Updated on 2025/08/06

写真a

 
HAYASHI Toshihiko
 
Organization
School of Medicine Medical Course Clinical Medicine Department of Plastiic and Reconstructive Surgery
Homepage
http://kaken.nii.ac.jp/d/r/00432146.ja.html
External link

Degree

  • 医学博士 ( 2006.3   北海道大学 )

Research Interests

  • 共培養

  • ケロイド線維芽細胞

  • 免疫細胞

  • cAMP

  • リンパ節

  • 悪性黒色種

  • 癌転移

  • 悪性黒色腫

  • ケロイド

  • keloid

  • Prostaglandin E2(PGE2)

  • fibrocyte

  • PKA

  • 皮膚癌

  • コラーゲン

  • fibroblast

  • イメージング

  • リンパ行性転移

  • myofibroblast

  • Tリンパ球

  • ケモカイン

  • 転移

  • ヒアルロン酸

  • ブクラデシンナトリウム(DBcAMP)

  • 再生医学

  • ドラッグデリバリーシステム

  • reconstructive surgery

  • lymph flow

Research Areas

  • Life Science / Plastic and reconstructive surgery

  • Life Science / Tumor diagnostics and therapeutics

Education

  • 北海道大学大学院 博士課程

    2002.4 - 2006.3

    　 More details

  • 北海道大学医学部

    1991.4 - 1996.3

    　 More details

  • 北海道大学歯学部

    1989.4 - 1995.4

    　 More details

Research History

  • 旭川医科大学形成・再建外科学講座   教授

    2023.8

    　 More details

  • 旭川医科大学病院形成外科   教授

    2021.1 - 2023.7

    　 More details

  • Hokkaido University   Hokkaido University Hospital

    2018.4 - 2020.12

    　 More details

  • 北海道大学大学院歯学研究院   准教授

    2013.9 - 2020.12

    　 More details

  • Hokkaido University   Hokkaido University Hospital

    2013.9 - 2018.3

    　 More details

  • Hokkaido University   Assistant Professor

    2009.4 - 2013.8

    　 More details

  • 福井大学医学部皮膚科形成外科診療班   助手

    2006.4 - 2007.3

    　 More details

  • 北海道大学形成外科   医員

    1996.4 - 2006.3

    　 More details

▼display all

Papers

  • Physiological and Functional Restoration of the Modiolus Using a Double Tendon Sling in Patients With Full-Thickness Oral Defects. Reviewed International journal

    Taku Maeda, Toshihiko Hayashi, Kosuke Ishikawa, Takahiro Miura, Emi Funayama, Yuhei Yamamoto

    Annals of plastic surgery   94 ( 1 )   70 - 74   2025.1

    　More details

    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Ovid Technologies (Wolters Kluwer Health)  

    Background

    Reconstruction of the oral modiolus should be considered for facial defects involving the lip and cheek. We have performed free flap reconstruction using a novel technique that includes a vertical and a horizontal sling for full-thickness defects involving the oral commissure.

    Patients and Methods

    We used a free radial forearm flap and the palmaris longus tendon to correct lip and cheek defects in 6 patients (3 men, 3 women; age, 55–84 years). The tendon was divided into 2 portions for use as the double sling. One sling was used to connect the upper and lower stumps of the orbicularis oris in the vertical direction and the other to connect the vertical sling and masseter muscle. The outcomes assessed were esthetic appearance and functional results.

    Results

    The facial defects ranged in size from 3.0 cm × 4.0 cm to 7.0 cm × 6.0 cm and the mucosal defects from 1.5 cm × 4.0 cm to 6.5 cm × 5.0 cm. The length of the harvested tendon ranged from 11.5 to 13.5 cm. All flaps survived without complications. Good esthetic outcomes were achieved (excellent facial appearance, n = 1; no lip deviation or drooping, n = 5). Functionally, all patients had acceptable mouth opening and were able to eat a regular diet.

    Conclusions

    Good physiological and functional results can be achieved using a double tendon sling for reconstruction of the modiolus in patients with full-thickness defects involving the oral commissure.

    DOI： 10.1097/SAP.0000000000004129

    PubMed

    researchmap

  • Comparison of leg volume ratio between inguinal lymphadenectomy and inguino-pelvic lymphadenectomy in patients with skin cancer of the lower extremity. Reviewed International journal

    Taku Maeda, Kosuke Ishikawa, Toshihiko Hayashi, Hiroshi Furukawa, Takahiro Miura, Masahiro Hojo, Emi Funayama, Yuhei Yamamoto

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS   99   397 - 405   2024.12

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    BACKGROUND: The timing of intervention to treat lymphedema differs among facilities. Understanding differences in the prevalence and severity of lymphedema following different surgical procedures for lymphadenectomy could promote early intervention to treat lymphedema. There is currently little evidence to support the notion that inguino-pelvic lymphadenectomy is associated with greater morbidity than inguinal lymphadenectomy, although it is believed that the difference in the extent of surgery results in a difference in the severity of lymphedema. In this study, we compared volume percentage change between inguinal lymphadenectomy and inguino-pelvic lymphadenectomy in patients with skin cancer of the lower extremity. PATIENTS AND METHODS: A total of 29 patients with skin cancer of a lower extremity who underwent lymphadenectomy were classified into an inguinal lymphadenectomy group and an inguino-pelvic lymphadenectomy group. The increase in the volume of the affected side compared with that of the unaffected side in the whole lower extremity, thigh, and lower leg was calculated on volume-rendered computed tomography images. RESULTS: The mean volume percentage increase in the inguinal lymphadenectomy group and the inguino-pelvic lymphadenectomy group was, respectively, 6.72% and 11.18% in the whole lower extremity and 7.30% and 2.55% in the lower leg, showing no statistically significant differences. In contrast, the mean volume percentage increase in the respective groups was 7.03% and 19.78% in the thigh, showing a statistically significant difference (p = 0.0275 < 0.05). CONCLUSIONS: The findings of this study indicate that the leg volume of the whole lower extremity may not have worse outcomes in inguino-pelvic lymphadenectomy compared with inguinal lymphadenectomy.

    DOI： 10.1016/j.bjps.2024.10.003

    PubMed

    researchmap

  • 眼窩内に生じた孤立性繊維性腫瘍の治療経験 Reviewed

    宮田 明久生, 林 成司, 西尾 卓哉, 市原 寛大, 宮田 夏実, 山尾 健, 林 利彦

    日本形成外科学会会誌   44 ( 7 )   312 - 321   2024.7

    　More details

    Authorship：Corresponding author  

    researchmap

  • 【それぞれの創傷治癒】瘢痕拘縮における創傷治癒 Reviewed

    林 利彦

    形成外科   67 ( 増刊 )   S12 - S14   2024.6

    　More details

  • Lymphatic drainage patterns of malignant skin tumors in the head and neck region: a single-center retrospective study. Reviewed

    Takuya Nishio, Taku Maeda, Kosuke Ishikawa, Naoki Murao, Kanako Fuyama, Yuhei Yamamoto, Toshihiko Hayashi

    International journal of clinical oncology   29 ( 5 )   582 - 591   2024.5

    　More details

    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: This study aimed to clarify the relationship between primary site and lymphatic drainage pattern for malignant skin tumors in the head and neck region. Malignant melanoma and squamous cell carcinoma in the head and neck region are known to have poor prognosis because of lymph node metastasis. Nevertheless, numerous aspects of lymphatic drainage patterns remain elusive. METHODS: We statistically analyzed data of 47 patients with malignant skin tumors in the head and neck region. Information was collected on the patients' clinical characteristics, primary tumor site, and lymphatic drainage patterns. RESULTS: The parotid lymph nodes drained the greatest amount of lymph from skin tumors of the head and neck. Important lymphatic drainage pathways were the superficial cervical nodes for primary tumors in the buccal/nasal region, level IA and level IB nodes for primary tumors in the lip region, the occipital nodes, posterior auricular nodes, and level VA nodes in the parietal/occipital region, and the preauricular nodes in the auricular region. CONCLUSION: These findings have considerable significance in terms of understanding lymphatic drainage patterns for malignant skin tumors in the head and neck and may be useful for clinical decision-making and when planning treatment. Further research and clinical applications are expected to contribute to an improved prognosis in patients with cutaneous head and neck malignancies.

    DOI： 10.1007/s10147-024-02487-2

    PubMed

    researchmap

  • Restoration of lymph flow by flap transfer can prevent severe lower extremity lymphedema after inguino-pelvic lymphadenectomy. Reviewed

    Taku Maeda, Yuhei Yamamoto, Toshihiko Hayashi, Hiroshi Furukawa, Kosuke Ishikawa, Takahiro Miura, Masahiro Hojo, Emi Funayama

    Surgery today   53 ( 5 )   588 - 595   2023.5

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    PURPOSE: Severe lymphedema is difficult to treat because of the associated extensive scar formation. Therefore, preventing scar formation might alleviate the severity of lymphedema following lymphadenectomy. In this study, we evaluated the usefulness of flap transfer, performed immediately after lymphadenectomy, for preventing scar formation. METHODS: Twenty-three patients with subcutaneous malignancy in a lower extremity, who underwent inguino-pelvic lymphadenectomy, were divided into groups based on whether flap transfer was performed. The severity of lymphedema was categorized according to the ratio of the circumference of the affected extremity to that of the unaffected extremity, as mild (< 20% increase in volume), moderate (20-40%), or severe (> 40%). RESULTS: In the 18 patients who underwent lymphadenectomy without flap transfer, lymphedema was classified as mild in 7, moderate in 7, and severe in 4. In the five patients who underwent lymphadenectomy with flap transfer, lymphedema was classified as mild in 4 and moderate in 1. This difference between the groups did not reach significance. CONCLUSIONS: The findings of this study suggest that flap transfer may help prevent scar formation and contribute to the restoration of lymph flow after lymphadenectomy.

    DOI： 10.1007/s00595-022-02608-2

    PubMed

    researchmap

    Other Link： https://link.springer.com/article/10.1007/s00595-022-02608-2/fulltext.html

  • Refinements in the reconstruction of bisphosphonate-related osteonecrosis of the jaw. Reviewed International journal

    Taku Maeda, Yuhei Yamamoto, Akira Satoh, Toshihiko Hayashi

    JPRAS open   35   1 - 5   2023.3

    　More details

    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    The recommended treatment strategy for stage 3 bisphosphonate-related osteonecrosis of the jaw (BRONJ) is currently rigid plate fixation without bone reconstruction. However, a recent systematic review indicated the utility of microsurgical reconstruction after resection of BRONJ. Several types of flaps have been described but their applications are controversial. Here we present a detailed reconstruction plan for obtaining better outcomes in patients with maxillary and mandibular BRONJ. Given that progressive maxillary BRONJ is often invasive to the skin, including the eyelid, leading to functional loss such as leakage of discharge and ectropion, several revision surgeries are needed to increase the volume in the defect after the free flap transfer. For progressive mandibular BRONJ, hemi-mandibulectomy to subtotal mandibulectomy with an adequate margin from the necrotic bone is necessary, followed by a well-designed fibular free flap.

    DOI： 10.1016/j.jpra.2022.11.004

    PubMed

    researchmap

  • 前額部隆起性皮膚線維肉腫の治療経験 Reviewed

    宮田夏実, 西尾卓哉, 市原寛大, 宮田明久生, 山尾健, 湯澤明夏, 林 利彦

    日本形成外科学会会誌   2023

    　More details

    Authorship：Corresponding author   Language：Japanese   Publishing type：Research paper (scientific journal)  

    researchmap

  • 皮膚悪性腫瘍患者へ最良の再建を行うために〜基本の整理

    古川洋志, 林 利彦, 山本有平

    Skin Cancer   2023

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)  

    researchmap

  • チームサージャリーにおける形成外科の貢献 新型コロナウイルス感染症が及ぼした影響 Reviewed

    松田 識郁, 石川 耕資, 前田 拓, 大澤 昌之, 舟山 恵美, 村尾 尚規, 林 利彦, 山本 有平

    日本形成外科学会会誌   42 ( 7 )   369 - 374   2022.7

    　More details

    Language：Japanese   Publisher：(一社)日本形成外科学会  

    researchmap

  • 大臀筋弁を用いて再建した仙骨浸潤を伴う熱傷瘢痕癌の1例 Reviewed

    石井 陸, 前田 拓, 石川 耕資, 山尾 健, 山本 有平, 林 利彦

    創傷   13 ( 3 )   118 - 123   2022.7

    　More details

    Language：Japanese   Publisher：(一社)日本創傷外科学会  

    researchmap

  • リンパ節移植という局所外科的リンパ系再構築法がもたらす可能性 循環と免疫の観点から

    前田 拓, 石川 耕資, 村尾 尚規, 林 利彦, 古川 洋志, 舟山 恵美, 大澤 昌之, 山本 有平

    リンパ学   45 ( 1 )   38 - 41   2022.6

    　More details

    Language：Japanese   Publisher：日本リンパ学会  

    researchmap

  • 遊離空腸再建における合併症早期発見のためのカラーエコーの有用性について Reviewed

    前田 拓, 林 利彦, 石川 耕資, 北條 正洋, 舟山 恵美, 三浦 隆洋, 山本 有平

    頭頸部癌   48 ( 2 )   180 - 180   2022.5

    　More details

    Language：Japanese   Publisher：(一社)日本頭頸部癌学会  

    researchmap

  • 肺および大腿骨に遠隔転移を来した頭部巨大基底細胞癌の治療経験 Reviewed

    北條 正洋, 前田 拓, 林 利彦, 山本 有平

    頭頸部癌   48 ( 2 )   230 - 230   2022.5

    　More details

    Language：Japanese   Publisher：(一社)日本頭頸部癌学会  

    researchmap

  • 頸部リンパ節郭清後の肥厚性瘢痕・ケロイドについての分析

    前田 拓, 林 利彦, 村尾尚規, 山本 有平

    瘢痕ケロイド治療ジャーナル.   2022

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)  

    researchmap

  • Gracilis muscle flap combined with a laparoscopic transabdominal approach is effective in the treatment of post-prostatectomy rectourethral fistula: A case report. Reviewed

    Takeda T., Shonaka T., Tani C., Hayashi T., Kakizaki H., Sumi Y.

    Int J Surg Case Rep   2022

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    researchmap

  • マイクロサージャリーにおける経済・QOL評価 頭頸部再建チームサージャリーにおけるマイクロサージャリーの経済的貢献

    石川 耕資, 前田 拓, 古川 洋志, 林 利彦, 村尾 尚規, 松田 識郁, 三浦 隆洋, 北條 正洋, 山本 有平

    日本マイクロサージャリー学会学術集会プログラム・抄録集   48回   286 - 286   2021.12

    　More details

    Language：Japanese   Publisher：(一社)日本マイクロサージャリー学会  

    researchmap

  • 遊離腓骨弁と大胸筋皮弁を併用した下顎骨の一期的再建治療

    西尾 卓哉, 林 利彦, 山尾 健, 市原 寛大, 山本 有平

    日本マイクロサージャリー学会学術集会プログラム・抄録集   48回   319 - 319   2021.12

    　More details

    Language：Japanese   Publisher：(一社)日本マイクロサージャリー学会  

    researchmap

  • マイクロサージャリーを用いた頭頸部再建後の長期経過-下顎再建 下顎骨再建における遊離腓骨移植後の骨吸収に関する長期経過の検討

    林 利彦, 山尾 健, 西尾 卓哉, 市原 寛大, 前田 拓, 石川 耕資

    日本マイクロサージャリー学会学術集会プログラム・抄録集   48回   260 - 260   2021.12

    　More details

    Language：Japanese   Publisher：(一社)日本マイクロサージャリー学会  

    researchmap

  • マイクロサージャリー術後合併症予防への工夫・対応 遊離空腸再建における術後合併症のリスク回避と早期対応のわれわれの取り組み

    前田 拓, 林 利彦, 石川 耕資, 北條 正洋, 山本 有平

    日本マイクロサージャリー学会学術集会プログラム・抄録集   48回   277 - 277   2021.12

    　More details

    Language：Japanese   Publisher：(一社)日本マイクロサージャリー学会  

    researchmap

  • Combined internal and external negative pressure wound therapy: breakthrough treatment for lymphocutaneous intractable fistula. Reviewed

    Takahiro Miura, Yuhei Yamamoto, Naoki Murao, Taku Maeda, Masayuki Osawa, Toshihiko Hayashi, Emi Funayama

    Surgery today   51 ( 10 )   1630 - 1637   2021.10

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    PURPOSE: Lymphocutaneous fistula after lymph node dissection is intractable, yet there is no established treatment strategy. This study demonstrates the wound closure time achieved by a new method of combined internal and external negative pressure wound therapy (CIEN) in patients with lymphocutaneous fistula. METHODS: The subjects of this study were six consecutive patients with lymphocutaneous fistula after lymphatic surgery, who were treated with CIEN between 2018 and 2020. The CIEN technique can be summarized as follows: first, internal foam is inserted into the fistula from the opening of the fenestration. Next, a slightly larger area of external foam is applied above the fistula flap outside the external margin of the foam-filled fistula. After bridging the internal foam and external foam, negative-pressure wound therapy is carried out on this bridging foam block. RESULTS: CIEN led to rapid and complete wound healing in all six patients. Fistula flap margin ischemia developed in one patient, but adjusting the mode and pressure settings resulted in improvement. Three patients suffered contact dermatitis. There were no signs of tumor or fistula recurrence in any patients after at least 3 months of follow-up. CONCLUSION: CIEN is an effective and less invasive treatment modality than the conventional method of managing lymphocutaneous fistula.

    DOI： 10.1007/s00595-021-02283-9

    PubMed

    researchmap

    Other Link： https://link.springer.com/article/10.1007/s00595-021-02283-9/fulltext.html

  • Temporoparietal fascia flap was useful for the open surgery of temporomandibular joint mobilization Reviewed

    Hiroyuki Hato, Noritaka Ohga, Chiharu Satoh, Ken-ichiro Sakata, Takuya Asaka, Taku Maeda, Taihiko Yamaguhi, Toshihiko Hayashi, Yoshimasa Kitagawa

    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology   2021.10

    　More details

    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.ajoms.2021.08.001

    researchmap

  • 遊離広背筋弁で再建した頭蓋骨に及ぶIII度熱傷の1例 Reviewed

    竹田 朋弘, 石川 耕資, 林 利彦, 前田 拓, 石井 陸, 佐々木 雄輝, 北條 正洋, 三浦 隆洋, 大澤 昌之, 舟山 恵美, 山本 有平

    熱傷   47 ( 3 )   114 - 121   2021.9

    　More details

  • リンパ浮腫に対する最新研究と治療戦略 マウスリンパ節移植モデル リンパ節移植の循環系・免疫系作用に関する基礎研究

    石川 耕資, 前田 拓, 草島 英梨香, 舟山 恵美, 林 利彦, 大澤 昌之, 古川 洋志, 山本 有平

    リンパ学   44 ( 1 )   24 - 27   2021.7

    　More details

    Language：Japanese   Publisher：日本リンパ学会  

    researchmap

  • ケロイド・肥厚性瘢痕の集学的予防と治療 ケロイド・肥厚性瘢痕の集学的治療と再発制御

    村尾 尚規, 林 利彦, 前田 拓, 山本 有平

    瘢痕・ケロイド治療ジャーナル   ( 15 )   1 - 3   2021.7

    　More details

    Language：Japanese   Publisher：(株)全日本病院出版会  

    researchmap

  • リンパ浮腫に対する最新研究と治療戦略 マウスリンパ節移植モデル リンパ節移植の循環系・免疫系作用に関する基礎研究

    石川 耕資, 前田 拓, 草島 英梨香, 舟山 恵美, 林 利彦, 大澤 昌之, 古川 洋志, 山本 有平

    リンパ学   44 ( 1 )   24 - 27   2021.7

    　More details

    Language：Japanese   Publisher：日本リンパ学会  

    researchmap

  • Clinical study of treatment methods and associated factors in mandibular osteoradionecrosis. Reviewed

    Hiroyuki Hato, Ken-Ichiro Sakata, Jun Sato, Akira Satoh, Toshihiko Hayashi, Yoshimasa Kitagawa

    Journal of oral science   63 ( 3 )   289 - 291   2021.6

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.2334/josnusd.21-0154

    Web of Science

    Scopus

    PubMed

    researchmap

  • Topical Application of Conditioned Medium from Hypoxically Cultured Amnion-Derived Mesenchymal Stem Cells Promotes Wound Healing in Diabetic Mice. Reviewed International journal

    Hiroko Takahashi, Shunsuke Ohnishi, Yuhei Yamamoto, Toshihiko Hayashi, Naoki Murao, Masayuki Osawa, Taku Maeda, Kosuke Ishikawa, Naoya Sakamoto, Emi Funayama

    Plastic and reconstructive surgery   147 ( 6 )   1342 - 1352   2021.6

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Mesenchymal stem cells or their conditioned medium improve chronic wound healing, and their effect is enhanced by hypoxia. Diabetic foot ulcers are chronic wounds characterized by abnormal and delayed healing, which frequently require amputation. The authors evaluated the effect of topical application of conditioned medium from hypoxically cultured amnion-derived mesenchymal stem cells on wound healing in diabetic mice. METHODS: Amnion-derived mesenchymal stem cells were cultured under 21% oxygen to prepare normoxic conditioned medium and under 1% oxygen to prepare hypoxic conditioned medium. Hydrogels containing standard medium, normoxic conditioned medium, or hypoxic conditioned medium were topically applied to excisional wounds of mice with streptozotocin-induced diabetes. Ulcer tissues were harvested on day 9; immunohistochemical and quantitative polymerase chain reaction analyses were performed to analyze angiogenesis, inflammatory cell infiltration, and expression levels of inflammation-related genes. RESULTS: Hypoxic conditioned medium significantly enhanced wound closure, increased capillary density and epithelization, and reduced macrophage infiltration. It also tended to reduce the infiltration of neutrophils and enhance the infiltration of regulatory T cells; it showed a tendency to downregulate the expression of the inflammation-related genes interleukin-1β, interleukin-6, chemokine ligand 1, and chemokine ligand 2. Normoxic conditioned medium exhibited similar effects, although they were of lesser magnitude than those of hypoxic conditioned medium. CONCLUSIONS: Hydrogels containing hypoxically cultured, amnion-derived mesenchymal stem cell conditioned medium accelerated wound healing in diabetic mice by enhancing angiogenesis, accelerating epithelization, and suppressing inflammation. Therefore, topical application of amnion mesenchymal stem cell-derived hypoxic conditioned medium could be a novel treatment for diabetic foot ulcers.

