Updated on 2025/04/18

写真a

 
YUZAWA Sayaka
 
Organization
Hospital Central Clinical Facilities Surgical Pathology Department
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Degree

  • 博士 (医学) ( 2016.6   北海道大学 )

Education

  • Hokkaido University   Graduate School, Division of Medicine

    - 2016.6

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    Country： Japan

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  • Hokkaido University   Faculty of Medicine

    - 2012.3

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    Country： Japan

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Research History

  • Asahikawa Medical College   Lecturer

    2019.7

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  • Asahikawa Medical College   Assistant Professor

    2017.4 - 2019.6

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Professional Memberships

Papers

  • Meningitis due to inflammatory reaction to Echinococcus antigen after the resection of cerebral alveolar hydatid cyst. Reviewed International journal

    Taishin Yoshida, Shota Yamamoto, Sayaka Yuzawa, Takuma Takano, Takahiro Sanada, Masato Saito, Mishie Tanino, Manabu Kinoshita

    Journal of surgical case reports   2025 ( 2 )   rjaf072   2025.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    Meningitis after resection of a cerebral alveolar hydatid cyst (CAHC) is rare. Although several etiologies are proposed for meningitis, including recurrence or inflammatory reaction to dead echinococcal antigens, the effectiveness of treatment strategies specifically targeting the inflammatory reaction has not been reported. A 72-year-old patient presented with a brain cyst suggestive of CAHC. The cyst ruptured during resection, which was immediately replaced with 95% ethanol to obliterate the viable larvae, followed by cyst removal. One-month post-surgery, the patient showed signs of meningitis suggestive of a recurrence of cerebral hydatidosis. However, the negative sign of the recurrence on the brain and whole spine MRI suggested an inflammatory reaction to the obliterated Echinococcus antigen. An increased dose of prednisone resulted in the patient's complete recovery without recurrence for 1.8 years. Adding steroids to the anthelmintic maintenance treatment could be reasonable if the inflammatory reaction is more likely to be the cause.

    DOI： 10.1093/jscr/rjaf072

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  • Diagnosis of Isocitrate Dehydrogenase-Mutant Astrocytoma in the Subcallosal Gyrus Using T2-Fluid-Attenuated Inversion Recovery Mismatch Sign and Quantitative Magnetic Resonance Relaxometry. Reviewed International journal

    Yu Tajima, Sayaka Yuzawa, Yonehiro Kanemura, Mishie Tanino, Manabu Kinoshita

    Cureus   17 ( 1 )   e76963   2025.1

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    Astrocytoma, isocitrate dehydrogenase (IDH)-mutant, is one of the intraparenchymal brain tumors, strictly defined by its molecular characteristics. This tumor type is typically found in the frontal, insular, and temporal lobes. Patients harboring this type of tumor benefit the most from aggressive tumor removal compared to other low-grade appearing gliomas. Thus, accurate preoperative diagnosis is crucial in providing these patients with the most efficient and effective treatment strategy. This case study presents a 40-year-old male with an IDH-mutant astrocytoma in the subcallosal gyrus, an unusual location. The diagnosis was aided by the presence of the "T2-FLAIR (fluid-attenuated inversion recovery) mismatch sign," a key radiological feature of IDH-mutant astrocytomas, accompanied by magnetic resonance (MR) relaxometry that allows quantitative tissue characterization. This case highlights the importance of combining qualitative imaging features, such as the T2-FLAIR mismatch sign, with quantitative data, such as MR relaxometry, for accurate diagnosis, especially in cases with unusual tumor locations.

    DOI： 10.7759/cureus.76963

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  • Unresectable Ulcerative Colitis Associated Colon Cancer in a Young Japanese Patient: A Case Report. Reviewed

    Ryunosuke Hayashi, Nobuhiro Ueno, Hiromu Watanabe, Yu Kobayashi, Aki Sakatani, Keitaro Takahashi, Sayaka Yuzawa, Katsuyoshi Ando, Chikayoshi Tani, Shin Kashima, Tatsuya Shonaka, Kentaro Moriichi, Hiroki Tanabe, Mishie Tanino, Mikihiro Fujiya

    Internal medicine (Tokyo, Japan)   2024.10

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    We herein present the case of a 30-year-old Japanese male patient with ulcerative colitis (UC) who was admitted to our hospital because of significant ascites. Upon evaluation, the patient was diagnosed with unresectable UC-associated cancer (UCAC), localized in the transverse colon. Using gene profiling of the tumor tissue, anti-epidermal growth factor receptor (EGFR) antibody combination chemotherapy was selected. Subsequently, the patient exhibited a temporary response to this regimen, with an enhancement in his quality of life and he was able to survive for 12 months. This case underscores the potential benefits of aggressive chemotherapy tailored to the gene profile in UCAC treatment, offering insights into potential avenues for improving the patient prognosis.

