Updated on 2026/03/05

写真a

 
HASHIOKA Sadayuki
 
Organization
School of Medicine Medical Course Clinical Medicine Psychiatry
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Degree

  • 博士(医学) ( 2006.3   九州大学 )

  • 博士(医学) ( 2006.3 )

Research Interests

  • グリア細胞

  • 薬剤抵抗性精神疾患

  • Neuroinflammation

  • Electroconvulsive treatment

  • Microglia

  • Astrocytes

  • Neurodegenerative disorders

  • Neuroinflammation

Research Areas

  • Life Science / Psychiatry

  • Life Science / Pathobiochemistry

  • Life Science / Psychiatry

Education

  • Kyushu University   Graduate School, Division of Medical Sciences

    - 2006.3

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    Country: Japan

  • Miyazaki Medical College   Faculty of Medicine

    - 1998.3

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    Country: Japan

Research History

  • Asahikawa Medical College   Professor

    2022.4

  • 旭川医科大学精神医学講座

    2022.4

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  • Shimane University   Associate Professor

    2020.10 - 2022.3

  • 島根大学医学部精神医学講座

    2012.10 - 2022.3

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  • Shimane University   Lecturer

    2012.10 - 2020.9

  • Kyushu University   Part-time researcher for university or other academic organization

    2011.10 - 2012.9

  • University of British Columbia   Researcher

    2006.8 - 2011.9

  • University of British Columbia

    2006.8 - 2011.9

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    Country:Canada

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  • 九州大学大学院医学系学府精神病態医学

    2003.4 - 2006.3

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Professional Memberships

  • 日本精神神経学会

    2009.4

  • 日本生物学的精神医学会

    2002.4

  • 日本認知症学会

    2017.3

  • 日本神経化学会

    2022.6

  • Society for Neuroscience

    2004.4

  • 日本神経精神医学会

    2022.8

  • 日本神経精神医学会

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  • 日本神経化学会

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  • International Early Psychosis Association

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  • World Federation of Societies of Biological Psychiatry

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  • Society for Neuroscience

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  • 日本認知症学会

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  • 日本生物学的精神医学会

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  • 日本精神神経学会

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Committee Memberships

  • 日本精神神経学会   代議員  

    2025.4   

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    Committee type:Academic society

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  • 日本神経精神医学会   評議員  

    2023.12   

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    Committee type:Academic society

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  • 日本神経化学会   評議員  

    2023.4   

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  • 日本認知症学会   代議員  

    2020.11   

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  • 日本生物学的精神医学会   編集委員  

    2018.6   

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  • 日本生物学的精神医学会   評議員  

    2013.4   

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Studying abroad experiences

  • 2006.8 - 2011.9   University of British Columbia  

Papers

  • Glia as a New Target for Therapeutic Actions of Electroconvulsive Therapy. International journal

    Sadayuki Hashioka

    CNS & neurological disorders drug targets   24 ( 1 )   2 - 6   2025

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    Language:English   Publishing type:Research paper (scientific journal)  

    Although electroconvulsive therapy (ECT) has immediate and profound effects on severe psychiatric disorders compared to pharmacotherapy, the mechanisms underlying its therapeutic effects remain elusive. Increasing evidence indicates that glial activation is a common pathogenetic factor in both major depression and schizophrenia, raising the question of whether ECT can inhibit glial activation. This article summarizes the findings from both clinical and experimental studies addressing this key question. Based on the findings, it is proposed that the suppression of glial activation associated with neuroinflammation may be involved in the mechanism by which ECT restores brain homeostasis and exerts its therapeutic effects.

    DOI: 10.2174/0118715273319405240707164638

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  • ラットモデルを用いた電気けいれん療法とグリアの研究 Invited

    橋岡禎征

    精神科   43   401 - 405   2023.10

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Video polysomnographic analysis of elevated EMG activity and rapid eye movements before abnormal behaviors in REM sleep behavior disorder.

    Mondo Yoshizawa, Yoshiyuki Tamura, Asami Yasuda-Ohata, Shinsuke Yoshihara, Hideki Takasaki, Sadayuki Hashioka

    Sleep and biological rhythms   21 ( 4 )   455 - 460   2023.10

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    The pathogenesis of rapid eye movement (REM) sleep behavior disorder (RBD) is unclear. According to the cortical hypothesis, severe RBD episode (RBDE) occurs when spinal motoneurons are less inhibited and cortical and limbic systems are more active. We made this study to prove the hypothesis for the development of RBDE using video-polysomnography (VPSG). VPSG records of 35 patients with RBD were analyzed. According to severity, RBDEs were classified into three motor events (MEs): ME 1; small movements or jerks, ME 2; proximal movements including violent behavior, and ME 3; axial movements including bed falls. For each ME, we measured the number of MEs preceded or not preceded by both REM sleep without atonia (RWA) and REMs during the 10-s-period immediately before ME onset. In severe RBDE (ME 3), the number of MEs preceded by both RWA and REMs was significantly higher than that of MEs not preceded by both (0.8 vs. 0.2, P = 0.033). This was not the case for mild RBDE (ME 1) and moderate RBDE (ME 2). Our results suggest that both RWA and REMs are associated with the development of severe RBDE.

    DOI: 10.1007/s41105-023-00472-2

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  • Systemic administration of Porphyromonas gingivalis lipopolysaccharide induces glial activation and depressive-like behavior in rats Reviewed

    Mamunur R, Hashioka S, Azis IA, Jaya MA, Jerin SJF, Kimura-Kataoka K, Fujihara J, Inoue K, Inagaki M, Takeshita H

    Journal of Integrative Neuroscience   22   120   2023.8

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

  • Systemic Administration of Porphyromonas Gingivalis Lipopolysaccharide Induces Glial Activation and Depressive-Like Behavior in Rats. International journal

    Rahman Mamunur, Sadayuki Hashioka, Ilhamuddin A Azis, Muhammad A Jaya, Sultana J F Jerin, Kaori Kimura-Kataoka, Junko Fujihara, Ken Inoue, Masatoshi Inagaki, Haruo Takeshita

    Journal of integrative neuroscience   22 ( 5 )   120 - 120   2023.8

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    BACKGROUND: Periodontitis is one of the most common chronic inflammatory disorders in adults. Although clinical studies have suggested a causal relationship between periodontitis and major depression (MD), the biological mechanisms by which periodontitis instigates MD are unknown. We investigated whether a systemic administration of lipopolysaccharide (LPS) from Porphyromonas gingivalis (Pg), a major Gram-negative pathogen of periodontitis, causes depressive-like behavior and glial activation in the hippocampus and the prefrontal cortex (PFC), which are MD-related brain regions. MATERIALS AND METHODS: Eight-week-old male Sprague Dawley rats were randomly divided into a behavioral test group and an immunohistochemistry group. The rats in each group were further assigned to the sham injection (saline) and Porphyromonas gingivalis-lipopolysaccharide (Pg-LPS) injection protocols. The rats received an intraperitoneal injection of saline or Pg-LPS with gradually increasing doses (day 1: 0.5, day 2: 0.5, day 3: 0.75, day 4: 0.75, day 5: 1.0, day 6: 1.0, and day 7: 1.0 mg/kg of body weight) for seven consecutive days. After the systemic administration, the behavior test group underwent the forced swimming test (FST) and Y-maze test. For the immunohistochemistry group, we quantified the immunoreactivity for microglial Iba-1 (ionized calcium-binding adapter molecule 1) and astrocytic glial fibrillary acidic protein (GFAP) in the hippocampus (dentate gyrus [DG], cornu ammonis [CA1 and CA3]) and PFC (prelimbic [PrL] and the infralimbic [IL]) areas. RESULTS: The FST immobility time in the Pg-LPS group was significantly longer than that in the sham group. In the Y-maze test, a significant decline in spontaneous alternation behavior was observed in the Pg-LPS group compared to the sham group. The peripheral administration of Pg-LPS significantly increased the immunoreactivity for Iba-1 in the CA3 and PrL. Pg-LPS injection significantly increased the immunoreactivity for GFAP in the DG, CA1, and CA3. CONCLUSIONS: The major result of this study is that a repeated systemic administration of Pg-LPS caused depressive-like behavior and both microglial and astrocytic activation in rats. This finding may comprise biological evidence of a causal relationship between periodontitis and MD.

    DOI: 10.31083/j.jin2205120

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  • Video polysomnographic analysis of elevated EMG activity and rapid eye movements before abnormal behaviors in REM sleep behavior disorder. Reviewed

    Yoshizawa M, Tamura Y, Yasuda A, Yoshihara S, Takasaki H, Hashioka S

    Sleep and Biological Rhythms   21   455 - 460   2023.7

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

  • 遅発性ジストニアと強迫性障害の合併例に修正型電気けいれん療法が奏功した1例

    三原 靖葉, 大朏 孝治, 林 真一郎, 林 茉衣, 正岡 浩, 山下 智子, 長濱 道治, 林田 麻衣子, 橋岡 禎征, 稲垣 正俊

    精神神経学雑誌   125 ( 4 )   321 - 321   2023.4

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  • てんかん精神病と統合失調症との鑑別に苦慮した1例

    林 真一郎, 長濱 道治, 大朏 孝治, 林 茉衣, 正岡 浩, 三原 靖葉, 三浦 章子, 山下 智子, 林田 麻衣子, 橋岡 禎征, 稲垣 正俊

    精神神経学雑誌   125 ( 4 )   327 - 327   2023.4

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  • 身体愁訴に対して抑肝散加陳皮半夏が有用と思われたアルツハイマー型認知症の1例

    長濱 道治, 河野 公範, 林 真一郎, 三原 靖葉, 林 茉衣, 正岡 浩, 小池 昌弘, 三浦 章子, 山下 智子, 大朏 孝治, 林田 麻衣子, 岡崎 四方, 和氣 玲, 橋岡 禎征, 稲垣 正俊

    精神神経学雑誌   125 ( 4 )   324 - 324   2023.4

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  • Gunn ratにおける認知機能障害と活性化したグリア細胞に対する人参栄養湯の効果(The Effects of Ninjin' yoeito on Cognitive Dysfunction And Activated Glial Cells in the Gunn Rats)

    ジャヤ・アリム, 林田 麻衣子, 土江 景子, 三浦 章子, 長濱 道治, 大朏 孝治, 橋岡 禎征, 和氣 玲, 大西 新, 宮岡 剛, タンラ・アンディ, 稲垣 正俊

    精神神経学雑誌   125 ( 4 )   322 - 322   2023.4

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  • Electroconvulsive treatment ameliorates lipopolysaccharide-induced depressive like behaviour in rats Reviewed

    1. Jerin SJ, Hashioka S, Kimura-Kataoka K, Fujihara J, Mamunur R, Ao G, Inagaki M, Haruo Takeshita H

    Shimane Journal of Medical Science   2023.3

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

  • 電気けいれん療法とグリア研究の融合点 Invited

    橋岡禎征

    精神科治療学   2022.11

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Glia-driven neuroinflammation and systemic inflammation in Alzheimer’s disease Invited Reviewed

    Hashioka S, Wu Z, Klegeris A

    Current Neuropharmacology   2022.7

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  • Effect of Ninjin’yoeito on lipopolysaccharide-induced depressive-like behavior and glial activation in the hippocampus Reviewed

    Jaya MA, Hayashida M, Tsuchie K, Jerin SJ, Mamunur R, Miura S, Nagahama M, Otsuki K, Hashioka S, Wake R, Miyaoka T, Tanra AJ, Horiguchi J, Inagaki M

    Shimane Journal of Medical Science   2022.6

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  • Improvement in both severe obsessive–compulsive disorder and refractory tardive dystonia following electroconvulsive therapy: A case report Reviewed

    Yasuha Mihara, Koji Otsuki, Mai Hayashi, Satoko Yamashita, Michiharu Nagahama, Maiko Hayashida, Rei Wake, Sadayuki Hashioka, Satoshi Abe, Masatoshi Inagaki

    Psychiatry and Clinical Neurosciences Reports   2022.6

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    DOI: 10.1002/pcn5.15

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  • Improvement in both severe obsessive compulsive disorder and refractory tardive dystonia following electroconvulsive therapy Reviewed

    Mihara Y, Otsuki K, Hayashi M, Yamashita S, Nagahama M, Hayashida M, Wake R, Hashioka S, Abe S, Inagaki M

    PCN Reports   2022.5

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  • Contribution of "genuine microglia" to Alzheimer's disease pathology Invited Reviewed

    Hashioka S, Inoue K, Otsuki K, Hayashida M, Wake R, Kawano N, Takeshita H, Inagaki M

    Frontiers in Aging Neuroscience   2022.4

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  • 幻覚妄想に対してパリペリドン徐放錠から特効性注射剤への切り替えが著効した治療抵抗性統合失調症の一例

    佐藤 皓平, 大朏 孝治, 林 真一郎, 林 茉衣, 正岡 浩, 三原 靖葉, 三浦 章子, 山下 智子, 長濱 道治, 林田 麻衣子, 橋岡 禎征, 稲垣 正俊

    精神神経学雑誌   124 ( 4付録 )   S - 521   2022.4

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  • 良好な転帰を得た発達障害を背景とした身体症状の1例

    正岡 浩, 長濱 道治, 高野 由美子, 林 真一郎, 三原 靖葉, 林 茉衣, 小池 昌弘, 山下 智子, 河野 公範, 大朏 孝治, 林田 麻衣子, 岡崎 四方, 和氣 玲, 橋岡 禎征, 稲垣 正俊

    精神神経学雑誌   124 ( 4 )   271 - 271   2022.4

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  • 便秘症の悪化を契機に心気妄想を認め、自殺類行動を伴うせん妄を発症したと思われる高齢者の1例

    槻宅 雅史, 長濱 道治, 岡崎 四方, 林 真一郎, 三原 靖葉, 林 茉衣, 正岡 浩, 小池 昌弘, 山下 智子, 河野 公範, 大朏 孝治, 林田 麻衣子, 和氣 玲, 橋岡 禎征, 稲垣 正俊

    精神神経学雑誌   124 ( 4 )   271 - 271   2022.4

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  • 維持電気けいれん療法の導入により寛解維持が可能となった老年期うつ病の1例

    林 茉衣, 大朏 孝治, 佐藤 皓平, 林 真一郎, 三原 靖葉, 正岡 浩, 三浦 章子, 山下 智子, 長濱 道治, 林田 麻衣子, 橋岡 禎征, 稲垣 正俊

