Updated on 2025/04/02

写真a

 
MANABE Takayuki
 
Organization
Hospital Central Clinical Facilities Clinical Research Support Center
External link

Degree

  • 博士（薬学） ( 2013.3   摂南大学 )

Research Interests

  • LPS(endotoxin)

  • Innate immunity

  • antimicrobial peptide

  • 神経変性疾患

  • パーキンソン病

Research Areas

  • Life Science / Pharmacology

  • Life Science / Clinical pharmacy

  • Life Science / Pharmaceutical hygiene and biochemistry

  • Life Science / Molecular biology

Education

  • Setsunan University   Graduate School of Pharmaceutical Sciences

    2004.4 - 2006.3

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    Country： Japan

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  • Setsunan University   Faculty of Pharmaceutical Sciences

    2000.4 - 2004.3

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    Country： Japan

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Research History

  • Asahikawa Medical College   Department of Nursing   Associate Professor

    2024.10

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  • 旭川医科大学病院   臨床研究支援センター   講師（学内）

    2024.4 - 2024.9

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  • Asahikawa Medical University   clinical reserch support center   Assistant Professor

    2018.4 - 2024.9

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  • Asahikawa Medical College   Research Assistant

    2017.4 - 2018.3

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  • Doshisha Women's College of Liberal Arts   Faculty of Pharmaceutical Sciences Department of Clinical Pharmacy

    2014.4 - 2017.3

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  • Doshisha Women's College of Liberal Arts   Faculty of Pharmaceutical Sciences Department of Clinical Pharmacy

    2007.7 - 2014.3

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  • Doshisha Women's College of Liberal Arts   Faculty of Pharmaceutical Sciences

    2006.4 - 2007.6

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Professional Memberships

Papers

  • The Effect of Concomitant Usage of Analgesics on Immune Checkpoint Inhibitor-related Interstitial Lung Disease. Reviewed International journal

    Takayuki Manabe, Kuninori Iwayama, Masayuki Chuma, Yoshikazu Tasaki, Seiji Matsumoto

    In vivo   37 ( 3 )   1260 - 1265   2023.5

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND/AIM: Interstitial lung disease (ILD) is a serious adverse event (AE) associated with the use of immune checkpoint inhibitors (ICIs). However, the risk factors for developing ICI-related ILD remain poorly understood. Therefore, this study investigated the effect of concomitant analgesics on developing ICI-related ILD using the Japanese Adverse Drug Event Report (JADER) database. PATIENTS AND METHODS: All the reported AE data were downloaded from the Pharmaceuticals and Medical Devices Agency website, and the JADER data between January 2014 and March 2021 were analysed. The relationship between ICI-related ILD and concomitant use of analgesics was assessed using reporting odds ratio (ROR) and 95% confidence interval. We investigated whether the effect of developing ILD varied according to the type of analgesics used during ICI treatment. RESULTS: Positive signals for ICI-related ILD development were detected for the concomitant use of the narcotic analgesics codeine, fentanyl and oxycodone, but not with morphine. In contrast, there were no positive signals for the concomitant use of the non-narcotic analgesics celecoxib, acetaminophen, loxoprofen and tramadol. An increased ROR for ICI-related ILD in cases with concomitant use of narcotic analgesics was observed in a multivariate logistic analysis adjusted by sex and age. CONCLUSION: These results suggest that the concomitant use of narcotic analgesics is involved in the development of ICI-related ILD.

    DOI： 10.21873/invivo.13203

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  • Efforts to Optimize Clinical Trial Management by Revising Deviation Reports and Classifying Deviation Cases for Efficient Clinical Trial Quality Improvement at Asahikawa Medical University Hospital Reviewed

    小川真澄, 眞鍋貴行, 近藤夕子, 畑山幸恵, 谷香苗, 佐藤幸, 横山真利子, 結城和美, 神山直也, 本間大, 田崎嘉一, 松本成史

    臨床薬理   54 ( 2 )   71 - 75   2023.3

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    Authorship：Corresponding author   Language：Japanese   Publisher：Japanese Society of Clinical Pharmacology and Therapeutics  

    DOI： 10.3999/jscpt.54.2_71

    J-GLOBAL

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  • Effect of charged-cluster distribution of the ZIF268 zinc finger surface on cell membrane permeability Reviewed

    Shigeru Negi, Mami Hamori, Yuka Kawahara-Nakagawa, Masato Mashimo, Miki Imanishi, Nozomi Kuki, Yuri Kawahito, Takayuki Manabe, Nobuyuki Kawamura, Jyunichiro Yasukawa, Hiroaki Kitagishi, Yukio Sugiura

    Chemistry Letters   52 ( 2 )   75 - 78   2023.2

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：The Chemical Society of Japan  

    DOI： 10.1246/cl.220464

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  • Promotion of Appropriate Use of Recombinant Thrombomodulin and Improvement of Infectious DIC Withdrawal Rate by Intervention of the Ward Pharmacist Reviewed

