Updated on 2026/04/01

写真a

 
KAN-NO Kyoko
 
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University Institutions Family Support Center
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Papers

  • Examining Changes in Medical Student's Attitudes Toward Work-Life Balance in the Classroom: A Comparison of 2012 and 2022 Reviewed

    Kyoko Kanno

    56 ( 5 )   305 - 310   2025.10

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  • Pathogenesis of Pseudocheckerboard Pattern in Mechanic's Hands Reviewed International journal

    Kyoko Kanno

    Journal of Dermatology   52 ( 9 )   1418 - 1423   2025.9

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    Among the relatively common manifestations of dermatomyositis (DM), "mechanic's hands" refer to symmetric hyperkeratotic erythematous lesions on the ulnar aspect of the thumbs and the radial aspect of the index and middle fingers. The "pseudocheckerboard pattern" is a distinct histopathological finding associated with mechanic's hands. This pattern consists of vertical keratotic columns in the stratum corneum, some of which display a striped appearance characterized by alternating bands of orthokeratosis and parakeratosis in both vertical and horizontal orientations. Although this phenomenon is well documented, its underlying mechanism remains poorly understood. In this study, we collected tissue samples from 14 patients with DM accompanied by mechanic's hands and reviewed their clinical presentations and histopathological features. We identified several common histopathological findings of DM, including the characteristic pseudocheckerboard pattern associated with these lesions. Parakeratotic foci of the pseudocheckerboard pattern were observed within the stratum corneum, corresponding to the suprapapillary epidermis, where both CD4- and CD8-positive lymphocytes infiltrated the papillary dermis and suprapapillary epidermis. A portion of these lymphocytes expressed interleukin (IL)-17, and the number of IL-17-positive cells was comparable to that in psoriatic skin lesions. The inflammatory response was relatively confined to the papillary dermis and suprapapillary epidermis, suggesting that Th17-mediated epidermal hyperplasia may be involved in the pathogenesis of mechanic's hands.

    DOI： 10.1111/1346-8138.17826

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  • Malignant Transformation From Seborrheic Keratosis to Squamous Cell Carcinoma Is More Likely to Occur in Nonexposed Areas: A Single-Center Retrospective Study. International journal

    Hiroyoshi Nozaki, Akemi Ishida-Yamamoto, Tomoe Nakagawa, Kaori Umekage, Kyoko Kanno, Masaru Honma, Mari Kishibe

    The Journal of dermatology   52 ( 7 )   e618-e619   2025.7

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  • 小児の下顎に生じたLipofibromatosisの1例 Invited Reviewed

    菅野恭子

    日本小児皮膚科学会誌   44 ( 2 )   107 - 112   2025.6

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    Authorship：Lead author   Language：Japanese   Publisher：日本小児皮膚科学会  

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  • Potential thioflavin T false positives in lipomembranous changes in adipocytes during systemic amyloidosis diagnosis. International journal

    Mari Kishibe, Kaori Umekage, Hiroyoshi Nozaki, Tomoe Nakagawa, Kyoko Kanno, Akira Manabe, Akemi Ishida-Yamamoto

    The Journal of dermatology   52 ( 1 )   171 - 174   2025.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    The diagnosis of systemic amyloidosis relies on the detection of amyloid deposition in the tissue, often utilizing biopsy specimens from the abdominal skin owing to their minimal invasiveness. Several amyloid staining methods, including Congo Red, Direct Fast Scarlet (DFS), and Thioflavin T (ThT), have been employed for visualization. Lipomembranous fat necrosis (LFN) is a non-specific reaction pattern of adipose tissue to injury, typically derived from blood insufficiency across a wide range of clinical conditions or diseases. It is characterized by the presence of eosinophilic, crenulated, and/or serpiginous membranes in fat lobules. We encountered a patient in whom ThT yielded suspiciously positive results in amyloidosis screening tests. Furthermore, our retrospective observations suggested that ThT staining was positive for LFN, whereas DFS and Congo red staining yielded negative results. The awareness that LFN can result in false-positive ThT staining during amyloid screening is crucial to avoiding the misdiagnosis of systemic amyloidosis. Furthermore, skin samples should not be collected from areas prone to developing lipomembranous changes. The use of more than two different stains for skin biopsy specimens is recommended.

