Updated on 2026/03/11

写真a

 
FUJITA Yasuyuki
 
Organization
School of Medicine Medical Course Clinical Medicine Dermatology
Contact information
メールアドレス
Homepage
https://dermat.asahikawa-med.ac.jp/
External link

Degree

  • Ph.D. ( 2010.12   Hokkaido University )

Research Interests

  • 表皮水疱症

  • 細胞治療

Research Areas

  • Life Science / Dermatology

Education

  • Hokkaido University   Graduate School of Medicine

    2006.4 - 2010.12

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  • Hokkaido University

    1996.4 - 2002.3

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Research History

  • Asahikawa Medical College   Professor

    2025.5

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    Country：Japan

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  • Sapporo City General Hospital   Dermatology

    2019.4 - 2025.4

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  • Hokkaido University Hospital   Dermatology   Associate Professor

    2015.10 - 2019.3

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  • Hokkaido University Hospital   Dermatology   Assistant Professor

    2011.1 - 2015.9

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Professional Memberships

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Committee Memberships

  • 日本乾癬学会   評議員  

    2025.9   

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  • 日本臨床皮膚科医会   災害対策委員  

    2024.4 - 2025.5   

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    Committee type：Academic society

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  • 日本皮膚病理組織学会   理事  

    2022.4   

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  • 日本臨床皮膚科医会   ブロック理事  

    2020.4 - 2025.4   

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    Committee type：Academic society

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  • 日本研究皮膚科学会   評議員  

    2015.4   

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    Committee type：Academic society

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Papers

  • Cutaneous methotrexate‐related lymphoproliferative disorder mimicking nodular lymphangitis Reviewed International journal

    Yasuyuki Fujita, Norihiro Yoshimoto, Misako Yamaga, Satoko Shimizu

    JDDG: Journal der Deutschen Dermatologischen Gesellschaft   23   218 - 220   2025.2

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    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/ddg.15601

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  • Secukinumab‐induced oral lichen planus in a psoriatic arthritis patient ameliorated after a switch to risankizumab Reviewed

    Yasuyuki Fujita, Tatsuro Sugai, Yuka Maya, Emi Inamura, Yoko Hirano, Satoko Shimizu

    The Journal of Dermatology   2023.6

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    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/1346-8138.16719

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  • Current topics in Epidermolysis bullosa: Pathophysiology and therapeutic challenges. Invited Reviewed International journal

    Ken Natsuga, Satoru Shinkuma, Chao-Kai Hsu, Yasuyuki Fujita, Akira Ishiko, Katsuto Tamai, John A McGrath

    Journal of dermatological science   104 ( 3 )   164 - 176   2021.12

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    Epidermolysis bullosa (EB) is a group of inherited skin and mucosal fragility disorders resulting from mutations in genes encoding basement membrane zone (BMZ) components or proteins that maintain the integrity of BMZ and adjacent keratinocytes. More than 30 years have passed since the first causative gene for EB was identified, and over 40 genes are now known to be responsible for the protean collection of mechanobullous diseases included under the umbrella term of EB. Through the elucidation of disease mechanisms using human skin samples, animal models, and cultured cells, we have now reached the stage of developing more effective therapeutics for EB. This review will initially focus on what is known about blister wound healing in EB, since recent and emerging basic science data are very relevant to clinical translation and therapeutic strategies for patients. We then place these studies in the context of the latest information on gene therapy, read-through therapy, and cell therapy that provide optimism for improved clinical management of people living with EB.

    DOI： 10.1016/j.jdermsci.2021.11.004

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  • Rash after consumption of game meat Reviewed

    Yuka Maya, Yasuyuki Fujita, Fumihiro Kodama, Satoko Shimizu

    BMJ   n508 - n508   2021.3

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    Authorship：Corresponding author   Publishing type：Research paper (scientific journal)   Publisher：BMJ  

    DOI： 10.1136/bmj.n508

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    Other Link： https://syndication.highwire.org/content/doi/10.1136/bmj.n508

  • Intravenous allogeneic multilineage-differentiating stress-enduring cells in adults with dystrophic epidermolysis bullosa: a phase 1/2 open-label study. Reviewed International journal

    Y Fujita, T Nohara, S Takashima, K Natsuga, M Adachi, K Yoshida, S Shinkuma, T Takeichi, H Nakamura, O Wada, M Akiyama, A Ishiko, H Shimizu

    Journal of the European Academy of Dermatology and Venereology : JEADV   2021.3

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    Authorship：Lead author,　Corresponding author   Language：English  

    DOI： 10.1111/jdv.17201

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  • Intravenous Injection of Muse Cells as a Potential Therapeutic Approach for Epidermolysis Bullosa. Reviewed International journal

    Yasuyuki Fujita, Miho Komatsu, San Eun Lee, Yoshihiro Kushida, Chihiro Nakayama-Nishimura, Wakana Matsumura, Shota Takashima, Satoru Shinkuma, Toshifumi Nomura, Naoya Masutomi, Makoto Kawamura, Mari Dezawa, Hiroshi Shimizu

    The Journal of investigative dermatology   141 ( 1 )   198 - 202   2021.1

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.jid.2020.05.092

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  • Cultured Epidermal Autografts from Clinically Revertant Skin as a Potential Wound Treatment for Recessive Dystrophic Epidermolysis Bullosa. Reviewed International journal

    Matsumura W, Fujita Y, Shinkuma S, Suzuki S, Yokoshiki S, Goto H, Hayashi H, Ono K, Inoie M, Takashima S, Nakayama C, Nomura T, Nakamura H, Abe R, Sato N, Shimizu H

    The Journal of investigative dermatology   139 ( 10 )   2115 - 2124   2019.10

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    Inherited skin disorders have been reported recently to have sporadic normal-looking areas, where a portion of the keratinocytes have recovered from causative gene mutations (revertant mosaicism). We observed a case of recessive dystrophic epidermolysis bullosa treated with cultured epidermal autografts (CEAs), whose CEA-grafted site remained epithelized for 16 years. We proved that the CEA product and the grafted area included cells with revertant mosaicism. Based on these findings, we conducted an investigator-initiated clinical trial of CEAs from clinically revertant skin for recessive dystrophic epidermolysis bullosa. The donor sites were analyzed by genetic analysis, immunofluorescence, electron microscopy, and quantification of the reverted mRNA with deep sequencing. The primary endpoint was the ulcer epithelization rate per patient at 4 weeks after the last CEA application. Three patients with recessive dystrophic epidermolysis bullosa with 8 ulcers were enrolled, and the epithelization rate for each patient at the primary endpoint was 87.7%, 100%, and 57.0%, respectively. The clinical effects were found to persist for at least 76 weeks after CEA transplantation. One of the three patients had apparent revertant mosaicism in the donor skin and in the post-transplanted area. CEAs from clinically normal skin are a potentially well-tolerated treatment for recessive dystrophic epidermolysis bullosa.

    DOI： 10.1016/j.jid.2019.03.1155

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  • The development of induced pluripotent stem cell-derived mesenchymal stem/stromal cells from normal human and RDEB epidermal keratinocytes. Reviewed International journal

    Chihiro Nakayama, Yasuyuki Fujita, Wakana Matsumura, Inkin Ujiie, Shota Takashima, Satoru Shinkuma, Toshifumi Nomura, Riichiro Abe, Hiroshi Shimizu

    Journal of dermatological science   91 ( 3 )   301 - 310   2018.9

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Epidermolysis bullosa (EB) is a group of hereditary disorders caused by mutations in the genes encoding structural molecules of the dermal-epidermal junction (DEJ). Cell-based therapies such as allogeneic mesenchymal stem/stromal cell (MSC) transplantation have recently been explored for severe EB types, such as recessive dystrophic EB (RDEB). However, hurdles exist in current MSC-based therapies, such as limited proliferation from a single cell source and limited cell survival due to potential allogenic rejection. OBJECTIVES: We aimed to develop MSCs from keratinocyte-derived induced pluripotent stem cells (iPSCs). METHODS: Keratinocyte-derived iPSCs (KC-iPSCs) of a healthy human and an RDEB patient were cultured with activin A, 6-bromoindirubin-3'-oxime and bone morphogenetic protein 4 to induce mesodermal lineage formation. These induced cells were subjected to immunohistochemical analysis, flow cytometric analysis and RNA microarray analysis in vitro, and were injected subcutaneously and intravenously to wounded immunodeficient mice to assess their wound-healing efficacy. RESULTS: After their induction, KC-iPSC-induced cells were found to be compatible with MSCs. Furthermore, with the subcutaneous and intravenous injection of the KC-iPSC-induced cells into wounded immunodeficient mice, human type VII collagen was detected at the DEJ of epithelized areas. CONCLUSIONS: We successfully established iPSC-derived MSCs from keratinocytes (KC-iPSC-MSCs) of a normal human and an RDEB patient. KC-iPSC-MSCs may have potential in therapies for RDEB.

    DOI： 10.1016/j.jdermsci.2018.06.004

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  • Establishment of integration-free induced pluripotent stem cells from human recessive dystrophic epidermolysis bullosa keratinocytes. Reviewed International journal

    Wakana Matsumura, Yasuyuki Fujita, Chihiro Nakayama, Satoru Shinkuma, Shotaro Suzuki, Toshifumi Nomura, Riichiro Abe, Hiroshi Shimizu

    Journal of dermatological science   89 ( 3 )   263 - 271   2018.3

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Induced pluripotent stem cell (iPSC) technology enables patient-specific pluripotent stem cells to be derived from adult somatic cells without the use of an embryonic cell source. To date, recessive dystrophic epidermolysis bullosa (RDEB)-specific iPSCs have been generated from patients using integrating retroviral vectors. However, vector integration into the host genome can endanger the biosafety and differentiation propensities of iPSCs. Although various integration-free reprogramming systems have been reported, their utility in reprogramming somatic cells from patients remains largely undetermined. OBJECTIVE: Our study aims to establish safe iPSCs from keratinocytes of RDEB patients using non-integration vector. METHOD: We optimized and infected non-integrating Sendai viral vectors to reprogram keratinocytes from healthy volunteers and RDEB patients. RESULTS: Sendai vector infection led to the reproducible generation of genomic modification-free iPSCs from these keratinocytes, which was proved by immunohistochemistry, reverse transcription polymerase chain reaction, methylation assay, teratoma assay and embryoid body formation assay. Furthermore, we confirmed that these iPSCs have the potential to differentiate into dermal fibroblasts and epidermal keratinocytes. CONCLUSION: This is the first report to prove that the Sendai vector system facilitates the reliable reprogramming of patient keratinocytes into transgene-free iPSCs, providing another pluripotent platform for personalized diagnostic and therapeutic approaches to RDEB.

    DOI： 10.1016/j.jdermsci.2017.11.017

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  • Eosinophilic annular erythema is clinically characterized by central pigmentation reflecting basal melanosis: a clinicopathological study of 10 cases Reviewed

    S. Nakazato, Y. Fujita, S. Shinkuma, T. Nomura, H. Shimizu

    JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY   31 ( 11 )   1916 - 1923   2017.11

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/jdv.14350

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  • Renal failure in dogs kept by a man with severe psoriasis Reviewed

    Y. Fujita, K. Hanazono, E. Uchida, T. Kawahata, A. Suto, K. Nakamura, H. Shimizu

    Journal of the European Academy of Dermatology and Venereology   31 ( 4 )   e184 - e185   2017.4

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Blackwell Publishing Ltd  

    DOI： 10.1111/jdv.13908

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  • Altered balance of epidermis-related chemokines in epidermolysis bullosa Reviewed

    Inkin Ujiie, Yasuyuki Fujita, Chihiro Nakayama, Wakana Matsumura, Shotaro Suzuki, Satoru Shinkuma, Toshifumi Nomura, Riichiro Abe, Hiroshi Shimizu

    JOURNAL OF DERMATOLOGICAL SCIENCE   86 ( 1 )   37 - 45   2017.4

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.jdermsci.2016.12.021

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  • Intravascular large B-cell lymphoma疑診例に対して施行したランダム皮膚生検33名の検討 Reviewed

    辻脇 真澄, 藤田 靖幸, 清水 宏

    日本皮膚科学会雑誌   124 ( 7 )   1305 - 1311   2014.6

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    Authorship：Corresponding author   Language：Japanese   Publisher：(公社)日本皮膚科学会  

    DOI： 10.14924/dermatol.124.1305

    CiNii Books

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    Other Link： https://jlc.jst.go.jp/DN/JALC/10036466978?from=CiNii

  • Infantile eczema caused by formula milk. Reviewed International journal

    Takamasa Ito, Wataru Nishie, Yasuyuki Fujita, Riichiro Abe, Hiroshi Shimizu

    Lancet (London, England)   381 ( 9881 )   1958 - 1958   2013.6

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    Language：English   Publisher：9881  

    DOI： 10.1016/S0140-6736(13)60684-4

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  • Bone marrow transplantation restores epidermal basement membrane protein expression and rescues epidermolysis bullosa model mice Reviewed

    Yasuyuki Fujita, Riichiro Abe, Daisuke Inokuma, Mikako Sasaki, Daichi Hoshina, Ken Natsuga, Wataru Nishie, James R. McMillan, Hideki Nakamura, Tadamichi Shimizu, Masashi Akiyama, Daisuke Sawamura, Hiroshi Shimizu

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   107 ( 32 )   14345 - 14350   2010.8

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    Authorship：Lead author   Language：English   Publishing type：Doctoral thesis  

    DOI： 10.1073/pnas.1000044107

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  • Mesenchymal stem cells are recruited into wounded skin and contribute to wound repair by transdifferentiation into multiple skin cell type Reviewed

    Mikako Sasaki, Riichiro Abe, Yasuyuki Fujita, Satomi Ando, Daisuke Inokuma, Hiroshi Shimizu

    JOURNAL OF IMMUNOLOGY   180 ( 4 )   2581 - 2587   2008.2

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    Language：English   Publishing type：Research paper (scientific journal)  

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  • Presence of circulating CCR10+T cells and elevated serum CTACK/CCL27 in the early stage of mycosis fungoides Reviewed

    Y Fujita, R Abe, M Sasaki, A Honda, M Furuichi, Y Asano, O Norisugi, T Shimizu, H Shimizu

    CLINICAL CANCER RESEARCH   12 ( 9 )   2670 - 2675   2006.5

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1158/1078-0432.CCR-05-1513

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  • Ashy dermatosis-like hyperpigmentation limited to the arms: a case associated with osimertinib therapy. Reviewed International journal

    Shin Iinuma, Takahiro Kobayashi, Akemi Ishida-Yamamoto, Yasuyuki Fujita

    Clinical and experimental dermatology   2026.2

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    Authorship：Last author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/ced/llag085

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  • Unusual Periorbital Edematous Erythema: Ixazomib-Induced Histiocytoid Sweet's Syndrome. Reviewed International journal

    Shin Iinuma, Takahiro Kobayashi, Takahiro Nagashima, Akemi Ishida-Yamamoto, Yasuyuki Fujita

    International journal of dermatology   2026.1

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    Authorship：Last author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/ijd.70242

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  • Pemphigus Foliaceus Mimicking Erythema Annulare Centrifugum: A Case Report. Reviewed International journal

    Takahiro Kobayashi, Shin Iinuma, Yasuyuki Fujita

    Cureus   18 ( 1 )   e100813   2026.1

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    Authorship：Last author   Language：English   Publishing type：Research paper (scientific journal)  

    Pemphigus foliaceus (PF) is an autoimmune blistering disease characterized by superficial, easily ruptured blisters that evolve into scaly erosions. Annular and polycyclic morphologies are uncommon in adults and can complicate diagnosis. Here, we describe the case of a 79-year-old woman with pruritic lesions on the trunk, proximal extremities, and face who had initially been treated for psoriasis. Skin examination revealed multiple erythematous annular and polycyclic plaques with central clearing and fine peripheral scaling, without vesicles or bullae. Skin biopsy findings indicated superficial intraepidermal clefting with acantholytic keratinocytes and only scant eosinophils and neutrophils. Direct immunofluorescence (DIF) demonstrated intercellular deposition of IgG and C3 throughout the epidermis. Serological testing confirmed elevated anti-desmoglein 1 and negative anti-desmoglein 3 antibody levels, establishing PF. Prednisolone with adjunctive intravenous immunoglobulin administration led to gradual improvement. Research concerning pediatric PF and erythema annulare-like acantholytic dermatosis supports the view that annular and polycyclic lesions are morphological variants within the PF spectrum. Timely biopsy, DIF, and serological autoantibody testing are key to establishing a diagnosis.

    DOI： 10.7759/cureus.100813

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  • Methylprednisolone-induced immune thrombocytopenia in a patient with severe bullous pemphigoid. Reviewed International journal

    Shin Iinuma, Takahiro Kobayashi, Takahiro Nagashima, Akemi Ishida-Yamamoto, Yasuyuki Fujita

    European journal of dermatology : EJD   35 ( 6 )   533 - 534   2025.12

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    Authorship：Last author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1684/ejd.2025.4982

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  • Successful Treatment With Spesolimab in a Haemodialysis Patient With Acutely Flaring Generalised Pustular Psoriasis Reviewed International journal

    Yasuyuki Fujita, Sota Itamoto, Akihiro Orita, Kunihiro Kawashima, Satoko Shimizu

    JEADV Clinical Practice   2025.12

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/jvc2.70093

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  • Serum Anti-Drug Antibodies in Psoriasis Patients Undergoing Biologic Therapy in Real-World Clinical Practice: A Single-Center Retrospective Study. Reviewed International journal

    Hiroyoshi Nozaki, Masaru Honma, Mari Kishibe, Yasuyuki Fujita

    The Journal of dermatology   52 ( 10 )   1598 - 1602   2025.10

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    Authorship：Last author   Language：English   Publishing type：Research paper (scientific journal)  

    Biologics are essential for treating psoriasis; however, secondary failure, often due to the development of anti-drug antibodies, is a significant concern. This study aimed to evaluate the relationship between secondary failure and the production of anti-drug antibodies in a real-world setting. Serum levels of anti-adalimumab and anti-secukinumab antibodies were measured using a commercial enzyme-linked immunosorbent assay (ELISA) kit. A retrospective analysis was conducted on 85 patients with psoriasis, focusing on cases in which dermatologists identified secondary failure during biologic therapy. In the adalimumab group, eight patients were identified as having secondary failure. Among them, two showed high titers of anti-drug antibodies, and one showed a low titer. In the secukinumab group, four cases were judged to have secondary failure, but none had elevated antibody titers. The results of this study indicate that the mechanisms underlying secondary failure in real-world settings may vary depending on the drug. The secondary failure of adalimumab, a drug with high immunogenicity, is primarily attributed to the production of anti-drug antibodies. In contrast, for secukinumab, which has low immunogenicity, extending the dosing interval may lead to reduced serum drug levels and an increased risk of secondary failure.

    DOI： 10.1111/1346-8138.17894

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  • Erythematous Follicular Papules on the Thighs: A Quiz. Reviewed International journal

    Shin Iinuma, Takahiro Kobayashi, Akemi Ishida-Yamamoto, Yasuyuki Fujita

    Acta dermato-venereologica   105   adv44139   2025.8

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    Authorship：Last author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.2340/actadv.v105.44139

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  • Refractory Post‐Zoster Eosinophilic Dermatitis of the Eyelids Successfully Treated With Mycophenolate Mofetil Reviewed International journal

    Takahiro Hase, Yasuyuki Fujita, Kodai Miyamoto, Satoko Shimizu

    The Journal of Dermatology   2025.8

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    Authorship：Corresponding author   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/1346-8138.17833

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  • 市立札幌病院におけるdermatitis neglectaの臨床的,疫学的検討 Reviewed

    島野 麻由奈, 藤田 靖幸, 山賀 三紗子, 葭本 倫大, 清水 聡子

    臨床皮膚科   79 ( 9 )   689 - 694   2025.8

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    Authorship：Corresponding author   Language：Japanese   Publisher：(株)医学書院  

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  • Microcystic Pseudoglandular Cutaneous Neurofibroma: The First Japanese Case of a Rare Neurofibroma Variant. Reviewed International journal

    Shinichi Nakazato, Yasuyuki Fujita, Takashi Anan

    The Journal of dermatology   52 ( 7 )   e623-e625   2025.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/1346-8138.17761

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  • 【光と関わる皮膚疾患】デュピルマブが奏効した慢性光線性皮膚炎 Invited Reviewed

    織田 晃央, 藤田 靖幸, 板本 想太, 清水 聡子

    皮膚病診療   47 ( 7 )   627 - 631   2025.7

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    Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：(株)協和企画  

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  • 【薬疹】スガマデクスナトリウムによる周術期アナフィラキシーの1例 Reviewed

    丸尾 美帆, 藤田 靖幸, 板本 想太, 織田 晃央, 清水 聡子

    皮膚科の臨床   67 ( 7 )   883 - 886   2025.6

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  • A case of xanthogranuloma that developed in scar tissue following treatment for diffuse large B‐cell lymphoma Reviewed International journal

    Emi Inamura, Yasuyuki Fujita, Yoko Hirano, Mayuna Shimano, Ken Natsuga, Satoshi Yamamoto, Takahiro Tsuji, Satoko Shimizu

    The Journal of Dermatology   2025.4

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    Authorship：Corresponding author   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/1346-8138.17542

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  • Apremilast: a novel intervention for resistant acne conglobata - a case report. Reviewed International journal

    Satoko Shimizu, Emi Inamura, Yoko Hirano, Shunichiro Takezaki, Yasuyuki Fujita

    European journal of dermatology : EJD   35 ( 1 )   47 - 48   2025.2

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    Authorship：Last author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1684/ejd.2025.4812

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  • Kutane methotrexatbedingte lymphoproliferative Erkrankung imitiert noduläre Lymphangitis Reviewed International journal

    Yasuyuki Fujita, Norihiro Yoshimoto, Misako Yamaga, Satoko Shimizu

    JDDG: Journal der Deutschen Dermatologischen Gesellschaft   2025.2

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    Authorship：Lead author,　Corresponding author   Language：German   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/ddg.15601_g

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  • Successful Treatment of Generalized Pustular Psoriasis Following Lower Limb Surgery with Spesolimab: A Case Report Reviewed

    板本想太, 藤田靖幸, 織田晃央, 川嶋邦裕, 清水聡子

    市立札幌病院医誌   84   33 - 38   2025

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    Authorship：Corresponding author   Language：Japanese   Publishing type：Research paper (bulletin of university, research institution)  

    J-GLOBAL

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  • 【予想外の皮膚病(意外な結末となった皮膚病)】アンケート企画 私が経験した予想外の皮膚病 胼胝様の外観をきたしたeccrine angiomatous hamartoma

    藤田 靖幸, 山賀 三紗子, 葭本 倫大, 梅津 修, 清水 聡子

    皮膚病診療   46 ( 10 )   870 - 870   2024.10

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    Authorship：Lead author,　Corresponding author   Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：(株)協和企画  

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  • Morphea-like subcutaneous panniculitis-like T-cell lymphoma. Reviewed International journal

    Keiko Tokuchi, Teruki Yanagi, Emi Inamura, Takuya Kawamura, Takashi Seo, Yasuyuki Fujita, Masao Nakagawa, Ikumi Kasahara, Yoshihiro Matsuno, Hideyuki Ujiie

    JAAD case reports   46   27 - 29   2024.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.jdcr.2023.12.025

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  • Successful treatment of multicentric Castleman's disease associated with dystrophic epidermolysis bullosa using anti-interleukin-6 receptor antibody. Reviewed International journal

    Satsuki Naruse, Shota Takashima, Yasuyuki Fujita, Hiroshi Kataoka, Nobuaki Kawamura, Ken Natsuga, Hideyuki Ujiie

    The Journal of dermatology   51   e268 - e269   2024.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/1346-8138.17172

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  • Two cases of abdominal wall paresis associated with herpes zoster Reviewed

    武石侑杜, 藤田靖幸, 平野瑤子, 稲村衣美, 清水聡子

    市立札幌病院医誌   83   2024

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    J-GLOBAL

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  • 胼胝様の外観をきたしたeccrine angiomatous hamartoma Invited Reviewed