    精神神経学雑誌   124 ( 4 )   270 - 270   2022.4

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  • 母子関係の密着から困難さを抱えた女性の症例 風景構成法が示す空白領域について

    三成 綾, 高野 由美子, 井上 歩美, 松浦 和基, 長濱 道治, 大朏 孝治, 林田 麻衣子, 和氣 玲, 橋岡 禎征, 稲垣 正俊

    精神神経学雑誌   124 ( 4 )   269 - 269   2022.4

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  • パリペリドン特効性注射剤が著効した治療抵抗性統合失調症の1例

    佐藤 皓平, 大朏 孝治, 林 真一郎, 林 茉衣, 正岡 浩, 三原 靖葉, 三浦 章子, 山下 智子, 長濱 道治, 林田 麻衣子, 橋岡 禎征, 森崎 洋平, 稲垣 正俊

    精神神経学雑誌   124 ( 4 )   269 - 269   2022.4

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  • 島根大学医学部附属病院における精神科リエゾンチームの活動報告

    兒玉 麻衣子, 長濱 道治, 藤江 さとみ, 柳樂 真理子, 土江 唯子, 勝部 千賀子, 森川 貴志子, 曽田 重人, 井上 歩美, 松浦 和基, 三成 綾, 高野 由美子, 林 真一郎, 三原 靖葉, 林 茉衣, 正岡 浩, 小池 昌弘, 山下 智子, 河野 公範, 大朏 孝治, 林田 麻衣子, 岡崎 四方, 和氣 玲, 橋岡 禎征, 稲垣 正俊

    精神神経学雑誌   124 ( 4 )   269 - 269   2022.4

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  • 強迫性障害と遅発性ジストニアの合併例に修正型電気けいれん療法が奏効した一例

    三原 靖葉, 大朏 孝治, 和氣 玲, 林 真一郎, 林 茉衣, 正岡 浩, 山下 智子, 長濱 道治, 林田 麻衣子, 橋岡 禎征, 稲垣 正俊

    精神神経学雑誌   124 ( 4付録 )   S - 644   2022.4

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  • The use of video games, smartphones, and PCs/tablet PCs based on a survey of students' lifestyles: necessary actions Reviewed

    Inoue K, Fujita Y, Takeshita H, Hashioka S, Kamura M

    Public Health   2022.3

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  • Contribution of "Genuine Microglia" to Alzheimer's Disease Pathology. International journal

    Sadayuki Hashioka, Ken Inoue, Koji Otsuki, Maiko Hayashida, Rei Wake, Noriyuki Kawano, Haruo Takeshita, Masatoshi Inagaki

    Frontiers in aging neuroscience   14   815307 - 815307   2022

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    DOI: 10.3389/fnagi.2022.815307

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  • Diversity and regulation of astrocyte neurotoxicity in Alzheimer's disease Invited Reviewed

    Hashioka S, McLarnon JG, Klegeris A

    Current Alzheimer Research   2021.12

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  • 視力障害に伴う幻視に対して抑肝散が有用であった高齢者の1症例

    長濱 道治, 河野 公範, 林 真一郎, 三原 靖葉, 林 茉衣, 正岡 浩, 小池 昌弘, 三浦 章子, 山下 智子, 大朏 孝治, 林田 麻衣子, 岡崎 四方, 和氣 玲, 橋岡 禎征, 稲垣 正俊

    総合病院精神医学   33 ( Suppl. )   S - 183   2021.11

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    Language:Japanese   Publisher:(一社)日本総合病院精神医学会  

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  • 一過性精神病状態が先行し、側頭葉てんかんを認めたアルツハイマー型認知症の一例

    和氣 玲, 長濱 道治, 林 真一郎, 三原 靖葉, 林 茉衣, 正岡 浩, 小池 昌弘, 三浦 章子, 山下 智子, 河野 公範, 大朏 孝治, 岡崎 四方, 林田 麻衣子, 橋岡 禎征, 稲垣 正俊

    老年精神医学雑誌   32 ( 増刊I )   263 - 263   2021.9

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  • 妄想性障害と思われたアルツハイマー型認知症の1例

    長濱 道治, 河野 公範, 林 真一郎, 三原 靖葉, 林 茉衣, 正岡 浩, 小池 昌弘, 三浦 章子, 山下 智子, 大朏 孝治, 林田 麻衣子, 岡崎 四方, 和氣 玲, 橋岡 禎征, 稲垣 正俊

    老年精神医学雑誌   32 ( 増刊I )   235 - 235   2021.9

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  • 修正型電気けいれん療法がレビー小体病の精神症状および運動症状に有効であった1症例

    佐藤 皓平, 長濱 道治, 伊藤 司, 林 真一郎, 正岡 浩, 三原 靖葉, 林 茉衣, 伊豆原 宗人, 三浦 章子, 大朏 孝治, 林田 麻衣子, 橋岡 禎征, 稲垣 正俊

    精神神経学雑誌   ( 2021特別号 )   S619 - S619   2021.9

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  • ステロイドパルス療法が奏功した間歇型一酸化炭素中毒の一例

    林 茉衣, 三浦 章子, 上田 真大, 安部 哲史, 林 真一郎, 正岡 浩, 三原 靖葉, 伊藤 司, 佐藤 皓平, 伊豆原 宗人, 長濱 道治, 大朏 孝治, 林田 麻衣子, 橋岡 禎征, 稲垣 正俊

    精神神経学雑誌   ( 2021特別号 )   S581 - S581   2021.9

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  • 原発性副甲状腺機能亢進症と精神症状 摘出術により著しい精神症状が改善した一例を通して

    三原 靖葉, 大朏 孝治, 林 真一郎, 林 茉衣, 正岡 浩, 伊藤 司, 佐藤 皓平, 伊豆原 宗人, 三浦 章子, 長濱 道治, 林田 麻衣子, 橋岡 禎征, 稲垣 正俊

    精神神経学雑誌   ( 2021特別号 )   S580 - S580   2021.9

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  • 肝胆道系酵素著明高値をきたしrefeeding症候群と診断した神経性やせ症の一例

    正岡 浩, 林田 麻衣子, 林 真一郎, 林 茉衣, 三原 靖葉, 伊藤 司, 佐藤 皓平, 伊豆原 宗人, 三浦 章子, 長濱 道治, 大朏 孝治, 橋岡 禎征, 稲垣 正俊

    精神神経学雑誌   ( 2021特別号 )   S577 - S577   2021.9

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  • 右大腿骨頸部骨折の周術期に修正型電気けいれん療法を施行し、良好な転帰を得た治療抵抗性統合失調症の一例

    林 真一郎, 大朏 孝治, 林 茉衣, 正岡 浩, 三原 靖葉, 伊藤 司, 佐藤 皓平, 伊豆原 宗人, 三浦 章子, 長濱 道治, 林田 麻衣子, 橋岡 禎征, 稲垣 正俊

    精神神経学雑誌   ( 2021特別号 )   S566 - S566   2021.9

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  • Magnetic Resonance Spectroscopy in the Ventral Tegmental Area Distinguishes Responders to Suvorexant Prior to Treatment: A 4-Week Prospective Cohort Study

    Muneto Izuhara, Shoko Miura, Koji Otsuki, Michiharu Nagahama, Maiko Hayashida, Sadayuki Hashioka, Hiroya Asou, Hajime Kitagaki, Masatoshi Inagaki

    Frontiers in Psychiatry   12   2021.8

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    <bold>Background:</bold> The ventral tegmental area (VTA; a dopaminergic nucleus) plays an important role in the sleep-wake regulation system including orexin system. In addition to neuronal activity, there is increasing evidence for an important role of glial cells (i.e., astrocytes and microglia) in these systems. The present study examined the utility of magnetic resonance spectroscopy (MRS) for detecting neural and/or glial changes in the VTA to distinguish responders from non-responders before treatment with the orexin receptor antagonist suvorexant.

    <bold>Methods:</bold> A total of 50 patients were screened and 9 patients were excluded. The remaining 41 patients with insomnia who have or not a psychiatric disease who were expected to receive suvorexant treatment were included in this study. We compared MRS signals in the VTA between responders to suvorexant and non-responders before suvorexant use. Based on previous reports, suvorexant responders were defined as patients who improved ≥3 points on the Pittsburgh Sleep Quality Index after 4 weeks of suvorexant use. MRS data included choline (reflects non-specific cell membrane breakdown, including of glial cells) and N-acetylaspartate (a decrease reflects neuronal degeneration).

    <bold>Results:</bold> Among 41 examined patients, 20 patients responded to suvorexant and 21 patients did not. By MRS, the choline/creatine and phosphorylcreatine ratio in the VTA was significantly high in non-responders compared with responders (<italic>p</italic> = 0.039) before suvorexant treatment. There was no difference in the N-acetylaspartate/creatine and phosphorylcreatine ratio (<italic>p</italic> = 0.297) between the two groups.

    <bold>Conclusions:</bold> Changes in glial viability in the VTA might be used to distinguish responders to suvorexant from non-responders before starting treatment. These findings may help with more appropriate selection of patients for suvorexant treatment in clinical practice. Further, we provide novel possible evidence for a relationship between glial changes in the VTA and the orexin system, which may aid in the development of new hypnotics focusing on the VTA and/or glial cells.

    DOI: 10.3389/fpsyt.2021.714376

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  • Magnetic resonance spectroscopy in the ventral tegmental area distinguishes responders to suvorexant prior to treatment: A 4-week prospective cohort study Reviewed

    Izuhara M, Miura S, Otsuki K, Nagahama M, Hayashida M, Hashioka S, Asou H, Kitagaki H, Inagaki M

    Frontiers in Psychiatry   2021.8

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  • Urinary biopyrrins and free immunoglobin light chains are biomarker candidates for screening at-risk mental state in adolescents. International journal

    Rei Wake, Tomoko Araki, Michiyo Fukushima, Hiroyuki Matsuda, Takuji Inagaki, Maiko Hayashida, Sadayuki Hashioka, Jun Horiguchi, Masatoshi Inagaki, Tsuyoshi Miyaoka, Arata Oh-Nishi

    Early intervention in psychiatry   2021.5

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    BACKGROUND: Early diagnosis of individuals' at-risk mental state (ARMS) is important for preventing their pathogenesis or, at least, delaying onset of overt psychosis. Traditional diagnosis of ARMS subjects is mainly based on structured interviews, but future diagnosis would be carried out together with biomarkers. AIM: In this study, we report urinary biopyrrins and free immunoglobin light chains κ and λ (κFLC and λFLC) as novel diagnostic biomarker candidates for screening ARMS subjects. METHODS: Nineteen ARMS subjects and 21 age- and sex-matched healthy controls were enrolled in this study. Inclusion criteria of the ARMS subjects were based on a comprehensive assessment of Structured Interview for Prodromal Syndromes. We compared oxidative stress and immunological markers in the urine of ARMS subjects with those of healthy controls by ELISA protocol. RESULTS: Augmentation of biopyrrins and reduction of κFLC and λFLC were found in the ARMS samples, and their diagnostic performance was evaluated by receiver operating characteristic analysis, of which area under the curve was as large as 0.915 in combination. CONCLUSION: Our findings suggest that the ARMS subjects were under higher oxidative stress but lower in B cell activation, and that the combined assay of urinary biopyrrins and free immunoglobulin light chains would be useful for the early detection and screening of ARMS subjects among adolescents.

    DOI: 10.1111/eip.13154

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  • Seeking to address issues with COVID-19 vaccines in Japan and to resolve global problems with vaccination programmes Reviewed

    Inoue K, Ohira Y, Kawano N, Takeshita H, Hashioka S

    International Maritime Health   2021.5

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  • Studies Support the Use of Suvorexant for the Prevention of Delirium. International journal

    Muneto Izuhara, Hisae Kihara Izuhara, Keiko Tsuchie, Tomoko Araki, Tsukasa Ito, Kouhei Sato, Syoko Miura, Koji Otsuki, Michiharu Nagahama, Maiko Hayashida, Sadayuki Hashioka, Rei Wake, Tomohiro Kimura, Shusaku Tsumoto, Yoji Saito, Masatoshi Inagaki

    The Journal of clinical psychiatry   82 ( 3 )   2021.4

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  • Prompt improvement of difficulty with sleep initiation and waking up in the morning and daytime somnolence by combination therapy of suvorexant and ramelteon in delayed sleep-wake phase disorder Reviewed

    Izuhara M, Kawano K, Otsuki K, Hashioka S, Inagaki M

    Sleep Medicine   2021.4

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  • Studies support the use of suvorexant for the prevention of delirium Reviewed

    Izuhara M, Izuhara HK, Tsuchie K, Araki T, Ito T, Sato K, Miura S, Otsuki K, Nagahama M, Hayashida M, Hashioka S, Wake R, Kimura T, Tsumoto S, Saito Y, Inagaki M

    Journal of Clinical Psychiatry   2021.4

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  • Prompt improvement of difficulty with sleep initiation and waking up in the morning and daytime somnolence by combination therapy of suvorexant and ramelteon in delayed sleep-wake phase disorder: a case series of three patients

    Muneto Izuhara, Kiminori Kawano, Koji Otsuki, Sadayuki Hashioka, Masatoshi Inagaki

    Sleep Medicine   80   100 - 104   2021.4

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    DOI: 10.1016/j.sleep.2021.01.030

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  • Normalizing hyperactivity of the Gunn rat with bilirubin-induced neurological disorders via ketanserin. International journal

    Shoko Miura, Keiko Tsuchie, Michiyo Fukushima, Ryosuke Arauchi, Toshiko Tsumori, Koji Otsuki, Maiko Hayashida, Sadayuki Hashioka, Rei Wake, Tsuyoshi Miyaoka, Masatoshi Inagaki, Arata Oh-Nishi

    Pediatric research   91 ( 3 )   556 - 564   2021.3

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    BACKGROUND: Severe neonatal hyperbilirubinemia has been known to cause the clinical syndrome of kernicterus and a milder one the syndrome of bilirubin-induced neurologic dysfunction (BIND). BIND clinically manifests itself after the neonatal period as developmental delay, cognitive impairment, and related behavioral and psychiatric disorders. The complete picture of BIND is not clear. METHODS: The Gunn rat is a mutant strain of the Wistar rat with the BIND phenotype, and it demonstrates abnormal behavior. We investigated serotonergic dysfunction in Gunn rats by pharmacological analyses and ex vivo neurochemical analyses. RESULTS: Ketanserin, the 5-HT2AR antagonist, normalizes hyperlocomotion of Gunn rats. Both serotonin and its metabolites in the frontal cortex of Gunn rats were higher in concentrations than in control Wistar rats. The 5-HT2AR mRNA expression was downregulated without alteration of the protein abundance in the Gunn rat frontal cortex. The TPH2 protein level in the Gunn rat raphe region was significantly higher than that in the Wistar rat. CONCLUSIONS: It would be of value to be able to postulate that a therapeutic strategy for BIND disorders would be the restoration of brain regions affected by the serotonergic dysfunction to normal operation to prevent before or to normalize after onset of BIND manifestations. IMPACT: We demonstrated serotonergic dysregulation underlying hyperlocomotion in Gunn rats. This finding suggests that a therapeutic strategy for bilirubin-induced neurologic dysfunction (BIND) would be the restoration of brain regions affected by the serotonergic dysfunction to normal operation to prevent before or to normalize after the onset of the BIND manifestations. Ketanserin normalizes hyperlocomotion of Gunn rats. To our knowledge, this is the first study to demonstrate a hyperlocomotion link to serotonergic dysregulation in Gunn rats.

