Faculty Profiles - NOHARA Fumikatsu

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NOHARA Fumikatsu

Organization

Hospital Central Clinical Facilities Center for Maternity and Infant Care

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Research History

Asahikawa Medical College Assistant Professor

2018.1

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Papers

【数値からみる周産期医療新生児編】血液凝固関係凝固能・DICスコアなど

野原史勝

周産期医学 53 ( 9 ) 1282 - 1288 2023.9

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Language：Japanese Publisher：(株)東京医学社

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2023&ichushi_jid=J00621&link_issn=&doc_id=20231003060006&doc_link_id=%2Faq9syuse%2F2023%2F005309%2F006%2F1282-1288%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Faq9syuse%2F2023%2F005309%2F006%2F1282-1288%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif
MCAD deficiency caused by compound heterozygous pathogenic variants in ACADM. International journal

Fumikatsu Nohara, Go Tajima, Hideo Sasai, Yoshio Makita

Human genome variation 9 ( 1 ) 2 - 2 2022.1

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Language：English Publishing type：Research paper (scientific journal)

Medium-chain acyl-coenzyme A dehydrogenase (MCAD) deficiency is an autosomal recessive disease caused by biallelic pathogenic ACADM variants. We report a case of an asymptomatic Japanese girl with MCAD deficiency caused by compound heterozygous pathogenic variants (NM_000016.5:c.1040G > T (p.Gly347Val) and c.449_452delCTGA (p.Thr150ArgfsTer4)). Because the MCAD residual activity in lymphocytes of the patient was below the limit of quantification, both variants are likely to cause complete loss of MCAD enzymatic activity.

DOI： 10.1038/s41439-021-00177-3

PubMed

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【サクッとチェック NICUからの退院&在宅医療支援サポート制度のポイントガイド】早産児のケース

野原史勝

with NEO 33 ( 6 ) 890 - 892 2020.12

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Language：Japanese Publisher：(株)メディカ出版

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2020&ichushi_jid=J07193&link_issn=&doc_id=20201110130009&doc_link_id=%2Fao7withi%2F2020%2F003306%2F014%2F0890-0892%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fao7withi%2F2020%2F003306%2F014%2F0890-0892%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif
北海道道北地域における新生児・乳児のビタミンD欠乏状況とビタミンD投与についての検討

野原史勝, 津田淳希, 芳賀俊介, 高橋はるか, 浅井霞, 山木ゆかり, 高橋健太, 高橋弘典, 土田悦司, 真鍋博美, 竹田津原野, 佐藤敬, 白井勝, 沖潤一, 杉山達俊, 青山藍子, 二井光麿, 岡本年男, 長屋建, 東寛

日本小児臨床薬理学会雑誌 33 ( 1 ) 32 - 38 2020.12

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Language：Japanese Publisher：日本小児臨床薬理学会

高緯度・寒冷な地理的条件によりビタミンD(VitD)欠乏のリスクが高い北海道道北地域にて、早産児を含む新生児・乳児延べ137名の臍帯血および血清25-hydoroxyvitamin D(25OHD)値を評価し、一部の早産児に対しVitDサプリメントの効果を検討した。早産児60名を含む新生児106名の臍帯血25OHD値は在胎週数、出生体重・プロポーション、季節にかかわらず著しく低値であり、全体の99%が12ng/mL未満の欠乏状態、52%は測定感度未満であった。また生後5ヵ月までの乳児期においても大半がVitD欠乏状態であった。VitD 400単位/日を投与した早産児13例の多くは20ng/mL以上まで上昇したが、3例では十分な上昇がみられなかった。当地域における新生児のVitD欠乏は深刻であり、積極的なVitD投与が必要である。一方、その至適投与量についてはさらなる検討が必要である。(著者抄録)

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Neonatal pleural empyema caused by emm type 6 group A streptococcus. International journal

Fumikatsu Nohara, Ken Nagaya, Hiroko Asai, Etsushi Tsuchida, Toshio Okamoto, Tokitsugi Hayashi, Hiroshi Sakata, Yutaka Terao, Hiroshi Azuma

Pediatrics international : official journal of the Japan Pediatric Society 55 ( 4 ) 519 - 21 2013.8

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Language：English Publishing type：Research paper (scientific journal)

Since the mid-1980s, there have been increasing reports of severe invasive group A streptococcal (GAS) disease in children and adults. There are few reports, however, of neonatal invasive disease, particularly neonatal pleural empyema caused by GAS. Although many mechanisms have been reported for the pathophysiology of invasive GAS infections, similar reports for neonates were unable to be located. Reported herein is the case of a 3-day-old girl with pleural empyema caused by GAS that demonstrated a high invasive capacity for human epithelial cells.

DOI： 10.1111/ped.12061

PubMed

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【周産期医学必修知識(第7版)】新生児編 (Part V) 新生児生理、発達、適応と評価新生児の体温調節

野原史勝, 林時仲

周産期医学 41 ( 増刊 ) 489 - 491 2011.12

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Language：Japanese Publisher：(株)東京医学社

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Research Projects

The relation between thyroid hormone transporter expression in the human placenta and thyroid function of premature infant

Grant number：24791104 2012.4 - 2016.3

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

Nohara Fumikatsu

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Grant amount：\4,030,000 （ Direct Cost: \3,100,000 、 Indirect Cost：\930,000 ）

I investigated the expression of placental transthyretin and MCT8, and thyroid function of a preterm infants. In infants born below 28 weeks' gestation, transient low freeT4 without high TSH was observed, but it recovered naturally until 1 month. The expression of placental MCT8 mRNA was not significant by gestational week, or thyroid function of infant. The expression of placental transthyretin mRNA was decline according to gestational weeks, but the difference was not significant. There is a possibility that it reflect development of infant's thyroid function, but as the number of sample was not sufficient, further investigation will be need.

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