    藤田靖幸, 山賀三紗子, 葭本倫大, 梅津修, 清水聡子

    皮膚病診療   46 ( 10 )   2024

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  • A case of adult-onset Still’s disease complicated by Sjoegren’s syndrome Invited Reviewed

    島野麻由奈, 藤田靖幸, 山賀三紗子, 葭本倫大, 近藤真, 清水聡子

    皮膚病診療   46 ( 9 )   846 - 849   2024

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  • Four cases of creeping disease Reviewed

    山賀三紗子, 藤田靖幸, 葭本倫大, 田中美緒, 丸山治彦, 清水聡子

    市立札幌病院医誌   83   2024

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  • Two cases of neonatal lupus erythematosus Reviewed

    平野瑶子, 藤田靖幸, 稲村衣美, 水上卓哉, 池田雅彦, 佐藤逸美, 清水聡子

    市立札幌病院医誌   82   115 - 119   2023

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  • A case of erythema multiforme after COVID-19 Invited Reviewed

    藤田靖幸, 稲村衣美, 須貝達朗, 清水聡子

    皮膚病診療   45 ( 9 )   764 - 767   2023

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  • Varicella Vaccine-Induced Infantile Zoster-Like Skin Rash Reviewed

    Tatsuro Sugai, Yasuyuki Fujita, Souichi Yamada, Shuetsu Fukushi, Emi Inamura, Kinya Hatakeyama, Satoko Shimizu

    The Journal of Pediatrics   2022.12

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    DOI： 10.1016/j.jpeds.2022.08.032

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  • Loss of epidermal Langerhans cells in psoriasiform lesions of de novo induced or worsened pre‐existing psoriasis following uses of immune checkpoint inhibitors Reviewed

    Misaki Kase, Yasuyuki Fujita, Asako Ota, Satoko Shimizu, Saori Itoi‐Ochi, Shigetoshi Sano

    The Journal of Dermatology   2022.9

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    DOI： 10.1111/1346-8138.16427

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  • Prevalence and patterns of cutaneous manifestations in 1245 COVID‐19 patients in Japan: a single‐centre study Reviewed

    T. Sugai, Y. Fujita, E. Inamura, Y. Maya, S. Shimizu

    Journal of the European Academy of Dermatology and Venereology   36 ( 7 )   2022.7

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    DOI： 10.1111/jdv.18062

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  • Pseudoangiomatous stromal hyperplasia (PASH) arising in an axillary accessory breast. Reviewed International journal

    Yuka Maya, Yasuyuki Fujita, Kodai Miyamoto, Machiko Nishimura, Sari Iwasaki, Satoko Shimizu

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG   2022.2

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    DOI： 10.1111/ddg.14710

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  • New insight of itch mediators and proinflammatory cytokines in epidermolysis bullosa Reviewed

    Hong Ha Nguyen, Satoru Shinkuma, Ryota Hayashi, Tatsuya Katsumi, Tomoki Nishiguchi, Ken Natsuga, Yasuyuki Fujita, Riichiro Abe

    Journal of Cutaneous Immunology and Allergy   5 ( 3 )   78 - 87   2022.2

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    <jats:title>Abstract</jats:title><jats:sec><jats:title>Objectives</jats:title><jats:p>Epidermolysis bullosa (EB) is a hereditary disorder characterized by mechanical stress‐induced blistering. The presence of extracutaneous complications such as cardiomyopathy and renal disease observed in severe EB subtypes and the fact that pruritus is a common symptom across all EB subtypes indicate that EB is not only a skin fragility disease but also a systemic inflammatory disorder. Our study aims to elucidate the basis of the systemic inflammation seen in EB patients.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We analyzed serum samples of 20 EB patients by Luminex bead‐based cytokine assays and enzyme‐linked immunosorbent assays.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The serum levels of sIL‐2R, IL‐6, HGF, M‐CSF, SCGF‐β, IL‐8, IL‐16, IFN‐γ, MIF, MIP‐1α, and thymic stromal lymphopoietin (TSLP) (<jats:italic>p</jats:italic> < .01, <jats:italic>p</jats:italic> < .01, <jats:italic>p</jats:italic> < .01, <jats:italic>p</jats:italic> < .01, <jats:italic>p</jats:italic> < .01, <jats:italic>p</jats:italic> < .05, <jats:italic>p</jats:italic> < .05, <jats:italic>p</jats:italic> < .05, <jats:italic>p</jats:italic> < .05, <jats:italic>p</jats:italic> < .05, and <jats:italic>p</jats:italic> = .01, respectively) were found to be significantly elevated in EB patients, whereas TNF‐β (<jats:italic>p</jats:italic> < .01) was decreased. Th2 cytokines including IL‐4, IL‐5, and IL‐13 were not elevated in EB patients. In contrast, TSLP was significantly increased, and IL‐31 and oncostatin M were not statistically significant but tended to be higher in the patients than in healthy controls. Among proinflammatory cytokines such as IL‐1β, IL‐6, and TNF‐α, IL‐6 was elevated in EB patients.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The imbalance of several itch mediators and proinflammatory cytokines was identified. Biologics targeting the cytokines found to be elevated in the sera of patients is considered as a beneficial treatment option for EB.</jats:p></jats:sec>

    DOI： 10.1002/cia2.12230

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  • A case of refractory neutrophilic urticaria with MEFV gene mutation Reviewed

    稲村衣美, 藤田靖幸, 須貝達朗, 冨田智子, 清水聡子

    市立札幌病院医誌   81 ( 1 )   2022

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  • 表皮の付属器分化を伴った皮膚線維腫の検討 Reviewed

    水上卓哉, 藤田靖幸, 真屋由佳, 清水聡子

    皮膚科の臨床   64 ( 3 )   2022

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  • Cutaneous sarcoidosis with aggregated comedones in a young woman possibly associated with cosmetic laser treatment. Reviewed International journal

    Yuka Maya, Yasuyuki Fujita, Takuya Mizukami, Sari Iwasaki, Satoko Shimizu

    The Journal of dermatology   48 ( 12 )   e589-e590   2021.12

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    DOI： 10.1111/1346-8138.16150

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  • Neutrophils initiate and exacerbate Stevens-Johnson syndrome and toxic epidermal necrolysis. Reviewed International journal

    Manao Kinoshita, Youichi Ogawa, Natsumi Hama, Inkin Ujiie, Akito Hasegawa, Saeko Nakajima, Takashi Nomura, Jun Adachi, Takuya Sato, Schuichi Koizumi, Shinji Shimada, Yasuyuki Fujita, Hayato Takahashi, Yoshiko Mizukawa, Takeshi Tomonaga, Keisuke Nagao, Riichiro Abe, Tatsuyoshi Kawamura

    Science translational medicine   13 ( 600 )   2021.6

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    Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening mucocutaneous adverse drug reactions characterized by massive epidermal detachment. Cytotoxic T cells and associated effector molecules are known to drive SJS/TEN pathophysiology, but the contribution of innate immune responses is not well understood. We describe a mechanism by which neutrophils triggered inflammation during early phases of SJS/TEN. Skin-infiltrating CD8+ T cells produced lipocalin-2 in a drug-specific manner, which triggered the formation of neutrophil extracellular traps (NETs) in early lesional skin. Neutrophils undergoing NETosis released LL-37, an antimicrobial peptide, which induced formyl peptide receptor 1 (FPR1) expression by keratinocytes. FPR1 expression caused keratinocytes to be vulnerable to necroptosis that caused further release of LL-37 by necroptotic keratinocytes and induced FPR1 expression on surrounding keratinocytes, which likely amplified the necroptotic response. The NETs-necroptosis axis was not observed in less severe cutaneous adverse drug reactions, autoimmune diseases, or neutrophil-associated disorders, suggesting that this was a process specific to SJS/TEN. Initiation and progression of SJS/TEN keratinocyte necroptosis appear to involve a cascade of events mediated by innate and adaptive immune responses, and understanding these responses may contribute to the identification of diagnostic markers or therapeutic targets for these adverse drug reactions.

    DOI： 10.1126/scitranslmed.aax2398

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  • Altered replication stress response due to CARD14 mutations promotes recombination-induced revertant mosaicism. Reviewed International journal

    Toshinari Miyauchi, Shotaro Suzuki, Masae Takeda, Jin Teng Peh, Masayuki Aiba, Ken Natsuga, Yasuyuki Fujita, Takuya Takeichi, Taiko Sakamoto, Masashi Akiyama, Hiroshi Shimizu, Toshifumi Nomura

    American journal of human genetics   108 ( 6 )   1026 - 1039   2021.6

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    Revertant mosaicism, or "natural gene therapy," refers to the spontaneous in vivo reversion of an inherited mutation in a somatic cell. Only approximately 50 human genetic disorders exhibit revertant mosaicism, implicating a distinctive role played by mutant proteins in somatic correction of a pathogenic germline mutation. However, the process by which mutant proteins induce somatic genetic reversion in these diseases remains unknown. Here we show that heterozygous pathogenic CARD14 mutations causing autoinflammatory skin diseases, including psoriasis and pityriasis rubra pilaris, are repaired mainly via homologous recombination. Rather than altering the DNA damage response to exogenous stimuli, such as X-irradiation or etoposide treatment, mutant CARD14 increased DNA double-strand breaks under conditions of replication stress. Furthermore, mutant CARD14 suppressed new origin firings without promoting crossover events in the replication stress state. Together, these results suggest that mutant CARD14 alters the replication stress response and preferentially drives break-induced replication (BIR), which is generally suppressed in eukaryotes. Our results highlight the involvement of BIR in reversion events, thus revealing a previously undescribed role of BIR that could potentially be exploited to develop therapeutics for currently intractable genetic diseases.

    DOI： 10.1016/j.ajhg.2021.04.021

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  • A Nodule on a Woman's Umbilicus. Reviewed International journal

    Yuka Maya, Yasuyuki Fujita, Takuya Mizukami, Satoko Shimizu

    The American journal of medicine   134 ( 5 )   e331-e332   2021.5

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    DOI： 10.1016/j.amjmed.2020.09.061

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  • Cutaneous incidentaloma revealed by [18F]-FDG-PET/CT Reviewed

    Y. Maya, Y. Fujita, T. Mizukami, T. Takei, S. Shimizu

    Journal of the European Academy of Dermatology and Venereology   35 ( 4 )   e261 - e263   2021.4

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    DOI： 10.1111/jdv.16992

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  • Serum Krebs von den Lungen-6 levels in psoriatic patients under treatment with biologics. Reviewed International journal

    Hiroaki Iwata, Naoya Haga, Tatsuro Sugai, Yasuyuki Fujita

    The Journal of dermatology   48 ( 3 )   376 - 379   2021.3

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    During biologic treatments, attention should be paid to adverse reactions, particularly infectious diseases. Furthermore, drug-induced interstitial lung disease is also known to be associated with biologic therapies. We retrospectively reviewed serum Krebs von den Lungen-6 (KL-6) levels in psoriatic patients who underwent treatment with seven different biologics. A total of 67 patients who received 80 biologic treatments were evaluated. The 31 anti-tumor necrosis factor (TNF)-α treatments consisted of 17 infliximab (IFX) and 14 adalimumab. The 23 anti-interleukin (IL)-23 treatments consisted of 14 ustekinumab and nine guselkumab. The 26 anti-IL-17 treatments consisted of nine secukinumab, six ixekizumab and 11 brodalumab. The IFX showed significantly increased mean serum KL-6 (170.9%), but none of the other treatments showed significant increases. Thirteen of the 17 (75.6%) patients in the IFX and 17 of the 31 (54.8%) patients in the total anti-TNF-α group demonstrated at least a 25% increase in serum KL-6. Levels exceeding the cut-off (500 U/mL) were detected in three patients before treatment and in seven patients after treatment. This study showed that anti-IL-17 and anti-IL-23 treatments have no significant impact on serum KL-6 level. In addition to the influence of IFX, a significantly large number of patients in the IFX group had a history of methotrexate administration associated with psoriatic arthritis, which might have influenced the KL-6 level. None of the patients with elevated serum KL-6 showed pulmonary changes by computed tomography and/or X ray.

    DOI： 10.1111/1346-8138.15665

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  • Calcinosis cutis in self-healing dominant dystrophic epidermolysis bullosa. Reviewed International journal

    Shota Takashima, Yasuyuki Fujita, Satoru Shinkuma, Satoko Shimizu, Tomoka Hasegawa, Norio Amizuka, Hiroshi Shimizu, Ken Natsuga

    The Journal of dermatology   47 ( 12 )   e457-e458   2020.12

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  • Multiple Nodules Arising within a Birthmark on the Scalp: A Quiz. Reviewed International journal

    Takuya Mizukami, Yasuyuki Fujita, Yuka Maya, Kunihiro Kawashima, Takahiro Tsuji, Eiichi Arai, Koichi Honma, Satoko Shimizu

    Acta dermato-venereologica   100 ( 14 )   adv00206   2020.7

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    DOI： 10.2340/00015555-3564

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  • Vitamin B12 allergy manifesting as lymphomatoid contact dermatitis. Reviewed International journal

    Yasuyuki Fujita, Takuya Mizukami, Yuka Maya, Reine Moriuchi, Sari Iwasaki, Yuichiro Fukasawa, Akihiko Shibaki, Satoko Shimizu

    European journal of dermatology : EJD   30 ( 3 )   304 - 305   2020.6

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    DOI： 10.1684/ejd.2020.3786

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  • Safety and Efficacy of the Sirolimus Gel for TSC Patients With Facial Skin Lesions in a Long-Term, Open-Label, Extension, Uncontrolled Clinical Trial. Reviewed International journal

    Mari Wataya-Kaneda, Hiroshi Nagai, Yuuki Ohno, Hiroo Yokozeki, Yasuyuki Fujita, Hironori Niizeki, Kazue Yoshida, Masaaki Ogai, Yuichi Yoshida, Akihiko Asahina, Kazuyoshi Fukai, Chiharu Tateishi, Izumi Hamada, Tatsuro Takahata, Kenji Shimizu, Shigeki Shimasaki, Hiroyuki Murota

    Dermatology and therapy   10 ( 4 )   635 - 650   2020.5

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    INTRODUCTION: Our previous clinical studies have demonstrated the short-term efficacy and safety of the sirolimus gel for patients with tuberous sclerosis complex (TSC). However, long-term clinical evidence is lacking. Our objective was to assess the safety and efficacy of long-term treatment with the sirolimus gel for the skin lesions of TSC patients. METHODS: We conducted a multicenter, open-label, uncontrolled clinical trial in 94 Japanese patients with TSC. Patients applied the 0.2% sirolimus gel on their face or head twice daily for > 52 weeks (maximum 136 weeks for safety). The safety endpoints were the rate of adverse event (AE)-caused discontinuation (primary endpoint) and the incidence of AEs. The efficacy endpoint was the response rate of angiofibromas, cephalic plaques, and hypomelanotic macules. RESULTS: Among 94 enrolled patients (mean age, 21 years; range 3-53 years), the rate of AE-caused discontinuation was 2.1% (2/94 patients). Although application site irritation and dry skin occurred relatively frequently, none of the drug-related AEs were serious; most of the drug-related AEs resolved rapidly. The major drug-related AEs (≥ 5% in incidence) were application site irritation (30.9%), dry skin (27.7%), acne (20.2%), eye irritation (8.5%), pruritus (8.5%), erythema (7.4%), dermatitis acneiform (6.4%), and dermatitis contact (5.3%). The response rates of angiofibromas, cephalic plaques, and hypomelanotic macules were 78.2% [95% confidence interval (CI) 68.0-86.3%], 66.7% (95% CI 51.1-80.0%), and 72.2% (95% CI 46.5-90.3%), respectively. CONCLUSIONS: The gel was well tolerated for a long time by patients with TSC involving facial skin lesions and continued to be effective. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT02634931.

    DOI： 10.1007/s13555-020-00387-7

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  • Refractory juvenile psoriatic uveitis without arthritis: a literature review Reviewed

    H. Miyazawa, Y. Fujita, K. Muramatsu, H. Iwata, T. Nomura, K. Namba, D. Hoshina, H. Shimizu

    Journal of the European Academy of Dermatology and Venereology   34 ( 4 )   e173 - e175   2020.4

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    DOI： 10.1111/jdv.16127

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  • Pancreatic panniculitis and polyarthritis accompanied by the exacerbation of pancreatic carcinoma Reviewed

    宮本航大, 藤田靖幸, 真屋由佳, 中村路夫, 清水聡子

    市立札幌病院医誌   80 ( 1 )   2020

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  • 【4疾患からみる膠原病のいま】小児線状強皮症に対してシクロスポリン内服が有効であった2例 Reviewed

    眞井 翔子, 藤田 靖幸, 夏賀 健, 西江 渉, 小野寺 智洋, 岡 敏明, 清水 宏

    皮膚科の臨床   61 ( 12 )   1797 - 1802   2019.11

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  • Electron Microscopic and Immunohistochemical Findings of the Epidermal Basement Membrane in Two Families with Nail-patella Syndrome. Reviewed International journal

    Shinkuma S, Nakamura H, Maehara M, Takashima S, Nomura T, Fujita Y, Hasegawa S, Sato-Matsumura KC, Abe R, Shimizu H

    Acta dermato-venereologica   99 ( 12 )   1110 - 1115   2019.9

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    Nail-patella syndrome is an autosomal dominant disorder characterized by nail dysplasia and skeletal anomaly. Some patients have been shown to have ultrastructural abnormalities of the glomerular basement membrane that result in nephrosis. However, little has been reported on the epidermal basement membrane in this condition. This paper reports 2 families with nail-patella syndrome. Direct sequencing analysis of LMX1B revealed that family 1 and family 2 were heterozygous for the mutations c.140-1G>C and c.326+1G>C, respectively. To evaluate the epidermal basement membrane zone, ultrastructural and immunohistochemical analyses were performed using skin specimens obtained from the dorsal thumb. Electron microscopy showed intact hemidesmosomes, lamina lucida, lamina densa, and anchoring fibrils. Immunofluorescence studies with antibodies against components of the epidermal basement membrane zone revealed a normal expression pattern among the components, including type IV collagen. These data suggest that nail dysplasia in patients with nail-patella syndrome is not caused by structural abnormalities of the epidermal basement membrane.

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  • Erythema multiforme-like hypersensitivity reaction to infliximab: an atypical and refractory case. Reviewed International journal

    Takuya Mizukami, Yasuyuki Fujita, Shoko Mai, Hajime Miyazawa, Toshinari Miyauchi, Ken Muramatsu, Takehiko Katsurada, Hitoshi Kobayashi, Hiroshi Shimizu

    European journal of dermatology : EJD   29 ( 3 )   334 - 336   2019.6

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    DOI： 10.1684/ejd.2019.3548

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  • Refractory oral ulcers in eosinophilic granulomatosis with polyangiitis. Reviewed International journal

    Otsuka T, Iwata H, Kosumi H, Muramatsu K, Ito T, Tsujiwaki M, Fujita Y, Kamaguchi M, Kitagawa Y, Shimizu H

    The Journal of dermatology   46 ( 10 )   e377-e378   2019.5

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  • Severe Septic Vasculitis Preceding Thoracic Empyema: Staphylococcus aureus Enterotoxin Deposition in Vessel Walls as a Possible Pathomechanism. Reviewed International journal

    Yasuyuki Yamaguchi, Yasuyuki Fujita, Tetsuya Ikeda, Yosuke Mai, Hajime Miyazawa, Wakana Matsumura, Toshifumi Nomura, Hiroshi Shimizu

    Acta dermato-venereologica   99 ( 4 )   464 - 465   2019.4

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    DOI： 10.2340/00015555-3122

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  • Loss-of-function mutation in DSG1 underlies focal palmoplantar keratoderma Reviewed

    T. Nomura, M. Takeda, J. T. Peh, T. Miyauchi, S. Suzuki, Y. Fujita, T. Uesugi, H. Shimizu

    Journal of the European Academy of Dermatology and Venereology   33 ( 3 )   e137 - e138   2019.3

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    DOI： 10.1111/jdv.15349

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  • A Nodular Lesion of the Foot Detected by 18F-FDG PET/CT in Mycosis Fungoides: A Plantar Wart. Reviewed International journal

    Yasuyuki Fujita, Ken Natsuga, Osamu Manabe, Kenji Hirata, Hiroshi Shimizu

    Clinical nuclear medicine   44 ( 3 )   244 - 245   2019.3

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    A 34-year-old Japanese woman presented with widespread scaly erythema that had enlarged over 2 years. A skin biopsy revealed the diagnosis of mycosis fungoides (patch stage, T1b N0 M0 B0), a most frequent cutaneous T-cell lymphoma. F-FDG PET/CT scan unexpectedly showed intense uptake on the left sole, which suggested a tumorous mycosis fungoides lesion (SUVmax = 6.2). Careful examination revealed the mass to be a typical plantar wart of 2 cm in diameter that the patient had not recognized. With repeated cryotherapy, the wart disappeared in 6 months, and follow-up F-FDG PET/CT showed no abnormal uptake on the left sole.

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  • Image Gallery: Multiple localized lipoatrophy in recessive dystrophic epidermolysis bullosa. Reviewed International journal

    T Nohara, Y Fujita, S Takashima, K Natsuga, H Shimizu

    The British journal of dermatology   180 ( 3 )   e64   2019.3

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    DOI： 10.1111/bjd.17356

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  • Efficient gene reframing therapy for recessive dystrophic epidermolysis bullosa using CRISPR/Cas9. Reviewed International journal

    Takashima S, Shinkuma S, Fujita Y, Nomura T, Ujiie H, Natsuga K, Iwata H, Nakamura H, Vorobyev A, Abe R, Shimizu H

    The Journal of investigative dermatology   139 ( 8 )   1711 - 1721   2019.3

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    The clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 system induces site-specific double-strand breaks, which stimulate cellular DNA repair through either the homologous recombination or non-homologous end-joining pathways. The non-homologous end-joining pathway, which is activated more frequently than homologous recombination, is prone to introducing small insertions and/or deletions at the double-strand break site, leading to changes in the reading frame. We hypothesized that the non-homologous end-joining pathway is applicable to genetic diseases caused by a frameshift mutation through restoration of the reading frame. Recessive dystrophic epidermolysis bullosa is a hereditary skin disorder caused by mutations in COL7A1. In this study, we applied gene reframing therapy to a recurrent frameshift mutation, c.5819delC, in COL7A1, which results in a premature termination codon. CRISPR/Cas9 targeting this specific mutation site was delivered to recessive dystrophic epidermolysis bullosa patient fibroblasts. After genotyping a large collection of gene-edited fibroblast clones, we identified a significant number (17/50) of clones in which the frameshift in COL7A1 was restored. The reframed COL7 was functional, as shown by triple-helix formation assay in vitro, and was correctly distributed in the basement membrane zone in mice. Our data suggest that mutation site-specific non-homologous end-joining might be a highly efficient gene therapy for inherited disorders caused by frameshift mutations.

    DOI： 10.1016/j.jid.2019.02.015

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  • Somatic recombination underlies frequent revertant mosaicism in loricrin keratoderma. Reviewed International journal

    Suzuki S, Nomura T, Miyauchi T, Takeda M, Fujita Y, Nishie W, Akiyama M, Ishida-Yamamoto A, Shimizu H

    Life science alliance   2 ( 1 )   2019.2

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    Revertant mosaicism is a phenomenon in which pathogenic mutations are rescued by somatic events, representing a form of natural gene therapy. Here, we report on the first evidence for revertant mosaicism in loricrin keratoderma (LK), an autosomal dominant form of ichthyosis caused by mutations in LOR on 1q21.3. We identified two unrelated LK families exhibiting dozens of previously unreported white spots, which increased in both number and size with age. Biopsies of these spots revealed that they had normal histology and that causal LOR mutations were lost. Notably, dense single nucleotide polymorphism mapping identified independent copy-neutral loss-of-heterozygosity events on chromosome 1q extending from regions centromeric to LOR to the telomere in all investigated spots, suggesting that somatic recombination represents a common reversion mechanism in LK. Furthermore, we demonstrated that reversion of LOR mutations confers a growth advantage to cells in vitro, but the clinically limited size of revertant spots suggests the existence of mechanisms constraining revertant clone expansion. Nevertheless, the identification of revertant mosaicism in LK might pave the way for revertant therapy for this intractable disease.