    DOI: 10.1038/s41390-021-01446-1

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  • Psychosis in a primary hyperparathyroidism patient with mild hypercalcemia: A case report. International journal

    Koji Otsuki, Muneto Izuhara, Shoko Miura, Satoko Yamashita, Michiharu Nagahama, Maiko Hayashida, Sadayuki Hashioka, Tsuyoshi Miyaoka, Yukie Hotta, Yasuhiko Shimizu, Masatoshi Inagaki

    Medicine   100 ( 12 )   e25248   2021.3

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    INTRODUCTION: Primary hyperparathyroidism (PHPT) is characterized by hypercalcemia and an elevated level of serum parathyroid hormone (PTH). PHPT presents with a complex set of renal, skeletal, and neuropsychological symptoms. Parathyroidectomy (PTX) is a radical treatment that is recommended for all physically symptomatic patients with PHPT. However, psychiatric symptoms are not considered as an indication for surgery. There remains an important issue from the view of perioperative management of whether PTX should be performed with the presence of uncontrolled psychiatric symptoms or deferred until severe psychiatric symptoms have been controlled. We report a case of mild hypercalcemia that caused severe psychosis in PHPT, which improved dramatically following PTX and resulted in successful postoperative management. PATIENT CONCERN: Our patient was a 68-year-old Japanese woman. She was diagnosed with PHPT, which was triggered by mild hypercalcemia. She was due to receive an operation for osteoporosis and kidney stones. She had severe psychosis, despite medication. Blood examinations revealed mild hypercalcemia (10.4 mg/dL, 8.8-10.1 mg/dL) and elevated serum levels of intact PTH (184.0 pg/mL, 10-65 pg/mL). DIAGNOSIS: She was diagnosed with severe psychosis caused by mild hypercalcemia in PHPT. INTERVENTIONS: Although she was treated with 37.5 mg quetiapine and 2 mg risperidone daily, she was excessively sedated and rejected oral treatment. Therefore, we decided to perform the operation. OUTCOMES: Immediately following surgery, serum levels of calcium, and intact PTH were normalized. Her psychotic symptoms ceased completely 5 days after surgery. CONCLUSION: We emphasize that PHPT presents with various severe psychiatric symptoms, even in mild hypercalcemia. Psychiatric symptoms may be the only salient symptoms in PHPT, and thus clinicians should suspect PHPT in patients with psychiatric symptoms and mild hypercalcemia. Furthermore, PTX is recommended for PHPT-even in the presence of severe uncontrolled psychiatric symptoms, which carries risks for postoperative management-because psychiatric symptoms are expected to improve and good postoperative management is possible.

    DOI: 10.1097/MD.0000000000025248

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  • Psychosis in a primary hyperparathyroidism patient with mild hypercalcemia Reviewed

    Otsuki K, Izuhara M, Miura S, Yamashita S, Nagahama M, Hayashida M, Hashioka S, Miyaoka T, Hotta Y, Shimizu Y, Inagaki M

    Medicine (Baltimore)   2021.3

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  • Urinary biopyrrins and free immunoglobin light chains are biomarker candidates for screening at-risk mental state in adolescents Reviewed

    Wake R, Araki T, Fukushima M, Matsuda H, Inagaki T, Hayashida M, Hashioka S, Horiguchi J, Inagaki M, Miyaoka T, Oh-Nishi A

    Early Intervention in Psychiatry   2021.3

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  • Normalizing hyperactivity of the Gunn rat with bilirubin-induced neurological disorders via ketanserin Reviewed

    Miura S, Tsuchie K, Fukushima M, Arauchi R, Tsumori T, Otsuki K, Hayashida M, Hashioka S, Wake R, Miyaoka T, Inagaki M, Oh-Nishi A

    Pediatric Research   2021.2

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  • Seeking to address issues with COVID-19 vaccines in Japan and to resolve global problems with vaccination programmes

    Ken Inoue, Yoshiyuki Ohira, Noriyuki Kawano, Haruo Takeshita, Sadayuki Hashioka

    International Maritime Health   72 ( 2 )   142 - 142   2021

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    DOI: 10.5603/IMH.2021.0024

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  • Do Alzheimer's Disease Risk Gene Products Actually Act in Microglia?

    Sadayuki Hashioka, Ken Inoue, Haruo Takeshita, Masatoshi Inagaki

    Frontiers in Aging Neuroscience   12   2020.12

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    DOI: 10.3389/fnagi.2020.589196

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  • Do Alzheimer’s disease risk gene products actually act in microglia? Reviewed

    Hashioka S, Inoue K, Takeshita H, Inagaki M

    Frontiers in Aging Neuroscience   2020.12

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  • 事例からみる認知症と自動車運転 運転中断後に生活機能が低下した躁うつ病の一例

    長濱 道治, 河野 公範, 伊藤 司, 佐藤 皓平, 伊豆原 宗人, 小池 昌弘, 金山 三紗子, 三浦 章子, 大朏 孝治, 林田 麻衣子, 岡崎 四方, 橋岡 禎征, 和氣 玲, 稲垣 正俊, 堀口 淳

    老年精神医学雑誌   31 ( 増刊II )   113 - 113   2020.12

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  • 口腔内セネストパチー、実体的意識性が先行した早発性アルツハイマー型認知症の一例

    和氣 玲, 長濱 道治, 伊豆原 宗人, 伊藤 司, 佐藤 皓平, 錦織 光, 松田 泰行, 金山 三紗子, 三浦 章子, 山下 智子, 大朏 孝治, 岡崎 四方, 林田 麻衣子, 橋岡 禎征, 稲垣 正俊

    老年精神医学雑誌   31 ( 増刊II )   195 - 195   2020.12

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  • 体感幻覚様の症状が先行したレビー小体病の1例

    長濱 道治, 河野 公範, 伊藤 司, 佐藤 皓平, 伊豆原 宗人, 小池 昌弘, 金山 三紗子, 三浦 章子, 大朏 孝治, 林田 麻衣子, 岡崎 四方, 橋岡 禎征, 和氣 玲, 稲垣 正俊, 堀口 淳

    老年精神医学雑誌   31 ( 増刊II )   159 - 159   2020.12

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  • Glia-driven neuroinflammation and systemic inflammation in Alzheimer's disease. International journal

    Sadayuki Hashioka, Zhou Wu, Andis Klegeris

    Current neuropharmacology   2020.11

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    The neuroinflammatory hypothesis of Alzheimer's disease (AD) was proposed more than 30 years ago. The involvement of the two main types of glial cells, microglia and astrocytes, in neuroinflammation was suggested early on. In this review we highlight that the exact contributions of reactive glia to AD pathogenesis remain difficult to define likely due to the heterogeneity of glia populations and alterations in their activation states through the stages of AD progression. In the case of microglia, it is becoming apparent that both beneficially and adversely activated cell populations can be identified at various stages of AD, which could be selectively targeted to either limit their damaging actions or enhance beneficial functions. In the case of astrocytes, less information is available about potential subpopulations of reactive cells; it also remains elusive whether astrocytes contribute to the neuropathology of AD by mainly gaining neurotoxic functions or losing their ability to support neurons due to astrocyte damage. We identify L-type calcium channel blocker, nimodipine, as a candidate drug for AD, which potentially targets both astrocytes and microglia. It has already shown consistent beneficial effects in basic experimental and clinical studies. We also highlight the recent evidence linking peripheral inflammation and neuroinflammation. Several chronic systemic inflammatory diseases, such as obesity, type 2 diabetes mellitus, and periodontitis, can cause immune priming or adverse activation of glia thus exacerbating neuroinflammation and increasing risk or facilitating progression of AD. Therefore, reducing peripheral inflammation is a potentially effective strategy for lowering AD prevalence.

    DOI: 10.2174/1570159X18666201111104509

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  • Drug offenses in the Tokyo metropolitan area: Trends for 2016-2018.

    15. Inoue K, Hashioka S, Takeshita H, Fujita Y, Moriwaki S, Murayama Y, Fujita Y, Matsumoto H, Takeichi N, Hoshi M, Noso Y, Okazaki Y

    Legal Medicine   2020.11

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  • Drug offenses in the Tokyo Metropolitan Area: Trends for 2016–2018

    Ken Inoue, Sadayuki Hashioka, Haruo Takeshita, Yasuyuki Fujita, Shigeto Moriwaki, Yuri Murayama, Yoshitsugu Fujita, Hidehiko Matsumoto, Nobuo Takeichi, Masaharu Hoshi, Yoshihiro Noso, Yuji Okazaki

    Legal Medicine   47   2020.11

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    DOI: 10.1016/j.legalmed.2020.101739

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  • Real-World Preventive Effects of Suvorexant in Intensive Care Delirium: A Retrospective Cohort Study

    Muneto Izuhara, Hisae Kihara Izuhara, Keiko Tsuchie, Tomoko Araki, Tsukasa Ito, Kouhei Sato, Shoko Miura, Koji Otsuki, Michiharu Nagahama, Maiko Hayashida, Sadayuki Hashioka, Rei Wake, Tomohiro Kimura, Shusaku Tsumoto, Yoji Saito, Masatoshi Inagaki

    The Journal of clinical psychiatry   81 ( 6 )   2020.10

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    DOI: 10.4088/JCP.20m13362

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  • Real-world preventive effects of suvorexant in intensive care delirium: A retrospective cohort study Reviewed

    Izuhara M, Izuhara H, Tsuchie K, Araki T, Ito T, Sato K, Miura S, Otsuki K, Nagahama M, Hayashida M, Hashioka S, Wake R, Kimura T, Tsumoto S, Saito Y, Inagaki M

    Journal of Clinical Psychiatry   2020.10

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  • Glia and Glial Growth Factors as New Therapeutic Targets in Neuropsychiatric Disorders. International journal

    Sadayuki Hashioka

    CNS & neurological disorders drug targets   2020.9

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  • Risk of an Increase in Suicide Rates Associated With Economic Downturn due to COVID-19 Pandemic

    Ken Inoue, Sadayuki Hashioka, Noriyuki Kawano

    Asia-Pacific Journal of Public Health   32 ( 6-7 )   367   2020.9

  • mECTにより心室性期外収縮が頻発したが、抗不整脈薬を投与することで完遂できた老年期うつ病の1例

    三浦 章子, 伊藤 司, 佐藤 皓平, 錦織 光, 伊豆原 宗人, 松田 泰行, 金山 三紗子, 山下 智子, 長濱 道治, 大朏 孝治, 林田 麻衣子, 岡崎 四方, 橋岡 禎征, 和氣 玲, 稲垣 正俊

    精神神経学雑誌   122 ( 9 )   702 - 703   2020.9

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  • 夜間頻尿・不定愁訴に対して八味地黄丸が有用と思われたアルツハイマー型認知症の1例

    長濱 道治, 河野 公範, 伊藤 司, 佐藤 皓平, 錦織 光, 伊豆原 宗人, 松田 泰行, 金山 三紗子, 三浦 章子, 山下 智子, 大朏 孝治, 林田 麻衣子, 岡崎 四方, 橋岡 禎征, 和氣 玲, 稲垣 正俊, 堀口 淳

    精神神経学雑誌   122 ( 9 )   703 - 703   2020.9

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  • 夜間頻尿・不定愁訴に対して八味地黄丸が有用と思われたアルツハイマー型認知症の1例

    長濱 道治, 河野 公範, 伊藤 司, 佐藤 皓平, 錦織 光, 伊豆原 宗人, 松田 泰行, 金山 三紗子, 三浦 章子, 山下 智子, 大朏 孝治, 林田 麻衣子, 岡崎 四方, 橋岡 禎征, 和氣 玲, 稲垣 正俊, 堀口 淳

    精神神経学雑誌   122 ( 9 )   703 - 703   2020.9

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  • Tailgating (aori-unten): A recent major social issue in Japan

    Ken Inoue, Sadayuki Hashioka, Haruo Takeshita

    Medicine, Science and the Law   60 ( 3 )   234   2020.7

  • Glia and glial growth factors as new therapeutic targets in neuropsychiatric disorders Invited Reviewed

    Hashioka S

    CNS & Neurological Disorders - Drug Targets   2020.7

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  • Tailgating (aori-unten): A recent major social issue in Japan Reviewed

    Inoue K, Hashioka S, Takeshita H

    Medicine, Science and the Law   2020.7

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  • Low serum levels of fibroblast growth factor 2 in Gunn rats: A hyperbilirubinemia animal model of schizophrenic symptoms Reviewed

    Hayashida M, Hashioka S, Hayashida K, Miura S, Tsuchie K, Araki T, Izuhara M, Kanayama M, Otsuki K, Nagahama M, Jaya AM, WakeR, Oh-Nishi A, Horiguchi J, Miyaoka T, Inagaki M.