    DOI： 10.1111/1346-8138.17476

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  • Autoimmunity-related neutrophilic dermatosis after coronavirus disease 2019 vaccination: A case report and literature review Reviewed International journal

    Mari Kishibe, Katuya Koike, Kyoko Kanno, Akemi Ishida Yamamoto

    Journal of Dermatology   50 ( 6 )   820 - 823   2023.6

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    Autoimmune diseases triggered by coronavirus disease 2019 (COVID-19) mRNA vaccination have been emerging. Here, we report the case of a 27-year-old Japanese man with autoimmunity-related neutrophilic dermatosis, occurring as an initial cutaneous manifestation of systemic lupus erythematosus with Sjögren syndrome after the second dose of the Pfizer/BioNTech COVID-19 vaccination. The patient presented with urticarial erythema and partially annular erythema on the trunk and extremities with severe pruritus. Histopathological analysis showed vacuolar degeneration at the dermo-epidermal junction and interstitial neutrophil infiltration. We reviewed eight patients, including the aforementioned patient, with exacerbation or new-onset of SLE after COVID-19 vaccination and found the patient had relatively mild symptoms, itchy annular erythema, and positive anti-SS-A/SS-B antibodies. COVID-19 mRNA vaccination can induce the production of type-I interferon, which plays a crucial role in the pathogenesis of SLE and may cause autoimmunity-related neutrophilic dermatosis in susceptible individuals. In the case that itchy annular erythema develops approximately 2 weeks after the vaccination, the possibility of systemic or cutaneous lupus erythematosus should be considered. For an accurate diagnosis, dermatologists should obtain a recent vaccination history and perform complete antibody profiling and skin biopsy for patients presenting with annular or erythema multiforme-like lesions.

    DOI： 10.1111/1346-8138.16718

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  • TODAY’S THERAPY Reviewed International journal

    Nose M., Kanno K., Komtus M.Kobayashi T., Fujii M., Umekage K., Ootubo S. Ishida- Yamamoto A

    Australas J Dermatol   64 ( 2 )   288 - 291   2023.3

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/ajd.13993

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  • Pathology and Clinical Medicine Invited Reviewed

    Kyoko Kanno

    40 ( 7 )   685 - 689   2022.7

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    Authorship：Lead author   Language：Japanese  

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  • Kawasaki disease in adolescence and adulthood: Report of four cases. International journal

    Hiroyuki Sakai, Masako Minami-Hori, Tomoe Shimamura, Kyoko Kanno

    The Journal of dermatology   48 ( 12 )   1940 - 1944   2021.12

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    Kawasaki disease (KD) in adolescence and adulthood is often underrecognized, because KD predominantly affects infants and young children below the age of 5 years. We report four cases of KD in patients 16-32 years of age. The first department that the patients visited was the Department of Otolaryngology, Obstetrics, or General Internal Medicine. Since KD almost always develops as cutaneous and mucosal manifestations, dermatologists have a particularly significant role in diagnosing KD in adolescents and adults. KD should be kept in mind for febrile patients of any age group presenting with exanthem.

    DOI： 10.1111/1346-8138.16168

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  • Dasatinib-induced panniculitis in a patient with chronic myeloid leukaemia. International journal

    Yusuke Nagasawa, Shin Iinuma, Mizue Fujii, Kyoko Kanno, Masaru Honma, Sayaka Yuzawa, Akemi Ishida-Yamamoto

    European journal of dermatology : EJD   31 ( 1 )   87 - 88   2021.2

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  • Inclusion bodies are not uncommon in angioleiomyoma Reviewed International journal