    DOI： 10.1097/PRS.0000000000007993

    PubMed

    researchmap

  • 遊離広背筋弁による再建を要した頭部III度熱傷の1例

    竹田 朋弘, 石川 耕資, 林 利彦, 前田 拓, 伊藤 梨里, 北條 正洋, 石井 陸, 佐々木 雄輝, 山本 有平

    熱傷   47 ( 1 )   36 - 36   2021.3

    　More details

    Language：Japanese   Publisher：(一社)日本熱傷学会  

    researchmap

  • Iatrogenic third-degree burn caused by off-label use of an infrared radiant heat lamp in a patient with accidental hypothermia Reviewed

    Kosuke Ishikawa, Taku Maeda, Toshihiko Hayashi, Ryuji Shichinohe, Naoki Murao, Masahiro Hojo, Riri Ito, Masayuki Osawa, Yuhei Yamamoto, Emi Funayama

    Burns Open   5 ( 1 )   21 - 24   2021.1

    　More details

    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.burnso.2020.09.001

    researchmap

  • 悪性黒色腫の切除から再建まで―新しい薬物療法と外科手術のコラボレーションー Invited

    林 利彦, 前田 拓, 山本有平

    Skin Cancer   2021

    　More details

    Authorship：Lead author   Language：Japanese   Publishing type：Research paper (scientific journal)  

    researchmap

  • Maggot debridement therapy in critical limb ischaemia: a case study. Reviewed International journal

    Taku Maeda, Yuhei Yamamoto, Naoki Murao, Toshihiko Hayashi, Chu Kimura, Suguru Matsui, Tatsuya Saito, Hotaka Matsui, Masayuki Osawa, Emi Funayama

    Journal of wound care   29 ( Sup12 )   S28-S32   2020.12

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    OBJECTIVE: In critical limb ischaemia (CLI), first-line therapy is revascularisation, but alternative treatment options are needed in certain cases. Maggot debridement therapy (MDT) is historically considered to be contraindicated in ischaemic ulcers. Wound care in patients with CLI is becoming increasingly diverse with the development of novel revascularisation strategies; therefore, CLI now needs to be reconsidered as an indication for MDT. METHOD: We retrospectively reviewed five legs with CLI (five male, one female) treated with MDT between January 2013 and December 2017. Changes in skin perfusion pressure (SPP) around the ulcer before and after MDT were evaluated. One or two cycles of MDT were performed (eight in total). We also evaluated the proportion of necrotic tissue in the ulcer and the presence of exposed necrotic bone. The proportion of necrotic tissue in the ulcer was classified as NT 1+ (<25%), NT 2+ (25-50%), NT 3+ (50-75%) or NT 4+ (>75%). RESULTS: When the proportion of necrotic tissue was >50%, with no exposed necrotic bone in the wound, an increase in SPP was observed after five (62.5%) of eight cycles of MDT. And with a proportion of necrotic tissue of <25% and/or exposed necrotic bone in the wound, a decrease in SPP was observed after three (37.5%) of eight cycles. Wound healing was accelerated in the presence of increased SPP. CONCLUSION: Effective MDT with increased SPP requires an ulcerative state of necrotic tissue grade > NT 3+, with no exposed necrotic bone.

    DOI： 10.12968/jowc.2020.29.Sup12.S28

    PubMed

    researchmap

  • 【私の流儀】舌下神経をモーターソースとした神経移行術による顔面神経麻痺再建の歴史

    古川 洋志, 安村 恒央, 田中 真美, 梅本 泰孝, 前田 拓, 七戸 龍司, 大澤 昌之, 林 利彦, 山本 有平

    日本頭蓋顎顔面外科学会誌   36 ( 4 )   149 - 153   2020.12

    　More details

  • 頭皮原発血管肉腫に対する化学療法および強度変調放射線照射による集学的治療の有用性

    前田 拓, 北條 正洋, 林 利彦, 山本 有平, 安田 耕一

    日本皮膚悪性腫瘍学会学術大会プログラム・抄録集   36回   153 - 153   2020.12

    　More details

    Language：Japanese   Publisher：(一社)日本皮膚悪性腫瘍学会  

    researchmap

  • Long-term outcomes and recurrence-free interval after the treatment of keloids with a standardized protocol. Reviewed International journal

    T Maeda, E Funayama, Y Yamamoto, N Murao, M Osawa, K Ishikawa, T Hayashi

    Journal of tissue viability   2020.11

    　More details

    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Recurrence rates of keloids have generally been reported at one time point. However, the longer the duration after treatment, the greater the likelihood that such lesions will recur. In this study, we analysed the time to recurrence during long-term follow-up. MATERIAL AND METHODS: We retrospectively reviewed recurrence-free interval in 52 patients with keloid (age 8-79 years) who had been treated between June 2006 and January 2011 using a standardised protocol developed by our group. RESULTS: Mean duration of follow-up was 37.5 (range, 7-120) months in patients with keloid. Kaplan-Meier survival curves revealed a statistically significant difference in recurrence-free interval between ear keloids and keloids excluding ear keloids. Recurrence rate for keloids was high in the first 2 years after treatment. CONCLUSIONS: Kaplan-Meier analysis was useful for understanding the tendency of recurrence of keloids after treatment using a standardised protocol.

    DOI： 10.1016/j.jtv.2020.11.003

    PubMed

    researchmap

  • A Comparison of Outcomes After Palatoplasty in Patients With Non-Syndromic Pierre Robin Sequence Versus Patients With Non-Syndromic Isolated Cleft Palate

    Maeda Taku, Yuhei Yamamoto, Akihiko Oyama, Satoru Sasaki, Toshihiko Hayashi, Naoki Murao, Masayuki Osawa, Emi Funayama

    The Journal of craniofacial surgery   31 ( 8 )   2231 - 2234   2020.11

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：NLM (Medline)  

    The purpose of this retrospective study was to compare outcomes of cleft palate repair in patients with non-syndromic Pierre Robin sequence (NS-PRS) versus those with non-syndromic isolated cleft palate (NS-ICP). Pierre Robin sequence (PRS) was defined as a diagnosis of the triad of microretrognathia, glossoptosis, and cleft palate, and the severity of PRS was assessed based on the presence of respiratory and feeding problems. All patients underwent palatoplasty between January 2000 and December 2011. The authors examined age at palatoplasty, type of cleft palate, fistula rate, velopharyngeal (VP) function, nasal emission, hypernasality, and need for secondary speech surgery, in addition to PRS severity in the NS-PRS patients. A total of 15 NS-PRS patients and 40 NS-ICP patients were reviewed. The incidence of VP dysfunction, nasal emission, hypernasality, and secondary speech surgery was not significantly different between the NS-PRS patients and NS-ICP patients. Age at palatoplasty was significantly different between the 2 groups (P = 0.012) but type of CP was not (P = 1.00). Only 2 NS-PRS patients were classified as category III (severe), and all of the NS-PRS patients who had VP insufficiency were classified as PRS severity category I (not severe). The findings of this study indicate that NS-PRS patients may not have worse outcomes than NS-ICP patients.

    DOI： 10.1097/SCS.0000000000006672

    Scopus

    PubMed

    researchmap

  • A Comparison of Outcomes After Palatoplasty in Patients With Non-Syndromic Pierre Robin Sequence Versus Patients With Non-Syndromic Isolated Cleft Palate. International journal

    Maeda Taku, Yuhei Yamamoto, Akihiko Oyama, Satoru Sasaki, Toshihiko Hayashi, Naoki Murao, Masayuki Osawa, Emi Funayama

    The Journal of craniofacial surgery   2020.10

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    The purpose of this retrospective study was to compare outcomes of cleft palate repair in patients with non-syndromic Pierre Robin sequence (NS-PRS) versus those with non-syndromic isolated cleft palate (NS-ICP). Pierre Robin sequence (PRS) was defined as a diagnosis of the triad of microretrognathia, glossoptosis, and cleft palate, and the severity of PRS was assessed based on the presence of respiratory and feeding problems. All patients underwent palatoplasty between January 2000 and December 2011. The authors examined age at palatoplasty, type of cleft palate, fistula rate, velopharyngeal (VP) function, nasal emission, hypernasality, and need for secondary speech surgery, in addition to PRS severity in the NS-PRS patients. A total of 15 NS-PRS patients and 40 NS-ICP patients were reviewed. The incidence of VP dysfunction, nasal emission, hypernasality, and secondary speech surgery was not significantly different between the NS-PRS patients and NS-ICP patients. Age at palatoplasty was significantly different between the 2 groups (P = 0.012) but type of CP was not (P = 1.00). Only 2 NS-PRS patients were classified as category III (severe), and all of the NS-PRS patients who had VP insufficiency were classified as PRS severity category I (not severe). The findings of this study indicate that NS-PRS patients may not have worse outcomes than NS-ICP patients.

    DOI： 10.1097/SCS.0000000000006672

    PubMed

    researchmap

  • Ulcerated Infantile Hemangioma of the Hard Palate: Diagnostic Treatment With Oral Propranolol

    Kosuke Ishikawa, Munezumi Fujita, Tomohiro Takeda, Shintaro Mitamura, Takuya Nishio, Emi Funayama, Toshihiko Hayashi, Masayuki Osawa, Taku Maeda, Yuhei Yamamoto, Satoru Sasaki

    The Journal of craniofacial surgery   31 ( 6 )   e600 - e602   2020.9

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：NLM (Medline)  

    Infantile hemangiomas arising in the palate are rare. The authors describe a case of ulcerated infantile hemangioma of the hard palate with feeding difficulty. To our knowledge, this is the first reported case of immunohistochemically diagnosed palatal infantile hemangioma successfully treated using oral propranolol.

    DOI： 10.1097/SCS.0000000000006666

    Scopus

    PubMed

    researchmap

  • ケロイド組織で炎症が遷延するメカニズム 炎症性サイトカインIL-6とCD4陽性T細胞のケロイド線維芽細胞に対する作用

    村尾 尚規, 藤田 宗純, 林 利彦, 清野 研一郎, 村上 正晃, 山本 有平

    瘢痕・ケロイド治療ジャーナル   ( 14 )   4 - 6   2020.9

    　More details

    Language：Japanese   Publisher：(株)全日本病院出版会  

    researchmap

  • 高齢者の上眼瞼全層再建 前進皮弁と裏打ち移植の検討

    池田 正起, 林 利彦, 伊藤 梨里

    日本形成外科学会会誌   40 ( 8 )   431 - 431   2020.8

    　More details

    Language：Japanese   Publisher：(一社)日本形成外科学会  

    researchmap

  • 頭皮原発血管肉腫に対する強度変調放射線照射(IMRT)の有用性

    前田 拓, 林 利彦, 北條 正洋, 山本 有平

    頭頸部癌   46 ( 2 )   166 - 166   2020.7

    　More details

    Language：Japanese   Publisher：(一社)日本頭頸部癌学会  

    researchmap

  • SLN陰性後早期に顎下に転移をきたした右口角Merkel細胞癌の治療経験

    西尾 卓哉, 林 利彦, 前田 拓, 村尾 尚規, 山本 有平

    頭頸部癌   46 ( 2 )   183 - 183   2020.7

    　More details

    Language：Japanese   Publisher：(一社)日本頭頸部癌学会  

    researchmap

  • カルシフィラキシーに対する創部ケア 周期的持続灌流を併用した陰圧閉鎖療法による新規アプローチ法(Wound Care for Calciphylaxis: A Novel Approach for Wound Management with Negative Pressure Wound Therapy with Instillation and Dwell Time) Reviewed

    Guilpain Kusajima Erika, Yamamoto Yuhei, Murao Naoki, Hayashi Toshihiko, Osawa Masayuki, Maeda Taku, Ishikawa Kosuke, Horiuchi Katsumi, Matsui Suguru, Saito Tatsuya, Matsui Hotaka, Funayama Emi

    International Journal of Surgical Wound Care   1 ( 1 )   20 - 26   2020.6

    　More details

    Language：English   Publisher：(一社)日本創傷外科学会  

    researchmap

  • Wound Care for Calciphylaxis

    Erika Guilpain Kusajima, Yuhei Yamamoto, Naoki Murao, Toshihiko Hayashi, Masayuki Osawa, Taku Maeda, Kosuke Ishikawa, Katsumi Horiuchi, Suguru Matsui, Tatsuya Saito, Hotaka Matsui, Emi Funayama

    International Journal of Surgical Wound Care   1 ( 1 )   20 - 26   2020

    　More details

    Publishing type：Research paper (scientific journal)   Publisher：Japan Society for Surgical Wound Care  

    DOI： 10.36748/ijswc.1.1_20

    researchmap

  • Application of Negative-pressure Wound Therapy after Radical Excision of Soft Tissue Malignancy

    Taku Maeda, Naoki Murao, Toshihiko Hayashi, Emi Funayama, Masayuki Osawa, Kosuke Ishikawa, Yuhei Yamamoto

    International Journal of Surgical Wound Care   1 ( 2 )   47 - 52   2020

    　More details

    Publishing type：Research paper (scientific journal)   Publisher：Japan Society for Surgical Wound Care  

    DOI： 10.36748/ijswc.1.2_47

    researchmap

  • Combination laser therapy as a non-surgical method for treating congenital melanocytic nevi from cosmetically sensitive locations on the body. Reviewed International journal

    Emi Funayama, Yuhei Yamamoto, Akihiko Oyama, Naoki Murao, Toshihiko Hayashi, Taku Maeda, Hiroshi Furukawa, Masayuki Osawa

    Lasers in medical science   34 ( 9 )   1925 - 1928   2019.12

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s10103-019-02753-0

    PubMed

    researchmap

  • Squamous cell carcinoma arising in a chronic leg ulcer in Klippel-Trenaunay syndrome after the Charles procedure: A case with 40 years of follow up. Reviewed International journal

    Kosuke Ishikawa, Emi Funayama, Yuhei Yamamoto, Hiroshi Furukawa, Toshihiko Hayashi, Naoki Murao, Masayuki Osawa, Taku Maeda, Munezumi Fujita, Satoru Sasaki

    The Journal of dermatology   46 ( 11 )   e403-e405 - e405   2019.11

    　More details

  • Advancement Flap Using Excess Skin for Upper Eyelid Full-Thickness Defects. Reviewed International journal

    Riri Ito, Taku Maeda, Yuhei Yamamoto, Emi Funayama, Naoki Murao, Masayuki Osawa, Kosuke Ishikawa, Masaki Ikeda, Toshihiko Hayashi

    The Journal of craniofacial surgery   30 ( 8 )   2614 - 2616   2019.11

    　More details

    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    Reconstruction of upper eyelid defects should aim for a moveable lid with perfect corneal protection and good aesthetic quality. Numerous procedures to reconstruct large upper eyelid defects have been reported, but these methods require 2-stage procedures. A new method for reconstructing full-thickness upper eyelid defects after tumor excision in a single stage was presented in this study. The preferred technique uses excess skin as an advancement flap together with an ear cartilage graft for the lining. Reconstruction was performed with an advancement flap using excess skin and ear cartilage for full-thickness defects after upper eyelid tumor excision. The rectangular flap was outlined on the excess skin of the upper eyelid. After tumor resection of the full-thickness defect, the ear cartilage was sutured to the remaining tarsus. The residual levator aponeurosis and posterior lamellar were connected to the transplanted ear cartilage. The outer layer was reconstructed with an advancement rectangular flap. The authors performed this technique for 4 patients, aged 62 to 88 years, for upper eyelid reconstruction. Good functional and aesthetic results were achieved for all patients. Our method involves a single-stage reconstruction, which is simpler and less invasive than other techniques.

    DOI： 10.1097/SCS.0000000000005944

    PubMed

    researchmap

  • 先天性顔面神経麻痺に対するネットワーク型神経再建を行った1例

    古川 洋志, 山本 有平, 前田 拓, 林 利彦, 大澤 昌之, 舟山 恵美, 七戸 龍司

    日本頭蓋顎顔面外科学会誌   35 ( 3 )   84 - 88   2019.9

    　More details

  • Oculo-Auriculo-Fronto-Nasal Syndrome With Duane Retraction Syndrome and Dysplastic Bony Structure in the Midline of Nose. Reviewed International journal

    Riri Ito, Masayuki Osawa, Yuhei Yamamoto, Naoki Murao, Toshihiko Hayashi, Taku Maeda, Kosuke Ishikawa, Akihiko Oyama, Emi Funayama

    The Journal of craniofacial surgery   30 ( 6 )   e576-e578 - e578   2019.9

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Oculo-auriculo-fronto-nasal syndrome (OAFNS) is a rare anomaly characterized by features overlapping those of frontonasal dysplasia (FND) and the oculo-auriculo-vertebral spectrum (OAVS).1 The FND features malformation of frontonasal process-derived structures, characterized by anomalies in the central portion of the face. The OAVS is characterized by developmental anomalies of the first and second pharyngeal arches. The OAFNS is a condition with clinical features of both FND and OAVS. Here, the authors present the case of a male with OAFNS who not only exhibited typical OAFNS symptoms but also a dysplastic bony structure that bridged the anterior nasal spine and inferior nasal bones, and unilateral type 3 Duane retraction syndrome (absence of right-eye abduction). Abnormal nasal bones are characteristic of OAFNS; such abnormalities are absent from FND and OAVS. The authors reduced the dysplastic nasal bony structure via open external rhinoplasty, followed by lateral nasal osteotomy when he was 16 years of age. The nasal dorsum appeared natural after surgery and he was satisfied with the result.

    DOI： 10.1097/SCS.0000000000005636

    PubMed

    researchmap

  • New video fluoroscopic chewing examination for patients who use dentures after mandibular reconstruction. Reviewed International journal

    T Hayashi, K Kuribayashi, T Maeda, Y Yamamoto

    The British journal of oral & maxillofacial surgery   57 ( 7 )   697 - 698   2019.9

    　More details

    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.bjoms.2019.05.014

    PubMed

    researchmap

  • 創傷部蝿蛆症の1経験

    南本 俊之, 大石 佳織, 和田 真由美, 長田 敬子, 石川 耕資, 林 利彦

    函館医学誌   43 ( 1 )   20 - 23   2019.9

    　More details

  • Facklamia hominisによる皮下膿瘍の1経験

    南本 俊之, 佐藤 多嘉之, 小林 延行, 池町 香澄, 杉本 隆幸, 菅原 拓美, 本田 進, 石川 耕資, 村尾 尚紀, 林 利彦

    Skin Surgery   28 ( 2 )   108 - 111   2019.6

    　More details

  • Chondrocutaneous Bilateral Advancement Flap with Postoperative Radiation Therapy for a Helical Rim Keloid. Reviewed International journal

    Taku Maeda, Toshihiko Hayashi, Naoki Murao, Yuhei Yamamoto

    Aesthetic plastic surgery   43 ( 3 )   658 - 662   2019.6

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Keloids can be recalcitrant, and a well-planned treatment strategy is essential. Multiple ear piercings have recently become popular, particularly among younger age groups. Management of keloids that develop after piercing of the ear cartilage may be particularly problematic. Helical rim keloids are difficult to excise because of the complex, three-dimensional, cartilaginous structure of the helix and its thin and tightly adherent covering layer of skin. The chondrocutaneous advancement flap introduced by Antia and Buch may be a useful reconstructive option for a helical rim keloid after marginal loss of a segment of the helix as a result of trauma, a burn, or excision of a malignant tumor. However, this technique is limited to wounds that involve only the helix. In this technical note, we describe the use of a chondrocutaneous bilateral advancement flap with postoperative radiation therapy to treat a more invasive and relatively large keloid on the scapha. This technique is straightforward and safe in terms of preserving the blood supply. The addition of adjuvant radiation therapy can help to decrease the risk of recurrence and preserve the morphological structure of the ear and patient satisfaction.Level of Evidence IV This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

    DOI： 10.1007/s00266-019-01321-9

    PubMed

    researchmap

  • Changes in high endothelial venules in lymph nodes after vascularized and nonvascularized lymph node transfer in a murine autograft model. Reviewed International journal

    Kosuke Ishikawa, Emi Funayama, Taku Maeda, Toshihiko Hayashi, Naoki Murao, Masayuki Osawa, Riri Ito, Hiroshi Furukawa, Akihiko Oyama, Yuhei Yamamoto

    Journal of surgical oncology   119 ( 6 )   700 - 707   2019.5

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND AND OBJECTIVES: Vascularized lymph node transfer (LNT) is gaining popularity in the treatment of lymphedema. However, it is unclear whether the vascularization of transferred lymph nodes (LNs) contributes to functional improvement. High endothelial venules (HEVs) are specialized vessels that allow lymphocytes to enter LNs. In this study, we compared the numbers of HEVs and lymphocytes in LNs after vascularized and nonvascularized LNT. METHODS: Fifty mice were divided into three groups (group 1, pedicled vascularized LNT; group 2, pedicled nonvascularized LNT; group 3, free nonvascularized LNT). Afferent lymphatic reconnection was confirmed by patent blue staining. The transferred LNs were harvested 4 weeks after surgery. HEVs, B-cells, and T-cells were subjected to immunohistochemical staining and quantified. RESULTS: Afferent lymphatic reconnection was observed in 13 of 20 transferred LNs in group 1, 11 of 15 in group 2, and 7 of 15 in group 3. The ratio of dilated/total HEVs in transferred LNs with afferent lymphatic reconnection was significantly higher in group 1 than in groups 2 and 3. No significant differences in numbers of B-cells and T-cells were found in the transferred LNs. CONCLUSIONS: We found that more functional HEVs were preserved in cases with successful afferent lymphatic reconnection after vascularized LNT than after nonvascularized LNT.