    山田峻史, 眞鍋貴行, 眞鍋貴行, 丹保亜希仁, 菅谷香緒里, 田原克寿, 田原克寿, 山下恭範, 中馬真幸, 田崎嘉一

    医療薬学   48 ( 11 )   481 - 490   2022.11

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    Language：Japanese  

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  • Transpeptidation Reaction Mediated by Ligand- and Metal Cofactor-Substituted Sortase A from <i>Staphylococcus aureus</i> Reviewed

    Shigeru Negi, Mami Hamori, Ayaka Sato, Kyoko Shimizu, Yuka Kawahara-Nakagawa, Takayuki Manabe, Nobuhito Shibata, Hiroaki Kitagishi, Masato Mashimo, Yukio Sugiura

    Bulletin of the Chemical Society of Japan   95 ( 7 )   1025 - 1031   2022.7

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：The Chemical Society of Japan  

    Sortase A is used for the post-translational modification of proteins in vitro and in cell, and it is known that amino acid residues involved in Ca2+ binding are important for the enzymatic reaction. In this study, the effects of various conditions and mutations on the transpeptidase activity of Sortase A were investigated. We also examined the effect of exogenous metal ions on the enzymatic reaction. The results showed that the transpeptidase activity was maintained over a wide range of Ca2+ concentrations and temperatures. Moreover, amino acid residues E108 and N114, possibly involved in Ca2+ binding, were found essential for enzyme activity. Furthermore, the results showed that Lewis basicity, amino acid side chains, and steric effects were closely related to Ca2+ binding and enzyme activity. In contrast to previous results, we found that Mg2+, an ion homologous to Ca2+, reduced the transpeptidase reactivity of Sortase A to a level comparable to that of the apo form. This study provides fundamental insights into the structure and function of Sortase A, which may be useful for the development of artificial functional Sortase A enzymes.

    DOI： 10.1246/bcsj.20220098

    Web of Science

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  • Importance of two-dimensional cation clusters induced by protein folding in intrinsic intracellular membrane permeability Reviewed International journal

    Shigeru Negi, Mami Hamori, Yuka Kawahara-Nakagawa, Miki Imanishi, Miku Kurehara, Chieri Kitada, Yuri Kawahito, Kanae Kishi, Takayuki Manabe, Nobuyuki Kawamura, Hiroaki Kitagishi, Masato Mashimo, Nobuhito Shibata, Yukio Sugiura

    RSC Chemical Biology   3 ( 8 )   1076 - 1084   2022.7

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Royal Society of Chemistry (RSC)  

    Two-dimensional cation clusters formed on the surface of proteins play an important role in their intracellular translocation.

    DOI： 10.1039/d2cb00098a

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  • Is it Possible for the Investigators in Academia to Purchase Manufacturing-specific Drugs for Manufacturing Investigational Drug Themselves in Japan? -Interpretation of the Notice of the Director-general Regarding Article 138 of the Act on Securing Quality, Efficacy, and Safety of Products Including Pharmaceuticals and Medical Devices- Reviewed

    神山直也, 竹原有史, 眞鍋貴行, 田崎嘉一, 松本成史

    臨床薬理   53 ( 2 )   27 - 34   2022.3

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    Language：Japanese  

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  • Antibacterial Treatment of Palmoplantar Pustulosis Shortens Hortens the Response Time and the Lymphocyte/Monocyte Ratio can Serve as a Biomarker of Palmoplantar Pustulosis Reviewed

    岩山訓典, 眞鍋貴行, 岸部麻里, 本間大, 田崎嘉一

    医療薬学   46 ( 10 )   567 - 575   2020.10

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    Language：Japanese  

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  • Pharmacists’ Interventions in the Infection Control Team Reduce Prophylactic Intravenous Antibiotics in Cataract Surgery Reviewed

    吉田光一, 山本譲, 大滝康一, 大滝康一, 都築仁美, 高橋淳士, 寒藤雅俊, 飯田慎也, 笠茂紗千子, 眞鍋貴行, 三嶋一登, 小野尚志, 福土将秀, 粟屋敏雄, 粟屋敏雄, 田崎嘉一

    医療薬学   45 ( 1 )   28 - 33   2019.1

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  • Imidazolines increase the levels of the autophagosomal marker LC3-II in macrophage-like RAW264.7 cells. Reviewed International journal

    Shiori Nakagawa, Takayuki Ueno, Takayuki Manabe, Kiyoshi Kawasaki

    Canadian journal of physiology and pharmacology   96 ( 8 )   845 - 849   2018.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    This study evaluated whether imidazolines can induce autophagy in the murine macrophage-like cell line RAW264.7. Idazoxan increased the content of LC3-II, an autophagosomal marker, in RAW264.7 cells. To determine whether this effect was due to the induction of its synthesis or inhibition of its degradation, idazoxan treatment was performed in the presence of bafilomycin A1, which blocks autophagosome-lysosome fusion, as well as Pepstatin A and E-64d, both of which block protein degradation in autolysosomes. An increased content of LC3-II was observed in the presence of bafilomycin A1 as well as the protease inhibitors. Furthermore, an increased number of autophagosomes was observed following idazoxan treatment using an autophagosome-specific dye. This indicated that idazoxan induced autophagy. Other imidazolines, such as efaroxan, clonidine, and 2-(2-benzofuranyl)-2-imidazoline, also increased the LC3-II content in RAW264.7 cells in the presence of bafilomycin A1. Taken together, these results indicate that some imidazolines, including idazoxan, can induce autophagy in RAW264.7 cells.

