeru Suzuki, Mireguli Maimaiti, Kumihiro Matsuo, Yusuke Tanahashi, Tokuo Mukai, Kenji Fujieda

    International Symposium on Pediatric Endocrinology Official ICE 2010 Satellite Symposium 

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    Event date: 2010.3 - 2010.4

    Language:English   Presentation type:Oral presentation (general)  

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  • Analysis of Insulin gene mutation in Japanese patients with permanent neonatal diabetes mellitus and child-onset insulin dependent diabetes mellitus International conference

    Suzuki S., Horiuchi K., Santo Y., Tsubouchi K., Maimaiti M., Matsuo K., Tanahashi Y., Mukai T., Fujieda K.

    14th International Congress of Endocrinology 

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    Event date: 2010.3

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Awards

  • 第24回小児分子内分泌研究会 優秀演題賞

    2021.7   小児分子内分泌研究会  

    鈴木 滋

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    Country:Japan

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  • 第16回小児分子内分泌研究会

    2012.7   小児分子内分泌研究会  

    鈴木 滋

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    Country:Japan

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  • 旭川医科大学小児科学教室若手研究奨励賞

    2010.12   旭川医科大学小児科  

    鈴木 滋

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  • ノボノルディスク成長・発達研究賞2009

    2009.5   ノボノルディスク  

    鈴木 滋

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    Country:Japan

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  • 旭川医科大学小児科 吉岡賞

    2008.7   旭川医科大学小児科  

    鈴木 滋

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    Country:Japan

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  • 1st Congress of Asian Society for Pediatric Research“Young Investigator’s Award”

    2005.11   Asian Society for Pediatric Research  

    鈴木 滋

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    Award type:Award from international society, conference, symposium, etc.  Country:Japan

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  • 第39回小児内分泌学会学術集会「優秀演題賞」

    2005.10   日本小児内分泌学会  

    鈴木 滋

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Research Projects

  • ヒト病理検体と細胞実験および疾患モデルマウス用いたNBAS遺伝子の骨成長およびインスリン分泌における役割の解明

    2022.4 - 2024.3

    民間財団等 

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  • クリスビータ皮下注 特定使用成績調査 ―FGF23関連低リン血症性くる病・骨軟化症患者の長期使用に関する調査―

    2021.11 - 2027.12

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  • TS-071の小児2型糖尿病患者を対象とした第Ⅲ相プラセボ対照二重盲検比較/長期投与試験

    2021.6 - 2025.3

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  • 新たな単一遺伝子異常による糖尿病としてのNBAS遺伝子異常症の疾患概念の確立

    2021.4 - 2022.3

    公益財団法人日本糖尿病財団 

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  • NBAS遺伝⼦異常症の病態解明:肝不全、低⾝⻑ならびに糖尿病発症・進展のメカニズム解明を⽬指して

    2021.4 - 2022.3

    川野⼩児医学奨学財団 

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  • NBAS遺伝子異常による成長障害の病態解明

    2021.4 - 2022.3

    JCRファーマ(株) 

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  • 注入時の刺激低減を目的とした成長ホルモン製剤の新処方液剤が低身長児の服薬アドヒアランスに及ぼす影響に関する探索的検討

    2020.11 - 2021.12

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  • 1A型糖尿病におけるインスリン開始前の低血糖に関する前向き観察研究

    2020.5 - 2021.9

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  • グルカゴンの小児おける基準値設定と小児糖尿病および肥満症例における分泌動態の検討

    2019.11 - 2021.3

    日本小児内分泌学会 

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  • 成長ホルモン治療における服薬アドヒアランスに対するスマートフォンアプリケーションソフトウェアの有用性の探索的検討

    2019.7 - 2020.12

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  • 小児期発症の萎縮性甲状腺炎における阻害型 TSH 受容体抗体の関与の検討

    2019.1 - 2020.3

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  • ノルディトロピン®(ヌーナン症候群における低身長)長期使用に関する特定使用成績調査

    2018.6 - 2021.11

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  • A PHASE 3, OPEN-LABEL, RANDOMIZED, MULTICENTER, 12-MONTH, EFFICACY AND SAFETY STUDY OF WEEKLY MOD-4023 COMPARED TO DAILY GENOTROPINⓇ THERAPY IN JAPANESE PRE-PUBERTAL CHILDREN WITH GROWTH HORMONE DEFICIENCY 思春期前の日本人小児成長ホルモン分泌不全性低身長症患者を対象にMOD-4023の週1回投与の有効性及び安全性をジェノトロピン®の連日投与と比較評価する、12カ月間の第Ⅲ相、非盲検、ランダム化、多施設共同試験

    2017.11 - 2022.12

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  • 先天性下垂体機能低下症の新たな発症機構の解明:Pit-1β変異の機能解析

    2016.12 - 2018.3

    寿原記念財団 

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  • 先天性下垂体機能低下症の新たな発症機構の解明:PIT1βの機能解析

    2016.11 - 2018.9

    日本小児内分泌学会 

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  • 先天性下垂体機能低下症の新たな発症機構の解明:PIT-1β変異の機能解析

    2016.4 - 2018.3

    科学研究費補助金 

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  • グロウジェクトのSGA性低身長症における特定使用成績調査

    2013.8 - 2022.3

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  • 新生児糖尿病の包括的研究:新規責任遺伝子の探索ならびに血糖管理指標の確立

    2012.4 - 2014.3

    若手研究(B)