    CNS & Neurological Disorders - Drug Targets   2020.7

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  • Risk of an increase in suicide rates associated with economic downturn due to COVID-19 pandemic Reviewed

    Inoue K, Hashioka S, Kawano N

    Asia-Pacific Journal of Public Health   2020.7

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  • 統合失調症合併不眠症に対し認知行動療法が奏功した一例

    伊豆原 宗人, 松田 泰行, 齊藤 安美, 小池 昌弘, 金山 三紗子, 三木 啓之, 三浦 章子, 山下 智子, 大朏 孝治, 河野 公範, 長濱 道治, 林田 麻衣子, 安田 英彰, 岡崎 四方, 橋岡 禎征, 和氣 玲, 宮岡 剛, 稲垣 卓司, 堀口 淳

    心身医学   60 ( 4 )   368 - 368   2020.5

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  • 胸部不快感を伴う不安に対して漢方薬が有用であった3症例

    長濱 道治, 伊豆原 宗人, 松田 泰行, 小池 昌弘, 三木 啓之, 金山 三紗子, 三浦 章子, 山下 智子, 大朏 孝治, 河野 公範, 林田 麻衣子, 岡崎 四方, 橋岡 禎征, 和氣 玲, 宮岡 剛, 堀口 淳

    心身医学   60 ( 4 )   369 - 369   2020.5

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  • The effectiveness of electroconvulsive therapy for psychiatric symptoms and cognitive fluctuations similar to dementia with Lewy bodies: a case report

    Muneto Izuhara, Sadayuki Hashioka, Takeki Sato, Hikaru Nishikoori, Masahiro Koike, Hiroyuki Matsuda, Misako Kanayama, Syoko Miura, Satoko Yamashita, Michiharu Nagahama, Koji Otsuki, Maiko Hayashida, Rei Wake, Tsuyoshi Miyaoka, Masatoshi Inagaki, Jun Horiguchi

    Psychogeriatrics   20 ( 2 )   229 - 231   2020.3

  • SELF-ASSESSED COMPETENCE IN PROVIDING CARE TO THE SEVERELY ILL PATIENTS AMONG NURSES AND RELATIVES/CAREGIVERS IN KAZAKHSTAN

    A. Sharapiyeva, R. Abzalova, K. Inoue, S. Hashioka, Zh Zhetmekova

    Georgian medical news   ( 300 )   128 - 134   2020.3

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  • Self-assessed competence in providing care to the severely ill patients among nurses and relatives/caregivers in Kazakhstan Reviewed

    Sharapiyeva A, Abzalova R, Inoue K, Hashioka S, Zhetmekova Z

    Georgian Medical News   2020.3

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  • Changes in the status of COVID-19 over time necessitate major changes in academics Reviewed

    Inoue K, Hashioka S, Inagaki T, Takeshita H, Fujita Y, Ohira Y

    International Maritime Health   2020.3

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  • Low serum levels of fibroblast growth factor 2 in gunn rats: A hyper-bilirubinemia animal model of schizophrenic symptoms

    Maiko Hayashida, Sadayuki Hashioka, Kenji Hayashida, Shoko Miura, Keiko Tsuchie, Tomoko Araki, Muneto Izuhara, Misako Kanayama, Koji Otsuki, Michiharu Nagahama, Muhammad Alim Jaya, Ryosuke Arauchi, Rei Wake, Arata Oh-Nishi, Jun Horiguchi, Tsuyoshi Miyaoka, Masatoshi Inagaki, Eishin Morita

    CNS and Neurological Disorders - Drug Targets   19 ( 7 )   503 - 508   2020

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  • Changes in the status of COVID-19 over time necessitate major changes in academics

    Ken Inoue, Sadayuki Hashioka, Takuji Inagaki, Haruo Takeshita, Yasuyuki Fujita, Yoshiyuki Ohira

    International maritime health   71 ( 3 )   215   2020

  • More effective suicide prevention measures are needed for young japanese: A comparison of japanese and hungarian suicide rates

    Ken Inoue, Sadayuki Hashioka, Nobuo Takeichi, Yoshihiro Noso, Masaharu Hoshi, Haruo Takeshita, Yasuyuki Fujita, Yersin T. Zhunusov, Madina Apbassova, Dariya Shabdarbayeva, Nailya Chaizhunussova

    International Medical Journal   26 ( 6 )   453 - 454   2019.12

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  • The risk of overwork death (karoshi) in the wake of natural disasters

    Ken Inoue, Yuri Murayama, Sadayuki Hashioka

    BMJ   opinion November 29   2019.11

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  • Electroconvulsive shock restores the decreased coverage of brain blood vessels by astrocytic endfeet and ameliorates depressive-like behavior

    Ilhamuddin A. Azis, Sadayuki Hashioka, Keiko Tsuchie, Tsuyoshi Miyaoka, Rostia A. Abdullah, Erlyn Limoa, Ryosuke Arauchi, Ken Inoue, Shoko Miura, Muneto Izuhara, Misako Kanayama, Koji Otsuki, Michiharu Nagahama, Kiminori Kawano, Tomoko Araki, Maiko Hayashida, Rei Wake, Arata Oh-Nishi, Andi J. Tanra, Jun Horiguchi, Masatoshi Inagaki

    Journal of Affective Disorders   257   331 - 339   2019.10

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    DOI: 10.1016/j.jad.2019.07.008

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  • Aspects of a Large Tsunami That Struck the Sunda Strait in Indonesia: Lessons for Japan and the Rest of the World

    Ken Inoue, Haruo Takeshita, Sadayuki Hashioka, Nobuo Takeichi, Yasuyuki Fujita

    Asia-Pacific Journal of Public Health   31 ( 6 )   574 - 575   2019.9

  • The possible causal link of periodontitis to neuropsychiatric disorders: More than psychosocial mechanisms

    Sadayuki Hashioka, Ken Inoue, Tsuyoshi Miyaoka, Maiko Hayashida, Rei Wake, Arata Oh-Nishi, Masatoshi Inagaki

    International Journal of Molecular Sciences   20 ( 15 )   2019.8

  • Parvalbumin-positive GABAergic interneurons deficit in the hippocampus in Gunn rats: A possible hyperbilirubinemia-induced animal model of schizophrenia

    M. Hayashida, Tsuyoshi Miyaoka, K. Tsuchie, Tomoko Araki, Muneto Izuhara, S. Miura, Misako Kanayama, Koji Ohtsuki, Michiharu Nagahama, Ilhamuddin Abdul Azis, Rostia Arianna Abdullah, Muhammad Alim Jaya, Ryosuke Arauchi, Sadayuki Hashioka, Rei Wake, Toshiko Tsumori, Jun Horiguchi, A. Oh-Nishi, Masatoshi Inagaki

    Heliyon   5 ( 7 )   2019.7

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    DOI: 10.1016/j.heliyon.2019.e02037

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  • 胸部症状を主訴としたレストレスレッグズ症候群の1例

    長濱 道治, 河野 公範, 錦織 光, 伊豆原 宗人, 松田 泰行, 金山 三紗子, 三浦 章子, 山下 智子, 大朏 孝治, 林田 麻衣子, 岡崎 四方, 橋岡 禎征, 和氣 玲, 稲垣 正俊, 堀口 淳

    老年精神医学雑誌   30 ( 増刊II )   179 - 179   2019.6

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  • 心因反応が疑われたが、精神病症状を呈したため電気けいれん療法を行った精神遅滞を伴う統合失調症の一症例

    長濱 道治, 河野 公範, 伊藤 司, 錦織 光, 伊豆原 宗人, 小池 昌弘, 松田 泰行, 三木 啓之, 金山 三紗子, 三浦 章子, 山下 智子, 大朏 孝治, 林田 麻衣子, 岡崎 四方, 橋岡 禎征, 和氣 玲, 宮岡 剛, 稲垣 正俊, 堀口 淳

    精神神経学雑誌   ( 2019特別号 )   S426 - S426   2019.6

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  • The Need to Develop a Strategy With an Evidence-Based Guideline for the Prevention of Gaming Disorder

    Sadayuki Hashioka, Ken Inoue, Haruo Takeshita, Masanori Kamura, Yasuyuki Fujita

    Asia-Pacific Journal of Public Health   31 ( 3 )   267 - 268   2019.4

  • 高齢発症てんかんを合併したと思われるアルツハイマー型認知症の1例

    長濱 道治, 河野 公範, 小池 昌弘, 松田 泰行, 金山 三紗子, 三浦 章子, 山下 智子, 大朏 孝治, 林田 麻衣子, 岡崎 四方, 橋岡 禎征, 和氣 玲, 宮岡 剛, 稲垣 正俊, 堀口 淳

    総合病院精神医学   31 ( 1 )   91 - 91   2019.1

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  • Decreased Clostridium Abundance after Electroconvulsive Therapy in the Gut Microbiota of a Patient with Schizophrenia

    Misako Kanayama, Maiko Hayashida, Sadayuki Hashioka, Tsuyoshi Miyaoka, Masatoshi Inagaki

    Case Reports in Psychiatry   2019   2019

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    DOI: 10.1155/2019/4576842

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  • Important measures for dealing with future urban earthquakes in japan: Lessons from the 2018 northern osaka prefecture earthquake

    Ken Inoue, Sadayuki Hashioka, Yasuyuki Fujita, Haruo Takeshita

    International Medical Journal   26 ( 5 )   442 - 443   2019

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  • High serum cortisol levels as a potential indicator for changes in well-regulated daily life among junior high school students

    Ken Inoue, Sadayuki Hashioka, Haruo Takeshita, Masanori Kamura, Yasuyuki Fujita

    Tohoku Journal of Experimental Medicine   249 ( 3 )   143 - 146   2019

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    DOI: 10.1620/tjem.249.143

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  • Clostridium butyricum MIYAIRI 588 as Adjunctive Therapy for Treatment-Resistant Major Depressive Disorder: A Prospective Open-Label Trial

    Tsuyoshi Miyaoka, Misako Kanayama, Rei Wake, Sadayuki Hashioka, Maiko Hayashida, Michiharu Nagahama, Shihoh Okazaki, Satoko Yamashita, Shoko Miura, Hiroyuki Miki, Hiroyuki Matsuda, Masahiro Koike, Muneto Izuhara, Tomoko Araki, Keiko Tsuchie, Ilhamuddin Abdul Azis, Ryosuke Arauchi, Rostia Arianna Abdullah, Arata Oh-Nishi, Jun Horiguchi

    Clinical Neuropharmacology   41 ( 5 )   151 - 155   2018.9

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    DOI: 10.1097/WNF.0000000000000299

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  • Gunn rats with glial activation in the hippocampus show prolonged immobility time in the forced swimming test and tail suspension test

    Ryosuke Arauchi, Sadayuki Hashioka, Keiko Tsuchie, Tsuyoshi Miyaoka, Toshiko Tsumori, Erlyn Limoa, Ilhamuddin A. Azis, Arata Oh-Nishi, Shoko Miura, Koji Otsuki, Misako Kanayama, Muneto Izuhara, Michiharu Nagahama, Kiminori Kawano, Tomoko Araki, Kristian Liaury, Rostia A. Abdullah, Rei Wake, Maiko Hayashida, Ken Inoue, Jun Horiguchi

    Brain and Behavior   8 ( 8 )   2018.8

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    DOI: 10.1002/brb3.1028

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  • Implications of systemic inflammation and periodontitis for major depression

    Sadayuki Hashioka, Ken Inoue, Maiko Hayashida, Rei Wake, Arata Oh-Nishi, Tsuyoshi Miyaoka

    Frontiers in Neuroscience   12 ( JUL )   2018.7

  • Cognitive behavioral therapy for insomnia as adjunctive therapy to antipsychotics in Schizophrenia: A case report

    Muneto Izuhara, Hiroyuki Matsuda, Ami Saito, Maiko Hayashida, Syoko Miura, Arata Oh-Nishi, Ilhamuddin Abdul Azis, Rostia Arianna Abdullah, Keiko Tsuchie, Tomoko Araki, Arauchi Ryousuke, Misako Kanayama, Sadayuki Hashioka, Rei Wake, Tsuyoshi Miyaoka, Jun Horiguchi

    Frontiers in Psychiatry   9 ( JUN )   2018.6

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    DOI: 10.3389/fpsyt.2018.00260

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  • 低ナトリウム血症に伴うせん妄が疑われたレビー小体病の1例

    長濱 道治, 小池 昌弘, 松田 泰行, 金山 三紗子, 三浦 章子, 山下 智子, 大朏 孝治, 河野 公範, 林田 麻衣子, 岡崎 四方, 橋岡 禎征, 和氣 玲, 宮岡 剛, 稲垣 正俊, 堀口 淳

    老年精神医学雑誌   29 ( 増刊II )   173 - 173   2018.6

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  • 低ナトリウム血症に伴うせん妄が疑われたレビー小体病の1例

    長濱 道治, 小池 昌弘, 松田 泰行, 金山 三紗子, 三浦 章子, 山下 智子, 大朏 孝治, 河野 公範, 林田 麻衣子, 岡崎 四方, 橋岡 禎征, 和氣 玲, 宮岡 剛, 稲垣 正俊, 堀口 淳

    老年精神医学雑誌   29 ( 増刊II )   173 - 173   2018.6

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  • 治療抵抗性統合失調症に対する治療としての骨髄移植の可能性

    宮岡 剛, 和気 玲, 橋岡 禎征, 林田 麻衣子, 大西 新, 伊豆原 宗人, 土江 景子, 荒木 智子, 荒内 亮介, 堀口 淳

    精神神経学雑誌   ( 2018特別号 )   S571 - S571   2018.6

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  • Gunnラットにおけるうつ様行動(Depression-like Behavior in Gunn Rats)

    Azis Ilhamuddin A., 橋岡 禎征, 宮岡 剛, 土江 景子, 荒内 亮輔, 三浦 章子, 伊豆原 宗人, 金山 三紗子, Abdullah Rostia Arianna, Limoa Erlyn, 和氣 玲, 林田 麻衣子, 荒木 智子, 古屋 智英, Liaury Kristian, Tanra Andi J., 堀口 淳

    精神神経学雑誌   120 ( 4 )   336 - 336   2018.4

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  • BPSDに対してエスシタロプラムが有用と思われたアルツハイマー型認知症の2例

    長濱 道治, 伊豆原 宗人, 松田 泰行, 小池 昌弘, 三木 啓之, 金山 三紗子, 田中 一平, 三浦 章子, 山下 智子, 大朏 孝治, 河野 公範, 林田 麻衣子, 岡崎 四方, 橋岡 禎征, 和氣 玲, 宮岡 剛, 堀口 淳, 福田 賢司

    精神神経学雑誌   120 ( 1 )   68 - 68   2018.1

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  • Long-Term Effects Of Combined Treatment With Memantine And Donepezil On Alzheimer's Disease Patients: 72-Week Study

    Rei Wake, Tomoko Araki, Tsuyoshi Miyaoka, Michiharu Nagahama, Motohide Furuya, Maiko Hayashida, Sadayuki Hashioka, Jun Horiguchi

    Neuropsychiatry   08 ( 03 )   2018

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    DOI: 10.4172/neuropsychiatry.1000421

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  • Salivary alpha-amylase activity levels in catatonic schizophrenia decrease after electroconvulsive therapy

    Misako Kanayama, Tsuyoshi Miyaoka, Tomoko Araki, Maiko Hayashida, Sadayuki Hashioka, Jun Horiguchi

    Case Reports in Psychiatry   2018   2018

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    DOI: 10.1155/2018/2623585

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  • A social issue that will substantially impact Japan 20 years later: Measures to address social withdrawal need to be promptly promoted.