    DOI： 10.1139/cjpp-2018-0021

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  • D-form KLKLLLLLKLK-NH2 peptide exerts higher antimicrobial properties than its L-form counterpart via an association with bacterial cell wall components. Reviewed International journal

    Takayuki Manabe, Kiyoshi Kawasaki

    Scientific reports   7   43384 - 43384   2017.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    The antimicrobial peptide KLKLLLLLKLK-NH2 was developed based on sapesin B, and synthesized using D-amino acids. Biochemical properties of the D-form and L-form KLKLLLLLKLK-NH2 peptides were compared. In order to limit the effects due to bacterial resistance to proteolysis, antimicrobial activities of the peptides were evaluated after short-term exposure to bacteria. D-form KLKLLLLLKLK-NH2 exhibited higher antimicrobial activities than L-form KLKLLLLLKLK-NH2 against bacteria, including Staphylococcus aureus and Escherichia coli. In contrast, both the D-form and L-form of other antimicrobial peptides, including Mastoparan M and Temporin A, exhibited similar antimicrobial activities. Both the D-form KLKLLLLLKLK-NH2 and L-form KLKLLLLLKLK-NH2 peptides preferentially disrupted S. aureus-mimetic liposomes over mammalian-mimetic liposomes. Furthermore, the D-form KLKLLLLLKLK-NH2 increased the membrane permeability of S. aureus more than the L-form KLKLLLLLKLK-NH2. Thus suggesting that the enhanced antimicrobial activity of the D-form was likely due to its interaction with bacterial cell wall components. S. aureus peptidoglycan preferentially inhibited the antimicrobial activity of the D-form KLKLLLLLKLK-NH2 relative to the L-form. Furthermore, the D-form KLKLLLLLKLK-NH2 showed higher affinity for S. aureus peptidoglycan than the L-form. Taken together, these results indicate that the D-form KLKLLLLLKLK-NH2 peptide has higher antimicrobial activity than the L-form via a specific association with bacterial cell wall components, including peptidoglycan.

    DOI： 10.1038/srep43384

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  • Flagella proteins contribute to the production of outer membrane vesicles from Escherichia coli W3110. Reviewed International journal

    Takayuki Manabe, Mayu Kato, Takayuki Ueno, Kiyoshi Kawasaki

    Biochemical and biophysical research communications   441 ( 1 )   151 - 6   2013.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    Gram-negative bacteria, including Escherichia coli, release outer membrane vesicles (OMVs) that are derived from the bacterial outer membrane. OMVs contribute to bacterial cell-cell communications and host-microbe interactions by delivering components to locations outside the bacterial cell. In order to explore the molecular machinery involved in OMV biogenesis, the role of a major OMV protein was examined in the production of OMVs from E. coli W3110, which is a widely used standard E. coli K-12 strain. In addition to OmpC and OmpA, which are used as marker proteins for OMVs, an analysis of E. coli W3110 OMVs revealed that they also contain abundant levels of FliC, which is also known as flagellin. A membrane-impermeable biotin-labeling reagent did not label FliC in intact OMVs, but labeled FliC in sonically disrupted OMVs, suggesting that FliC is localized in the lumen of OMV. Compared to the parental strain expressing wild-type fliC, an E. coli strain with a fliC-null mutation produced reduced amounts of OMVs based on both protein and phosphate levels. In addition, an E. coli W3110-derived strain with a null-mutation in flgK, which encodes flagellar hook-associated protein that is essential along with FliC for flagella synthesis, also produced fewer OMVs than the parental strain. Taken together, these results indicate that the ability to form flagella, including the synthesis of flagella proteins, affects the production of E. coli W3110 OMVs.

    DOI： 10.1016/j.bbrc.2013.10.022

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  • Latency of the lipid A deacylase PagL is involved in producing a robust permeation barrier in the outer membrane of Salmonella enterica. Reviewed International journal

    Kiyoshi Kawasaki, Takayuki Manabe

    Journal of bacteriology   192 ( 21 )   5837 - 40   2010.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    Lipid A deacylase PagL, which detoxifies endotoxin, is latent in Salmonella enterica. This study determined the biological significance of this latency. PagL latency was beneficial for bacteria in producing a robust permeation barrier through lipid A modifications under host-mimetic conditions that induced the modification enzymes, including PagL.

    DOI： 10.1128/JB.00758-10

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  • Mutations in the lipid A deacylase PagL which release the enzyme from its latency affect the ability of PagL to interact with lipopolysaccharide in Salmonella enterica serovar Typhimurium. Reviewed International journal

    Takayuki Manabe, Miyuki Kawano, Kiyoshi Kawasaki

    Biochemical and biophysical research communications   396 ( 4 )   812 - 6   2010.6

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    PagL, a lipid A deacylase, is unique in that it is latent in the outer membrane of Salmonella enterica serovar Typhimurium. Several point mutations in the extracellular loops of PagL, which do not affect its enzymatic activity, release it from this latency. Precipitation analysis revealed that latent wild-type PagL associated with lipopolysaccharide, but non-latent PagL mutants did not. In contrast, non-latent PagL mutants preferentially associated with some membrane proteins. Precipitation analysis using inactive PagL mutants demonstrated that membrane lipid A deacylation did not affect association. These results indicate that mutations in the lipid A deacylase PagL which relieve the enzyme from its latency affect the ability of PagL to interact with lipopolysaccharide.