    DOI： 10.2169/internalmedicine.4160-24

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  • A case of masquerade syndrome caused by metastatic iris tumor diagnosed by a high CEA level in the aqueous humor and iris biopsy. Reviewed International journal

    Shun Konno, Sayaka Yuzawa, Reiko Kinouchi

    Diagnostic pathology   19 ( 1 )   128 - 128   2024.9

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    BACKGROUND: With the advent of targeted therapies, the survival prognosis for metastatic tumors has extended, and it has become necessary to diagnose and consider treatment that takes into account Quality of Life for metastatic tumors of the eye. The reports of checking tumor marker in the aqueous humor for diagnosis of metastatic intraocular tumors are few. Here, we report a case of masquerade syndrome with secondary glaucoma in which a high carcinoembryonic antigen (CEA) level in the aqueous humor could assist diagnosis, and continuing targeted therapy and trabeculectomy were effective. CASE PRESENTATION: A 73-year-old man was referred to us for iritis and high intraocular pressure (IOP) with severe eye pain in the left eye. He had Stage IVB lung adenocarcinoma treated with a molecularly targeted drug, Osimertinib. His best corrected visual acuity was 0.15, and IOP was 52 mmHg in the left eye. Anterior chamber cells (+), numerous small nodules in the iris, and small masses in the inferior angle were observed. In the aqueous humor, the CEA level was higher than in the blood. Napsin A and Thyroid Transcription Factor-1 (TTF-1) positive cells showed in the resected tissue at iridectomy performed during trabeculectomy. The pathological diagnosis of metastatic iris tumor of the lung adenocarcinoma was made, and we injected bevacizumab intravitreally once and continued Osimertinib. His IOP lowered to 8-10 mmHg, and the iris masses disappeared. He lost vision by metastasis to the left optic nerve after termination of Osimertinib one and a half years later. The metastasis shrank after restarting the drug. He passed away from an exacerbation of his primary lung cancer two years and nine months after the first visit. Although he lost vision in his left eye, the metastatic tumor in his left eye and optic nerve had disappeared, and his quality of life was maintained without any pain in his eye. CONCLUSIONS: Checking tumor markers in the aqueous humor can aid in diagnosis, and aggressive treatment of metastatic iris tumors must help maintain patients' Quality of Life.

    DOI： 10.1186/s13000-024-01553-7

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  • Comparison of diagnostic accuracy between linked color imaging and autofluorescence imaging in patients with ulcerative colitis: A prospective observational study. Reviewed International journal

    Yuya Sugiyama, Keitaro Takahashi, Takahiro Sasaki, Nobuhiro Ueno, Hiromu Watanabe, Kohei Iribe, Shunya Sekiguchi, Shion Tachibana, Yu Kobayashi, Katsuyoshi Ando, Shin Kashima, Kentaro Moriichi, Hiroki Tanabe, Sayaka Yuzawa, Mikihiro Fujiya

    Journal of gastroenterology and hepatology   39 ( 8 )   1606 - 1612   2024.8

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    BACKGROUND AND AIM: Image enhancement endoscopy techniques, such as linked color imaging (LCI) and autofluorescence imaging (AFI), have shown promise in diagnosing mucosal inflammation in ulcerative colitis (UC). However, no studies have directly compared the diagnostic efficacy of LCI and AFI. This prospective observational study aimed to compare their diagnostic accuracy for histological healing in UC. METHODS: This study included 81 UC patients, resulting in a total of 204 endoscopic images captured using LCI and AFI, respectively. Spearman's rank correlation coefficients assessed the correlation between LCI and AFI coloration and Geboes histopathology score (GHS). Six endoscopists, who were blinded to clinicopathological features, evaluated these images, and subsequently, the diagnostic accuracy was evaluated. RESULTS: Spearman's rank correlation coefficients between LCI index, AFI index (reverse gamma value), and GHS were 0.324 and -0.428, respectively (P < 0.001), indicating a significant correlation between LCI and AFI coloration and histological healing. In LCI and AFI classifications, mean values for diagnostic accuracy, sensitivity, specificity, positive predictive value, and negative predictive value were 76.3 ± 2.2 versus 77.8 ± 2.7, 91.8 ± 4.0 versus 83.2 ± 7.6, 53.4 ± 10.0 versus 70.0 ± 5.3, 74.0 ± 3.5 versus 80.0 ± 1.6, and 82.9 ± 5.2 versus 75.5 ± 7.5, respectively. No significant difference in diagnostic accuracy existed between LCI and AFI classifications. However, LCI displayed higher sensitivity than AFI while AFI showed higher specificity compared with LCI (P < 0.05). CONCLUSIONS: LCI and AFI offer comparable diagnostic accuracy for histological healing. Clinically, it is necessary to recognize diagnostic features characterized by higher sensitivity in LCI and greater specificity in AFI.

    DOI： 10.1111/jgh.16586

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  • The white ring sign is useful for differentiating between fundic gland polyps and gastric adenocarcinoma of the fundic gland type. Reviewed International journal

    Keitaro Takahashi, Takahiro Sasaki, Nobuhiro Ueno, Haruka Maguchi, Shion Tachibana, Ryunosuke Hayashi, Yu Kobayashi, Yuya Sugiyama, Aki Sakatani, Katsuyoshi Ando, Shin Kashima, Kentaro Moriichi, Hiroki Tanabe, Kazumichi Harada, Sayaka Yuzawa, Shin Ichihara, Toshikatsu Okumura, Mikihiro Fujiya