    Mari Kishibe, Satomi Igawa, Kyoko Kanno, Akemi Ishida-Yamamoto

    Journao of cutaneous pathology   48 ( 2 )   269 - 273   2021.2

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Leiomyomas with eosinophilic intracytoplasmic inclusion bodies have been described in the urinary bladder, brain, gastrointestinal tract, uterus, and oral cavity but not in the skin. Prompted by our recent experience with a case of cutaneous angioleiomyoma with many inclusion bodies, we hypothesized that similar cases might have been previously overlooked. METHODS: We retrospectively reviewed 30 cases of angioleiomyoma and 10 cases of piloleiomyoma focusing on inclusion bodies. RESULTS: More than 18 inclusion bodies per 250 μm squared were detected in five cases of angioleiomyoma, fewer than 11 bodies in 20 cases, and none in five cases. For the case with numerous inclusion bodies throughout the specimen, special staining was needed to make a diagnosis. No inclusion bodies were found in the piloleiomyomas. CONCLUSION: Inclusion bodies are relatively common in angioleiomyomas and can occasionally be numerous. They may serve as a point of distinction from piloleiomyomas. Because the presence of multiple eosinophilic intracytoplasmic inclusions can result in a rhabdoid appearance and make diagnosis challenging, we should be aware of this feature in angioleiomyomas.

    DOI： 10.1111/cup.13891

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  • Increased Circulating Cell-Free DNA in Eosinophilic Granulomatosis With Polyangiitis: Implications for Eosinophil Extracellular Traps and Immunothrombosis. International journal

    Teppei Hashimoto, Shigeharu Ueki, Yosuke Kamide, Yui Miyabe, Mineyo Fukuchi, Yuichi Yokoyama, Tetsuya Furukawa, Naoto Azuma, Nobuyuki Oka, Hiroki Takeuchi, Kyoko Kanno, Akemi Ishida-Yamamoto, Masami Taniguchi, Akira Hashiramoto, Kiyoshi Matsui

    Frontiers in immunology   12   801897 - 801897   2021

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    BACKGROUND: Endogenous DNA derived from nuclei or mitochondria is released into the blood circulation as cell-free DNA (cfDNA) following cell damage or death. cfDNA is associated with various pathological conditions; however, its clinical significance in antineutrophil cytoplasmic antibody-associated vasculitis (AAV) remains unclear. This study aimed to evaluate the clinical significance of cfDNA in AAV. METHODS: We enrolled 35 patients with AAV, including 10 with eosinophilic granulomatosis with polyangiitis (EGPA), 13 with microscopic polyangiitis, and 12 with granulomatosis with polyangiitis. Serum cf-nuclear DNA (cf-nDNA) and cf-mitochondrial DNA (cf-mtDNA) levels were measured by quantitative polymerase chain reaction before and after the initiation of immunosuppressive therapy. Tissue samples from EGPA patients were examined by immunofluorescence and transmission electron microscopy. The structure of eosinophil extracellular traps (EETs) and neutrophil extracellular traps (NETs) and stability against DNase were assessed in vitro. Platelet adhesion of EETs were also assessed. RESULTS: Serum cf-nDNA and cf-mtDNA levels were significantly higher in AAV than in healthy controls, with the highest levels in EGPA; however, serum DNase activities were comparable among all groups. cf-nDNA and cf-mtDNA decreased after treatment and were associated with disease activity only in EGPA. Blood eosinophil count and plasma D-dimer levels were significantly correlated with cf-nDNA in EGPA and cf-mtDNA. EGPA tissue samples showed lytic eosinophils and EETs in small-vessel thrombi. The structure of EETs showed bolder net-like chromatin threads in vitro and EETs showed greater stability against DNase than NETs. EETs provided a scaffold for platelet adhesion. CONCLUSION: cfDNA was increased in EGPA, associated with disease activity. The presence of DNase-resistant EETs in small-vessel thrombi might contribute to higher concentration of cfDNA and the occurrence of immunothrombosis in EGPA.