    DOI： 10.26508/lsa.201800284

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  • Proliferative nodules arising within a mid-sized congenital melanocytic nevus in adulthood Reviewed

    水上卓哉, 藤田靖幸, 真屋由佳, 川嶋邦裕, 辻隆裕, 新井栄一, 本間光一, 清水聡子

    市立札幌病院医誌   79 ( 1 )   2019

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  • Compound heterozygous missense mutations p.Leu207Pro and p.Tyr544Cys in TGM1 cause a severe form of lamellar ichthyosis Reviewed International journal

    Masae Takeda, Toshifumi Nomura, Takato Sugiyama, Toshinari Miyauchi, Shotaro Suzuki, Yasuyuki Fujita, Hiroshi Shimizu

    The Journal of Dermatology   45 ( 12 )   1463 - 1467   2018.12

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    TGM1 is the most common gene responsible for lamellar ichthyosis. Previous studies have suggested that patients with lamellar ichthyosis carrying two missense mutations in TGM1 show significantly less severe phenotypes than those with at least one truncating mutation in TGM1. Here, we report a patient with severe lamellar ichthyosis who was compound heterozygous for TGM1 missense mutations, including a novel one. A 22-year-old Japanese man presented with large, dark brown, plate-like scales on the extremities and small adherent scales on the face and trunk. His other clinical findings included ectropion, hair loss, hypohidrosis, hyperthermia in summer, palmoplantar keratoderma and constriction of the fingers. Dermoscopy revealed accentuated sulci cutis with numerous large keratotic plugs in the cristae cutis. Histologically, orthohyperkeratosis and mild acanthosis were noted. Electron microscopy showed reduced cornified envelope thickness and numerous lipid droplets in the stratum corneum. Mutation analysis revealed the patient to be compound heterozygous for missense mutations, c.620T>C (p.Leu207Pro) and c.1631A>G (p.Tyr544Cys), in TGM1. Furthermore, we showed that TGM1 enzymatic activity was largely absent in his epidermis. These findings led us to diagnose him as having lamellar ichthyosis. This study has two important notions. First, even two missense mutations in TGM1 can cause severe lamellar ichthyosis. Second, this is the first report of dermoscopic findings of lamellar ichthyosis, implicating the obstruction of sweat glands by keratotic plugs in the pathogenesis of hypohidrosis in the disease. In conclusion, this study provides further insights into genotype-phenotype correlations and pathogenesis in lamellar ichthyosis.

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  • Disseminated Erythematous Papules and Pustules: A Quiz. Reviewed International journal

    Fujita Y, Shiiya C, Inamura-Takashima Y, Nomura T, Shibaki A, Shimizu H

    Acta dermato-venereologica   99 ( 1 )   123 - 124   2018.9

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    DOI： 10.2340/00015555-3024

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  • Novel COL7A1 mutation in a family with bullous dermolysis of the newborn: Phenotypic variability associated with a COL7A1 mutation within the same family. Reviewed International journal

    Shota Takashima, Satoru Shinkuma, Yasuyuki Fujita, Ken Natsuga, Toshifumi Nomura, Tokimasa Hida, Shuku Ishikawa, Hideki Nakamura, Riichiro Abe, Hiroshi Shimizu

    The Journal of dermatology   45 ( 9 )   e260-e261 - e261   2018.9

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  • Detection of anti-BP180 NC16A autoantibodies after the onset of dipeptidyl peptidase-IV inhibitor-associated bullous pemphigoid: a report of three patients. Reviewed

    Mai Y, Nishie W, Izumi K, Yoshimoto N, Morita Y, Watanabe M, Toyonaga E, Ujiie H, Iwata H, Fujita Y, Nomura T, Sato-Matsumura KC, Shimizu S, Shimizu H

    The British journal of dermatology   179 ( 3 )   790 - 791   2018.9

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  • Two cases of generalized pustular psoriasis complicated by IgG4-related disease. Reviewed

    Miyazawa H, Fujita Y, Iwata H, Ishikawa Y, Nishio S, Ishijima K, Shinmei Y, Takeichi T, Goto K, Oi R, Akiyama M, Shimizu H

    The British journal of dermatology   179 ( 2 )   537 - 539   2018.8

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    DOI： 10.1111/bjd.16712

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  • Potential role of extracellular vesicle-mediated antigen presentation in Helicobacter pylori hypersensitivity during eradication therapy. Reviewed International journal

    Takamasa Ito, Takashi Shiromizu, Shunsuke Ohnishi, Shotaro Suzuki, Katsuhiro Mabe, Akito Hasegawa, Hideyuki Ujiie, Yasuyuki Fujita, Yuichi Sato, Shuji Terai, Mototsugu Kato, Masahiro Asaka, Takeshi Tomonaga, Hiroshi Shimizu, Riichiro Abe

    The Journal of allergy and clinical immunology   142 ( 2 )   672 - 676   2018.8

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  • Sirolimus Gel Treatment vs Placebo for Facial Angiofibromas in Patients With Tuberous Sclerosis Complex: A Randomized Clinical Trial. Reviewed International journal

    Mari Wataya-Kaneda, Yuuki Ohno, Yasuyuki Fujita, Hiroo Yokozeki, Hironori Niizeki, Masaaki Ogai, Kazuyoshi Fukai, Hiroshi Nagai, Yuichi Yoshida, Izumi Hamada, Taihei Hio, Kenji Shimizu, Hiroyuki Murota

    JAMA dermatology   154 ( 7 )   781 - 788   2018.7

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    Importance: Most patients with tuberous sclerosis complex (TSC), an autosomal-dominant disorder that is caused by the constitutive activation of mammalian target of rapamycin, experience disfigurement caused by skin lesions involving facial angiofibromas. Many have been left untreated because of a lack of therapeutic options that are less invasive than surgery or laser treatment. Objective: To confirm the efficacy and safety of sirolimus gel, 0.2%, for treatment of patients with angiofibromas and/or skin lesions. Design, Setting, and Patients: Multicenter, randomized clinical trial at 9 centers in Japan from December 2015 to October 2016 including 62 children and adults with TSC. Interventions: Patients who developed angiofibromas were randomly assigned, in a 1:1 ratio, to receive sirolimus gel, 0.2%, or placebo, each applied topically twice daily for 12 weeks. Main Outcomes and Measures: The primary end point was composite improvement in the size and color of angiofibromas in photographs at week 12 of treatment. It was assessed by an independent review committee comprising 3 blinded dermatologists who categorized patient results into the following 6 categories: "markedly improved," "improved," "slightly improved," "unchanged," "slightly aggravated," and "aggravated." Results: Sixty-two patients (27 pediatric and 35 adult; 34 [55%] female; mean [SD] age, 22.5 [11.9] years) were enrolled and randomly assigned to receive sirolimus gel, 0.2% (30 patients), or placebo (32 patients). The response rates of angiofibromas at weeks 4, 8, and 12 of treatment were 0 each in the placebo group in contrast to 20% (95% CI, 8%-39%; P = .01), 43% (95% CI, 26%-63%; P < .001), and 60% (95% CI, 41%-77%; P < .001), respectively, in the sirolimus group. None of the 31 assessable patients in the placebo group were rated improved or better, and 26 of them (84%) were rated unchanged. In contrast, 5 (17%) and 13 (43%) patients in the sirolimus group were rated markedly improved and improved, respectively. Adverse events were mild to moderate and were observed in 27 (90%) and 22 (69%) patients in the sirolimus and placebo groups, respectively; however, none of the trial participants discontinued treatment. Acute pancreatitis developed as a serious adverse event in 1 patient in the sirolimus group, and the patient recovered soon after hospitalization without discontinuing treatment. Conclusions and Relevance: Sirolimus gel, 0.2%, demonstrated a significant clinical benefit for patients with TSC involving angiofibromas, thus providing a promising therapeutic modality. Trial Registration: ClinicalTrials.gov Identifier: NCT02635789.

    DOI： 10.1001/jamadermatol.2018.1408

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  • Gentamicin-Induced Readthrough and Nonsense-Mediated mRNA Decay of SERPINB7 Nonsense Mutant Transcripts Reviewed International journal

    Yuka Ohguchi, Toshifumi Nomura, Shotaro Suzuki, Masae Takeda, Toshinari Miyauchi, Osamu Mizuno, Satoru Shinkuma, Yasuyuki Fujita, Osamu Nemoto, Kota Ono, W.H. Irwin McLean, Hiroshi Shimizu

    Journal of Investigative Dermatology   138 ( 4 )   836 - 843   2018.4

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    DOI： 10.1016/j.jid.2017.10.014

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  • A solitary reddish nodule on the lower leg Reviewed International journal

    Hajime Miyazawa, Satoru Shinkuma, Yasuyuki Yamaguchi, Yasuyuki Fujita, Toshifumi Nomura, Hiroshi Shimizu

    International Journal of Dermatology   57 ( 3 )   276 - 277   2018.3

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    DOI： 10.1111/ijd.13810

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  • Apocrine mixed tumour on the abdomen: an atypical location Reviewed International journal

    Shoko Mai, Yasuyuki Fujita, Tatsuro Sugai, Keisuke Imafuku, Hiroo Hata, Satoru Shinkuma, Toshifumi Nomura, Naoki Kawagishi, Hiroshi Shimizu

    European Journal of Dermatology   28 ( 2 )   234 - 235   2018.3

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    DOI： 10.1684/ejd.2017.3200

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  • Chromosomal inversions as a hidden disease-modifying factor for somatic recombination phenotypes. Reviewed International journal

    Nomura T, Suzuki S, Miyauchi T, Takeda M, Shinkuma S, Fujita Y, Nishie W, Akiyama M, Shimizu H

    JCI insight   3 ( 6 )   2018.3

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    Heterozygous chromosomal inversions suppress recombination. Therefore, they may potentially influence recombination-associated phenotypes of human diseases, but no studies have verified this hypothesis. Here, we describe a 35-year-old man with severe congenital ichthyosis. Mutation analysis revealed a heterozygous splice-site mutation, c.1374-2A>G (p.Ser458Argfs*120), in KRT10 on 17q21.2. This mutation was previously reported in patients with ichthyosis with confetti type I (IWC-I), a prominent skin disease characterized by the frequent occurrence of recombination-induced reversion of pathogenic mutations. Intriguingly, the number of revertant skin areas in this patient is considerably reduced compared with typical IWC-I cases. G-banded karyotyping revealed that the patient harbors a heterozygous nonpathogenic inversion, inv(17)(p13q12), whose long-arm breakpoint was subsequently refined to chromosomal positions (chr17: 36,544,407-36,639,830) via FISH. Collectively, the only chance of revertant mosaicism through somatic recombination appears to involve recombination between the KRT10 mutation and the inversion breakpoint. Indeed, in the examined revertant spot, the KRT10 mutation was diminished by somatic recombination starting from chromosomal positions (chr17: 36,915,505-37,060,285) on 17q12. This study provides the first evidence to our knowledge implicating chromosomal inversions as a potential modifier of clinical phenotypes. Furthermore, the reduced occurrence of revertant spots in the recombination-suppressed patient suggests that somatic recombination is the main mechanism of revertant mosaicism in IWC-I.

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  • Rapid response to clinical symptoms in early psoriatic onycho-pachydermo-periostitis treated with infliximab. Reviewed International journal

    Keita Horie, Yasuyuki Fujita, Daichi Hoshina, Riichiro Abe, Hiroshi Shimizu

    The Australasian journal of dermatology   59 ( 1 )   e78 - e79   2018.2

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    DOI： 10.1111/ajd.12667

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  • 足底に発生した複合型母斑の悪性黒色腫との鑑別点 Reviewed

    前田 拓哉, 秦 洋郎, 柳 輝希, 今福 恵輔, 北村 真也, 本間 英里奈, 藤田 靖幸, 清水 宏

    日本皮膚科学会雑誌   128 ( 2 )   197 - 203   2018.2

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  • Appearance of antidesmocollin 1 autoantibodies leading to a vegetative lesion in a patient with pemphigus vulgaris Reviewed

    Y. Yamaguchi, S. Shinkuma, N. Ishii, S. Takashima, K. Natsuga, H. Ujiie, H. Iwata, T. Nomura, Y. Fujita, A. Hamasaka, K. Hamasaka, T. Hashimoto, H. Shimizu

    British Journal of Dermatology   178 ( 1 )   294 - 295   2018.1

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    DOI： 10.1111/bjd.15834

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  • Severe subcutaneous hematoma in a patient with psoriatic arthritis: Changes of platelet count in psoriatic patients with biologic agents Reviewed International journal

    Yuka Maya, Yasuyuki Fujita, Chihiro Nakayama, Shinya Kitamura, Hiroo Hata, Ken Arita, Hiroshi Shimizu

    JOURNAL OF DERMATOLOGY   44 ( 12 )   1385 - 1388   2017.12

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    DOI： 10.1111/1346-8138.13981

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  • A case of recessive dystrophic epidermolysis bullosa with a novel c.6885_6898de114 mutation in the COL7A1 gene Reviewed

    Satoru Shinkuma, Tae Masunaga, Saori Miyawaki, Shota Takashima, Ken Natsuga, Toshifumi Nomura, Yasuyuki Fujita, Hideki Nakamura, Hiroshi Shimizu

    JOURNAL OF DERMATOLOGICAL SCIENCE   88 ( 1 )   139 - 141   2017.10

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  • Chemiluminescent enzyme immunoassay failed to detect anti-desmoglein 3 antibodies in a case of pemphigus vulgaris Reviewed International journal

    Yosuke Mai, Hideyuki Ujiie, Machiko Nishimura, Hiroshi Koga, Yuka Maya, Keiko Shiba-Tokuchi, Yasuyuki Fujita, Hiroaki Iwata, Yohei Mikawa, Hiroshi Shimizu

    JOURNAL OF DERMATOLOGY   44 ( 10 )   E242 - E243   2017.10

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  • Subcutaneous Nodule on the Right Palm of a Young Boy: A Quiz Reviewed International journal

    Takuya Maeda, Yasuyuki Fujita, Keisuke Imafuku, Shinichi Nakazato, Hiroo Hata, Toshifumi Nomura, Tomoko Mitsuhashi, Takashi Anan, Tadashi Hasegawa, Shuji Hamaoka, Hiroshi Shimizu

    ACTA DERMATO-VENEREOLOGICA   97 ( 9 )   1150 - 1151   2017.10

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    DOI： 10.2340/00015555-2712

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  • Generalized Pustular Psoriasis Reviewed International journal

    Hideyuki Kosumi, Takamasa Ito, Yasuyuki Fujita, Kentaro Izumi, Yuka Maya, Teruki Yanagi, Ken Natsuga, Hideyuki Ujiie, Satoru Shinkuma, Toshifumi Nomura, Naoya Sadanobu, Hiroshi Shimizu

    JOURNAL OF PEDIATRICS   188   305 - +   2017.9

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    DOI： 10.1016/j.jpeds.2017.05.058

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  • Thymoma-associated multi-organ autoimmunity: two cases and a review of the literature Reviewed

    K. Shiba, Y. Fujita, H. Miyazawa, K. Muramatsu, M. Watanabe, M. Nishimura, S. Shinkuma, T. Nomura, W. Nishie, J. Taguchi, I. Kinoshita, H. Shimizu

    JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY   31 ( 7 )   E324 - E326   2017.7

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    DOI： 10.1111/jdv.14108

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  • アダリムマブが著効したアロポー稽留性肢端皮膚炎の1例 Reviewed

    佐藤 一正, 藤田 靖幸, 葭本 倫大, 椎谷 千尋, 安藤 佐土美, 清水 宏

    皮膚科の臨床   59 ( 8 )   1332 - 1333   2017.7

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    症例(70歳男性)。2年前より右環指先端が腫脹し、疼痛を伴うようになった。また、徐々に両手指に皮疹が拡大し、関節痛も認めたため、当科へ受診となった。初診時、両手指尖端に紅斑・腫脹および圧痛を認め、右環指は爪甲基部が脱落し、爪床には膿疱がみられた。臨床所見・病理組織学的所見よりアロポー稽留性肢端皮膚炎と診断され、マキサカルシトール軟膏外用およびメトトレキサート内服による加療を開始した。約2ヵ月で手指の紅斑は改善したが、関節の腫脹・疼痛は持続したため、アダリムマブの皮下投与を導入したところ、導入2ヵ月後には関節の腫脹や疼痛はすべて消退し、爪変形も著明に改善した。

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  • Late-onset skin involvement on the forehead in multicentric Castleman disease Reviewed

    Kazumasa Sato, Satoru Shinkuma, Hideyuki Ujiie, Toshifumi Nomura, Yasuyuki Fujita, Riichiro Abe, Hiroshi Shimizu, Katsuya Fujimoto, Kanako C. Hatanaka, Yoshihiro Matsuno

    INTERNATIONAL JOURNAL OF DERMATOLOGY   56 ( 7 )   E152 - E153   2017.7

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  • Psoriasis vulgaris with fibrokeratoma from pityriasis amiantacea Reviewed

    Chihiro Shiiya, Yukiko Nomura, Yasuyuki Fujita, Chihiro Nakayama, Hiroshi Shimizu

    JAAD Case Reports   3 ( 3 )   243 - 245   2017.5

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    DOI： 10.1016/j.jdcr.2017.04.002

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  • The first familial cases of epidermolysis bullosa simplex, generalized severe with p.Asn176Ser in KRT5 revealing the clinical chronology Reviewed

    T. Sugai, S. Shinkuma, K. Inafuku, S. Takashima, T. Nomura, Y. Fujita, H. Nakamura, H. Shimizu

    JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY   31 ( 5 )   e251 - e253   2017.5

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  • Reticulated acanthoma with sebaceous differentiation Reviewed

    Shinichi Nakazato, Teruki Yanagi, Yuka Inamura, Shinya Kitamura, Hiroo Hata, Yasuyuki Fujita, Takashi Anan, Masaru Honma, Hiroshi Shimizu

    EUROPEAN JOURNAL OF DERMATOLOGY   27 ( 3 )   318 - 320   2017.5

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  • Psoriasiform mycosis fungoides mas-querading as tumourous plaques Reviewed

    Yasuyuki Yamaguchi, Yasuyuki Fujita, Yu Hirata, Machiko Nishimura, Satoru Shinkuma, Ken Natsuga, Toshifumi Nomura, Tokimasa Hida, Naoko Kato, Hiroshi Shimizu

    EUROPEAN JOURNAL OF DERMATOLOGY   27 ( 3 )   295 - 296   2017.5

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  • Complete remission of angiolymphoid hyperplasia with eosinophilia using topical tacrolimus Reviewed

    Shinpei Harada, Toshifumi Nomura, Toshinari Miyauchi, Satoru Shinkuma, Yasuyuki Fujita, Ken Arita, Hiroshi Shimizu

    EUROPEAN JOURNAL OF DERMATOLOGY   27 ( 2 )   194 - 196   2017.3

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  • Acrokeratoelastoidosis successfully treated with 10% salicylic acid ointment Reviewed

    Chihiro Shiiya, Hiroo Hata, Yuka Inamura, Keisuke Imafuku, Shinya Kitamura, Teruki Yanagi, Yasuyuki Fujita, Hiroshi Shimizu

    JOURNAL OF DERMATOLOGY   44 ( 3 )   E46 - E47   2017.3

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  • Hypertrophic lupus erythematosus successfully treated with hydroxychloroquine Reviewed

    Norihiro Yoshimoto, Satoru Shinkuma, Hideyuki Ujiie, Toshifumi Nomura, Yasuyuki Fujita, Riichiro Abe, Hiroshi Shimizu

    JOURNAL OF DERMATOLOGY   44 ( 3 )   E48 - E49   2017.3

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  • A severe case of X-linked ichthyosis showing palmar hyperlinearity without FLG mutations Reviewed

    S. Katayama, T. Nomura, K. Muramatsu, M. Takeda, T. Miyauchi, S. Suzuki, S. Shinkuma, Y. Fujita, H. Iwata, H. Shimizu

    JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY   31 ( 2 )   E119 - E120   2017.2

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  • Image Gallery: Vasculo-Behcet disease Reviewed

    K. Muramatsu, H. Ujiie, T. Ito, Y. Fujita, D. Inokuma, I. Tsukinaga, T. Abe, S. Shirai, N. Fukuda, H. Shimizu

    BRITISH JOURNAL OF DERMATOLOGY   175 ( 6 )   E150 - E150   2016.12

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  • Two cases of erosive oral lichen planus with autoantibodies to desmoglein 3 Reviewed

    Ken Muramatsu, Wataru Nishie, Ken Natsuga, Yasuyuki Fujita, Hiroaki Iwata, Tamaki Yamada, Emi Yamashita, Takuya Asaka, Hiroshi Shimizu

    JOURNAL OF DERMATOLOGY   43 ( 11 )   1350 - 1353   2016.11

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  • Genetic analysis of a novel splice-site mutation in TMC8 reveals the in vivo importance of the transmembrane channel-like domain of TMC8 Reviewed

    T. Miyauchi, T. Nomura, S. Suzuki, A. Takeda, S. Shinkuma, K. Arita, Y. Fujita, H. Shimizu

    BRITISH JOURNAL OF DERMATOLOGY   175 ( 4 )   803 - 806   2016.10

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  • Dermoscopic findings of irritated seborrheic keratosis Reviewed

    S. Kitamura, H. Hata, K. Imafuku, Y. Fujita, H. Shimizu

    JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY   30 ( 10 )   E94 - E96   2016.10

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  • Revertant Mosaicism in Ichthyosis with Confetti Caused by a Frameshift Mutation in KRT1 Reviewed

    Shotaro Suzuki, Toshifumi Nomura, Toshinari Miyauchi, Masae Takeda, Hideki Nakamura, Satoru Shinkuma, Yasuyuki Fujita, Masashi Akiyama, Hiroshi Shimizu

    JOURNAL OF INVESTIGATIVE DERMATOLOGY   136 ( 10 )   2093 - 2095   2016.10

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  • Silicone medical adhesive removers for hyperkeratosis in epidermolysis bullosa Reviewed

    Yasuyuki Fujita, Satoru Shinkuma, Wakana Matsumura, Ken Natsuga, Hiroo Hata, Toshifumi Nomura, Hiroshi Shimizu

    EUROPEAN JOURNAL OF DERMATOLOGY   26 ( 5 )   501 - 502   2016.9

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    DOI： 10.1684/ejd.2016.2817

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  • 顔面の巨大な腫瘤に対して電子線照射療法が著効した菌状息肉症の1例 Reviewed

    葭本 倫大, 藤田 靖幸, 平田 悠, 保科 大地, 守内 玲寧, 氏家 英之, 井上 哲也, 清水 宏

    皮膚科の臨床   58 ( 10 )   1483 - 1487   2016.9

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    62歳女。左下腿の疼痛・腫脹、全身の紅斑を主訴とした。54歳時に紅斑期菌状息肉症(MF)と診断されたが通院を自己中断していた。顔面に出現した紅斑が急速に隆起して右上眼瞼に75mm大、眉間に55mm大、上口唇に50mm大の腫瘤を形成して右眼は開眼不能であり、腫瘤期MFと診断した。左下腿の疼痛・腫脹は蜂窩織炎と診断してセフェピムおよびクリンダマイシン連日投与を行い、1週間で全身状態改善後、エトレチナート内服を併用しつつ週5回のメトキサレン内服による内服PUVA療法に加え、顔面の腫瘤に対して40Gy/20Frの電子線照射を施行した。腫瘤は瘢痕を残して速やかに消退し、4年経過時点で顔面病変は寛解を維持している。

    DOI： 10.18888/J01266.2016404553

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  • 活性型ビタミンD3軟膏使用中に飼い犬に腎不全をきたした尋常性乾癬の1例 Reviewed

    藤田 靖幸, 須藤 明日香, 清水 宏, 華園 究, 中村 健介, 内田 英二, 川畑 智敬

    日本皮膚科学会雑誌   126 ( 9 )   1726 - 1726   2016.8

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  • Eosinophilic pustular folliculitis in a patient with mycosis fungoides Reviewed