    Endoscopy international open   12 ( 6 )   E723-E731   2024.6

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    Background and study aims Gastric adenocarcinoma of the fundic gland type (GA-FG) is characterized by an elevated lesion with vessel dilation exhibiting branching architecture (DVBA). However, this feature is also found in fundic gland polyps (FGPs), posing a challenge in their differentiation. In this study, we aimed to investigate the clinicopathological features of gastric elevated lesions with DVBA and assess the efficacy of the white ring sign (WRS) as a novel marker for distinguishing between FGPs and GA-FGs. Methods We analyzed 159 gastric elevated lesions without DVBA and 51 gastric elevated lesions with DVBA, further dividing the latter into 39 in the WRS-positive group and 12 in the WRS-negative group. The clinicopathological features, diagnostic accuracy, and inter-rater reliability were analyzed. Results Univariate and multivariate analyses for gastric elevated lesions with DVBA identified the histological type consistent with FGPs and GA-FGs, along with the presence of round pits in the background gastric mucosa, as independent predictors. FGPs were present in 92.3% (36/39) of the WRS-positive group and GA-FGs were observed in 50.0% (6/12) of the WRS-negative group. WRS positivity and negativity exhibited high diagnostic accuracy, with 100% sensitivity, 80.0% specificity, and 94.1% accuracy for FGPs, and 100% sensitivity, 86.7% specificity, and 88.2% accuracy for GA-FGs. Kappa values for WRS between experts and nonexperts were 0.891 and 0.841, respectively, indicating excellent agreement. Conclusions WRS positivity and negativity demonstrate high diagnostic accuracy and inter-rater reliability for FGPs and GA-FGs, respectively, suggesting that WRS is a useful novel marker for distinguishing between FGPs and GA-FGs.

    DOI： 10.1055/a-2301-6248

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  • Evaluating Cellularity Estimation Methods: Comparing AI Counting with Pathologists' Visual Estimates. Reviewed International journal

    Tomoharu Kiyuna, Eric Cosatto, Kanako C Hatanaka, Tomoyuki Yokose, Koji Tsuta, Noriko Motoi, Keishi Makita, Ai Shimizu, Toshiya Shinohara, Akira Suzuki, Emi Takakuwa, Yasunari Takakuwa, Takahiro Tsuji, Mitsuhiro Tsujiwaki, Mitsuru Yanai, Sayaka Yuzawa, Maki Ogura, Yutaka Hatanaka

    Diagnostics (Basel, Switzerland)   14 ( 11 )   2024.5

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    The development of next-generation sequencing (NGS) has enabled the discovery of cancer-specific driver gene alternations, making precision medicine possible. However, accurate genetic testing requires a sufficient amount of tumor cells in the specimen. The evaluation of tumor content ratio (TCR) from hematoxylin and eosin (H&E)-stained images has been found to vary between pathologists, making it an important challenge to obtain an accurate TCR. In this study, three pathologists exhaustively labeled all cells in 41 regions from 41 lung cancer cases as either tumor, non-tumor or indistinguishable, thus establishing a "gold standard" TCR. We then compared the accuracy of the TCR estimated by 13 pathologists based on visual assessment and the TCR calculated by an AI model that we have developed. It is a compact and fast model that follows a fully convolutional neural network architecture and produces cell detection maps which can be efficiently post-processed to obtain tumor and non-tumor cell counts from which TCR is calculated. Its raw cell detection accuracy is 92% while its classification accuracy is 84%. The results show that the error between the gold standard TCR and the AI calculation was significantly smaller than that between the gold standard TCR and the pathologist's visual assessment (p<0.05). Additionally, the robustness of AI models across institutions is a key issue and we demonstrate that the variation in AI was smaller than that in the average of pathologists when evaluated by institution. These findings suggest that the accuracy of tumor cellularity assessments in clinical workflows is significantly improved by the introduction of robust AI models, leading to more efficient genetic testing and ultimately to better patient outcomes.

    DOI： 10.3390/diagnostics14111115

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  • Granulocyte colony-stimulating factor-producing lung cancer complicated with antiphospholipid antibody syndrome: a case report. Reviewed International journal

    Ryusei Yoshino, Masaki Nakatsubo, Nanami Ujiie, Sayaka Yuzawa, Kensuke Ishida, Masahiro Kitada

    Journal of surgical case reports   2024 ( 5 )   rjae361   2024.5

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    No reports on granulocyte colony-stimulating factor-producing lung cancer associated with antiphospholipid antibody syndrome. A 73-year-old man was referred to our department to undergo surgery for lung cancer in the right upper lobe. His examination results suggested that his condition was caused by an elevated white blood cell count and an increased inflammatory response due to granulocyte colony-stimulating factor production. The presence of antiphospholipid antibody syndrome was suspected, and the decrease in coagulation factors was considered to be inhibited by the lupus anticoagulant. Perioperatively, the patient was treated with heparin and steroids, and a thoracoscopically assisted right upper lobectomy was performed. Postoperatively, histopathological examination revealed pleomorphic carcinoma, and the patient tested negative for anticardiolipin IgG antibodies. In lung cancer patients with elevated white blood cell counts, fever, and an inflammatory response, granulocyte colony-stimulating factor-producing lung cancer is an important differential diagnosis. Additionally, when coagulation abnormalities are observed preoperatively, a thorough examination is necessary to prepare for perioperative management.

    DOI： 10.1093/jscr/rjae361

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  • A case of non-bacterial thrombotic endocarditis on the aortic valve following coronary angiography. Reviewed International journal

    Nobuhiro Motiduki, Ryohei Ushioda, Sayaka Yuzawa, Kazuki Miyatani, Hideki Isa, Yuki Setogawa, Kohei Ishidou, Masahiko Narita, Fumitaka Suzuki, Aina Hirofuji, Ryo Okubo, Shingo Kunioka, Masahiro Tsutsui, Natsuya Ishikawa, Kamiya Hiroyuki

    Journal of surgical case reports   2024 ( 4 )   rjae212   2024.4

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    Nonbacterial thrombotic endocarditis (NBTE) on the aortic valve involves fibrin and platelet aggregate formation, potentially leading to embolic events. We present a case of NBTE on the aortic valve following coronary angiography (CAG) in a 54-year-old man with multiple comorbidities. Surgical thrombectomy was performed owing to acute cerebral infarcts. This case highlights the significance of considering that mechanical trauma from catheterization during CAG can trigger thrombus formation.

