2025/05/29 更新

写真a

カンノ　キヨウコ
菅野　恭子
KAN-NO Kyoko
所属
学内共同利用施設 復職・子育て・介護支援センター
外部リンク

論文

  • 小児の下顎に生じたLipofibromatosisの1例 招待 査読

    菅野恭子

    日本小児皮膚科学会誌   44 ( 2 )   2025年6月

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    担当区分：筆頭著者   記述言語：日本語  

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  • Autoimmunity-related neutrophilic dermatosis after coronavirus disease 2019 vaccination: A case report and literature review 査読

    Mari Kishibe, Katuya Koike, Kyoko Kanno, Akemi Ishida Yamamoto

    Journal of Dermatology   50 ( 6 )   820 - 823   2023年6月

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    担当区分：責任著者  

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  • A case of erythema elevatum diutinum with pyoderma gangrenosum 査読

    Australas J Dermatol   64 ( 2 )   288 - 291   2023年3月

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    担当区分：最終著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

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  • 病理と臨床 招待 査読

    菅野恭子

    脂肪織の変化 Panniculitis   40 ( 7 )   685 - 689   2022年7月

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    担当区分：筆頭著者   記述言語：日本語  

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  • Inclusion bodies are not uncommon in angioleiomyoma 査読

    Mari Kishibe, Satomi Igawa, Kyoko Kanno, Akemi Ishida-Yamamoto

    Journao of cutaneous pathology   48 ( 2 )   269 - 273   2021年2月

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    担当区分：責任著者  

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  • Increased Circulating Cell-Free DNA in Eosinophilic Granulomatosis With Polyangiitis: Implications for Eosinophil Extracellular Traps and Immunothrombosis. 国際誌

    Teppei Hashimoto, Shigeharu Ueki, Yosuke Kamide, Yui Miyabe, Mineyo Fukuchi, Yuichi Yokoyama, Tetsuya Furukawa, Naoto Azuma, Nobuyuki Oka, Hiroki Takeuchi, Kyoko Kanno, Akemi Ishida-Yamamoto, Masami Taniguchi, Akira Hashiramoto, Kiyoshi Matsui

    Frontiers in immunology   12   801897 - 801897   2021年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    BACKGROUND: Endogenous DNA derived from nuclei or mitochondria is released into the blood circulation as cell-free DNA (cfDNA) following cell damage or death. cfDNA is associated with various pathological conditions; however, its clinical significance in antineutrophil cytoplasmic antibody-associated vasculitis (AAV) remains unclear. This study aimed to evaluate the clinical significance of cfDNA in AAV. METHODS: We enrolled 35 patients with AAV, including 10 with eosinophilic granulomatosis with polyangiitis (EGPA), 13 with microscopic polyangiitis, and 12 with granulomatosis with polyangiitis. Serum cf-nuclear DNA (cf-nDNA) and cf-mitochondrial DNA (cf-mtDNA) levels were measured by quantitative polymerase chain reaction before and after the initiation of immunosuppressive therapy. Tissue samples from EGPA patients were examined by immunofluorescence and transmission electron microscopy. The structure of eosinophil extracellular traps (EETs) and neutrophil extracellular traps (NETs) and stability against DNase were assessed in vitro. Platelet adhesion of EETs were also assessed. RESULTS: Serum cf-nDNA and cf-mtDNA levels were significantly higher in AAV than in healthy controls, with the highest levels in EGPA; however, serum DNase activities were comparable among all groups. cf-nDNA and cf-mtDNA decreased after treatment and were associated with disease activity only in EGPA. Blood eosinophil count and plasma D-dimer levels were significantly correlated with cf-nDNA in EGPA and cf-mtDNA. EGPA tissue samples showed lytic eosinophils and EETs in small-vessel thrombi. The structure of EETs showed bolder net-like chromatin threads in vitro and EETs showed greater stability against DNase than NETs. EETs provided a scaffold for platelet adhesion. CONCLUSION: cfDNA was increased in EGPA, associated with disease activity. The presence of DNase-resistant EETs in small-vessel thrombi might contribute to higher concentration of cfDNA and the occurrence of immunothrombosis in EGPA.