    S. Takashima, W. Nishie, Y. Morita, R. Osawa, H. Iwata, Y. Fujita, K. Fujimoto, H. Shimizu

    JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY   30 ( 4 )   712 - 713   2016.4

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  • Dermoscopy of periungual pigmented Bowen's disease: its usefulness in differentiation from malignant melanoma Reviewed

    C. Nakayama, H. Hata, E. Homma, Y. Fujita, H. Shimizu

    JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY   30 ( 3 )   552 - 554   2016.3

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  • RNA recognition motif of LEMD3 as a key player in the pathogenesis of Buschke-Ollendorff syndrome Reviewed

    Shota Takashima, Yasuyuki Fujita, Shotaro Suzuki, Nao Saito, Satoru Shinkuma, Toshifumi Nomura, Hiroshi Shimizu

    JOURNAL OF DERMATOLOGICAL SCIENCE   81 ( 3 )   205 - 208   2016.3

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    DOI： 10.1016/j.jdermsci.2015.12.002

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  • Safety of ustekinumab for the treatment of psoriasis vulgaris with myotonic dystrophy Reviewed

    Yasuyuki Fujita, Satoru Shinkuma, Toshifumi Nomura, Hiroshi Shimizu

    EUROPEAN JOURNAL OF DERMATOLOGY   26 ( 2 )   187 - 188   2016.3

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    DOI： 10.1684/ejd.2015.2688

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  • Fasciitis-panniculitis Syndromeの1例 Reviewed

    白戸 貴久, 藤田 靖幸, 高島 翔太, 齋藤 奈央, 乃村 俊史, 堀田 哲也, 清水 宏

    皮膚科の臨床   58 ( 2 )   232 - 235   2016.2

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    40歳男。1年半前より下肢の運動時制限を自覚し、徐々に四肢の硬化を認めたため当科を受診した。受診時、両手背から前腕、足背から下腿にかけてびまん性に皮膚が硬化し、前腕では表在静脈に沿って線状に陥凹していた。造影MRIで両下腿筋膜が高信号を呈していた。病理組織学的所見より、fasciitis-panniculitis syndromeと診断された。診断後はプレドニゾロンの内服を開始したところ、硬化と可動域制限は徐々に改善した。

    DOI： 10.18888/J01266.2016168071

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    Other Link： http://search.jamas.or.jp/link/ui/2016168071

  • 進行性顔面片側萎縮症の1例 Reviewed

    堀田 萌子, 藤田 靖幸, 葭本 倫大, 剱持 靖子, 夏賀 健, 冨澤 幸生, 清水 宏

    皮膚科の臨床   58 ( 1 )   150 - 151   2016.1

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    9歳男児。約半年前から左頬部に陥凹が出現し、徐々に拡大してきたため、当科を紹介受診した。初診時、左頬全体に常色で境界不明瞭な陥凹を認め、病理組織学的所見・MRI所見より、進行性顔面片側萎縮症と診断した。診断後は無治療にて経過観察しているが、現在までに症状の増悪はみられない。

    DOI： 10.18888/J01266.2016149808

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  • Nodular morphoea: a first case associated with linear morphoea Reviewed

    Shinichi Nakazato, Toshifumi Nomura, Naoko Yamane, Satoru Shinkuma, Ken Natsuga, Yasuyuki Fujita, Ken Arita, Hiroshi Shimizu

    EUROPEAN JOURNAL OF DERMATOLOGY   26 ( 1 )   95 - 96   2016.1

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  • Cutaneous Manifestations of Thymoma-associated Multi-organ Autoimmunity: A Fatal Sign Reviewed

    Ken Murarnatsu, Yasuyuki Fujita, Daisuke Inokuma, Ichiro Tsukinaga, Kenichiro Ito, Youichi Nishiura, Hiroshi Shimizu

    ACTA DERMATO-VENEREOLOGICA   96 ( 6 )   818 - 819   2016

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    DOI： 10.2340/00015555-2367

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  • Extensive Erythema and Hyperkeratosis on the Extremities and Lumbar Area as an Unusual Manifestation of Nagashima-type Palmoplantar Keratosis Reviewed

    Toshinari Miyauchi, Toshifumi Nomura, Shotaro Suzuki, Yuka Ohg-Uchi, Yasuyuki Yamaguchi, Satoru Shinkuma, Ken Natsuga, Yasuyuki Fujita, Hiroshi Shimizu

    ACTA DERMATO-VENEREOLOGICA   96 ( 6 )   856 - 858   2016

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  • Localized pemphigus vulgaris clinically masquerading as lichen planus and actinic keratosis Reviewed

    Hidetsugu Sato, Yasuyuki Fujita, Yohei Hamade, Ken Muramatsu, Shinichi Nakazato, Keisuke Kikuchi, Naoya Haga, Nao Saito, Hiroshi Shimizu

    JOURNAL OF DERMATOLOGY   42 ( 12 )   1204 - 1205   2015.12

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    DOI： 10.1111/1346-8138.13099

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  • トラニラスト内服で症状の改善を示した粘液水腫性苔癬の1例 Reviewed

    平田 悠, 藤田 靖幸, 大澤 倫子, 西江 渉, 清水 宏

    皮膚科の臨床   57 ( 13 )   2041 - 2044   2015.12

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    48歳男。顔面・頸部の丘疹・腫脹が2ヵ月前から出現した。初診時は前額部・上眼瞼・鼻背を中心に硬化を伴う淡紅色の扁平隆起局面を認め、後頸部から上背部にはびまん性に硬化し局面上に10mm大までの淡紅色丘疹が散在していた。病理組織像では真皮浅層に著明な浮腫があり、膠原線維束間にムチン沈着を認めた。粘液水腫性苔癬のうちatypical formと診断した。トラニラスト内服1ヵ月後には皮疹は軽快し、現在も内服加療中である。

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    Other Link： http://search.jamas.or.jp/link/ui/2016120566

  • Striate palmoplantar keratoderma: Report of a novel DSG1 mutation and atypical clinical manifestations Reviewed

    Toshifumi Nomura, Osamu Mizuno, Toshinari Miyauchi, Shotaro Suzuki, Satoru Shinkuma, Hiroo Hata, Yasuyuki Fujita, Masashi Akiyama, Hiroshi Shimizu

    JOURNAL OF DERMATOLOGICAL SCIENCE   80 ( 3 )   223 - 225   2015.12

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  • Identification of previously unknown SERPINB7 splice variants in patients with Nagashima-type palmoplantar keratosis reveals the importance of the CD-loop of SERPINB7 Reviewed

    S. Suzuki, T. Nomura, O. Mizuno, Y. Fujita, H. Shimizu

    BRITISH JOURNAL OF DERMATOLOGY   173 ( 5 )   1288 - 1290   2015.11

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  • Development of bullous pemphigoid during treatment of psoriatic onycho-pachydermo periostitis with ustekinumab Reviewed

    Chihiro Nakayama, Yasuyuki Fujita, Mika Watanabe, Hiroshi Shimizu

    JOURNAL OF DERMATOLOGY   42 ( 10 )   996 - 998   2015.10

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    DOI： 10.1111/1346-8138.12943

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  • Tuberculoid reaction to a cosmetic tattoo on the lips Reviewed

    Matsumura, W., Ito, K., Fujita, Y., Watanabe, E., Iitani, M.M., Nomura, T., Sasaki, M., Kobayashi, H.

    European Journal of Dermatology   25 ( 5 )   485 - 487   2015.9

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    DOI： 10.1684/ejd.2015.2548

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  • Serum granulysin levels as a predictor of serious telaprevir-induced dermatological reactions. Reviewed

    Suda G, Yamamoto Y, Nagasaka A, Furuya K, Kudo M, Chuganji Y, Tsukuda Y, Tsunematsu S, Sato F, Terasita K, Nakai M, Horimoto H, Sho T, Natsuizaka M, Ogawa K, Ohnishi S, Chuma M, Fujita Y, Abe R, Taniguchi M, Nakagawa M, Asahina Y, Sakamoto N, NORTE Study Group

    Hepatology research : the official journal of the Japan Society of Hepatology   45 ( 8 )   837 - 845   2015.8

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    DOI： 10.1111/hepr.12421

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  • Acase of papular elastolytic giant cell granuloma: A mini-review of reported cases Reviewed

    Shinichi Nakazato, Yasuyuki Fujita, Ken Muramatsu, Keisuke Kikuchi, Hidetsugu Sato, Hiroshi Shimizu

    EUROPEAN JOURNAL OF DERMATOLOGY   25 ( 2 )   205 - 206   2015.4

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  • MMP13 can be a useful differentiating marker between squamous cell carcinoma and benign hyperkeratotic lesions in recessive dystrophic epidermolysis bullosa Reviewed

    H. Hata, R. Abe, A. Suto, E. Homma, Y. Fujita, S. Aoyagi, H. Shimizu

    BRITISH JOURNAL OF DERMATOLOGY   172 ( 3 )   769 - 773   2015.3

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    DOI： 10.1111/bjd.13302

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  • Dermoscopic observation in adenoma of the nipple Reviewed

    Shota Takashima, Yasuyuki Fujita, Toshinari Miyauchi, Toshifumi Nomura, Wataru Nishie, Hideji Hamaoka, Hiroshi Shimizu

    JOURNAL OF DERMATOLOGY   42 ( 3 )   341 - 342   2015.3

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    DOI： 10.1111/1346-8138.12780

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  • Pruritic Papules Following Lumbar Corset Use: A Quiz Grover's disease Reviewed

    Toshinari Miyauchi, Yasuyuki Fujita, Shota Takashima, Yusuke Morita, Shotaro Suzuki, Osamu Mizuno, Nao Saito, Toshifumi Nomura, Hiroshi Shimizu

    ACTA DERMATO-VENEREOLOGICA   95 ( 6 )   763 - +   2015

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    DOI： 10.2340/00015555-2071

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  • Highly prevalent SERPINB7 founder mutation causes pseudodominant inheritance pattern in Nagashima-type palmoplantar keratosis Reviewed

    O. Mizuno, T. Nomura, S. Suzuki, M. Takeda, Y. Ohguchi, Y. Fujita, W. Nishie, K. Sugiura, M. Akiyama, H. Shimizu

    BRITISH JOURNAL OF DERMATOLOGY   171 ( 4 )   847 - 853   2014.10

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    DOI： 10.1111/bjd.13076

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  • Tubular apocrine adenoma clinically and dermoscopically mimicking basal cell carcinoma Reviewed

    Takamasa Ito, Toshifumi Nomura, Yasuyuki Fujita, Riichiro Abe, Hiroshi Shimizu

    JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY   71 ( 2 )   E45 - E46   2014.8

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  • An annexin A1-FPR1 interaction contributes to necroptosis of keratinocytes in severe cutaneous adverse drug reactions Reviewed

    Nao Saito, Hongjiang Qiao, Teruki Yanagi, Satoru Shinkuma, Keiko Nishimura, Asuka Suto, Yasuyuki Fujita, Shotaro Suzuki, Toshifumi Nomura, Hideki Nakamura, Koji Nagao, Chikashi Obuse, Hiroshi Shimizu, Riichiro Abe

    SCIENCE TRANSLATIONAL MEDICINE   6 ( 245 )   245ra95   2014.7

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    DOI： 10.1126/scitranslmed.3008227

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  • Spontaneously resolving granulomatous tattoo reaction in multiple color regions Reviewed

    Takamasa Ito, Yasuyuki Fujita, Wataru Nishie, Yu Hirata, Hiroshi Shimizu

    JOURNAL OF DERMATOLOGY   41 ( 7 )   647 - 648   2014.7

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    DOI： 10.1111/1346-8138.12531

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  • Non-bullous neutrophilic dermatosis in a patient with systemic lupus erythematosus Reviewed

    中山 ちひろ, 齋藤 奈央, 伊東 孝政, 中里 信一, 堀江 啓太, 乃村 俊史, 藤田 靖幸, 阿部 理一郎, 坊垣 暁之, 小玉 和郎, 清水 宏

    臨床皮膚科   68 ( 8 )   591 - 595   2014.7

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    DOI： 10.11477/mf.1412104073

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  • Desmoplastic Blue Nevusの1例 Reviewed

    辻脇 真澄, 藤田 靖幸, 村田 純子, 乃村 俊史, 西江 渉, 清水 宏

    皮膚科の臨床   56 ( 6 )   893 - 896   2014.6

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    55歳男。約10年前より右手首に皮疹を認めていた。右尺骨遠位端上の皮膚に20×15mm大の境界明瞭で可動性良好な楕円形の淡紅色の結節があり、中央部に5mm大の青色斑を伴っていた。病理組織学的に真皮内に境界明瞭な結節性病変を認め、また著明な膠原線維の増生があり、その間に有色素性の紡錘形細胞が増殖していた。紡錘形細胞はCD68陽性のメラノファージとS-100陽性、HMB-45陽性、MART-1陽性細胞が混在していた。Factor XIIIaは陰性であった。以上よりdesmoplastic blue nevusと診断し、全摘切除術を施行した。術後経過は良好で、再発は認めていない。

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  • 成人型肥満細胞症の2例 Reviewed

    中里 信一, 藤田 靖幸, 氏家 英之, 西江 渉, 阿部 理一郎, 近藤 健, 清水 宏

    皮膚科の臨床   56 ( 4 )   595 - 599   2014.4

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    症例1は50歳女性で、30年前よりそう痒を伴う皮疹を自覚し、3ヵ月前に頭痛があり、1ヵ月前から全身のそう痒が強くなり、腹痛、嘔気、下痢を繰り返すようになり、当科紹介となった。症例2は56歳男性で、全身のそう痒を伴う皮疹を主訴に当科を受診した。臨床像と病理組織像から、いずれの症例も肥満細胞症と診断した。症例1はフェキソフェナジン塩酸塩、レボセチリジン塩酸塩、ベポタスチンベシル酸塩の内服にて全身のそう痒は一時軽快したが、膝痛に対するフェルビナク貼布剤を追加後、頭痛や消化器症状、顔面の発赤、呼吸苦などを生じ、発作に対してはプレドニゾロン内服が有効であった。症例2は皮疹以外に症状は認めず、無治療にて7年間著変なく経過している。

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  • 若年女性の好酸球性膿疱性毛包炎の1例と当科19例の検討 Reviewed

    中里 信一, 藤田 靖幸, 濱出 洋平, 平田 悠, 長谷部 育恵, 浜坂 明日香, 西江 渉, 清水 宏

    皮膚科の臨床   56 ( 3 )   341 - 344   2014.3

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    症例は15歳女性で、右前腕と左下肢のそう痒を伴う皮疹を主訴に近医にて加療されるも改善しなかったため受診した。当初、二次感染を伴う貨幣状湿疹として治療を開始したが、毛孔一致性の鮮紅色丘疹と小膿疱が多発し、急速に四肢へ拡大したため、初診10日後に入院となった。膿疱からの細菌培養は陰性で、病理組織学的所見より好酸球性膿疱性毛包炎(EPF)と診断した。入院後、クロベタゾールプロピオン酸エステルの外用、インドメタシンファルネシル400mgの内服を開始したところ、皮疹は軽快した。2年以上経過した現在、インドメタシンファルネシル300〜400mgを内服継続することで寛解状態を維持している。当科で経験したEPF19例の検討では、男女比は10:9と偏りがなく、年齢は10〜50歳代と幅広く分布していた。

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  • 皮疹から診断に至った小児皮膚筋炎の1例 Reviewed

    足立 真紀, 藤田 靖幸, 中里 信一, 西江 渉, 小林 一郎, 小林 仁, 清水 宏

    皮膚科の臨床   56 ( 2 )   158 - 159   2014.2

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    2歳女。顔面・手指伸側・大腿の皮疹を主訴とした。両頬部と鼻根部に鮮紅色の浮腫性紅斑、両手指関節部に径1cmまでの角化性紅斑を認めた。血液検査で筋原性酵素の軽度上昇を認め、皮膚生検では空胞変性と真皮浅層の血管周囲にリンパ球浸潤を認め、ムチン沈着を伴っていた。MRIでは脂肪抑制画像で両側臀部・大腿の筋・筋膜・両側上肢の筋群に不均一な信号上昇を認め、活動性のある筋炎の存在が示唆された。CTで間質性肺炎や腫瘍性病変の所見は認めなかった。左上腕三頭筋の生検病理所見では筋束周囲の筋萎縮を認めた。小児皮膚筋炎と診断してプレドニゾロン25mg/日とメトトレキサート4mg/週の投与を開始し、皮疹や筋炎症状が改善したため約4週後にプレドニゾロンを漸減し、約2ヵ月後に退院となった。退院後8ヵ月に手指紅斑が再燃したため、プレドニゾロンを12mg/日、更にメトトレキサートを6mg/週に増量し経過観察している。

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  • Repeated skin sampling and prolonged incubation period identified cutaneous Mycobacterium chelonae infection on the face in an immunocompetent man Reviewed

    K. Muramatsu, T. Nomura, T. Ito, Y. Hamade, Y. Hirata, Y. Fujita, R. Abe, H. Shimizu

    BRITISH JOURNAL OF DERMATOLOGY   170 ( 2 )   471 - 473   2014.2

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  • Long-term Follow-up of Cultured Epidermal Autograft in a Patient with Recessive Dystrophic Epidermolysis Bullosa Reviewed

    Satoru Shinkuma, Daisuke Sawamura, Yasuyuki Fujita, Hiroyuki Kawasaki, Hiroyuki Nakamura, Masukazu Inoie, Wataru Nishie, Hiroshi Shimizu

    ACTA DERMATO-VENEREOLOGICA   94 ( 1 )   98 - 99   2014

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  • Recurrent Course and CD30 Expression of Atypical T Lymphocytes Distinguish Lymphomatoid Papulosis From Primary Cutaneous Aggressive Epidermotropic CD8(+) Cytotoxic T-cell Lymphoma Reviewed

    Masumi Tsujiwaki, Riichiro Abe, Yuka Ohguchi, Daichi Hoshina, Junko Murata, Yasuyuki Fujita, Toshifumi Nomura, Midori Ambo, Hiroshi Shimizu

    ACTA DERMATO-VENEREOLOGICA   94 ( 5 )   613 - 614   2014

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  • Tubular Spitz Naevus Mimicking Eccrine Spiradenoma Reviewed

    Yasuyuki Fujita, Satoru Aoyagi, Masumi Tsujiwaki, Erina Homma, Hideyuki Ujiie, Hiromi Fujita, Kanako C. Hatanaka, Hiroshi Shimizu

    ACTA DERMATO-VENEREOLOGICA   94 ( 1 )   114 - 115   2014

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  • LC-MS/MS Analysis of Canine Lipoproteins Fractionated Using the Ultracentrifugation-Precipitation Method (vol 75, pg 1471, 2013) Reviewed

    Asuka Suto, Masahiro Yamasaki, Yukari Takasaki, Yasuyuki Fujita, Riichiro Abe, Hiroshi Shimizu, Hiroshi Ohta, Mitsuyoshi Takiguchi

    JOURNAL OF VETERINARY MEDICAL SCIENCE   75 ( 12 )   1678 - 1678   2013.12

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  • LC-MS/MS analysis of canine lipoproteins fractionated using the ultracentrifugation-precipitation method. Reviewed

    Asuka Suto, Masahiro Yamasaki, Yukari Takasaki, Yasuyuki Fujita, Riichiro Abe, Hiroshi Shimizu, Hiroshi Ohta, Mitsuyoshi Takiguchi

    The Journal of veterinary medical science   75 ( 11 )   1471 - 7   2013.11

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    Due to the lack of a gold standard method in canine lipoprotein analysis, it is unclear whether canine high-density lipoprotein (HDL) and low-density lipoprotein (LDL) can be accurately evaluated by the lipoprotein analysis methods used for dogs. This study investigated whether the ultracentrifugation-precipitation (U-P) method was suitable as a gold standard method for analyzing canine lipoprotein. First, the U-P method was compared with a gel permeation high-performance liquid chromatography system (GP-HPLC). The concentrations of canine HDL cholesterol (HDL-C) and LDL cholesterol (LDL-C) determined by the U-P method correlated closely with those determined by GP-HPLC. However, the canine HDL-C concentration determined by the U-P method was lower than that determined by GP-HPLC, and the canine LDL-C concentration determined by the U-P method was higher than that determined by GP-HPLC. This study showed that some canine HDL could be precipitated with heparin manganese chloride solution. Second, the HDL and LDL fractions separated by the U-P method were analyzed by LC-MS/MS. The HDL fraction was found to contain only apolipoprotein A-I, which is an apolipoprotein of HDL, whereas the LDL fraction contained both apolipoprotein A-I and apolipoprotein B-100, which is an apolipoprotein of LDL. This data showed that a certain lipoprotein that includes apolipoprotein A-I might precipitate with canine LDL when using heparin manganese chloride solution. These results indicated that the U-P method is not currently a gold standard method for analyzing canine lipoproteins.

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  • Dermoscopy of pseudoxanthoma elasticum-like papillary dermal elastolysis. Reviewed International journal

    Takamasa Ito, Yasuyuki Fujita, Toshifumi Nomura, Riichiro Abe, Hiroshi Shimizu

    Journal of the American Academy of Dermatology   69 ( 4 )   e202-3 - 3   2013.10

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    DOI： 10.1016/j.jaad.2013.04.059

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  • 顔面の腫脹から診断に至った皮下脂肪織炎様T細胞性リンパ腫の1例 Reviewed

    中里 信一, 藤田 靖幸, 古口 華子, 長谷部 育恵, 近藤 健, 白鳥 聡一, 西江 渉, 清水 宏

    皮膚科の臨床   55 ( 9 )   1204 - 1205   2013.9

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    19歳男性。左頬部の腫脹を主訴に複数の医療機関を受診するも原因は特定できず、発熱も加わったため著者らの口腔外科へ受診となった。白血球減少や肝機能障害ほか、MRIにてWeber-Christian病が疑われ、皮膚科へ紹介となったが、所見では左頬〜下顎にかけて熱感を伴うびまん性の腫脹がみられ、同部位の皮下には1〜2cm大の硬結が複数触知された。また、MRIでは両頬部と後頸部の皮下脂肪層内に索状病変が確認され、PET-CTでは頸部、胸部、腹部、上腕の皮下組織にFDG集積が多発していた。以上、これらの所見を踏まえ、あわせて皮膚病理所見から本症例は皮下脂肪織炎様T細胞性リンパ腫の診断され、CHOP療法を6コース施行した結果、現在のところmetabolic CRを保っている。

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  • 慢性骨髄性白血病を合併したWells症候群 Invited Reviewed

    中里 信一, 藤田 靖幸, 濱出 洋平, 長谷部 育恵, 杉田 純一, 西江 渉, 清水 宏

    皮膚病診療   35 ( 9 )   881 - 884   2013.9

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  • Disturbed balance in three subpopulations of CD4(+) Foxp3(+) regulatory T cells in Stevens-Johnson syndrome and toxic epidermal necrolysis patients Reviewed

    Naoya Yoshioka, Asuka Suto, Riichiro Abe, Nao Saito, Junko Murata, Inkin Hayashi-Ujiie, Daichi Hoshina, Yasuyuki Fujita, Hiroshi Shimizu

    CLINICAL IMMUNOLOGY   148 ( 1 )   89 - 91   2013.7

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  • Establishment of a novel experimental model of human angiosarcoma and a VEGF-targeting therapeutic experiment Reviewed

    Daichi Hoshina, Riichiro Abe, Naoya Yoshioka, Nao Saito, Hiroo Hata, Yasuyuki Fujita, Satoru Aoyagi, Hiroshi Shimizu

    JOURNAL OF DERMATOLOGICAL SCIENCE   70 ( 2 )   116 - 122   2013.5

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    DOI： 10.1016/j.jdermsci.2013.02.008

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  • A Method for Intravital Monitoring of Human Cells Using a Far-Red Luminescent Probe in Graft-Versus-Host Disease Model Mice Reviewed

    Hongjiang Qiao, Riichiro Abe, Nao Saito, Yasuyuki Fujita, Inkin Hayashi-Ujiie, Gang Wang, Sanae Haga, Chun Wu, Yoshihiro Ohmiya, Michitaka Ozaki, Hiroshi Shimizu

    JOURNAL OF INVESTIGATIVE DERMATOLOGY   133 ( 3 )   841 - 843   2013.3

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  • Stevens-Johnson syndrome/toxic epidermal necrolysis mouse model generated by using PBMCs and the skin of patients Reviewed

    Nao Saito, Naoya Yoshioka, Riichiro Abe, Hongjiang Qiao, Yasuyuki Fujita, Daichi Hoshina, Asuka Suto, Satoru Kase, Nobuyoshi Kitaichi, Michitaka Ozaki, Hiroshi Shimizu

    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY   131 ( 2 )   434 - +   2013.2

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    DOI： 10.1016/j.jaci.2012.09.014

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  • Wells' Syndrome Associated with Chronic Myeloid Leukaemia Reviewed

    Shinichi Nakazato, Yasuyuki Fujita, Yohei Hamade, Ikue Nemoto-Hasebe, Junichi Sugita, Wataru Nishie, Hiroshi Shimizu

    ACTA DERMATO-VENEREOLOGICA   93 ( 3 )   375 - 376   2013

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    DOI： 10.2340/00015555-1483

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  • Efficacy of N-(3,4-dimethoxycinnamoyl)-anthranilic acid (tranilast) against eruptive syringoma: Report of two cases and review of published work Reviewed

    Keita Horie, Satoru Shinkuma, Yasuyuki Fujita, Hideyuki Ujiie, Satoru Aoyagi, Hiroshi Shimizu

    JOURNAL OF DERMATOLOGY   39 ( 12 )   1044 - 1046   2012.12

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  • Prolonged elevation of serum granulysin in drug-induced hypersensitivity syndrome Reviewed

    N. Saito, R. Abe, N. Yoshioka, J. Murata, Y. Fujita, H. Shimizu

    BRITISH JOURNAL OF DERMATOLOGY   167 ( 2 )   452 - 453   2012.8

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  • Circumscribed palmar hypokeratosis: correlation between histopathological patterns and dermoscopic findings Reviewed

    M. Nishimura, W. Nihie, S. Nakazato, I. Nemoto-Hasebe, Y. Fujita, H. Shimizu

    BRITISH JOURNAL OF DERMATOLOGY   167 ( 1 )   221 - 222   2012.7

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  • Unusual cutaneous manifestations of Churg-Strauss syndrome mimicking Wells' syndrome Reviewed

    Wakana Omiya, Yasuyuki Fujita, Keiko Baba, Akihiko Shibaki, Toshio Odani, Hiroshi Shimizu

    EUROPEAN JOURNAL OF DERMATOLOGY   22 ( 4 )   576 - 578   2012.7

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    DOI： 10.1684/ejd.2012.1781

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  • Conversion from human haematopoietic stem cells to keratinocytes requires keratinocyte secretory factors Reviewed

    Fujita, Y., Inokuma, D., Abe, R., Sasaki, M., Nakamura, H., Shimizu, T., Shimizu, H.