    DOI： 10.1093/jscr/rjae212

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  • Cardiac sarcoidosis in a patient with ulcerative colitis: A case report and literature review Reviewed

    Kentaro Moriichi, Shin Kashima, Yu Kobayashi, Yuya Sugiyama, Yuki Murakami, Takahiro Sasaki, Takehito Kunogi, Keitaro Takahashi, Katsuyoshi Ando, Nobuhiro Ueno, Hiroki Tanabe, Ayumi Date, Sayaka Yuzawa, Mikihiro Fujiya

    Medicine (Baltimore)   103 ( 1 )   e36207   2024.1

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    DOI： 10.1097/MD.0000000000036207

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  • 松果体腫瘍 Invited

    湯澤明夏, 谷野美智枝

    日本臨牀   81 ( 9 )   90 - 95   2023.12

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    Authorship：Lead author   Language：Japanese   Publishing type：Research paper (scientific journal)  

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  • Successful Multidisciplinary Treatment with Laparoscopic Hepatectomy and Adjuvant Therapy for Metachronous Solitary Hepatic Metastasis after Excision of a Primary Anorectal Malignant Melanoma: A Case Report Reviewed

    Ryotaro Shimazaki, Masahiro Hagiwara, Chikayoshi Tani, Hiroyoshi Iwata, Hiroyuki Takahashi, Marika Fukuyama, Taisuke Matsuya, Koji Imai, Sayaka Yuzawa, Mishie Tanino, Hideki Yokoo

    Current Oncology   31 ( 1 )   203 - 210   2023.12

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    DOI： 10.3390/curroncol31010013

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  • Primary Chondrosarcoma of the Right Fourth Rib Resected at the Marginal Margin: A Case Report Reviewed

    Ryusei Yoshino, Masaki Nakatsubo, Nanami Ujiie, Nana Yoshida, Sayaka Yuzawa, Masahiro Kitada

    Cureus   15 ( 12 )   e51251   2023.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.7759/cureus.51251

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  • Interventional Bridging Therapy for Radical Cardiac Surgery in a Patient Reviewed

    JeongA Lee, Masahiro Tsutsui, Nobuhiro Mochizuki, Yuki Setogawa, Fumitaka Suzuki, Masahiko Narita, Aina Hirofuji, Shingo Kunioka, Tomonori Shirasaka, Natsuya Ishikawa, Sayaka Yuzawa, Hiroyuki Kamiya

    The Heart Surgery Forum   26 ( 6 )   E676 - E679   2023.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.59958/hsf.5779

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  • Synchronous multiple lung cancers with hilar lymph node metastasis of small cell carcinoma: A case report Reviewed

    Ryusei Yoshino, Nana Yoshida, Shunsuke Yasuda, Akane Ito, Masaki Nakatsubo, Sayaka Yuzawa, Masahiro Kitada

    World Journal of Clinical Cases   11 ( 25 )   5919 - 5925   2023.9

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    DOI： 10.12998/wjcc.v11.i25.5919

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  • Solitary fibrous tumor resembling pulmonary fractionation disease: A case report Reviewed

    Ryusei Yoshino, Nana Yoshida, Akane Ito, Masaki Nakatsubo, Sayaka Yuzawa, Masahiro Kitada

    Medicine (Baltimore)   102 ( 27 )   e34290   2023.7

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    DOI： 10.1097/MD.0000000000034290

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  • 前額部隆起性皮膚線維肉腫の治療経験 Reviewed

    宮田 夏実, 西尾 卓哉, 市原 寛大, 宮田 明久生, 山尾 健, 湯澤 明夏, 林 利彦

    日本形成外科学会会誌   43 ( 7 )   395 - 402   2023.7

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.57414/jjpnprs.43.7_395

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  • Early recurrence of Rosai-Doefman disease after total removal resection: a case report Reviewed

    Hirotaka Sato, Masato Saito, Sayaka Yuzawa, Ryogo Anei

    British Journal of Neurosurgery   37 ( 3 )   413 - 415   2023.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1080/02688697.2020.1817316

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  • A case of lymphoma mimicking infected internal iliac artery aneurysm Reviewed

    Yohei Ichikawa, Shinsuke Kikuchi, Hiroya Moriyama, Takamitsu Tatsukawa, Seima Ohira, Yuki Kamikokura, Yuri Yoshida, Mayumi Hatayama, Sayaka Yuzawa, Naoki Wada, Daiki Uchida, Atsuhiro Koya, Nobuyoshi Azuma

    Surgical Case Reports   9 ( 1 )   84   2023.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1186/s40792-023-01665-0

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  • The Effectiveness of the Combination of Arterial Infusion Chemotherapy and Radiotherapy for Biliary Tract Cancer: A Prospective Pilot Study Reviewed

    Takuma Goto, Hiroki Sato, Shugo Fujibayashi, Tetsuhiro Okada, Akihiro Hayashi, Hidemasa Kawabata, Sayaka Yuzawa, Syunta Ishitoya, Masaaki Yamashina, Mikihiro Fujiya

    Cancers (Basel)   15 ( 9 )   2616   2023.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3390/cancers15092616

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  • Concurrent Granulomatous Mastitis and Ductal Carcinoma In Situ Reviewed