    DOI： 10.3389/fimmu.2021.801897

    PubMed

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  • Dermoscopy of Bier spots 査読

    Kenta Sasaki, Shin Iinuma, Naoki Tsuruta, Kyoko Kanno, Mari Kishibe, Masaru Honma, Akemi Ishida-Yamamoto

    European Journal of Dermatology   30 ( 3 )   300 - 301   2020年6月

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    担当区分：責任著者  

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  • Radiation recall dermatitis induced by mogamulizumab 査読

    K Sasaki, S Iinuma, M Fuji, T Shibuya, K Kanno, M Honma Hatayama, A Ishida-Yamamoto

    J Eur Acad Dermatol Venereol   34 ( 2 )   107 - 108   2020年2月

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    担当区分：責任著者  

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  • Histopathological Findings and Increased D-Dimer Are Predictive Factors of Systemic Thromboses in Eosinophilic Granulomatosis With Polyangiitis. 国際誌

    Kyoko Kanno, Masako Minami-Hori, Masaru Honma, Akemi Ishida-Yamamoto

    The American Journal of dermatopathology   40 ( 12 )   879 - 883   2018年12月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Eosinophilic granulomatosis with polyangiitis (EGPA; ie, Churg-Strauss syndrome) is one of the antineutrophil cytoplasmic antibody-associated vasculitis syndromes. Although extravascular granulomatoses are a well-known histopathological feature, the diverse histopathologic spectrum of cutaneous lesions has not been described in detail. Thus, this study sought to investigate the possible correlation between the clinical features and histopathology of cutaneous lesions in EGPA cases, focusing on systemic thrombogenic conditions, such as visceral infarction and deep vein thrombosis. Fourteen cases of EGPA diagnosed at the Department of Dermatology in Asahikawa Medical University from 1977 to 2017 were clinically and histopathologically reviewed. In 6 (43%) cases, skin lesions were the initial manifestation of EGPA. Among the cutaneous lesions, purpura and erythema were the most common. Persistent proteinuria and macrohematuria were observed in only 2 myeloperoxidase-antineutrophil cytoplasmic antibody-positive cases. Systemic thrombotic symptoms, such as cerebral infarction and deep vein thrombosis, were detected in 5 (36%) cases, and, in 3 of those cases, thromboses in dermal or subcutaneous vessels were observed histopathologically. Elevation of plasma D-dimer level (>2.5 μg/mL) was significantly correlated with concomitant systemic thrombotic symptoms (P = 0.0152, Fischer exact test). The histopathological finding of thrombotic features and increased plasma D-dimer were predictive factors of EGPA accompanied with systemic thromboses, such as deep vein thromboses and cerebral infarction.

    DOI： 10.1097/DAD.0000000000001202

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  • Cutaneous adverse reaction of mogamulizumab, an anti-CC chemokine receptor 4 monoclonal antibody: Shared histopathological features with thymoma-associated multi-organ autoimmunity. 国際誌

    Kyoko Kanno, Masaru Honma, Akemi Ishida-Yamamoto

    The Journal of dermatology   44 ( 6 )   e117-e118   2017年6月

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  • Cutaneous lesions of Kikuchi's disease: evolution of histopathological findings. 国際誌

    Kyoko Kanno, Masako Minami-Hori, Akemi Ishida-Yamamoto, Keiji Komura, Kensuke Oikawa, Naoyuki Miyokawa, Hajime Iizuka

    The Journal of dermatology   41 ( 8 )   736 - 8   2014年8月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    We report a 38-year-old male patient who presented with cutaneous lesions mimicking widespread discoid lupus erythematosus with high-grade fever, arthralgia and lymphadenopathy. Additional lymph node and skin biopsies, however, revealed karyorrhectic debris without neutrophils and numerous CD68-positive cells, a characteristic finding of Kikuchi's disease (KD). Comparing skin biopsies on different occasions, we could see different forms of histopathology. The histopathology of skin lesions of KD may vary during the clinical course, which may reflect the stage of the disease.