    DOI： 10.1002/jso.25365

    PubMed

    researchmap

  • Feasibility of pedicled vascularized inguinal lymph node transfer in a mouse model: A preliminary study. Reviewed International journal

    Kosuke Ishikawa, Taku Maeda, Emi Funayama, Toshihiko Hayashi, Naoki Murao, Masayuki Osawa, Hiroshi Furukawa, Akihiko Oyama, Yuhei Yamamoto

    Microsurgery   39 ( 3 )   247 - 254   2019.3

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    PURPOSE: Vascularized lymph node transfer is becoming more common in the treatment of lymphedema, but suitable small animal models for research are lacking. Here, we evaluated the feasibility of pedicled vascularized inguinal lymph node transfer in mice. METHODS: Twenty-five mice were used in the study. An inguinal lymph node-bearing flap with a vascular pedicle containing the superficial caudal epigastric vessels was transferred into the ipsilateral popliteal fossa after excision of the popliteal lymph node. Indocyanine green (ICG) angiography was used to confirm vascularity of the flap. ICG lymphography was performed to evaluate lymphatic flow at 3 and 4 weeks postoperatively. Patent blue dye was injected into the ipsilateral hind paw to observe staining of the transferred lymph node at 4 weeks postoperatively. All transferred lymph nodes were then harvested and histologically evaluated by hematoxylin and eosin staining. RESULTS: In 16 of the 25 mice, ICG lymphography showed reconnection between the transferred lymph node and the afferent lymphatic vessels, as confirmed by patent blue staining. Histologically, these transferred lymph nodes with afferent lymphatic reconnection significantly regressed in size (0.37 ± 0.24 mm2 ) and showed clear follicle formation, whereas those without afferent lymphatic reconnection showed less size regression (1.31 ± 1.17 mm2 ); the cell population was too dense to allow identification of follicles. CONCLUSIONS: We established a mouse model of vascularized lymph node transfer with predictable afferent lymphatic reconnection. Both the vascularization and reconnection might be necessary for functional regeneration of the transferred lymph node.

    DOI： 10.1002/micr.30394

    PubMed

    researchmap

  • NEDD4 Is Involved in Inflammation Development during Keloid Formation. Reviewed International journal

    Munezumi Fujita, Yuhei Yamamoto, Jing-Jing Jiang, Toru Atsumi, Yuki Tanaka, Takuto Ohki, Naoki Murao, Emi Funayama, Toshihiko Hayashi, Masayuki Osawa, Taku Maeda, Daisuke Kamimura, Masaaki Murakami

    The Journal of investigative dermatology   139 ( 2 )   333 - 341   2019.2

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Keloids mark a chronic inflammatory disease characterized by a fibroproliferative disorder of the skin. A genome-wide association study showed that single-nucleotide polymorphism rs8032158 in the neural precursor cell-expressed NEDD4 gene, which has six protein-coding transcript variants (TVs), is genetically linked to keloids. Here, we show that the high frequency of risk allele C in rs8032158 in keloid patients is associated with a selectively higher expression of TV3 of NEDD4 to activate the NF-κB pathway. Comparisons of keloid scars with normal skin samples that do not have the single-nucleotide polymorphism allele and were derived from different anatomical sites showed stronger expressions of NEDD4 TV3 and activated forms of NF-κB and STAT3 in keloid scars. Forced expression or selective knockdown of NEDD4 TV3 increased or decreased NF-κB activation in vitro. Furthermore, NEDD4 knockdown suppressed NF-κB-dependent inflammation development in vivo. Mechanistic analysis showed that NEDD4 TV3 is involved in NF-κB activation through its association with the adaptor protein RIP. These results suggest that NEDD4 TV3 is a potential diagnostic marker and therapeutic target for chronic skin diseases, including keloid.

    DOI： 10.1016/j.jid.2018.07.044

    PubMed

    researchmap

  • Comparison of Nasal Symmetry Between Presurgical Nasal Stenting and Postsurgical Nasal Retainer Placement in Unilateral Clefts. Reviewed International journal

    Emi Funayama, Yuhei Yamamoto, Akihiko Oyama, Hiroshi Furukawa, Naoki Murao, Toshihiko Hayashi, Taku Maeda, Masayuki Osawa

    The Journal of craniofacial surgery   30 ( 1 )   133 - 136   2019.1

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    The timing of cleft lip nose surgery remains controversial. The less invasive the procedure at the time of primary cleft lip repair, the less the growth and development of the nose is affected. Therefore, the nasal-stenting component of presurgical nasoalveolar molding has increasingly been used. However, not all cleft centers use such treatment. Conventional postsurgical placement of silicone nasal retainers remains popular. No report has yet compared presurgical nasal stenting (preNS) and postsurgical nasal retainer placement (postNR). In this study, postoperative nasal form outcomes after primary lip repair using preNS or postNR in patients with complete unilateral cleft lips, alveoli, and palates were compared. Patients in whom preNS alone was used for 6 months (group I) were compared with those receiving postNR (no preNS) for 6 months after primary nasal cartilage dissection (group II) and controls with no appliance (group III). Nasal anthropometric distances and angular relationships were measured photographically to assess nasal symmetry at 4 years of age in all groups. Compared to group III, groups I and II exhibited significantly greater nostril heights (P = 0.0075, P = 0.0015 respectively) and columellar deviation angles (P = 0.0020, P = 0.0221). Groups I and II did not differ significantly. No significant between-treatment difference in terms of nasal symmetry between preNS and postNR was observed. However, both treatments afforded significantly better results than no treatment. Since older infants tend to resist the placement of nasal devices, preNS is more feasible in this age group.

    DOI： 10.1097/SCS.0000000000004959

    PubMed

    researchmap

  • Diagnosis and Treatment of Keloids and Hypertrophic Scars-Japan Scar Workshop Consensus Document 2018. International journal

    Rei Ogawa, Sadanori Akita, Satoshi Akaishi, Noriko Aramaki-Hattori, Teruyuki Dohi, Toshihiko Hayashi, Kazuo Kishi, Taro Kono, Hajime Matsumura, Gan Muneuchi, Naoki Murao, Munetomo Nagao, Keisuke Okabe, Fumiaki Shimizu, Mamiko Tosa, Yasuyoshi Tosa, Satoko Yamawaki, Shinichi Ansai, Norihisa Inazu, Toshiko Kamo, Reiko Kazki, Shigehiko Kuribayashi

    Burns & trauma   7   39 - 39   2019

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    There has been a long-standing need for guidelines on the diagnosis and treatment of keloids and hypertrophic scars that are based on an understanding of the pathomechanisms that underlie these skin fibrotic diseases. This is particularly true for clinicians who deal with Asian and African patients because these ethnicities are highly prone to these diseases. By contrast, Caucasians are less likely to develop keloids and hypertrophic scars, and if they do, the scars tend not to be severe. This ethnic disparity also means that countries vary in terms of their differential diagnostic algorithms. The lack of clear treatment guidelines also means that primary care physicians are currently applying a hotchpotch of treatments, with uneven outcomes. To overcome these issues, the Japan Scar Workshop (JSW) has created a tool that allows clinicians to objectively diagnose and distinguish between keloids, hypertrophic scars, and mature scars. This tool is called the JSW Scar Scale (JSS) and it involves scoring the risk factors of the individual patients and the affected areas. The tool is simple and easy to use. As a result, even physicians who are not accustomed to keloids and hypertrophic scars can easily diagnose them and judge their severity. The JSW has also established a committee that, in cooperation with outside experts in various fields, has prepared a Consensus Document on keloid and hypertrophic scar treatment guidelines. These guidelines are simple and will allow even inexperienced clinicians to choose the most appropriate treatment strategy. The Consensus Document is provided in this article. It describes (1) the diagnostic algorithm for pathological scars and how to differentiate them from clinically similar benign and malignant tumors, (2) the general treatment algorithms for keloids and hypertrophic scars at different medical facilities, (3) the rationale behind each treatment for keloids and hypertrophic scars, and (4) the body site-specific treatment protocols for these scars. We believe that this Consensus Document will be helpful for physicians from all over the world who treat keloids and hypertrophic scars.

    DOI： 10.1186/s41038-019-0175-y

    PubMed

    researchmap

  • 顔面神経麻痺に対するマイクロサージャーリー 顔面神経不全麻痺に対する、舌下神経の流入型端側神経縫合を用いたネットワーク型神経再建

    古川 洋志, 七戸 龍司, 前田 拓, 林 利彦, 山本 有平

    日本マイクロサージャリー学会学術集会プログラム・抄録集   45回   140 - 140   2018.12

    　More details

    Language：Japanese   Publisher：(一社)日本マイクロサージャリー学会  

    researchmap

  • Immune-mediated antitumor effect of a transplanted lymph node. Reviewed International journal

    Taku Maeda, Toshihiko Hayashi, Hiroshi Furukawa, Daisuke Iwasaki, Kosuke Ishikawa, Emi Funayama, Naoki Murao, Masayuki Osawa, Akihiko Oyama, Yuhei Yamamoto

    International journal of cancer   143 ( 5 )   1224 - 1235   2018.9

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Lymph node (LN) transplantation is a recognized method for reconstruction of the lymphatic system and is used in the clinical setting to treat lymphedema. However, it is unclear whether transplanted LNs contribute to immune surveillance. In our study, we investigated whether a single transplanted non-vascularized LN, defined as a tumor-draining transplanted lymph node (TDTLN), could exert an immune-mediated antitumor effect. LN and lung metastases and primary tumor enlargement were evaluated in mice that were inoculated with B16-F10-luc2 melanoma cells in a hind limb footpad without (group 1) and with (group 2) popliteal lymph node (PLN) resection and in mice that underwent LN transplantation after PLN resection (group 3). The function of a TDTLN (group 3) and a tumor-draining popliteal lymph node (TDPLN; group 1) was evaluated in the context of cancer. LN and lung metastases were significantly aggravated by PLN resection but were significantly decreased by LN transplantation. Immunohistochemistry showed that the TDTLNs retained T-cells and B-cells and fluorescence-activated cell sorting analysis confirmed expansion of lymphocytes in these nodes; however, the degree of expansion in TDTLNs was different from that in TDPLNs. Expression of cytokines associated with immunostimulation was confirmed in the TDTLNs as well as in the TDPLNs. One of the differences in the immune-mediated antitumor effect of the TDPLNs and TDTLNs was ascribed to a difference in the site of lymphocyte homing to peripheral LNs through high endothelial venules. Non-vascularized LN transplantation had an immune-mediated antitumor effect.

    DOI： 10.1002/ijc.31414

    PubMed

    researchmap

  • 下肢熱圧挫損傷後の骨、軟部組織におけるMRI信号の経時的変化

    草島 英梨香, 村尾 尚規, 前田 拓, 林 利彦, 七戸 龍司, 山本 有平

    日本下肢救済・足病学会誌   10 ( 2 )   169 - 169   2018.7

    　More details

    Language：Japanese   Publisher：日本下肢救済・足病学会  

    researchmap

  • チームサージャリーにおける形成外科の貢献に関する10年間の検討

    石川 耕資, 古川 洋志, 小山 明彦, 舟山 恵美, 林 利彦, 村尾 尚規, 大澤 昌之, 前田 拓, 関堂 充, 山本 有平

    日本形成外科学会会誌   38 ( 6 )   277 - 282   2018.6

    　More details

    Language：Japanese   Publisher：(一社)日本形成外科学会  

    researchmap

  • [A 10-year analysis of the contribution of plastic surgeons to team surgery] Reviewed

    Kosuke Ishikawa, Hiroshi Furukawa, Akihiko Oyama, Emi Funayama, Toshihiko Hayashi, Naoki Murao, Masayuki Osawa, Taku Maeda, Mitsuru Sekido, Yuhei Yamamoto

    Journal of Japan Society of Plastic and Reconstructive Surgery   38 ( 6 )   277 - 282   2018.6

    　More details

    Language：Japanese   Publisher：(一社)日本形成外科学会  

    researchmap

  • Lymphatic Reconnection and Restoration of Lymphatic Flow by Nonvascularized Lymph Node Transplantation: Real-Time Fluorescence Imaging Using Indocyanine Green and Fluorescein Isothiocyanate-Dextran. Reviewed International journal

    Taku Maeda, Yuhei Yamamoto, Daisuke Iwasaki, Toshihiko Hayashi, Emi Funayama, Akihiko Oyama, Naoki Murao, Hiroshi Furukawa

    Lymphatic research and biology   16 ( 2 )   165 - 173   2018.4

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Mary Ann Liebert Inc.  

    DOI： 10.1089/lrb.2016.0070

    Scopus

    PubMed

    researchmap

  • Apert症候群との鑑別を要したoral-facial-digital syndrome type Iの1例

    伊藤 梨里, 小山 明彦, 林 利彦, 舟山 恵美, 古川 洋志, 山本 有平

    日本頭蓋顎顔面外科学会誌   33 ( 4 )   132 - 136   2017.12

    　More details

    Language：Japanese   Publisher：(一社)日本頭蓋顎顔面外科学会  

    researchmap

  • Long-Term Changes in Bone Height After Mandibular Reconstruction Using a Free Fibula Graft in an Elderly Population Reviewed

    Kosuke Ishikawa, Yuhei Yamamoto, Hiroshi Furukawa, Yoichi Ohiro, Akira Satoh, Toshihiko Hayashi

    JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY   75 ( 12 )   2682 - 2688   2017.12

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.joms.2017.05.011

    Web of Science

    PubMed

    researchmap

  • 骨露出にいたった下肢熱圧挫損傷の治療経験

    草島 英梨香, 林 利彦, 七戸 龍司, 村尾 尚規, 石川 耕資, 古川 洋志, 山本 有平

    熱傷   43 ( 4 )   227 - 227   2017.11

    　More details

    Language：Japanese   Publisher：(一社)日本熱傷学会  

    researchmap

  • 睫毛へのビマトプロストの試用経験

    南本 俊之, 本田 進, 大野 健太郎, 草島 英梨香, 石川 耕資, 林 利彦

    函館医学誌   41 ( 1 )   63 - 66   2017.10

    　More details

  • 当院の医療関連機器圧迫創傷に関して その傾向と対策

    南本 俊之, 本田 進, 水木 猛夫, 古川 尚恵, 寺島 一豪, 大野 健太郎, 石川 耕資, 林 利彦

    Skin Surgery   26 ( 3 )   139 - 140   2017.10

    　More details

    Language：Japanese   Publisher：日本臨床皮膚外科学会  

    researchmap

  • Factors that Affected Functional Outcome After a Delayed Excision and Split-Thickness Skin Graft on the Dorsal Side of Burned Hands Reviewed

    Ryuji Shichinohe, Yuhei Yamamoto, Kunihiro Kawashima, Chu Kimura, Kentaro Ono, Katsumi Horiuchi, Tetsunori Yoshida, Naoki Murao, Toshihiko Hayashi, Emi Funayama, Akihiko Oyama, Hiroshi Furukawa

    JOURNAL OF BURN CARE & RESEARCH   38 ( 5 )   E851 - E858   2017.9

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1097/BCR.0000000000000505

    Web of Science

    PubMed

    researchmap

  • Dominant lymph drainage patterns in the occipital and parietal regions: evaluation of lymph nodes in patients with skin cancer of the head. Reviewed

    Taku Maeda, Yuhei Yamamoto, Hiroshi Furukawa, Akihiko Oyama, Emi Funayama, Naoki Murao, Toshihiko Hayashi

    International journal of clinical oncology   22 ( 4 )   774 - 779   2017.8

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s10147-017-1121-2

    Web of Science

    PubMed

    researchmap

  • Review and proposal of regional surgical management for melanoma: revisiting of integumentectomy and incontinuity dissection in treatment of skin melanoma. Reviewed

    Toshihiko Hayashi, Hiroshi Furukawa, Takashi Kitamura, Ryuji Shichinohe, Naoki Murao, Akihiko Oyama, Emi Funayama, Taku Maeda, Yuhei Yamamoto

    International journal of clinical oncology   22 ( 3 )   569 - 576   2017.6

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s10147-016-1085-7

    Web of Science

    PubMed

    researchmap

  • Hinged mastoid fascial flapを用いたトリーチャーコリンズ症候群のlow hairline microtiaの再建

    前田 拓, 小山 明彦, 舟山 恵美, 古川 洋志, 林 利彦, 村尾 尚規, 山本 有平

    日本形成外科学会会誌   37 ( 6 )   344 - 344   2017.6

    　More details

    Language：Japanese   Publisher：(一社)日本形成外科学会  

    researchmap

  • 下顎再建後のプレート露出に対するVAC治療システムおよび高気圧酸素療法を用いた集学的治療

    前田 拓, 林 利彦, 古川 洋志, 村尾 尚規, 小山 明彦, 舟山 恵美, 山本 有平

    日本形成外科学会会誌   37 ( 6 )   332 - 332   2017.6

    　More details

    Language：Japanese   Publisher：(一社)日本形成外科学会  

    researchmap

  • Full-Thickness Entire Nasal Alar Reconstruction Using a Forehead Flap in Asians: No Cartilaginous Infrastructural Lining Is Necessary Reviewed

    Emi Funayama, Yuhei Yamamoto, Hiroshi Furukawa, Naoki Murao, Ryuji Shichinohe, Takeshi Yamao, Toshihiko Hayashi, Akihiko Oyama

    JOURNAL OF CRANIOFACIAL SURGERY   28 ( 3 )   734 - 737   2017.5

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1097/SCS.0000000000003389

    Web of Science

    PubMed

    researchmap

  • 体幹悪性黒色腫の所属リンパ節と予後の検討

    村尾 尚規, 林 利彦, 古川 洋志, 七戸 龍司, 山本 有平

    日本皮膚悪性腫瘍学会学術大会プログラム・抄録集   33回   144 - 144   2017.5

    　More details

    Language：Japanese   Publisher：(一社)日本皮膚悪性腫瘍学会  

    researchmap

  • 耳下腺・頸部転移を認めた眼瞼脂腺癌の治療経験

    草島 英梨香, 林 利彦, 七戸 龍司, 古川 洋志, 池田 正起, 山本 有平

    日本皮膚悪性腫瘍学会学術大会プログラム・抄録集   33回   192 - 192   2017.5

    　More details

    Language：Japanese   Publisher：(一社)日本皮膚悪性腫瘍学会  

    researchmap

  • 鼠径部に生じた脱分化型脂肪肉腫の1例

    七戸 龍司, 古川 洋志, 村尾 尚規, 林 利彦, 山本 有平, 今本 鉄平, 岡田 宏美, 三橋 智子

    日本皮膚悪性腫瘍学会学術大会プログラム・抄録集   33回   166 - 166   2017.5

    　More details

    Language：Japanese   Publisher：(一社)日本皮膚悪性腫瘍学会  

    researchmap

  • Application of vacuum-assisted closure therapy and hyperbaric oxygen therapy for an exposed titanium plate after mandible reconstruction: a case report

    Toshihiko Hayashi, Yuichi Ashikaga, Y. Ohiro, Kanchu Tei, S. Tanaka, Taku Maeda, R. Yoshitatsu, Kazuyo Kuribayashi

    International Journal of Oral and Maxillofacial Surgery   46   336   2017.3

    　More details

  • 口腔がん再建術後に中心静脈カテーテル関連深部静脈血栓症を生じた2例 DVTに対する歯科医師の対応について

    秦 浩信, 佐藤 明, 宮腰 昌明, 吉川 和人, 清水 六花, 林 利彦, 箕輪 和行, 北川 善政

    日本口腔腫瘍学会誌   29 ( 1 )   1 - 8   2017.3

    　More details

    Language：Japanese   Publisher：(一社)日本口腔腫瘍学会  

    DOI： 10.5843/jsot.29.1

    researchmap

  • 手指高度挫滅創の1経験

    南本 俊之, 大野 健太郎, 天王地 敏雅, 中島 菊雄, 草島 英梨香, 石川 耕資, 林 利彦

    函館医学誌   40 ( 1 )   22 - 25   2016.11

    　More details

  • 下顎再建後の嚥下機能における義歯の役割

    林 利彦, 古川 洋志, 濱田 浩美, 七戸 龍司, 山本 有平

    日本マイクロサージャリー学会学術集会プログラム・抄録集   43回   265 - 265   2016.11

    　More details

    Language：Japanese   Publisher：(一社)日本マイクロサージャリー学会  

    researchmap

  • 頭頸部再建を極める 下顎再建における再建法の選択の考え方 皮弁の種類/自家骨あるいはプレート再建/double flapsの選択

    林 利彦, 古川 洋志, 七戸 龍司, 山本 有平

    日本マイクロサージャリー学会学術集会プログラム・抄録集   43回   110 - 110   2016.11

    　More details

    Language：Japanese   Publisher：(一社)日本マイクロサージャリー学会  

    researchmap

  • Application of Vacuum-Assisted Closure Therapy and Hyperbaric Oxygen Therapy for an Exposed Titanium Plate After Mandible Reconstruction. Reviewed International journal