    Ken Inoue, Tsuyoshi Miyaoka, Sadayuki Hashioka, Jun Horiguchi

    British Journal of Psychiatry   eLetter November 28   2017.11

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  • Remission of psychosis in treatment-resistant schizophrenia following bone marrow transplantation: A case report

    Tsuyoshi Miyaoka, Rei Wake, Sadayuki Hashioka, Maiko Hayashida, Arata Oh-Nishi, Ilhamuddin Abdul Azis, Muneto Izuhara, Keiko Tsuchie, Tomoko Araki, Ryosuke Arauchi, Rostia Arianna Abdullah, Jun Horiguchi

    Frontiers in Psychiatry   8 ( SEP )   2017.9

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    DOI: 10.3389/fpsyt.2017.00174

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  • Metabolomics analysis implies noninvolvement of the kynurenine pathway neurotoxins in the interferon-gamma- induced neurotoxicity of adult human astrocytes

    Sadayuki Hashioka, Hideyuki Suzuki, Daisuke Nakajima, Tsuyoshi Miyaoka, Rei Wake, Maiko Hayashida, Jun Horiguchi, Andis Klegeris

    Neuropsychiatry   07 ( 02 )   2017

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    DOI: 10.4172/neuropsychiatry.1000192

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  • Electroconvulsive shock attenuated microgliosis and astrogliosis in the hippocampus and ameliorated schizophrenia-like behavior of Gunn rat

    Erlyn Limoa, Sadayuki Hashioka, Tsuyoshi Miyaoka, Keiko Tsuchie, Ryosuke Arauchi, Ilhamuddin A. Azis, Rei Wake, Maiko Hayashida, Tomoko Araki, Motohide Furuya, Kristian Liaury, Andi J. Tanra, Jun Horiguchi

    Journal of Neuroinflammation   13 ( 1 )   2016.9

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    DOI: 10.1186/s12974-016-0688-2

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  • Electroconvulsive shock ameliorated the schizophrenia-like behavior and attenuated the glial activation in the hippocampus of Gunn Rat Reviewed

    Erlyn Limoa Ilhamuddin Abdul Aziz, Tomoko Araki, Ryosuke Arauchi, Motohide Furuya, Sadayuki Hashioka, Maiko Hayashida, Jun Horiguchi, Kristian Liaury, Tsuyoshi Miyaoka, Andi Jayalangkara Tanra, Keiko Tsuchie, Rei Wake

    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY   19   186 - 186   2016.6

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  • The comparison with galantamine and donepezil on Alzheimer's Disease patients and its relationship with cerebral blood flow Reviewed

    Rei Wake, Tomoko Araki, Tsuyoshi Miyaoka, Michiharu Nagahama, Erlyn Liemoa, Sadayuki Hashioka, Jun Horiguchi

    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY   19   265 - 266   2016.6

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  • Efficacy and Safety of Sansoninto for Insomnia in Child and Adolescent Patients: An Open-Label Study Reviewed

    Tsuyoshi Miyaoka, Ilham Abdul Aziz, Tomoko Araki, Ryosuke Arauch, Motohide Furuya, Sadayuki Hashioka, Maiko Hayashida, Jun Horiguchi, Kiminori Kawano, Kristian Liaury, Erlyn Limoa, Romana Sharmeen, Keiko Tsuchie, Rei Wake

    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY   19   177 - 177   2016.6

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  • The effect of Ketamine: Gunn rat as a Schizophrenia animal model Reviewed

    Maiko Hayashida, Tomoko Araki, Sadayuki Hashioka, Jun Horiguchi, Kiminori Kawano, Syoko Miura, Tsuyoshi Miyaoka, Michiaru Nagahama, Keiko Tsuchie, Rei Wake

    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY   19   181 - 182   2016.6

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  • Gunn rats show depression-like behavior and microglial activation in the hippocampus Reviewed

    Ryosuke Arauchi, Tomoko Araki, Ilhamuddin Abdul Azis, Sadayuki Hashioka, Maiko Hayashida, Jun Horiguchi, Erlyn Limoa, Tsuyoshi Miyaoka, Keiko Tsuchie, Rei Wake

    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY   19   97 - 97   2016.6

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  • Effects of yokukansan, a Japanese kampo medicine for symptoms associated autism spectrum disorder

    Rei Wake, Tsuyoshi Miyaoka, Motohide Furuya, Sadayuki Hashioka, Jun Horiguchi

    CNS and Neurological Disorders - Drug Targets   15 ( 5 )   551 - 563   2016.5

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    DOI: 10.2174/1871527315666160413120541

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  • Regional cerebral blood flow in late-onset schizophrenia: a SPECT study using 99mTc-ECD

    Rei Wake, Tsuyoshi Miyaoka, Tomoko Araki, Kazunori Kawakami, Motohide Furuya, Erlyn Limoa, Sadayuki Hashioka, Jun Horiguchi

    European Archives of Psychiatry and Clinical Neuroscience   266 ( 1 )   3 - 12   2016.2

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    DOI: 10.1007/s00406-015-0607-z

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  • Aceruloplasminemia with psychomotor excitement and neurological sign was improved by minocycline (Case Report)

    Maiko Hayashida, Sadayuki Hashioka, Hiroyuki Miki, Michiharu Nagahama, Rei Wake, Tsuyoshi Miyaoka, Jun Horiguchi

    Medicine (United States)   95 ( 19 )   2016

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    DOI: 10.1097/MD.0000000000003594

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  • 心因性発作に半夏厚朴湯が著効した1例

    山下, 智子, 三浦, 章子, 松田, 泰行, 三木, 啓之, 金山, 三紗子, 田中, 一平, 長濱, 道治, 岡崎, 四方, 林田, 麻衣子, 和氣, 玲, 橋岡, 禎征, 宮岡, 剛, 堀口, 淳

    漢方と診療   24 ( 6 )   2016

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  • Analysis of oxidative stress expressed by urinary level of biopyrrins and 8-hydroxydeoxyguanosine in patients with chronic schizophrenia

    Tsuyoshi Miyaoka, Masa Ieda, Sadayuki Hashioka, Rei Wake, Motohide Furuya, Kristian Liaury, Maiko Hayashida, Keiko Tsuchie, Ryosuke Arauchi, Tomoko Araki, Izuru Shioji, Satoko Ezoe, Ken Inoue, Tokio Yamaguchi, Jun Horiguchi

    Psychiatry and Clinical Neurosciences   69 ( 11 )   693 - 698   2015.11

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    DOI: 10.1111/pcn.12319

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  • Can inhibition of microglial activation cure schizophrenia?

    Sadayuki Hashioka, Patrick L. McGeer, Tsuyoshi Miyaoka, Rei Wake, Jun Horiguchi

    Schizophrenia Research   168 ( 1-2 )   583 - 584   2015.10

  • Ramelteon as adjunctive therapy for delirium referred to a consultation-liaison psychiatry service: A retrospective analysis

    Motohide Furuya, Tsuyoshi Miyaoka, Hideaki Yasuda, Rei Wake, Sadayuki Hashioka, Shoko Miura, Michiharu Nagahama, Tomoko Araki, Jun Horiguchi

    International Journal of Geriatric Psychiatry   30 ( 9 )   994 - 995   2015.9

  • Efficacy and safety of yokukansan in treatment-resistant schizophrenia: A randomized, double-blind, placebo-controlled trial (a Positive and Negative Syndrome Scale, five-factor analysis)

    Tsuyoshi Miyaoka, Motohide Furuya, Jun Horiguchi, Rei Wake, Sadayuki Hashioka, Masaya Tohyama, Norio Mori, Yoshio Minabe, Masaomi Iyo, Shyuichi Ueno, Sachiko Ezoe, Kenta Murotani, Syuzo Hoshino, Haruo Seno

    Psychopharmacology   232 ( 1 )   155 - 164   2015.1

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    DOI: 10.1007/s00213-014-3645-8

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  • Efficacy and safety of yokukansan in treatment-resistant schizophrenia: A randomized, multicenter, double-blind, placebo-controlled trial

    Tsuyoshi Miyaoka, Motohide Furuya, Jun Horiguchi, Rei Wake, Sadayuki Hashioka, Masaya Thoyama, Kenta Murotani, Norio Mori, Yoshio Minabe, Masaomi Iyo, Shuichi Ueno, Sachiko Ezoe, Syuzo Hoshino, Haruo Seno

    Evidence-based Complementary and Alternative Medicine   2015   2015

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    DOI: 10.1155/2015/201592

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  • Interferon-γ-induced neurotoxicity of human astrocytes

    Sadayuki Hashioka, Edith G. McGeer, Tsuyoshi Miyaoka, Rei Wake, Jun Horiguchi, Patrick L. McGeer

    CNS and Neurological Disorders - Drug Targets   14 ( 2 )   251 - 256   2015

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    DOI: 10.2174/1871527314666150217122305

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  • Gold drug auranofin could reduce neuroinflammation by inhibiting microglia cytotoxic secretions and primed respiratory burst

    Jocelyn M. Madeira, Ekta Bajwa, Maegan J. Stuart, Sadayuki Hashioka, Andis Klegeris

    Journal of Neuroimmunology   276 ( 1-2 )   71 - 79   2014.11

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    DOI: 10.1016/j.jneuroim.2014.08.615

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  • The effects of combine treatment of memantine and donepezil on Alzheimer's Disease patients and its relationship with cerebral blood flow in the prefrontal area

    Tomoko Araki, Rei Wake, Tsuyoshi Miyaoka, Kazunori Kawakami, Michiharu Nagahama, Motohide Furuya, Erlyn Limoa, Kristian Liaury, Sadayuki Hashioka, Kenta Murotani, Jun Horiguchi

    International Journal of Geriatric Psychiatry   29 ( 9 )   881 - 889   2014.9

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    DOI: 10.1002/gps.4074

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  • Minocycline improves recognition memory and attenuates microglial activation in Gunn rat: A possible hyperbilirubinemia-induced animal model of schizophrenia

    Kristian Liaury, Tsuyoshi Miyaoka, Toshiko Tsumori, Motohide Furuya, Sadayuki Hashioka, Rei Wake, Keiko Tsuchie, Michiyo Fukushima, Erlyn Limoa, Andi Jayalangkara Tanra, Jun Horiguchi

    Progress in Neuro-Psychopharmacology and Biological Psychiatry   50   184 - 190   2014.4

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    DOI: 10.1016/j.pnpbp.2013.12.017

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  • Purinergic responses of calcium-dependent signaling pathways in cultured adult human astrocytes

    Sadayuki Hashioka, Yun F. Wang, Jonathan P. Little, Hyun B. Choi, Andis Klegeris, Patrick L. McGeer, James G. McLarnon

    BMC Neuroscience   15   2014.1

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    DOI: 10.1186/1471-2202-15-18

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  • Yokukansan promotes hippocampal neurogenesis associated with the suppression of activated microglia in Gunn rat

    Motohide Furuya, Tsuyoshi Miyaoka, Toshiko Tsumori, Kristian Liaury, Sadayuki Hashioka, Rei Wake, Keiko Tsuchie, Michiyo Fukushima, Satoko Ezoe, Jun Horiguchi

    Journal of Neuroinflammation   10   2013.12

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    DOI: 10.1186/1742-2094-10-145

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  • Differential pathways for interleukin-1β production activated by chromogranin A and amyloid β in microglia

    Zhou Wu, Li Sun, Sadayuki Hashioka, Sheng Yu, Claudia Schwab, Ryo Okada, Yoshinori Hayashi, Patrick L. McGeer, Hiroshi Nakanishi

    Neurobiology of Aging   34 ( 12 )   2715 - 2725   2013.12

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    DOI: 10.1016/j.neurobiolaging.2013.05.018

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  • Novel protective properties of auranofin: Inhibition of human astrocyte cytotoxic secretions and direct neuroprotection

    J. M. Madeira, C. J. Renschler, B. Mueller, S. Hashioka, D. L. Gibson, A. Klegeris

    Life Sciences   92 ( 22 )   1072 - 1080   2013.6

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    DOI: 10.1016/j.lfs.2013.04.005

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  • Yokukansan (TJ-54) for treatment of very-late-onset schizophrenia-like psychosis: An open-label study

    Tsuyoshi Miyaoka, Rei Wake, Motohide Furuya, Kristian Liaury, Masa Ieda, Kazunori Kawakami, Keiko Tsuchie, Michiyo Fukushima, Kotomi Ishihara, Tomoko Araki, Sadayuki Hashioka, Jun Horiguchi

    Phytomedicine   20 ( 7 )   654 - 658   2013.5

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    DOI: 10.1016/j.phymed.2013.01.007

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  • Glia: An important target for anti-inflammatory and antidepressant activity

    Sadayuki Hashioka, Tsuyoshi Miyaoka, Rei Wake, Motohide Furuya, Jun Horiguchi

    Current Drug Targets   14 ( 11 )   1322 - 1328   2013

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    DOI: 10.2174/13894501113146660214

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  • Inhibition of human astrocyte and microglia neurotoxicity by calcium channel blockers

    Sadayuki Hashioka, Andis Klegeris, Patrick L. McGeer

    Neuropharmacology   63 ( 4 )   685 - 691   2012.9

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    DOI: 10.1016/j.neuropharm.2012.05.033

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  • The histone deacetylase inhibitor suberoylanilide hydroxamic acid attenuates human astrocyte neurotoxicity induced by interferon-γ

    Sadayuki Hashioka, Andis Klegeris, Patrick L. McGeer

    Journal of Neuroinflammation   9   2012.5

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    DOI: 10.1186/1742-2094-9-113

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  • Aripiprazole inhibits superoxide generation from phorbol-myristate-acetate (PMA)-stimulated microglia in vitro: Implication for antioxidative psychotropic actions via microglia

    Takahiro A. Kato, Akira Monji, Keiji Yasukawa, Yoshito Mizoguchi, Hideki Horikawa, Yoshihiro Seki, Sadayuki Hashioka, Youn Hee Han, Mina Kasai, Noriyuki Sonoda, Eiichi Hirata, Yasutaka Maeda, Toyoshi Inoguchi, Hideo Utsumi, Shigenobu Kanba

    Schizophrenia Research   129 ( 2-3 )   172 - 182   2011.7

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    DOI: 10.1016/j.schres.2011.03.019

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  • Proton pump inhibitors reduce interferon-γ-induced neurotoxicity and STAT3 phosphorylation of human astrocytes

    Sadayuki Hashioka, Andis Klegeris, Patrick L. Mcgeer

    GLIA   59 ( 5 )   833 - 840   2011.5

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    DOI: 10.1002/glia.21157

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  • Cultured adult porcine astrocytes and microglia express functional interferon-γ receptors and exhibit toxicity towards SH-SY5Y cells

    Vlad A. Ionescu, Erika B. Villanueva, Sadayuki Hashioka, Manpreet Bahniwal, Andis Klegeris

    Brain Research Bulletin   84 ( 3 )   244 - 251   2011.2

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    DOI: 10.1016/j.brainresbull.2010.12.011

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  • STAT3 inhibitors attenuate interferon-γ-induced neurotoxicity and inflammatory molecule production by human astrocytes

    Sadayuki Hashioka, Andis Klegeris, Hong Qing, Patrick L. McGeer

    Neurobiology of Disease   41 ( 2 )   299 - 307   2011.2

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    DOI: 10.1016/j.nbd.2010.09.018

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  • Pyrazole compound 2-MBAPA as a novel inhibitor of microglial activation and neurotoxicity in vitro and in vivo

    Sadayuki Hashioka, James G. McLarnon, Jae K. Ryu, Amal M. Youssef, Alaa S. Abd-El-Aziz, Edward G. Neeland, Andis Klegeris

    Journal of Alzheimer's Disease   27 ( 3 )   531 - 541   2011

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    DOI: 10.3233/JAD-2011-110698

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  • Antidepressants and neuroinflammation: Can antidepressants calm glial rage down?