    DOI： 10.1016/j.bbrc.2010.04.153

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  • Salmonella enterica serovar Typhimurium lipopolysaccharide deacylation enhances its intracellular growth within macrophages. Reviewed International journal

    Miyuki Kawano, Takayuki Manabe, Kiyoshi Kawasaki

    FEBS letters   584 ( 1 )   207 - 12   2010.1

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    Modification of lipid A is essential for bacterial adaptation to its host. Salmonella Typhimurium LpxR potentially detoxifies lipid A by 3'-O-deacylation; however, the involvement of deacylation in its adaptation remains unclear. LpxR-dependent 3'-O-deacylation was observed in the stationary phase. When macrophages were infected with stationary phase bacteria, the intracellular growth of the lpxR-null strain was lower than that of the wild-type strain. Furthermore, the expression level of inducible nitric oxide synthase was higher in the cells infected with the lpxR-null strain than in the cells infected with the wild-type strain. These results indicate that lipid A 3'-O-deacylation is beneficial for intracellular growth.

    DOI： 10.1016/j.febslet.2009.11.062

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  • Extracellular loops of lipid A 3-O-deacylase PagL are involved in recognition of aminoarabinose-based membrane modifications in Salmonella enterica serovar typhimurium. Reviewed International journal

    Takayuki Manabe, Kiyoshi Kawasaki

    Journal of bacteriology   190 ( 16 )   5597 - 606   2008.8

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    Salmonella enterica serovar Typhimurium modifies its lipopolysaccharide (LPS), including the lipid A portion, in response to changes in its environment including host tissues. The lipid A 3-O-deacylase PagL, the expression of which is promoted under a host-mimetic environment, exhibits latency in S. enterica; deacylation of lipid A is not usually observed in vivo, despite the expression of the outer membrane protein PagL. In contrast, PagL does not exhibit latency in S. enterica pmrA and pmrE mutants, both of which are deficient in the aminoarabinose-based modification of lipid A, indicating that aminoarabinose-modified LPS species were involved in the latency. In order to analyze the machinery for PagL's repression, we generated PagL mutants in which an amino acid residue located at four extracellular loops was replaced with alanine. Apparent lipid A 3-O deacylation was observed in S. enterica expressing the recombinant mutants PagL(R43A), PagL(R44A), PagL(C85A), and PagL(R135A), but not in S. enterica expressing wild-type PagL, suggesting that the point mutations released PagL from the latency. In addition, mutations at Arg-43, Arg-44, Cys-85, and Arg-135 did not affect lipid A 3-O-deacylase activity in an S. enterica pmrA mutant or in Escherichia coli BL21(DE3). These results, taken together, indicate that specific amino acid residues located at extracellular loops of PagL are involved in the recognition of aminoarabinose-modified LPS. Furthermore, S. enterica expressing the recombinant PagL(R43A) or PagL(R135A) mutant showed apparent growth arrest at 43 degrees C compared with S. enterica expressing wild-type PagL, indicating that the latency of PagL is important for bacterial growth.

    DOI： 10.1128/JB.00587-08

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MISC

  • リピドA脂肪酸修飾を行う外膜酵素の活性調節

    川崎清史, 眞鍋貴行

    エンドトキシン研究   12   2009

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Presentations

  • リンパ球・単球比は、掌蹠膿疱症に対する抗菌薬の治療効果を反映する

    第44回 臨床薬理学会 

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    Event date： 2023.12

    Language：Japanese   Presentation type：Oral presentation (general)  

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  • 小児におけるアルベカシンの体内動態に発熱性好中球減少症が及ぼす影響について

    都築仁美, 中馬真幸, 寺川央一, 寒藤雅俊, 岩山訓典, 山本譲, 久保靖憲, 神山直也, 眞鍋貴行, 田崎嘉一

    第32回 日本医療薬学会年会 

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    Event date： 2022.9

    Language：Japanese   Presentation type：Oral presentation (general)  

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  • Covid-19感染症流行前後でのオンサイトモニタリングと治験逸脱の推移について

    小川真澄, 眞鍋貴行, 近藤夕子, 畑山幸恵, 岩城千晶, 五十嵐恵, 神山直也, 本間大, 田崎嘉一, 松本成史

    第5回日本臨床薬理学会北海道・東北地方会  日本臨床薬理学会

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    Event date： 2022.7

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：北海道  

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  • パーキンソン病治療薬を目指したオキシカムアナログIY104のADME評価及び類縁体合成

    鶴岡航太朗, 高橋恭子, 中村成夫, 熊谷直哉, 増野匡彦, 大久保知子, 眞鍋貴行, 田崎嘉一, 大江知之

    日本薬学会 第142回年会  日本薬学会

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    Event date： 2022.3

    Language：Japanese   Presentation type：Poster presentation  

    Venue：愛知県  

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  • バイアル製剤の分割使用を目指した模擬バイアルを用いた長期無菌性保持条件の検討

    松浦泰寛, 眞鍋貴行, 眞鍋貴行, 新田悠一朗, 石川良太, 仲谷彰規, 久保靖憲, 山本譲, 岩山訓典, 岩山訓典, 神山直也, 神山直也, 中馬真幸, 小野尚志, 田崎嘉一, 田崎嘉一

    日本医療薬学会年会講演要旨集(Web)  2022 

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    Event date： 2022

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  • ADME evaluation and derivatization of the oxicam analogue IY104 for the treatment of Parkinson’s disease.