    Taku Maeda, Yuhei Yamamoto, Soichi Tanaka, Toshihiko Hayashi

    The Journal of craniofacial surgery   27 ( 7 )   e601-e604 - E604   2016.10

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1097/SCS.0000000000002917

    Web of Science

    PubMed

    researchmap

  • 当院での壊死性筋膜炎症例の検討

    南本 俊之, 大野 健太郎, 笠島 浩行, 辻口 直紀, 武山 佳洋, 草島 英梨香, 石川 耕資, 林 利彦

    Skin Surgery   25 ( 3 )   156 - 158   2016.10

    　More details

  • 3つのコンセプトを融合した片側唇裂口唇形成術の改良法 "ASSIST" technique

    小山 明彦, 舟山 恵美, 古川 洋志, 林 利彦, 村尾 尚規, 七戸 龍司, 山本 有平

    日本頭蓋顎顔面外科学会誌   32 ( 3 )   182 - 182   2016.10

    　More details

    Language：Japanese   Publisher：(一社)日本頭蓋顎顔面外科学会  

    researchmap

  • 広範な先天性頭皮頭蓋骨欠損の治療経験 保存的治療か外科的治療か

    前田 拓, 小山 明彦, 舟山 恵美, 古川 洋志, 林 利彦, 村尾 尚規, 七戸 龍司, 山本 有平

    日本頭蓋顎顔面外科学会誌   32 ( 3 )   216 - 216   2016.10

    　More details

    Language：Japanese   Publisher：(一社)日本頭蓋顎顔面外科学会  

    researchmap

  • 初回口蓋形成術後の言語成績の比較検討 非症候群性Pierre Robin Sequence VS非症候群性口蓋裂

    前田 拓, 舟山 恵美, 小山 明彦, 古川 洋志, 林 利彦, 村尾 尚規, 七戸 龍司, 山本 有平

    日本頭蓋顎顔面外科学会誌   32 ( 3 )   183 - 183   2016.10

    　More details

    Language：Japanese   Publisher：(一社)日本頭蓋顎顔面外科学会  

    researchmap

  • Reconstruction of Large Cheek Defect With/Without Sideburn Using Malar-Posterior Auricular-Cervico Flap Reviewed

    Toshihiko Hayashi, Yuhei Yamamoto, Akihiko Oyama, Emi Funayama, Ryuji Shichinohe, Naoki Murao, Hiroshi Furukawa

    ANNALS OF PLASTIC SURGERY   77 ( 2 )   173 - 177   2016.8

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1097/SAP.0000000000000575

    Web of Science

    PubMed

    researchmap

  • 後頭リンパ節に転移を認めた頭部原発皮膚悪性腫瘍におけるリンパ流の検討

    林 利彦, 古川 洋志, 村尾 尚規, 七戸 龍司, 山本 有平

    日本皮膚悪性腫瘍学会学術大会プログラム・抄録集   32回   140 - 140   2016.5

    　More details

    Language：Japanese   Publisher：(一社)日本皮膚悪性腫瘍学会  

    researchmap

  • 眼球浸潤および耳下腺内リンパ節転移を認めた左眼瞼脂腺癌の1例

    七戸 龍司, 古川 洋志, 村尾 尚規, 林 利彦, 山本 有平, 石嶋 漢, 桑原 健, 畑中 佳奈子

    日本皮膚悪性腫瘍学会学術大会プログラム・抄録集   32回   133 - 133   2016.5

    　More details

    Language：Japanese   Publisher：(一社)日本皮膚悪性腫瘍学会  

    researchmap

  • Prevention of Lymphedematous Change in the Mouse Hindlimb by Nonvascularized Lymph Node Transplantation Reviewed

    Ryuta Shioya, Hiroshi Furukawa, Naoki Murao, Toshihiko Hayashi, Akihiko Oyama, Emi Funayama, Yuhei Yamamoto, Noriko Saito

    ANNALS OF PLASTIC SURGERY   76 ( 4 )   442 - 445   2016.4

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1097/SAP.0000000000000428

    Web of Science

    PubMed

    researchmap

  • 初回口蓋形成術後の鼻咽腔閉鎖不全と二次修正術について 非症候性Pierre Robin Sequenceと非症候性口蓋裂

    前田 拓, 舟山 恵美, 小山 明彦, 古川 洋志, 林 利彦, 村尾 尚規, 七戸 龍司, 山本 有平

    日本口蓋裂学会雑誌   41 ( 2 )   104 - 104   2016.4

    　More details

    Language：Japanese   Publisher：(一社)日本口蓋裂学会  

    researchmap

  • Neuregulin-1 released by biodegradable gelatin hydrogels can accelerate facial nerve regeneration and functional recovery of traumatic facial nerve palsy Reviewed

    Go Yasui, Yuhei Yamamoto, Ryuji Shichinohe, Emi Funayama, Akihiko Oyama, Toshihiko Hayashi, Hiroshi Furukawa

    JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY   69 ( 3 )   328 - 334   2016.3

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.bjps.2015.10.037

    Web of Science

    researchmap

  • 小耳症耳介形成術後の皮膚潰瘍の予防を目的とした高気圧酸素療法の有用性

    小山 明彦, 塩谷 隆太, 古川 洋志, 舟山 恵美, 林 利彦, 村尾 尚規, 七戸 龍司, 山本 有平

    日本形成外科学会会誌   36 ( 3 )   138 - 138   2016.3

    　More details

    Language：Japanese   Publisher：(一社)日本形成外科学会  

    researchmap

  • 北大形成外科における下肢リンパ浮腫の治療戦略

    古川 洋志, 七戸 龍司, 林 利彦, 大野 健太郎, 塩谷 隆太, 山本 有平

    日本形成外科学会会誌   36 ( 3 )   138 - 138   2016.3

    　More details

    Language：Japanese   Publisher：(一社)日本形成外科学会  

    researchmap

  • 小耳症耳介形成術後の皮膚潰瘍に対する治療戦略

    小山 明彦, 古川 洋志, 舟山 恵美, 林 利彦, 村尾 尚規, 七戸 龍司, 山本 有平

    日本形成外科学会会誌   36 ( 3 )   137 - 137   2016.3

    　More details

    Language：Japanese   Publisher：(一社)日本形成外科学会  

    researchmap

  • A new primary cleft lip repair technique tailored for Asian patients that combines three surgical concepts: Comparison with rotation-advancement and straight-line methods Reviewed

    Emi Funayama, Yuhei Yamamoto, Hiroshi Furukawa, Naoki Murao, Ryuji Shichinohe, Toshihiko Hayashi, Akihiko Oyama

    JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY   44 ( 1 )   27 - 33   2016.1

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.jcms.2015.09.005

    Web of Science

    PubMed

    researchmap

  • 美容外科教育 大学での美容外科教育の現状と課題 北海道大学病院における整容・美容外科の現状と教育の課題

    舟山 恵美, 小山 明彦, 古川 洋志, 村尾 尚規, 七戸 龍司, 林 利彦, 山本 有平

    日本美容外科学会会報   37 ( 4 )   137 - 137   2015.12

    　More details

    Language：Japanese   Publisher：(一社)日本美容外科学会  

    researchmap

  • 端側神経縫合を用いた顔面神経麻痺に対するネットワーク型再建の手術手技

    古川 洋志, 七戸 龍司, 蕨 雄大, 安居 剛, 大野 健太郎, 林 利彦, 山本 有平

    日本形成外科学会会誌   35 ( 12 )   705 - 705   2015.12

    　More details

    Language：Japanese   Publisher：(一社)日本形成外科学会  

    researchmap

  • Early and long-term morbidity after minimally invasive total laryngo-pharyngo-esophagectomy with gastric pull-up reconstruction via thoracoscopy, laparoscopy and cervical incision. Reviewed

    Homma A, Nakamaru Y, Hatakeyama H, Mizumachi T, Kano S, Furusawa J, Sakashita T, Shichinohe T, Ebihara Y, Hirano S, Furukawa H, Hayashi T, Yamamoto Y, Fukuda S

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery   272 ( 11 )   3551 - 3556   2015.11

    　More details

  • 北海道大学病院における急性期熱傷症例の過去5年間の検討

    藤田 宗純, 村尾 尚規, 山尾 健, 七戸 龍司, 林 利彦, 舟山 恵美, 小山 明彦, 古川 洋志, 山本 有平, 丸藤 哲

    熱傷   41 ( 4 )   202 - 202   2015.11

    　More details

    Language：Japanese   Publisher：(一社)日本熱傷学会  

    researchmap

  • The improvement on swallowing function by wearing denture in the patients received mandibular reconstruction

    Toshihiko Hayashi, Y. Yamzaki, Yuichi Ashikaga, Kazuyo Kuribayashi, H. Hamada, Mitsunobu Ono, Kanchu Tei, Y. Ohiro

    International Journal of Oral and Maxillofacial Surgery   44   e272   2015.10

    　More details

  • 形成外科で経験した結核症例の検討

    南本 俊之, 足立 真紀, 高橋 隆二, 山添 雅己, 古屋 文康, 石川 耕資, 林 利彦

    Skin Surgery   24 ( 3 )   169 - 170   2015.10

    　More details

    Language：Japanese   Publisher：日本臨床皮膚外科学会  

    researchmap

  • Tessier No.3およびNo.4の合併症例 12年間のフォローアップ

    前田 拓, 小山 明彦, 岡本 亨, 舟山 恵美, 古川 洋志, 林 利彦, 村尾 尚規, 七戸 龍司, 山本 有平

    日本頭蓋顎顔面外科学会誌   31 ( 3 )   247 - 247   2015.10

    　More details

    Language：Japanese   Publisher：(一社)日本頭蓋顎顔面外科学会  

    researchmap

  • メラノーマ治療の画期的進歩と今後の課題 メラノーマの外科治療におけるICG蛍光リンパ管造影の現状と展望

    古川 洋志, 林 利彦, 七戸 龍司, 村尾 尚規, 山本 有平

    日本癌治療学会誌   50 ( 3 )   1071 - 1071   2015.9

    　More details

    Language：Japanese   Publisher：(一社)日本癌治療学会  

    researchmap

  • 皮膚腫瘍外科に役立つ画像診断 ICG蛍光リンパ管造影の利用

    林 利彦, 古川 洋志, 村尾 尚規, 七戸 龍司, 山本 有平

    日本皮膚悪性腫瘍学会学術大会プログラム・抄録集   31回   157 - 157   2015.7

    　More details

    Language：Japanese   Publisher：(一社)日本皮膚悪性腫瘍学会  

    researchmap

  • Pigmented epithelioid melanocytomaの1例

    七戸 龍司, 林 利彦, 本田 進, 村尾 尚規, 古川 洋志, 山本 有平, 三橋 智子, 中 智昭, 菊池 慶介

    日本皮膚悪性腫瘍学会学術大会プログラム・抄録集   31回   138 - 138   2015.7

    　More details

    Language：Japanese   Publisher：(一社)日本皮膚悪性腫瘍学会  

    researchmap

  • 右前腕部Spitz母斑様悪性黒色腫の1例

    七戸 龍司, 林 利彦, 村尾 尚規, 古川 洋志, 山本 有平, 菅野 宏美, 畑中 佳奈子, 福本 隆也, 木村 鉄宣

    日本皮膚悪性腫瘍学会学術大会プログラム・抄録集   31回   137 - 137   2015.7

    　More details

    Language：Japanese   Publisher：(一社)日本皮膚悪性腫瘍学会  

    researchmap

  • 上眼瞼全層欠損に対する余剰皮膚を利用した一期的再建

    林 利彦, 古川 洋志, 村尾 尚規, 七戸 龍司, 山本 有平

    日本皮膚悪性腫瘍学会学術大会プログラム・抄録集   31回   156 - 156   2015.7

    　More details

    Language：Japanese   Publisher：(一社)日本皮膚悪性腫瘍学会  

    researchmap

  • 北海道大学病院における広範囲熱傷の治療戦略 形成外科医の立場から

    藤田 宗純, 村尾 尚規, 七戸 龍司, 林 利彦, 舟山 恵美, 小山 明彦, 古川 洋志, 山本 有平, 宮本 大輔, 丸藤 哲

    熱傷   41 ( 2 )   99 - 99   2015.6

    　More details

    Language：Japanese   Publisher：(一社)日本熱傷学会  

    researchmap

  • 【All about 頭頸部再建-多彩な皮弁を使いこなす!】頭頸部再建に用いられる皮弁 遊離肩甲骨皮弁 頭頸部再建における応用

    七戸 龍司, 古川 洋志, 林 利彦, 山本 有平

    耳鼻咽喉科・頭頸部外科   87 ( 7 )   502 - 507   2015.6

    　More details

  • 上眼瞼全層欠損に対する余剰皮膚を利用したadvancement flapによる再建

    林 利彦, 古川 洋志, 七戸 龍司, 村尾 尚規, 小山 明彦, 舟山 恵美, 山本 有平

    頭頸部癌   41 ( 2 )   215 - 215   2015.5

    　More details

    Language：Japanese   Publisher：(一社)日本頭頸部癌学会  

    researchmap

  • 片側性唇顎口蓋裂の術前顎矯正および一期手術 術前・術後の歯槽形態の変化について

    岡本 亨, 小山 明彦, 舟山 恵美, 古川 洋志, 林 利彦, 村尾 尚規, 七戸 龍司, 山本 有平

    日本口蓋裂学会雑誌   40 ( 2 )   111 - 111   2015.4

    　More details

    Language：Japanese   Publisher：(一社)日本口蓋裂学会  

    researchmap

  • Dynamic change of myogenin in denervated rat mimetic muscle. Reviewed

    Warabi T, Furukawa H, Shichinohe R, Hayashi T, Yamamoto Y

    Facial plastic surgery : FPS   31 ( 2 )   152 - 159   2015.4

    　More details

  • Multiple primary melanomas detected after long-term follow-up for the first primary melanoma : A case report

    ONO Kentaro, FURUKAWA Hiroshi, HAYASHI Toshihiko, YAMAMOTO Yuhei

    Skin Cancer   30 ( 3 )   223 - 227   2015

    　More details

    Language：Japanese   Publisher：The Japanese Skin Cancer Society  

    We report a case of multiple primary melanomas detected after long-term follow-up for the first primary melanoma. A patient with cutaneous melanoma in the left breast region received treatment at 42 years of age. After the initial treatment, we followed the patient on a yearly basis. A new primary cutaneous melanoma was observed in the right femoral region at age 66 years. Wide local excision and sentinel lymph node biopsy were performed, which did not reveal any metastasis. Five years after the second treatment, a recurrent lesion was detected at the right inguinal lymph node. Extensive resection and lymph node dissection was performed, and the patient did not show any recurrence at the follow-up. In most cases of multiple primary melanomas, the second primary melanoma has been detected within a decade. We experienced a rare case of multiple primary melanomas occurring 24 years after the first primary tumor was detected.[Skin Cancer (Japan) 2015 ; 30 : 223-227]

    DOI： 10.5227/skincancer.30.223

    researchmap

    Other Link： http://search.jamas.or.jp/link/ui/2016374189

  • Combined therapy of NPWT and bipedicled flap as an alternative approach for giant abdominal wall defect with significant visceral edema: report of a case. Reviewed

    Yasui G, Furukawa H, Warabi T, Hayashi T, Oyama A, Funayama E, Yamamoto Y

    Case reports in plastic surgery & hand surgery   2 ( 2 )   25 - 28   2015

    　More details

  • 下顎再建後のプレート露出に対するVAC治療システムおよび高気圧酸素療法を用いた集学的治療

    前田 拓, 林 利彦, 古川 洋志, 七戸 龍司, 栗林 和代, 小野 貢伸, 村尾 尚規, 小山 明彦, 舟山 恵美, 山本 有平

    日本マイクロサージャリー学会学術集会プログラム・抄録集   41回   166 - 166   2014.12

    　More details

    Language：Japanese   Publisher：(一社)日本マイクロサージャリー学会  

    researchmap

  • 腹腔鏡下で採取された遊離空腸の移植術 血管吻合のピットフォールと対策

    古川 洋志, 林 利彦, 七戸 龍司, 村尾 尚規, 大野 健太郎, 安居 剛, 山本 有平

    日本マイクロサージャリー学会学術集会プログラム・抄録集   41回   155 - 155   2014.12

    　More details

    Language：Japanese   Publisher：(一社)日本マイクロサージャリー学会  

    researchmap

  • Combination of Tessier clefts 3 and 4: case report of a rare anomaly with 12 years' follow-up. Reviewed International journal

    Taku Maeda, Akihiko Oyama, Toru Okamoto, Emi Funayama, Hiroshi Furukawa, Toshihiko Hayashi, Naoki Murao, Yoshiaki Sato, Yuhei Yamamoto

    Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery   42 ( 8 )   1985 - 9   2014.12

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.jcms.2014.09.003

    Web of Science

    PubMed

    researchmap

  • 上口唇2/3以上の全層欠損あるいは口角を含む欠損の再建 局所皮弁/遊離皮弁の選択について

    林 利彦, 古川 洋志, 七戸 龍司, 山本 有平

    日本マイクロサージャリー学会学術集会プログラム・抄録集   41回   163 - 163   2014.12

    　More details

    Language：Japanese   Publisher：(一社)日本マイクロサージャリー学会  

    researchmap

  • 当科における過去10年間の頭頸部再建の遊離組織移植術後血栓症例の検討

    七戸 龍司, 古川 洋志, 林 利彦, 山本 有平, 齊藤 亮, 関堂 充

    日本マイクロサージャリー学会学術集会プログラム・抄録集   41回   159 - 159   2014.12

    　More details

    Language：Japanese   Publisher：(一社)日本マイクロサージャリー学会  

    researchmap

  • Important points for primary cleft palate repair for speech derived from speech outcome after three different types of palatoplasty Reviewed

    Emi Funayama, Yuhei Yamamoto, Noriko Nishizawa, Tadashi Mikoya, Toru Okamoto, Satoko Imai, Naoki Murao, Hiroshi Furukawa, Toshihiko Hayashi, Akihiko Oyama

    INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY   78 ( 12 )   2127 - 2131   2014.12

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.ijporl.2014.09.021

    Web of Science

    PubMed

    researchmap

  • ランゲルハンス細胞肉腫の1例

    南本 俊之, 杉井 政澄, 工藤 和洋, 下山 則彦, 大東 寛幸, 堤 豊, 足立 真紀, 石川 耕資, 林 利彦, 山本 有平

    Skin Surgery   23 ( 3 )   128 - 130   2014.10

    　More details

  • 当院における銃創の治療経験

    南本 俊之, 石川 耕資, 中島 菊雄, 佐藤 隆弘, 岩井 里子, 林 利彦

    Skin Surgery   23 ( 3 )   107 - 114   2014.10

    　More details

  • 【神経損傷に対する神経縫合・神経移植・神経剥離の実際と術後成績】端側神経縫合による顔面神経麻痺に対するネットワーク型再建 ビデオ映像による術式の紹介

    古川 洋志, 林 利彦, 七戸 龍司, 山本 有平

    日本マイクロサージャリー学会会誌   27 ( 3 )   67 - 71   2014.9

    　More details

  • Effectiveness of intraoperative indocyanine-green fluorescence angiography during inguinal lymph node dissection for skin cancer to prevent postoperative wound dehiscence. Reviewed

    Furukawa H, Hayashi T, Oyama A, Funayama E, Murao N, Yamao T, Yamamoto Y

    Surgery today   2014.7

    　More details

  • 腹腔鏡下遊離空腸採取に伴う問題点と対策

    村尾 尚規, 古川 洋志, 林 利彦, 山本 有平, 本間 明宏, 七戸 俊明

    頭頸部癌   40 ( 2 )   165 - 165   2014.5

    　More details

    Language：Japanese   Publisher：(一社)日本頭頸部癌学会  

    researchmap

  • Treg-enriched CD4+ T cells attenuate collagen synthesis in keloid fibroblasts. Reviewed

    Murao N, Seino K, Hayashi T, Ikeda M, Funayama E, Furukawa H, Yamamoto Y, Oyama A

    Experimental dermatology   23 ( 4 )   266 - 271   2014.4

    　More details

  • 顔面神経信号入力変化をRNAで捉える 顔面神経麻痺における顔面表情筋mRNA発現の定量(第3報)

    蕨 雄大, 林 利彦, 古川 洋志, 山本 有平, 七戸 龍司, 齋藤 亮

    日本形成外科学会会誌   34 ( 4 )   310 - 310   2014.4

    　More details

    Language：Japanese   Publisher：(一社)日本形成外科学会  

    researchmap

  • An Analysis of Cheek Reconstruction After Tumor Excision in Patients With Melanoma Reviewed

    Toshihiko Hayashi, Hiroshi Furukawa, Akihiko Oyama, Emi Funayama, Akira Saito, Yuhei Yamamoto

    JOURNAL OF CRANIOFACIAL SURGERY   25 ( 2 )   E98 - E101   2014.3

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1097/SCS.0000000000000397

    Web of Science

    PubMed

    researchmap

  • Dominant lymph drainage in the upper extremity and upper trunk region: evaluation of lymph drainage in patients with skin melanomas Reviewed

    Toshihiko Hayashi, Hiroshi Furukawa, Akihiko Oyama, Emi Funayama, Akira Saito, Yuhei Yamamoto