    Nana Yoshida, Masaki Nakatsubo, Ryusei Yoshino, Akane Ito, Nanami Ujiie, Sayaka Yuzawa, Masahiro Kitada

    Cureus   15 ( 5 )   e38377   2023.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.7759/cureus.38377

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  • Low-grade papillary Schneiderian carcinoma with TP53 mutation: a case report and review of the literature Reviewed

    Sayaka Yuzawa, Tomohiko Michizuka, Rika Kakisaka, Yusuke Ono, Manami Hayashi, Miki Takahara, Akihiro Katada, Yusuke Mizukami, Mishie Tanino

    Diagnostic Pathology   18 ( 1 )   44   2023.4

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1186/s13000-023-01334-8

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  • 多発性内分泌腫瘍症1型に合併した胸腺神経内分泌腫瘍 Reviewed

    伊藤 茜, 中坪 正樹, 吉野 流世, 安田 俊輔, 吉田 奈七, 北田 正博, 湯澤 明夏

    胸部外科   76 ( 4 )   324 - 327   2023.4

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.15106/j_kyobu76_324

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  • Rituximabが著効したステロイドとtocilizumab抵抗性TAFRO症候群 Reviewed

    鷲見 千紘, 土岐 康通, 船山 拓也, 齋藤 豪志, 畑山 真弓, 山本 昌代, 進藤 基博, 湯澤 明夏, 谷野 美智枝, 奥村 利勝

    臨床血液   64 ( 4 )   265 - 270   2023.4

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.11406/rinketsu.64.265

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  • 中枢神経系血液系腫瘍 Invited Reviewed

    湯澤明夏, 谷野美智枝

    病理と臨床   41 ( 2 )   128 - 134   2023.1

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  • Local recurrence after successful endoscopic submucosal dissection for rectal mucinous mucosal adenocarcinoma: A case report Reviewed

    Yuki Murakami, Hiroki Tanabe, Yusuke Ono, Yuya Sugiyama, Yu Kobayashi, Takehito Kunogi, Takahiro Sasaki, Keitaro Takahashi, Katsuyoshi Ando, Nobuhiro Ueno, Shin Kashima, Sayaka Yuzawa, Kentaro Moriichi, Yusuke Mizukami, Mikihiro Fujiya, Toshikatsu Okumura

    World Journal of Gastrointestinal Oncology   15 ( 1 )   186 - 194   2023.1

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    DOI： 10.4251/wjgo.v15.i1.186

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  • 髄膜腫 Invited Reviewed

    小田義崇, 湯澤明夏, 田中伸哉

    病理と臨床   41 ( 1 )   64 - 71   2022.12

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  • Subcellular localization of hTERT in breast cancer: insights into its tumorigenesis and drug resistance mechanisms in HER2-immunopositive breast cancer Reviewed

    Yuji Uno, Hiroki Tanaka, Keita Miyakawa, Naoko Akiyama, Yuki Kamikokura, Sayaka Yuzawa, Masahiro Kitada, Hidehiro Takei, Mishie Tanino

    Human Pathology   134   74 - 84   2022.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.humpath.2022.12.010

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  • Lymphoepithelioma-like cholangiocarcinoma not associated with Epstein-Barr virus or hepatitis virus: case report and literature review of 100 reported cases Reviewed

    Yuki Adachi, Hideki Yokoo, Masahiro Hagiwara, Hiroyuki Takahashi, Hiroyoshi Iwata, Tomohiro Takeda, Tomohiro Yamamoto, Koji Imai, Sayaka Yuzawa, Mishie Tanino, Naoto Matsuno

    Therapeutic Advances in Medical Oncology   14   17588359221133169   2022.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1177/17588359221133169

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  • 糖尿病と齲歯のある高齢者に発症したノカルジア脳膿瘍 Reviewed

    福山 秀青, 湯澤 明夏, 真田 隆広, 齋藤 仁十, 広島 覚, 安栄 良悟, 木下 学

    脳神経外科速報   32 ( 5 )   e10 - e18   2022.9

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  • Analysis of induced pluripotent stem cell clones derived from a patient with mosaic neurofibromatosis type 2 Reviewed

    Yukitomo Ishi, Takumi Era, Sayaka Yuzawa, Michinari Okamoto, Ryosuke Sawaya, Hiroaki Motegi, Shigeru Yamaguchi, Shunsuke Terasaka, Kiyohiro Houkin, Miki Fujimura

    American Journal of Medical Genetics Part A   2022.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/ajmg.a.62700

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  • Prognostic factors to predict the survival in patients with advanced gastric cancer who receive later-line nivolumab monotherapy-The Asahikawa Gastric Cancer Cohort Study (AGCC) Reviewed

    Kazuyuki Tanaka, Hiroki Tanabe, Hiroki Sato, Chisato Ishikawa, Mitsuru Goto, Naoyuki Yanagida, Hiromitsu Akabane, Shiro Yokohama, Kimiharu Hasegawa, Yohei Kitano, Yuya Sugiyama, Kyoko Uehara, Yu Kobayashi, Yuki Murakami, Takehito Kunogi, Takahiro Sasaki, Keitaro Takahashi, Katsuyoshi Ando, Nobuhiro Ueno, Shin Kashima, Kentaro Moriichi, Keisuke Sato, Sayaka Yuzawa, Mishie Tanino, Masaki Taruiishi, Yasuo Sumi, Yusuke Mizukami, Mikihiro Fujiya, Toshikatsu Okumura

    Cancer Medicine   11 ( 2 )   406 - 416   2022.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/cam4.4461