    鶴岡航太朗, 高橋恭子, 中村成夫, 熊谷直哉, 増野匡彦, 大久保知子, 眞鍋貴行, 田崎嘉一, 大江知之

    日本薬学会年会要旨集(Web)  2022 

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    Event date： 2022

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  • 治験品質の効率的な向上を目指した逸脱報告書の改訂

    小川真澄, 眞鍋貴行, 近藤夕子, 畑山幸恵, 谷香苗, 佐藤幸, 横山真利子, 結城和美, 神山直也, 松本成史

    CRCと臨床試験のあり方を考える会議プログラム・抄録集  2022 

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    Event date： 2022

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  • メロキシカムのMPP+誘導性神経細胞死抑制に関与する分子の探索

    眞鍋貴行, 大久保知子, 岩山訓典, 山本譲, 田崎嘉一

    日本薬学会 第140回年会  日本薬学会

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    Event date： 2020.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：京都  

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  • アカデミアが主体となって行う治験薬製造における製造専用医薬品の購入

    神山直也, 竹原有史, 眞鍋貴行, 神保静夫, 田崎嘉一, 松本成史

    臨床薬理  2020 

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    Event date： 2020

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  • Novel molecules involved in the neuroprotection of meloxicam against MPP<sup>+</sup>-induced neuronal death

    眞鍋貴行, 眞鍋貴行, 大久保知子, 岩山訓典, 岩山訓典, 山本譲, 田崎嘉一, 田崎嘉一

    日本薬学会年会要旨集(Web)  2020 

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    Event date： 2020

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  • 薬局における抗HIV用薬調剤時の副作用確認とお薬手帳活用の問題点

    井上正朝, 眞鍋貴行, 三嶋一登, 福土将秀, 田崎嘉一, 田崎嘉一

    医療薬学フォーラム講演要旨集  2019 

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    Event date： 2019

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  • 患者アンケートによるお薬手帳認識調査及び薬局における抗HIV用薬調剤時の副作用確認とお薬手帳活用の問題点

    井上正朝, 眞鍋貴行, 三嶋一登, 福土将秀, 田崎嘉一, 田崎嘉一

    日本エイズ学会誌  2019 

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    Event date： 2019

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  • エントリー促進ツールとして地域フリーペーパーを活用した結果の報告

    畑山幸恵, 西垣夕子, 小川真澄, 岩山訓典, 岩山訓典, 佐々木妃美, 草野芳枝, 佐藤幸, 眞鍋貴行, 松本成史, 田崎嘉一, 田崎嘉一

    CRCと臨床試験のあり方を考える会議プログラム・抄録集  2019 

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    Event date： 2019

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  • ZIF268亜鉛フィンガータンパク質の内在的細胞膜透過能:二次元カチオンクラスター構造の細胞膜移行効率における重要性

    久木望, 北田千江梨, 眞鍋貴行, 杉浦幸雄, 根木滋

    生体分子科学討論会講演要旨集  2018 

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    Event date： 2018

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  • Sp1亜鉛フィンガータンパク質の内在的な細胞膜透過性におけるフォールディング構造の重要性

    呉原美空, 北田千江梨, 眞鍋貴行, 杉浦幸雄, 根木滋

    生体分子科学討論会講演要旨集  2018 

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    Event date： 2018

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  • 播種性血管内凝固症候群に対するトロンボモデュリンアルファ製剤の使用実績と適正使用

    山田峻史, 丹保亜希仁, 眞鍋貴行, 櫻庭好祐, 小野尚志, 田原克寿, 粟屋敏雄, 田崎嘉一

    日本医療薬学会年会講演要旨集(Web)  2018 

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  • カチオン性ペプチドの細胞内移行メカニズム:塩基性アミノ酸構成比の変化及び配列組み換えの影響

    北田千江梨, 呉原美空, 久木望, 眞鍋貴行, 杉浦幸雄, 根木滋

    生体分子科学討論会講演要旨集  2018 

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  • イミダゾリン化合物によるオートファジー誘導作用の解析

    中川詩織, 眞鍋貴行, 上野貴之, 川崎清史

    日本薬学会年会要旨集(CD-ROM)  2017 

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  • リポ多糖トレランスマクロファージではCD14とCD204に依存したリポ多糖の取り込みが促進される

    西原冴佳, 眞鍋貴行, 川崎清史

    日本生化学会大会(Web)  2017 

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  • トレランス状態にあるマクロファージで見られるリポ多糖の積極的取り込みにクラスAスカベンジャー受容体が関与する