    DOI： 10.3389/fimmu.2021.801897

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  • Dermoscopy of Bier spots Reviewed International journal

    Kenta Sasaki, Shin Iinuma, Naoki Tsuruta, Kyoko Kanno, Mari Kishibe, Masaru Honma, Akemi Ishida-Yamamoto

    European Journal of Dermatology   30 ( 3 )   300 - 301   2020.6

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    Authorship：Corresponding author   Language：English  

    DOI： 10.1684/ejd.2020.3789

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  • Radiation recall dermatitis induced by mogamulizumab Reviewed International journal

    K Sasaki, S Iinuma, M Fuji, T Shibuya, K Kanno, M Honma Hatayama, A Ishida-Yamamoto

    J Eur Acad Dermatol Venereol   34 ( 2 )   107 - 108   2020.2

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    Authorship：Corresponding author   Language：English  

    DOI： 10.1111/jdv.16033

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  • Cutaneous thrombosis associated with eltrombopag treatment for immune thrombocytopenia. International journal

    Shin Iinuma, Yusuke Nagasawa, Kenta Sasaki, Kei Hayashi, Kyoko Kanno, Masaru Honma, Motoshi Sugawara, Motoshi Kinouchi, Masahiko Obata, Akemi Ishida-Yamamoto

    The Journal of dermatology   47 ( 2 )   e57-e58   2020.2

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  • Histopathological Findings and Increased D-Dimer Are Predictive Factors of Systemic Thromboses in Eosinophilic Granulomatosis With Polyangiitis. International journal

    Kyoko Kanno, Masako Minami-Hori, Masaru Honma, Akemi Ishida-Yamamoto

    The American Journal of dermatopathology   40 ( 12 )   879 - 883   2018.12

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    Eosinophilic granulomatosis with polyangiitis (EGPA; ie, Churg-Strauss syndrome) is one of the antineutrophil cytoplasmic antibody-associated vasculitis syndromes. Although extravascular granulomatoses are a well-known histopathological feature, the diverse histopathologic spectrum of cutaneous lesions has not been described in detail. Thus, this study sought to investigate the possible correlation between the clinical features and histopathology of cutaneous lesions in EGPA cases, focusing on systemic thrombogenic conditions, such as visceral infarction and deep vein thrombosis. Fourteen cases of EGPA diagnosed at the Department of Dermatology in Asahikawa Medical University from 1977 to 2017 were clinically and histopathologically reviewed. In 6 (43%) cases, skin lesions were the initial manifestation of EGPA. Among the cutaneous lesions, purpura and erythema were the most common. Persistent proteinuria and macrohematuria were observed in only 2 myeloperoxidase-antineutrophil cytoplasmic antibody-positive cases. Systemic thrombotic symptoms, such as cerebral infarction and deep vein thrombosis, were detected in 5 (36%) cases, and, in 3 of those cases, thromboses in dermal or subcutaneous vessels were observed histopathologically. Elevation of plasma D-dimer level (>2.5 μg/mL) was significantly correlated with concomitant systemic thrombotic symptoms (P = 0.0152, Fischer exact test). The histopathological finding of thrombotic features and increased plasma D-dimer were predictive factors of EGPA accompanied with systemic thromboses, such as deep vein thromboses and cerebral infarction.

    DOI： 10.1097/DAD.0000000000001202

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  • Drug-induced hypersensitivity syndrome followed by chronic inflammatory demyelinating polyneuropathy. International journal

    Shin Iinuma, Kyoko Kanno, Masaru Honma, Motoshi Kinouchi, Akemi Ishida-Yamamoto

    The Journal of dermatology   45 ( 11 )   e310-e311   2018.11

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  • Cutaneous hydrophilic polymer embolism accompanied by acute renal failure. International journal

    Kenta Sasaki, Shin Iinuma, Tomoe Nakagawa, Kyoko Kanno, Masaru Honma, Yuya Kitani, Akemi Ishida-Yamamoto

    The Journal of dermatology   45 ( 10 )   e274-e275   2018.10

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  • Severe thiopurine-induced leukocytopenia and hair loss in Japanese patients with defective NUDT15 variant: Retrospective case-control study. International journal

    Mari Kishibe, Hiroyoshi Nozaki, Mizue Fujii, Shin Iinuma, Sawa Ohtsubo, Satomi Igawa, Kyoko Kanno, Masaru Honma, Kan Kishibe, Kensaku Okamoto, Akemi Ishida-Yamamoto