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  • Development of pulmonary sarcoidosis in Crohn's disease patient under infliximab biosimilar treatment after long-term original infliximab treatment: a case report and literature review Reviewed

    Shin Kashima, Kentaro Moriichi, Katsuyoshi Ando, Nobuhiro Ueno, Hiroki Tanabe, Sayaka Yuzawa, Mikihiro Fujiya

    BMC Gastroenterology   21 ( 1 )   373   2021.10

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    DOI： 10.1186/s12876-021-01948-6

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  • Superficial myofibroblastoma of the vagina with a stalk: case report of a rare vaginal tumor with notable radiological findings Reviewed

    Yui Tomita, Eriko Takabayashi, Sayaka Yuzawa, Atsutaka Okizaki

    Radiology Case Reports   16 ( 12 )   3690 - 3694   2021.10

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    DOI： 10.1016/j.radcr.2021.08.064

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  • Clinicopathological characteristics of Epstein-Barr virus and microsatellite instability subtypes of early gastric neoplasms classified by the Japanese and the World Health Organization criteria Reviewed

    Hiroki Tanabe, Yusuke Mizukami, Hidehiro Takei, Nobue Tamamura, Yuhi Omura, Yu Kobayashi, Yuki Murakami, Takehito Kunogi, Takahiro Sasaki, Keitaro Takahashi, Katsuyoshi Ando, Nobuhiro Ueno, Shin Kashima, Sayaka Yuzawa, Kimiharu Hasegawa, Yasuo Sumi, Mishie Tanino, Mikihiro Fujiya, Toshikatsu Okumura

    Jlurnal of Pathology: Clnical Research   7 ( 4 )   397 - 409   2021.7

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    DOI： 10.1002/cjp2.209

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  • Malignant transformation of NF1-associated spinal astrocytoma with loss of ATRX expression during the course: A case report Reviewed

    Sayaka Yuzawa, Yuki Kamikokura, Mishie Tanino, Hidehiro Takei

    Clinical Neuropathology   40 ( 4 )   201 - 208   2021.7

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.5414/NP301314

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  • Long-term observation of gastric adenocarcinoma of fundic gland mucosa type before and after Helicobacter pylori eradication: A case report Reviewed

    Keitaro Takahashi, Nobuhiro Ueno, Takahiro Sasaki, Yu Kobayashi, Yuya Sugiyama, Yuki Murakami, Takehito Kunogi, Katsuyoshi Ando, Shin Kashima, Kentaro Moriichi, Hiroki Tanabe, Yuki Kamikokura, Sayaka Yuzawa, Mishie Tanino, Toshikatsu Okumura, Mikihiro Fujiya

    Journal of Gastric Cancer   21 ( 1 )   103 - 109   2021.5

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    DOI： 10.5230/jgc.2021.21.e11

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  • A case of insulinoma diagnosed postpartum with hypoglycemic symptoms that were masked during pregnancy Reviewed

    Tomoe Abe, Yasutaka Takeda, Takao Takiyama, Ayaka Sasaki, Ryoichi Bessho, Mao Sato, Hiroya Kitsunai, Hidemitsu Sakagami, Atsuko Abiko, Koji Imai, Sayaka Yuzawa, Mishie Tanino, Yumi Takiyama

    Clinical Case Reports   9 ( 4 )   1991 - 1998   2021.2

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  • Dasatinib-induced panniculitis in a patient with chronic myeloid leukaemia. Reviewed

    Yusuke Nagasawa, Shin Iinuma, Mizue Fujii, Kyoko Kanno, Masaru Honma, Sayaka Yuzawa, Akemi Ishida-Yamamoto

    European Journal of Dermatology   31 ( 1 )   87 - 88   2021.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1684/ejd.2020.3946

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  • Endoscopic findings of gastric mixed adenoneuroendocrine carcinoma: A case report Reviewed

    Keitaro Takahashi, Mikihiro Fujiya, Takahiro Sasaki, Yuya Sugiyama, Yuki Murakami, Takuya Iwama, Takehito Kunogi, Katsuyoshi Ando, Nobuhiro Ueno, Shin Kashima, Kentaro Moriichi, Hiroki Tanabe, Sayaka Yuzawa, Hidehiro Takei, Toshikatsu Okumura

    Medicine (Baltimore)   99 ( 38 )   e22306   2020.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1097/MD.0000000000022306.

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  • The value and practical utility of intraoperative touch imprint cytology of sentinel lymph node(s) in patients with breast cancer: A retrospective cytology-histology correlation study. Reviewed

    Yuji Uno, Naoko Akiyama, Sayaka Yuzawa, Masahiro Kitada, Hidehiro Takei

    Cytojournal   2020.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.25259/Cytojournal_80_2019

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  • Pleural sarcomatoid mesothelioma with an interstitial growth pattern Reviewed

    Miyakawa K., Yamamoto M., Akiyama N., Sado M., Okizaki A., Nishikawa Y., Takei H., Tanino M.