    Clinical and Experimental Dermatology   37 ( 6 )   2012.2

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    DOI： 10.1111/j.1365-2230.2011.04312.x

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  • Rapid immunochromatographic test for serum granulysin is useful for the prediction of Stevens-Johnson syndrome and toxic epidermal necrolysis Reviewed

    Yasuyuki Fujita, Naoya Yoshioka, Riichiro Abe, Junko Murata, Daichi Hoshina, Hirokatsu Mae, Hiroshi Shimizu

    JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY   65 ( 1 )   65 - 68   2011.7

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    DOI： 10.1016/j.jaad.2010.04.042

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  • 多彩な皮疹を呈した第2期梅毒疹 Reviewed

    林韻欣, 藤田靖幸, 有田賢, 清水宏

    皮膚科の臨床   52 ( 12 )   1897-1900,1787-1788 - 1900,1787〜1788   2010.11

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  • Effective treatment for porphyria cutanea tarda with oral cimetidine Reviewed

    Yasuyuki Fujita, Kazuko C. Sato-Matsumura

    JOURNAL OF DERMATOLOGY   37 ( 7 )   677 - 679   2010.7

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    DOI： 10.1111/j.1346-8138.2010.00838.x

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  • Mutation analyses of patients with dyschromatosis symmetrica hereditaria: Five novel mutations of the ADAR1 gene Reviewed

    Ichidai Murata, Masahiro Hayashi, Yutaka Hozumi, Kazuyasu Fujii, Yoshihiko Mitsuhashi, Naoki Oiso, Kazuyoshi Fukai, Nozomi Kuroki, Yasuki Mori, Atsushi Utani, Yasushi Tomita, Yasuyuki Fujita, Tamio Suzuki

    JOURNAL OF DERMATOLOGICAL SCIENCE   58 ( 3 )   218 - 220   2010.6

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  • Topical application of anti-angiogenic peptides based on pigment epithelium-derived factor can improve psoriasis Reviewed

    Riichiro Abe, Sho-ichi Yamagishi, Yasuyuki Fujita, Daichi Hoshina, Mikako Sasaki, Kazuo Nakamura, Takanori Matsui, Tadamichi Shimizu, Richard Bucala, Hiroshi Shimizu

    JOURNAL OF DERMATOLOGICAL SCIENCE   57 ( 3 )   183 - 191   2010.3

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    DOI： 10.1016/j.jdermsci.2009.12.010

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  • Generalized exacerbation of systemic allergic dermatitis due to zinc patch test and dental treatments Reviewed

    Nao Saito, Naoko Yamane, Wakana Matsumura, Yasuyuki Fujita, Daisuke Inokuma, Shin-Ichiro Kuroshima, Koukichi Hamasaka, Hiroshi Shimizu

    CONTACT DERMATITIS   62 ( 6 )   372 - 373   2010

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  • Pyoderma Gangrenosum of the Eyelid: Report of Two Cases and Review of the Literature Reviewed

    N. Saito, T. Yanagi, M. Akiyama, H. Y. Lin, S. Kasai, Y. Fujita, N. Yamane, D. Inokuma, S. Kase, K. Ono, H. Minakawa, H. Shimizu

    DERMATOLOGY   221 ( 3 )   211 - 215   2010

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    DOI： 10.1159/000317079

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  • Secondary syphilis mimicking warts in an HIV-positive patient Reviewed

    S. Shinkuma, R. Abe, M. Nishimura, K. Natsuga, Y. Fujita, T. Nomura, W. Nishie, H. Shimizu

    SEXUALLY TRANSMITTED INFECTIONS   85 ( 6 )   484 - 484   2009.10

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  • Granulysin as a Marker for Early Diagnosis of the Stevens-Johnson Syndrome Reviewed

    Riichiro Abe, Naoya Yoshioka, Junko Murata, Yasuyuki Fujita, Hiroshi Shimizu

    ANNALS OF INTERNAL MEDICINE   151 ( 7 )   514 - 515   2009.10

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  • DNA vaccination against macrophage migration inhibitory factor improves atopic dermatitis in murine models Reviewed

    Asuka Hamasaka, Riichiro Abe, Yoshikazu Koyama, Naoya Yoshioka, Yasuyuki Fujita, Daichi Hoshina, Mikako Sasaki, Tsutomu Hirasawa, Shin Onodera, Shigeki Ohshima, Lin Leng, Richard Bucala, Jun Nishihira, Tadamichi Shimizu, Hiroshi Shimizu

    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY   124 ( 1 )   90 - 99   2009.7

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    DOI： 10.1016/j.jaci.2009.04.025

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  • Type XVII Collagen is a Key Player in Tooth Enamel Formation Reviewed

    Takuya Asaka, Masashi Akiyama, Takanori Domon, Wataru Nishie, Ken Natsuga, Yasuyuki Fujita, Riichiro Abe, Yoshimasa Kitagawa, Hiroshi Shimizu

    AMERICAN JOURNAL OF PATHOLOGY   174 ( 1 )   91 - 100   2009.1

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    DOI： 10.2353/ajpath.2009.080573

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  • 巨大潰瘍を形成したSLEの1例 Reviewed

    根本育恵, 松村和子, 村田純子, 藤田靖幸, 古崎章, 近藤真, 大西勝憲

    札幌社会保険総合病院医誌   17 ( 1 )   16-20   2008.12

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  • Leukaemic dissemination of Merkel cell carcinoma in a patient with systemic lupus erythematosus Reviewed

    Nemoto, I., Sato-Matsumura, K.C., Fujita, Y., Natsuga, K., Ujiie, H., Tomita, Y., Kato, N., Kondo, M., Ohnishi, K.

    Clinical and Experimental Dermatology   33 ( 3 )   270 - 272   2008.5

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    DOI： 10.1111/j.1365-2230.2007.02618.x

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  • Aggressive angiomyxoma of the vulva Reviewed

    Yasuyuki Fujita, Kazuko C. Sato-Matsumura, Sbuji Takahashi

    JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY   58 ( 2 )   S40 - S41   2008.2

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    DOI： 10.1016/j.jaad.2006.04.036

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  • Interleukin-1 beta and macrophage migration inhibitory factor (MIF) in dermal fibroblasts mediate UVA-induced matrix metalloproteinase-1 expression Reviewed

    Ayumi Honda, Riichiro Abe, Teruhiko Makino, Osamu Norisugi, Yasuyuki Fujita, Hirokazu Watanabe, Jun Nishihira, Yoichiro Iwakura, Sho-Ichi Yamagishi, Hiroshi Shimizu, Tadamichi Shimizu

    JOURNAL OF DERMATOLOGICAL SCIENCE   49 ( 1 )   63 - 72   2008.1

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  • Durable remission of Sezary syndrome after unrelated bone marrow transplantation by reduced-intensity conditioning Reviewed

    Kaoru Kahata, Satoshi Hashino, Mutsumi Takahata, Fumie Fujisawa, Takeshi Kondo, Sumiko Kobayashi, Yasuyuki Fujita, Hiroshi Shimizu, Masahiro Imamura, Masahiro Asaka

    ACTA HAEMATOLOGICA   120 ( 1 )   14 - 18   2008

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  • 帯状庖疹入院患者におけるDPC導入の臨床的検討 Reviewed

    藤田 靖幸, 根本 育恵, 松村 和子

    札幌社会保険総合病院医誌 = Journal of Sapporo Social Insurance General Hospital (JSSIGH)   16 ( 1 )   5 - 8   2007.12

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    当科に2003年3月から2005年9月までに帯状庖疹の診断で入院した86例を対象として、患者の疫学的特徴およびDPC導入前後における治療効果の検討を行った。患者の男女比は1:1.3で女性にやや多く、年齢別では70歳代が最多であった。DPC導入により疼痛の持続期間と非ステロイド抗炎症薬の使用期聞が有意に短縮した(p<0.05)。一方、入院期間と庖疹後神経痛の発症頻度に有意差はみられなかった。DPC導入により請求点数は減少したが、出来高診療報酬と比較して全例で平均6,492点の増収であった。

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  • 帯状疱疹入院患者におけるDPC導入の臨床的検討 Reviewed

    藤田靖幸, 根本育恵, 松村和子

    札幌社会保険総合病院医誌   16 ( 1 )   5-8   2007.12

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  • Transient acantholytic dermatosis associated with B symptoms of follicular lymphoma [3] Reviewed

    Y. Fujita, K. C. Sato-Matsumura, K. Ohnishi

    Clinical and Experimental Dermatology   32 ( 6 )   752 - 754   2007.11

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    DOI： 10.1111/j.1365-2230.2007.02471.x

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  • マンソン孤虫症の1例 Reviewed

    根本育恵, 松村和子, 藤田靖幸, 高橋秀史, 三好正浩, 八木欣平

    皮膚科の臨床   49 ( 11 )   1327-1329 - 1329   2007.10

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  • Angiogenesis and metastasis inhibitors for the treatment of malignant melanoma Reviewed

    Riichiro Abe, Yasuyuki Fujita, Sho-ichi Yamagishi

    MINI-REVIEWS IN MEDICINAL CHEMISTRY   7 ( 6 )   649 - 661   2007.6

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  • Tumour-like muscular sarcoidosis Reviewed

    I. Nemoto, T. Shimizu, Y. Fujita, Y. Tateishi, Y. Tsuji-Abe, H. Shimizu

    CLINICAL AND EXPERIMENTAL DERMATOLOGY   32 ( 3 )   298 - 300   2007.5

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    DOI： 10.1111/j.1365-2230.2007.02371.x

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  • 北海道でヒトから検出されたマンソン孤虫2例について Reviewed

    八木欣平, 三好正浩, 松村和子, 根本育恵, 藤田靖幸, 高橋秀史, 岡安健至, 藤田昌宏, 奥祐三郎, 影井昇

    Clin Parasitol   17 ( 1 )   94-96   2007.1

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  • Transverse leukonychia (Mees' lines) associated with pleural empyema Reviewed

    Y. Fujita, K. C. Sato-Matsumura, I. Doi, K. Takaoka

    Clinical and Experimental Dermatology   32 ( 1 )   127 - 128   2007.1

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    DOI： 10.1111/j.1365-2230.2006.02178.x

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  • CTACK/CCL27 accelerates skin regeneration via accumulation of bone marrow-derived keratinocytes Reviewed

    Daisuke Inokuma, Riichiro Abe, Yasuyuki Fujita, Mikako Sasaki, Akihiko Shibaki, Hideki Nakamura, James R. McMillan, Tadamichi Shimizu, Hiroshi Shimizu

    STEM CELLS   24 ( 12 )   2810 - 2816   2006.12

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    DOI： 10.1634/stemcells.2006-0264

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  • Hereditary Hemorrhagic Telangiectasia Reviewed

    FUJITA YASUYUKI, MATSUMURA KAZUKO, SATO NANA

    皮膚科の臨床   48 ( 9 )   1177-1180 - 1180   2006.9

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  • Trichomycosis Axillaris Reviewed

    FUJITA YASUYUKI, MATSUMURA KAZUKO, MURATA JUNKO, SATO NANA

    皮膚科の臨床   48 ( 8 )   1024-1025   2006.8

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  • A case of idiopathic Addison's disease with hyperpigmentation as the initial clinical manifestation Reviewed

    FUJITA YASUYUKI, MATSUMURA KAZUKO, MURATA JUNKO, YOSHIDA MASAHIRO, WADA NORIO

    臨床皮膚科   60 ( 8 )   690-693 - 693   2006.7

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    DOI： 10.11477/mf.1412100968

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  • 潰瘍性大腸炎患者に発症した結節性紅斑 Reviewed

    佐藤那奈, 藤田靖幸, 松村和子, 村田純子, 岸本篤人, 高橋秀史

    札幌社会保険総合病院医誌   15 ( 1 )   19-22 - 22   2006.7

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  • BCG副反応と思われる2乳児例 Reviewed

    高塚望, 柳内聖香, 伊藤希美, 宇加江進, 藤田靖幸, 松村和子, 井藤達也, 竹本功

    札幌社会保険総合病院医誌   15 ( 1 )   15-18 - 18   2006.7

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  • Juvenile Onset Sjoegren's Syndrome Diagnosed from Annular Erythema Reviewed

    FUJITA YASUYUKI, MATSUMURA KAZUKO, MURATA JUNKO, KURODA TSUTOMU, UKAE SUSUMU

    皮膚科の臨床   48 ( 7 )   909-913 - 913   2006.7

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  • Nail dystrophy and blisters as sole manifestations in myeloma-associated amyloidosis Reviewed

    Y Fujita, Y Tsuji-Abe, KC Sato-Matsumura, M Akiyama, H Shimizu

    JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY   54 ( 4 )   712 - 714   2006.4

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    DOI： 10.1016/j.jaad.2005.12.031

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  • Two cases of folliculosebaceous cystic hamartoma Reviewed

    S Tanimura, K Arita, F Iwao, M Kasai, Y Fujita, H Kawasaki, R Abe, D Sawamura, T Kimura, H Shimizu

    CLINICAL AND EXPERIMENTAL DERMATOLOGY   31 ( 1 )   68 - 70   2006.1

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    DOI： 10.1111/j.1365-2230.2005.01974.x

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  • Mycosis Fungoides with Pulmonary Involvement Reviewed

    MASHIKO MAKI, ARITA KEN, MORIUCHI REINE, FUJITA YASUYUKI, ABE RIICHIRO, KAWASHIMA TOSHIMITSU, SHIMIZU HIROSHI

    皮膚科の臨床   47 ( 12 )   1789-1793   2005.11

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  • Two cases of atypical membranous aplasia cutis with hair collar sign: one with dermal melanocytosis, and the other with naevus flammeus Reviewed

    Y Fujita, K Yokota, M Akiyama, S Machino, D Inokuma, K Arita, C Kimura, H Shimizu

    CLINICAL AND EXPERIMENTAL DERMATOLOGY   30 ( 5 )   497 - 499   2005.9

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    DOI： 10.1111/j.1365-2230.2005.01821.x

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  • A case of actinomycosis of the lower lip casually related to topical tacrolimus treatment Reviewed

    FUJITA YASUYUKI, YOKOTA KOICHI, SHIMIZU HIROSHI

    臨床皮膚科   59 ( 1 )   17-19 - 19   2005.1

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    DOI： 10.11477/mf.1412100003

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  • A case of chronic urticaria associated with autoimmune thyroid disease (Grave disease). Reviewed

    FUJITA YASUYUKI, SHIMIZU TADAMICHI, SHIMIZU HIROSHI

    ホルモンと臨床   52 ( 12 )   1219-1221 - 1221   2004.12

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  • Pigmentation localized on the philtra: A case strogly suspected of fixed drug eruption induced by Alosenn Reviewed

    FUJITA YASUYUKI, SAWAMURA DAISUKE, SHIMIZU HIROSHI

    臨床皮膚科   58 ( 8 )   635-637 - 637   2004.7

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    DOI： 10.11477/mf.1412100749

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  • A case of interstitial granulomatous drug reaction due to sennoside Reviewed

    Y Fujita, T Shimizu, H Shimizu

    BRITISH JOURNAL OF DERMATOLOGY   150 ( 5 )   1035 - 1037   2004.5

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    DOI： 10.1111/j.0007-0963.2004.05916.x

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  • Erythema Multiforme Possibly Associated with Human Parvovirus B19 Infection Reviewed

    FUJITA YASUYUKI, MATSUMURA KAZUKO, TATEISHI YASUKI, SHIMIZU HIROSHI

    皮膚科の臨床   46 ( 3 )   507-509 - 509   2004.3

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  • Contact dermatitis due to eugenol used to treat oral lichen planus Reviewed

    Y Fujita, T Shimizu, W Nishie, H Shimizu

    CONTACT DERMATITIS   48 ( 5 )   285 - 285   2003.5

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Books

MISC

  • Clinical and histopathological features of eosinophilic annular erythema: differentiation from Wells syndrome. Invited

    中里信一, 藤田靖幸

    月刊皮膚科   7 ( 4 )   2025

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  • Donor Muse Cell Treatment Without HLA-Matching Tests and Immunosuppressant Treatment. Invited Reviewed International journal

    Shinya Minatoguchi, Yasuyuki Fujita, Kuniyasu Niizuma, Teiji Tominaga, Toru Yamashita, Koji Abe, Mari Dezawa

    Stem cells translational medicine   2024.4

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    The strength of stem cell therapy is the regeneration of tissues by synergistic pleiotropic effects. Among many stem cell types, mesenchymal stem cells (MSCs) that are comprised of heterogenous population are widely used for clinical applications with the expectation of pleiotropic bystander effects. Muse cells are pluripotent-like/macrophage-like stem cells distributed in the bone marrow, peripheral blood, and organ connective tissues as cells positive for the pluripotent surface marker stage-specific-embryonic antigen -3. Muse cells comprise ~1% to several percent of MSCs. While Muse cells and MSCs share several characteristics, such as mesenchymal surface marker expression and their bystander effects, Muse cells exhibit unique characteristics not observed in MSCs. These unique characteristics of Muse cells include selective homing to damaged tissue after intravenous injection rather than being trapped in the lung like MSCs, replacement of a wide range of damaged/apoptotic cells by differentiation through phagocytosis, and long-lasting immunotolerance for donor cell use. In this review, we focus on the basic properties of Muse cells clarified through preclinical studies and clinical trials conducted by intravenous injection of donor-Muse cells without HLA-matching tests or immunosuppressant treatment. MSCs are considered to differentiate into osteogenic, chondrogenic, and adipogenic cells, whereas the range of their differentiation has long been debated. Muse cells may provide clues to the wide-ranging differentiation potential of MSCs that are observed with low frequency. Furthermore, the utilization of Muse cells may provide a novel strategy for clinical treatment.

    DOI： 10.1093/stcltm/szae018

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  • Cutaneous adverse drug reaction in pregnancy and its treatment. Invited

    藤田靖幸, 阿部理一郎

    月刊皮膚科   6 ( 6 )   553 - 556   2024

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  • Cultured epidermal autografts for the treatment of epidermolysis bullosa Invited Reviewed

    藤田靖幸

    臨床皮膚科   74 ( 5 )   2020

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  • Development of cell-based therapies for epidermolysis bullosa Invited Reviewed

    藤田靖幸

    再生医療   17 ( 3 )   2018

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  • Clinical Approaches Toward Tumor Angiogenesis: Past, Present and Future Invited Reviewed

    Yasuyuki Fujita, Riichiro Abe, Hiroshi Shimizu

    CURRENT PHARMACEUTICAL DESIGN   14 ( 36 )   3820 - 3834   2008.12

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    DOI： 10.2174/138161208786898680

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  • 先天性表皮水疱症の最近の進歩 進化しつつある表皮水疱症の治療 Invited

    藤田 靖幸

    日本臨床皮膚科医会雑誌   42 ( 5 )   657 - 661   2025.9

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    Authorship：Lead author,　Last author,　Corresponding author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)   Publisher：(一社)日本臨床皮膚科医会  

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  • ツツガムシ病様の皮疹を呈したライム病の1例

    板本想太, 藤田靖幸, 織田晃大, 山賀三紗子, 清水聡子, 市川隆裕

    日本皮膚科学会雑誌   135 ( 1 )   2025

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  • 声 「アミロイド苔癬を疑った右肘の角化性局面」を読んで Reviewed

    藤田 靖幸

    皮膚病診療   46 ( 12 )   1125 - 1125   2024.12

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  • A case of polypoid nodule on the anterior chest. Invited

    Shinichi Nakazato, Yasuyuki Fujita, Takashi Anan, Hideyuki Ujiie, Utano Tomaru

    The 22nd Korean Society for Dermatopathology Meeting   2024.5

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  • バーチャルスライドでズバッと診断!皮膚病理演習【炎症編】Part3.水疱症・膿疱症・膠原病・肉芽腫症 Q15 全身に水疱をくり返す症例.診断は? Invited

    藤田靖幸

    Visual Dermatology   23 ( 7 )   675,639 - 676,639   2024

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  • バーチャルスライドでズバッと診断!皮膚病理演習【炎症編】Part4.感染症 Q19 手足にくり返す水疱.診断は? Invited

    藤田靖幸

    Visual Dermatology   23 ( 7 )   683,643 - 684,643   2024

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  • 当院におけるdermatitis neglectaの検討

    島野麻由奈, 藤田靖幸, 山賀三紗子, 葭本倫大, 清水聡子

    日本皮膚科学会雑誌   134 ( 6 )   2024

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  • 皮膚所見を契機に診断されたSjoegren症候群合併Cronkhite-Canada症候群の1例

    織田晃央, 藤田靖幸, 板本想太, 清水聡子, 小野雄司, 中埜渡美佳, 羽賀直哉

    日本皮膚科学会雑誌   134 ( 9 )   2024

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  • CK上昇を伴う一過性の筋炎症状を合併した壊疽性膿皮症の1例

    清水聡子, 葭本倫大, 山賀三紗子, 島野麻由奈, 佃曜子, 高橋士郎, 片岡浩, 藤田靖幸

    日本皮膚科学会雑誌   134 ( 5 )   2024

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  • 限局性強皮症様皮下脂肪織炎様T細胞性リンパ腫の1例

    得地景子, 柳輝希, 稲村衣美, 川村拓也, 瀬尾拓志, 藤田靖幸, 中川雅夫, 笠原郁美, 松野吉宏, 氏家英之

    日本皮膚科学会雑誌   134 ( 5 )   2024

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  • Congenital self-healing Langerhans cell histiocytosisの1例