    西原冴佳, 眞鍋貴行, 川崎清史

    日本薬学会年会要旨集(CD-ROM)  2017 

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  • D体アミノ酸で合成した抗菌ペプチドKLKLLLLLKLKはL体型よりもペプチドグリカンやリポ多糖に高親和性を示して高い抗菌活性を持つ

    眞鍋 貴行, 川崎 清史

    日本薬学会（第135回大会）  日本薬学会

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    Event date： 2016.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：横浜  

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  • D-アミノ酸で合成した抗菌ペプチドの抗菌活性に関する研究

    眞鍋貴行, 川崎清史

    日本生化学会大会(Web)  2016 

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    Event date： 2016

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  • イミダゾリン化合物によるオートファジーの誘導

    中川詩織, 上野貴之, 眞鍋貴行, 川崎清史

    日本生化学会大会(Web)  2016 

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  • リポ多糖トレランスマクロファージで過剰発現されたCD14はリポ多糖の積極的取り込みに関与する

    西原冴佳, 上田実加, 眞鍋貴行, 川崎清史

    日本薬学会年会要旨集(CD-ROM)  2016 

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  • D-アミノ酸型抗菌ペプチドKLKLLLLLKLKはL-アミノ酸型よりも細胞壁成分に高親和性である

    眞鍋貴行, 川崎清史

    日本薬学会年会要旨集(CD-ROM)  2016 

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  • D体アミノ酸で合成した抗菌ペプチドKLKLLLLLKLKはL体型よりペプチドグリカンやリポ多糖に高親和性を示す

    眞鍋貴行, 川崎清史

    日本生化学会大会(Web)  2015 

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    Event date： 2015

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  • イダゾキサンによるオートファジー誘導の解析

    中川 詩織, 眞鍋 貴行, 上野 貴之, 川崎 清史

    日本薬学会近畿支部会（第64回大会）  日本薬学会近畿支部会

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    Event date： 2014.10

    Language：Japanese   Presentation type：Poster presentation  

    Venue：京都  

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  • D-アミノ酸で合成した抗菌ペプチドKLKLLLLLKLKはL体型よりペプチドグリカンに高親和性を示す

    眞鍋 貴行, 名取 俊二, 川崎 清史

    日本薬学会（第134回大会）  日本薬学会

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    Event date： 2014.3

    Language：Japanese   Presentation type：Poster presentation  

    Venue：熊本  

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  • D体アミノ酸で合成した抗菌ペプチドKLKLLLLLKLKはL体型よりペプチドグリカンに高親和性を示す

    眞鍋貴行, 名取俊二, 川崎清史

    日本薬学会年会要旨集(CD-ROM)  2014 

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  • 大腸菌W3110株の鞭毛形成は細胞外分泌小胞の分泌を誘導する

    眞鍋貴行, 加藤まゆ, 川崎清史

    日本薬学会年会要旨集(CD-ROM)  2013 

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  • D-アミノ酸で合成された抗菌ペプチドKLKLLLLLKLKはL体型よりもペプチドグリカンと強く作用して高い抗菌活性を示す

    眞鍋貴行, 名取俊二, 川崎清史

    日本生化学会大会(Web)  2013 

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  • 大腸菌W3110株から分泌されるOuter membrane vesicle 構成タンパク質の同定と機能解析

    加藤 まゆ, 眞鍋 貴行, 川崎 清史

    日本薬学会近畿支部会（第62回大会）  日本薬学会近畿支部会

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    Event date： 2012.10

    Language：Japanese   Presentation type：Poster presentation  

    Venue：武庫川  

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  • 大腸菌W3110株の膜小胞形成には鞭毛タンパク質をコードするfliCが重要である

    眞鍋 貴行, 川崎 清史

    日本薬学会（第132回大会）  日本薬学会

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    Event date： 2012.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：札幌  

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  • 大腸菌W3110株のOuter membrane vesicle分泌には鞭毛形成が重要である

    眞鍋貴行, 加藤まゆ, 川崎清史

    日本生化学会大会(Web)  2012 

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  • 大腸菌W3110株の膜小胞形成には鞭毛タンパク質をコードするflicが重要である

    眞鍋貴行, 川崎清氏

    日本薬学会年会要旨集  2012 

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  • サルモネラリポ多糖脱アシル化酵素PagLの活性抑制にはリポ多糖との結合が重要である

    眞鍋 貴行, 川崎 清史

    日本生化学会（第83回大会）  日本生化学会

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    Event date： 2010.12

    Language：Japanese   Presentation type：Poster presentation  

    Venue：神戸  

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  • サルモネラリポ多糖脱アシル化酵素PagLの活性抑制にはリポ多糖との結合が重要である。

    眞鍋貴行, 河野美幸, 川崎清史

    生化学  2010 

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  • 二成分制御系PhoP-PhoQ活性化によるサルモネラ外膜透過性障壁の強化に外膜脱アシル化酵素の潜伏性が関与する

    川崎清史, 眞鍋貴行

    生化学  2010 

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  • サルモネラ外膜リパーゼ(PagL)の潜伏性に関わるアミノ酸残基の解析