    Pathology International   70 ( 2 )   126 - 128   2020

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  • Long-term growth of intrahepatic papillary neoplasms: A case report

    Takumu Hasebe, Koji Sawada, Hidemi Hayashi, Shunsuke Nakajima, Hiroyuki Takahashi, Masahiro Hagiwara, Koji Imai, Sayaka Yuzawa, Mikihiro Fujiya, Hiroyuki Furukawa, Toshikatsu Okumura

    WORLD JOURNAL OF GASTROENTEROLOGY   25 ( 36 )   5569 - 5577   2019.9

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：BAISHIDENG PUBLISHING GROUP INC  

    BACKGROUNDIntraductal papillary neoplasm of the bile duct (IPNB) is a type of tumor that presents in the intra- or extrahepatic bile ducts. Cystic-type intrahepatic IPNB often mimics simple liver cysts, making the diagnosis difficult. Because the growth of IPNB is slow, careful follow-up and timely therapeutic intervention is recommended. There are few reports with a follow-up period longer than a decade; thus, we report the case of a patient with an IPNB that grew for over 13 years.CASE SUMMARYA 65-year-old man was diagnosed, 13 years prior with a cystic hepatic tumor with abnormal imaging findings. The targeted tumor biopsy results showed no malignancy. Biannual follow-up examinations were performed because of the potential for malignancy. The cystic lesions showed gradual enlargement over 11 years and a 4 mm papillary proliferation appeared on the cyst wall, which is compatible with IPNB. The tumor was observed for another 2 years because of the patient's wishes. The imaging findings showed enlargement to 8 mm and a new 9 mm papillary proliferation of the cystic tumor. Contrast-enhanced ultrasonography showed hyperenhancement during the arterial phase in both cyst wails, indicating intraductal tumor progression in both tumors. Thus, liver segment 8 subsegmentectomy was performed. The pathological findings indicated that the tumors contained mucin, and high-grade atypia was observed in the papillary lesions, showing IPNB.CONCLUSIONThe development of IPNB should be monitored in patients with cystic lesions and ultrasonography are useful tool for the evaluation.

    DOI： 10.3748/wjg.v25.i36.5569

    Web of Science

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    PubMed

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  • Long-term growth of intrahepatic papillary neoplasms: A case report Reviewed

    Hasebe T., Sawada K., Hayashi H., Nakajima S., Takahashi H., Hagiwara M., Imai K., Fujiya M., Furukawa H., Okumura T.

    World Journal of Gastroenterology   28 ( 25 )   5569 - 5577   2019

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  • Unusual manifestations of giant cell arteritis and granulomatosis with polyangiitis Reviewed

    Yoshimoto R., Tanaka K., Kawahata T., Takatori S., Takatori K., Eguchi K., Fujishiro D., Kodama S., Kobayashi A., Okamoto K., Ota T., Makino Y.

    Immunological Medicine   42 ( 2 )   94 - 98   2019

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  • Roles of the apparent diffusion coefficient and tumor volume in predicting tumor grade in patients with choroid plexus tumors.

    Sasaki T., Kim J., Moritani T., Capizzano AA, Sato SP, Sato Y., Kirby P., Ishitoya S., Oya A., Toda M., Yuzawa S., Takahashi K.

    Neuroradiology   60 ( 5 )   479 - 486   2018

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s00234-018-2008-2

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  • Disseminated toxoplasmosis after hematopoietic stem cell transplantation showing unusual magnetic resonance images Reviewed

    Tateno T., Onozawa M., Hashiguchi J., Ishio T., Matsuoka S., Kosugi-Kanaya M., Okada K., Shiratori S., Goto H., Kimura T., Sugita J., Nakagawa M., Hashimoto D., Kahata K., Fujimoto K., Endo T., Kondo T., Tanaka S., Hashino S., Teshima T.

    Transplant Infectious Disease   19 ( 4 )   2017

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  • SFT／HPCの術中迅速免疫細胞化学染色（R－ICC）を用いたSTAT6の有用性についての検討

    鈴鹿 淳, 森谷 純, 竹浪 智子, 漆戸 万紗那, 湯澤 明夏, 木村 太一, 西原 広史, 谷野 美智枝, 田中 伸哉

    北海道臨床細胞学会会報   25   15 - 18   2016

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  • EXO1 homozygous deletion suppresses the hydroxyurea sensitivity in anaplastic meningioma with extracranial metastases Reviewed

    Yoshimura S., Ohta T., Makita K., Yamamuro S., Ochai Y., Sumi K., Shijo K., Yoshino A., Homma T., Sugitani M., Nishihara H., Tanaka S.

    International Journal of Clinical and Experimental Medicine   9 ( 9 )   18618 - 18625   2016

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  • A case of giant cell-rich solitary fibrous tumor in the external auditory canal Reviewed

    Tanikawa S., Kunibe I., Nishihara H., Nagashima K., Tanaka S.

    Pathology International   66 ( 12 )   701 - 705   2016

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  • Giant annular purpuric eruption as a unique clinical manifestation of skin metastasis in apocrine carcinoma Reviewed

    Yamaguchi Y., Kitamura S., Hata H., Imafuku K., Tanaka S., Shimizu H.

    The Journal of the European Academy of Dermatology and Venereology   30 ( 6 )   1029 - 1031   2016

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  • Clinical impact of targeted amplicon sequencing for meningioma as a practical clinical-sequencing system.

    Yuzawa S., Nishihara H., Yamaguchi S., Mohri H., Wang L., Kimura T., Tsuda M., Tanino M., Kobayashi H., Terasaka S., Houkin K., Sato N., Tanaka S.

    Mod Pathol   29 ( 7 )   708 - 716   2016

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  • Analysis of NAB2-STAT6 gene fusion in 17 cases of meningeal solitary fibrous tumor/ hemangiopericytoma – review of the literature.

    Yuzawa S., Nishihara H., Wang L., Tsuda M., Kimura T., Tanino M., Tanaka S.

    Am J Surg Pathol   40 ( 8 )   1031 - 1040   2016

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  • (18)F-fluoromisonidazole positron emission tomography can predict pathological necrosis of brain tumors.