    The Journal of dermatology   45 ( 10 )   1160 - 1165   2018.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    Azathioprine (AZA)-metabolizing enzyme gene polymorphism is strongly related to thiopurine-induced leukocytopenia, which has not been well recognized in dermatological practice. We tried to see whether NUDT15 gene polymorphism can be the most susceptible genetic factor for AZA toxicity and the gene screening is beneficial to avoid the adverse events of AZA for the treatment of skin diseases. A retrospective study was carried out on 15 adult Japanese patients who were treated with AZA. Gene polymorphism of thiopurine-metabolizing enzymes NUDT15 R139C, ITPA 94C>A, TPMT*2, TPMT*3B and TPMT*3C was analyzed. The single nucleotide polymorphisms were prospectively investigated in eight patients who were considered to have received AZA treatments. Two NUDT15 R139C homozygous patients developed agranulocytosis, severe thrombocytopenia and massive hair loss. The gene screening prior to AZA treatment identified one heterozygote of NUDT15 R139C and ITPA 94C>A, and three heterozygotes of ITPA 94C>A or TMPT*3C. Although this study was a retrospective single-center case-control observational study that enrolled a small number of patients, NUDT15 R139C homozygosity is a genetic risk of thiopurine-induced potentially fetal hematological abnormalities. To avoid serious adverse events, gene screening of thiopurine-metabolizing enzymes, at least NUDT15 R139C, should be considered prior to administration in genetically predisposed populations, such as Japanese. We highlight that massive hair loss in the early period of the initiation of AZA would be a sign of impending severe myelotoxicity.

    DOI： 10.1111/1346-8138.14588

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  • Novel PSTPIP1 gene mutation in pyoderma gangrenosum, acne and suppurative hidradenitis syndrome. International journal

    Nao Saito, Masako Minami-Hori, Hiroko Nagahata, Hiroyoshi Nozaki, Shin Iinuma, Satomi Igawa, Kyoko Kanno, Mari Kishibe, Nobuo Kanazawa, Akemi Ishida-Yamamoto

    The Journal of dermatology   45 ( 8 )   e213-e214   2018.8

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  • Extensive auricular necroses as an initial symptom of cryofibrinogenemia occurring secondary to gastric diffuse large B-cell lymphoma. International journal

    Takeshi Iwasaki, Hiroyoshi Nozaki, Takefumi Saito, Satomi Igawa, Kyoko Kanno, Mari Kishibe, Masako Minami-Hori, Masaru Honma, Satoshi Ito, Akemi Ishida-Yamamoto

    The Journal of dermatology   44 ( 10 )   e258-e259   2017.10

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  • Serum carcinoembryonic antigen specifically increases among various serum markers of adenocarcinoma in hypohidrosis or conditions related to hypohidrosis. International journal

    Masaru Honma, Hiroyoshi Nozaki, Hiroko Nagahata, Mizue Fujii, Takashi Shibuya, Kyoko Kanno, Masako Minami-Hori, Akemi Ishida-Yamamoto

    The Journal of dermatology   44 ( 8 )   903 - 908   2017.8

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    Anhidrosis/hypohidrosis are conditions presenting various level of sweating dysfunction. Among them, acquired idiopathic generalized anhidrosis (AIGA) presents inadequate decrease or loss of sweating without apparent neurological and dermatological symptoms except cholinergic urticaria. Recently, serum level of carcinoembryonic antigen (CEA), one of the most well-known tumor markers, has been proposed as a clinical marker reflecting activity of AIGA. This study was performed to verify the specificity and independence of serum CEA level from the other serum tumor markers especially related to adenocarcinoma. The expression of various tumor markers in the serum collected from three healthy control subjects, four AIGA cases, and a cholinergic urticaria (CU) case with elevation of serum CEA level and history of hyperthermia was analyzed using a membrane-based antibody array. In all AIGA and CU cases, the intensity of CEA was significantly increased (7.60-15.9 times compared with that of control), relatively well-reflecting the serum CEA level, and the mean intensity of CEA was 11.8 times higher than the control subjects (P = 0.0011). On the other hand, the ratio of carbohydrate antigen (CA)125 and CA19-9 was 1.93 and 0.23 times compared with the mean intensity of the control subjects, respectively, and there was no statistical significance. Immunohistochemistry on 10 AIGA cases showed increased expression of CEA but not CA19-9 and CA125 in the eccrine sweat glands. In conclusion, the elevation of serum CEA level was independent from the other tumor markers in hypohidrotic condition represented by AIGA.