    川崎清史, 眞鍋貴行

    脂質生化学研究  2010 

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    Event date： 2010

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  • LpxRによるリピドA脱アシル化はサルモネラの効率的な細胞内増殖に必要である

    河野美幸, 眞鍋貴行, 川崎清史

    生化学  2009 

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  • サルモネラLPS脱アシル化酵素PagLの活性調節に関与するアミノ酸残基は他の外膜タンパク質との相互作用に重要である

    眞鍋貴行, 河野美幸, 川崎清史

    生化学  2009 

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  • 細菌外膜脱アシル化酵素の膜表面電荷による活性調節

    川崎清史, 眞鍋貴行, 河野美幸

    日本薬学会年会要旨集  2009 

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  • サルモネラ菌のLPS脱アシル化酵素は外膜のアミノアラビノース修飾を認識する

    眞鍋貴行, 川崎清史

    日本細菌学雑誌  2008 

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    Event date： 2008

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  • Lipid A修飾酵素PagLの活性抑制に関与するアミノ酸残基の同定

    眞鍋 貴行, 西島 正弘, 川崎 清史

    日本薬学会（第127回大会）  日本薬学会

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    Event date： 2007.3

    Language：Japanese   Presentation type：Poster presentation  

    Venue：富山  

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  • LPS脱アシル化酵素の活性調節に関与するアミノ酸残基の同定

    眞鍋貴行, 西島正弘, 川崎清史

    生化学  2007 

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  • 上皮成長因子様リピートをもつ新規膜貫タンパク質

    眞鍋 貴行, 池永 喜一, 伊藤 文昭, 川崎 勝己

    日本分子生物学会（第28回大会）  日本分子生物学会

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    Event date： 2005.12

    Language：Japanese   Presentation type：Poster presentation  

    Venue：博多  

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  • EGF様リピートをもつ新規膜貫通蛋白質の細胞内ドメイン

    眞鍋 貴行, 西嶋 亜矢子, 伊藤 文昭, 川崎 勝己

    日本分子生物学会（第27回大会）  日本分子生物学会

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    Event date： 2004.12

    Language：Japanese   Presentation type：Poster presentation  

    Venue：横浜  

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  • メンケス病治療薬であるヒスチジン銅院内特殊製剤の長期保管条件の検討

    上野裕太, 眞鍋貴行, 新田悠一朗, 岩山 訓典, 神山直也, 山本譲, 中馬真幸, 田崎 嘉一

    第６回 医療薬学フレッシャーズカンファレンス  2023.6 

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  • 院内製剤10％リドカインゲルの有効性と安全性に関する後ろ向き観察研究

    菅谷香緒里、神山直也、眞鍋貴行、山本譲、中馬真幸、田﨑嘉一

    第16回 日本緩和医療薬学会  2023.5 

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  • 生体腎移植患者におけるタクロリムス血中濃度と体組成に関する検討

    久保 靖憲, 山本 譲, 眞鍋 貴行, 中馬 真幸, 松野 直徒, 田﨑 嘉一

    第49回日本臓器保存生物医学会学術集会  2023.10 

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  • 逸脱ワーキング活動の実践から見えた当院の傾向と課題

    畑山幸恵、眞鍋貴行、堀 康子、近藤夕子、小川真澄、谷 香苗、佐藤 幸、横山真利子、結城和美、松本成史

    第23回 CRCと臨床試験のあり方を考える会議  2023.9 

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  • 小児血液悪性腫瘍患者における発熱性好中球減少症に対するアルベカシンの有効性

    寺川央一, 中馬真幸, 都築仁美, 寒藤雅俊, 吉田祐花, 上杉紘一, 眞鍋貴行, 神山直也, 岩山訓典, 山本譲, 田﨑嘉一

    第33回 日本医療薬学会年会  2023.11 

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  • 有害事象自発報告データベースを用いた抗がん剤関連眼障害における転機及び発症時期の解析

    第33回 日本医療薬学会年会  2023.11 

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  • 小児におけるアルベカシンの体内動態に発熱性好中球減少症が及ぼす影響について

    都築仁美, 中馬真幸, 寺川央一, 寒藤雅俊, 岩山訓典, 山本譲, 久保靖憲, 神山直也, 眞鍋貴行, 田崎嘉一

    第32回 日本医療薬学会年会  2022.10 

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  • 腎移植患者におけるタクロリムス血中濃度と体組成に関する検討

    久保靖憲, 山本譲, 眞鍋貴行, 中馬真幸, 松野直徒, 田﨑嘉一

    第58回 日本移植学会総会  2022.10 

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  • バイアル製剤の分割調製を目指した、模擬バイアルによる複数回穿刺での長期無菌性条件の検討

    新田 悠一朗, 眞鍋 貴行, 松浦 泰寛, 仲谷 彰規, 石川 良太, 岩山 訓典, 神山 直也, 山本 譲, 中馬 真幸, 小野 尚志, 田崎 嘉一

    "日本臨床腫瘍薬学会学術大会 JASPO 2023"  2023.3 

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  • アドレナリン含有リドカイン塩酸塩注射液とリドカイン塩酸塩注射液の等量混合希釈時におけるアドレナリンの安定性