    S. Hashioka

    Mini-Reviews in Medicinal Chemistry   11 ( 7 )   555 - 564   2011

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    DOI: 10.2174/138955711795906888

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  • Anti-neuroinflammatory effects of psychopharmaceuticals: Further than monoamine modulators

    Sadayuki Hashioka

    Mini-Reviews in Medicinal Chemistry   11 ( 7 )   553 - 554   2011

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    DOI: 10.2174/138955711795906914

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  • Anti-inflammatory properties of antipsychotics via microglia modulations: Are antipsychotics a 'fire extinguisher' in the brain of schizophrenia?

    T. A. Kato, A. Monji, Y. Mizoguchi, S. Hashioka, H. Horikawa, Y. Seki, M. Kasai, H. Kasai, H. Utsumi, S. Kanba

    Mini-Reviews in Medicinal Chemistry   11 ( 7 )   565 - 574   2011

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    DOI: 10.2174/138955711795906941

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  • Inhibitory effects of SSRIs on IFN-γ induced microglial activation through the regulation of intracellular calcium

    Hideki Horikawa, Takahiro A. Kato, Yoshito Mizoguchi, Akira Monji, Yoshihiro Seki, Takatoshi Ohkuri, Leo Gotoh, Megumi Yonaha, Tadashi Ueda, Sadayuki Hashioka, Shigenobu Kanba

    Progress in Neuro-Psychopharmacology and Biological Psychiatry   34 ( 7 )   1306 - 1316   2010.10

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    DOI: 10.1016/j.pnpbp.2010.07.015

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  • Differential expression of interferon-γ receptor on human glial cells in vivo and in vitro

    Sadayuki Hashioka, Andis Klegeris, Claudia Schwab, Sheng Yu, Patrick L. McGeer

    Journal of Neuroimmunology   225 ( 1-2 )   91 - 99   2010.8

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    DOI: 10.1016/j.jneuroim.2010.04.023

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  • Brain-derived neurotrophic factor induces sustained elevation of intracellular Ca<sup>2+</sup> in rodent microglia

    Yoshito Mizoguchi, Akira Monji, Takahiro Kato, Yoshihiro Seki, Leo Gotoh, Hideki Horikawa, Satoshi O. Suzuki, Toru Iwaki, Miyuki Yonaha, Sadayuki Hashioka, Shigenobu Kanba

    Journal of Immunology   183 ( 12 )   7778 - 7786   2009.12

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    DOI: 10.4049/jimmunol.0901326

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  • Interferon-γ-dependent cytotoxic activation of human astrocytes and astrocytoma cells

    Sadayuki Hashioka, Andis Klegeris, Claudia Schwab, Patrick L. McGeer

    Neurobiology of Aging   30 ( 12 )   1924 - 1935   2009.12

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    DOI: 10.1016/j.neurobiolaging.2008.02.019

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  • Proton pump inhibitors exert anti-inflammatory effects and decrease human microglial and monocytic THP-1 cell neurotoxicity

    Sadayuki Hashioka, Andis Klegeris, Patrick L. McGeer

    Experimental Neurology   217 ( 1 )   177 - 183   2009.5

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    DOI: 10.1016/j.expneurol.2009.02.002

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  • Anti-inflammatory effects of antidepressants: Possibilities for preventives against alzheimer's disease

    Sadayuki Hashioka, Patrick L. McGeer, Akira Monji, Shigenobu Kanba

    Central Nervous System Agents in Medicinal Chemistry   9 ( 1 )   12 - 19   2009.3

  • Complexity of microglial activation state: Can modifying microglial activation treat Alzheimer's disease?

    Sadayuki Hashioka, Patrick L. McGeer

    Future Neurology   4 ( 2 )   137 - 139   2009

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    DOI: 10.2217/14796708.4.2.137

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  • Inhibitory effects of aripiprazole on interferon-γ-induced microglial activation via intracellular Ca<sup>2+</sup> regulation in vitro

    Takahiro Kato, Yoshito Mizoguchi, Akira Monji, Hideki Horikawa, Satoshi O. Suzuki, Yoshihiro Seki, Toru Iwaki, Sadayuki Hashioka, Shigenobu Kanba

    Journal of Neurochemistry   106 ( 2 )   815 - 825   2008.7

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    DOI: 10.1111/j.1471-4159.2008.05435.x

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  • Prolyl endopeptidase is revealed following SILAC analysis to be a novel mediator of human microglial and THP-1 cell neurotoxicity

    Andis Klegeris, Jane Li, Theo K. Bammler, Jinghua Jin, David Zhu, Daniel T. Kashima, Sheng Pan, Sadayuki Hashioka, John Maguire, Patrick L. Mcgeer, Jing Zhang

    GLIA   56 ( 6 )   675 - 685   2008.4

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    DOI: 10.1002/glia.20645

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  • The effect of atypical antipsychotics, perospirone, ziprasidone and quetiapine on microglial activation induced by interferon-γ

    Qian Bian, Takahiro Kato, Akira Monji, Sadayuki Hashioka, Yoshito Mizoguchi, Hideki Horikawa, Shigenobu Kanba

    Progress in Neuro-Psychopharmacology and Biological Psychiatry   32 ( 1 )   42 - 48   2008.1

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.pnpbp.2007.06.031

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  • Adhesion of exogenous human microglia and THP-1 cells to amyloid plaques of postmortem Alzheimer's disease brain

    Sadayuki Hashioka, Judith Miklossy, Claudia Schwab, Andis Klegeris, Patrick L. McGeer

    Journal of Alzheimer's Disease   14 ( 3 )   345 - 352   2008

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3233/JAD-2008-14309

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  • Antidepressants inhibit interferon-γ-induced microglial production of IL-6 and nitric oxide

    Sadayuki Hashioka, Andis Klegeris, Akira Monji, Takahiro Kato, Makoto Sawada, Patrick L. McGeer, Shigenobu Kanba

    Experimental Neurology   206 ( 1 )   33 - 42   2007.7

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    DOI: 10.1016/j.expneurol.2007.03.022

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  • Risperidone significantly inhibits interferon-γ-induced microglial activation in vitro

    Takahiro Kato, Akira Monji, Sadayuki Hashioka, Shigenobu Kanba

    Schizophrenia Research   92 ( 1-3 )   108 - 115   2007.5

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    DOI: 10.1016/j.schres.2007.01.019

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  • Phosphatidylserine and phosphatidylcholine-containing liposomes inhibit amyloid β and interferon-γ-induced microglial activation

    Sadayuki Hashioka, Youn Hee Han, Shunsuke Fujii, Takahiro Kato, Akira Monji, Hideo Utsumi, Makoto Sawada, Hiroshi Nakanishi, Shigenobu Kanba

    Free Radical Biology and Medicine   42 ( 7 )   945 - 954   2007.4

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    DOI: 10.1016/j.freeradbiomed.2006.12.003

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  • Phospholipids modulate superoxide and nitric oxide production by lipopolysaccharide and phorbol 12-myristate-13-acetate-activated microglia

    Sadayuki Hashioka, Youn Hee Han, Shunsuke Fujii, Takahiro Kato, Akira Monji, Hideo Utsumi, Makoto Sawada, Hiroshi Nakanishi, Shigenobu Kanba

    Neurochemistry International   50 ( 3 )   499 - 506   2007.2

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    DOI: 10.1016/j.neuint.2006.10.006

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  • Different SPECT findings before and after Capgras' syndrome in interictal psychosis

    Hideki Horikawa, Akira Monji, Masayuki Sasaki, Toshihiko Maekawa, Toshiaki Onitsuka, Yoko Nitazaka, Yoji Hirano, Shougo Hirano, Sadayuki Hashioka, Takahiro Kato, Ichiro Yoshida, Shigenobu Kanba

    Epilepsy and Behavior   9 ( 1 )   189 - 192   2006.8

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    DOI: 10.1016/j.yebeh.2006.04.016

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  • Involvement of COX-1 and up-regulated prostaglandin e synthases in phosphatidylserine liposome-induced prostaglandin E<inf>2</inf> production by microglia

    Jian Zhang, Shunsuke Fujii, Zhou Wu, Sadayuki Hashioka, Yoshitaka Tanaka, Akiko Shiratsuchi, Yoshinobu Nakanishi, Hiroshi Nakanishi

    Journal of Neuroimmunology   172 ( 1-2 )   112 - 120   2006.3

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    DOI: 10.1016/j.jneuroim.2005.11.008

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  • Interictal psychosis after stroke with forced normalization [6]

    Tomoyuki Ohara, Akira Monji, Toshiaki Onitsuka, Toshihiko Maekawa, Yoji Hirano, Shogo Hirano, Sadayuki Hashioka, Takahiro Kato, Ichiro Yoshida, Shigenobu Kanba

    Journal of Neuropsychiatry and Clinical Neurosciences   18 ( 4 )   557 - 559   2006

  • Laminin and its related peptides for the treatment of Alzheimer's disease

    Akira Monji, Ken Ichiro Tashiro, Ichiro Yoshida, Sadayuki Hashioka, Takahiro Kato, Shigenobu Kanba

    Current Medicinal Chemistry - Central Nervous System Agents   5 ( 4 )   243 - 247   2005.12

  • Prophylactic Effect of valproate in the treatment for siblings with catatonia: A case report [5]

    Ichiro Yoshida, Akira Monji, Sadayuki Hashioka, Masatoshi Ito, Shigenobu Kanba

    Journal of Clinical Psychopharmacology   25 ( 5 )   504 - 505   2005.10

  • Amyloid-β fibril formation is not necessarily required for microglial activation by the peptides

    Sadayuki Hashioka, Akira Monji, Tadashi Ueda, Shigenobu Kanba, Hiroshi Nakanishi

    Neurochemistry International   47 ( 5 )   369 - 376   2005.10

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    DOI: 10.1016/j.neuint.2005.05.001

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  • SSRI-Induced enuresis: A case report [9]

    Akira Monji, Kazuyuki Yanagimoto, Ichiro Yoshida, Sadayuki Hashioka

    Journal of Clinical Psychopharmacology   24 ( 5 )   564 - 565   2004.10

  • Carbamazepine may trigger new-onset epileptic seizures in an individual with autism spectrum disorders: A case report

    Akira Monji, Toshihiko Maekawa, Kazuyuki Yanagimoto, Ichiro Yoshida, Sadayuki Hashioka

    European Psychiatry   19 ( 5 )   322 - 323   2004.8

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    DOI: 10.1016/j.eurpsy.2004.06.001

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  • Activation of μ-calpain in developing cortical neurons following methylmercury treatment

    Jian Zhang, Ken Ichiro Miyamoto, Sadayuki Hashioka, Hai Peng Hao, Koji Murao, Takaomi C. Saido, Hiroshi Nakanishi

    Developmental Brain Research   142 ( 1 )   105 - 110   2003.4

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    DOI: 10.1016/S0165-3806(03)00057-9

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  • A patient with Cotard syndrome who showed an improvement in single photon emission computed tomography findings after successful treatment with antidepressants

    Sadayuki Hashioka, Akira Monji, Masayuki Sasaki, Ichiro Yoshida, Kanji Baba, Nobutada Tashiro

    Clinical Neuropharmacology   25 ( 5 )   276 - 279   2002.9

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    DOI: 10.1097/00002826-200209000-00011

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  • Amyloid-β-protein (Aβ) (25-35)-associated free radical generation is strongly influenced by the aggregational state of the peptides

    Akira Monji, Hideo Utsumi, Tadashi Ueda, Taiji Imoto, Ichiro Yoshida, Sadayuki Hashioka, Ken Ichiro Tashiro, Nobutada Tashiro

    Life Sciences   70 ( 7 )   833 - 841   2002.1

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    DOI: 10.1016/S0024-3205(01)01451-5

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  • The relationship between Aβ-associated free radical generation and Aβ fibril formation revealed by negative stain electron microscopy and thioflavine-T fluorometric assay

    Akira Monji, Hideo Utsumi, Ichiro Yoshida, Sadayuki Hashioka, Ken ichiro Tashiro, Nobutada Tashiro

    Neuroscience Letters   304 ( 1-2 )   65 - 68   2001.5

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S0304-3940(01)01756-6

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  • The relationship between the aggregational state of the amyloid-β peptides and free radical generation by the peptides

    Akira Monji, Hideo Utsumi, Tadashi Ueda, Taiji Imoto, Ichiro Yoshida, Sadayuki Hashioka, Ken Ichiro Tashiro, Nobutada Tashiro

    Journal of Neurochemistry   77 ( 6 )   1425 - 1432   2001

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1046/j.1471-4159.2001.00392.x

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▼display all

Books

  • すぐ見て・すぐわかり・すぐ使える眼科処方

    橋岡禎征, 稲垣正俊( Role: Joint author)

    南江堂  2022 

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    Language:Japanese   Book type:Scholarly book

MISC

  • ラメルテオンに加えベルソムラを使用することで速やかな症状改善を認めた睡眠覚醒相後退症候群の3例

    伊豆原 宗人, 河野 公範, 大朏 孝治, 橋岡 禎征, 稲垣 正俊

    日本睡眠学会定期学術集会プログラム・抄録集   46回   231 - 231   2021.9

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  • Sex Differences in Sleep Disturbance Related to Rotating Shift Work: A Cross-Sectional Observation Study in Factory Employees

    IZUHARA Muneto, Yasuda Hideaki, IZUHARA Hisae, ARAKI Tomoko, TSUCHIE Keiko, ARAUCHI Ryosuke, ITO Tsukasa, SATO Kohei, NISHIKORI Hikaru, MATSUDA Hiroyuki, KANAYAMA Misako, MIURA Shoko, YAMASHITA Satoko, OTSUKI Koji, NAGAHAMA Michiharu, Hayashida Maiko, HASHIOKA Sadayuki, Wake Rei, INAGAKI Masatoshi

    Shimane Journal of Medical Science   37 ( 1 )   21 - 29   2020.3

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    Language:English   Publisher:Faculty of Medicine, Shimane University  

    To examine the effects of rotating shift work on sleep, mainly focusing on the difference between the sexes. We conducted a sleep quality survey among factory workers using the Pittsburg Sleep Quality Index (PSQI) questionnaire. Out of 635 employees, 562 workers( 319 male and 143 female workers, including 102 male and 18 female rotating shift workers, and 217 male and 125 female nonrotating workers) completed the PSQI questionnaire. Our results showed that women have generally better sleep quality, such as maintaining better concentration than men in dayshift workers. However, this superior sleep quality was not observed in female rotating shift workers. Furthermore, men have worse sleep quantity and quality, whereas female rotating shift workers have difficulty in staying awake during their work regardless of their sleep quantity and/ or quality. In conclusion, female rotating shift workers may experience problems, although their sleep quality and/or quantity does not seem to be worse.