    DOI： 10.1111/1346-8138.13828

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  • Cutaneous adverse reaction of mogamulizumab, an anti-CC chemokine receptor 4 monoclonal antibody: Shared histopathological features with thymoma-associated multi-organ autoimmunity. International journal

    Kyoko Kanno, Masaru Honma, Akemi Ishida-Yamamoto

    The Journal of dermatology   44 ( 6 )   e117-e118   2017.6

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  • Anticentriole antibody-positive limited cutaneous systemic sclerosis. International journal

    Hiroyoshi Nozaki, Mari Kishibe, Kyoko Kanno, Satomi Igawa, Takefumi Saito, Tomoe Shimamura, Masako Minami-Hori, Masaru Honma, Akemi Ishida-Yamamoto

    The Journal of dermatology   44 ( 6 )   e119-e120   2017.6

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  • Elevation of serum carcinoembryonic antigen in a case of cholinergic urticaria with failed detection of hypohidrosis by the conventional starch-iodine test. International journal

    Masaru Honma, Hiroyoshi Nozaki, Hiroko Nagahata, Mizue Fujii, Kyoko Kanno, Masako Minami-Hori, Akemi Ishida-Yamamoto

    The Journal of dermatology   44 ( 3 )   e38-e39   2017.3

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  • Serum carcinoembryonic antigen (CEA) as a clinical marker in acquired idiopathic generalized anhidrosis: a close correlation between serum CEA level and disease activity. International journal

    M Honma, S Iinuma, K Kanno, S Komatsu, M Minami-Hori, H Iizuka, A Ishida-Yamamoto

    Journal of the European Academy of Dermatology and Venereology : JEADV   30 ( 8 )   1379 - 83   2016.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Hypohidrosis/anhidrosis are congenital or acquired sweating impairments. Among them, acquired idiopathic generalized anhidrosis/hypohidrosis (AIGA) is the most common, and characterized by favourable response to systemic corticosteroid, however, no clinical markers for disease severity or activity have been developed. OBJECTIVE: Our aim was to verify the usefulness of serum carcinoembryonic antigen (CEA) level monitoring as a clinical marker for disease activity of AIGA. METHODS: Ten cases of AIGA diagnosed at Asahikawa Medical University, from 1980 to 2014 were included in the study. CEA and/or CEACAM1 expression level was analysed using immunohistochemistry and enzyme-linked immunosorbent assay. RESULT: CEA expression was restricted to the apical membrane of glandular cells in eccrine sweat glands in most of the three types of cases we examined [healthy control, patients with atopic dermatitis (AD) or urticaria]. However, CEA expression was detected diffusely and much more intensively in eight of the 10 AIGA cases included in this study. CEACAM1-expression was much more restricted on the apical membrane of glandular cells of both the AIGA cases and the other control subjects. While serum CEA levels increased in all five AIGA cases examined (5.8-43.2 ng/mL), it remained within normal limits in all control subjects: nine healthy individuals; 10 cases of AD; 10 cases of idiopathic urticaria; four cases of normohidrotic cholinergic urticaria (Mann-Whitney's U-test, P < 0.05). The increased serum CEA levels in AIGA decreased in conjunction with improved sweating during methyl prednisolone pulse therapy or repeated bathing. CONCLUSION: Serum CEA level may serve as a clinical marker for AIGA activity.