    久保 靖憲, 山本 譲, 眞鍋 貴行, 岩山 訓典, 神山 直也, 山下 恭範, 小野 尚志, 中馬 真幸, 田﨑 嘉一

    第143回 日本薬学会  2023.3 

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  • ICF共通テンプレートを導入して感じた温度感 Invited

    眞鍋貴行

    第24回 CRCと臨床試験のあり方を考える会議  2024.9 

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    Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

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  • ヒスチジン銅院内特殊製剤の家庭内長期安定性に関する研究

    第33回 日本医療薬学会年会  2023.11 

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  • 炎症性腸疾患の薬物治療法の質向上を目指した薬剤師外来の効果

    岩山訓典, 上野伸展, 眞鍋貴行, 菅野諒太, 石川良太, 山本 譲, 安藤勝祥, 藤谷幹浩, 田﨑嘉一

    第14回 日本炎症性腸疾患学  2023.12 

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  • 被験者組入れ促進を目指した地域フリーペーパーへの被験者募集広告の工夫

    堀 康子, 眞鍋貴行, 小川真澄, 北川美雪, 青木菜月, 畑山幸恵, 近藤夕子, 神山直也, 田崎嘉一, 松本成史

    第24回 CRCと臨床試験のあり方を考える会議  2024.9 

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  • ヒドロモルフォン塩酸塩注導入直後の用量変更の発生状況

    菅谷香緒里, 神山直也, 眞鍋貴行, 山本香緒里, 山本譲, 小野尚志, 中馬真幸, 小野寺美子, 田崎嘉一

    第17回 日本緩和医療薬学会年会  2024.5 

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  • 治験品質の効率的な向上を目指した逸脱報告書の改訂と逸脱管理プロセスの構築

    小川真澄, 眞鍋貴行, 近藤夕子, 畑山幸恵, 谷香苗, 佐藤幸, 横山真利子, 結城和美, 神山直也, 松本成史

    第22回 CRCと臨床試験のあり方を考える会議  2022.9 

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  • mTOR complex2活性阻害はメロキシカムのMPP+誘発性神経細胞死保護作用を抑制させる

    松浦 泰寛, 眞鍋 貴行, 大久保 知子, 田崎 嘉一

    第145回 日本薬学会 年会  2025.3 

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  • 医薬品副作用データベースを用いた間質性肺疾患に対する免疫・アレルギー系薬剤及び鎮痛薬併用の予防薬効果の探索とinvitroにおける薬効評価

    貴志結香, 岩山訓典, 眞鍋貴行, 石野匠人, 今井なつみ, 相馬まゆ子, 町田麻依子, 今田愛也

    第145回 日本薬学会  2025.3 

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  • 医薬品副作用データベースを用いた間質性肺疾患に対する心血管系薬剤併用の予防薬効果の探索とinvitroにおける薬効評価

    今井なつみ, 岩山訓典, 眞鍋貴行, 石野匠人, 貴志結香, 相馬まゆ子, 町田麻依子, 今田愛也

    第145回 日本薬学会  2025.3 

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  • 医薬品副作用データベースを用いた間質性肺疾患に対する消化器系薬剤併用の予防薬効果の探索とinvitroにおける薬効評価

    石野匠人, 岩山訓典, 眞鍋貴行, 今井なつみ, 貴志結香, 相馬まゆ子, 町田麻依子, 今田愛也

    第145回 日本薬学会  2025.3 

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  • 敗血症患者におけるバンコマイシンの初期投与設計と早期AUCとの関係

    上杉 紘一, 中馬 真幸, 寺川 央一, 都築 仁美, 寒藤 雅俊, 井上正朝, 山本 譲, 岩山 訓典, 神山 直也, 眞鍋 貴行, 田崎 嘉一

    令和6年度 旭川薬剤師会・旭川病院薬剤師会合同フォーラム  2025.2 

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  • RAW264.7細胞を用いた炎症モデルにおけるテトラサイクリン系抗菌薬の影響

    水上紗良, 岩山訓典, 眞鍋貴行, 長屋奏絵, 秋山雄, 大櫛凛, 大杉愛奈, 相馬まゆ子, 佐藤恵亮, 町田麻依子, 今田愛也

    第145回 日本薬学会  2025.3 

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Research Projects

  • ビッグデータの融合解析を基盤にした尿細管保護薬の開発

    Grant number：23K06208  2023.4 - 2027.3

    日本学術振興会  科学研究費補助金  基盤C

    中馬 真幸, 田﨑 嘉一, 眞鍋 貴行

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  • 神経細胞保護効果を有する新規パーキンソン病治療薬の開発

    2023.4 - 2025.3

    日本医療開発機構 橋渡し研究プログラムpreF 

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    Authorship：Coinvestigator(s) 

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  • メロキシカムの新規パーキンソン病進行抑制薬としてのターゲット分子の同定

    2022.11 - 2023.8

    旭川医科大学 

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  • Elucidation of mechanism the anti-parkinsonian drug of meloxicam with progression inhibition in academia

    Grant number：18K14973  2018.4 - 2021.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Early-Career Scientists

    Manabe Takayuki

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