    葭本倫大, 藤田靖幸, 山賀三紗子, 清水聡子, 東山望

    日本皮膚科学会雑誌   134 ( 1 )   2024

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  • コバルトに対するI型アレルギーが推測された1例

    織田晃央, 藤田靖幸, 板本想太, 菅裕司, 清水聡子

    日本皮膚免疫アレルギー学会総会学術大会プログラム・抄録集   54th   2024

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  • 胸骨上に生じた皮膚腺病の1例

    葭本倫大, 藤田靖幸, 島野麻由奈, 山賀三紗子, 清水聡子

    日本皮膚科学会雑誌   134 ( 6 )   2024

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  • 水痘ワクチン初回接種部位から帯状疱疹様皮疹を生じた乳児の1例

    須貝達朗, 藤田靖幸, 稲村衣美, 清水聡子, 山田壮一, 福士秀悦, 畠山欣也

    日本皮膚科学会雑誌   133 ( 2 )   2023

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  • ペムブロリズマブ投与を契機に発症したと考えられた扁平苔癬の1例

    平野瑶子, 藤田靖幸, 稲村衣美, 清水聡子, 中村路夫, 山口響子

    日本皮膚科学会雑誌   133 ( 2 )   2023

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  • 皮膚爬行症の4例

    山賀三紗子, 藤田靖幸, 葭本倫大, 清水聡子, 田中美緒, 丸山治彦

    日本皮膚科学会雑誌   133 ( 12 )   2023

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  • 腫瘍随伴性天疱瘡の1例

    山賀三紗子, 藤田靖幸, 葭本倫大, 平野瑶子, 稲村衣美, 清水聡子, 金田聡門

    日本皮膚科学会雑誌   133 ( 9 )   2023

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  • plantar subcutaneous nodule

    稲村衣美, 稲村衣美, 藤田靖幸, 藤田靖幸, 平野瑶子, 石井保志, 辻隆裕, 長谷川匡, 清水聡子

    日本皮膚病理組織学会抄録集   39th   2023

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  • 難治性acne conglobataの治療経験

    清水聡子, 稲村衣美, 平野瑤子, 竹崎俊一郎, 藤田靖幸

    日本皮膚科学会雑誌   133 ( 5 )   2023

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  • 壊疽性膿皮症患者に生じた急性下肢虚血の1例

    須貝達朗, 須貝達朗, 藤田靖幸, 稲村衣美, 稲村衣美, 鈴木理穂, 檀浦裕, 檀浦裕, 清水聡子

    日本フットケア・足病医学会年次学術集会プログラム・抄録集   4th   2023

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  • Diffuse large B-cell lymphomaの治療後瘢痕部に発症した黄色肉芽腫の1例

    稲村衣美, 藤田靖幸, 平野瑶子, 清水聡子, 山本聡, 島野麻由奈, 夏賀健

    日本皮膚科学会雑誌   133 ( 3 )   2023

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  • エンホルツマブベドチンによる皮膚障害の3例

    平野瑶子, 藤田靖幸, 稲村衣美, 清水聡子, 三浪圭太, 田中博

    日本皮膚科学会雑誌   133 ( 3 )   2023

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  • 片側性眼瞼腫脹を契機に診断に至ったSjoegren症候群の1例

    平野瑶子, 藤田靖幸, 稲村衣美, 須貝達朗, 清水聡子, 清水美穂, 近藤真

    日本皮膚科学会雑誌   132 ( 12 )   2022

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  • COVID-19関連皮疹の3例

    須貝達朗, 藤田靖幸, 稲村衣美, 真屋由佳, 清水聡子, 児玉文宏, 永坂敦, 金田聡門, 片岡浩

    日本皮膚科学会雑誌   132 ( 12 )   2022

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  • 新生児ループスの2例

    平野瑶子, 藤田靖幸, 稲村衣美, 水上卓哉, 清水聡子, 池田雅彦, 佐藤逸美

    日本皮膚科学会雑誌   132 ( 12 )   2022

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  • 透析中の乾癬患者に対して当科で生物学的製剤を施行している4例

    稲村衣美, 藤田靖幸, 須貝達朗, 清水聡子

    日本皮膚科学会雑誌   132 ( 12 )   2022

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  • MEFV遺伝子変異を伴った難治性neutrophilic urticariaの1例

    稲村衣美, 藤田靖幸, 須貝達朗, 清水聡子, 冨田智子

    日本皮膚科学会雑誌   132 ( 12 )   2022

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  • 急性リンパ性白血病の診断契機となったネコ咬傷の1例

    稲村衣美, 藤田靖幸, 平野瑶子, 清水聡子, 笠原郁美

    日本皮膚科学会雑誌   132 ( 12 )   2022

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  • 低亜鉛血症を伴う難治性皮膚病変に対して酢酸亜鉛水和物が奏功した4例

    稲村衣美, 藤田靖幸, 須貝達朗, 清水聡子

    日本皮膚科学会雑誌   132 ( 12 )   2022

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  • DNA複製ストレス反応の変化が毛孔性紅色粃糠疹5型の自然治癒現象を誘導する

    宮内俊成, 鈴木翔多朗, 竹田真依, TENG Peh Jin, 相庭昌之, 夏賀健, 藤田靖幸, 清水宏, 氏家英之, 坂本泰子, 武市拓也, 秋山真志, 乃村俊史

    日本皮膚科学会雑誌   132 ( 12 )   2022

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  • 【聞きなれない病名-2021】eosinophilic annular erythema Invited Reviewed

    中里 信一, 藤田 靖幸

    皮膚病診療   43 ( 1 )   12 - 16   2021.1

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  • 旋毛虫症の診断に至った中毒疹の1例

    真屋由佳, 藤田靖幸, 宮本航大, 水上卓哉, 清水聡子, 児玉文宏, 森嶋康之, 杉山広, 長野功

    日本皮膚科学会雑誌   131 ( 3 )   2021

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  • 膵癌の進行に伴って再燃し関節痛を合併したpancreatic panniculitisの1例

    宮本航大, 藤田靖幸, 真屋由佳, 中村路夫, 清水聡子

    西日本皮膚科   83 ( 3 )   2021

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  • Stevens-Johnson症候群(SJS)/中毒性表皮壊死症(TEN)の新規病態メカニズムと新規早期診断マーカーの有用性

    木下真直, 小川陽一, 島田眞路, 川村龍吉, 濱菜摘, 長谷川瑛人, 阿部理一郎, 氏家韻欣, 藤田靖幸, 中島沙恵子, 野村尚史, 高橋勇人, 水川良子

    日本皮膚科学会雑誌   131 ( 8 )   2021

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  • クマ肉摂食後に皮疹を生じた旋毛虫症の1集団

    真屋由佳, 藤田靖幸, 宮本航大, 水上卓哉, 清水聡子, 児玉文宏, 森嶋康之, 杉山広, 長野功

    日本皮膚科学会雑誌   131 ( 2 )   2021

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  • 膵癌の発見契機となったpancreatic panniculitisの1例

    真屋由佳, 藤田靖幸, 宮本航大, 清水聡子, 吹野良, 小野雄司

    日本皮膚科学会雑誌   131 ( 3 )   2021

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  • 帝王切開創部に生じた壊疽性膿皮症の1例

    水上卓哉, 藤田靖幸, 真屋由佳, 清水聡子, 川端公輔, 齋藤典子, 堀内勝己

    日本皮膚科学会雑誌   130 ( 12 )   2020

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  • 腋窩の副乳に生じた偽血管腫様過形成の1例

    真屋由佳, 藤田靖幸, 宮本航大, 清水聡子, 西村真智子

    日本皮膚科学会雑誌   130 ( 12 )   2020

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  • Epitope spreading現象によって抗BP180 NC16a抗体が陽転化したdipeptidyl peptidase-IV阻害薬関連水疱性類天疱瘡の3例

    眞井 洋輔, 西江 渉, 泉 健太郎, 葭本 倫大, 森田 裕介, 渡邉 美佳, 豊永 愛恋, 氏家 英之, 岩田 浩明, 藤田 靖幸, 乃村 俊史, 松村 和子, 清水 聡子, 清水 宏

    加齢皮膚医学セミナー   2019.6

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  • クローン病に対してインフリキシマブ(IFX)の治療経過中に全身の膿疱性皮疹を生じた1例

    水上 卓哉, 藤田 靖幸, 眞井 翔子, 宮澤 元, 宮内 俊成, 村松 憲, 清水 宏, 桂田 武彦, 小林 仁

    日本皮膚科学会雑誌   129 ( 3 )   393 - 393   2019.3

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  • 表皮水疱症の症状と治療 Invited Reviewed

    高島翔太, 高島翔太, 藤田靖幸

    月刊難病と在宅ケア   25 ( 4 )   2019

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  • Epitope spreading現象によって抗BP180NC16a抗体が陽転化したdipeptidyl peptidase-IV阻害薬関連水疱性類天疱瘡の3例

    眞井洋輔, 西江渉, 泉健太郎, 葭本倫大, 森田裕介, 渡邉美佳, 豊永愛恋, 氏家英之, 岩田浩明, 藤田靖幸, 乃村俊史, 松村和子, 清水聡子, 清水宏

    加齢皮膚医学セミナー   14 ( 1 )   2019

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  • 私の治療 ジベルバラ色粃糠疹 Invited

    藤田靖幸

    週刊日本医事新報   ( 4975 )   2019

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  • CRISPR/Cas9システムを用いた劣性栄養障害型表皮水疱症(RDEB)の治療法の開発

    高島翔太, 乃村俊史, 氏家英之, 夏賀健, 岩田浩明, 中村秀樹, 清水宏, 新熊悟, 阿部理一郎, 藤田靖幸

    日本皮膚科学会雑誌   129 ( 9 )   2019

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  • 様々な幹細胞を用いた表皮水疱症の再生治療戦略 Invited

    新熊悟, 藤田靖幸

    日本皮膚科学会雑誌   129 ( 5 )   2019

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  • 抗デスモグレイン3抗体がCLEIAで陰性、ELISAで陽性となった尋常性天疱瘡の1例

    眞井 洋輔, 氏家 英之, 西村 真智子, 古賀 浩嗣, 真屋 由佳, 得地 景子, 藤田 靖幸, 三河 洋平, 清水 宏

    西日本皮膚科   2018.6

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  • 経過中ぶどう膜炎を併発した尋常性乾癬の小児の1例

    宮澤 元, 藤田 靖幸, 村松 憲, 岩田 浩明, 南場 研一, 保科 大地, 清水 宏

    日本皮膚科学会雑誌   2018.4

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  • 【心に残る症例-40周年記念特別号】 <臨床例> white fibrous papulosis of the neck Invited

    高島 翔太, 藤田 靖幸, 清水 宏

    皮膚病診療   40 ( 1 )   47 - 50   2018.1

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  • 小児線状強皮症に対してシクロスポリン内服が有効であった3例

    眞井 翔子, 藤田 靖幸, 宮内 俊成, 藤村 悠, 夏賀 健, 乃村 俊史, 西江 渉, 清水 宏, 小野寺 智洋, 岡 敏明

    日本皮膚科学会雑誌   2018.1

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  • Epitope spreading現象によって抗BP180 NC16a抗体が陽性となったdipeptidyl peptidase-IV阻害薬関連水疱性類天疱瘡の3例

    眞井洋輔, 西江渉, 泉健太郎, 葭本倫大, 森田裕介, 渡邉美佳, 豊永愛恋, 氏家英之, 岩田浩明, 藤田靖幸, 乃村俊史, 清水宏, 松村和子, 清水聡子

    日本皮膚科学会雑誌   128 ( 8 )   2018

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  • クローン病に対するインフリキシマブ(IFX)の治療経過中に毛包炎型と多形紅斑型の薬疹を併発した1例

    水上卓哉, 藤田靖幸, 眞井翔子, 宮澤元, 宮内俊成, 村松憲, 清水宏, 桂田武彦, 小林仁

    日本皮膚科学会雑誌   128 ( 12 )   2018

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  • 足底に発生した複合型母斑と悪性黒色腫のダーモスコピーによる鑑別点

    前田拓哉, 秦洋郎, 柳輝希, 今福恵輔, 北村真也, 本間英里奈, 藤田靖幸, 清水宏

    日本臨床皮膚科医会雑誌   35 ( 2 )   2018

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  • 乾癬104例における真皮好酸球浸潤の検討

    中里信一, 中里信一, 阿南隆, 藤田靖幸, 清水宏

    日本皮膚病理組織学会抄録集   34th   2018

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  • 抗デスモグレイン3抗体がCLEIAで陰性,ELISAで陽性となった尋常性天疱瘡の1例

    眞井洋輔, 氏家英之, 西村真智子, 古賀浩嗣, 真屋由佳, 得地景子, 藤田靖幸, 三河洋平, 清水宏

    西日本皮膚科   80 ( 3 )   2018

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  • CLEIAで抗デスモグレイン3抗体が陰性となった尋常性天疱瘡の1例

    眞井洋輔, 氏家英之, 西村真智子, 真屋由佳, 得地景子, 藤田靖幸, 岩田浩明, 清水宏, 三河洋平, 古賀浩嗣

    日本皮膚科学会雑誌   128 ( 1 )   2018

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  • Chromosomal inversions as a hidden disease-modifying factor

    T. Nomura, S. Suzuki, T. Miyauchi, M. Takeda, Y. Fujita, W. Nishie, M. Akiyama, H. Shimizu

    JOURNAL OF INVESTIGATIVE DERMATOLOGY   2017.10

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  • Two families of nail-patella syndrome with novel splice site mutations in the LMX1B gene

    S. Shinkuma, H. Nakamura, S. Takashima, T. Nomura, Y. Fujita, S. Hasegawa, K. Matsumura, H. Shimizu, R. Abe

    JOURNAL OF INVESTIGATIVE DERMATOLOGY   2017.10

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  • 膿疱性乾癬とMikulicz病が合併した1例

    宮澤 元, 藤田 靖幸, 岩田 浩明, 清水 宏, 石川 康暢, 西尾 妙織, 石嶋 漢, 新明 康弘

    日本皮膚科学会雑誌   2017.8

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  • アダリムマブ投与中に皮下血腫を生じた乾癬性関節炎の1例

    真屋 由佳, 藤田 靖幸, 中山 ちひろ, 北村 真也, 秦 洋郎, 清水 宏, 有田 賢

    日本皮膚科学会雑誌   2017.8

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  • Matrix-assisted laser desorption ionization time-of-flight mass spectrometry(MALDI-TOF/MS)が診断に有用であったMicrosporum canis感染症の家族例

    山口 泰之, 藤田 靖幸, 白戸 貴久, 新熊 悟, 夏賀 健, 乃村 俊史, 清水 宏, 福元 達也

    日本皮膚科学会雑誌   2017.8

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  • Reticulated acanthoma with sebaceous differentiationの1例

    中里 信一, 柳 輝希, 高島 有香, 北村 真也, 秦 洋郎, 藤田 靖幸, 阿南 隆, 松村 哲理, 清水 宏

    西日本皮膚科   79 ( 3 )   314 - 314   2017.6

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  • ENPP1に新規ミスセンス変異を同定したCole病の1家系

    宮内 俊成, 乃村 俊史, 鈴木 翔多朗, 竹田 真依, 新熊 悟, 氏家 英之, 藤田 靖幸, 阿部 理一郎, 清水 宏

    日本皮膚科学会雑誌   2017.5

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  • Gene-edition targeting mutation site recovers null-expression of type VII collagen caused by frameshift mutation via non-homologous end joining in Recessive Dystrophic Epidermolysis Bullosa

    S. Takashima, S. Shinkukma, Y. Fujita, T. Nomura, H. Ujiie, R. Abe, H. Shimizu

    JOURNAL OF INVESTIGATIVE DERMATOLOGY   2017.5

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  • 色素異常を伴う掌蹠角化症の1家系

    宮内 俊成, 乃村 俊史, 鈴木 翔多朗, 竹田 真依, 新熊 悟, 氏家 英之, 藤田 靖幸, 清水 宏, 阿部 理一郎

    角化症研究会記録集   2017.3

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  • 新規ケラチン1遺伝子変異によるichthyosis with confettiの1家系

    鈴木 翔多朗, 乃村 俊史, 宮内 俊成, 竹田 真依, 中村 秀樹, 新熊 悟, 藤田 靖幸, 清水 宏, 秋山 真志

    角化症研究会記録集   2017.3

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  • 稀少難治性皮膚疾患に関する調査研究 「表皮水疱症の診療ガイドライン作成」

    玉井克人, 池田志斈, 清水宏, 澤村大輔, 藤田靖幸, 新熊悟, 赤坂英二郎, 久保亮治, 石河晃

    稀少難治性皮膚疾患に関する調査研究 平成28年度 総括・分担研究報告書(Web)   2017

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  • Establishment of keratinocytes derived transgene-free induced pluripotent stem cells from recessive dystrophic epidermolysis bullosa patients

    W. Matsumura, Y. Fujita, S. Shinkuma, I. Ujiie, C. Nakayama, K. Matsumoto, T. Nomura, R. Abe, H. Shimizu

    AUSTRALASIAN JOURNAL OF DERMATOLOGY   2016.11

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  • A novel mechanism of skin reaction related to Helicobacter pylori treatment

    T. Ito, H. Ujiie, Y. Fujita, H. Shimizu, R. Abe

    JOURNAL OF INVESTIGATIVE DERMATOLOGY   2016.9

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  • 広範囲に皮疹を生じた長島型掌蹠角化症の1例

    宮内 俊成, 乃村 俊史, 鈴木 翔多朗, 大口 由香, 山口 泰之, 新熊 悟, 夏賀 健, 藤田 靖幸, 清水 宏

    日本皮膚科学会雑誌   2016.8

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  • 前額部に限局してmulticentric Castleman diseaseの皮膚病変を認めた1例

    佐藤 一正, 新熊 悟, 秋野 愛, 乃村 俊史, 藤田 靖幸, 阿部 理一郎, 清水 宏

    日本皮膚科学会雑誌   2016.6

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  • Eosinophilic annular erythema 10例の臨床病理学的検討

    中里 信一, 藤田 靖幸, 新熊 悟, 乃村 俊史, 清水 宏

    日本皮膚病理組織学会抄録集   2016.6

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  • 病理学的に乾癬様の変化を呈した菌状息肉症の2例

    山口 泰之, 藤田 靖幸, 平田 悠, 西村 真智子, 夏賀 健, 清水 宏, 肥田 時征, 加藤 直子

    日本皮膚科学会雑誌   2016.6

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  • 長島型掌蹠角化症の1例

    宮内 俊成, 乃村 俊史, 鈴木 翔多朗, 山口 泰之, 夏賀 健, 藤田 靖幸, 清水 宏

    角化症研究会記録集   2016.3

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  • 固定性扁豆状角化症(Flegel病)の1例

    椎谷千尋, 月永一郎, 岩崎沙理, 藤田靖幸, 横関真由美

    日本皮膚科学会雑誌   126 ( 6 )   2016

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  • 顔面の腫瘤に対し電子線照射およびRePUVA療法が著効した腫瘤期菌状息肉症の1例

    葭本倫大, 藤田靖幸, 平田悠, 保科大地, 守内玲寧, 氏家英之, 清水宏, 井上哲也

    日本皮膚科学会雑誌   126 ( 7 )   2016

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  • 顔面の巨大な腫瘤に対し電子線照射およびRePUVA療法が著効した菌状息肉症の1例

    葭本倫大, 藤田靖幸, 平田悠, 保科大地, 守内玲寧, 氏家英之, 清水宏, 井上哲也

    日本皮膚科学会雑誌   126 ( 2 )   2016

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  • 前額部に限局してmulticentric Castleman diseaseの皮膚病変を認めた1例

    佐藤 一正, 新熊 悟, 秋野 愛, 乃村 俊史, 藤田 靖幸, 阿部 理一郎, 清水 宏

    日本皮膚科学会雑誌   2015.11

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  • 【実践 子ども皮膚科外来】 小児の水疱症

    藤田 靖幸

    Derma.   ( 236 )   111 - 122   2015.10

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  • 【各種難病の最新情報】 [第2部]乾癬の最新治療 生物学的製剤を中心に Invited

    藤田 靖幸

    難病と在宅ケア   21 ( 3 )   29 - 33   2015.6

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    Other Link： http://search.jamas.or.jp/link/ui/2015243093

  • RNA recognition motif of LEMD3 as a key player in the pathogenesis of Buschke-Ollendorff syndrome

    S. Takashima, Y. Fujita, S. Suzuki, N. Saito, T. Nomura, H. Shimizu

    JOURNAL OF INVESTIGATIVE DERMATOLOGY   135   S74 - S74   2015.5

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  • RAS/MAPK症候群の1例

    今福 恵輔, 乃村 俊史, 稲村 有香, 森田 裕介, 本間 英里奈, 山根 尚子, 藤田 靖幸, 阿部 理一郎, 清水 宏

    日本皮膚科学会雑誌   125 ( 6 )   1274 - 1274   2015.5

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  • 新規frame shift変異を認めたBuschke-Ollendorff症候群の1家系

    高島 翔太, 藤田 靖幸, 鈴木 翔多郎, 齋藤 奈央, 新熊 悟, 乃村 俊史, 清水 宏

    日本臨床皮膚科医会雑誌   2015.5

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  • Irritated seborrheic keratosisのダーモスコピー所見の検討

    北村 真也, 秦 洋郎, 今福 恵輔, 藤田 靖幸, 清水 宏

    日本皮膚科学会雑誌   125 ( 3 )   445 - 445   2015.3

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  • LEMD3遺伝子に新規フレームシフト変異を認めたBuschke-Ollendorff症候群の1家系

    高島 翔太, 藤田 靖幸, 鈴木 翔多朗, 齋藤 奈央, 新熊 悟, 乃村 俊史, 清水 宏

    日本皮膚科学会雑誌   2015.3

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  • RAS/MAPK症候群の1例

    今福 恵輔, 乃村 俊史, 稲村 有香, 森田 裕介, 本間 英里奈, 山根 尚子, 藤田 靖幸, 阿部 理一郎, 清水 宏

    日本皮膚科学会雑誌   125 ( 3 )   447 - 447   2015.3

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  • 結節性強皮症の1例

    中里 信一, 乃村 俊史, 山根 尚子, 新熊 悟, 夏賀 健, 藤田 靖幸, 有田 賢, 竹中 ちひろ, 清水 宏

    日本皮膚科学会雑誌   2015.1

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  • 頭部にfibrokeratomaが多発した尋常性乾癬の1例

    椎谷千尋, 野村友希子, 藤田靖幸, 中山ちひろ, 清水宏

    日本乾癬学会学術大会プログラム・抄録集   30th   2015

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  • Treatment of congenital severe skin disorders with hematopoietic stem cells obtained from induced pluripotent stem cells (iPSCs)

    23   105 - 110   2015

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  • 深部静脈血栓症を契機に診断された不全型血管ベーチェット病の1例

    村松憲, 猪熊大輔, 月永一郎, 阿部智絵, 白井真也, 福田直樹, 藤田靖幸, 清水宏

    日本皮膚科学会雑誌   125 ( 3 )   2015

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  • 皮疹を契機に骨髄異形成症候群の診断に至ったSweet症候群の1例

    森田裕介, 野村友希子, 伊東孝政, 乃村俊史, 藤田靖幸, 西江渉, 清水宏, 杉田純一, 菊池敏郎

    日本皮膚科学会雑誌   124 ( 10 )   1929 - 1930   2014.9

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  • Striking intrafamilial phenotypic variability in loricrin keratoderma

    S. Suzuki, T. Nomura, Y. Fujita, W. Nishie, M. Akiyama, H. Shimizu

    JOURNAL OF INVESTIGATIVE DERMATOLOGY   134   S62 - S62   2014.9

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  • 【水疱症の治療 最前線】 先天性表皮水疱症の治療 Invited Reviewed

    藤田 靖幸

    Derma.   ( 222 )   39 - 44   2014.9

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  • 抗デスモグレイン自己抗体を認めた口腔扁平上苔癬の2例