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   19 ( 1 )   193 - 197   2014.2

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s10147-012-0504-7

    Web of Science

    PubMed

    researchmap

  • Minor-Form/Microform Cleft Lip Repair The Importance of Identification and Utilization of Cupid Bow Peak on the Lateral Lip Reviewed

    Akihiko Oyama, Emi Funayama, Hiroshi Furukawa, Toshihiko Hayashi, Akira Saito, Yuhei Yamamoto

    ANNALS OF PLASTIC SURGERY   72 ( 1 )   47 - 49   2014.1

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1097/SAP.0b013e3182587215

    Web of Science

    PubMed

    researchmap

  • Skin necrosis around bilateral buttock of hikikomori teenager Reviewed

    Hiroshi Furukawa, Akihiko Oyama, Emi Funayama, Toshihiko Hayashi, Yuhei Yamamoto

    International Journal of Culture and Mental Health   7 ( 1 )   43 - 45   2014

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1080/17542863.2012.685485

    Scopus

    researchmap

  • Flap reconstruction in two patients with rare blood coagulation disorders Reviewed

    Toshihiko Hayashi, Akira Saito, Hiroshi Furukawa, Akihiko Oyama, Emi Funayama, Yuhei Yamamoto

    European Journal of Plastic Surgery   37 ( 5 )   297 - 300   2014

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Verlag  

    DOI： 10.1007/s00238-014-0933-9

    Scopus

    researchmap

  • Unfavorable Results of Head and Neck Reconstructive Cases Due to Complications of Microvascular Anastomosis Requiring Surgical Salvage

    FURUKAWA,Hiroshi, HAYASHI,Toshihiko, SAITO,Akira, YAMAMOTO,Yuhei, SEKIDO,Mitsuru

    J. Jpn. S. R. M.   27 ( 4 )   117 - 125   2014

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Japanese Society of Reconstructive Microsurgery  

    In this paper, a review of unfavorable head and neck reconstructive cases due to the complication of microvascular anastomosis at our institute is described. Between 2004 and 2014, the total number of head and neck reconstructive cases in which free flaps and microvascular augmentation were performed as team surgery was 239. In this series, 11 cases ( 4.4% ) required secondary surgical salvage due to postoperative thrombosis at the anastomosed site. Finally, 9 flaps failed and the rate of total necrosis of free flaps was 3.8%. Evaluation of the causes and methods of surgical salvage in cases with unfavorable results is very important for future advances and improvements in reconstructive surgery.

    researchmap

  • 神経損傷に対する神経縫合・神経移植・神経剥離の実際と術後成績 端側神経縫合による顔面神経麻痺に対するネットワーク型再建

    古川 洋志, 林 利彦, 蕨 雄大, 山本 有平, 七戸 龍司, 齋藤 亮

    日本マイクロサージャリー学会学術集会プログラム・抄録集   40周年記念   112 - 112   2013.9

    　More details

    Language：Japanese   Publisher：(一社)日本マイクロサージャリー学会  

    researchmap

  • 組織移植術における手技と主義 端側神経縫合を用いた顔面神経麻痺に対するネットワーク型再建

    古川 洋志, 蕨 雄大, 林 利彦, 山本 有平, 七戸 龍司, 齋藤 亮

    日本形成外科学会会誌   33 ( 5 )   366 - 366   2013.5

    　More details

    Language：Japanese   Publisher：(一社)日本形成外科学会  

    researchmap

  • 顔面神経信号入力変化をRNAでとらえる 顔面神経麻痺における顔面表情筋mRNA発現の定量(第2報)

    蕨 雄大, 林 利彦, 古川 洋志, 山本 有平, 七戸 龍司, 齋藤 亮

    日本形成外科学会会誌   33 ( 4 )   290 - 290   2013.4

    　More details

    Language：Japanese   Publisher：(一社)日本形成外科学会  

    researchmap

  • Efficacy of percutaneous ethanol sclerotherapy for venous malformation in lower extremities: A retrospective review of 21 cases Reviewed

    Hiroshi Furukawa, Satoru Sasaki, Akihiko Oyama, Emi Funayama, Toshihiko Hayashi, Noriko Saito, Munetomo Nagao, William Mol, Yuhei Yamamoto

    European Journal of Plastic Surgery   36 ( 2 )   105 - 110   2013.2

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s00238-012-0754-7

    Scopus

    researchmap

  • A New Aspect of Metastasis in Cutaneous Cancer Two Cases of Presacral Squamous Cell Carcinoma With Metastases to Internal Iliac Nodes Reviewed

    Kohei Oashi, Toshihiko Hayashi, Hiroshi Furukawa, Arata Tsutsumida, Chu Kimura, Hiroshi Oyamatsu, Akihiko Oyama, Emi Funayama, Akira Saito, Yuhei Yamamoto

    ANNALS OF PLASTIC SURGERY   70 ( 1 )   79 - 81   2013.1

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1097/SAP.0b013e31821daaac

    Web of Science

    PubMed

    researchmap

  • 皮膚がんに特化した鼠径リンパ節の郭清範囲とは

    大芦 孝平, 古川 洋志, 林 利彦, 山本 有平

    Skin Cancer   27 ( 3 )   271 - 272   2013

    　More details

    Language：Japanese   Publisher：The Japanese Skin Cancer Society  

    DOI： 10.5227/skincancer.27.271

    researchmap

    Other Link： http://search.jamas.or.jp/link/ui/2013207366

  • ICGを併用したnavigation surgery－SLNBおよび腫瘍切除/所属リンパ節郭清に対する新たな取り組み－

    林 利彦, 古川 洋志, 大芦 孝平, 小山 明彦, 舟山 恵美, 山本 有平

    Skin Cancer   27 ( 3 )   294 - 295   2013

    　More details

    Language：Japanese   Publisher：The Japanese Skin Cancer Society  

    DOI： 10.5227/skincancer.27.294

    researchmap

    Other Link： http://search.jamas.or.jp/link/ui/2013207382

  • 皮膚がん治療における頸部郭清術の工夫

    林 利彦, 古川 洋志, 大芦 孝平, 小山 明彦, 舟山 恵美, 山本 有平

    Skin Cancer   27 ( 3 )   268 - 268   2013

    　More details

    Language：Japanese   Publisher：The Japanese Skin Cancer Society  

    DOI： 10.5227/skincancer.27.268

    researchmap

    Other Link： http://search.jamas.or.jp/link/ui/2013207364

  • Pathophysiological characteristics of melanoma in-transit metastasis in a lymphedema mouse model Reviewed

    Kohei Oashi, Hiroshi Furukawa, Hiroshi Nishihara, Michitaka Ozaki, Akihiko Oyama, Emi Funayama, Toshihiko Hayashi, Yuji Kuge, Yuhei Yamamoto

    Journal of Investigative Dermatology   133 ( 2 )   537 - 544   2013

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Nature Publishing Group  

    DOI： 10.1038/jid.2012.274

    Scopus

    PubMed

    researchmap

  • 皮膚がんに特化した腋窩リンパ節郭清術についての検討

    古川 洋志, 林 利彦, 大芦 孝平, 小山 明彦, 舟山 恵美, 山本 有平, 堤田 新, 齋藤 亮, 皆川 英彦, 吉田 哲憲

    Skin Cancer   27 ( 3 )   274 - 274   2013

    　More details

    Language：Japanese   Publisher：The Japanese Skin Cancer Society  

    DOI： 10.5227/skincancer.27.274

    researchmap

    Other Link： http://search.jamas.or.jp/link/ui/2013207368

  • 神経縫合後の顔面表情筋mRNA発現変化についての基礎研究(第3報)

    蕨 雄大, 七戸 龍司, 齋藤 亮, 林 利彦, 古川 洋志, 山本 有平

    日本マイクロサージャリー学会学術集会プログラム・抄録集   39回   296 - 296   2012.12

    　More details

    Language：Japanese   Publisher：(一社)日本マイクロサージャリー学会  

    researchmap

  • Microsurgical lymphaticovenous implantation targeting dermal lymphatic backflow using indocyanine green fluorescence lymphography in the treatment of postmastectomy lymphedema

    古川, 洋志, 大澤, 昌之, 齋藤, 亮, 林, 利彦, 舟山, 恵美, 小山, 明彦, 関堂, 充, 山本, 有平

    北海道醫學雜誌 = Acta medica Hokkaidonensia   87 ( 6 )   270   2012.11

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)  

    researchmap

  • A New Model of Acquired Lymphedema in the Mouse Hind Limb A Preliminary Report Reviewed

    Kohei Oashi, Hiroshi Furukawa, Akihiko Oyama, Emi Funayama, Toshihiko Hayashi, Akira Saito, Yuhei Yamamoto

    ANNALS OF PLASTIC SURGERY   69 ( 5 )   565 - 568   2012.11

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1097/SAP.0b013e31821ee3dd

    Web of Science

    PubMed

    researchmap

  • 顔面神経再建方法の分類と呼称 ネットワーク型再建とその周辺の用語について

    古川 洋志, 七戸 龍司, 蕨 雄大, 齋藤 亮, 林 利彦, 山本 有平

    Facial Nerve Research   32   44 - 45   2012.11

    　More details

    Language：Japanese   Publisher：日本顔面神経学会  

    researchmap

  • Effectiveness of combined pulsed dye and Q-switched ruby laser treatment for large to giant congenital melanocytic naevi Reviewed

    E. Funayama, S. Sasaki, H. Furukawa, T. Hayashi, T. Yamao, K. Takahashi, Y. Yamamoto, A. Oyama

    BRITISH JOURNAL OF DERMATOLOGY   167 ( 5 )   1085 - 1091   2012.11

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/j.1365-2133.2012.11058.x

    Web of Science

    researchmap

  • 悪性グロームス腫瘍の1治療経験

    南本 俊之, 石川 耕資, 工藤 和洋, 下山 則彦, 岩井 里子, 林 利彦

    道南医学会大会並びに総会プログラム・抄録集   65回   60 - 60   2012.11

    　More details

    Language：Japanese   Publisher：道南医学会  

    researchmap

  • Vascularised fat flaps lose 44% of their weight 24 weeks after transplantation Reviewed

    Kohei Oashi, Hiroshi Furukawa, Sadanori Akita, Masahiro Nakashima, Katsuya Matsuda, Akihiko Oyama, Emi Funayama, Toshihiko Hayashi, Akiyoshi Hirano, Yuhei Yamamoto

    JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY   65 ( 10 )   1403 - 1409   2012.10

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.bjps.2012.04.036

    Web of Science

    PubMed

    researchmap

  • Dominant lymph drainage in the facial region: evaluation of lymph nodes of facial melanoma patients Reviewed

    Toshihiko Hayashi, Hiroshi Furukawa, Akihiko Oyama, Emi Funayama, Akira Saito, Yuhei Yamamoto

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   17 ( 4 )   330 - 335   2012.8

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s10147-011-0293-4

    Web of Science

    PubMed

    researchmap

  • A New Uniform Protocol of Combined Corticosteroid Injections and Ointment Application Reduces Recurrence Rates After Surgical Keloid/Hypertrophic Scar Excision Reviewed

    Toshihiko Hayashi, Hiroshi Furukawa, Akihiko Oyama, Emi Funayama, Akira Saito, Naoki Murao, Yuhei Yamamoto

    DERMATOLOGIC SURGERY   38 ( 6 )   893 - 897   2012.6

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/j.1524-4725.2012.02345.x

    Web of Science

    PubMed

    researchmap

  • Direction of innervation after interpositional nerve graft between facial and hypoglossal nerves in individuals with or without facial palsy: A rat model for treating incomplete facial palsy Reviewed

    Ryuji Shichinohe, Hiroshi Furukawa, Mitsuru Sekido, Akira Saito, Toshihiko Hayashi, Emi Funayama, Akihiko Oyama, Yuhei Yamamoto

    JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY   65 ( 6 )   763 - 770   2012.6

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.bjps.2011.12.009

    Web of Science

    PubMed

    researchmap

  • 当教室における顔面神経再建時の神経端側縫合術と,ラットを用いた表情筋の神経二重支配の検証

    古川洋志, 七戸龍司, 蕨雄大, 林利彦, 山本有平

    頭けい部癌   38 ( 2 )   198   2012.5

    　More details

    Language：Japanese  

    J-GLOBAL

    researchmap

  • Sentinel lymph node biopsy using real-time fluorescence navigation with indocyanine green in cutaneous head and neck/lip mucosa melanomas Reviewed

    Toshihiko Hayashi, Hiroshi Furukawa, Akihiko Oyama, Emi Funayama, Akira Saito, Takeshi Yamao, Yuhei Yamamoto

    HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK   34 ( 5 )   758 - 761   2012.5

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/hed.21651

    Web of Science

    PubMed

    researchmap

  • Reconstruction of periorbital defects following malignant tumour excision: A report of 50 cases Reviewed

    Akira Saito, Noriko Saito, Hiroshi Furukawa, Toshihiko Hayashi, Akihiko Oyama, Emi Funayama, Hidehiko Minakawa, Yuhei Yamamoto

    JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY   65 ( 5 )   665 - 670   2012.5

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.bjps.2011.09.012

    Web of Science

    PubMed

    researchmap

  • cervicomalar flapの皮切デザインによるSLNB/頸部郭清術と再建:Oncoplastic Skin Surgery腫瘍切除と再建

    林利彦, 古川洋志, 大芦孝平, 塩谷隆太, 池田正起, 村尾尚規, 山本有平

    頭頸部癌   38 ( 2 )   155   2012.5

    　More details

    Language：Japanese  

    J-GLOBAL

    researchmap

  • Tailored excision of in-transit metastatic melanoma based on indocyanine green fluorescence lymphography Reviewed

    Hiroshi Furukawa, Toshihiko Hayashi, Akihiko Oyama, Akira Takasawa, Yuhei Yamamoto

    European Journal of Plastic Surgery   35 ( 4 )   329 - 332   2012.4

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s00238-010-0526-1

    Scopus

    researchmap

  • Effectiveness of muscle coverage to manage osteomyelitis of very late onset in the irradiated chest wall Reviewed

    Emi Funayama, Hidehiko Minakawa, Hidekazu Otani, Akihiko Oyama, Hiroshi Furukawa, Toshihiko Hayashi, Noriko Saito, Akira Saito, Yuhei Yamamoto

    SURGERY TODAY   42 ( 3 )   306 - 311   2012.2

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s00595-011-0078-4

    Web of Science

    PubMed

    researchmap

  • A case of squamous cell carcinoma on a chronic venous ulcer of the leg

    YAMAO Takeshi, FURUKAWA Hiroshi, HAYASHI Toshihiko, KOURABA Sachio, HONDA Kouichi, YAMAMOTO Yuhei

    Skin Cancer   27 ( 1 )   64 - 66   2012

    　More details

    Publisher：The Japanese Skin Cancer Society  

    A 72-year-old male was suffering from a chronic ulcer on his left lower leg treated by a cardiovascular surgeon for 40 years. One year ago, the plastic surgeon performed a biopsy at the site of the tumor on the ulcer, and histological examination suspected it to be malignant. He consulted our hospital for treatment of the tumor. A 25×15 cm-sized mass was located on his left lower leg. Above-knee amputation was performed. A pathological diagnosis of squamous cell carcinoma, and stage III (T3N0M0) was established. No relapse or metastasis has been observed during a 10-month follow-up period. ...

    DOI： 10.5227/skincancer.27.64

    J-GLOBAL

    researchmap

  • 神経縫合後の顔面表情筋mRNA発現変化についての基礎研究(第2報)

    蕨 雄大, 七戸 龍司, 齋藤 亮, 林 利彦, 古川 洋志, 山本 有平

    日本マイクロサージャリー学会学術集会プログラム・抄録集   38回   224 - 224   2011.11

    　More details

    Language：Japanese   Publisher：(一社)日本マイクロサージャリー学会  

    researchmap

  • 顔面神経麻痺に対する神経移行術(端側縫合を含む) ネットワーク型再建による耳下腺癌切除後の顔面神経即時再建 頸神経ワナ翻転法、ALT皮弁内外側大腿皮神経移植の試み

    古川 洋志, 齋藤 亮, 林 利彦, 蕨 雄大, 山本 有平, 関堂 充, 七戸 龍司

    日本マイクロサージャリー学会学術集会プログラム・抄録集   38回   153 - 153   2011.11

    　More details

    Language：Japanese   Publisher：(一社)日本マイクロサージャリー学会  

    researchmap

  • INTRAOPERATIVE COLOR DOPPLER SONOGRAPHY IN THE ELEVATION OF ANTEROLATERAL THIGH FLAP Reviewed

    Akira Saito, Hiroshi Furukawa, Toshihiko Hayashi, Akihiko Oyama, Emi Funayama, Yuhei Yamamoto

    MICROSURGERY   31 ( 7 )   582 - 583   2011.10

    　More details

  • The Importance of the Anti-aging Rejuvenation Clinic at Hokkaido University Hospital

    FUNAYAMA Emi, YAMAMOTO Yuhei, OYAMA Akihiko, FURUKAWA Hiroshi, HAYASHI Toshihiko

    31 ( 9 )   619 - 627   2011.9

    　More details

    Language：Japanese  

    researchmap

  • PRELIMINARY REPORT OF PREOPERATIVE ASSESSMENT OF ANTEROLATERAL THIGH FLAP PERFORATORS USING REAL-TIME VIRTUAL SONOGRAPHY SYSTEM Reviewed

    Akira Saito, Hiroshi Furukawa, Toshihiko Hayashi, Akihiko Oyama, Emi Funayama, Yuhei Yamamoto

    MICROSURGERY   31 ( 6 )   499 - 501   2011.9

    　More details

  • 顔面神経信号入力変化をmRNA発現で捉える 顔面神経障害の定量的評価

    蕨 雄大, 齋藤 亮, 林 利彦, 古川 洋志, 山本 有平, 七戸 龍司

    日本形成外科学会会誌   31 ( 9 )   667 - 667   2011.9

    　More details

    Language：Japanese   Publisher：(一社)日本形成外科学会  

    researchmap

  • 神経縫合後の顔面表情筋mRNA発現変化についての基礎研究

    蕨 雄大, 七戸 龍司, 齋藤 亮, 林 利彦, 古川 洋志, 山本 有平

    日本マイクロサージャリー学会会誌   24 ( 2 )   121 - 121   2011.7

    　More details

    Language：Japanese   Publisher：(一社)日本マイクロサージャリー学会  

    researchmap

  • こだわりのSuper microsurgery 基礎研究に生かすSuper microsurgery

    古川 洋志, 大澤 昌之, 七戸 龍司, 齋藤 亮, 林 利彦, 山本 有平

    日本マイクロサージャリー学会会誌   24 ( 2 )   69 - 69   2011.7

    　More details

    Language：Japanese   Publisher：(一社)日本マイクロサージャリー学会  

    researchmap

  • Network型再建による耳下腺癌切除後の顔面神経の即時再建

    古川 洋志, 齋藤 亮, 林 利彦, 大澤 昌之, 池田 正起, 蕨 雄大, 山本 有平, 七戸 龍司, 関堂 充

    日本形成外科学会会誌   31 ( 7 )   502 - 502   2011.7

    　More details

    Language：Japanese   Publisher：(一社)日本形成外科学会  

    researchmap

  • 遊離腓骨皮弁を用いた下顎再建と義歯装着までの一貫治療

    林 利彦, 古川 洋志, 斎藤 亮, 秦 浩信, 野谷 健一, 山本 有平

    日本マイクロサージャリー学会会誌   24 ( 2 )   111 - 111   2011.7

    　More details

    Language：Japanese   Publisher：(一社)日本マイクロサージャリー学会  

    researchmap

  • Ethanol sclerotherapy with &apos;injection and aspiration technique&apos; for giant lymphatic malformation in adult cases Reviewed

    Hiroshi Furukawa, Satoru Sasaki, Akihiko Oyama, Toshihiko Hayashi, Emi Funayama, Noriko Saito, Yuhei Yamamoto

    JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY   64 ( 6 )   809 - 811   2011.6

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.bjps.2010.09.003

    Web of Science

    PubMed

    researchmap

  • 下顎再建の新しい工夫 遊離腓骨皮弁を用いた下顎再建と義歯装着までの一貫治療 歯科的視点と形成外科的視点から考えた下顎再建

    林 利彦, 古川 洋志, 斎藤 亮, 秦 浩信, 野谷 健一, 山本 有平

    日本頭蓋顎顔面外科学会誌   27 ( 2 )   99 - 100   2011.6

    　More details

    Language：Japanese   Publisher：(一社)日本頭蓋顎顔面外科学会  

    researchmap

  • Microsurgical Lymphaticovenous Implantation Targeting Dermal Lymphatic Backflow Using Indocyanine Green Fluorescence Lymphography in the Treatment of Postmastectomy Lymphedema Reviewed

    Hiroshi Furukawa, Masayuki Osawa, Akira Saito, Toshihiko Hayashi, Emi Funayama, Akihiko Oyama, Mitsuru Sekido, Yuhei Yamamoto

    PLASTIC AND RECONSTRUCTIVE SURGERY   127 ( 5 )   1804 - 1811   2011.5

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1097/PRS.0b013e31820cf2e2

    Web of Science

    PubMed

    researchmap

  • 脈絡膜原発悪性黒色腫の肝転移巣に対する肝動脈動注・塞栓療法について

    大芦 孝平, 林 利彦, 古川 洋志, 山本 有平, 阿保 大介, 作原 祐介, 堤田 新

    日本形成外科学会会誌   31 ( 5 )   342 - 342   2011.5

    　More details

    Language：Japanese   Publisher：(一社)日本形成外科学会  

    researchmap

  • 初発遠隔転移が肺であった悪性黒色腫症例の検討

    七戸 龍司, 古川 洋志, 林 利彦, 山本 有平, 堤田 新

    日本形成外科学会会誌   31 ( 5 )   342 - 342   2011.5

    　More details

    Language：Japanese   Publisher：(一社)日本形成外科学会  

    researchmap

  • Our refinements in microtia reconstruction for the improvement of aesthetic outcome