    CiNii Books

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  • グリシン作動性神経系の活動低下をきたす遺伝性疾患に対する当科の介入

    林田 麻衣子, 伊豆原 宗人, 小池 昌弘, 松田 泰行, 三木 啓之, 三浦 章子, 金山 三紗子, 山下 智子, 長濱 道治, 大朏 孝治, 岡崎 四方, 橋岡 禎征, 和気 玲, 美根 潤, 竹谷 健, 宮岡 剛, 堀口 淳

    精神神経学雑誌   ( 2018特別号 )   S370 - S370   2018.6

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  • 統合失調症の前駆期でのバイオマーカーによる酸化ストレス状態の把握と早期診断の可能性

    和気 玲, 宮岡 剛, 稲垣 卓司, 土江 景子, 荒木 智子, 大西 新, 林田 麻衣子, 橋岡 禎征, 堀口 淳

    精神神経学雑誌   ( 2018特別号 )   S572 - S572   2018.6

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  • 治療抵抗性統合失調症に対する治療としての骨髄移植の可能性

    宮岡 剛, 和気 玲, 橋岡 禎征, 林田 麻衣子, 大西 新, 伊豆原 宗人, 土江 景子, 荒木 智子, 荒内 亮介, 堀口 淳

    精神神経学雑誌   ( 2018特別号 )   S571 - S571   2018.6

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  • 二度の手術(下垂体腫瘍摘出術、卵巣・子宮摘出術)で精神症状が変動した成人期ADHDの一例

    山下 智子, 伊豆原 宗人, 小池 昌弘, 松田 泰行, 三木 啓之, 金山 三紗子, 三浦 章子, 河野 公範, 長濱 道治, 大朏 孝治, 林田 麻衣子, 岡崎 四方, 橋岡 禎征, 和気 玲, 宮岡 剛, 西田 朗, 堀口 淳

    精神神経学雑誌   ( 2018特別号 )   S556 - S556   2018.6

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  • Gunnラットにおいて、電気けいれん療法によって統合失調症様行動は軽減し、海馬のCD11bとGFAP発現が低下する(Electroconvulsive Shock Alleviated Schizo-phrenia-like Behavior and Reduced Expression of CDIlb and GFAP in the Hippocampus of Gunn Rat)

    Erlyn Limoa, 橋岡 禎征, 宮岡 剛, 土江 景子, 荒内 亮輔, 和気 玲, 林田 麻衣子, 荒木 智子, Jayalangkara, Tanra Andi, 堀口 淳

    精神神経学雑誌   120 ( 2 )   149 - 149   2018.2

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  • 生活臨床的介入により寛解に至った統合失調症の1例

    伊豆原 宗人, 田中 一平, 松田 泰行, 金山 三紗子, 林田 麻衣子, 岡崎 四方, 橋岡 禎征, 和氣 玲, 宮岡 剛, 堀口 淳

    精神神経学雑誌   120 ( 1 )   67 - 67   2018.1

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  • 修正型電気けいれん療法とクロザピンにより衝動性と問題行動が改善した解体型統合失調症の1例

    松田 泰行, 長濱 道治, 林田 麻衣子, 和氣 玲, 橋岡 禎征, 宮岡 剛, 堀口 淳

    精神神経学雑誌   119 ( 6 )   442 - 442   2017.6

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  • 電気けいれんショックによって、Gunnラット海馬におけるmicrogliosisとastrogliosisは減衰し、統合失調症様行動は改善した(Electroconvulsive shock attenuated microgliosis and astrogliosis in the hippocampus and improved schizophrenia-like behavior of Gunn rat)

    Erlyn Limoa, 橋岡 禎征, 宮岡 剛, 土江 景子, 荒内 亮輔, Ilhamuddin Abdul Azis, 和気 玲, 林田 麻衣子, 荒木 智子, 古屋 智英, Kristian Liaury, Jayalangkara, Tanra Andi, 堀口 淳

    精神神経学雑誌   119 ( 6 )   442 - 443   2017.6

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  • 解離性障害や統合失調症の発症を疑われ診断に苦慮した発達障害の1例

    松田 泰行, 長濱 道治, 林田 麻衣子, 和気 玲, 橋岡 禎征, 宮岡 剛, 堀口 淳

    精神神経学雑誌   ( 2017特別号 )   S496 - S496   2017.6

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  • 気分障害が先行した前頭側頭型認知症の3例

    三浦 章子, 長濱 道治, 三木 啓之, 田中 一平, 金山 三紗子, 山下 智子, 林田 麻衣子, 和氣 玲, 橋岡 禎征, 宮岡 剛, 堀口 淳

    精神神経学雑誌   119 ( 6 )   444 - 444   2017.6

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  • アルツハイマー型認知症患者に対するガランタミンの効果

    和気 玲, 荒木 智子, 宮岡 剛, 古屋 智英, 長濱 道治, 林田 麻衣子, 橋岡 禎征, 堀口 淳

    精神神経学雑誌   ( 2016特別号 )   S516 - S516   2016.6

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  • 意欲低下に対して釣藤散が有用と思われた軽度認知障害の1症例

    長濱 道治, 小池 昌弘, 松田 泰行, 三木 啓之, 田中 一平, 三浦 章子, 金山 三紗子, 山下 智子, 河野 公範, 林田 麻衣子, 岡崎 四方, 和氣 玲, 橋岡 禎征, 宮岡 剛, 堀口 淳

    老年精神医学雑誌   27 ( 増刊II )   165 - 165   2016.6

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  • 非けいれん性てんかん重積と診断されたオセルタミビルに起因すると考えられる急性精神病状態の1例

    松田 泰行, 田中 一平, 稲垣 諭史, 林田 麻衣子, 和氣 玲, 橋岡 禎征, 宮岡 剛, 堀口 淳

    精神神経学雑誌   118 ( 2 )   107 - 107   2016.2

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  • Regional cerebral blood flow in late-onset schizophrenia: a SPECT study using 99mTc-ECD (vol 266, pg 3, 2016)

    Rei Wake, Tsuyoshi Miyaoka, Tomoko Araki, Kazunori Kawakami, Motohide Furuya, Erlyn Limoa, Sadayuki Hashioka, Jun Horiguchi

    EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE   266 ( 1 )   13 - 13   2016.2

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  • 活性化ミクログリアの抑制によって統合失調症は治療できるのか?

    橋岡 禎征, 宮岡 剛, 和氣 玲, 林田 麻衣子, 堀口 淳

    精神神経学雑誌   118 ( 2 )   108 - 108   2016.2

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  • Gunnラットにおける電撃ショックで変化した統合失調様行動とグリア活性化(Electroconvulsive shock altered schizophrenia-like behavior and glial activation in Gunn Rat)

    Erlyn Limoa, 橋岡 禎征, 宮岡 剛, 土江 景子, 荒内 亮輔, 和気 玲, 林田 麻衣子, 荒木 智子, Jayalangka Tanra Andi, 堀口 淳

    日本脳科学会プログラム・抄録集   42回   20 - 20   2015.11

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  • 精神運動興奮に至った無セルロプラスミン血症の1例

    林田 麻衣子, 三木 啓之, 安田 英彰, 和氣 玲, 橋岡 禎征, 宮岡 剛, 堀口 淳

    精神神経学雑誌   ( 2015特別 )   S341 - S341   2015.6

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  • 髄膜炎後に多彩な精神症状を呈し、抗NMDA受容体抗体が陽性であった男性例

    三浦 章子, 高吉 宏幸, 長濱 道治, 林田 麻衣子, 和氣 玲, 橋岡 禎征, 宮岡 剛, 堀口 淳

    精神神経学雑誌   117 ( 5 )   378 - 379   2015.5

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  • 自殺類似行動を伴うせん妄に対してミルタザピンが奏効した老年期うつ病の1症例

    長濱 道治, 松田 泰行, 三木 啓之, 田中 一平, 三浦 章子, 金山 三紗子, 山下 智子, 河野 公範, 古屋 智英, 林田 麻衣子, 岡崎 四方, 和氣 玲, 橋岡 禎征, 宮岡 剛, 堀口 淳

    老年精神医学雑誌   26 ( 増刊II )   153 - 153   2015.5

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  • 生活問題と自殺率との関連 疫学的調査に基づいた考察(Correlation of life problems with suicide rate: A discussion based on an epidemiological investigation)

    Inoue Ken, Fukunaga Tatsushige, Masaki Mina, Iida Tadayuki, Wakatsuki Toru, Miyaoka Tsuyoshi, Hashioka Sadayuki, Wake Rei, Tanaka Ippei, Fujita Yoshitsugu, Takeshita Haruo, Fujita Yasuyuki, Horiguchi Jun, Okazaki Yuji

    聖マリアンナ医学研究誌   15   40 - 43   2015.3

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    Language:English   Publisher:(一財)聖マリアンナ会聖マリアンナ医学研究所  

    自殺率と経済的問題などの生活問題との関係について検討するため、1990〜2009年に東京の百貨店で販売された商品券の額と年間自殺率との関係を調べ、統計的解析を行なった。百貨店で販売された商品券の額と自殺率には負の相関が見られ、相関係数は-0.771であった。商品券の販売額は、自殺率変化の指標になり得ることが示された。商品券の額は、社会の経済状態を反映し、人々の生活に影響することから、商品券の販売額と自殺率との間に相関が見られたと考えられた。

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  • Yokukansan increases serum Brain-derived neurotrophic factor (BDNF) levels in Gunn rat

    Furuya Motohide, Miyaoka Tsuyoshi, Hashioka Sadayuki, Wake Rei, Tsuchie Keiko, Horiguchi Jun

    Journal of brain science   44   34 - 41   2014.12

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    Brain-derived neurotrophic factor (BDNF) is expressed at high levels in the hippocampal dentate gyrus (DG), and decreased levels of BDNF have been implicated in the pathophysiology of schizophrenia (SCZ). We have previously reported that yokukansan (YKS), which is a traditional Japanese medicine, is effective for SCZ and promotes neurogenesis in the DG of Gunn rats, an animal model of SCZ. In this study, we investigated the effect of YKS on serum BDNF levels in Gunn rats. The results showed that YKS increased serum BDNF in this model, which may suggest that BDNF expression in the DG leads to increased neurogenesis. Our findings may help to explain the efficacy of YKS in treating SCZ.