    村松 憲, 西江 渉, 夏賀 健, 藤田 靖幸, 岩田 浩明, 清水 宏, 山田 珠希, 山下 映美, 浅香 卓哉

    日本皮膚科学会雑誌   124 ( 10 )   1946 - 1946   2014.9

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  • Highly prevalent SERPINB7 founder mutation causes pseudodominant inheritance pattern in Nagashima-type palmoplantar keratosis

    O. Mizuno, T. Nomura, S. Suzuki, M. Takeda, Y. Ohguchi, Y. Fujita, W. Nishie, K. Sugiura, M. Akiyama, H. Shimizu

    JOURNAL OF INVESTIGATIVE DERMATOLOGY   134   S47 - S47   2014.9

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  • 皮疹を契機に骨髄異形成症候群の診断に至ったSweet症候群の1例

    森田 裕介, 野村 友希子, 伊東 孝政, 乃村 俊史, 藤田 靖幸, 西江 渉, 杉田 純一, 菊池 敏郎, 清水 宏

    西日本皮膚科   76 ( 3 )   274 - 274   2014.6

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  • 顔面に播種状に生じたMycobacterium chelonae感染症の1例

    村松 憲, 乃村 俊史, 伊東 孝政, 濱出 洋平, 平田 悠, 藤田 靖幸, 阿部 理一郎, 清水 宏, 松本 光博

    西日本皮膚科   76 ( 3 )   287 - 287   2014.6

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  • Keratinocyte death in severe cutaneous adverse drug reactions is mediated by necroptosis pathway of annexin A1/FPR1 interaction

    N. Saito, T. Yanagi, S. Shinkuma, A. Suto, Y. Fujita, S. Suzuki, T. Nomura, H. Nakamura, H. Shimizu, R. Abe

    JOURNAL OF INVESTIGATIVE DERMATOLOGY   134   S3 - S3   2014.5

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  • 非特異的紅斑を伴った未分化大細胞リンパ腫の2例

    坂田真由子, 藤田靖幸, 辻脇真澄, 柴景子, 大宮若菜, 齋藤奈央, 大口由香, 清水宏

    日本皮膚科学会雑誌   124 ( 9 )   2014

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  • Thymoma-associated multiorgan autoimmunityの1例

    村松憲, 猪熊大輔, 月永一郎, 伊藤健一郎, 西浦洋一, 藤田靖幸

    日本皮膚科学会雑誌   124 ( 11 )   2014

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  • 顔面の腫脹から診断に至った皮下脂肪織炎様T細胞性リンパ腫(subcutaneous panniculitis-like T-cell lymphoma:SPTCL)の1例

    中里 信一, 藤田 靖幸, 古口 華子, 長谷部 育恵, 西江 渉, 清水 宏, 白鳥 聡一, 近藤 健

    日本皮膚科学会雑誌   123 ( 8 )   1539 - 1539   2013.7

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  • 顔面に播種状に生じたMycobacterium chelonae感染症の1例

    村松 憲, 乃村 俊史, 伊東 孝政, 濱出 洋平, 平田 悠, 藤田 靖幸, 阿部 理一郎, 清水 宏, 松本 光博

    日本皮膚科学会雑誌   123 ( 8 )   1549 - 1549   2013.7

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  • アレルゲン除去ミルクにより生じたビオチン欠乏症の1例

    伊東 孝政, 西江 渉, 藤田 靖幸, 阿部 理一郎, 清水 宏

    日本皮膚科学会雑誌   123 ( 8 )   1543 - 1543   2013.7

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  • 皮疹から診断に至った小児皮膚筋炎の1例

    足立 真紀, 藤田 靖幸, 中里 信一, 西江 渉, 清水 宏, 小林 一郎, 小林 仁

    日本皮膚科学会雑誌   123 ( 8 )   1549 - 1549   2013.7

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  • A Method for Intravital Monitoring of Human Cells Using a Far-Red Luminescent Probe in Graft-Versus-Host Disease Model Mice (vol 133, pg 841, 2013)

    Hongjiang Qiao, Riichiro Abe, Nao Saito, Yasuyuki Fujita, Inkin Hayashi-Ujiie, Gang Wang, Sanae Haga, Chun Wu, Yoshihiro Ohmiya, Michitaka Ozaki, Hiroshi Shimizu

    JOURNAL OF INVESTIGATIVE DERMATOLOGY   133 ( 6 )   1692 - 1692   2013.6

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  • 顔面の腫脹から診断に至った皮下脂肪織炎様T細胞性リンパ腫(SPTCL)の1例

    中里 信一, 藤田 靖幸, 古口 華子, 長谷部 育恵, 西江 渉, 清水 宏, 白鳥 聡一, 近藤 健

    日本皮膚科学会雑誌   123 ( 6 )   1098 - 1098   2013.5

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  • The mitochondrial fusion proteins Mfn1 and Mfn2 are involved in keratinization

    A. Suto, R. Abe, N. Saito, S. Suzuki, Y. Fujita, T. Nomura, H. Nakamura, H. Shimizu

    JOURNAL OF INVESTIGATIVE DERMATOLOGY   133   S109 - S109   2013.5

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  • A novel necroptosis pathway of annexin A1/FPR1 interaction in severe cutaneous adverse drug reactions

    N. Saito, H. Qiao, T. Yanagi, S. Shinkuma, A. Suto, Y. Fujita, S. Suzuki, T. Nomura, H. Nakamura, H. Shimizu, R. Abe

    JOURNAL OF INVESTIGATIVE DERMATOLOGY   133   S28 - S28   2013.5

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  • アレルゲン除去ミルクにより生じたビオチン欠乏症の1例

    伊東 孝政, 西江 渉, 藤田 靖幸, 阿部 理一郎, 清水 宏

    日本皮膚科学会雑誌   123 ( 6 )   1092 - 1092   2013.5

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  • 弾性線維性仮性黄色腫における特徴的なダーモスコピー所見

    守内 玲寧, 西江 渉, 新熊 悟, 藤田 靖幸, 有田 賢, 清水 宏

    日本皮膚科学会雑誌   123 ( 4 )   451 - 451   2013.4

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  • 右側胸部の皮下結節

    平田 悠, 有田 賢, 山根 尚子, 新熊 悟, 藤田 靖幸, 清水 宏

    日本皮膚病理組織学会会誌   28 ( 2 )   81 - 81   2013.3

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  • 重症遺伝性皮膚疾患に対する新規細胞療法の開発

    藤田靖幸

    上原記念生命科学財団研究報告集(CD-ROM)   27   2013

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  • 成人型肥満細胞症の2例

    中里信一, 藤田靖幸, 氏家英之, 西江渉, 阿部理一郎, 清水宏

    日本皮膚科学会雑誌   123 ( 8 )   2013

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  • 薬疹の今 SJS/TENを含めた重症型薬疹の早期診断法について Invited

    藤田靖幸, 阿部理一郎

    Mon Book Derma   ( 198 )   21-24   2012.11

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  • 弾性線維性仮性黄色腫における特徴的なダーモスコピー所見

    守内 玲寧, 西江 渉, 新熊 悟, 藤田 靖幸, 清水 宏

    日本皮膚科学会雑誌   122 ( 10 )   2507 - 2507   2012.9

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  • 慢性骨髄性白血病を合併したWells症候群の1例

    中里 信一, 藤田 靖幸, 濱出 洋平, 長谷部 育恵, 西江 渉, 清水 宏, 杉田 純一

    日本皮膚科学会雑誌   122 ( 3 )   635 - 636   2012.3

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  • 皮膚結節性アミロイドーシスの2例

    泉 健太郎, 猪熊 大輔, 笠井 麻希, 藤田 靖幸, 氏家 英之, 山中 快子, 伊藤 圭, 清水 宏

    日本皮膚科学会雑誌   122 ( 1 )   51 - 51   2012.1

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  • 若年女性に発症した好酸球性膿疱性毛包炎の1例

    中里信一, 藤田靖幸, 濱出洋平, 平田悠, 長谷部育恵, 浜坂明日香, 西江渉, 清水宏

    日本皮膚科学会雑誌   122 ( 12 )   2012

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  • 重症薬疹におけるグラニュライシン迅速測定キット有用性の検討

    齋藤 奈央, 阿部 理一郎, 藤田 靖幸, 吉岡 直也, 喬 洪江, 保科 大地, 前 博克, 林 宏明, 藤本 亘, 梶原 一亨, 尹 浩信, 小豆澤 宏明, 片山 一朗, 清水 宏

    Journal of Environmental Dermatology and Cutaneous Allergology   5 ( 3 )   272 - 272   2011.7

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  • Production of SJS/TEN model mice using patients PBMCs and skin

    N. Saito, R. Abe, N. Yoshioka, H. Qiao, Y. Fujita, D. Hoshina, H. Shimizu

    JOURNAL OF INVESTIGATIVE DERMATOLOGY   131   S94 - S94   2011.4

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  • 下腿の浮腫と硬化を伴う紅斑

    飯谷麻里, 小玉和郎, 泉健太郎, 藤田靖幸, 阿部由紀子, 阿部理一郎, 清水宏

    日本皮膚病理組織学会会誌   2011.3

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  • トラニラストの内服が有効であったeruptive syringomaの2例

    堀江 啓太, 新熊 悟, 藤田 靖幸, 氏家 英之, 剱持 靖子, 青柳 哲, 清水 宏

    日本皮膚科学会雑誌   121 ( 3 )   605 - 605   2011.3

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  • Regenerative medicine for severe congenital skin disorders: restoration of deficient skin component proteins by stem cell therapy Invited Reviewed

    Fujita Yasuyuki, Abe Riichiro, Nishie Wataru, Shimizu Hiroshi

    Inflammation and Regeneration   31 ( 3 )   282 - 289   2011

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    Some congenital skin disorders lacking structure proteins in the basement membrane zone carry severe prognosis because of severe erosion and skin dysfunction on the whole body. So far, several therapeutic strategies have been emerging for such disorders: 1. gene therapies, 2. protein therapies and 3. cell therapies. Cell therapies have a potential to affect skin systemically, and stem cell transplantation is one of the most hopeful candidates for treating severe congenital skin disorders such as epidermolysis bullosa, from a perspective of transdifferentiation and re-programming of stem cells. We review here the recent strategies and progress of stem cell transplantation for epidermolysis bullosa.

    DOI： 10.2492/inflammregen.31.282

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    Other Link： http://search.jamas.or.jp/link/ui/2012198361

  • 表皮水疱症に対する新規治療法の開発

    藤田靖幸

    かなえ医薬振興財団研究業績集(Web)   40th   2011

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  • グラニュライシン迅速測定キットを用いた重症薬疹早期診断の検討

    阿部理一郎, 齋藤奈央, 藤田靖幸, 吉岡直也, 保科大地, 前博克, 林宏明, 藤本亘, 梶原一亨, 尹浩信, 小豆澤宏明, 片山一朗, 清水宏

    アレルギー   60 ( 9/10 )   2011

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  • Stevens-Johnson syndrome/Toxic epidermal necrolysisにおけるグラニュライシン迅速測定キット有用性の検討

    阿部理一郎, 齋藤奈央, 藤田靖幸, 吉岡直也, 保科大地, 清水宏, 前博克

    北海道医学雑誌   86 ( 6 )   2011

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  • Analysis of the frequency of regulatory T cells in recovered SJS/TEN patients

    Naoya Yoshioka, Riichiro Abe, Junko Murata, Nao Saito, Yasuyuki Fujita, Daichi Hoshina, Hiroshi Shimizu

    JOURNAL OF INVESTIGATIVE DERMATOLOGY   130   S41 - S41   2010.9

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  • Investigation of VEGF signaling on human angiosarcoma using a novel experimental mode

    Daichi Hoshina, Riichiro Abe, Naoya Yoshioka, Hiroo Hata, Yasuyuki Fujita, Satoru Aoyagi, Hiroshi Shimizu

    JOURNAL OF INVESTIGATIVE DERMATOLOGY   130   S53 - S53   2010.9

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  • Remarkable tumor disruption induced by anti-angiogenic receptor tyrosine kinase inhibitor in a novel experimental model of human angiosarcoma

    D. Hoshina, R. Abe, H. Hata, Y. Fujita, S. Aoyagi, H. Shimizu

    JOURNAL OF INVESTIGATIVE DERMATOLOGY   130   S24 - S24   2010.4

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  • 亜鉛による歯科金属アレルギーの1例

    齋藤奈央, 山根尚子, 松村若菜, 藤田靖幸, 猪熊大輔, 黒嶋伸一郎, 浜坂幸吉, 清水宏

    J Environ Dermatol Cutan Allergol   3 ( 4 )   324   2009.10

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  • 皮膚結節性アミロイドーシスの2例

    泉 健太郎, 猪熊 大輔, 笠井 麻希, 藤田 靖幸, 氏家 英之, 山中 快子, 伊藤 圭, 清水 宏

    日本皮膚科学会雑誌   119 ( 4 )   752 - 752   2009.3

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  • 血清granulysin値は重症薬疹の発症早期に上昇する

    吉岡直也, 阿部理一郎, 村田純子, 藤田靖幸, 清水宏

    アレルギー   58 ( 3/4 )   2009

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  • Pigment Epithelium-Derived Factor Prevents Melanoma Growth via Angiogenesis Inhibition Reviewed

    Riichiro Abe, Yasuyuki Fujita, Sho-ichi Yamagishi, Hiroshi Shimizu

    CURRENT PHARMACEUTICAL DESIGN   14 ( 36 )   3802 - 3809   2008.12

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    DOI： 10.2174/138161208786898626

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  • ハイドロキシウレアにより生じた下腿潰瘍の1例

    伊藤幹, 阿部理一郎, 藤田靖幸, 有田賢, 清水忠道, 清水宏, 橋野聡

    日本皮膚科学会雑誌   118 ( 7 )   1273   2008.6

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  • COL17 is a key player of epithelial-mesenchymal interaction in tooth formation

    T. Asaka, M. Akiyama, T. Domonn, W. Nishie, Y. Fujita, S. Tanimura, Y. Kitagawa, H. Shimizu

    JOURNAL OF INVESTIGATIVE DERMATOLOGY   128   S97 - S97   2008.4

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  • Topical application of anti-angiogenic peptides based on pigment epithelium-derived factor can improve psoriasis

    R. Abe, S. Yamagishi, Y. Fujita, M. Sasaki, T. Matsui, K. Nakamura, T. Imaizumi, T. Shimizu, R. Bucala, H. Shimizu

    JOURNAL OF INVESTIGATIVE DERMATOLOGY   128   S2 - S2   2008.4

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  • Analyses of enamel formation in type 17 collagen knockout mice

    Takuya Asaika, Masashi Akiyama, Nishie Wataru, Fujita Yasuyuki, Tanimura Shintarou, Yoshimasa Kitagawa, Hiroshi Shimizu

    JOURNAL OF DERMATOLOGY   35 ( 3 )   195 - 195   2008.3

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  • 骨髄浸潤をきたしたMerkel細胞癌の1例

    根本 育恵, 松村 和子, 藤田 靖幸, 近藤 真, 大西 勝憲, 夏賀 健, 氏家 英之, 冨田 幸希, 加藤 直子

    日本皮膚科学会雑誌   117 ( 1 )   69 - 69   2007.1

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  • Scleroderma様変化を伴ったInterstitial Granulomatous Drug Reaction

    小玉和郎, 根本育恵, 藤田靖幸, 阿部由紀子, 清水忠道, 清水宏

    日本皮膚病理組織学会会誌   22 ( 2 )   2007

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  • ハイドロキシウレアによる下腿潰ようの1例

    伊藤幹, 阿部理一郎, 藤田靖幸, 有田賢, 清水忠道, 橋野聡, 清水宏

    日本皮膚科学会雑誌   116 ( 4 )   474   2006.4

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  • Osler-Rendu-Weber病の1例

    佐藤那奈, 藤田靖幸, 松村和子

    日本皮膚科学会雑誌   116 ( 4 )   2006

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  • 経過が遷延したHenoch-Schoenlein purpuraの1例

    佐藤那奈, 藤田靖幸, 松村和子, 鈴木岳, 安田卓二

    日本皮膚科学会雑誌   116 ( 4 )   2006

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  • 体幹・四肢の壊死を伴う硬結

    小玉和郎, 根本育恵, 藤田靖幸, 阿部由紀子, 清水忠道, 清水宏

    日本皮膚病理組織学会会誌   21 ( 2 )   2006

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  • Cutaneous sarcoidosis with pathological presentation as a tumor like muscular granuloma

    Nemoto, I, T Shimizu, Y Fujita, Y Tsuji-Abe, H Shimizu

    JOURNAL OF INVESTIGATIVE DERMATOLOGY   125 ( 6 )   A27 - A27   2005.12

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  • RIST施行後寛解を維持しているCutaneous T-cell lymphoma(CTCL)の一例

    加畑馨, 高畑むつみ, 川村孝仁, 藤沢文絵, 近藤健, 小林寿美子, 橋野聡, 浅香正博, 今村雅寛, 藤田靖幸, 清水宏

    臨床血液   46 ( 8 )   2005

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  • folliculosebaceous cystic hamartoma(FSCH)の2例

    谷村心太郎, 有田賢, 巌文哉, 増子麻希, 藤田靖幸, 川崎浩之, 阿部理一郎, 沢村大輔, 木村鉄宣

    日本皮膚科学会雑誌   115 ( 3 )   2005

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  • 仏壇のロウソクによる熱傷の4例

    木村中, 舟山恵美, 蔵盛理保子, 藤田靖幸

    熱傷   2004.6

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  • 紅斑のみられる皮膚疾患カラーアトラス 6.ときに紅斑 水疱性類天疱瘡 Invited Reviewed

    藤田靖幸, 秋山真志, 清水宏

    皮膚病診療   26   2004

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Presentations

  • Glister in Blister -from autoimmune to inherence- Invited International conference

    Yasuyuki Fujita

    Mae Fah Luang University Clinical Conference  2026.3 

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  • 表皮水疱症に寄り添って Invited

    藤田靖幸

    第314回日本皮膚科学会東海地方会  2025.12 

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    Event date： 2025.12

    Presentation type：Oral presentation (invited, special)  

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  • ある皮膚科医ができるまで-塞翁が馬を乗りこなそう-． Invited

    藤田靖幸

    北嶺中高等学校 Medical School  2025.12 

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    Event date： 2025.12

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  • あたらしい皮膚科の治療-真菌症から先天性疾患まで-. Invited

    藤田靖幸

    日本臨床皮膚科医会青森支部講演会  2025.11 

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    Event date： 2025.11

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  • 臨床を超えた皮膚科を楽しもう：乾癬から表皮水疱症まで Invited

    藤田靖幸

    名古屋大学皮膚科フロンティアセミナー  2025.11 

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    Event date： 2025.11

    Presentation type：Oral presentation (keynote)  

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  • 皮膚病理の超基本：顕微鏡の使い方とはじめての水疱症 Invited

    藤田靖幸

    第89回日本皮膚科学会東京支部学術大会  2025.11 

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  • 乾癬のお話～医学の進歩とともに～ Invited

    藤田靖幸

    乾癬学習懇談会2025 in旭川  2025.11 

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    Event date： 2025.11

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  • リハビリテーション診療において遭遇しやすい皮膚疾患とその対応． Invited

    藤田靖幸

    第9回日本リハビリテーション医学会秋季学術集会  2025.10 

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    Event date： 2025.10

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  • 果てしなきシン乾癬の道 Invited

    藤田靖幸

    第40回日本乾癬学会学術大会  2025.9 

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    Event date： 2025.9

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  • 進化する乾癬治療とバイオシミラーの展望． Invited

    藤田靖幸

    医療薬学フォーラム2025 第33回クリニカルファーマシンポジウム  2025.6 

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    Event date： 2025.6

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  • 塞翁が馬～ある皮膚科医の場合～ Invited

    藤田靖幸

    第442回日本皮膚科学会北海道地方会  2025.6 

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    Presentation type：Oral presentation (invited, special)  

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  • あたらしい表皮水疱症の治療＋α Invited

    藤田靖幸

    第295回日本皮膚科学会岡山地方会  2025.5 

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    Event date： 2025.5

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  • 先天性表皮水疱症の最近の進歩 進化しつつある表皮水疱症の治療 Invited

    藤田 靖幸

    第41回日本臨床皮膚科医会総会・学術大会  2025.4  日本臨床皮膚科医会

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    Event date： 2025.4

    Language：Japanese   Presentation type：Oral presentation (invited, special)  

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  • 皮膚科万事塞翁が馬～表皮水疱症から乾癬治療まで～ Invited

    藤田靖幸

    第405回沖縄皮膚科勉強会  2024.8 

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    Event date： 2024.8

    Presentation type：Oral presentation (keynote)  

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  • Glister in Blister -from autoimmune to inherence- Invited International conference

    Yasuyuki Fujita

    The 22nd annual meeting of Korean Society for Dermatopathology  2024.5 

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    Event date： 2024.5

    Presentation type：Oral presentation (invited, special)  

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  • Differences In Clinical Symptoms Between GPP And PsV From A Pathogenetic Perspective Invited

    藤田靖幸

    2024.8 

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    Event date： 2024

    Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

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  • 皮膚の難病に挑む：表皮水疱症とMuse細胞の可能性 Invited

    藤田靖幸

    Tree OF Muse Cell 講演会  2023.9 

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    Event date： 2023.9

    Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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  • 脱「初心者」！ 水疱症診断 Invited

    藤田靖幸

    皮膚病理あどばんすと2023  2023.4 

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    Event date： 2023.4

    Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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  • 表皮水疱症に寄り添う~診断・ケアそして治療へ~ Invited

    藤田靖幸

    第47回日本小児皮膚科学会学術大会  2023.7 

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    Event date： 2023

    Presentation type：Oral presentation (invited, special)  

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  • 胼胝様の外観をきたしたeccrine angiomatous hamartomaの1例

    藤田靖幸, 山賀三紗子, 葭本倫大, 山口貴子, 辻隆裕, 梅津修, 清水聡子

    第75回日本皮膚科学会西部支部学術大会  2023.9 

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    Event date： 2023

    Language：Japanese   Presentation type：Oral presentation (general)  

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  • どうぶつと皮膚疾患 Invited

    藤田靖幸

    第39回日本臨床皮膚科医会総会・学術大会  2023.6 

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    Event date： 2023

    Language：Japanese   Presentation type：Oral presentation (invited, special)  

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  • 好酸球性環状紅斑~EAC?EAE?Wells?~ Invited

    藤田靖幸

    日本皮膚免疫アレルギー学会総会学術大会プログラム・抄録集  2023 

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    Event date： 2023

    Presentation type：Symposium, workshop panel (nominated)  

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  • 化学療法室で遭遇しやすい皮膚症状と対応 Invited

    藤田靖幸

    市立札幌病院第2回化学療法センター研修会  2022.11 

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    Event date： 2022.11

    Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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  • A case of oral lichen planus and oral candidiasis in a psoriatic patient treated with secukinumab.