    Toyonaga T., Hirata K., Yamaguchi S., Hatanaka KC, Yuzawa S., Manabe O., Kobayashi K., Watanabe S., Shiga T., Terasaka S., Kobayashi H., Kuge Y., Tamaki N.

    Eur J Nucl Med Mol Imaging   43 ( 8 )   1469 - 1476   2016

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▼display all

Books

  • Color Atlas of Brain Tumor Pathology, 5th Edition

    （ Role： ContributorMeningioma② Chordoid meningioma, Clear cell meningioma, Atypical meingioma）

    2024.5  （ ISBN:9784260053297 ）

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    Total pages：xiii, 232p   Language：Japanese  

    CiNii Books

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  • 腫瘍病理鑑別診断アトラス 脳腫瘍 第2版

    横尾, 英明, 小森, 隆司, 腫瘍病理鑑別診断アトラス刊行委員会, 日本病理学会（ Role： Contributor松果体腫瘍）

    文光堂  2024.2  （ ISBN:9784830622700 ）

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  • 腫瘍病理鑑別診断アトラス 脳腫瘍

    小森隆司, 廣瀬隆則, 湯澤明夏（ Role： Joint author著書、「IDH野生型・膠芽腫」の項を執筆）

    文光堂  2017 

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    Language：Japanese   Book type：Scholarly book

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MISC

Presentations

  • BRAF V600E変異、ATRX欠失、CDKN2A/Bホモ接合性欠失を有し予後不良であった高悪性度星細胞腫の一例

    湯澤 明夏, 林 真奈実, 上小倉 佑機, 青木 直子, 山野 三紀, 安栄 良悟, 横尾 英明, 谷野 美智枝

    第69回日本病理学会秋期特別総会  日本病理学会

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    Event date： 2023.11

    Language：Japanese   Presentation type：Poster presentation  

    Venue：久留米  

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  • A case of EBV-positive diffuse large B-cell lymphoma arising from chronic aortic dissection

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    Event date： 2023.4

    Language：Japanese   Presentation type：Poster presentation  

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  • Low-grade papillary Schneiderian carcinomaの一例

    湯澤 明夏, 林 真奈実, 上小倉 佑機, 永田 真莉乃, 青木 直子, 道塚 智彦, 谷野 美智枝

    第111回日本病理学会総会 

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    Event date： 2022.4

    Language：English   Presentation type：Poster presentation  

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  • 多発子宮筋腫に対する子宮全摘を契機に発見された遺伝性平滑筋腫症腎細胞癌症候群 （HLRCC） の一例

    湯澤 明夏, 横浜 祐子, 蒔田 芳男, 古屋 充子, 谷野 美智枝, 武井 英博

    第66回日本病理学会秋期特別総会 

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    Event date： 2020.11

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Awards

  • The 2017 Young Investigator Award

    2017.11   Clinical impact of targeted amplicon sequencing for meningioma as a practical clinical-sequencing system

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  • 日本病理学会100周年記念病理学研究新人賞

    2016.4   日本病理学会   髄膜腫および髄膜発生孤立性線維性腫瘍/血管周皮腫の遺伝子解析

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Research Projects

  • 肺がん背景肺に潜むゲノム・エピゲノム異常の徹底的マッピングによる発がん機序の解明

    Grant number：22K06935  2022.4 - 2025.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    谷野 美智枝, 湯澤 明夏, 小山 恭平, 水上 裕輔

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    Grant amount：\4,160,000 （ Direct Cost: \3,200,000 、 Indirect Cost：\960,000 ）

    特発性肺線維症(Idiopathic Pulmonary Fibrosis, IPF)の患者では肺癌の発生率が高く、IPFを伴わない肺癌と比べて予後が有意に不良である。IPF合併肺癌のなかで最多の組織型である扁平上皮癌症例を対象とし、組織標本を用いて形態学的評価（過形成、異形成、上皮内癌、浸潤癌）及び免疫組織化学染色を行った。
    IPFを伴う肺扁平上皮癌5症例および、IPFを伴わず肺気腫やIPF以外の間質性肺炎を伴う肺扁平上皮癌18症例を解析対象として選定した。また、肺癌の診断または予後のマーカーとして有用性が報告されているメチル化解析のターゲット遺伝子を文献から検索し、そのなかから免疫組織化学染色の抗体が確立しているCDH13、CDKN2A、RASSF1を選定した。それらの免疫組織化学染色条件を検討し、対象症例において腫瘍部・非腫瘍部を含む代表的な箇所で免疫組織化学染色を実施した。多くはCDH13が発現し、CDKN2A・RASSF1の発現は消失していたが、一部の症例では異なる発現パターンを示した。
    エピゲノム解析手法の検証として、ヒト肺原発扁平上皮癌の細胞株であるEBC-1を培養してDNAを抽出し、メチル化の定量解析実験を行った。バイサルファイト処理したDNAからリアルタイムPCRによる定量解析の系を立ち上げている。臨床検体は、免疫組織化学染色を実施した腫瘍部および腫瘍周囲の非腫瘍部や、腫瘍から離れた背景肺からDNAを抽出した。確立した測定系を用いて、臨床サンプルにおけるメチル化の定量解析を実施し、免疫組織化学染色結果との検討、臨床因子との比較検討を行っている。

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Academic Activities

  • 北海道臨床細胞学会会報 査読

    Role(s)： Peer review

    北海道臨床細胞学会  2024.8 - 2024.9

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    Type：Peer review 

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