    DOI： 10.1111/jdv.13390

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  • Correlation of disease activity and serum level of carcinoembryonic antigen in acquired idiopathic generalized anhidrosis: A case report. International journal

    Masaru Honma, Shin Iinuma, Kyoko Kanno, Shigetsuna Komatsu, Masako Minami-Hori, Akemi Ishida-Yamamoto

    The Journal of dermatology   42 ( 9 )   900 - 2   2015.9

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    Hypohidrosis and anhidrosis are congenital or acquired conditions which are characterized by inadequate sweating. Acquired idiopathic generalized hypohidrosis/anhidrosis (AIGA) includes idiopathic pure sudomotor failure (IPSF), which has the following distinct features: sudden onset in youth, increased serum immunoglobulin E and responds favorably to systemic corticosteroid. No clinical markers reflecting the disease severity or activity have been established. Here, we report a case of AIGA in a Japanese patient successfully treated with repeated methylprednisolone pulse therapy. In this case, serum carcinoembryonic antigen (CEA) levels increased up to 19.8 ng/mL along with aberrant CEA immunoreactivity of eccrine sweat glands. Interestingly, the serum CEA level normalized as sweating improved with repeated methylprednisolone pulse therapy. Therefore, serum CEA level may serve as a useful clinical marker of hypohidrosis or anhidrosis.

    DOI： 10.1111/1346-8138.12926

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  • Cutaneous lesions of Kikuchi's disease: evolution of histopathological findings. International journal

    Kyoko Kanno, Masako Minami-Hori, Akemi Ishida-Yamamoto, Keiji Komura, Kensuke Oikawa, Naoyuki Miyokawa, Hajime Iizuka

    The Journal of dermatology   41 ( 8 )   736 - 8   2014.8

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    We report a 38-year-old male patient who presented with cutaneous lesions mimicking widespread discoid lupus erythematosus with high-grade fever, arthralgia and lymphadenopathy. Additional lymph node and skin biopsies, however, revealed karyorrhectic debris without neutrophils and numerous CD68-positive cells, a characteristic finding of Kikuchi's disease (KD). Comparing skin biopsies on different occasions, we could see different forms of histopathology. The histopathology of skin lesions of KD may vary during the clinical course, which may reflect the stage of the disease.

    DOI： 10.1111/1346-8138.12557

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  • Drug-induced hypersensitivity syndrome due to minocycline complicated by severe myocarditis. International journal

    Kyoko Kanno, Hiroyuki Sakai, Yutaka Yamada, Hajime Iizuka

    The Journal of dermatology   41 ( 2 )   160 - 2   2014.2

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    A 60-year-old woman presented with a 13-day history of a generalized erythematous rash accompanied by fever, periorbital edema and axillary lymphadenopathy. Prior to the appearance of the rash, the patient had been treated with intermittent courses of oral minocycline for cystitis. The patient was diagnosed with drug-induced hypersensitivity syndrome (DIHS) due to minocycline. During the admission, infectious endocarditis was suspected and the patient was treated with i.v. gammaglobulin (0.4 g/kg per day). The following day, the patient suffered from systemic deterioration and symptomatic low blood pressure that prompted repeat echocardiography which revealed an ejection fraction of 10%. DIHS-associated myocarditis was suspected and management with circulation assistance devices and steroid pulse therapy were started, resulting in satisfactory resolution. A rise in titer of human herpesvirus-6, cytomegalovirus and Herpes simplex virus-1 antibodies was detected. Although minocycline-induced myocarditis is rare, this severe drug reaction should be considered with DIHS.