    藤田靖幸, 須貝達朗, 真屋由佳, 稲村衣美, 平野瑶子, 清水聡子

    2022.9 

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    Event date： 2022

    Presentation type：Oral presentation (general)  

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  • 先天性表皮水疱症の診断と治療 Invited

    藤田靖幸

    第121回日本皮膚科学会総会  2022.6 

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    Event date： 2022

    Presentation type：Symposium, workshop panel (nominated)  

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  • 診断に難渋した症例4選(+α?) Invited

    藤田靖幸

    第121回日本皮膚科学会総会  2022.6 

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    Event date： 2022

    Presentation type：Symposium, workshop panel (nominated)  

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  • 教育実習セミナー（皮膚病理）：水疱・膿疱症 Invited

    藤田靖幸

    第120回日本皮膚科学会総会  2021.6 

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    Event date： 2021

    Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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  • Recurrence of psoriasis vulgaris after the treatment with pembrolizumab

    藤田靖幸, 真屋由佳, 稲村衣美, 須貝達朗, 三浪圭太, 清水聡子

    日本乾癬学会学術大会プログラム・抄録集  2021 

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    Event date： 2021

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  • 成人栄養障害型表皮水疱症患者を対象としたMuse細胞製品CL2020の国内1/2相試験:52週までの安全性の検討

    藤田靖幸, 藤田靖幸, 野原拓馬, 高島翔太, 夏賀健, 中村秀樹, 清水宏, 足立太起, 吉田憲司, 石河晃, 新熊悟, 武市拓也, 秋山真志, 和田理

    第72回日本皮膚科学会中部支部学術大会  2021.11 

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    Event date： 2021

    Presentation type：Oral presentation (general)  

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  • Exacerbation of cutaneous warts in a psoriatic patient treated with risankizumab

    藤田靖幸, 真屋由佳, 水上卓哉, 宮本航大, 松村和子, 清水聡子

    日本乾癬学会学術大会プログラム・抄録集  2020 

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    Event date： 2020

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  • ビタミンB12製剤が皮疹の増悪因子であった全身型金属アレルギーの1例

    藤田靖幸, 水上卓哉, 真屋由佳, 守内玲寧, 清水聡子, 岩崎沙理, 深澤雄一郎, 芝木晃彦

    日本皮膚科学会雑誌  2020 

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    Event date： 2020

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  • 表皮水疱症に対する自家培養表皮の可能性 Invited

    藤田靖幸, 藤田靖幸

    日本皮膚科学会雑誌  2019 

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    Event date： 2019

    Presentation type：Symposium, workshop panel (nominated)  

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  • 表皮幹細胞の基礎と臨床 Invited

    藤田靖幸

    日本皮膚科学会雑誌  2018 

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    Event date： 2018

    Presentation type：Symposium, workshop panel (nominated)  

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  • CL2020, a human multilineage-differentiating stress enduring cells-rich product, has a potential to treat dystrophic epidermolysis bullosa

    Y. Fujita, S. Shinkuma, S. Lee, C. Nakayama, W. Matsumura, T. Nomura, M. Kawamura, N. Masutomi, H. Shimizu

    JOURNAL OF INVESTIGATIVE DERMATOLOGY  2017.10  ELSEVIER SCIENCE INC

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    Event date： 2017.10

    Language：English  

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  • 真皮全層で増生する毛細血管

    藤田 靖幸, 新熊 悟, 清水 宏

    日本皮膚悪性腫瘍学会学術大会プログラム・抄録集  2017.5  (一社)日本皮膚悪性腫瘍学会

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    Event date： 2017.5

    Language：Japanese  

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  • 病理像と臨床からみえてくる乾癬 Invited

    藤田靖幸

    西日本皮膚科  2017 

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    Event date： 2017

    Presentation type：Symposium, workshop panel (nominated)  

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  • 表皮水疱症と歩む:最近のトピックス

    藤田靖幸

    日本皮膚科学会雑誌  2017 

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    Event date： 2017

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  • Clinical management and experimental findings in epidermolysis bullosa

    Y. Fujita, H. Shimizu

    AUSTRALASIAN JOURNAL OF DERMATOLOGY  2016.11  WILEY-BLACKWELL

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    Event date： 2016.11

    Language：English  

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  • A CASE OF RECESSIVE DYSTROPHIC EPIDERMOLYSIS BULLOSA WITH LONG-TERM FOLLOW-UP OF CULTURED EPIDERMAL AUTOGRAFT

    Y. Fujita, S. Shinkuma, D. Sawamura, H. Kawasaki, H. Nakamura, M. Inoie, W. Nishie, H. Shimizu

    WOUND REPAIR AND REGENERATION  2014.1 

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    Event date： 2014.1

    Language：English  

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  • 著明な表皮向性を伴ったdiffuse large B-cell lymphomaの1例

    藤田靖幸, 安川香菜, 野本晶子, 熊野弘毅, 清水宏

    日本皮膚科学会雑誌  2014 

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    Event date： 2014

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  • 左上胸部に生じた結節

    藤田靖幸, 藤田靖幸, 安川香菜, 野本晶子, 熊野弘毅, 清水宏

    日本皮膚病理組織学会抄録集  2014 

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    Event date： 2014

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  • 自家培養表皮移植を行い長期観察した劣性栄養障害型表皮水疱症の1例

    藤田 靖幸, 新熊 悟, 澤村 大輔, 川崎 浩之, 中村 裕之, 井家 益和, 西江 渉, 清水 宏

    日本皮膚科学会雑誌  2013.4  (公社)日本皮膚科学会

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    Event date： 2013.4

    Language：Japanese  

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  • 表皮水疱症の病態と治療

    藤田靖幸

    日本皮膚科学会雑誌  2013 

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    Event date： 2013

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  • 左前腕の紅色結節

    藤田靖幸, 青柳哲, 辻脇真澄, 本間英里奈, 氏家英之, 藤田裕美, 畑中佳奈子, 清水宏

    日本皮膚病理組織学会抄録集  2013 

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    Event date： 2013

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  • 重症型表皮水疱症に対する新規幹細胞療法の検討

    藤田靖幸

    日本皮膚科学会雑誌  2013 

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    Event date： 2013

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  • 自家培養表皮移植を行い長期観察した劣性栄養障害型表皮水疱症の1例

    藤田 靖幸, 新熊 悟, 澤村 大輔, 川崎 浩之, 中村 裕之, 井家 益和, 西江 渉, 清水 宏

    日本創傷治癒学会プログラム・抄録集  2012.12  (一社)日本創傷治癒学会

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    Event date： 2012.12

    Language：Japanese  

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  • 骨髄移植は表皮水疱症モデルマウスに対する治療法となる

    藤田靖幸, 阿部理一郎, 猪熊大輔, 佐々木美香子, 守屋歩, 西江渉, 清永宏

    日本皮膚科学会雑誌  2012 

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    Event date： 2012

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  • Both hematopoietic and mesenchymal stem cells contribute to the production of basement membrane protein in bone marrow transplantation treatment model mouse

    Y. Fujita, D. Inokuma, W. Nishie, H. Nakamura, M. Akiyama, D. Sawamura, H. Shimizu

    JOURNAL OF INVESTIGATIVE DERMATOLOGY  2009.9 

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    Event date： 2009.9

    Language：English  

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  • Bone marrow transplantation restores deficient epidermal basement membrane protein and improves the clinical phenotype in epidermolysis bullosa model mice

    Y. Fujita, R. Abe, D. Inokuma, M. Sasaki, D. Hoshina, W. Nishie, J. R. McMillan, H. Nakamura, T. Shimizu, D. Sawamura, H. Shimizu

    JOURNAL OF INVESTIGATIVE DERMATOLOGY  2008.4 

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    Event date： 2008.4

    Language：English  

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  • 色素沈着を主訴とした特発性Addison病の1例

    藤田靖幸, 松村和子, 佐藤那奈, 村田純子, 吉田昌弘, 和田典男

    日本皮膚科学会雑誌  2008 

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    Event date： 2008

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  • 骨髄移植は17型コラーゲンノックアウトマウスにおいて欠損蛋白を補充し生命予後を改善する

    藤田靖幸, 阿部理一郎, 猪熊大輔, 佐々木美香子, 西江渉, MCMILLAN James, 中村秀樹, 清水忠道, 澤村大輔, 清水宏

    日本結合組織学会学術大会抄録集  2008 

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    Event date： 2008

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  • 爪病変で初発し, 水疱を形成した多発性骨髄腫に伴うアミロイドーシス

    藤田靖幸

    日皮会誌  2006 

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    Event date： 2006

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  • 爪病変で初発し,水疱を形成した多発性骨髄腫に伴うアミロイドーシス

    藤田靖幸, 阿部由紀子, 清水宏, 松村和子

    日本皮膚科学会雑誌  2006 

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    Event date： 2006

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  • シメチジン内服後に症状が改善した晩発性皮膚ポルフィリン症の1例

    藤田靖幸, 松村和子

    日本皮膚科学会雑誌  2006 

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    Event date： 2006

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  • 色素沈着を主訴とした特発性Addison病の1例

    藤田靖幸, 松村和子, 佐藤那奈, 村田純子, 吉田昌弘, 和田典男

    日本皮膚科学会雑誌  2006 

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    Event date： 2006

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  • シメチジン内服後に症状が改善した晩発性皮膚ポルフィリン症

    藤田靖幸, 松村和子

    日本皮膚科学会雑誌  2006 

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    Event date： 2006

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  • aggressive angiomyxomaの1例

    藤田靖幸, 松村和子, 高橋秀史

    日本皮膚科学会雑誌  2006 

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    Event date： 2006

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  • 環状紅斑から診断に至った小児Sjoegren症候群の1例

    藤田靖幸, 松村和子, 村田純子, 黒田努, 宇加江進

    日本皮膚科学会雑誌  2006 

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  • Nail dystrophy and blister formation in myeloma assciated amyloidosis - Immunopathological features

    Y Fujita, Y Tsuji-Abe, KC Sato-Matsumura, M Akiyama, H Shimizu

    JOURNAL OF INVESTIGATIVE DERMATOLOGY  2005.12 

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    Event date： 2005.12

    Language：English  

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  • 多毛と色素沈着とを伴った先天性皮膚欠損症の1例

    藤田靖幸, 横田浩一, 木村中, 清水宏

    日本皮膚科学会雑誌  2004 

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    Event date： 2004

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  • センノシドによるInterstitial granulomatous drug reactionの1例

    藤田靖幸, 清水忠道, 清水宏

    日本皮膚科学会雑誌  2004 

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    Event date： 2004

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  • 口腔へん平苔せんに対するタクロリムス外用療法中に生じたsulfur granule形成を伴う病変

    藤田靖幸, 横田浩一, 清水宏

    日本皮膚科学会雑誌  2003 

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    Event date： 2003

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  • 皮膚科学の最近の進歩-分子標的薬から遺伝子治療まで- Invited

    藤田靖幸

    第24回森山グループ研修学会  2026.2 

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Awards

  • 第9回テルモ財団賞

    2021.3   公益財団法人テルモ生命科学振興財団   先天性皮膚疾患に対する根本的治療の開発

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  • 第420回日本皮膚科学会北海道地方会ベストスライド賞

    2020.9   日本皮膚科学会北海道地方会  

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  • 第27回中冨健康科学振興財団 研究助成金

    2015.1   中冨健康科学振興財団  

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  • テルモ科学技術振興財団一般研究開発助成II

    2014.12   テルモ科学技術振興財団  

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  • 平成25年度フラテ研究奨励賞

    2014.1   北海道大学医学部同窓会  

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  • 平成25年度研究助成金

    2013.3   財団法人日本リディアオリリー協会  

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  • 第23回コスメトロジー研究振興財団助成金

    2012.10   コスメトロジー研究振興財団  

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  • 平成24年度公益財団法人秋山記念生命科学振興財団研究助成（奨励助成）

    2012.6   公益財団法人秋山記念生命科学振興財団  

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  • 2012年度医学系研究奨励（臨床）

    2012.6   公益財団法人武田科学振興財団  

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  • 第15回花王芸術・科学財団科学技術研究助成

    2012.3   花王芸術・科学財団  

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  • 平成24年度日本皮膚科学会基礎医学研究費

    2012.3   日本皮膚科学会  

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  • 平成23年度上原記念生命科学財団研究奨励金

    2011.12   上原記念生命科学財団  

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  • 日本皮膚科学会第387回北海道地方会ベストスライド賞

    2011.12   日本皮膚科学会北海道地方会  

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  • 第40回かなえ医薬振興財団研究助成金

    2011.11   かなえ医薬振興財団  

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  • 平成22年度北海道大学医学研究科・医学部優秀論文賞

    2011.3   北海道大学医学部同窓会  

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  • 平成23年度日本皮膚科学会皆見省吾記念賞

    2011   日本皮膚科学会   Bone marrow transplantation restores epidermal basement membrane protein expression and rescues epidermolysis bullosa model mice

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  • 第29回高桑栄松奨学基金奨励賞

    2010.2   北海道大学医学部  

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  • 第55回マトリックス研究会大会合同学術集会 Young Investigator Award

    2008.5   マトリックス研究会  

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  • 第2回北海道大学大学院医学研究科・医学部医学科音羽博次奨学基金

    2006.9   北海道大学医学部  

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Research Projects

  • Establishment of epidermolysis bullosa model mouse with revertant mosaicism and its treatment

    Grant number：17H01572  2017.4 - 2020.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)  Grant-in-Aid for Scientific Research (A)

    Shimizu Hiroshi

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    Grant amount：\43,030,000 （ Direct Cost: \33,100,000 、 Indirect Cost：\9,930,000 ）

    Almost all patients with epidermolysis bullosa lacking type XVII collagen are known to have revertant mosaic spots. This revertant mosaicism is a phenomenon in which gene abnormalities are naturally repaired without any artificial modification of the gene, but the mechanism is not clear. In this study, we developed a mouse model of epidermolysis bullosa that could develop revertant mosaicism. Using this mouse, we have succeeded in inducing revertant mosaic cells, and we are now analyzing these cells.

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  • Comprehensive study for pathogenesis of severe drug eruption

    Grant number：15H04884  2015.4 - 2018.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)  Grant-in-Aid for Scientific Research (B)

    Abe Riichiro

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    Grant amount：\17,940,000 （ Direct Cost: \13,800,000 、 Indirect Cost：\4,140,000 ）

    1) Mechanism of epidermal cell death in severe drug eruption: We clarified the detailed mechanism of cell death by Annexin A1 / FPR1. MLKL phosphorylation was confirmed in addition to the normal necroptosis pathway RIP1 / RIP3 complex formation.
    2) Search for cell death inhibitors targeting Annexin A1 / FPR1: We searched for FPR1 antagonists to be inhibitors of necroptosis. Several candidate substances could be identified. In addition, several drug candidates were identified as existing drugs (drug repositioning).
    3) Search for new biomarkers in severe drug eruption: By comparing proteins and gene expression by mass spectrometry and RNA-seq using patient samples, not only at the time of onset but also the onset prediction factor was searched. Several rising candidate markers specific for severe drug eruption were identified.

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  • Treatment of epidermolysis bullosa with revertant keratinocyte-derived iPS cells

    Grant number：15K09753  2015.4 - 2018.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    Fujita Yasuyuki, MATSUMURA WAKANA, NAKAYAMA CHIHIRO

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    Grant amount：\4,810,000 （ Direct Cost: \3,700,000 、 Indirect Cost：\1,110,000 ）

    Cell-based therapies such as allogeneic mesenchymal stem/stromal cells (MSCs) transplantation for recessive dystrophic epidermolysis bullosa (RDEB) were explored. However, some hurdles exist to come over in current MSC-based therapies; limited proliferation and limited cell survival. To solve these problems, we focused on keratinocyte-derived induced pluripotent stem cells (iPSCs). Keratinocytes from intact areas of patients might have revertant mosaicism where the pathogenic mutations are spontaneously corrected. In this study, we succeeded to develop MSCs from keratinocytes-derived iPSCs (KC-iPSC-MSCs) of normal human and a RDEB patient. Keratinocytes-derived iPSCs (KC-iPSCs) were cultured with activin A, BIO and BMP4 to induct mesoderm lineage, and then cultured with bFGF and EGF. In 14 days, spindle-shaped cells
    appeared which showed mesenchymal differentiation. Furthermore, the intravenous injection of the KC-iPSC-MSCs into wounded mice induced human type VII collagen.

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  • 復帰変異モザイク（Revertant mosaicism）を応用した先天性難治性皮膚疾患に対する自家培養表皮シート療法

    2014.12 - 2018.3

    医薬基盤・健康・栄養研究所  希少疾病用再生医療品等開発支援事業 

    清水 宏, 西江 渉, 藤田靖幸, 新熊 悟, 井家益和, 佐藤典宏

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    Authorship：Coinvestigator(s) 

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  • Investigation of induced stem cells treatment for epidermolysis bullosa

    Grant number：25713041  2013.4 - 2015.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (A)  Grant-in-Aid for Young Scientists (A)

    FUJITA Yasuyuki

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    Grant amount：\26,130,000 （ Direct Cost: \20,100,000 、 Indirect Cost：\6,030,000 ）

    Epidermolysis bullosa (EB) is a group of genodermatoses that cause blister formations from the congenital abnormality of anchor proteins between the epidermis and the dermis. There have been several strategies for the treatment of EB, and so far, cell therapies are the most promising approach because of the potential of systemic effects. We have proved that stem cell therapies, including bone marrow transplantation, hematopoietic stem cell transplantation, can ameliorate the phenotype and survival prognosis in the junctional EB model mice that lack type XVII collagen (Col17). In this study we explore the possibility of induced pluripotent stem cells (iPSCs) for the treatment of EB, via induction of hematopoietic cell lineages. We preformed iPSCs-derived hematopoietic stem cell transplantation to Col17 knockout / Col17 humanized mice, and some of them showed slight expression of the lacked murine Col17 in the re-epithelized skin injuries.

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  • Contribution of mitochondrioa to keratinization

    Grant number：25670495  2013.4 - 2014.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research  Grant-in-Aid for Challenging Exploratory Research

    ABE Riichiro, FUJITA Yasuyuki, SUTO Asuka

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    Grant amount：\3,770,000 （ Direct Cost: \2,900,000 、 Indirect Cost：\870,000 ）

    Mitochondria play critical roles in many cellular processes, including cell death. Recently, it is reported that mitochondrial fission/fusion processes are important for cell death. Mitochondrial morphologies are regulated by several GTPases: fusion is mediated by mitofusin 1 (Mfn1) and Mfn2. Proper mitochondrial dynamics are critical for human health.
    Keratinization requires strict regulation of keratinocyte proliferation and cell death. However, the role of mitochondria in keratinization remains obscure. We showed that mitochondria in keratinocyte cells were distributed in the perinuclear regions. No difference in mitochondrial morphology between the basal and the suprabasal cells. However, the number of mitochondria per cell was significantly higher in the suprabasal cells than in the basal cells. We found that the expression patterns of Mfn1 and Mfn2 were quite different: Mfn1 was expressed in the suprabasal cells, whereas Mfn2 was expressed only in the basal cells.

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  • Investigation of hematopoietic stem cell transplantation for epidermolysis bullosa

    Grant number：24249062  2012.4 - 2015.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)  Grant-in-Aid for Scientific Research (A)

    SHIMIZU Hiroshi, ABE Riichiro, NISHIE Wataru, FUJITA Yasuyuki, AKIYAMA Masashi, KOJIMA Seiji, NAKAMURA Hideki

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    Grant amount：\45,630,000 （ Direct Cost: \35,100,000 、 Indirect Cost：\10,530,000 ）

    Epidermolysis bullosa (EB) is a group of genodermatoses that cause blister formations from the congenital abnormality of anchor proteins between the epidermis and the dermis. There have been several strategies for the treatment of EB, and so far, cell therapies are the most promising approach because of the potential of systemic effects. We have proved that stem cell therapies, including bone marrow transplantation, hematopoietic stem cell transplantation, can ameliorate the phenotype and survival prognosis in the junctional EB model mice that lack type XVII collagen (Col17). In this study we explore more efficient approaches of stem cell therapies for EB, including intramedullary transplantation, mesenchymal stromal/stem cell infusion, and investigate factors in association with transdifferentiation from bone marrow-derived stem cells into keratinocytes.

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  • Investigation for pathogenesis of cutaneous severe adverse drug reaction.

    Grant number：24390275  2012.4 - 2015.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)  Grant-in-Aid for Scientific Research (B)

    ABE Riichiro, FUJITA Yasuyuki

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    Grant amount：\18,200,000 （ Direct Cost: \14,000,000 、 Indirect Cost：\4,200,000 ）

    Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening, cutaneous adverse drug reactions that are accompanied by keratinocyte cell death. Dead keratinocytes from SJS/TEN lesions exhibited necrosis, bymorphological criteria. We identified annexin A1 as a key mediator of keratinocyte death via formyl peptide receptor 1 (FPR1). Our results demonstrate that a necroptosis pathway, likely mediated by annexin 1 acting through the FPR1 receptor, contributes to SJS/TEN.

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  • Development of cell therapy for epidermolysis bullosa

    Grant number：23689053  2011 - 2012

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (A)

    FUJITA Yasuyuki

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    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\25,740,000 （ Direct Cost: \19,800,000 、 Indirect Cost：\5,940,000 ）

    We performed stem cell transplantation including bone marrow transplantation and mesenchymal stem/stromal cell infusion into adult epidermolysis bullosa model mice (type XVII collagen (COL17) knockout mice). 1. Intramedullary infusion/transplantation induced better engraftment in the peripheral blood than conventional intravascular infusion, and the recovery of COL17 was also observed as well. 2. Donor-derived keratinocytes and recipient-derived keratinocytes were respectively collected by flowcytometer, and investigated mRNA expression differences by microarray technique. 57 genes were detected which have different mRNA expression between the two groups. 3. In corporation with Nagoya University, clinical trials of stem cell transplantation for severe epidermolysis bullosa patients are now applying, and it is under consideration.

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  • Development of stem cell therapy for epidermolysis bullosa model mice expressing humanized dermo-epidermal junctional protein

    Grant number：23659539  2011

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research  Grant-in-Aid for Challenging Exploratory Research

    SHIMIZU Hiroshi, ABE Riichiro, FUJITA Yasuyuki

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    Grant amount：\3,900,000 （ Direct Cost: \3,000,000 、 Indirect Cost：\900,000 ）

    The aim of the project is to investigate the effect of stem cell therapy for congenital severe skin disorder, recessive dystrophic epidermolysis bullosa(EB), using protein-humanized EB model mice. We performed bone marrow transplantation from GFP Tg mice to EB model mice lacking murine type VII collagen(COL7) and expressing incomplete/complete human COL7. Epithelized skin areas showed GFP+bone marrow-derived keratinocytes as many as 0. 2%. Murine COL7 mRNA and COL7 protein were also expressed in some mice, but the expression levels were low. We are now performing and analyzing another bone marrow transplantation model using HMGB1, CCL27 and CCL19, which are known to enhance transdifferentiation and recruitment from bone marrow cells to skin component cells.

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  • 骨髄由来細胞を用いた皮膚構成細胞分化の研究

    2006

    その他の研究制度 

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    Grant type：Competitive

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Teaching Experience

  • 症候別課題別講義

    2025 Institution：旭川医科大学医学部

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  • 感覚器病態学

    2025 Institution：旭川医科大学医学部

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  • 統合演習

    2025 Institution：旭川医科大学医学部

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  • 皮膚科学

    2014 Institution：北海道大学医学部

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  • 皮膚科学

    2011 - 2018 Institution：北海道大学歯学部

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Social Activities

  • HTB「イチモニ！」健康けっこう調べ隊

    Role(s)： Appearance

    北海道テレビ  イチモニ！  2025.2

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    Type：TV or radio program

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Academic Activities

  • 第39回日本臨床皮膚科医会総会・学術大会 会頭

    Role(s)： Planning, management, etc.

    2023.6

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    Type：Competition, symposium, etc. 

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  • 皮膚病理あどばんすと2025秋

    Role(s)： Planning, management, etc.

    2025.11

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    Type：Academic society, research group, etc. 

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  • 皮膚病理あどばんすと2025春

    Role(s)： Planning, management, etc.,　Supervision (editorial)

    2025.4

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  • Referee on British Journal of Dermatology International contribution

    Role(s)： Peer review

    2025.1 - 2025.12

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    Type：Peer review 

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  • Referee on Journal of Dermatology International contribution

    Role(s)： Peer review

    2025.1 - 2025.12

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    Type：Peer review 

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  • Referee on Journal of Dermatological Science International contribution

    Role(s)： Peer review

    2025.1 - 2025.12

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    Type：Peer review 

    2025年 査読1件

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  • Referee on JAAD Case Reports International contribution

    Role(s)： Peer review

    2025.1 - 2025.12

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    Type：Peer review 

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  • Referee on JEADV Clinical Practice International contribution

    Role(s)： Peer review

    2025.1 - 2025.12

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    Type：Peer review 

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  • Referee on European Journal of Dermatology International contribution

    Role(s)： Peer review

    2025.1 - 2025.12

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    Type：Peer review 

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  • Referee on International Journal of Dermatology International contribution

    Role(s)： Peer review

    2025.1 - 2025.12

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    Type：Peer review 

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  • Referee on Clinical and Experimental Dermatology International contribution

    Role(s)： Peer review

    2025.1 - 2025.12

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    Type：Peer review 

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