    CiNii Books

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  • 不眠を伴う精神疾患に対するラメルテオンの併用投与による(非)ベンゾジアゼピン系睡眠薬の減量効果 2年間長期併用投与の検討

    堀口 淳, 荒木 智子, 矢野 誠子, 安田 英彰, 岡崎 四方, 林田 麻衣子, 長濱 道治, 河野 公範, 三浦 章子, 金山 三紗子, 古屋 智英, 田中 一平, 山下 智子, 和氣 玲, 橋岡 禎征, 宮岡 剛

    医学と薬学   71 ( 7 )   1209 - 1215   2014.6

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    不眠を伴う精神疾患に対するラメルテオンの併用投与による(非)ベンゾジアゼピン系睡眠薬の減量効果について検討した。(非)ベンゾジアゼピン系睡眠薬を服用中で、(非)ベンゾジアゼピン系睡眠薬を減量ないし中止する目的で新たにラメルテオンを追加投与し、その後6ヵ月間以上継続投与した66例を対象とした。最終時に66例中24例が(非)ベンゾジアゼピン系睡眠薬を減量ないし中止ができ、そのうち8例が中止できた。(非)ベンゾジアゼピン系睡眠薬の平均ジアゼパム換算値(ジアゼパム5mg錠数換算値)は、減量群では2.54錠相当から0.8錠相当へと、約3分の1の減量が達成でき、有意差を認めた。ラメルテオン減量群および中止群と非減量群における7つの睡眠の評価項目のいずれの項目も、最終時と比較して、すべての項目で有意に改善した。ふらつきや転倒、反跳性不眠などの副作用が問題になって投与を中止した症例は認めなかった。

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  • 治療抵抗性統合失調症に対する抑肝散の有用性に関する二重盲検試験

    宮岡 剛, 堀口 淳, 遠山 正彌, 澤 芳樹, 大門 貴志, 名井 陽, 江副 幸子, 森 則夫, 三辺 義雄, 伊豫 雅臣, 上野 修一, 古屋 智英, 和氣 玲, 橋岡 禎征

    精神神経学雑誌   ( 2013特別 )   S - 515   2013.5

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  • The effect of atypical antipsychotic drugs on the production of proinflammatory cytokines, nitric oxide and reactive oxygen species by activated microglia

    Takahiro Kato, Sadayuki Hashioka, Akira Monji, Yasukawa Keiji, Shigenobu Kanba

    JOURNAL OF NEUROIMMUNOLOGY   178   180 - 180   2006.9

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    Web of Science

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  • ホスファチジルセリンのリポソームはミクログリアの神経毒分子の産生を抑える(Phosphatidylserine-liposomes inhibit microglial production of neurotoxic molecules)

    橋岡 禎征, 韓 連煕, 加藤 隆弘, 門司 晃, 内海 英雄, 澤田 誠, 神庭 重信, 中西 博

    神経化学   44 ( 2-3 )   205 - 205   2005.8

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Presentations

  • 海馬硬化を伴う内側側頭葉てんかんと診断し神経心理学的評価を行った一例

    菅野猛, 山田仁子, 中尾由美子, 髙崎英気, 橋岡禎征

    北海道精神神経学会 

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    Event date: 2023.12

    Language:Japanese   Presentation type:Oral presentation (general)  

  • 病初期にカプグラ症状が認められたレビー小体型認知症の一例

    今西紗緒里, 吉原慎佑, 今健太郎, 市川香織, 安田麻美, 吉澤門土, 髙崎英気, 田村義之, 橋岡禎征

    北海道精神神経学会第142回例会 

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    Event date: 2022.12

    Language:Japanese   Presentation type:Oral presentation (general)  

  • 統合失調症様の精神症状を呈したてんかん発作後精神病の一例

    今健太郎, 髙崎英気, 今西紗緒里, 市川香織, 安田麻美, 吉原慎佑, 吉澤門土, 田村義之, 橋岡禎征

    北海道精神神経学会第142回例会 

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    Event date: 2022.12

    Language:Japanese   Presentation type:Oral presentation (general)  

  • 精神・神経疾患におけるグリアの 新規治療標的としての可能性

    橋岡禎征

    北海道精神神経学会第141回例会 

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    Event date: 2022.7

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  • グリアに着目したECTの治療効果発現 メカニズムの解明

    橋岡禎征

    第118回日本精神神経学会学術総会 

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    Event date: 2022.6

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

Awards

  • The 14th International College of Geriatric psychoneuropharmacology Best Poster Award

    2014.10   国際老年精神神経薬理学会  

    Sadayuki Hashioka

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    Award type:Award from international society, conference, symposium, etc.  Country:Japan

  • Best Poster Award

    2014.10   International College of Geriatric Psychoneuropharmacology  

    Sadayuki Hashioka

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  • The 11th International Conference on Alzheimer's Disease 2008 Travel Award

    2008.8   国際アルツハイマー病学会  

    Sadayuki Hashioka

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    Award type:Award from international society, conference, symposium, etc.  Country:United States

  • Travel Award

    2008.8   International Conference on Alzheimer's Disease  

    Sadayuki Hashioka

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Research Projects

  • Comprehensive elucidation of anti-neuroinflammatory effects of electroconvulsive treatment

    Grant number:23K24260  2024.4 - 2026.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Grant amount:\6,370,000 ( Direct Cost: \4,900,000 、 Indirect Cost:\1,470,000 )

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  • レビー小体型認知症における中核症状の該当数と指標的バイオマーカーの陽性数との相関

    2023.2

  • 統合失調症と睡眠時無呼吸の関連と睡眠呼吸障害治療による精神症状改善効果の検討

    2022.10

    基盤研究(C)

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    統合失調症患者では肥満の割合が高く、肥満の要因として抗精神病薬の影響などが指摘されている。肥満は閉塞性睡眠時無呼吸(OSA)の最大のリスク因子であり、睡眠薬などのベンゾジアゼピン系薬剤もOSAを悪化させることが知られている。本研究では、統合失調症患者におけるOSAの有病率、OSAのリスク因子、および、OSAが統合失調症の精神症状や認知機能に与える影響を明らかにする。また、OSAの一般的スクリーニングツールであるSTOP-Bangテストなどの統合失調症患者における妥当性を検証し、睡眠呼吸障害治療(CPAP)による精神症状や認知機能の改善効果とCPAPのアドヒアランスを明らかにする。

  • 電気けいれん療法の抗神経炎症作用の包括的解明

    2022.4

    基盤研究(B)

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    本研究はECT(electroconvulsive treatment)の作用機序を抗神経炎症作用の観点から解明することを目的とし、神経炎症モデルラットを用いた基礎研究と、MRS(magnetic resonance spectroscopy)を用いた臨床研究の両面からECTの抗神経炎症作用を包括的に検証する。その成果により、現存の薬物療法とは本質的に作用機序の異なる抗神経炎症作用に基づいた、薬剤抵抗性うつ病の新規治療法の開発をめざしたい。

  • Comprehensive elucidation of anti-neuroinflammatory effects of electroconvulsive treatment

    Grant number:22H02999  2022.4 - 2026.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Grant amount:\17,420,000 ( Direct Cost: \13,400,000 、 Indirect Cost:\4,020,000 )

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  • The relationship between schizophrenia and sleep apnea and the effect of sleep-disordered breathing on improving psychiatric symptoms by treatment of sleep-disordered breathing

    Grant number:21K07537  2021.4 - 2024.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Tamura Yoshiyuki

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    Grant amount:\4,290,000 ( Direct Cost: \3,300,000 、 Indirect Cost:\990,000 )

    We performed video polysomnography to determine a predictable index for the severity of REM sleep behavior disorder (RBD) and the severity of the physical movement episodes. RBD episodes (RBDEs) in patients with RBD were classified according to their severity into the following three motor events (MEs): ME 1; small movements or thrusts; ME 2; proximal movements including violent acts; ME 3; axial movements including bed falls. For each ME, the number of MEs that were preceded by both RWA (REM sleep without Atonia) and REM sleep in the 10 seconds immediately preceding the onset of ME and the number of MEs that were not preceded by both RWA and REM sleep were measured. In severe RBDE (ME 3), the number of MEs preceded by both RWA and REMs was significantly higher than that of MEs not preceded by both (0.8 vs. 0.2, P = 0.033). This was not the case for mild RBDE (ME 1) and moderate RBDE (ME 2). Our results suggest that both RWA and REMs are associated with the development of severe RBDE.

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  • 電気けいれん療法の治療効果メカニズムにおけるグリア血管複合体の関与

    2019.4

    基盤研究(C)

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    電気けいれん療法(ECT; electroconvulsive therapy)は、薬物抵抗性・難治性の精神疾患に有効な身体療法であるが、その効果発現メカニズムは未解明である。そのメカニズム解明をグリア血管複合体の観点から試みた。血液脳関門としての重要な機能を担っている水イオンチャネルであるAQP(aquaporin)4の発現レベル、および脳血管内皮細胞間におけるタイトジャンクション因子claudin-5の発現レベルは、共にECTによって有意に増加することを明らかにした。これらの結果から、ECTの効果発現メカニズムとして、グリア血管複合体の動態変化による血液脳関門の機能調節が関与している可能性が示唆された。

  • Comparative Study on the Issues of Nuclear Global Disasters from the Viewpoint of Life, Livelihood and Mind

    Grant number:19H04355  2019.4 - 2023.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Kawano Noriyuki

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    Grant amount:\16,380,000 ( Direct Cost: \12,600,000 、 Indirect Cost:\3,780,000 )

    We researched the nuclear damage in Kazakhstan, the Marshall Islands, and Japan. Regarding Semipalatinsk, continued questionnaire surveys and other research revealed that direct and indirect effects had spread over a wide area around the nuclear test site. The contents of Kazakhstan’s compensation policy were also examined. Animal and other experiments revealed the state of internal radiation exposure. Concerning hibakusha, using newspaper and Hidankyo questionnaire surveys, we found their perspectives and feelings to be complex and multilayered. We also expanded research on the high incidence of myelodysplastic syndrome in hibakusha and discovered a new onset mechanism of hematopoietic tumors. We found that the COVID-19 pandemic aggravated the psychological burden on the socially vulnerable individuals, such as hibakusha. We comparatively examined the contents of the compensation policies for nuclear victims enacted in different states and clarified their (dis)similarities.

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  • Involvement of gliovascular complex in the therapeutic mechanism of electroconvulsive therapy

    Grant number:19K08018  2019.4 - 2022.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    Hashioka Sadayuki

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    Grant amount:\4,420,000 ( Direct Cost: \3,400,000 、 Indirect Cost:\1,020,000 )

    Electroconvulsive therapy (ECT) shows efficacy in drug-resistant psychiatric disorders, although its mechanism of therapeutic action is unknown. We performed ECT on Gunn rats with abnormal gliovascular complex. ECT significantly increased cerebral vascular coverage by astrocytic end feet, which was reduced in the prelimbic area of frontal lobe and the hippocampal CA1 and CA3 regions, improving depression-like behavior in Gunn rats. ECT also significantly increased the expression of AQP4 and claudin5 in the hippocampus. These results suggest that ECT may exert its therapeutic effect by restoring impaired formation of gliovascular complex.

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  • Analysis of glial-neuronal network abnormalities in treatment-resistant schizophrenia

    Grant number:15H04894  2015.4 - 2019.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)  Grant-in-Aid for Scientific Research (B)

    Miyaoka Tsuyoshi, TSUCHIE keiko

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    Grant amount:\17,420,000 ( Direct Cost: \13,400,000 、 Indirect Cost:\4,020,000 )

    We are investigating the relationship between glial activation and schizophrenia. In this study, we investigated the postmortem expression of glial cells in the hippocampal region of brains of patients with schizophrenia using an immunofluorescence technique. As a result, although difficult in many cases, we successfully detected immunoreactivities for Iba-1 and S100-β in the dentate gyrus in the postmortem brains.
    In addition, we compared the sensitivity of the NMDA-antagonist, ketamine to validate the Gunn rat as a schizophrenia model. By inducing ketamine, Gunn rats exhibited acute hyperactivity and PPI deficits which are positive and negative symptoms respectively of schizophrenia.
    Despite its limitations, efforts to document immunohistochemical glial expressions in postmortem brains will provide possible in situ information for the various approaches to using animal models for patients with schizophrenia.

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  • 活性化グリアの観点から試みる電気けいれん療法の効果発現メカニズムの解明

    2015.4 - 2018.3

    基盤研究(C)

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    電気けいれん療法は薬物抵抗性、難治性精神疾患に有効だが、その効果発現メカニズムについては、未だ仮説程度の解明状況である。我々は活性化グリアの観点から、電気けいれん療法の効果発現メカニズムを実験的に解明する試みを行った。Gunnラットに電気けいれんを施行すると、統合失調症様、およびうつ病様の異常行動は改善し、海馬におけるマイクログリオーシス、およびアストロサイトーシスも有意に抑制された。以上の結果より、電気けいれんの治療効果は、活性化ミクログリア、および活性化アストロサイトを抑制することによって発現している可能性が示唆された。

  • Elucidation of therapeutic efficacy mechanism of electroconvulsive therapy from the view point of activated glia

    Grant number:15K09830  2015.4 - 2018.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    HASHIOKA SADAYUKI

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    Grant amount:\4,810,000 ( Direct Cost: \3,700,000 、 Indirect Cost:\1,110,000 )

    Although electroconvulsive therapy (ECT) is regarded as one of the efficient treatments for intractable psychiatric disorders, the mechanism of therapeutic action remains unclear. Gunn rats showed schizophrenia-like behavior and depressive-like behavior. In their hippocampus, we found both microgliosis and astrogliosis. Electroconvulsive shock (ECS), the animal model of ECT, ameliorated schizophrenia-like behavior and depressive-like behavior of Gunn rats and attenuated microgliosis and astrogliosis in the hippocampus of Gunn rats. Accordingly, therapeutic effects of ECT may be exerted, at least in part, by inhibition of glial activation.

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  • 活性化ヒトグリア細胞による神経毒性の研究

    2012.4 - 2015.3

    基盤研究(C)

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    ヒト初代培養グリア細胞を用いて、ヒトグリアの神経毒性を導く炎症性活性化の解析、ならびにその神経毒性を抑制する薬物の同定を行った。ヒストン脱アセチル化酵素阻害剤がインターフェロン-γによって活性化されたアストロサイトの神経毒性を有意に抑制することが明らかになった。またL型カルシウム拮抗剤は活性化アストロサイトのみならず活性化ミクログリアの神経毒性をも有意に抑制することが分かった。これらの薬物は活性化アストロサイト内における炎症性転写因子STAT3の705チロシン残基のリン酸化を抑制することが分かった。この結果、活性化ヒトアストロサイトの神経毒性は、STAT3リン酸化を阻害することによって抑制されることが示唆され、ヒストン脱アセチル化酵素阻害剤およびL型カルシウム拮抗剤が、活性化グリア細胞が病理的に関与している神経変性疾患の治療に応用できる可能性が示唆された。また神経変性疾患の治療薬を開発する上で、STAT3の705チロシン残基が分子標的になり得る可能性も見出された。

  • Study of neurotoxicity of activated human glial cells

    Grant number:24591721  2012.4 - 2015.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    HASHIOKA Sadayuki, MCGEER Patrick L.

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    Grant amount:\5,460,000 ( Direct Cost: \4,200,000 、 Indirect Cost:\1,260,000 )

    Using primary culture of human glial a cells, we studied inflammatory activation processes of glial cells, which induce neurotoxicity, and identified the drugs that inhibited the glial neurotoxicity. The histone deacetylase inhibitor suberoylanilide hydroxamic acid significantly attenuated the neurotoxicity of astrocytes activated by IFN-γ. L-type calcium channel blockers significantly suppressed neurotoxic secretions from activated human astrocytes and microglia. These drugs reduced the STAT3 phosphorylation at the tyrosine-705 residue in the IFN-γ-activated astrocytes.
    These findings suggest that neurotoxicity of human astrocytes is mediated by STAT3 phosphorylationboth and that both histone deacetylase inhibitors and L-type calcium channel blockers could be a useful treatment option for a broad spectrum of neurodegenerative diseases. Moreover, the tyrosine-705 residue in STAT3 could be a molecular target to develop new drugs for treatment of neurodegenerative disorders.

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  • 活性化グリアによる神経炎症に基づいた精神・神経疾患の病態解明 International coauthorship

    2003.4

    共同研究 

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  • 白菊会総会公開講座講師

    2023.6

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    2021.3

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    2018.11

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    2017.9 - 2022.3

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  • Frontiers in Neuroscience誌 副編集長 International contribution

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