    DOI： 10.1111/1346-8138.12378

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  • Developmental alterations of physical properties and components of neonatal-infantile stratum corneum of upper thighs and diaper-covered buttocks during the 1st year of life. International journal

    Masako Minami-Hori, Masaru Honma, Mizue Fujii, Wakana Nomura, Kyoko Kanno, Tokinaka Hayashi, Eiki Nakamura, Ken Nagaya, Yuki Miyauchi, Tsutomu Fujimura, Mitsuyuki Hotta, Yutaka Takagi, Takashi Kitahara, Yoshinori Takema, Hajime Iizuka

    Journal of dermatological science   73 ( 1 )   67 - 73   2014.1

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    BACKGROUND: Although physical properties of neonatal-infantile stratum corneum (SC) change drastically after birth, precise developmental alterations of specific sites have not been fully elucidated. OBJECTIVE: To determine the longitudinal alterations of neonatal-infantile SC functions and components of upper thighs and diaper-covered buttocks during the first year of life. The data were compared with those of adults. METHODS: Nineteen full-term neonates and their mothers were subjected to the measurements. Skin hydration, water sorption/retention capacity, TEWL were measured. Superficial SC analyses for NMF, ester binding sebum, and free fatty acids were performed by ATR-FTIR spectrometer. Total amount of ceramides (CERs) and CER subclasses were analyzed by NPLC-ESI-MS. RESULTS: SC hydration of neonatal thighs was lower than that of their mothers, which rapidly increased during the 1st month. Skin hydration of neonatal buttocks was similar to that of their mothers. This also rapidly increased during the 1st month. The neonatal TEWL was less than those of their mothers indicating more efficient barrier function at both sites, which significantly increased during the 1st year development. This was mostly correlated decreased in the ω-hydroxy fatty acid-esterified CERs. Superficial ester-binding sebum content of neonates was similar to that of their mothers, which significantly decreased during the measurement; the decrease was more marked on buttocks. Neither NMF nor FFA of the superficial SC showed significant alteration during the 1-year development. CONCLUSION: Our results indicate that physical functions and components of neonatal-infantile SC show considerable alterations between diaper-covered buttocks and upper thighs during the 1st year development.

    DOI： 10.1016/j.jdermsci.2013.08.015

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  • An adult case of kawasaki disease in a pregnant Japanese woman: a case report. International journal

    Kyoko Kanno, Hiroyuki Sakai, Masahide Nakajima, Akira Satake, Takayuki Konishi, Hajime Iizuka

    Case reports in dermatology   3 ( 1 )   98 - 102   2011.4

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    Kawasaki disease is an acute febrile disease predominantly seen in young children. We report a case of Kawasaki disease in a 32-year-old pregnant woman. She developed a generalized erythematous skin rash accompanied by high fever. Bilateral conjunctival congestion, tender cervical lymphadenopathy, an edematous lower lip and peripheral edema followed by desquamation were observed. She was successfully treated with aspirin and intravenous gammaglobulin (1 g/kg/day). Her course was not complicated by coronary artery aneurysm and she delivered a healthy baby. To the best of our knowledge, this is the first case of Kawasaki disease in a pregnant woman. We suggest that Kawasaki disease should be included in the differential diagnosis of a generalized, erythematous skin rash accompanied by high fever in adults.

    DOI： 10.1159/000327937

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  • TODAY’S THERAPY

    （ Role： Joint authorpernio）

    2026.2 

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  • １冊でわかる皮膚病理 第2版

    （ Role： Joint author結節性紅斑 硬化性脂肪織炎 脂肪萎縮症）

    文光堂  2025.4 

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  • WHAT'S NEW in皮膚科学2022-2023

    菅野恭子（ Role： Joint authorWong-type dermatomyositis~皮疹の意義について～）

    メディカルビュー社  2022.3 

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  • TODAY’S THERAPY

    Kyoko Kanno（ Role： Joint authorpernio）

    igakusyoin  2022.1 

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  • hifubyourinosubeteⅡ

    （ Role： Joint authorBallooning vesicular dermatitis, superficial and deep）

    2020.10 

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  • Color Atlas of Dermatology

    （ Role： Joint authorpretibial myxedema）

    2011.11 

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MISC

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Presentations

  • The Power of Coding in Medical Practice Invited

    Kyoko Kanno

    2025.12 

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    Event date： 2025.12

    Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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  • 旭川医科大学病院二輪草センター（復職・子育て・介護支援センター）の取り組み Invited

    菅野恭子

    日本呼吸器学会北海道支部学術集会  2024.2 

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    Event date： 2024.2

    Language：Japanese  

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