    Akihiko Oyama, Hiroshi Furukawa, Emi Funayama, Toshihiko Hayashi, Akira Saito, Yuhei Yamamoto

    Japanese Journal of Plastic Surgery   54 ( 3 )   243 - 250   2011.3

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)  

    Scopus

    researchmap

  • How Do the Type and Location of a Vascular Malformation Influence Growth in Klippel-Trenaunay Syndrome? Reviewed

    Emi Funayama, Satoru Sasaki, Akihiko Oyama, Hiroshi Furukawa, Toshihiko Hayashi, Yuhei Yamamoto

    PLASTIC AND RECONSTRUCTIVE SURGERY   127 ( 1 )   340 - 346   2011.1

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1097/PRS.0b013e3181f95b4c

    Web of Science

    PubMed

    researchmap

  • A New Modified Technique for Removing Epidermal Cysts Using a Trepan in One Stage with a Smaller Postoperative Scar and No Recurrence Reviewed

    Emi Funayama, Akihiko Oyama, Hiroshi Furukawa, Toshihiko Hayashi, Mariko Sugino, Yuhei Yamamoto

    DERMATOLOGIC SURGERY   36 ( 12 )   2050 - 2052   2010.12

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/j.1524-4725.2010.01774.x

    Web of Science

    PubMed

    researchmap

  • A false-negative sentinel lymph node in the parotid gland of a melanoma patient: a new algorithm for SLN biopsy in the parotid gland Reviewed

    Toshihiko Hayashi, Hiroshi Furukawa, Arata Tsutsumida, Tetsunori Yoshida

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   15 ( 5 )   504 - 507   2010.10

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s10147-010-0063-8

    Web of Science

    PubMed

    researchmap

  • 頭頸部メラノーマの治療における近赤外線カメラを用いたICG蛍光リンパ管造影所見の検討

    古川 洋志, 林 利彦, 大澤 昌之, 七戸 龍司, 大芦 孝平, 山本 有平, 高澤 啓

    日本皮膚悪性腫瘍学会学術大会プログラム・抄録集   26回   183 - 183   2010.6

    　More details

    Language：Japanese   Publisher：(一社)日本皮膚悪性腫瘍学会  

    researchmap

  • 低蛋白血症が原因と推察された熱傷術後の創傷治癒遅延

    蕨 雄大, 大野 健太郎, 池田 正起, 大芦 耕平, 七戸 龍司, 林 利彦, 舟山 恵美, 山本 有平

    熱傷   36 ( 2 )   108 - 109   2010.6

    　More details

    Language：Japanese   Publisher：(一社)日本熱傷学会  

    researchmap

  • マイクロサージャリーのトレーニングモデルの理想と現実 動物実験とビデオプレゼンテーションの有用性

    古川 洋志, 前田 拓, 大芦 孝平, 七戸 龍司, 大澤 昌之, 齋藤 亮, 林 利彦, 山本 有平, 関堂 充

    日本マイクロサージャリー学会会誌   23 ( 2 )   107 - 108   2010.6

    　More details

    Language：Japanese   Publisher：(一社)日本マイクロサージャリー学会  

    researchmap

  • 肝転移に対して抗癌剤動注・塞栓療法を行った脈絡膜メラノーマの治療経験

    大芦 孝平, 林 利彦, 古川 洋志, 山本 有平, 阿保 大介, 作原 祐介

    日本皮膚悪性腫瘍学会学術大会プログラム・抄録集   26回   121 - 121   2010.6

    　More details

    Language：Japanese   Publisher：(一社)日本皮膚悪性腫瘍学会  

    researchmap

  • 頭頸部悪性黒色腫の治療における近赤外線カメラを用いたICG蛍光リンパ管造影所見の検討

    古川 洋志, 林 利彦, 大澤 昌之, 七戸 龍司, 大芦 孝平, 山本 有平, 高澤 啓

    頭頸部癌   36 ( 2 )   171 - 171   2010.5

    　More details

    Language：Japanese   Publisher：(一社)日本頭頸部癌学会  

    researchmap

  • Immediate reconstruction of total facial nerve plexus after radical total parotidectomy : Facial-hypoglossal network system based on neural signal augmentation

    FURUKAWA Hiroshi, SAITO Akira, HAYASHI Toshihiko, YAMAMOTO Yuhei, HOMMA Akihiro, FUKUDA Satoshi, FURUTA Yasushi, SEKIDO Mitsuru

    Toukeibu Gan   35 ( 3 )   217 - 222   2009.10

    　More details

    Language：Japanese  

    DOI： 10.5981/jjhnc.35.217

    researchmap

  • Preliminary feasibility study of S-1 as adjuvant chemotherapy for patients with advanced skin cancer

    TSUTSUMIDA Arata, YAMAMOTO Akifumi, FURUKAWA Hiroshi, HAYASHI Toshihiko, YOSHIDA Tetsuya, MINAGAWA Tomohiro, YAMAMOTO Yuhei

    Skin Cancer   24 ( 2 )   301 - 304   2009.10

    　More details

    Language：Japanese   Publisher：The Japanese Skin Cancer Society  

    We conducted this preliminary study to determine the feasibility of adjuvant therapy administration schedule of S-1 for locoregionally advanced non-melanoma skin cancers (squamous cell carcinoma, apocrine adenocarcinoma, eccrine porocarcinoma, extramammary Paget&#039;s disease). Five patients receiving definitive treatments were enrolled to receive oral S-1 for 2-weeks&#039; administration followed by a 2-week rest for 12 months.The cumulative rates of the relative total administration dose of S-1 at 100% were 80% (4/5). Adverse events were not severe. The incidences of neutropenia (Grade 1) and skin...

    DOI： 10.5227/skincancer.24.301

    researchmap

  • Problems and solutions of mandibular distraction osteogenesis in the treatment for hemifacial microsomia and treacher-collins syndrome

    Satoru Sasaki, Masayuki Osawa, Akihiko Oyama, Kunihiro Kawashima, Yoshiaki Sato, Toru Okamoto, Toshihiko Hayashi, Yuhei Yamamoto

    Japanese Journal of Plastic Surgery   52 ( 9 )   1051 - 1062   2009.9

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)  

    Scopus

    researchmap

  • Correction of involutional entropion using a rhytidoplasty technique Reviewed

    Masatsugu Kondo, Hidehiko Minakawa, Emi Funayama, Toshihiko Hayashi

    European Journal of Plastic Surgery   32 ( 4 )   181 - 184   2009.8

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s00238-009-0336-5

    Scopus

    researchmap

  • 血管内皮細胞における硬化剤の作用に関する研究:最終報告

    William Mol, 長尾 宗朝, 斉藤 亮, 斉藤 典子, 林 利彦, 畠 真也, 古川 洋志, 佐々木 了, 山本 有平, 外丸 詩野

    日本形成外科学会会誌   28 ( 5 )   348 - 348   2008.5

    　More details

    Language：Japanese   Publisher：(一社)日本形成外科学会  

    researchmap

  • Evaluation of the sclerotherapeutic efficacy of ethanol, polidocanol, and OK-432 using an in vitro model Reviewed

    William Mol, Hiroshi Furukawa, Satoru Sasaki, Utano Tomaru, Toshihiko Hayashi, Akira Saito, Munetomo Nagao, Noriko Saito, Shinya Hata, Yuhei Yamamoto

    DERMATOLOGIC SURGERY   33 ( 12 )   1452 - 1459   2007.12

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/j.1524-4725.2007.33315.x

    Web of Science

    PubMed

    researchmap

  • 複数回の手術を要した乳癌術後放射線潰瘍の1例

    大澤 昌之, 関堂 充, 長尾 宗朝, 斉藤 典子, 古川 洋志, 山本 有平, 林 利彦, 冨士森 英之

    日本マイクロサージャリー学会会誌   20 ( 2 )   223 - 223   2007.6

    　More details

    Language：Japanese   Publisher：(一社)日本マイクロサージャリー学会  

    researchmap

  • 下顎骨延長術20例の中期成績の検討(第一報) Hemifacial microsomia症例の延長後の後戻りについて

    大澤 昌之, 佐々木 了, 小山 明彦, 長尾 宗朝, 山本 有平, 佐藤 嘉晃, 岡本 亨, 川嶋 邦裕, 林 利彦

    日本頭蓋顎顔面外科学会誌   23 ( 2 )   132 - 132   2007.6

    　More details

    Language：Japanese   Publisher：(一社)日本頭蓋顎顔面外科学会  

    researchmap

  • New grading system for patients with Treacher Collins syndrome Reviewed

    Toshihiko Hayashi, Satoru Sasaki, Akihiko Oyama, Kunihiro Kawashima, Katsumi Horiuchi, Mol William, Yuhei Yamamoto

    JOURNAL OF CRANIOFACIAL SURGERY   18 ( 1 )   113 - 119   2007.1

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1097/SCS.0b013e31802cf3ff

    Web of Science

    PubMed

    researchmap

  • PLASTIC SURGERY TECHNIQUE IN HEAD AND NECK RECONSTRUCTION-DONOR SITE CLOSURE AND SECONDARY REVISION

    SEKIDO Mitsuru, FURUKAWA Hiroshi, HAYASHI Toshihiko, YAMAMOTO Yuhei, MINAMIMOTO Toshiyuki

    Toukeibu Gan   32 ( 3 )   241 - 246   2006.10

    　More details

    Language：Japanese  

    DOI： 10.5981/jjhnc.32.241

    researchmap

  • DIEP(深下腹壁動脈穿通枝)皮弁を用いた頭頸部再建

    関堂 充, 長尾 宗朝, 古川 洋志, 矢島 和宜, 林 利彦, 山本 有平

    頭頸部癌   32 ( 2 )   169 - 169   2006.5

    　More details

    Language：Japanese   Publisher：(一社)日本頭頸部癌学会  

    researchmap

  • Surgical management of ischial and perineal pressure ulcers with urethrocutaneous fistulae.

    T. Hayashi, M. Murazumi, W. Mol, Y. Yamamoto

    Journal of wound care   15 ( 2 )   55 - 57   2006

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.12968/jowc.2006.15.2.26893

    Scopus

    PubMed

    researchmap

  • Treatment of ischial pressure sores by means of sclerotherapy using absolute ethanol Reviewed

    T Hayashi, K Honda, C Kimura, Y Yamamoto, A Oyama, T Sugihara

    ANNALS OF PLASTIC SURGERY   53 ( 6 )   554 - 559   2004.12

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1097/01.sap.0000134648.16439.0c

    Web of Science

    PubMed

    researchmap

  • A case of angiosarcoma of the scalp treated by wide local excision

    KIMURA Chu, FUNAYAMA Emi, FURUYA Kazuhiko, YOKOYAMA Tomoko, HAYASHI Toshihiko

    Skin Cancer   18 ( 1 )   51 - 55   2003.5

    　More details

    Language：Japanese   Publisher：The Japanese Skin Cancer Society  

    Angiosarcoma of the scalp is a relatively rare malignant endothelial tumor. We experienced a case of angiosarcoma treated by wide local excision. An 85-year-old man was admitted to our hospital with a tumor which had appeared 1 month before on his left temporal region. The diagnosis of angiosarcoma was made based on the clinical features and histopathological finding of the lesions on the skin by a former institution. We performed wide local excision immediately circumferentially to a distance of more than 3-5cm from the tumor margin. At present, 13 months after surgery, no recurrence or metastasis has been observed. [<i>Skin Cancer (Japan)</i> 2003; 18: 51-55]

    DOI： 10.5227/skincancer.18.51

    CiNii Books

    researchmap

    Other Link： http://search.jamas.or.jp/link/ui/2003264892

▼display all

Books

  • 標準形成外科学 第8版

    （ Role： Contributor皮膚皮下腫瘍：悪性腫瘍）

    医学書院  2025.2 

    　More details

  • 北海道の病院2025

    （ Role： Contributor形成外科）

    北海道新聞社  2025.2 

    　More details

  • 形成外科治療手術手技全書V

    （ Role： Contributor第6章リンパ節郭清：センチネルリンパ節生検）

    克誠堂出版  2018.4 

    　More details

  • 形成外科治療手術手技全書Ⅴ：腫瘍・母斑・血管奇形

    （ Role： Contributor第6章 リンパ節郭清：センチネルリンパ節生検）

    2018.4 

    　More details

  • 局所皮弁 第1巻 顔面・頸部・体幹

    （ Role： Contributor肩甲部・背部）

    克誠堂出版  2017.12 

    　More details

  • TEXT形成外科 改訂3版

    （ Role： Contributor腫瘍：皮膚悪性腫瘍）

    南山堂  2017.3 

    　More details

▼display all

MISC

  • 私の心に残る1症例(No.51)

    林 利彦

    形成外科   68 ( 1 )   67 - 69   2025.1

    　More details

  • 双茎皮弁を用いて再建した、皮膚浸潤を伴う回腸人工肛門部癌の治療経験

    西尾 卓哉, 山尾 健, 宮田 明久生, 市原 寛大, 宮田 夏実, 庄中 達也, 上小倉 佑機, 青木 直子, 谷野 美智枝, 林 利彦

    日本臨床皮膚外科学会総会・学術大会・瘢痕・ケロイド治療研究会プログラム・抄録集   41回・18回   60 - 60   2023.5

    　More details

    Language：Japanese   Publisher：日本臨床皮膚外科学会・瘢痕・ケロイド治療研究会  

    researchmap

  • 【随想】 思い返すと

    林 利彦

    形成外科   66   135   2023

    　More details

    Authorship：Lead author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)   Publisher：克誠堂出版  

    researchmap

  • 教室だより北〜南

    林利彦

    形成外科   66 ( 6 )   728 - 731   2023

    　More details

    Authorship：Lead author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)   Publisher：克誠堂出版  

    researchmap

  • JSW scar scale(JSS)を用いたケロイド・肥厚性瘢痕治療アルゴリズム

    小川 令, 土佐 泰祥, 今井 裕季子, 岡部 圭介, 赤石 諭史, 長尾 宗朝, 林 利彦

    瘢痕・ケロイド治療ジャーナル   ( 15 )   33 - 39   2021.7

    　More details

    Language：Japanese   Publisher：(株)全日本病院出版会  

    researchmap

  • プロからプロへ：体表の悪性黒色腫に対する連続切除（郭清術）の適応・コツは？

    林利彦

    医事新報   2021

    　More details

    Authorship：Lead author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)   Publisher：日本医事新報社  

    researchmap

  • ケロイド・肥厚性瘢痕治療―アルゴリズム作成における問題点―

    林利彦

    瘢痕・ケロイド治療ジャーナル   2021

    　More details

    Authorship：Lead author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)   Publisher：全日本病院出版会  

    researchmap

  • 頭皮原発血管肉腫に対する化学療法および強度変調放射線照射による集学的治療の有用性

    前田 拓, 北條 正洋, 林 利彦, 山本 有平, 安田 耕一

    日本皮膚悪性腫瘍学会学術大会プログラム・抄録集   36回   153 - 153   2020.12

    　More details

    Language：Japanese   Publisher：(一社)日本皮膚悪性腫瘍学会  

    researchmap

  • 肝細胞癌術後に右下腿骨格筋転移をきたした1例

    南波 宏征, 神山 俊哉, 横尾 英樹, 折茂 達也, 島田 慎吾, 長津 明久, 大畑 多嘉宣, 蒲池 浩文, 林 利彦, 新井 隆太, 桑原 健, 武冨 紹信

    日本外科学会定期学術集会抄録集   119回   RS - 5   2019.4

    　More details

    Language：Japanese   Publisher：(一社)日本外科学会  

    researchmap

  • Evaluation of dog and cat bites in our hospital

    Toshiyuki Minamimoto, Susumu Honda, Kikuo Nakashima, Kosuke Ishikawa, Toshihiko Hayashi

    Hakodate Medical Journal   42 ( 1 )   50 - 53   2018.10

    　More details

  • 外科療法を行った放射線性下顎骨骨髄炎の臨床的検討

    佐藤 明, 吉川 和人, 宮腰 昌明, 林 利彦, 北川 善政

    頭頸部癌   44 ( 2 )   185 - 185   2018.5

    　More details

    Language：Japanese   Publisher：(一社)日本頭頸部癌学会  

    researchmap

  • 【顔面神経麻痺の治療アルゴリズム:ベストプラクティス】 当教室の顔面神経麻痺に対する外科治療のアルゴリズム

    古川 洋志, 大澤 昌之, 小山 明彦, 村尾 尚規, 林 利彦, 舟山 恵美, 山本 有平

    日本頭蓋顎顔面外科学会誌   34 ( 1 )   16 - 20   2018.4

    　More details

    Language：Japanese   Publisher：(一社)日本頭蓋顎顔面外科学会  

    researchmap

  • Horse‐related Facial Injuries at Our Institution: Report of 4 Cases

    藤田宗純, 小山明彦, 大澤昌之, 村尾尚規, 林利彦, 舟山恵美, 山本有平

    日本頭蓋顎顔面外科学会誌   33 ( 3 )   87‐92   2017.9

    　More details

    Language：Japanese  

    J-GLOBAL

    researchmap

  • 口腔がん再建術後に中心静脈カテーテル関連深部静脈血栓症を生じた2例 DVTに対する歯科医師の対応について

    秦 浩信, 佐藤 明, 宮腰 昌明, 吉川 和人, 清水 六花, 林 利彦, 箕輪 和行, 北川 善政

    日本口腔腫瘍学会誌   29 ( 1 )   1 - 8   2017.3

    　More details

    Language：Japanese   Publisher：(一社)日本口腔腫瘍学会  

    DOI： 10.5843/jsot.29.1

    researchmap

  • 【ケロイド・肥厚性瘢痕の治療-我が施設(私)のこだわり-】 <保存的治療編>完遂を目指したオーダーメイド治療 北海道大学(保存的治療)

    林 利彦, 村尾 尚規, 山本 有平

    PEPARS   ( 117 )   42 - 47   2016.9

    　More details

    Language：Japanese   Publisher：(株)全日本病院出版会  

    researchmap

  • 【ケロイド・肥厚性瘢痕の治療-我が施設(私)のこだわり-】 <外科的治療編>ケロイドの再発制御を目指した外科的治療と術後補助療法 北海道大学(外科的治療)

    村尾 尚規, 林 利彦, 山本 有平

    PEPARS   ( 117 )   94 - 100   2016.9

    　More details

    Language：Japanese   Publisher：(株)全日本病院出版会  

    researchmap

  • ケロイド・肥厚性瘢痕切除後の電子線照射とステロイド局注療法に関する考察 患者アンケート調査を通じて

    池田 正起, 林 利彦, 村尾 尚規, 舟山 恵美, 小山 明彦, 山本 有平

    瘢痕・ケロイド治療ジャーナル   ( 10 )   1 - 6   2016.8

    　More details

    Language：Japanese   Publisher：(株)全日本病院出版会  

    researchmap

  • 自家培養表皮が効果的となりうる症例の選択 北海道大学病院における5年間の広範囲熱傷症例の検討

    藤田 宗純, 村尾 尚規, 山尾 健, 七戸 龍司, 林 利彦, 舟山 恵美, 小山 明彦, 古川 洋志, 山本 有平

    熱傷   42 ( 2 )   64 - 70   2016.6

    　More details

    Language：Japanese   Publisher：(一社)日本熱傷学会  

    researchmap

  • 当科における色素性母斑のレーザー治療

    伊藤 梨里, 小山 明彦, 佐々木 了, 舟山 恵美, 古川 洋志, 林 利彦, 山本 有平

    日本レーザー医学会誌   36 ( 4 )   529 - 529   2016.1

    　More details

    Language：Japanese   Publisher：(NPO)日本レーザー医学会  

    researchmap

  • 当院で経験した舌小帯短縮症家系内発症例について

    南本 俊之, 足立 真紀, 依田 弥奈子, 佐久間 智子, 石川 耕資, 林 利彦

    函館医学誌 = Hakodate medical journal   39 ( 1 )   10 - 12   2015.11

    　More details

    Language：Japanese   Publisher：市立函館病院  

    舌小帯短縮症は，2?5％ほどの発生頻度を有する舌の先天異常で1），胎生期における舌原基と下顎歯槽粘膜の分離不全と，生後の舌小帯の短縮障害が加わって成立するとされている2）。その家系内発症はいくつかの報告があるに過ぎない。今回当院で舌小帯短縮症の家族例を経験したので，若干の考察を加えて報告する。

    researchmap

    Other Link： http://search.jamas.or.jp/link/ui/2016105683

  • 皮膚軟部悪性腫瘍に対する再建術の考え方 (特集 皮膚外科のための皮膚軟部腫瘍診断の基礎) -- (外科的治療)

    林 利彦, 山本 有平

    Pepars   ( 100 )   126 - 131   2015.4

    　More details

    Language：Japanese   Publisher：全日本病院出版会  

    CiNii Books

    researchmap

    Other Link： http://search.jamas.or.jp/link/ui/2015208416

  • ニボルマブ投与後に筋炎を発症した左足部悪性黒色腫の1例

    七戸龍司, 古川洋志, 林利彦, 村尾尚規, 山本有平, 志田玄貴, 須田剛生

    日本皮膚悪性腫瘍学会学術大会プログラム・抄録集   31st   147   2015

    　More details

    Language：Japanese  

    J-GLOBAL

    researchmap

  • Marchac Frontal Modelを用いたCraniosynostosis頭蓋形成~その有用性とわれわれの工夫~

    小山明彦, 古川洋志, 舟山恵美, 林利彦, 山本有平, 黒田敏, 中山若樹

    日本形成外科学会会誌   34 ( 10 )   780   2014.10

    　More details

    Language：Japanese  

    J-GLOBAL

    researchmap

  • 特異な臨床像を呈したMadelung病(両側対称性脂肪腫症)の1例

    伊藤 梨里, 舟山 恵美, 林 利彦, 古川 洋志, 小山 明彦, 山本 有平

    日本形成外科学会会誌   34 ( 4 )   311 - 311   2014.4

    　More details

    Language：Japanese   Publisher：(一社)日本形成外科学会  

    researchmap

  • 片側唇顎口蓋裂に対する一期手術 全16例の短期経過

    小山 明彦, 舟山 恵美, 古川 洋志, 林 利彦, 山本 有平, 岡本 亨, 西澤 典子, 今井 智子, 佐藤 嘉晃

    日本形成外科学会会誌   33 ( 11 )   865 - 865   2013.11

    　More details

    Language：Japanese   Publisher：(一社)日本形成外科学会  

    researchmap

  • フッ化水素アンモニウムによる化学熱傷の1治療経験

    南本 俊之, 石川 耕資, 小田桐 正彦, 岩井 里子, 林 利彦

    函館医学誌 = Hakodate medical journal   37 ( 1 )   23 - 25   2013.10

    　More details

    Language：Japanese   Publisher：市立函館病院  

    researchmap

  • A New Uniform Protocol of Combined Corticosteroid Injections and Ointment Application Reduces Recurrence Rates After Surgical Keloid/ Hypertrophic Scar Excision

    林 利彦, 村尾 尚規, 山本 有平

    北海道醫學雜誌 = Acta medica Hokkaidonensia   88 ( 4 )   156 - 156   2013.9

    　More details

    Language：Japanese  

    researchmap

  • 遊離肩甲骨・肩甲皮弁(下顎再建を中心に) (特集 マイクロサージャリーにおける合併症とその対策) -- (各種皮弁における合併症)

    古川 洋志, 林 利彦, 山本 有平

    Pepars   ( 80 )   81 - 86   2013.8

    　More details

    Language：Japanese   Publisher：全日本病院出版会  

    CiNii Books

    researchmap

    Other Link： http://search.jamas.or.jp/link/ui/2014071448

  • Flap Reconstruction for Patients with Blood Coagulation Disorders

    56 ( 5 )   505 - 511   2013.5

    　More details

  • 頬部原発の黒色腫 : 整容面を考慮したOncoplastic Surgery (特集 Oncoplastic Skin Surgery : 私ならこう治す!)