    DOI： 10.1111/1346-8138.12557

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  • Drug-induced hypersensitivity syndrome due to minocycline complicated by severe myocarditis. 国際誌

    Kyoko Kanno, Hiroyuki Sakai, Yutaka Yamada, Hajime Iizuka

    The Journal of dermatology   41 ( 2 )   160 - 2   2014年2月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    A 60-year-old woman presented with a 13-day history of a generalized erythematous rash accompanied by fever, periorbital edema and axillary lymphadenopathy. Prior to the appearance of the rash, the patient had been treated with intermittent courses of oral minocycline for cystitis. The patient was diagnosed with drug-induced hypersensitivity syndrome (DIHS) due to minocycline. During the admission, infectious endocarditis was suspected and the patient was treated with i.v. gammaglobulin (0.4 g/kg per day). The following day, the patient suffered from systemic deterioration and symptomatic low blood pressure that prompted repeat echocardiography which revealed an ejection fraction of 10%. DIHS-associated myocarditis was suspected and management with circulation assistance devices and steroid pulse therapy were started, resulting in satisfactory resolution. A rise in titer of human herpesvirus-6, cytomegalovirus and Herpes simplex virus-1 antibodies was detected. Although minocycline-induced myocarditis is rare, this severe drug reaction should be considered with DIHS.

    DOI： 10.1111/1346-8138.12378

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  • An adult case of kawasaki disease in a pregnant Japanese woman: a case report. 国際誌

    Kyoko Kanno, Hiroyuki Sakai, Masahide Nakajima, Akira Satake, Takayuki Konishi, Hajime Iizuka

    Case reports in dermatology   3 ( 1 )   98 - 102   2011年4月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Kawasaki disease is an acute febrile disease predominantly seen in young children. We report a case of Kawasaki disease in a 32-year-old pregnant woman. She developed a generalized erythematous skin rash accompanied by high fever. Bilateral conjunctival congestion, tender cervical lymphadenopathy, an edematous lower lip and peripheral edema followed by desquamation were observed. She was successfully treated with aspirin and intravenous gammaglobulin (1 g/kg/day). Her course was not complicated by coronary artery aneurysm and she delivered a healthy baby. To the best of our knowledge, this is the first case of Kawasaki disease in a pregnant woman. We suggest that Kawasaki disease should be included in the differential diagnosis of a generalized, erythematous skin rash accompanied by high fever in adults.

    DOI： 10.1159/000327937

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書籍等出版物

  • １冊でわかる皮膚病理 第2版

    （ 担当： 共著 範囲: 結節性紅斑 硬化性脂肪織炎 脂肪萎縮症）

    文光堂  2025年4月 

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  • WHAT'S NEW in皮膚科学2022-2023

    菅野恭子（ 担当： 共著 範囲: Wong-type dermatomyositis~皮疹の意義について～）

    メディカルビュー社  2022年3月 

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  • 今日の治療指針

    菅野恭子（ 担当： 共著 範囲: 凍瘡）

    医学書院  2022年1月 

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  • 皮膚病理のすべてⅡ

    菅野恭子（ 担当： 共著）

    文光堂  2020年10月 

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  • 皮膚科診療カラーアトラス体系

    菅野恭子（ 担当： 共著 範囲: 脛骨前粘液水腫）

    講談社  2011年11月 

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MISC

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講演・口頭発表等

  • 旭川医科大学病院二輪草センター（復職・子育て・介護支援センター）の取り組み 招待

    菅野恭子

    日本呼吸器学会北海道支部学術集会  2024年2月 

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    開催年月日： 2024年2月

    記述言語：日本語  

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