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    新生児糖尿病(neonatal diabetes mellitus, 以下NDM)は、生後6か月以内に発症する遺伝子異常による糖尿病と定義され、膵β細胞の発生、機能に関わる13の責任遺伝子が同定されている。我々は、日本人における分子疫学および臨床像を明らかにしてきた。しかし、約30%の症例で既知遺伝子に異常は認められない。また、我々は、NDMの血糖管理指標として、グリコアルブミン(GA)の有用性を初めて報告したが、健常児における検討はない。従って、本研究では、次世代シークエンサーにより網羅的に新規責任遺伝子の同定を試みること、さらに乳児のGA基準値設定およびその動態を明らかにすることを目的とし、基礎・臨床両面からNDMの包括的解析を行う。

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  • 新生児糖尿病の包括的研究:新規責任遺伝子の探索ならびに血糖管理指標の確立

    2012.4 - 2012.12

    科学研究費補助金 

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  • 新生児糖尿病の網羅的な病因・病態の解明と分子診断アルゴリズムの作成

    2009.4 - 2012.3

    科学研究費補助金 

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  • 新生児糖尿病の網羅的な病因・病態の解明と分子診断アルゴリズムの作成

    2009.4 - 2012.3

    若手研究(B)

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    日本人新生児糖尿病65例中、53例(81.5%)の原因遺伝子を同定した。染色体6q24異常、KCNJ11遺伝子変異がともに約30%で認められ、前者は一過性糖尿病の、後者は永続性の主たる原因であるとともに、ABCC8遺伝子、INS遺伝子、GATA6遺伝子、FOXP3遺伝子が日本人患者で認められた。6番染色体部分ダイソミーが一過性糖尿病を招くこと、GATA6遺伝子異常が先天性心疾患、内臓奇形を合併する膵形成不全を来すことを見いだした。

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  • グロウジェクトの成長ホルモン分泌不全性低身長症における特定使用成績調査(長期使用に関する調査)

    2008.1 - 2022.3

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  • 副腎皮質機能低下症における副腎クリーゼ発症の前向き観察研究

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  • 小児期発症日本人1型糖尿病患者の長期予後エビデンスの構築と治療への応用

    基盤研究(C)

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    小児期発症日本人1型糖尿病患者の長期予後エビデンスの構築と治療への応用

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  • ヒト病理検体と疾患モデル細胞およびマウスを用いたNBAS遺伝子異常症の病態解明

    基盤研究(C)

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    Neuroblastoma amplified sequence(NBAS)遺伝子異常症は、重度の低身長、骨粗鬆症、骨形成不全症、乳児期の反復性急性肝不全、免疫異常、インスリン分泌不全による糖尿病、視神経萎縮等を発症しうる先天性の難治性疾患として、近年報告された疾患概念である。NBASの種々の臓器における生理機能は不明であり、従って、NBAS遺伝子異常症がどのようにそれらの臓器障害を起こすのかについて解明されていない。申請者は、長期にわたりフォローしたNBAS遺伝子異常症症例の臨床像を報告し、本症の皮膚線維芽細胞、剖検組織を保有している。本研究の目的は、これらのヒト検体および病態モデルとしての細胞株、およびノックアウトマウスを用いて、NBASの生理機能およびNBAS遺伝子異常症の分子病態解明を行うことである。種々の臓器に影響を及ぼすNBASの機能未知の解明は、本症の治療法開発のみならず、同様の病態を呈する疾患治療戦略への示唆を与えると考えられる。

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  • 小児期発症1型糖尿病の治療・予後改善のための多施設共同研究(第5コホート)

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  • 小児期発症の希少難治性肝胆膵疾患における医療水準並びに患者QOLの向上のための調査研究

    厚生労働省 

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  • ヒト病理検体と疾患モデル細胞およびマウスを用いたNBAS遺伝子異常症の病態解明

    科学研究費補助金 

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  • 新生児糖尿病の分子基盤解明と診断・治療戦略の構築

    科学研究費補助金 

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  • 小児期発症の萎縮性甲状腺炎における阻害型 TSH 受容体抗体の関与の前方視的検討

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  • JCR奨学寄附プログラム

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    Grant type:Competitive

    Grant amount:\500,000

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  • Noonan症候群類縁疾患の遺伝子解析研究

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  • 北海道小児期発症1型糖尿病児の長期予後に関する研究

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Social Activities

  • 第13回北海道看護師勉強会

    2018.4

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Academic Activities

  • 「臨床小児医学」編集委員

    2023.4

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  • 北海道小児保健研究会幹事

    2023.4

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  • 日本小児内分泌学会北海道地方会世話人

    2023.1

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  • 日本小児科学会北海道地方会幹事

    2022.4

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  • 北海道思春期研究会幹事

    2022.4

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  • 日本小児内分泌学会広報委員会

    2022.1

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  • 日本小児内分泌学会糖代謝委員会

    2022.1

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  • 日本小児内分泌学会卒後教育委員会

    2022.1

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  • 日本内分泌学会北海道支部コンサルタント副委員長

    2021.4

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  • 「臨床小児医学」査読委員

    2019.4

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  • 日本内分泌学会評議員

    2017.4

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  • 日本小児内分泌学会倫理委員会委員

    2017.4 - 2021.12

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  • 日本小児内分泌学会成長曲線管理委員会委員

    2017.4 - 2021.12

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  • 北海道小児内分泌研究会世話人

    2016.4

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    【教員評価対象外項目:地方学会】

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  • 日本小児内分泌学会評議員

    2014.4

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  • 日本小児・思春期糖尿病学会評議員

    2013.4

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  • 日本小児内分泌学会あり方委員会

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