    古川 洋志, 林 利彦, 山本 有平

    Pepars   ( 76 )   46 - 49   2013.4

    　More details

    Language：Japanese   Publisher：全日本病院出版会  

    CiNii Books

    researchmap

    Other Link： http://search.jamas.or.jp/link/ui/2013222885

  • Muir-Torre syndromeに合併した鼻尖部有棘細胞癌の治療経験

    池田 正起, 古川 洋志, 山本 有平, 齋藤 亮, 林 利彦, 久保田 佳奈子, 山田 洋介

    日本形成外科学会会誌   33 ( 4 )   281 - 281   2013.4

    　More details

    Language：Japanese   Publisher：(一社)日本形成外科学会  

    researchmap

  • 手指のALMの切除範囲と再建における考え方

    古川 洋志, 林 利彦, 村尾 尚規, 大芦 孝平, 山本 有平, 堤田 新, 関堂 充, 吉田 哲憲

    Skin Cancer   28 ( 2 )   145 - 146   2013

    　More details

    Language：Japanese   Publisher：The Japanese Skin Cancer Society  

    DOI： 10.5227/skincancer.28.145

    researchmap

  • Preliminary report of preoperative assessment of anterolateral thigh flap perforators using real-time virtual sonography system

    87 ( 6 )   264 - 264   2012.11

    　More details

    Language：Japanese  

    CiNii Books

    researchmap

  • Case Report of Basal Cell Adenoma in the Parotid Gland with a Difficult Preoperative Diagnosis

    IKEDA Masaki, HAYASHI Toshihiko, YAMAMOTO Yuhei

    32 ( 10 )   739 - 744   2012.10

    　More details

    Language：Japanese  

    CiNii Books

    researchmap

  • メラノーマ治療成績向上を目指して ～ヒアルロン酸修飾インターフェロンβ 徐放剤の開発－第1 報－ Reviewed

    山尾健, 古川洋志, 斉藤亮, 大澤昌之, 林利彦, 田畑泰彦, 山本有平

    第21 回日本形成外科学会基礎学術集 会（2012.10.4－5．福島）   2012

    　More details

    Language：Japanese  

    researchmap

  • Muir-Torre症候群に合併した鼻尖部有棘細胞癌の治療経験

    池田 正起, 古川 洋志, 山本 有平, 齋藤 亮, 林 利彦, 久保田 佳奈子, 山田 洋介

    日本皮膚悪性腫瘍学会学術大会プログラム・抄録集   27回   167 - 167   2011.6

    　More details

    Language：Japanese   Publisher：(一社)日本皮膚悪性腫瘍学会  

    researchmap

  • 口蓋裂二次手術としてのFurlow法 鼻腔ファイバースコープ所見に基づく適応判断

    小山 明彦, 舟山 恵美, 古川 洋志, 林 利彦, 山本 有平, 西澤 典子

    日本形成外科学会会誌   31 ( 5 )   344 - 344   2011.5

    　More details

    Language：Japanese   Publisher：(一社)日本形成外科学会  

    researchmap

  • 口蓋裂二次手術としてのFurlow法 鼻腔ファイバースコープ所見に基づく適応判断について

    小山 明彦, 西澤 典子, 佐々木 了, 舟山 恵美, 林 利彦, 大澤 昌之, 山本 有平

    日本頭蓋顎顔面外科学会誌   26 ( 2 )   143 - 143   2010.6

    　More details

    Language：Japanese   Publisher：(一社)日本頭蓋顎顔面外科学会  

    researchmap

  • 当科における口腔癌の下顎広範切除例に対する顎堤形成術

    秦浩信, 村田翼, 佐藤明, 山崎裕, 野谷健一, 黒嶋伸一郎, 小野木宏仲, 野谷健治, 林利彦, 古川洋志, 北川善政

    頭けい部癌   36 ( 2 )   226   2010.5

    　More details

    Language：Japanese  

    J-GLOBAL

    researchmap

  • Treatment for senile blepharoptosis with skin resection ; review of the width of excised skin by age bracket

    Masatsugu Kondo, Hidehiko Minakawa, Emi Funayama, Toshihiko Hayashi

    Japanese Journal of Plastic Surgery   53 ( 1 )   73 - 78   2010.1

    　More details

    Language：Japanese   Publishing type：Book review, literature introduction, etc.  

    Scopus

    researchmap

  • Skin suture and paper taping: wound care after surgical operations

    Clinical orthopaedic surgery   44 ( 8 )   773 - 777   2009.8

    　More details

  • 北海道がんセンターにおける過去14年間の悪性黒色腫90例の検討

    山根 尚子, 加藤 直子, 大澤 倫子, 柳 輝希, 伊藤 幹, 西村 真智子, 皆川 英彦, 舟山 恵美, 林 利彦, 夏賀 健

    日本皮膚科学会雑誌   118 ( 10 )   2024 - 2024   2008.9

    　More details

    Language：Japanese   Publisher：(公社)日本皮膚科学会  

    researchmap

  • Decreased prostaglandin E-2 production by inflammatory cytokine and lower expression of EP2 receptor result in increased collagen synthesis in keloid fibroblasts

    Toshihiko Hayashi, Jun Nishihira, Yoshikazu Koyama, Satoru Sasaki, Yuhei Yamamoto

    JOURNAL OF INVESTIGATIVE DERMATOLOGY   126 ( 5 )   990 - 997   2006.5

    　More details

  • Our modification of operation technique for microform cleft lip

    OYAMA Akihiko

    31 ( 2 )   2006.4

    　More details

    Language：Japanese  

    researchmap

  • Midface distraction on craniofacial dysostosis; a preliminary review

    Akihiko Oyama, Kunihiro Kawashima, Hiroharu Igawa, Satoru Sasaki, Toshihiko Hayashi, Keiko Amagai, Yuhei Ymamoto, Toru Okamoto

    Japanese Journal of Plastic and Reconstructive Surgery   49 ( 3 )   291 - 299   2006.3

    　More details

    Language：Japanese   Publishing type：Book review, literature introduction, etc.  

    Scopus

    researchmap

  • Surgical Treatment of Massive Arteriovenous Malformation with Application of Hypothermia and Cardiopulmonary Bypass

    YAMAMOTO Yuhei, SUGIHARA Tsuneki, MINAKAWA Hidehiko, OHKUBO Yoshiko, HAYASHI Toshihiko

    16 ( 12 )   863 - 871   1996.12

    　More details

    Language：Japanese  

    CiNii Books

    researchmap

▼display all

Presentations

  • シンポジウム2 ニッポンの形成外科へ：足病の未来を託す〜足病患者の救肢の限界に挑む〜 Invited International conference

    林 利彦

    第67回日本形成外科学会総会・学術集会  2024.4 

    　More details

    Event date： 2024.4

    Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

    researchmap

  • 皮膚腫瘍外科分野指導医（教育セミナー）: 皮膚リンパ流の特徴と臨床応用 Invited International conference

    林 利彦

    第67回日本形成外科学会総会・学術集会  2024.4 

    　More details

    Event date： 2024.4

    Language：Japanese   Presentation type：Oral presentation (invited, special)  

    researchmap

  • オープニングリマークス：CLTI Conference for Wound Care Specialists in Hokkaido Invited

    林 利彦

    CLTI Conference for Wound Care Specialists in Hokkaido  2024.3 

    　More details

    Event date： 2024.3

    Language：Japanese   Presentation type：Oral presentation (keynote)  

    researchmap

  • スポンサードハンズオンセミナー2.：縫合技術の真髄を知る ―実践ですぐに使える縫合テクニックを学ぶ― Invited

    林利彦

    第39回日本皮膚悪性腫瘍学会学術集会  2023.8 

    　More details

    Event date： 2023.8

    Language：Japanese   Presentation type：Oral presentation (invited, special)  

    researchmap

  • シンポジウム：顔面皮膚悪性腫瘍手術に対するAesthetic mind Invited

    林 利彦

    第40回日本頭蓋顎顔面外科学会学術集会  2022.11 

    　More details

    Event date： 2022.11

    Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

    researchmap

  • シンポジウム１4【形成外科領域における近赤外線の応用】近赤外線カメラシステムを応用した皮膚悪性腫瘍の外科手術と臨床研究

    林 利彦

    第65回日本形成外科学会総会・学術大会 

    　More details

    Event date： 2022.4

    Language：English   Presentation type：Symposium, workshop panel (public)  

    researchmap

  • Planning Program, Scar Therapy 1:Long-term outcomes and recurrence-free interval after the treatment of keloids with a standardized protocol International conference

    林 利彦

    The 2nd World Congress of Global Scar Society with Scar Academy and Japan Scar Workshop 

    　More details

    Event date： 2021.12

    Language：English   Presentation type：Oral presentation (invited, special)  

    researchmap

  • 招待講演：頭頸部癌切除後の各種再建法と機能について

    林 利彦

    第98回北北海道耳鼻咽喉科懇話会 

    　More details

    Event date： 2021.12

    Language：Japanese   Presentation type：Oral presentation (invited, special)  

    researchmap

  • シンポジウム7【マイクロサージャリーを用いた頭頸部再建後の長期経過 - 下顎再建】高齢者の下顎骨再建における遊離腓骨移植後の骨吸収に関する検討

    林 利彦

    第48回日本マイクロサージャリー学会学術集会 

    　More details

    Event date： 2021.12

    Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

    researchmap

  • 北海道大学歯学部口腔外科同門会web講演会：進行性皮膚悪性腫瘍の外科治療 ―顔面の再建を中心として―

    林 利彦

    北海道大学歯学部口腔外科同門会web講演会 

    　More details

    Event date： 2021.9

    Language：Japanese   Presentation type：Oral presentation (invited, special)  

    researchmap

  • セミナー講演：進行性皮膚悪性腫瘍の外科治療 ―顔面の再建を中心として―

    林 利彦

    旭川医科大学腫瘍センターセミナー 

    　More details

    Event date： 2021.8

    Language：Japanese   Presentation type：Oral presentation (invited, special)  

    researchmap

  • web講演会：皮膚悪性腫瘍治療における形成外科の役割 ―形成外科はどの領域で貢献できるか―

    林利彦

    ノバルティスweb講演会 

    　More details

    Event date： 2021.4

    Language：Japanese   Presentation type：Oral presentation (invited, special)  

    researchmap

  • シンポジウム１【皮膚悪性腫瘍治療における形成外科の役割】 悪性黒色腫の切除から再建まで ―外科手術と新しい薬物療法のコラボレーション―

    林利彦

    第36回日本皮膚悪性腫瘍学会学術大会 

    　More details

    Event date： 2021.1

    Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

    researchmap

  • シンポジウム：CLTI患者の難治性潰瘍に対する遊離組織移植：血管外科とのチーム医療

    林 利彦

    第30回日本形成外科手術手技学会  2025.3 

    　More details

    Presentation type：Symposium, workshop panel (public)  

    researchmap

  • 特別講演：頭頸部皮膚リンパ流の特徴と 顔面領域における再建の工夫 Invited

    林 利彦

    第41回 東海頭頸部腫瘍研究会  2025.3 

    　More details

    Presentation type：Oral presentation (invited, special)  

    researchmap

  • 教育講演23（皮膚・軟部）: 皮膚悪性腫瘍の治療の考え方：診断、切除および再建について Invited

    林 利彦

    第67回日本形成外科学会総会・学術集会  2024.4 

    　More details

    Presentation type：Oral presentation (invited, special)  

    researchmap

  • ランチョンセミナー：CLTI患者に対する創傷管理―外科医が考えるレオカーナの使用目的と使いどころ― Invited

    林 利彦

    第16回日本創傷外科学会総会・学術集会  2024.7 

    　More details

    Presentation type：Public lecture, seminar, tutorial, course, or other speech  

    researchmap

  • 再建マイクロ分野指導医セミナー：下顎再建を行うための基礎知識 Invited

    林 利彦

    第33回日本形成外科学会基礎学術集会  2024.10 

    　More details

    Presentation type：Oral presentation (invited, special)  

    researchmap

▼display all

Research Projects

  • Effects of negative pressure wound therapy on the hair cycle and hair growth

    Grant number：23K09093  2023.4 - 2026.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    　 More details

    Grant amount：\4,810,000 （ Direct Cost: \3,700,000 、 Indirect Cost：\1,110,000 ）

    researchmap

  • Novel Treatment of Chronic Wounds of the Lower Extremity with Drugs Activating the Hypoxic Response System

    Grant number：20K09841  2020.4 - 2023.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Osawa Masayuki

    　 More details

    Grant amount：\4,160,000 （ Direct Cost: \3,200,000 、 Indirect Cost：\960,000 ）

    The organism expresses HIF-1α (hypoxia inducible factor-1 alpha) as an adaptive response to hypoxia. This study was initiated to examine the effects of HIF-1α modulating agents on a mouse model of hindlimb lymphedema and to develop a treatment for lymphedema, including chronic wounds. In this study, we administered roxadustat, a HIF-1α stabilizer, to a hindlimb lymphedema model and examined whether changes in hindlimb circumference, lymphatic flow, histopathology, gene expression, etc. were observed. The results suggest that roxadustat may promote lymphangiogenesis in lymphedema and may have a therapeutic effect on lymph edema.

    researchmap

  • Roles of the hypoxia response system in keloids: Normalization of local immunity and suppression of inflammation and fibrosis

    Grant number：20K09858  2020.4 - 2023.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Murao Naoki

    　 More details

    Grant amount：\4,030,000 （ Direct Cost: \3,100,000 、 Indirect Cost：\930,000 ）

    Keloid is a condition in which inflammation and fibrosis are excessively enhanced due to abnormalities in the wound healing process.It has been reported that the center of keloid tissue is in a hypoxic state.In this study, we aimed to examine how the hypoxic response of the organism has an impact on keloid pathogenesis, particularly on the immune balance by Th17 cells and regulatory T cells. As a result, histopathological evaluation showed enhanced expression of HIF-1α, a hypoxic response factor, in keloid tissues, while expression of FOXP3, a transcriptional factor of regulatory T cells, was decreased.In hypoxic cultures of keloid fibroblasts, increased mRNA expression of HIF-1α and COL I, VEGF was observed.

    researchmap

  • Potential abilities of visceral fat:circulation and immunity (hyper 2-way player)

    Grant number：19H03811  2019.4 - 2022.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Yamamoto Yuhei

    　 More details

    Grant amount：\16,510,000 （ Direct Cost: \12,700,000 、 Indirect Cost：\3,810,000 ）

    Reconstruction using various materials has been reported as a method of physiologic surgical treatment of impairment of local lymphatic system. In this study, we focused on the omentum, which is considered to play a central role immunologically among visceral fat and verified it in an experimental animal model using mice.
    We designed two models: a pedicled omentum transplantation model in which blood flow is maintained as a stemmed tissue valve, and a less invasive free omentum transplantation model, and compared and verified the contribution of each group to lymphatic reconstruction. The results suggest that both groups may promote lymphatic remodeling.

    researchmap

  • The Study on Promotion the Survival of Fat Grafts by Amnion-Derived Mesenchymal Stem Cells

    Grant number：18K09472  2018.4 - 2021.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Funayama Emi

    　 More details

    Grant amount：\4,420,000 （ Direct Cost: \3,400,000 、 Indirect Cost：\1,020,000 ）

    Mesenchymal stem cells (MSCs) have been investigated to promote the survival of fat grafts, such as using grafts with autologous stromal vascular fractions or adipose-derived MSCs. Amnion is a rich source of MSCs that is available to allogeneic transplantation. We explored the feasibility of using amnion-derived MSCs (AMSCs) to enhance fat graft survival, and suggested that AMSCs promote the survival of fat grafts and prevent fibrosis in the grafts.

    researchmap

  • Development of functional lymph node transfer

    Grant number：16H05491  2016.4 - 2019.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    YAMAMOTO Yuhei, FURUKAWA Hiroshi

    　 More details

    Grant type：Competitive

    Grant amount：\17,290,000 （ Direct Cost: \13,300,000 、 Indirect Cost：\3,990,000 ）

    Vascularized lymph node transfer is gaining popularity in the treatment of lymphedema. However, it is unclear whether vascularization of transferred lymph nodes contributes to functional improvement. This is the first experimental study to compare changes in the quantitative histology of transferred lymph nodes with or without vascularization in a mouse model of vascularized lymph node transfer. We found that vascularized lymph node transfer preserved more functional high endothelial venules within the transferred lymph node than did nonvascularized lymph node transfer.

    researchmap

  • The surgical lymphatic regeneration for improving the prognosis of melanoma

    Grant number：15H05001  2015.4 - 2018.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    FURUKAWA Hiroshi

    　 More details

    Grant type：Competitive

    Grant amount：\16,510,000 （ Direct Cost: \12,700,000 、 Indirect Cost：\3,810,000 ）

    Recently, as a relatively new physiologic surgical treatment of impairment of local lymphatic system, lymph node transplantation was introduced and applied. However, the reports supporting the utility of the lymph node transplantation are limited.
    Here, the authors demonstrated that a transplanted LN served as a tumor-draining LN and exerted an immune-mediated antitumor effect. Following local tumor control by surgical resection, an additional lymph node transplant might be practical for preventing lymphedema and reduced immunity.

    researchmap

  • Investigation of the anti inflammatory and antifibrotic function of regulatory T cells to establish the immune cell therapy in keloid

    Grant number：26293379  2014.4 - 2017.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    MURAO Naoki, SEINO Kenichiro

    　 More details

    Grant type：Competitive

    Grant amount：\16,120,000 （ Direct Cost: \12,400,000 、 Indirect Cost：\3,720,000 ）

    Keloid is an inflammatory and fibrotic disease. CD4+ T cells have been shown to play an important role in regulating inflammation and fibrosis. CD4+ T cells, especially regulatory T cells, suppress the inflammatory response and the expression of inflammatory cytokines via secreting an anti inflammatory cytokine IL-10. Nevertheless, little is known about the role of CD4+ T cells in the pathogenesis of keloid. We therefore investigated the interaction between CD4+ T cells and keloid fibroblasts using a coculture system. Our data suggested that IL-10 secreted from CD4+ T cells attenuate IL-6 production in keloid fibroblasts. Strategies to activate CD4+ T cells secreting IL-10 in keloids might represent a novel approach for the treatment of keloids.

    researchmap

  • Elucidation of the pathology of lymphedema and search for effective lymphangiogenesis

    Grant number：26462722  2014.4 - 2017.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Oyama Akihiko

    　 More details

    Grant type：Competitive

    Grant amount：\4,940,000 （ Direct Cost: \3,800,000 、 Indirect Cost：\1,140,000 ）

    As a treatment for lymphedema, conservative treatment and surgical treatment including lymphaticovenous anastomosis are performed, but treatment is often difficult. Therefore, effective treatment for lymphedema including new lymphatic regeneration is desired. It has been reported that VEGF-C which is one of vascular endothelial cell growth factors induces lymphatic regeneration in lymphedema tissues by stimulating lymphatic endothelium and promoting migration of lymphatic endothelial cells . In this study, we aimed to develop efficient treatment of lymphedema, and aimed to analyze the role played by VEGF-C in lymphedema tissue and factors related to the regulation of expression of VEGF-C in edematous tissue. It was demonstrated that the expression of inflammatory cells such as macrophages and hypoxia response factors such as HIF-1 alpha were increased in the lymphedema.

    researchmap

  • Neurotization through the venous network in muscle : intravenous migration of Schwann cells.

    Grant number：26670767  2014.4 - 2016.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Exploratory Research

    FURUKAWA Hiroshi, YAMAMOTO Yuhei, OYAMA Akihiko, HAYASHI Toshihiko, MURAO Naoki, SHICHINOHE Ryuji, ONO Kentaro

    　 More details

    Grant type：Competitive

    Grant amount：\3,640,000 （ Direct Cost: \2,800,000 、 Indirect Cost：\840,000 ）

    This work aimed to validate whether axonal regeneration would be possible through the venous network in the muscle. At first, we planned to use the latissimus dorsi muscle dominated by thoracodorsal nerve and vein, but we changed experimental animal model because of surgical difficulty. Eventually, we used saphenous nerve and femoral vein at inside of the thigh. The saphenous nerve was cut and inserted into the femoral vein, and two months later, we removed specimen compounded of nerve and vein. The specimen was stained with NF-H and CD34 by immunostaining procedure and observed to ascertain that axonal regeneration occurred in the vein. Unfortunately, we couldn’t identify the regeneration of axons. This study indicated that the distal condition which was the target of axonal elongation was of the same importance as scaffold of axonal regeneration.

    researchmap

  • Elucidating the collapse of immune system against malignant melanoma

    Grant number：25293361  2013.4 - 2016.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    YAMAMOTO YUHEI, FURUKAWA HIROSHI, OYAMA AKIHIKO, HAYASHI TOSHIHIKO, FUNAYAMA EMI, MURAO NAOKI, SEINO KENICHIRO

    　 More details

    Grant type：Competitive

    Grant amount：\17,680,000 （ Direct Cost: \13,600,000 、 Indirect Cost：\4,080,000 ）

    This study aimed to establish a consistent mouse hindlimb lymphedema model for further investigation of the mechanism and treatment of lymphedema. Using this modified mouse model, we analyzed lymphatic function, histological changes, and the expression of lymphangiogenic factors including vascular endothelial growth factor C at various time points. In addition, we reproduced melanoma in-transit metastasis in this model by implanting melanoma cells into the footpad of mice with lymphedema. Mice with in-transit metastasis were more likely to develop lung metastases than control mice. Primary tumor growth was augmented in lymphedema mice compared with control mice. These findings suggest that lymphatic dysfunction attenuates tumor immunity in malignant melanoma.

    researchmap

  • Effect of immunosuppressive agents on the interaction between keloid fibroblasts and CD4+ T cells in a coculture model

    Grant number：25670745  2013.4 - 2015.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Exploratory Research

    YAMAMOTO Yuhei, FURUKAWA Hiroshi, OYAMA Akihiko, FUNAYAMA Emi, HAYASHI Toshihiko, MURAO Naoki

    　 More details

    Grant type：Competitive

    Grant amount：\3,640,000 （ Direct Cost: \2,800,000 、 Indirect Cost：\840,000 ）

    Keloid is an inflammatory and fibrotic disease. To modulate inflammation is an important approach for the treatment of keloids. We investigated the effect of immunosuppressive agents on the interaction between keloid fibroblasts and CD4+ T cells in a coculture system. Our results suggest that the agents may affect keloid formation by modulating inflammation and directly affecting keloid fibroblasts.

    researchmap

  • The efficiency of side-to-side neurorrhaphy : the condition of donor nerve effects neural recovery.

    Grant number：25670746  2013.4 - 2015.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Exploratory Research

    OSAWA Masayuki, YAMAMOTO Yuhei, FURUKAWA Hiroshi, OYAMA Akihiko, FUNAYAMA Emi, HAYASHI Toshihiko, MURAO Naoki

    　 More details

    Grant type：Competitive

    Grant amount：\3,640,000 （ Direct Cost: \2,800,000 、 Indirect Cost：\840,000 ）

    This study demonstrated that the effect of neural reconstruction in rat models. In control group (group A), buccal branch was compressed by a ligature clip at peripheral to bifurcation of mandibular brunch and mandibular brunch was cut and ligated. In groups B, C and D, the nerve reconstruction was made in a different manner. The method of neurorrhaphy were ‘end-to-side’(group B), ‘side-to-side (large window)’(group C) and ‘side-to-side (small window)’(group D) technique. Facial palsy score was assessed every week. We measured the count of neural cells at the facial nucleus and axons at the distal point of neurorrhaphy.
    The result showed that group B was equal to group C and group D was inferior to B and C, and group A was worst score in all groups.

    researchmap

  • Imaging of lymph flow in mouse model using in vivo imaging system

    Grant number：24592704  2012.4 - 2015.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    HORIUCHI Katsumi, YAMAMOTO Yuhei, FURUKAWA Hiroshi, OYAMA Akihiko, FUNAYAMA Emi, HAYASHI Toshihiko, OSAWA Masayuki, SEKIDO Mitsuru

    　 More details

    Grant type：Competitive

    Grant amount：\5,460,000 （ Direct Cost: \4,200,000 、 Indirect Cost：\1,260,000 ）

    We analyzed the mechanism of the improvement of lymphedema using mouse hind limb model, with fluorescence lymphatic imaging using indocyanine green and in vivo imaging system as a fluorescence detector. To evaluate the improvement of lymphedema paw volume was measured using a water displacement plethysmometer,
    We found a constant correlation between a degree of paw edema improvement and the reduction of the intensity of fluorescence.

    researchmap

  • Effects of estrogen and selective estrogen receptor modulators on normal and keloid fibroblasts

    Grant number：24659777  2012.4 - 2014.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Exploratory Research

    FURUKAWA Hiroshi, YAMAMOTO Yuhei, OYAMA Akihiko, FUNAYAMA Emi, HAYASHI Toshiyuki, HORIUCHI Katsumi, SAITO Noriko

    　 More details

    Grant type：Competitive

    Grant amount：\3,640,000 （ Direct Cost: \2,800,000 、 Indirect Cost：\840,000 ）

    Selective estrogen receptor modulators (SERMs) bind to estrogen receptors acting as an agonist or an antagonist depending on the target tissue. First, we detected the expression of estrogen receptors in keloid fibroblasts. Second, we investigated the effects of SERMs on keloid fibroblasts. The effect is different depending on the concentration of SERMs. Some SERMs are suggested to inhibit cell proliferation of keloid fibroblasts.

    researchmap

  • Lymph node targeting by human interferon-ß with hyaluronic acid based on metal coordination

    Grant number：23390406  2011.4 - 2014.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    AKIRA Saito, YAMAMOTO Yuhei, FURUKAWA Hiroshi, OYAMA Akihiko, FUNAYAMA Emi, HAYASHI Toshihiko, TABATA Yasuhiko

    　 More details

    Grant type：Competitive

    Grant amount：\18,720,000 （ Direct Cost: \14,400,000 、 Indirect Cost：\4,320,000 ）

    The purpose of this study was to reduce the side effects and the pain caused by frequent injections of IFN-beta for melanoma while specifically targeting the lymph nodes by taking advantage of metal coordination to bind IFN-beta to hyaluronic acid. Sustained release of IFN-beta by conjugation with HA prolongs lymphatic retention. IFN-beta-hyaluronic acid conjugates can be given as an adjuvant therapy post-surgery to reduce the risk of recurrence and eradicate melanoma residuals, such as micrometastases. In addition, due to the sustained release characteristics of the conjugate, weekly injections for melanoma could replace conventional daily injections, thereby reducing pain as well as healthcare costs.

    researchmap

  • Controlled release of granulocyte colony-stimulating factor (G-CSF) enhances osteoconductive and biodegradable properties of beta-tricalcium phosphate (beta-TCP) in a rat calvarial defect model

    Grant number：23659826  2011.4 - 2013

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Exploratory Research

    OYAMA Akihiko, YAMAMOTO Yuhei, FURUKAWA Hiroshi, FUNAYAMA Emi, HAYASHI Toshikhiko, SAITO Akira, TABATA Yasuhiko

    　 More details

    Grant type：Competitive

    Grant amount：\3,640,000 （ Direct Cost: \2,800,000 、 Indirect Cost：\840,000 ）

    A total of 27 calvarial defects were randomly divided into nine treatment groups. One set of defects was filled with a beta-TCP disc containing normal saline alone (group-A, control) or 1 (group-B), 5 (group-C), or 20 ug of G-CSF saline solution (group-D). Another set of defects was filled with a beta-TCP disc with an overlaid gelatin hydrogel sheet incorporating normal saline alone (group-E), or 1 (group-F), 5 (group-G), or 20 ug of G-CSF solution (group-H). The last set of defects was left untreated (group-I). Histologic and histomorphometric analyses were performed at eight weeks postoperatively.
    In groups F and G, values of newly formed bone were significantly higher compared to group A. The percentage of remaining beta-TCP in group G was significantly lower compared to group A.

    researchmap

  • Does HGF act as a inhibitor of TGF-β mediated keloid formation?

    Grant number：23659825  2011.4 - 2012

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Exploratory Research

    YAMAMOTO Yuhei, FURUKAWA Hiroshi, OYAMA Akihiko, FUNAYAMA Emi, HAYASHI Toshihiko, SAITO Akira

    　 More details

    Grant type：Competitive

    Grant amount：\3,640,000 （ Direct Cost: \2,800,000 、 Indirect Cost：\840,000 ）

    HGF (hepatocyte growth factor) and TGF-β(transforming growth factor-β) often act antagonistically each other. For example, TGF-β accelerates liver fibrosis, whereas HGF prevents its progression. In our study, HGF suppressed type I collagen mRNA expression in keloid fibroblasts. HGF is suggested to repress TGF-β signal transduction pathway.

    researchmap

  • A New Perspective Of Therapies For Keloids: Application Of An Antifibrotic Medicine

    Grant number：23592637  2011 - 2013

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    HAYASHI TOSHIHIKO, YAMAMOTO Yuhei, FURUKAWA Hiroshi, OYAMA Akihiko, FUNAYAMA Emi, SAITO Akira, MURAO Naoki

    　 More details

    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\5,070,000 （ Direct Cost: \3,900,000 、 Indirect Cost：\1,170,000 ）

    Pirfenidone is a novel anti-fibrotic agent used in the treatment of idiopathic pulmonary fibrosis. Keloid is a cutaneous fibrotic disease characterized by fibroblast overproliferation and fibrogenesis such as the abnormally high production of alpha smooth muscle actin and collagen in keloid-derived fibroblasts. The effects of pirfenidone on cell proliferation, type I collagen production, and alpha-smooth muscle actin expression in keloid-derived fibroblasts were investigated in this study.
    Results showed that pirfenidone significantly inhibited cell proliferation, type I collagen production, and alpha-smooth muscle actin expression in keloid-derived fibroblasts. Our study highlights the potential use of pirfenidone in the treatment of keloids.

    researchmap

  • Clarifying the metastatic mechanisms of melanoma by imaging techniques

    Grant number：22390330  2010 - 2012

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    FURUKAWA Hiroshi, YAMAMOTO Yuhei, OYAMA Akihiko, FUNAYAMA Emi, HAYASHI Toshihiko, SAITO Akira, OZAKI Michitaka, TSUTSUMIDA Arata, KUGE Yuji, OASHI Kohei

    　 More details

    Authorship：Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type：Competitive

    Grant amount：\19,110,000 （ Direct Cost: \14,700,000 、 Indirect Cost：\4,410,000 ）

    We reproduced melanoma in-transit metastasis (ITM) in a mouse hind limb by transplanting melanoma cells into the footpad of a mouse with lymphedema (LE). The tumor cells at the ITM site were highly proliferative, and mice with ITMs were more likely than control mice to develop distant lymph node and lung metastases. Peritumoral lymphatic vessels and tumor-associated blood vessels were increased in the primary tumor site of the LE mice.

    researchmap

  • Dynamic change of Myogenin in denervated rat mimetic muscle: Does the neural repair repress its expression ?

    Grant number：22390331  2010 - 2012

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    YAMAMOTO Yuhei, SEKIDOU Mitsuru, HATOU Naoto, FURUKAWA Hiroshi, OYAMA Akihiro

    　 More details

    Grant amount：\18,980,000 （ Direct Cost: \14,600,000 、 Indirect Cost：\4,380,000 ）

    Myogenin expression in facial mimetic muscles would be accumulated by denervation rapidly, and repressed by nerve repair. Myog expression level of mimetic muscle, just after nerve repair, will help surgeon to predict thepost-operative prognosis for facial palsy.

    researchmap

  • The role of circulating fibrocytes in keloid diathesis.

    Grant number：22591988  2010 - 2012

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    FUNAYAMA Emi, YAMAMOTO Yuhei, OYAMA Akihiko, FURUKAWA Hiroshi, HAYASHI Toshihiko

    　 More details

    Authorship：Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type：Competitive

    Grant amount：\4,420,000 （ Direct Cost: \3,400,000 、 Indirect Cost：\1,020,000 ）

    Identification of chemokine (CXCL12) in human keloid tissue using immunohistochemistry(2) Development of a mouse dermal inflammation model using PMA(3) Isolation of human fibrocyte and transfer of human fibrocytes to mice

    researchmap

  • Can we detect the invasive keloid fibroblasts for the effective treatment?

    Grant number：20390454  2008 - 2010

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    HAYASHI Toshihiko, YAMAMOTO Yuhei, FURUKAWA Hiroshi, OYAMA Akihiko, FUNAYAMA Emi, SEKIDO Mitsuru, TSUTSUMIDA Arata, SAITO Akira

    　 More details

    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\19,630,000 （ Direct Cost: \15,100,000 、 Indirect Cost：\4,530,000 ）

    In a keloid lesion, T lymphocytes are found around activated and invasive keloid fibroblasts whose levels of type 1 collagen production, transforming growth factor-beta expression and α-SMA expression are very high. So we co-cultured keloid fibroblasts with T lymphocytes to establish the keloid in vitro model. But the levels of type 1 collagen and transforming growth factor-beta of the keloid fibroblasts co-cultured with T lymphocytes tended to rather decrease. Some subset of T lymphocytes might suppress keloid fibroblasts.

    researchmap

  • The influence of interactions between normal lymphatic endothelial cells and melanoma cells on cell migration

    Grant number：20390455  2008 - 2010

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    OYAMA Akihiko, YAMAMOTO Yuhei, FURUKAWA Hiroshi, FUNAYAMA Emi, HAYASHI Toshihiko, SAITO Akira

    　 More details

    Authorship：Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type：Competitive

    Grant amount：\14,560,000 （ Direct Cost: \11,200,000 、 Indirect Cost：\3,360,000 ）

    Laminin-421 secreted by LEC possibly facilitates lymphatic metastasis through the induction of chemotaxis of melanoma cells.

    researchmap

  • New lymphatic imaging with indocyanine green (ICG) dye labeled hyaluronic acid derivative

    Grant number：19390450  2007 - 2009

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    FURUKAWA Hiroshi, YAMAMOTO Yuhei, OYAMA Akihiko, FUNAYAMA Emi, HAYASHI Toshihiko, TABATA Yasuhiko

    　 More details

    Authorship：Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type：Competitive

    Grant amount：\15,470,000 （ Direct Cost: \11,900,000 、 Indirect Cost：\3,570,000 ）

    In this study, we succeeded in invention of new lymphatic imaging complex, consists of hyaluronicacid derivative labeled by indocyanine green (ICG) dye, which is clinically used in neae-infraredbioimaging, such as sentinel lymph node biopsy.Investigations into physical characteristics and in vivo kinetics of this complex have revealed that ICG fluorescence was enhanced and sustained enough for clinically use due to formation of the complex, and it is likely that the complex has more tendency to be transported to lymphatics.

    researchmap

  • 新しいケロイド治療薬としてのcAMP製剤の可能性

    Grant number：17659557  2005 - 2006

    日本学術振興会  科学研究費助成事業  萌芽研究

    山本 有平, 佐々木 了, 小山 明彦, 古川 洋志, 林 利彦, 堤田 新

    　 More details

    Authorship：Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type：Competitive

    Grant amount：\3,400,000 （ Direct Cost: \3,400,000 ）

    ブクラデシンナトリウム(DBcAMP)は細胞内に移行し脱アシル化後cAMPに変換される。cAMPの上昇はcollagenの産生の抑制を招くことが明らかになっている。このcAMPのコラーゲン産生の抑制効果を利用して、cAMP製剤(DBcAMP)が、ケロイド線維芽細胞のコラーゲンの産生を抑制すれば、新たなケロイド治療の開発につながると考え実験を計画した。そこでわれわれは、まず一般的なcAMP activatorであるForskolinを正常線維芽細胞とケロイド線維芽細胞に投与して細胞内のcAMP濃度を強制的に上昇させた。結果、正常線維芽細胞だけではなくケロイド線維芽細胞も同様にコラーゲン産生が抑制されることを確認した。つぎに、Forskolinのかわりに実際に臨床応用されているDBcAMPを用いてケロイド由来線維芽細胞のコラーゲン産生の抑制効果を検討した。結果、DBcAMPを添加した場合、比較的高濃度で正常線維芽細胞とケロイド由来線維芽細胞ともコラーゲン産生が抑制されることを確認した。すなわち、細胞外のDBcAMP投与によって細胞内cAMPが上昇して線維芽細胞のコラーゲン産生が抑制されると考えた。また、cAMPとProteinKinaseA(PKA)の関連については過去に報告があり、本研究においても細胞内cAMPの上昇からコラーゲン産生の抑制に至る経路においてPKAが関与している...

    researchmap

▼display all

Social Activities

  • 旭川市民公開講座：こんな時には形成外科へ ー傷跡が気になる、瞼が下がって見えずらい、乳房再建の話が聞きたい・・などー

    Role(s)： Lecturer

    2024.11

    　More details

    Type：Lecture

    researchmap

  • 道北小児科懇話会：小児科領域の形成外科診療

    Role(s)： Lecturer

    2023.12

    　More details

    小児科領域の形成外科診療

    researchmap

  • 旭川歯科医師会学術講演会：歯科と形成外科との関わりーチーム医療に必須の要件とは？ー

    Role(s)： Lecturer

    2023.10

    　More details

    Type：Lecture

    歯科と形成外科との関わりーチーム医療に必須の要件とは？ー

    researchmap

  • 旭川市民講座（WEB配信） 講演

    Role(s)： Lecturer

    2023.2

    　More details

    Type：Lecture

    乳房再建を考えている患者さんへー わかりやすい基礎知識 ー

    researchmap

  • 北部檜山医師会学術講演会 講演

    Role(s)： Lecturer

    2022.6

    　More details

Academic Activities

  • 第6回WOUND BED PREPARATION研究会 座長

    2024.11

    　More details

    Type：Academic society, research group, etc. 

    researchmap

  • 第48回日本頭頸部癌学会：再建ー下顎（シュミレーション） 座長

    2024.6

    　More details

    Type：Academic society, research group, etc. 

    researchmap

  • 第 31 回 日本熱傷学会 北海道地方会 協賛セミナー 座長

    2024.2

    　More details

    テーマ：手・足部熱傷に対してのNexoBridを併用したRECELL治療戦略

    researchmap

  • 第50回日本マイクロサージャリー学会学術集会 座長

    2023.12

    　More details

  • 第2回HOKKAIDO LM セミナー 司会

    2023.11

    　More details

  • 第105回北日本形成外科学会北海道地方会 会長

    2023.10

    　More details

  • 第5回WOUND BED PREPARATION研究会 座長

    2023.7

    　More details

  • 第49回日本マイクロサージャリー学会学術集会 座長

    2022.12

    　More details

  • Hokkaido LM Expert Seminar 司会

    2022.11

    　More details

  • 第4回WOUND BED PREPARATION研究会 座長

    2022.8

    　More details

  • 第65回日本形成外科学会総会・学術大会 座長

    2022.4

    　More details

  • The 2nd World Congress of Global Scar Society with Scar Academy and Japan Scar Workshop 座長

    2021.12

    　More details

  • 第102回北日本形成外科学会北海道地方会 座長

    2021.12

    　More details

  • 第48回日本マイクロサージャリー学会学術集会 座長

    2021.12

    　More details

  • 創傷治癒WEB交流会：創傷治癒連携セミナー（科研製薬株式会社） 座長

    2021.10

    　More details

  • 第3回WOUND BED PREPARATION研究会 座長

    2021.10

    　More details

  • 第37回日本皮膚悪性腫瘍学会学術大会 座長

    2021.7

    　More details

  • 瘢痕・ケロイド治療研究会 理事 International contribution

    　More details

  • 日本形成外科学会 評議員

    　More details

  • 日本皮膚悪性腫瘍学会 評議員 International contribution

    　More details

  • 日本マイクロサージャリー学会 評議員

    　More details

  • 北海道歯学会 評議員 International contribution

    　More details

  • 北日本形成外科学会 評議員 International contribution

    　More details

  • 日本形成外科手術手技学会 理事 International contribution

    　More details

  • 日本創傷外科学会 評議員 International contribution

    　More details

  • 北海道静脈フォーラム 評議員 International contribution

    　More details

  • 北海道医学会 評議員 International contribution

    　More details

  • 日本頭蓋顎顔面外科学会 評議員 International contribution

    　More details

▼display all